

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.27941103 |
| 2 | proteasome assembly (GO:0043248) | 4.99660772 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 4.66685325 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.66685325 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.63537111 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.46712861 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.44123435 |
| 8 | chromatin remodeling at centromere (GO:0031055) | 4.19354156 |
| 9 | cullin deneddylation (GO:0010388) | 4.08555171 |
| 10 | CENP-A containing nucleosome assembly (GO:0034080) | 4.08148470 |
| 11 | respiratory electron transport chain (GO:0022904) | 4.02495036 |
| 12 | DNA replication checkpoint (GO:0000076) | 4.00257697 |
| 13 | protein complex biogenesis (GO:0070271) | 3.96880760 |
| 14 | electron transport chain (GO:0022900) | 3.96213794 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.92170199 |
| 16 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.91900112 |
| 17 | NADH dehydrogenase complex assembly (GO:0010257) | 3.91900112 |
| 18 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.91900112 |
| 19 | maturation of 5.8S rRNA (GO:0000460) | 3.87000294 |
| 20 | protein deneddylation (GO:0000338) | 3.84546069 |
| 21 | termination of RNA polymerase III transcription (GO:0006386) | 3.81845177 |
| 22 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.81845177 |
| 23 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.78540203 |
| 24 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.61625688 |
| 25 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.59520847 |
| 26 | pseudouridine synthesis (GO:0001522) | 3.59142822 |
| 27 | DNA double-strand break processing (GO:0000729) | 3.58532560 |
| 28 | protein neddylation (GO:0045116) | 3.58270241 |
| 29 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.57186362 |
| 30 | respiratory chain complex IV assembly (GO:0008535) | 3.56608113 |
| 31 | histone exchange (GO:0043486) | 3.52105420 |
| 32 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.52096821 |
| 33 | regulation of mitochondrial translation (GO:0070129) | 3.50729411 |
| 34 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.47188922 |
| 35 | negative regulation of ligase activity (GO:0051352) | 3.47188922 |
| 36 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.47076808 |
| 37 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.45897015 |
| 38 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.45897015 |
| 39 | protein targeting to mitochondrion (GO:0006626) | 3.43572904 |
| 40 | spliceosomal snRNP assembly (GO:0000387) | 3.42860922 |
| 41 | ribosome assembly (GO:0042255) | 3.39153485 |
| 42 | rRNA modification (GO:0000154) | 3.37790777 |
| 43 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.37569379 |
| 44 | DNA damage response, detection of DNA damage (GO:0042769) | 3.30671137 |
| 45 | purine nucleobase biosynthetic process (GO:0009113) | 3.27230098 |
| 46 | oxidative phosphorylation (GO:0006119) | 3.26131880 |
| 47 | protein localization to mitochondrion (GO:0070585) | 3.25735934 |
| 48 | ribosomal large subunit biogenesis (GO:0042273) | 3.25626700 |
| 49 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.22840913 |
| 50 | rRNA processing (GO:0006364) | 3.22315660 |
| 51 | cytochrome complex assembly (GO:0017004) | 3.21197599 |
| 52 | establishment of protein localization to mitochondrion (GO:0072655) | 3.19675940 |
| 53 | maturation of SSU-rRNA (GO:0030490) | 3.19419213 |
| 54 | IMP biosynthetic process (GO:0006188) | 3.19292253 |
| 55 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.18593534 |
| 56 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.14586254 |
| 57 | protein K6-linked ubiquitination (GO:0085020) | 3.13361946 |
| 58 | rRNA metabolic process (GO:0016072) | 3.13360950 |
| 59 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.12801790 |
| 60 | replication fork processing (GO:0031297) | 3.12595826 |
| 61 | DNA replication-independent nucleosome organization (GO:0034724) | 3.11950508 |
| 62 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.11950508 |
| 63 | kinetochore organization (GO:0051383) | 3.11530496 |
| 64 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.11443947 |
| 65 | nucleobase biosynthetic process (GO:0046112) | 3.11260158 |
| 66 | cellular component biogenesis (GO:0044085) | 3.10358518 |
| 67 | DNA strand elongation (GO:0022616) | 3.09962389 |
| 68 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.09276827 |
| 69 | histone mRNA metabolic process (GO:0008334) | 3.08484627 |
| 70 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.07747962 |
| 71 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.07163055 |
| 72 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.07163055 |
| 73 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.07163055 |
| 74 | peptidyl-histidine modification (GO:0018202) | 3.07151587 |
| 75 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.03798284 |
| 76 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.03798284 |
| 77 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.02628243 |
| 78 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.02628243 |
| 79 | protein localization to kinetochore (GO:0034501) | 3.02321846 |
| 80 | positive regulation of ligase activity (GO:0051351) | 3.01804662 |
| 81 | mitotic metaphase plate congression (GO:0007080) | 3.01074118 |
| 82 | translation (GO:0006412) | 3.00977198 |
| 83 | establishment of integrated proviral latency (GO:0075713) | 3.00344321 |
| 84 | kinetochore assembly (GO:0051382) | 3.00176031 |
| 85 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.98595726 |
| 86 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.97465267 |
| 87 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.97465267 |
| 88 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.96530523 |
| 89 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.96202092 |
| 90 | tRNA processing (GO:0008033) | 2.95978601 |
| 91 | protein-cofactor linkage (GO:0018065) | 2.95947143 |
| 92 | DNA deamination (GO:0045006) | 2.94049044 |
| 93 | ribosome biogenesis (GO:0042254) | 2.93895535 |
| 94 | mitochondrial RNA metabolic process (GO:0000959) | 2.92295410 |
| 95 | rRNA methylation (GO:0031167) | 2.88981143 |
| 96 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.88762903 |
| 97 | tRNA metabolic process (GO:0006399) | 2.87638191 |
| 98 | IMP metabolic process (GO:0046040) | 2.87293431 |
| 99 | intracellular protein transmembrane import (GO:0044743) | 2.84688402 |
| 100 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.84423914 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.32849594 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.60788970 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.51135983 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.17180672 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.56923631 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.47230607 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.36498598 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.35812762 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.32819380 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.17274574 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.96126922 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.93022717 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.89681694 |
| 14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.72831948 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.64161046 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.49755080 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.40077970 |
| 18 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.39073079 |
| 19 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.38934762 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.35747170 |
| 21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33217737 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.25949946 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.13409524 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.09608590 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.08555259 |
| 26 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.07549163 |
| 27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.03543562 |
| 28 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.03163481 |
| 29 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.00095128 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.96856174 |
| 31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.94618927 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.91585886 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.90189092 |
| 34 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.89741955 |
| 35 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.87422471 |
| 36 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.85597243 |
| 37 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.84874109 |
| 38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.80011886 |
| 39 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.76623947 |
| 40 | VDR_22108803_ChIP-Seq_LS180_Human | 1.76190661 |
| 41 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.75812548 |
| 42 | EWS_26573619_Chip-Seq_HEK293_Human | 1.65176040 |
| 43 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.59864954 |
| 44 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.57489877 |
| 45 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.55314611 |
| 46 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.54748694 |
| 47 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.52537821 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.52246499 |
| 49 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.50215458 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.49011647 |
| 51 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.45654628 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.44375760 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.40138376 |
| 54 | FUS_26573619_Chip-Seq_HEK293_Human | 1.36886002 |
| 55 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.36761063 |
| 56 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.35348189 |
| 57 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.29533217 |
| 58 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.27223591 |
| 59 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.26667609 |
| 60 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.26068574 |
| 61 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.22258413 |
| 62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.18775895 |
| 63 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.14741650 |
| 64 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.14103652 |
| 65 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13688766 |
| 66 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.12426396 |
| 67 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.07031543 |
| 68 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.04367028 |
| 69 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.04094191 |
| 70 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03590222 |
| 71 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.01277299 |
| 72 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.96487045 |
| 73 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.96289672 |
| 74 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95658756 |
| 75 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.94295748 |
| 76 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.91070763 |
| 77 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.90857912 |
| 78 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.90547689 |
| 79 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.89584582 |
| 80 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.86606698 |
| 81 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.84550983 |
| 82 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.83960003 |
| 83 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.83028574 |
| 84 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.81970962 |
| 85 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.81238998 |
| 86 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.81214571 |
| 87 | P300_19829295_ChIP-Seq_ESCs_Human | 0.81189722 |
| 88 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.80037274 |
| 89 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.78828364 |
| 90 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.78630375 |
| 91 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.75798721 |
| 92 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.75353665 |
| 93 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.75056067 |
| 94 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.73959998 |
| 95 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.72767397 |
| 96 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72422383 |
| 97 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72371512 |
| 98 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.70495755 |
| 99 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.70295132 |
| 100 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.69397525 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.16463970 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.80881062 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.49391375 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.05334246 |
| 5 | MP0003806_abnormal_nucleotide_metabolis | 2.84203773 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.79870233 |
| 7 | MP0003718_maternal_effect | 2.57602062 |
| 8 | MP0008877_abnormal_DNA_methylation | 2.54532236 |
| 9 | MP0006292_abnormal_olfactory_placode | 2.41068007 |
| 10 | MP0003077_abnormal_cell_cycle | 2.39135436 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.35093822 |
| 12 | MP0006036_abnormal_mitochondrial_physio | 2.34803269 |
| 13 | MP0002102_abnormal_ear_morphology | 2.32250400 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.29404420 |
| 15 | MP0009697_abnormal_copulation | 2.28467441 |
| 16 | MP0003786_premature_aging | 2.24972684 |
| 17 | MP0003646_muscle_fatigue | 2.20268467 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 2.10710776 |
| 19 | MP0008057_abnormal_DNA_replication | 2.07005479 |
| 20 | MP0004145_abnormal_muscle_electrophysio | 2.06317534 |
| 21 | MP0003186_abnormal_redox_activity | 2.02868138 |
| 22 | MP0006072_abnormal_retinal_apoptosis | 1.98216114 |
| 23 | MP0000372_irregular_coat_pigmentation | 1.97659420 |
| 24 | MP0001529_abnormal_vocalization | 1.94562902 |
| 25 | MP0003941_abnormal_skin_development | 1.84055676 |
| 26 | MP0006035_abnormal_mitochondrial_morpho | 1.81594226 |
| 27 | MP0002938_white_spotting | 1.80820285 |
| 28 | MP0001188_hyperpigmentation | 1.69685947 |
| 29 | MP0000749_muscle_degeneration | 1.58399839 |
| 30 | MP0008789_abnormal_olfactory_epithelium | 1.54559373 |
| 31 | MP0001293_anophthalmia | 1.51902630 |
| 32 | MP0002160_abnormal_reproductive_system | 1.51064785 |
| 33 | MP0003567_abnormal_fetal_cardiomyocyte | 1.42592280 |
| 34 | MP0004215_abnormal_myocardial_fiber | 1.37135234 |
| 35 | MP0004147_increased_porphyrin_level | 1.35150329 |
| 36 | MP0009379_abnormal_foot_pigmentation | 1.29914919 |
| 37 | MP0004142_abnormal_muscle_tone | 1.26159701 |
| 38 | MP0002163_abnormal_gland_morphology | 1.24736992 |
| 39 | MP0003937_abnormal_limbs/digits/tail_de | 1.22242710 |
| 40 | MP0002210_abnormal_sex_determination | 1.20588601 |
| 41 | MP0008995_early_reproductive_senescence | 1.13362549 |
| 42 | MP0003890_abnormal_embryonic-extraembry | 1.12938758 |
| 43 | MP0003121_genomic_imprinting | 1.12607765 |
| 44 | MP0010030_abnormal_orbit_morphology | 1.11544967 |
| 45 | MP0003136_yellow_coat_color | 1.10613253 |
| 46 | MP0006276_abnormal_autonomic_nervous | 1.10128112 |
| 47 | MP0005253_abnormal_eye_physiology | 1.08236576 |
| 48 | MP0001929_abnormal_gametogenesis | 1.07242852 |
| 49 | MP0002736_abnormal_nociception_after | 1.05701128 |
| 50 | MP0005084_abnormal_gallbladder_morpholo | 1.04765914 |
| 51 | MP0002234_abnormal_pharynx_morphology | 1.04128017 |
| 52 | MP0009046_muscle_twitch | 1.01227763 |
| 53 | MP0005389_reproductive_system_phenotype | 1.01161140 |
| 54 | MP0003787_abnormal_imprinting | 1.00606392 |
| 55 | MP0008872_abnormal_physiological_respon | 0.98657623 |
| 56 | MP0001485_abnormal_pinna_reflex | 0.97614906 |
| 57 | MP0005266_abnormal_metabolism | 0.97380541 |
| 58 | MP0000631_abnormal_neuroendocrine_gland | 0.96260885 |
| 59 | MP0000358_abnormal_cell_content/ | 0.96014943 |
| 60 | MP0000049_abnormal_middle_ear | 0.95717982 |
| 61 | MP0001697_abnormal_embryo_size | 0.94881595 |
| 62 | MP0000653_abnormal_sex_gland | 0.94678214 |
| 63 | MP0003123_paternal_imprinting | 0.94429173 |
| 64 | MP0005551_abnormal_eye_electrophysiolog | 0.93664026 |
| 65 | MP0001145_abnormal_male_reproductive | 0.92614214 |
| 66 | MP0000350_abnormal_cell_proliferation | 0.91999211 |
| 67 | MP0003137_abnormal_impulse_conducting | 0.91675791 |
| 68 | MP0002095_abnormal_skin_pigmentation | 0.87415938 |
| 69 | MP0002638_abnormal_pupillary_reflex | 0.87114120 |
| 70 | MP0003195_calcinosis | 0.86684223 |
| 71 | MP0005394_taste/olfaction_phenotype | 0.84944875 |
| 72 | MP0005499_abnormal_olfactory_system | 0.84944875 |
| 73 | MP0001984_abnormal_olfaction | 0.84944406 |
| 74 | MP0001730_embryonic_growth_arrest | 0.84837647 |
| 75 | MP0005408_hypopigmentation | 0.82540946 |
| 76 | MP0005075_abnormal_melanosome_morpholog | 0.82071219 |
| 77 | MP0003011_delayed_dark_adaptation | 0.81162599 |
| 78 | MP0002751_abnormal_autonomic_nervous | 0.80300979 |
| 79 | MP0001764_abnormal_homeostasis | 0.80280712 |
| 80 | MP0004133_heterotaxia | 0.78939875 |
| 81 | MP0002090_abnormal_vision | 0.78191508 |
| 82 | MP0000647_abnormal_sebaceous_gland | 0.77400679 |
| 83 | MP0002085_abnormal_embryonic_tissue | 0.76077368 |
| 84 | MP0002084_abnormal_developmental_patter | 0.75957404 |
| 85 | MP0002277_abnormal_respiratory_mucosa | 0.75778910 |
| 86 | MP0001672_abnormal_embryogenesis/_devel | 0.75735474 |
| 87 | MP0005380_embryogenesis_phenotype | 0.75735474 |
| 88 | MP0001286_abnormal_eye_development | 0.75710925 |
| 89 | MP0010307_abnormal_tumor_latency | 0.74856893 |
| 90 | MP0003698_abnormal_male_reproductive | 0.73696788 |
| 91 | MP0003755_abnormal_palate_morphology | 0.72494693 |
| 92 | MP0003119_abnormal_digestive_system | 0.71125839 |
| 93 | MP0005395_other_phenotype | 0.70905134 |
| 94 | MP0004084_abnormal_cardiac_muscle | 0.70766885 |
| 95 | MP0003221_abnormal_cardiomyocyte_apopto | 0.69431134 |
| 96 | MP0002233_abnormal_nose_morphology | 0.68357621 |
| 97 | MP0002269_muscular_atrophy | 0.68233708 |
| 98 | MP0000313_abnormal_cell_death | 0.68013106 |
| 99 | MP0001119_abnormal_female_reproductive | 0.66967831 |
| 100 | MP0003880_abnormal_central_pattern | 0.66314001 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.05607114 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.54823432 |
| 3 | Acute encephalopathy (HP:0006846) | 4.54360444 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.23945579 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.21485415 |
| 6 | Increased CSF lactate (HP:0002490) | 4.14088290 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.67854686 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.53949511 |
| 9 | Hepatic necrosis (HP:0002605) | 3.45208962 |
| 10 | Cerebral edema (HP:0002181) | 3.43405433 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.31573106 |
| 12 | Increased serum lactate (HP:0002151) | 3.08947537 |
| 13 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.00686705 |
| 14 | Abnormality of alanine metabolism (HP:0010916) | 3.00686705 |
| 15 | Hyperalaninemia (HP:0003348) | 3.00686705 |
| 16 | Lactic acidosis (HP:0003128) | 2.93521921 |
| 17 | 3-Methylglutaconic aciduria (HP:0003535) | 2.93403848 |
| 18 | Birth length less than 3rd percentile (HP:0003561) | 2.90256341 |
| 19 | Abnormality of the labia minora (HP:0012880) | 2.76194392 |
| 20 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.75146940 |
| 21 | Chromsome breakage (HP:0040012) | 2.73639689 |
| 22 | Renal Fanconi syndrome (HP:0001994) | 2.72094102 |
| 23 | Methylmalonic acidemia (HP:0002912) | 2.70392042 |
| 24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.62631863 |
| 25 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.62631863 |
| 26 | Colon cancer (HP:0003003) | 2.61146593 |
| 27 | Meckel diverticulum (HP:0002245) | 2.60077089 |
| 28 | Respiratory failure (HP:0002878) | 2.59363473 |
| 29 | Pancreatic cysts (HP:0001737) | 2.59228765 |
| 30 | Type I transferrin isoform profile (HP:0003642) | 2.57997037 |
| 31 | Exercise intolerance (HP:0003546) | 2.57726249 |
| 32 | Molar tooth sign on MRI (HP:0002419) | 2.57201609 |
| 33 | Abnormality of midbrain morphology (HP:0002418) | 2.57201609 |
| 34 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.55292120 |
| 35 | Abnormality of the ileum (HP:0001549) | 2.54567392 |
| 36 | Increased intramyocellular lipid droplets (HP:0012240) | 2.50628225 |
| 37 | Increased serum pyruvate (HP:0003542) | 2.41739030 |
| 38 | Optic disc pallor (HP:0000543) | 2.37165725 |
| 39 | Methylmalonic aciduria (HP:0012120) | 2.34629741 |
| 40 | Nemaline bodies (HP:0003798) | 2.33594410 |
| 41 | Abnormality of methionine metabolism (HP:0010901) | 2.30324812 |
| 42 | Pancreatic fibrosis (HP:0100732) | 2.30227036 |
| 43 | Abnormality of chromosome stability (HP:0003220) | 2.30185543 |
| 44 | Abnormal number of erythroid precursors (HP:0012131) | 2.29942279 |
| 45 | Leukodystrophy (HP:0002415) | 2.29713124 |
| 46 | Abnormality of glycolysis (HP:0004366) | 2.29060885 |
| 47 | Abnormality of the preputium (HP:0100587) | 2.23699114 |
| 48 | Aplastic anemia (HP:0001915) | 2.22877053 |
| 49 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.18995428 |
| 50 | Lethargy (HP:0001254) | 2.18668726 |
| 51 | Reticulocytopenia (HP:0001896) | 2.17135022 |
| 52 | Abnormality of serum amino acid levels (HP:0003112) | 2.15604870 |
| 53 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.13897790 |
| 54 | Abnormal protein glycosylation (HP:0012346) | 2.12716929 |
| 55 | Abnormal glycosylation (HP:0012345) | 2.12716929 |
| 56 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.12716929 |
| 57 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.12716929 |
| 58 | Muscle fiber inclusion bodies (HP:0100299) | 2.12275599 |
| 59 | Macrocytic anemia (HP:0001972) | 2.11619290 |
| 60 | Exertional dyspnea (HP:0002875) | 2.11424681 |
| 61 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.09610359 |
| 62 | Congenital, generalized hypertrichosis (HP:0004540) | 2.08456892 |
| 63 | True hermaphroditism (HP:0010459) | 2.01739917 |
| 64 | Increased muscle lipid content (HP:0009058) | 2.00701257 |
| 65 | Abnormality of the anterior horn cell (HP:0006802) | 1.98223477 |
| 66 | Degeneration of anterior horn cells (HP:0002398) | 1.98223477 |
| 67 | Cerebral hypomyelination (HP:0006808) | 1.97809893 |
| 68 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.96072935 |
| 69 | Small intestinal stenosis (HP:0012848) | 1.93101243 |
| 70 | Duodenal stenosis (HP:0100867) | 1.93101243 |
| 71 | Respiratory difficulties (HP:0002880) | 1.92482100 |
| 72 | CNS demyelination (HP:0007305) | 1.91637344 |
| 73 | Abnormal lung lobation (HP:0002101) | 1.89582717 |
| 74 | Medial flaring of the eyebrow (HP:0010747) | 1.89044845 |
| 75 | Triphalangeal thumb (HP:0001199) | 1.88965231 |
| 76 | Hyperglycinemia (HP:0002154) | 1.88404192 |
| 77 | X-linked dominant inheritance (HP:0001423) | 1.87286565 |
| 78 | Nephronophthisis (HP:0000090) | 1.87244371 |
| 79 | Renal cortical cysts (HP:0000803) | 1.83778929 |
| 80 | Absent thumb (HP:0009777) | 1.83419991 |
| 81 | Volvulus (HP:0002580) | 1.80344009 |
| 82 | Sclerocornea (HP:0000647) | 1.79764213 |
| 83 | Abnormality of placental membranes (HP:0011409) | 1.79688178 |
| 84 | Amniotic constriction ring (HP:0009775) | 1.79688178 |
| 85 | Sloping forehead (HP:0000340) | 1.79004859 |
| 86 | Exercise-induced muscle cramps (HP:0003710) | 1.76096359 |
| 87 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.75620883 |
| 88 | Horseshoe kidney (HP:0000085) | 1.75516734 |
| 89 | Abnormality of the pons (HP:0007361) | 1.74826802 |
| 90 | Abnormality of the duodenum (HP:0002246) | 1.73168016 |
| 91 | Abnormality of renal resorption (HP:0011038) | 1.72181326 |
| 92 | Abnormality of the renal cortex (HP:0011035) | 1.72155071 |
| 93 | Neoplasm of the adrenal gland (HP:0100631) | 1.72020470 |
| 94 | Reduced antithrombin III activity (HP:0001976) | 1.71155163 |
| 95 | Pancytopenia (HP:0001876) | 1.70209495 |
| 96 | Pendular nystagmus (HP:0012043) | 1.69683432 |
| 97 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.68352758 |
| 98 | Hypoplasia of the pons (HP:0012110) | 1.67882541 |
| 99 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.66603978 |
| 100 | Abnormality of homocysteine metabolism (HP:0010919) | 1.65225528 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.10130350 |
| 2 | VRK2 | 2.80506544 |
| 3 | STK16 | 2.74914793 |
| 4 | SRPK1 | 2.68928898 |
| 5 | CDC7 | 2.63939469 |
| 6 | NEK1 | 2.63254882 |
| 7 | ZAK | 2.49797773 |
| 8 | EIF2AK3 | 2.44894145 |
| 9 | TSSK6 | 2.41458547 |
| 10 | TRIM28 | 2.36124320 |
| 11 | EIF2AK1 | 2.31082013 |
| 12 | PBK | 2.27079495 |
| 13 | NUAK1 | 2.23304423 |
| 14 | MST4 | 2.18191245 |
| 15 | BMPR1B | 2.14634963 |
| 16 | PLK4 | 2.13545726 |
| 17 | PLK3 | 2.10351303 |
| 18 | TTK | 2.08402392 |
| 19 | MKNK2 | 2.03754939 |
| 20 | WEE1 | 1.92540109 |
| 21 | NME1 | 1.88610733 |
| 22 | MAP4K2 | 1.81968863 |
| 23 | WNK3 | 1.81930168 |
| 24 | VRK1 | 1.77801630 |
| 25 | OBSCN | 1.67737758 |
| 26 | FRK | 1.67156633 |
| 27 | BRSK2 | 1.62584384 |
| 28 | PDK2 | 1.56176439 |
| 29 | MKNK1 | 1.53360723 |
| 30 | BCKDK | 1.52991674 |
| 31 | PLK1 | 1.50700348 |
| 32 | TAF1 | 1.32429819 |
| 33 | TNIK | 1.16425453 |
| 34 | NME2 | 1.15872802 |
| 35 | CCNB1 | 1.12125498 |
| 36 | ACVR1B | 1.11194764 |
| 37 | TLK1 | 1.10578041 |
| 38 | PLK2 | 1.08381824 |
| 39 | PNCK | 1.01676951 |
| 40 | ATR | 1.00937523 |
| 41 | ERBB3 | 1.00824665 |
| 42 | GRK1 | 0.99174471 |
| 43 | ADRBK2 | 0.97167466 |
| 44 | CHEK2 | 0.95544801 |
| 45 | CSNK1G3 | 0.94795658 |
| 46 | CSNK1G1 | 0.94742759 |
| 47 | PINK1 | 0.91933325 |
| 48 | MAPKAPK5 | 0.91875865 |
| 49 | WNK4 | 0.91391606 |
| 50 | AURKB | 0.91391561 |
| 51 | DYRK2 | 0.87782582 |
| 52 | MAP3K4 | 0.87515902 |
| 53 | PHKG2 | 0.87418480 |
| 54 | PHKG1 | 0.87418480 |
| 55 | BCR | 0.84618704 |
| 56 | CSNK1G2 | 0.82672749 |
| 57 | EIF2AK2 | 0.80034969 |
| 58 | BRSK1 | 0.78025897 |
| 59 | OXSR1 | 0.74858737 |
| 60 | CSNK1A1L | 0.71875874 |
| 61 | INSRR | 0.70481255 |
| 62 | LIMK1 | 0.69532101 |
| 63 | MAP3K12 | 0.66957398 |
| 64 | ATM | 0.66356329 |
| 65 | CHEK1 | 0.63335053 |
| 66 | CSNK2A1 | 0.62930368 |
| 67 | STK39 | 0.62844400 |
| 68 | MAP2K7 | 0.62763315 |
| 69 | TIE1 | 0.61721259 |
| 70 | MAPK13 | 0.60517780 |
| 71 | CSNK2A2 | 0.59250261 |
| 72 | TGFBR1 | 0.57830208 |
| 73 | NEK2 | 0.56747581 |
| 74 | PASK | 0.54451738 |
| 75 | CSNK1E | 0.54250282 |
| 76 | MAPKAPK3 | 0.53408120 |
| 77 | STK3 | 0.53088110 |
| 78 | DYRK3 | 0.52627298 |
| 79 | AURKA | 0.51823208 |
| 80 | BRAF | 0.49119264 |
| 81 | CDK19 | 0.47586281 |
| 82 | PRKCI | 0.47410769 |
| 83 | STK38L | 0.46797828 |
| 84 | MUSK | 0.42909111 |
| 85 | ILK | 0.42246756 |
| 86 | STK4 | 0.41713105 |
| 87 | RPS6KA5 | 0.40470081 |
| 88 | PRKCG | 0.39400109 |
| 89 | CDK8 | 0.39211322 |
| 90 | CDK1 | 0.36319018 |
| 91 | ALK | 0.34853399 |
| 92 | PAK3 | 0.34407279 |
| 93 | DAPK1 | 0.33937224 |
| 94 | ERBB4 | 0.33367828 |
| 95 | CDK7 | 0.32053263 |
| 96 | PRKDC | 0.31289352 |
| 97 | RPS6KA4 | 0.30973656 |
| 98 | CSNK1A1 | 0.30270048 |
| 99 | ABL2 | 0.27899100 |
| 100 | CDK2 | 0.27524826 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.07738699 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.61254471 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.22221563 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.13955223 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 3.13578817 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.05080614 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 3.04487599 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.98616557 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.95137956 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.75779903 |
| 11 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.29044133 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.28243347 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.10786472 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.10331770 |
| 15 | Alzheimers disease_Homo sapiens_hsa05010 | 2.07997653 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.03678614 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.03136310 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.98599035 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.96209758 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.96124370 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.93965024 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.88208751 |
| 23 | Base excision repair_Homo sapiens_hsa03410 | 1.78618040 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.76623482 |
| 25 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.75220209 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.61291838 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.57446619 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.49650682 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.43051825 |
| 30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.40271424 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.38275018 |
| 32 | Cell cycle_Homo sapiens_hsa04110 | 1.35997904 |
| 33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.32921851 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.27863188 |
| 35 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.25490546 |
| 36 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.23946199 |
| 37 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.21447244 |
| 38 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.16221292 |
| 39 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.14964140 |
| 40 | Sulfur relay system_Homo sapiens_hsa04122 | 1.08476393 |
| 41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.99998285 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.96039424 |
| 43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.94359223 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.92500253 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.89756908 |
| 46 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.81592762 |
| 47 | Phototransduction_Homo sapiens_hsa04744 | 0.80931860 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.80552317 |
| 49 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.77752092 |
| 50 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76106737 |
| 51 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.74051446 |
| 52 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.71550518 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.70524567 |
| 54 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.67078853 |
| 55 | Peroxisome_Homo sapiens_hsa04146 | 0.66941766 |
| 56 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.65404352 |
| 57 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.64829828 |
| 58 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.63568341 |
| 59 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.63254964 |
| 60 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59400852 |
| 61 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56054140 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54943243 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.54300096 |
| 64 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.53107486 |
| 65 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.51525849 |
| 66 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44621109 |
| 67 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42926891 |
| 68 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.42708117 |
| 69 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.39431637 |
| 70 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.37665088 |
| 71 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.36723586 |
| 72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.36375152 |
| 73 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.35886177 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.33961034 |
| 75 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.32410599 |
| 76 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.30116156 |
| 77 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.29018216 |
| 78 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.28643169 |
| 79 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.28583398 |
| 80 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27995999 |
| 81 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27017048 |
| 82 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.25564783 |
| 83 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.22185010 |
| 84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.21490223 |
| 85 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.21479521 |
| 86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19759564 |
| 87 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.19425297 |
| 88 | Nicotine addiction_Homo sapiens_hsa05033 | 0.18565117 |
| 89 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.18188934 |
| 90 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.18018544 |
| 91 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.17580649 |
| 92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.16982560 |
| 93 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.16885084 |
| 94 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.15178671 |
| 95 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.15027975 |
| 96 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.13268307 |
| 97 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.13251726 |
| 98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.12602028 |
| 99 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.11187139 |
| 100 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.10994756 |

