UTP14A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of nuclear cell cycle DNA replication (GO:0033262)6.68132888
2aminoglycoside antibiotic metabolic process (GO:0030647)6.44604385
3protein localization to kinetochore (GO:0034501)6.30544228
4maintenance of protein location in nucleus (GO:0051457)6.29212015
5somite rostral/caudal axis specification (GO:0032525)6.07483073
6regulation of telomere maintenance via telomerase (GO:0032210)5.96632803
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.95376472
8negative regulation of epidermis development (GO:0045683)5.92814198
9regulation of mammary gland epithelial cell proliferation (GO:0033599)5.92525983
10histone H4-K12 acetylation (GO:0043983)5.46600918
11negative regulation of telomerase activity (GO:0051974)5.45922376
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.40846075
13histone H4-K5 acetylation (GO:0043981)5.38103240
14histone H4-K8 acetylation (GO:0043982)5.38103240
15rRNA transcription (GO:0009303)5.36407142
16regulation of response to osmotic stress (GO:0047484)5.19561643
17negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.16880349
18mitotic sister chromatid segregation (GO:0000070)5.15433770
19rRNA methylation (GO:0031167)5.12188435
20regulation of MHC class I biosynthetic process (GO:0045343)5.00946304
21nuclear pore complex assembly (GO:0051292)5.00844275
22ribosome assembly (GO:0042255)4.94176189
23rRNA modification (GO:0000154)4.89200210
24mitotic metaphase plate congression (GO:0007080)4.82717192
25positive regulation of DNA-dependent DNA replication (GO:2000105)4.82484382
26negative regulation of epidermal cell differentiation (GO:0045605)4.79634234
27protein localization to chromosome, centromeric region (GO:0071459)4.76693884
28muscle organ morphogenesis (GO:0048644)4.74696128
29notochord development (GO:0030903)4.71659113
30DNA strand elongation involved in DNA replication (GO:0006271)4.70347013
31DNA replication-dependent nucleosome assembly (GO:0006335)4.68440364
32DNA replication-dependent nucleosome organization (GO:0034723)4.68440364
33negative regulation of telomere maintenance (GO:0032205)4.62272353
34DNA strand elongation (GO:0022616)4.58406833
35DNA replication checkpoint (GO:0000076)4.52365952
36heterochromatin organization (GO:0070828)4.45847959
37nuclear pore organization (GO:0006999)4.42581141
38regulation of translation in response to stress (GO:0043555)4.35961222
39sister chromatid segregation (GO:0000819)4.32767254
40establishment of integrated proviral latency (GO:0075713)4.29837601
41interferon-gamma production (GO:0032609)4.26320779
42telomere maintenance via semi-conservative replication (GO:0032201)4.21084077
43primitive streak formation (GO:0090009)4.20174246
44regulation of cilium movement (GO:0003352)4.19885028
45mitotic nuclear envelope disassembly (GO:0007077)4.19326481
46chromatin assembly (GO:0031497)4.15303266
47ribosomal large subunit biogenesis (GO:0042273)4.14813410
48viral mRNA export from host cell nucleus (GO:0046784)4.09640509
49metaphase plate congression (GO:0051310)4.04597289
50histone H4-K16 acetylation (GO:0043984)4.02971419
51cell fate commitment involved in formation of primary germ layer (GO:0060795)4.02121280
52cytidine deamination (GO:0009972)4.00188047
53cytidine metabolic process (GO:0046087)4.00188047
54cytidine catabolic process (GO:0006216)4.00188047
55phenol-containing compound catabolic process (GO:0019336)3.99129968
56nucleoside transmembrane transport (GO:1901642)3.91648878
57membrane disassembly (GO:0030397)3.91006401
58nuclear envelope disassembly (GO:0051081)3.91006401
59regulation of telomere maintenance (GO:0032204)3.85722202
60regulation of apoptotic process involved in morphogenesis (GO:1902337)3.85292018
61maturation of SSU-rRNA (GO:0030490)3.82892574
62ribosome biogenesis (GO:0042254)3.82211208
63pore complex assembly (GO:0046931)3.81227651
64CENP-A containing nucleosome assembly (GO:0034080)3.81136214
65branching involved in mammary gland duct morphogenesis (GO:0060444)3.81064833
66proteasome assembly (GO:0043248)3.80472562
67telomere maintenance via recombination (GO:0000722)3.77381112
68quinone metabolic process (GO:1901661)3.77053158
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75187271
70folic acid-containing compound biosynthetic process (GO:0009396)3.72146807
71DNA damage response, detection of DNA damage (GO:0042769)3.67073970
72chromatin remodeling at centromere (GO:0031055)3.66375788
73mitotic recombination (GO:0006312)3.65239752
74response to dietary excess (GO:0002021)3.64280113
75hormone catabolic process (GO:0042447)3.64205090
76intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.61802909
77* rRNA processing (GO:0006364)3.59818265
78mitotic sister chromatid cohesion (GO:0007064)3.59381276
79establishment of chromosome localization (GO:0051303)3.58979942
80regulation of translational fidelity (GO:0006450)3.58583922
81positive regulation of chromosome segregation (GO:0051984)3.55248523
82IMP biosynthetic process (GO:0006188)3.53912044
83cullin deneddylation (GO:0010388)3.49963856
84pre-miRNA processing (GO:0031054)3.48360147
85intestinal epithelial cell development (GO:0060576)3.47777504
86* rRNA metabolic process (GO:0016072)3.42629474
87purine nucleobase biosynthetic process (GO:0009113)3.42007046
88non-recombinational repair (GO:0000726)3.40709359
89double-strand break repair via nonhomologous end joining (GO:0006303)3.40709359
90spliceosomal snRNP assembly (GO:0000387)3.40203615
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39062027
92formation of translation preinitiation complex (GO:0001731)3.39044077
93establishment of viral latency (GO:0019043)3.36804313
94regulation of telomerase activity (GO:0051972)3.36110953
95regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.36030748
96regulation of gene silencing by RNA (GO:0060966)3.35998407
97regulation of posttranscriptional gene silencing (GO:0060147)3.35998407
98regulation of gene silencing by miRNA (GO:0060964)3.35998407
99pseudouridine synthesis (GO:0001522)3.35735655
100nucleobase biosynthetic process (GO:0046112)3.34875089
101DNA duplex unwinding (GO:0032508)3.34349538
102ribosomal small subunit biogenesis (GO:0042274)3.31756320
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31238258
104DNA geometric change (GO:0032392)3.30886265
105tRNA aminoacylation for protein translation (GO:0006418)3.30532934
106regulation of spindle organization (GO:0090224)3.29376236
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27813087
108regulation of DNA-dependent DNA replication (GO:0090329)3.26787073
109mRNA stabilization (GO:0048255)3.25637776
110RNA stabilization (GO:0043489)3.25637776
111maintenance of protein localization in organelle (GO:0072595)3.24809824
112amino acid activation (GO:0043038)3.23673749
113tRNA aminoacylation (GO:0043039)3.23673749
114telomere maintenance via telomere lengthening (GO:0010833)3.23076119
115mitochondrion distribution (GO:0048311)3.22154060
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21768128
117regulation of mitotic spindle organization (GO:0060236)3.21298949
118DNA replication-independent nucleosome organization (GO:0034724)3.15571354
119DNA replication-independent nucleosome assembly (GO:0006336)3.15571354
120nucleotide-excision repair, DNA gap filling (GO:0006297)3.13478125
121coenzyme catabolic process (GO:0009109)3.13346267
122protein deneddylation (GO:0000338)3.12769588
123regulation of double-strand break repair (GO:2000779)3.12738476
124IMP metabolic process (GO:0046040)3.12466422
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12196484
126maturation of 5.8S rRNA (GO:0000460)3.11335914
127cellular component biogenesis (GO:0044085)3.10987237
128mitotic chromosome condensation (GO:0007076)3.09321756
129cardiovascular system development (GO:0072358)3.08269946
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08102992
131nucleobase-containing small molecule interconversion (GO:0015949)3.07537749
132histone exchange (GO:0043486)3.07262017
133transcription from mitochondrial promoter (GO:0006390)3.06144346
134nuclear envelope organization (GO:0006998)3.05705087
135ribonucleoprotein complex biogenesis (GO:0022613)3.05007590
136mitochondrial RNA metabolic process (GO:0000959)3.04931076
137negative regulation of ligase activity (GO:0051352)3.04461336
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04461336
139DNA topological change (GO:0006265)3.03796646
140apoptotic DNA fragmentation (GO:0006309)3.03543155
141kinetochore organization (GO:0051383)3.02496568
142spindle checkpoint (GO:0031577)3.02470325
143DNA unwinding involved in DNA replication (GO:0006268)3.02231625
144GDP-mannose metabolic process (GO:0019673)3.01580484
145regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.01071611
146regulation of translational termination (GO:0006449)2.99791551
147regulation of centriole replication (GO:0046599)2.99311111
148regulation of chromosome segregation (GO:0051983)2.98501048
149regulation of RNA export from nucleus (GO:0046831)2.97841566
150positive regulation of protein deacetylation (GO:0090312)2.97261323
151mitochondrial DNA replication (GO:0006264)2.96798960
152G1/S transition of mitotic cell cycle (GO:0000082)2.95278739
153cell cycle G1/S phase transition (GO:0044843)2.95278739
154retinoic acid receptor signaling pathway (GO:0048384)2.95225760
155transcription-coupled nucleotide-excision repair (GO:0006283)2.94648698
156bone trabecula formation (GO:0060346)2.93625557
157DNA replication initiation (GO:0006270)2.93486688
158trophectodermal cell differentiation (GO:0001829)2.93062183
159attachment of spindle microtubules to kinetochore (GO:0008608)2.92413695
160nucleoside transport (GO:0015858)2.91196200
161spliceosomal tri-snRNP complex assembly (GO:0000244)2.91041041
162regulation of mitochondrial translation (GO:0070129)2.89179111
163chromosome segregation (GO:0007059)2.88659716
164regulation of centrosome cycle (GO:0046605)2.88656029
165ribosomal small subunit assembly (GO:0000028)2.88471016
166chromatin assembly or disassembly (GO:0006333)2.88112213
167negative regulation of chromosome segregation (GO:0051985)2.87963200
168negative regulation of gene silencing (GO:0060969)2.87725147
169mitotic spindle checkpoint (GO:0071174)2.87627854
170negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.86220935
171negative regulation of mRNA processing (GO:0050686)2.85276065
172anterior/posterior axis specification (GO:0009948)2.83381070
173regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83004769
174negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.82223379
175microtubule severing (GO:0051013)2.81870124
176polyketide metabolic process (GO:0030638)10.1327284
177doxorubicin metabolic process (GO:0044598)10.1327284
178daunorubicin metabolic process (GO:0044597)10.1327284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.35968465
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.35968465
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.35968465
4E2F7_22180533_ChIP-Seq_HELA_Human6.16841937
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.98893202
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.19760840
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.67061303
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18441494
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.17132737
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.84768527
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.81447901
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.75068225
13TCF3_18692474_ChIP-Seq_MESCs_Mouse2.50773292
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.48442007
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.41468427
16* MYC_18555785_ChIP-Seq_MESCs_Mouse2.39362437
17DCP1A_22483619_ChIP-Seq_HELA_Human2.33176760
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29704194
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27782823
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26568241
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26431714
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.26220055
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.17366272
24NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.14534179
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09105550
26IRF1_19129219_ChIP-ChIP_H3396_Human2.04565864
27POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.97234060
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96681197
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89755377
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89343320
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86672104
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83319470
33NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.82409145
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81567663
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79975760
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79264814
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77800913
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75238946
39* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71423040
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70455704
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67202589
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.66459834
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65203824
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65006838
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59496095
46* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59220369
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58465645
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58272976
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57738382
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56973283
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56355702
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.55019081
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.53068051
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52689239
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.52582253
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51788050
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48720628
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.46130002
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43309173
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42354757
61NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42344477
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41782193
63NANOG_18692474_ChIP-Seq_MEFs_Mouse1.41697569
64* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40969141
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40846352
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39795684
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.39369753
68POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.36881473
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36741772
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35350495
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33867894
72TFEB_21752829_ChIP-Seq_HELA_Human1.32959276
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32592895
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31971334
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30613575
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25461809
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24212590
78E2F1_17053090_ChIP-ChIP_MCF-7_Human1.23758707
79* NOTCH1_21737748_ChIP-Seq_TLL_Human1.22757959
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21785030
81SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21358810
82PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.21230144
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16240491
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15997317
85FOXP3_21729870_ChIP-Seq_TREG_Human1.13713578
86NANOG_16518401_ChIP-PET_MESCs_Mouse1.13485859
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13204705
88MYC_22102868_ChIP-Seq_BL_Human1.13060578
89* NANOG_16153702_ChIP-ChIP_HESCs_Human1.12802190
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11984950
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11607636
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11227341
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07036763
94E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06726487
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05086875
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04178550
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03960973
98ZNF263_19887448_ChIP-Seq_K562_Human1.03518117
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03203013
100* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02618157
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.02604981
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01522444
103ETS1_20019798_ChIP-Seq_JURKAT_Human1.01322023
104NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99955170
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98385421
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.97992529
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95941447
108MYC_18940864_ChIP-ChIP_HL60_Human0.94903870
109GABP_17652178_ChIP-ChIP_JURKAT_Human0.94903134
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94283904
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94123562
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.94003234
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93544435
114XRN2_22483619_ChIP-Seq_HELA_Human0.92458262
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91277832
116CHD1_26751641_Chip-Seq_LNCaP_Human0.89810528
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.89048559
118MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88962702
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87324391
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84065532
121AR_21909140_ChIP-Seq_LNCAP_Human0.83820330
122TTF2_22483619_ChIP-Seq_HELA_Human0.82666852
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81615660
124VDR_23849224_ChIP-Seq_CD4+_Human0.81433057
125ELF5_23300383_ChIP-Seq_T47D_Human0.80788949
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80782060
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80457600
128NCOR1_26117541_ChIP-Seq_K562_Human0.80241432
129KDM5A_27292631_Chip-Seq_BREAST_Human0.80215776
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79840324
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78734489
132KAP1_27257070_Chip-Seq_ESCs_Mouse0.78140440
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77660570
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77188634
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76274748
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.75649752
137* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74233520
138TP53_22127205_ChIP-Seq_IMR90_Human0.73570750
139* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72661259
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.71740218
141EGR1_19374776_ChIP-ChIP_THP-1_Human0.71585952
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.71377589
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.69364955
144CIITA_25753668_ChIP-Seq_RAJI_Human0.69143405
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68503030
146GABP_19822575_ChIP-Seq_HepG2_Human0.68420499
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.67356111
148ELK1_19687146_ChIP-ChIP_HELA_Human0.65448221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.58873216
2MP0002254_reproductive_system_inflammat4.27928952
3MP0003011_delayed_dark_adaptation4.11450563
4MP0004264_abnormal_extraembryonic_tissu4.06477239
5MP0008057_abnormal_DNA_replication4.05807407
6MP0003890_abnormal_embryonic-extraembry3.75381235
7MP0005499_abnormal_olfactory_system3.24632207
8MP0005394_taste/olfaction_phenotype3.24632207
9MP0003718_maternal_effect3.19683636
10MP0004957_abnormal_blastocyst_morpholog3.17002603
11MP0005075_abnormal_melanosome_morpholog3.04067620
12MP0003122_maternal_imprinting2.56058919
13MP0003121_genomic_imprinting2.54778115
14MP0004858_abnormal_nervous_system2.35925466
15MP0002332_abnormal_exercise_endurance2.32657285
16MP0003806_abnormal_nucleotide_metabolis2.30668017
17MP0005257_abnormal_intraocular_pressure2.25768496
18MP0006035_abnormal_mitochondrial_morpho2.18519134
19MP0003077_abnormal_cell_cycle2.06146495
20MP0003938_abnormal_ear_development1.97935194
21MP0010352_gastrointestinal_tract_polyps1.97286975
22MP0002277_abnormal_respiratory_mucosa1.95524044
23MP0001672_abnormal_embryogenesis/_devel1.93834056
24MP0005380_embryogenesis_phenotype1.93834056
25MP0003111_abnormal_nucleus_morphology1.88378060
26MP0002653_abnormal_ependyma_morphology1.87849694
27MP0010307_abnormal_tumor_latency1.86865549
28MP0009697_abnormal_copulation1.84817271
29MP0003705_abnormal_hypodermis_morpholog1.83588438
30MP0010094_abnormal_chromosome_stability1.79155326
31MP0003123_paternal_imprinting1.78651917
32MP0002088_abnormal_embryonic_growth/wei1.75599188
33MP0003984_embryonic_growth_retardation1.74298335
34MP0001293_anophthalmia1.73392368
35MP0000350_abnormal_cell_proliferation1.66475379
36MP0000678_abnormal_parathyroid_gland1.60959656
37MP0003186_abnormal_redox_activity1.59654575
38MP0008789_abnormal_olfactory_epithelium1.56481830
39MP0002877_abnormal_melanocyte_morpholog1.56090910
40MP0002396_abnormal_hematopoietic_system1.53327832
41MP0010030_abnormal_orbit_morphology1.52859424
42MP0010234_abnormal_vibrissa_follicle1.50644529
43MP0002127_abnormal_cardiovascular_syste1.50331205
44MP0003941_abnormal_skin_development1.48598540
45MP0005501_abnormal_skin_physiology1.47643148
46MP0002092_abnormal_eye_morphology1.43928707
47MP0003787_abnormal_imprinting1.43712413
48MP0008007_abnormal_cellular_replicative1.35107056
49MP0000762_abnormal_tongue_morphology1.34887941
50MP0002085_abnormal_embryonic_tissue1.34769404
51MP0003693_abnormal_embryo_hatching1.34031511
52MP0002086_abnormal_extraembryonic_tissu1.33458684
53MP0000049_abnormal_middle_ear1.32671104
54MP0008961_abnormal_basal_metabolism1.29185921
55MP0003183_abnormal_peptide_metabolism1.28930319
56MP0006036_abnormal_mitochondrial_physio1.28619507
57MP0002932_abnormal_joint_morphology1.27683187
58MP0004133_heterotaxia1.25963374
59MP0002796_impaired_skin_barrier1.24733894
60MP0004381_abnormal_hair_follicle1.24670441
61MP0004808_abnormal_hematopoietic_stem1.22434691
62MP0002233_abnormal_nose_morphology1.19538566
63MP0008932_abnormal_embryonic_tissue1.18836837
64MP0002084_abnormal_developmental_patter1.18505812
65MP0008058_abnormal_DNA_repair1.16728439
66MP0005395_other_phenotype1.15690691
67MP0006082_CNS_inflammation1.15669874
68MP0003315_abnormal_perineum_morphology1.15626892
69MP0000490_abnormal_crypts_of1.15130910
70MP0001849_ear_inflammation1.14098549
71MP0004233_abnormal_muscle_weight1.13878530
72MP0003119_abnormal_digestive_system1.10816999
73MP0005266_abnormal_metabolism1.10668840
74MP0004185_abnormal_adipocyte_glucose1.10201609
75MP0002132_abnormal_respiratory_system1.09956922
76MP0004197_abnormal_fetal_growth/weight/1.09684322
77MP0002114_abnormal_axial_skeleton1.08358423
78MP0001730_embryonic_growth_arrest1.08082414
79MP0000432_abnormal_head_morphology1.06965501
80MP0000313_abnormal_cell_death1.06698850
81MP0002210_abnormal_sex_determination1.05600718
82MP0003786_premature_aging1.04080513
83MP0008877_abnormal_DNA_methylation1.03201840
84MP0003755_abnormal_palate_morphology1.02826136
85MP0000428_abnormal_craniofacial_morphol1.01960231
86MP0009333_abnormal_splenocyte_physiolog1.01712137
87MP0009672_abnormal_birth_weight0.99576721
88MP0001697_abnormal_embryo_size0.96646789
89MP0001929_abnormal_gametogenesis0.96352702
90MP0003935_abnormal_craniofacial_develop0.94697631
91MP0005621_abnormal_cell_physiology0.94288897
92MP0005391_vision/eye_phenotype0.93002062
93MP0005076_abnormal_cell_differentiation0.92586984
94MP0003221_abnormal_cardiomyocyte_apopto0.91870712
95MP0003937_abnormal_limbs/digits/tail_de0.91021586
96MP0001661_extended_life_span0.90718737
97MP0008770_decreased_survivor_rate0.90155352
98MP0001286_abnormal_eye_development0.88705368
99MP0005408_hypopigmentation0.88613962
100MP0001881_abnormal_mammary_gland0.88150051
101MP0003136_yellow_coat_color0.88107298
102MP0002080_prenatal_lethality0.88099280
103MP0002751_abnormal_autonomic_nervous0.87519968
104MP0005451_abnormal_body_composition0.85737270
105MP0001853_heart_inflammation0.84429593
106MP0003699_abnormal_female_reproductive0.84016969
107MP0005248_abnormal_Harderian_gland0.83598636
108MP0002060_abnormal_skin_morphology0.83224927
109MP0000537_abnormal_urethra_morphology0.80755506
110MP0001145_abnormal_male_reproductive0.80000987
111MP0002970_abnormal_white_adipose0.79791225
112MP0009703_decreased_birth_body0.79524083
113MP0003950_abnormal_plasma_membrane0.79481390
114MP0000627_abnormal_mammary_gland0.79057079
115MP0002116_abnormal_craniofacial_bone0.77252820
116MP0002269_muscular_atrophy0.76987249
117MP0003943_abnormal_hepatobiliary_system0.76679626
118MP0002160_abnormal_reproductive_system0.75274738
119MP0005508_abnormal_skeleton_morphology0.75224545
120MP0002925_abnormal_cardiovascular_devel0.74939042
121MP0001727_abnormal_embryo_implantation0.74707963
122MP0000703_abnormal_thymus_morphology0.74630905
123MP0000653_abnormal_sex_gland0.74170914
124MP0003566_abnormal_cell_adhesion0.73637378
125MP0003763_abnormal_thymus_physiology0.72679931
126MP0002098_abnormal_vibrissa_morphology0.72108978
127MP0001216_abnormal_epidermal_layer0.71407540
128MP0008260_abnormal_autophagy0.70571558
129MP0003283_abnormal_digestive_organ0.69499117
130MP0001348_abnormal_lacrimal_gland0.67982911
131MP0003137_abnormal_impulse_conducting0.67874878
132MP0002249_abnormal_larynx_morphology0.66265450
133MP0002111_abnormal_tail_morphology0.65730715
134MP0003828_pulmonary_edema0.63319090
135MP0001764_abnormal_homeostasis0.62818019
136MP0000383_abnormal_hair_follicle0.62271006
137MP0000750_abnormal_muscle_regeneration0.62121428
138MP0002019_abnormal_tumor_incidence0.61456436
139MP0003453_abnormal_keratinocyte_physiol0.60489137
140MP0002006_tumorigenesis0.60201407
141MP0000358_abnormal_cell_content/0.60084712
142MP0002938_white_spotting0.59694155
143MP0005384_cellular_phenotype0.59563987
144MP0002081_perinatal_lethality0.59298685
145MP0003861_abnormal_nervous_system0.58505727
146MP0005023_abnormal_wound_healing0.57104055
147MP0000579_abnormal_nail_morphology0.57095389
148MP0003448_altered_tumor_morphology0.56240008
149MP0002161_abnormal_fertility/fecundity0.55156121
150MP0001119_abnormal_female_reproductive0.54893762
151MP0010771_integument_phenotype0.54879756
152MP0001243_abnormal_dermal_layer0.54029877
153MP0002398_abnormal_bone_marrow0.49020889

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.24188597
2Hypochromic microcytic anemia (HP:0004840)6.18132815
3Hepatoblastoma (HP:0002884)5.11912724
4Multiple enchondromatosis (HP:0005701)5.03059577
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.69215036
6Rib fusion (HP:0000902)4.52615294
7Ependymoma (HP:0002888)4.31123017
8Chromsome breakage (HP:0040012)4.13986224
9Nephroblastoma (Wilms tumor) (HP:0002667)4.08605938
10Abnormality of the lower motor neuron (HP:0002366)4.03279581
11Embryonal renal neoplasm (HP:0011794)3.78716261
12Rhabdomyosarcoma (HP:0002859)3.76004923
13Neoplasm of striated muscle (HP:0009728)3.75253767
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.47358214
15Hypoplasia of the fovea (HP:0007750)3.47358214
16Testicular atrophy (HP:0000029)3.27385925
17Reticulocytopenia (HP:0001896)3.23053195
18Rectovaginal fistula (HP:0000143)3.21510710
19Rectal fistula (HP:0100590)3.21510710
20Fused cervical vertebrae (HP:0002949)3.21446252
21Abnormal lung lobation (HP:0002101)3.20520870
22Birth length less than 3rd percentile (HP:0003561)3.18015629
23Aplastic anemia (HP:0001915)3.14233213
24Meckel diverticulum (HP:0002245)3.07958126
25Partial duplication of thumb phalanx (HP:0009944)3.00335420
26Abnormality of the astrocytes (HP:0100707)2.98435170
27Astrocytoma (HP:0009592)2.98435170
28Abnormality of cells of the erythroid lineage (HP:0012130)2.91335879
29Abnormality of the ileum (HP:0001549)2.89382747
30Intestinal fistula (HP:0100819)2.89224273
31Abnormality of the salivary glands (HP:0010286)2.88621753
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.86982235
33Trismus (HP:0000211)2.86308660
34Anomalous pulmonary venous return (HP:0010772)2.83841915
35Aplasia/hypoplasia of the humerus (HP:0006507)2.81375884
36Bifid tongue (HP:0010297)2.81269224
37Horizontal nystagmus (HP:0000666)2.71469367
38Impulsivity (HP:0100710)2.70261656
39Short humerus (HP:0005792)2.68224554
40Entropion (HP:0000621)2.67683491
41Hypochromic anemia (HP:0001931)2.67619569
42Increased serum pyruvate (HP:0003542)2.67576630
43Supernumerary spleens (HP:0009799)2.67329802
44Selective tooth agenesis (HP:0001592)2.67038013
45Vaginal fistula (HP:0004320)2.66567419
46Reduced antithrombin III activity (HP:0001976)2.64906496
47Amyotrophic lateral sclerosis (HP:0007354)2.63120202
48Ragged-red muscle fibers (HP:0003200)2.62687492
49Sparse lateral eyebrow (HP:0005338)2.61488776
50Rough bone trabeculation (HP:0100670)2.59923092
51Abnormality of glycolysis (HP:0004366)2.59815597
52Lip pit (HP:0100267)2.59487193
53Partial duplication of the phalanx of hand (HP:0009999)2.58075969
54Preauricular skin tag (HP:0000384)2.57716845
55Abnormality of the anterior horn cell (HP:0006802)2.56586135
56Degeneration of anterior horn cells (HP:0002398)2.56586135
57Abnormality of the fovea (HP:0000493)2.55839824
58Macrocytic anemia (HP:0001972)2.52704778
59Hyperinsulinemic hypoglycemia (HP:0000825)2.52671704
60Abnormal number of erythroid precursors (HP:0012131)2.49032155
61Increased nuchal translucency (HP:0010880)2.44459100
62Abnormal cartilage morphology (HP:0002763)2.41579658
63Abnormality of the pulmonary veins (HP:0011718)2.41173032
64Large earlobe (HP:0009748)2.40826409
65Nasolacrimal duct obstruction (HP:0000579)2.39873673
66Medulloblastoma (HP:0002885)2.39122257
67Increased hepatocellular lipid droplets (HP:0006565)2.38828047
68Horseshoe kidney (HP:0000085)2.38713446
69Shawl scrotum (HP:0000049)2.37416717
70Pendular nystagmus (HP:0012043)2.37161589
71Glioma (HP:0009733)2.36088248
72Periauricular skin pits (HP:0100277)2.35954848
73Preauricular pit (HP:0004467)2.35954848
74Duodenal stenosis (HP:0100867)2.35315281
75Small intestinal stenosis (HP:0012848)2.35315281
76Abnormality of DNA repair (HP:0003254)2.34782419
77Oral leukoplakia (HP:0002745)2.34715695
78Sensory axonal neuropathy (HP:0003390)2.34166349
79Pancytopenia (HP:0001876)2.31509185
80Progressive muscle weakness (HP:0003323)2.31370382
81Abnormality of methionine metabolism (HP:0010901)2.30827049
82Abnormality of chromosome segregation (HP:0002916)2.27611984
83Skin tags (HP:0010609)2.27021293
84Poikiloderma (HP:0001029)2.26877404
85Short middle phalanx of the 5th finger (HP:0004220)2.25822396
86Increased CSF lactate (HP:0002490)2.25364684
87Increased serum lactate (HP:0002151)2.25137120
88Acute myeloid leukemia (HP:0004808)2.23929063
89Progressive external ophthalmoplegia (HP:0000590)2.21950783
90Sparse eyelashes (HP:0000653)2.21249301
91Aplasia/Hypoplasia of the sternum (HP:0006714)2.21117567
92Abnormal mitochondria in muscle tissue (HP:0008316)2.20902155
93Aplasia/Hypoplasia of the macula (HP:0008059)2.20666360
94Abnormality of the umbilical cord (HP:0010881)2.19520958
95Acute necrotizing encephalopathy (HP:0006965)2.19219514
96Abnormality of the preputium (HP:0100587)2.18627732
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18320740
98Proximal placement of thumb (HP:0009623)2.18110925
99Upper limb muscle weakness (HP:0003484)2.15747936
100Acute encephalopathy (HP:0006846)2.14625979
1013-Methylglutaconic aciduria (HP:0003535)2.14549238
102Squamous cell carcinoma (HP:0002860)2.14062407
103Deviation of the thumb (HP:0009603)2.13866769
104Lipid accumulation in hepatocytes (HP:0006561)2.12611335
105Supernumerary ribs (HP:0005815)2.07601993
106Combined immunodeficiency (HP:0005387)2.06469448
107Abnormality of the phalanges of the hallux (HP:0010057)2.06312940
108Generalized hypotonia (HP:0001290)2.06130206
109Abnormal protein glycosylation (HP:0012346)2.06020981
110Abnormal glycosylation (HP:0012345)2.06020981
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06020981
112Abnormal protein N-linked glycosylation (HP:0012347)2.06020981
113Embryonal neoplasm (HP:0002898)2.05922920
114Microvesicular hepatic steatosis (HP:0001414)2.05476351
115Secondary amenorrhea (HP:0000869)2.04985955
116Absent radius (HP:0003974)2.04047259
117Glossoptosis (HP:0000162)2.03543903
118Malignant neoplasm of the central nervous system (HP:0100836)2.00967735
119Deep philtrum (HP:0002002)2.00698048
120Abnormality of the fetal cardiovascular system (HP:0010948)2.00584111
121Abnormal umbilical cord blood vessels (HP:0011403)2.00584111
122Single umbilical artery (HP:0001195)2.00584111
123Duplication of thumb phalanx (HP:0009942)1.99921652
124Abnormality of the labia minora (HP:0012880)1.99260425
125Cheilitis (HP:0100825)1.97983966
126Abnormality of the carotid arteries (HP:0005344)1.97836572
127Facial cleft (HP:0002006)1.97799371
128Upper motor neuron abnormality (HP:0002127)1.97695780
129Pallor (HP:0000980)1.97471961
130Abnormality of small intestinal villus morphology (HP:0011472)1.97335149
131Villous atrophy (HP:0011473)1.97335149
132Abnormalities of placenta or umbilical cord (HP:0001194)1.97065620
133Abnormal trabecular bone morphology (HP:0100671)1.96492905
134Microretrognathia (HP:0000308)1.96381801
135Premature ovarian failure (HP:0008209)1.96377221
136Choanal atresia (HP:0000453)1.96371462
137Type I transferrin isoform profile (HP:0003642)1.95716404
138Cerebral edema (HP:0002181)1.95139182
139Supernumerary bones of the axial skeleton (HP:0009144)1.95103979
140Abnormality of the duodenum (HP:0002246)1.95000499
141Vertebral fusion (HP:0002948)1.94188335
142Microglossia (HP:0000171)1.94130383
143Ureteral duplication (HP:0000073)1.94093923
144Abnormal gallbladder physiology (HP:0012438)1.93741634
145Cholecystitis (HP:0001082)1.93741634
146Short 5th finger (HP:0009237)1.93300353
147Atresia of the external auditory canal (HP:0000413)1.92742538
148Aplasia/Hypoplasia affecting the retina (HP:0008061)1.92449126
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92388145
150Renal Fanconi syndrome (HP:0001994)1.92141232
151Abnormality of the pubic bones (HP:0003172)1.91155215
152Myelodysplasia (HP:0002863)1.90974467
153Volvulus (HP:0002580)1.90154226
154Hyperventilation (HP:0002883)1.89988055
155Increased connective tissue (HP:0009025)1.89949889
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88047103
157Sloping forehead (HP:0000340)1.87902713
158Abnormality of the distal phalanx of the thumb (HP:0009617)1.87146225
159Tongue fasciculations (HP:0001308)1.86401371
160Abnormality of chromosome stability (HP:0003220)1.86300555
161Skin pits (HP:0100276)1.86244186
162Absent forearm bone (HP:0003953)1.86205070
163Aplasia involving forearm bones (HP:0009822)1.86205070
164Abnormal number of incisors (HP:0011064)1.85286865
165Cafe-au-lait spot (HP:0000957)1.83995531
166Cleft eyelid (HP:0000625)1.83353384
167Absent thumb (HP:0009777)1.82675781
168Amniotic constriction ring (HP:0009775)1.78887161
169Abnormality of placental membranes (HP:0011409)1.78887161
170Cutaneous melanoma (HP:0012056)1.76886911
171Overlapping toe (HP:0001845)1.73918018
172Urethral obstruction (HP:0000796)1.73432017
173Hypokinesia (HP:0002375)1.73202558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.76333204
2GRK54.99702784
3GRK64.04014595
4ERN13.78623426
5GRK13.13610210
6TTK3.12957469
7EIF2AK13.09030217
8ADRBK23.04335697
9NME22.91989234
10PBK2.88648242
11CSF1R2.86745217
12VRK22.79483757
13TSSK62.75553991
14EIF2AK32.64886473
15MST42.56540120
16GRK72.55455958
17TYRO32.48884331
18TGFBR22.48714929
19MAPK72.43331479
20STK102.28915461
21SCYL22.15198845
22MATK2.05698977
23PDK22.02230701
24SMG11.90478017
25CDK71.88977131
26MOS1.87619942
27WNK11.80934128
28NME11.71568920
29EPHA21.70858288
30CHEK21.57690846
31PLK11.43942679
32STK161.39989834
33CAMK41.36993579
34TAF11.33921027
35TESK11.30859068
36CDC71.29939982
37AKT31.28791983
38MAP3K81.26749955
39NUAK11.26112179
40BRSK11.24372516
41PRKG21.21835129
42PAK41.19248946
43MST1R1.19175608
44MARK21.15106687
45CHEK11.06157235
46BRAF1.05105166
47EIF2AK21.04211303
48BUB11.04119543
49FGFR31.03348213
50SRPK11.01426732
51ADRBK11.01125718
52HIPK20.97675557
53WEE10.96440169
54NTRK10.94315420
55CLK10.90478991
56ARAF0.90277411
57MAP3K100.86984651
58MAP2K40.84476770
59NEK60.82883866
60EEF2K0.82538285
61STK30.82474846
62AKT20.79678269
63RPS6KB20.78860434
64CCNB10.77600723
65ALK0.77371136
66CDK90.76684401
67NEK20.76153976
68BRD40.75258967
69TRIM280.74367514
70CSK0.71032589
71RPS6KA40.68517221
72ERBB40.66184699
73RAF10.62987675
74MAP2K60.62816529
75CDK20.62410941
76AURKB0.62352188
77MET0.60543702
78PIM20.60118641
79AURKA0.58830491
80ILK0.56693255
81MAP3K90.55633428
82ATM0.55523562
83TESK20.55013808
84PASK0.54426889
85PRKCI0.53832912
86MAPK120.52771565
87DYRK30.51614522
88LATS20.51056907
89CDK40.50802297
90DAPK10.50622351
91STK240.48522271
92MTOR0.48084727
93CDK60.46599431
94MAP3K120.42989548
95LATS10.42889337
96CSNK1E0.42236663
97IKBKB0.41463614
98MAP3K70.40365917
99ATR0.40163730
100TRIB30.39123623
101CDK10.38871338
102LRRK20.36717930
103IRAK20.35521805
104MKNK20.35414384
105DYRK1A0.35061230
106ITK0.33598888
107IGF1R0.31934895
108PAK10.31285543
109PAK20.30495280
110MAPK100.29712811
111VRK10.29302303
112IRAK30.29060315
113PLK40.28727147
114MKNK10.28522789
115MAPK140.27843033
116DYRK20.27233470
117PRKCD0.26447818
118STK40.26155386
119GSK3B0.25730383
120CDK80.25600530
121PRKDC0.24411063
122MAP3K130.23674765
123MAPK10.22944567
124YES10.22770437
125MAPKAPK50.22609865
126CSNK1G30.22094166
127INSR0.21029153
128ERBB20.20710396
129PRPF4B0.19639230
130MELK0.19254180
131CHUK0.19215648
132ZAK0.18720231
133TLK10.18026068
134STK38L0.17180139
135TAOK20.17023471
136MAPK40.16432405
137BLK0.16021648
138PIM10.15586348
139PLK30.13600022
140ACVR1B0.13554291
141BRSK20.12743090
142NEK10.12508455
143AKT10.12025088
144CSNK2A10.11976743
145PRKACB0.11702542
146CSNK1D0.10165194
147CSNK2A20.10164130
148CDK11A0.09727681
149PRKACA0.08954552

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.38460613
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.31245018
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.33922350
4Fructose and mannose metabolism_Homo sapiens_hsa000513.10372617
5Fanconi anemia pathway_Homo sapiens_hsa034602.55797682
6RNA transport_Homo sapiens_hsa030132.53413870
7DNA replication_Homo sapiens_hsa030302.51147562
8Arachidonic acid metabolism_Homo sapiens_hsa005902.44933219
9Mismatch repair_Homo sapiens_hsa034302.42384408
10Ribosome_Homo sapiens_hsa030102.39232186
11Homologous recombination_Homo sapiens_hsa034402.10315407
12Galactose metabolism_Homo sapiens_hsa000522.00179721
13Spliceosome_Homo sapiens_hsa030401.94728118
14One carbon pool by folate_Homo sapiens_hsa006701.94443185
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90726537
16RNA polymerase_Homo sapiens_hsa030201.90626157
17Linoleic acid metabolism_Homo sapiens_hsa005911.89640709
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88235301
19Cell cycle_Homo sapiens_hsa041101.84306600
20mRNA surveillance pathway_Homo sapiens_hsa030151.83150077
21RNA degradation_Homo sapiens_hsa030181.73365238
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73038684
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61000769
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57062018
25Base excision repair_Homo sapiens_hsa034101.48542879
26Basal transcription factors_Homo sapiens_hsa030221.31821415
27Thyroid cancer_Homo sapiens_hsa052161.26257966
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25742853
29Protein export_Homo sapiens_hsa030601.24830460
30Non-homologous end-joining_Homo sapiens_hsa034501.24525194
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21070977
32Pyruvate metabolism_Homo sapiens_hsa006201.18948059
33Nucleotide excision repair_Homo sapiens_hsa034201.17168762
34p53 signaling pathway_Homo sapiens_hsa041151.17050019
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14484647
36Selenocompound metabolism_Homo sapiens_hsa004501.11214573
37mTOR signaling pathway_Homo sapiens_hsa041501.08601772
38Parkinsons disease_Homo sapiens_hsa050121.07786947
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06132961
40Pyrimidine metabolism_Homo sapiens_hsa002401.06114791
41Huntingtons disease_Homo sapiens_hsa050161.03585564
42Carbon metabolism_Homo sapiens_hsa012001.00570553
43Oxidative phosphorylation_Homo sapiens_hsa001900.98153164
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98005020
45Basal cell carcinoma_Homo sapiens_hsa052170.97825807
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96360928
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94704532
48Oocyte meiosis_Homo sapiens_hsa041140.94554254
49MicroRNAs in cancer_Homo sapiens_hsa052060.92351966
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89428548
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86491226
52Herpes simplex infection_Homo sapiens_hsa051680.84165469
53Ether lipid metabolism_Homo sapiens_hsa005650.80172204
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80136088
55Other glycan degradation_Homo sapiens_hsa005110.77638303
56Pathways in cancer_Homo sapiens_hsa052000.73350423
57N-Glycan biosynthesis_Homo sapiens_hsa005100.73120599
58Glutathione metabolism_Homo sapiens_hsa004800.72727331
59Chemical carcinogenesis_Homo sapiens_hsa052040.72428564
60Hedgehog signaling pathway_Homo sapiens_hsa043400.72222858
61Fatty acid elongation_Homo sapiens_hsa000620.71182291
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70462377
63Inositol phosphate metabolism_Homo sapiens_hsa005620.67204270
64Ovarian steroidogenesis_Homo sapiens_hsa049130.64793736
65Proteasome_Homo sapiens_hsa030500.63588271
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63257373
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.61079277
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.60349365
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.59891100
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57821374
71Pentose phosphate pathway_Homo sapiens_hsa000300.56479705
72Hippo signaling pathway_Homo sapiens_hsa043900.54654495
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53895891
74Acute myeloid leukemia_Homo sapiens_hsa052210.52983627
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51960992
76Steroid biosynthesis_Homo sapiens_hsa001000.51567647
77Wnt signaling pathway_Homo sapiens_hsa043100.51369992
78Primary immunodeficiency_Homo sapiens_hsa053400.50872917
79African trypanosomiasis_Homo sapiens_hsa051430.50807700
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50514368
81Sulfur relay system_Homo sapiens_hsa041220.50432150
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48687123
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47674572
84Choline metabolism in cancer_Homo sapiens_hsa052310.46971643
85Propanoate metabolism_Homo sapiens_hsa006400.46383536
86Folate biosynthesis_Homo sapiens_hsa007900.45776910
87Notch signaling pathway_Homo sapiens_hsa043300.45541261
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.44947198
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.44887681
90Alzheimers disease_Homo sapiens_hsa050100.44660287
91HTLV-I infection_Homo sapiens_hsa051660.42075754
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41586409
93Lysine degradation_Homo sapiens_hsa003100.41447532
94Rap1 signaling pathway_Homo sapiens_hsa040150.41014108
95Viral carcinogenesis_Homo sapiens_hsa052030.40804455
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40517703
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40423893
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.40216563
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40099547
100Apoptosis_Homo sapiens_hsa042100.40012691
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39942406
102Pancreatic cancer_Homo sapiens_hsa052120.38444932
103Chronic myeloid leukemia_Homo sapiens_hsa052200.38201627
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36826849
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.35943352
106Regulation of autophagy_Homo sapiens_hsa041400.35212373
107Non-small cell lung cancer_Homo sapiens_hsa052230.33469014
108Purine metabolism_Homo sapiens_hsa002300.32555267
109Systemic lupus erythematosus_Homo sapiens_hsa053220.32155369
110Hepatitis B_Homo sapiens_hsa051610.31118187
111Small cell lung cancer_Homo sapiens_hsa052220.30933209
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30633022
113TGF-beta signaling pathway_Homo sapiens_hsa043500.30358174
114Shigellosis_Homo sapiens_hsa051310.29877992
115Sulfur metabolism_Homo sapiens_hsa009200.28073425
116Bladder cancer_Homo sapiens_hsa052190.26700785
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24329921
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23817691
119Epstein-Barr virus infection_Homo sapiens_hsa051690.23300311
120Legionellosis_Homo sapiens_hsa051340.22937884
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22850688
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22641135
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21613593
124Prostate cancer_Homo sapiens_hsa052150.21058753
125Colorectal cancer_Homo sapiens_hsa052100.20824318
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20728690
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.20373468
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20338845
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19972041
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19734420
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19570080
132Taste transduction_Homo sapiens_hsa047420.18647843
133Proteoglycans in cancer_Homo sapiens_hsa052050.18374973
134Metabolic pathways_Homo sapiens_hsa011000.18275045
135Adherens junction_Homo sapiens_hsa045200.18158257
136Biosynthesis of amino acids_Homo sapiens_hsa012300.17361249
137Renin-angiotensin system_Homo sapiens_hsa046140.17139363
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.16832205
139Tight junction_Homo sapiens_hsa045300.16707067
140Ras signaling pathway_Homo sapiens_hsa040140.16660468
141Measles_Homo sapiens_hsa051620.13015889
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09444032
143HIF-1 signaling pathway_Homo sapiens_hsa040660.07981749
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.07315712
145Arginine and proline metabolism_Homo sapiens_hsa003300.05730129

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