UTP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27941103
2proteasome assembly (GO:0043248)4.99660772
3ATP synthesis coupled proton transport (GO:0015986)4.66685325
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66685325
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.63537111
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.46712861
7chaperone-mediated protein transport (GO:0072321)4.44123435
8chromatin remodeling at centromere (GO:0031055)4.19354156
9cullin deneddylation (GO:0010388)4.08555171
10CENP-A containing nucleosome assembly (GO:0034080)4.08148470
11respiratory electron transport chain (GO:0022904)4.02495036
12DNA replication checkpoint (GO:0000076)4.00257697
13protein complex biogenesis (GO:0070271)3.96880760
14electron transport chain (GO:0022900)3.96213794
15mitochondrial respiratory chain complex assembly (GO:0033108)3.92170199
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.91900112
17NADH dehydrogenase complex assembly (GO:0010257)3.91900112
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91900112
19maturation of 5.8S rRNA (GO:0000460)3.87000294
20protein deneddylation (GO:0000338)3.84546069
21termination of RNA polymerase III transcription (GO:0006386)3.81845177
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.81845177
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78540203
24regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61625688
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59520847
26pseudouridine synthesis (GO:0001522)3.59142822
27DNA double-strand break processing (GO:0000729)3.58532560
28protein neddylation (GO:0045116)3.58270241
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57186362
30respiratory chain complex IV assembly (GO:0008535)3.56608113
31histone exchange (GO:0043486)3.52105420
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52096821
33regulation of mitochondrial translation (GO:0070129)3.50729411
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47188922
35negative regulation of ligase activity (GO:0051352)3.47188922
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47076808
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.45897015
38regulation of mitotic spindle checkpoint (GO:1903504)3.45897015
39protein targeting to mitochondrion (GO:0006626)3.43572904
40spliceosomal snRNP assembly (GO:0000387)3.42860922
41ribosome assembly (GO:0042255)3.39153485
42rRNA modification (GO:0000154)3.37790777
43water-soluble vitamin biosynthetic process (GO:0042364)3.37569379
44DNA damage response, detection of DNA damage (GO:0042769)3.30671137
45purine nucleobase biosynthetic process (GO:0009113)3.27230098
46oxidative phosphorylation (GO:0006119)3.26131880
47protein localization to mitochondrion (GO:0070585)3.25735934
48ribosomal large subunit biogenesis (GO:0042273)3.25626700
49DNA strand elongation involved in DNA replication (GO:0006271)3.22840913
50rRNA processing (GO:0006364)3.22315660
51cytochrome complex assembly (GO:0017004)3.21197599
52establishment of protein localization to mitochondrion (GO:0072655)3.19675940
53maturation of SSU-rRNA (GO:0030490)3.19419213
54IMP biosynthetic process (GO:0006188)3.19292253
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.18593534
56telomere maintenance via semi-conservative replication (GO:0032201)3.14586254
57protein K6-linked ubiquitination (GO:0085020)3.13361946
58rRNA metabolic process (GO:0016072)3.13360950
59regulation of cellular amino acid metabolic process (GO:0006521)3.12801790
60replication fork processing (GO:0031297)3.12595826
61DNA replication-independent nucleosome organization (GO:0034724)3.11950508
62DNA replication-independent nucleosome assembly (GO:0006336)3.11950508
63kinetochore organization (GO:0051383)3.11530496
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11443947
65nucleobase biosynthetic process (GO:0046112)3.11260158
66cellular component biogenesis (GO:0044085)3.10358518
67DNA strand elongation (GO:0022616)3.09962389
68DNA catabolic process, exonucleolytic (GO:0000738)3.09276827
69histone mRNA metabolic process (GO:0008334)3.08484627
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07747962
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07163055
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07163055
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07163055
74peptidyl-histidine modification (GO:0018202)3.07151587
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03798284
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03798284
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02628243
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02628243
79protein localization to kinetochore (GO:0034501)3.02321846
80positive regulation of ligase activity (GO:0051351)3.01804662
81mitotic metaphase plate congression (GO:0007080)3.01074118
82translation (GO:0006412)3.00977198
83establishment of integrated proviral latency (GO:0075713)3.00344321
84kinetochore assembly (GO:0051382)3.00176031
85regulation of nuclear cell cycle DNA replication (GO:0033262)2.98595726
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97465267
87signal transduction involved in DNA damage checkpoint (GO:0072422)2.97465267
88ribonucleoprotein complex biogenesis (GO:0022613)2.96530523
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.96202092
90tRNA processing (GO:0008033)2.95978601
91protein-cofactor linkage (GO:0018065)2.95947143
92DNA deamination (GO:0045006)2.94049044
93ribosome biogenesis (GO:0042254)2.93895535
94mitochondrial RNA metabolic process (GO:0000959)2.92295410
95rRNA methylation (GO:0031167)2.88981143
96regulation of ubiquitin-protein transferase activity (GO:0051438)2.88762903
97tRNA metabolic process (GO:0006399)2.87638191
98IMP metabolic process (GO:0046040)2.87293431
99intracellular protein transmembrane import (GO:0044743)2.84688402
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84423914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.32849594
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.60788970
3E2F7_22180533_ChIP-Seq_HELA_Human4.51135983
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.17180672
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56923631
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.47230607
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36498598
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.35812762
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.32819380
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17274574
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96126922
12ELK1_19687146_ChIP-ChIP_HELA_Human2.93022717
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89681694
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.72831948
15VDR_23849224_ChIP-Seq_CD4+_Human2.64161046
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49755080
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40077970
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39073079
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38934762
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35747170
21FOXP3_21729870_ChIP-Seq_TREG_Human2.33217737
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25949946
23DCP1A_22483619_ChIP-Seq_HELA_Human2.13409524
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09608590
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.08555259
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07549163
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03543562
28ZNF274_21170338_ChIP-Seq_K562_Hela2.03163481
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00095128
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96856174
31MYC_18940864_ChIP-ChIP_HL60_Human1.94618927
32GABP_19822575_ChIP-Seq_HepG2_Human1.91585886
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90189092
34TTF2_22483619_ChIP-Seq_HELA_Human1.89741955
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87422471
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85597243
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84874109
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80011886
39XRN2_22483619_ChIP-Seq_HELA_Human1.76623947
40VDR_22108803_ChIP-Seq_LS180_Human1.76190661
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.75812548
42EWS_26573619_Chip-Seq_HEK293_Human1.65176040
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.59864954
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57489877
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.55314611
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.54748694
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52537821
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52246499
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50215458
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49011647
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.45654628
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44375760
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40138376
54FUS_26573619_Chip-Seq_HEK293_Human1.36886002
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36761063
56AR_21909140_ChIP-Seq_LNCAP_Human1.35348189
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29533217
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27223591
59IGF1R_20145208_ChIP-Seq_DFB_Human1.26667609
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.26068574
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22258413
62KDM5A_27292631_Chip-Seq_BREAST_Human1.18775895
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14741650
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14103652
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.13688766
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12426396
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07031543
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04367028
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.04094191
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03590222
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01277299
72ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96487045
73SOX2_16153702_ChIP-ChIP_HESCs_Human0.96289672
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95658756
75IRF1_19129219_ChIP-ChIP_H3396_Human0.94295748
76TAF15_26573619_Chip-Seq_HEK293_Human0.91070763
77TP53_22573176_ChIP-Seq_HFKS_Human0.90857912
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90547689
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89584582
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86606698
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84550983
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83960003
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83028574
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81970962
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81238998
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81214571
87P300_19829295_ChIP-Seq_ESCs_Human0.81189722
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80037274
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78828364
90NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78630375
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75798721
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75353665
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.75056067
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.73959998
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72767397
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72422383
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72371512
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70495755
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70295132
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69397525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.16463970
2MP0010094_abnormal_chromosome_stability3.80881062
3MP0003693_abnormal_embryo_hatching3.49391375
4MP0004957_abnormal_blastocyst_morpholog3.05334246
5MP0003806_abnormal_nucleotide_metabolis2.84203773
6MP0003111_abnormal_nucleus_morphology2.79870233
7MP0003718_maternal_effect2.57602062
8MP0008877_abnormal_DNA_methylation2.54532236
9MP0006292_abnormal_olfactory_placode2.41068007
10MP0003077_abnormal_cell_cycle2.39135436
11MP0008932_abnormal_embryonic_tissue2.35093822
12MP0006036_abnormal_mitochondrial_physio2.34803269
13MP0002102_abnormal_ear_morphology2.32250400
14MP0008007_abnormal_cellular_replicative2.29404420
15MP0009697_abnormal_copulation2.28467441
16MP0003786_premature_aging2.24972684
17MP0003646_muscle_fatigue2.20268467
18MP0002837_dystrophic_cardiac_calcinosis2.10710776
19MP0008057_abnormal_DNA_replication2.07005479
20MP0004145_abnormal_muscle_electrophysio2.06317534
21MP0003186_abnormal_redox_activity2.02868138
22MP0006072_abnormal_retinal_apoptosis1.98216114
23MP0000372_irregular_coat_pigmentation1.97659420
24MP0001529_abnormal_vocalization1.94562902
25MP0003941_abnormal_skin_development1.84055676
26MP0006035_abnormal_mitochondrial_morpho1.81594226
27MP0002938_white_spotting1.80820285
28MP0001188_hyperpigmentation1.69685947
29MP0000749_muscle_degeneration1.58399839
30MP0008789_abnormal_olfactory_epithelium1.54559373
31MP0001293_anophthalmia1.51902630
32MP0002160_abnormal_reproductive_system1.51064785
33MP0003567_abnormal_fetal_cardiomyocyte1.42592280
34MP0004215_abnormal_myocardial_fiber1.37135234
35MP0004147_increased_porphyrin_level1.35150329
36MP0009379_abnormal_foot_pigmentation1.29914919
37MP0004142_abnormal_muscle_tone1.26159701
38MP0002163_abnormal_gland_morphology1.24736992
39MP0003937_abnormal_limbs/digits/tail_de1.22242710
40MP0002210_abnormal_sex_determination1.20588601
41MP0008995_early_reproductive_senescence1.13362549
42MP0003890_abnormal_embryonic-extraembry1.12938758
43MP0003121_genomic_imprinting1.12607765
44MP0010030_abnormal_orbit_morphology1.11544967
45MP0003136_yellow_coat_color1.10613253
46MP0006276_abnormal_autonomic_nervous1.10128112
47MP0005253_abnormal_eye_physiology1.08236576
48MP0001929_abnormal_gametogenesis1.07242852
49MP0002736_abnormal_nociception_after1.05701128
50MP0005084_abnormal_gallbladder_morpholo1.04765914
51MP0002234_abnormal_pharynx_morphology1.04128017
52MP0009046_muscle_twitch1.01227763
53MP0005389_reproductive_system_phenotype1.01161140
54MP0003787_abnormal_imprinting1.00606392
55MP0008872_abnormal_physiological_respon0.98657623
56MP0001485_abnormal_pinna_reflex0.97614906
57MP0005266_abnormal_metabolism0.97380541
58MP0000631_abnormal_neuroendocrine_gland0.96260885
59MP0000358_abnormal_cell_content/0.96014943
60MP0000049_abnormal_middle_ear0.95717982
61MP0001697_abnormal_embryo_size0.94881595
62MP0000653_abnormal_sex_gland0.94678214
63MP0003123_paternal_imprinting0.94429173
64MP0005551_abnormal_eye_electrophysiolog0.93664026
65MP0001145_abnormal_male_reproductive0.92614214
66MP0000350_abnormal_cell_proliferation0.91999211
67MP0003137_abnormal_impulse_conducting0.91675791
68MP0002095_abnormal_skin_pigmentation0.87415938
69MP0002638_abnormal_pupillary_reflex0.87114120
70MP0003195_calcinosis0.86684223
71MP0005394_taste/olfaction_phenotype0.84944875
72MP0005499_abnormal_olfactory_system0.84944875
73MP0001984_abnormal_olfaction0.84944406
74MP0001730_embryonic_growth_arrest0.84837647
75MP0005408_hypopigmentation0.82540946
76MP0005075_abnormal_melanosome_morpholog0.82071219
77MP0003011_delayed_dark_adaptation0.81162599
78MP0002751_abnormal_autonomic_nervous0.80300979
79MP0001764_abnormal_homeostasis0.80280712
80MP0004133_heterotaxia0.78939875
81MP0002090_abnormal_vision0.78191508
82MP0000647_abnormal_sebaceous_gland0.77400679
83MP0002085_abnormal_embryonic_tissue0.76077368
84MP0002084_abnormal_developmental_patter0.75957404
85MP0002277_abnormal_respiratory_mucosa0.75778910
86MP0001672_abnormal_embryogenesis/_devel0.75735474
87MP0005380_embryogenesis_phenotype0.75735474
88MP0001286_abnormal_eye_development0.75710925
89MP0010307_abnormal_tumor_latency0.74856893
90MP0003698_abnormal_male_reproductive0.73696788
91MP0003755_abnormal_palate_morphology0.72494693
92MP0003119_abnormal_digestive_system0.71125839
93MP0005395_other_phenotype0.70905134
94MP0004084_abnormal_cardiac_muscle0.70766885
95MP0003221_abnormal_cardiomyocyte_apopto0.69431134
96MP0002233_abnormal_nose_morphology0.68357621
97MP0002269_muscular_atrophy0.68233708
98MP0000313_abnormal_cell_death0.68013106
99MP0001119_abnormal_female_reproductive0.66967831
100MP0003880_abnormal_central_pattern0.66314001

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.05607114
2Abnormal mitochondria in muscle tissue (HP:0008316)4.54823432
3Acute encephalopathy (HP:0006846)4.54360444
4Mitochondrial inheritance (HP:0001427)4.23945579
5Progressive macrocephaly (HP:0004481)4.21485415
6Increased CSF lactate (HP:0002490)4.14088290
7Hepatocellular necrosis (HP:0001404)3.67854686
8Increased hepatocellular lipid droplets (HP:0006565)3.53949511
9Hepatic necrosis (HP:0002605)3.45208962
10Cerebral edema (HP:0002181)3.43405433
11Lipid accumulation in hepatocytes (HP:0006561)3.31573106
12Increased serum lactate (HP:0002151)3.08947537
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00686705
14Abnormality of alanine metabolism (HP:0010916)3.00686705
15Hyperalaninemia (HP:0003348)3.00686705
16Lactic acidosis (HP:0003128)2.93521921
173-Methylglutaconic aciduria (HP:0003535)2.93403848
18Birth length less than 3rd percentile (HP:0003561)2.90256341
19Abnormality of the labia minora (HP:0012880)2.76194392
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75146940
21Chromsome breakage (HP:0040012)2.73639689
22Renal Fanconi syndrome (HP:0001994)2.72094102
23Methylmalonic acidemia (HP:0002912)2.70392042
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62631863
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62631863
26Colon cancer (HP:0003003)2.61146593
27Meckel diverticulum (HP:0002245)2.60077089
28Respiratory failure (HP:0002878)2.59363473
29Pancreatic cysts (HP:0001737)2.59228765
30Type I transferrin isoform profile (HP:0003642)2.57997037
31Exercise intolerance (HP:0003546)2.57726249
32Molar tooth sign on MRI (HP:0002419)2.57201609
33Abnormality of midbrain morphology (HP:0002418)2.57201609
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.55292120
35Abnormality of the ileum (HP:0001549)2.54567392
36Increased intramyocellular lipid droplets (HP:0012240)2.50628225
37Increased serum pyruvate (HP:0003542)2.41739030
38Optic disc pallor (HP:0000543)2.37165725
39Methylmalonic aciduria (HP:0012120)2.34629741
40Nemaline bodies (HP:0003798)2.33594410
41Abnormality of methionine metabolism (HP:0010901)2.30324812
42Pancreatic fibrosis (HP:0100732)2.30227036
43Abnormality of chromosome stability (HP:0003220)2.30185543
44Abnormal number of erythroid precursors (HP:0012131)2.29942279
45Leukodystrophy (HP:0002415)2.29713124
46Abnormality of glycolysis (HP:0004366)2.29060885
47Abnormality of the preputium (HP:0100587)2.23699114
48Aplastic anemia (HP:0001915)2.22877053
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18995428
50Lethargy (HP:0001254)2.18668726
51Reticulocytopenia (HP:0001896)2.17135022
52Abnormality of serum amino acid levels (HP:0003112)2.15604870
53Abnormality of cells of the erythroid lineage (HP:0012130)2.13897790
54Abnormal protein glycosylation (HP:0012346)2.12716929
55Abnormal glycosylation (HP:0012345)2.12716929
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12716929
57Abnormal protein N-linked glycosylation (HP:0012347)2.12716929
58Muscle fiber inclusion bodies (HP:0100299)2.12275599
59Macrocytic anemia (HP:0001972)2.11619290
60Exertional dyspnea (HP:0002875)2.11424681
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09610359
62Congenital, generalized hypertrichosis (HP:0004540)2.08456892
63True hermaphroditism (HP:0010459)2.01739917
64Increased muscle lipid content (HP:0009058)2.00701257
65Abnormality of the anterior horn cell (HP:0006802)1.98223477
66Degeneration of anterior horn cells (HP:0002398)1.98223477
67Cerebral hypomyelination (HP:0006808)1.97809893
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96072935
69Small intestinal stenosis (HP:0012848)1.93101243
70Duodenal stenosis (HP:0100867)1.93101243
71Respiratory difficulties (HP:0002880)1.92482100
72CNS demyelination (HP:0007305)1.91637344
73Abnormal lung lobation (HP:0002101)1.89582717
74Medial flaring of the eyebrow (HP:0010747)1.89044845
75Triphalangeal thumb (HP:0001199)1.88965231
76Hyperglycinemia (HP:0002154)1.88404192
77X-linked dominant inheritance (HP:0001423)1.87286565
78Nephronophthisis (HP:0000090)1.87244371
79Renal cortical cysts (HP:0000803)1.83778929
80Absent thumb (HP:0009777)1.83419991
81Volvulus (HP:0002580)1.80344009
82Sclerocornea (HP:0000647)1.79764213
83Abnormality of placental membranes (HP:0011409)1.79688178
84Amniotic constriction ring (HP:0009775)1.79688178
85Sloping forehead (HP:0000340)1.79004859
86Exercise-induced muscle cramps (HP:0003710)1.76096359
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75620883
88Horseshoe kidney (HP:0000085)1.75516734
89Abnormality of the pons (HP:0007361)1.74826802
90Abnormality of the duodenum (HP:0002246)1.73168016
91Abnormality of renal resorption (HP:0011038)1.72181326
92Abnormality of the renal cortex (HP:0011035)1.72155071
93Neoplasm of the adrenal gland (HP:0100631)1.72020470
94Reduced antithrombin III activity (HP:0001976)1.71155163
95Pancytopenia (HP:0001876)1.70209495
96Pendular nystagmus (HP:0012043)1.69683432
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68352758
98Hypoplasia of the pons (HP:0012110)1.67882541
99Pancreatic islet-cell hyperplasia (HP:0004510)1.66603978
100Abnormality of homocysteine metabolism (HP:0010919)1.65225528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.10130350
2VRK22.80506544
3STK162.74914793
4SRPK12.68928898
5CDC72.63939469
6NEK12.63254882
7ZAK2.49797773
8EIF2AK32.44894145
9TSSK62.41458547
10TRIM282.36124320
11EIF2AK12.31082013
12PBK2.27079495
13NUAK12.23304423
14MST42.18191245
15BMPR1B2.14634963
16PLK42.13545726
17PLK32.10351303
18TTK2.08402392
19MKNK22.03754939
20WEE11.92540109
21NME11.88610733
22MAP4K21.81968863
23WNK31.81930168
24VRK11.77801630
25OBSCN1.67737758
26FRK1.67156633
27BRSK21.62584384
28PDK21.56176439
29MKNK11.53360723
30BCKDK1.52991674
31PLK11.50700348
32TAF11.32429819
33TNIK1.16425453
34NME21.15872802
35CCNB11.12125498
36ACVR1B1.11194764
37TLK11.10578041
38PLK21.08381824
39PNCK1.01676951
40ATR1.00937523
41ERBB31.00824665
42GRK10.99174471
43ADRBK20.97167466
44CHEK20.95544801
45CSNK1G30.94795658
46CSNK1G10.94742759
47PINK10.91933325
48MAPKAPK50.91875865
49WNK40.91391606
50AURKB0.91391561
51DYRK20.87782582
52MAP3K40.87515902
53PHKG20.87418480
54PHKG10.87418480
55BCR0.84618704
56CSNK1G20.82672749
57EIF2AK20.80034969
58BRSK10.78025897
59OXSR10.74858737
60CSNK1A1L0.71875874
61INSRR0.70481255
62LIMK10.69532101
63MAP3K120.66957398
64ATM0.66356329
65CHEK10.63335053
66CSNK2A10.62930368
67STK390.62844400
68MAP2K70.62763315
69TIE10.61721259
70MAPK130.60517780
71CSNK2A20.59250261
72TGFBR10.57830208
73NEK20.56747581
74PASK0.54451738
75CSNK1E0.54250282
76MAPKAPK30.53408120
77STK30.53088110
78DYRK30.52627298
79AURKA0.51823208
80BRAF0.49119264
81CDK190.47586281
82PRKCI0.47410769
83STK38L0.46797828
84MUSK0.42909111
85ILK0.42246756
86STK40.41713105
87RPS6KA50.40470081
88PRKCG0.39400109
89CDK80.39211322
90CDK10.36319018
91ALK0.34853399
92PAK30.34407279
93DAPK10.33937224
94ERBB40.33367828
95CDK70.32053263
96PRKDC0.31289352
97RPS6KA40.30973656
98CSNK1A10.30270048
99ABL20.27899100
100CDK20.27524826

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.07738699
2Oxidative phosphorylation_Homo sapiens_hsa001903.61254471
3Parkinsons disease_Homo sapiens_hsa050123.22221563
4Protein export_Homo sapiens_hsa030603.13955223
5Ribosome_Homo sapiens_hsa030103.13578817
6RNA polymerase_Homo sapiens_hsa030203.05080614
7Mismatch repair_Homo sapiens_hsa034303.04487599
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98616557
9DNA replication_Homo sapiens_hsa030302.95137956
10Homologous recombination_Homo sapiens_hsa034402.75779903
11Non-homologous end-joining_Homo sapiens_hsa034502.29044133
12Huntingtons disease_Homo sapiens_hsa050162.28243347
13Spliceosome_Homo sapiens_hsa030402.10786472
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10331770
15Alzheimers disease_Homo sapiens_hsa050102.07997653
16Nucleotide excision repair_Homo sapiens_hsa034202.03678614
17Fanconi anemia pathway_Homo sapiens_hsa034602.03136310
18Basal transcription factors_Homo sapiens_hsa030221.98599035
19RNA transport_Homo sapiens_hsa030131.96209758
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96124370
21One carbon pool by folate_Homo sapiens_hsa006701.93965024
22RNA degradation_Homo sapiens_hsa030181.88208751
23Base excision repair_Homo sapiens_hsa034101.78618040
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76623482
25Pyrimidine metabolism_Homo sapiens_hsa002401.75220209
26Propanoate metabolism_Homo sapiens_hsa006401.61291838
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57446619
28Cardiac muscle contraction_Homo sapiens_hsa042601.49650682
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43051825
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40271424
31Purine metabolism_Homo sapiens_hsa002301.38275018
32Cell cycle_Homo sapiens_hsa041101.35997904
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32921851
34Pyruvate metabolism_Homo sapiens_hsa006201.27863188
35Fatty acid elongation_Homo sapiens_hsa000621.25490546
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23946199
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21447244
38Selenocompound metabolism_Homo sapiens_hsa004501.16221292
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14964140
40Sulfur relay system_Homo sapiens_hsa041221.08476393
41Steroid biosynthesis_Homo sapiens_hsa001000.99998285
42Folate biosynthesis_Homo sapiens_hsa007900.96039424
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94359223
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92500253
45Sulfur metabolism_Homo sapiens_hsa009200.89756908
46Vitamin B6 metabolism_Homo sapiens_hsa007500.81592762
47Phototransduction_Homo sapiens_hsa047440.80931860
48Butanoate metabolism_Homo sapiens_hsa006500.80552317
49Glutathione metabolism_Homo sapiens_hsa004800.77752092
50Metabolic pathways_Homo sapiens_hsa011000.76106737
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74051446
52mRNA surveillance pathway_Homo sapiens_hsa030150.71550518
53Carbon metabolism_Homo sapiens_hsa012000.70524567
54Regulation of autophagy_Homo sapiens_hsa041400.67078853
55Peroxisome_Homo sapiens_hsa041460.66941766
56Oocyte meiosis_Homo sapiens_hsa041140.65404352
57p53 signaling pathway_Homo sapiens_hsa041150.64829828
58Caffeine metabolism_Homo sapiens_hsa002320.63568341
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63254964
60Nitrogen metabolism_Homo sapiens_hsa009100.59400852
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56054140
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54943243
63Tryptophan metabolism_Homo sapiens_hsa003800.54300096
64Biosynthesis of amino acids_Homo sapiens_hsa012300.53107486
65Collecting duct acid secretion_Homo sapiens_hsa049660.51525849
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44621109
67Fatty acid metabolism_Homo sapiens_hsa012120.42926891
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42708117
69Arginine and proline metabolism_Homo sapiens_hsa003300.39431637
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37665088
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36723586
72Fatty acid degradation_Homo sapiens_hsa000710.36375152
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35886177
74beta-Alanine metabolism_Homo sapiens_hsa004100.33961034
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32410599
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.30116156
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29018216
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28643169
79Epstein-Barr virus infection_Homo sapiens_hsa051690.28583398
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27995999
81Linoleic acid metabolism_Homo sapiens_hsa005910.27017048
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.25564783
83Chemical carcinogenesis_Homo sapiens_hsa052040.22185010
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.21490223
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21479521
86Olfactory transduction_Homo sapiens_hsa047400.19759564
87N-Glycan biosynthesis_Homo sapiens_hsa005100.19425297
88Nicotine addiction_Homo sapiens_hsa050330.18565117
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18188934
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18018544
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17580649
92Retinol metabolism_Homo sapiens_hsa008300.16982560
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16885084
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15178671
95Hedgehog signaling pathway_Homo sapiens_hsa043400.15027975
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13268307
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13251726
98Circadian rhythm_Homo sapiens_hsa047100.12602028
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.11187139
100Vitamin digestion and absorption_Homo sapiens_hsa049770.10994756

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