UTP14C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.43362539
2vascular smooth muscle contraction (GO:0014829)4.12659351
3presynaptic membrane assembly (GO:0097105)3.99880768
4hyperosmotic salinity response (GO:0042538)3.78842429
5negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70530196
6mitotic sister chromatid cohesion (GO:0007064)3.64321560
7ncRNA catabolic process (GO:0034661)3.31800398
8histone mRNA catabolic process (GO:0071044)3.31114853
9intestinal epithelial cell development (GO:0060576)3.25863834
10presynaptic membrane organization (GO:0097090)3.18414247
11nonmotile primary cilium assembly (GO:0035058)3.16826991
12regulation of centriole replication (GO:0046599)3.15599810
13kidney morphogenesis (GO:0060993)3.14584731
14regulation of neuron migration (GO:2001222)3.09719132
15pteridine-containing compound biosynthetic process (GO:0042559)2.96697608
16regulation of meiosis I (GO:0060631)2.96623478
17DNA double-strand break processing (GO:0000729)2.96564911
18inositol phosphate catabolic process (GO:0071545)2.95646920
19piRNA metabolic process (GO:0034587)2.94789634
20apical protein localization (GO:0045176)2.90982385
21negative regulation of translation, ncRNA-mediated (GO:0040033)2.90114933
22regulation of translation, ncRNA-mediated (GO:0045974)2.90114933
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90114933
24limb bud formation (GO:0060174)2.87599629
25microtubule polymerization or depolymerization (GO:0031109)2.75945081
26microtubule anchoring (GO:0034453)2.72632424
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72249430
28gastrulation with mouth forming second (GO:0001702)2.68929427
29regulation of DNA endoreduplication (GO:0032875)2.67869914
30dorsal/ventral axis specification (GO:0009950)2.67424964
31histone H2A acetylation (GO:0043968)2.63354306
32regulation of axon extension involved in axon guidance (GO:0048841)2.61782747
33regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60327804
34regulation of centrosome duplication (GO:0010824)2.60193498
35polyol catabolic process (GO:0046174)2.57598366
36cardiac right ventricle morphogenesis (GO:0003215)2.53950959
37nuclear pore complex assembly (GO:0051292)2.52755462
38hypotonic response (GO:0006971)2.45757790
39L-serine metabolic process (GO:0006563)2.44049406
40negative regulation of neurotransmitter secretion (GO:0046929)2.43096360
41urogenital system development (GO:0001655)2.42765036
42adult feeding behavior (GO:0008343)2.41392318
43hippo signaling (GO:0035329)2.37761707
44positive regulation of glycoprotein biosynthetic process (GO:0010560)2.36409442
45histone-serine phosphorylation (GO:0035404)2.35013110
46photoreceptor cell maintenance (GO:0045494)2.34670531
47DNA replication checkpoint (GO:0000076)2.33863604
48negative regulation of DNA-dependent DNA replication (GO:2000104)2.33671365
49glyoxylate metabolic process (GO:0046487)2.30857487
50positive regulation of glycolytic process (GO:0045821)2.29416430
51pancreas development (GO:0031016)2.27409477
52positive regulation of mitotic sister chromatid separation (GO:1901970)2.27153028
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.27153028
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.27153028
55nuclear pore organization (GO:0006999)2.25310108
56cellular ketone body metabolic process (GO:0046950)2.25002072
57regulation of centrosome cycle (GO:0046605)2.24803711
58negative regulation of fibroblast apoptotic process (GO:2000270)2.24658505
59regulation of response to osmotic stress (GO:0047484)2.24186650
60spinal cord motor neuron differentiation (GO:0021522)2.24017642
61negative regulation of neurotransmitter transport (GO:0051589)2.23597895
62regulation of protein polyubiquitination (GO:1902914)2.23352948
63histone mRNA metabolic process (GO:0008334)2.22983260
64regulation of energy homeostasis (GO:2000505)2.19719762
65monoubiquitinated protein deubiquitination (GO:0035520)2.19567220
66regulation of posttranscriptional gene silencing (GO:0060147)2.19389563
67regulation of gene silencing by miRNA (GO:0060964)2.19389563
68regulation of gene silencing by RNA (GO:0060966)2.19389563
69intra-S DNA damage checkpoint (GO:0031573)2.18420278
70replication fork processing (GO:0031297)2.18151147
71positive regulation of catenin import into nucleus (GO:0035413)2.17885200
72somatic stem cell maintenance (GO:0035019)2.17436310
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.17131679
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.17131679
75regulation of protein glycosylation (GO:0060049)2.16783973
76lateral ventricle development (GO:0021670)2.16690491
77activin receptor signaling pathway (GO:0032924)2.16371736
78negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.15947583
79anterior/posterior axis specification, embryo (GO:0008595)2.15682806
80regulation of axon guidance (GO:1902667)2.14424792
81response to X-ray (GO:0010165)2.13785399
82relaxation of smooth muscle (GO:0044557)2.13313160
83regulation of non-canonical Wnt signaling pathway (GO:2000050)2.12777427
84ketone body metabolic process (GO:1902224)2.12662972
85negative regulation of DNA recombination (GO:0045910)2.12555411
86sister chromatid cohesion (GO:0007062)2.11816556
87neuron recognition (GO:0008038)2.11502399
88double-strand break repair via nonhomologous end joining (GO:0006303)2.11442140
89non-recombinational repair (GO:0000726)2.11442140
90regulation of glucokinase activity (GO:0033131)2.11317563
91regulation of hexokinase activity (GO:1903299)2.11317563
92neural tube formation (GO:0001841)2.10910397
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.09963436
94neuron remodeling (GO:0016322)2.08573062
95single strand break repair (GO:0000012)2.06730780
96dendritic spine morphogenesis (GO:0060997)2.06435213
97positive regulation of SMAD protein import into nucleus (GO:0060391)2.06387387
98lysine metabolic process (GO:0006553)2.06266313
99lysine catabolic process (GO:0006554)2.06266313
100meiotic chromosome segregation (GO:0045132)2.05551578

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human4.50726697
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.79689965
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78233449
4GBX2_23144817_ChIP-Seq_PC3_Human2.70710595
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59686044
6IGF1R_20145208_ChIP-Seq_DFB_Human2.46367565
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25131456
8EWS_26573619_Chip-Seq_HEK293_Human2.18028994
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13227632
10FUS_26573619_Chip-Seq_HEK293_Human2.10844477
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09577867
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.09238645
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01162448
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00827820
15P300_19829295_ChIP-Seq_ESCs_Human1.98273115
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.96253481
17TAF15_26573619_Chip-Seq_HEK293_Human1.91128070
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90527412
19MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.87690488
20SMAD4_21799915_ChIP-Seq_A2780_Human1.81111063
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80468468
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75061587
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74653862
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.73322588
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69665177
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66750421
27AR_21909140_ChIP-Seq_LNCAP_Human1.66500292
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62872066
29TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.60493857
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56483535
31ZNF274_21170338_ChIP-Seq_K562_Hela1.55411256
32STAT3_23295773_ChIP-Seq_U87_Human1.52556483
33TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50935468
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46434890
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.45080637
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44158530
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44158530
38E2F7_22180533_ChIP-Seq_HELA_Human1.42349522
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41467250
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40326047
41STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38658836
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37224701
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37168964
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.35854353
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35259507
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.35044959
47FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34993887
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.34967192
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33925900
50AR_25329375_ChIP-Seq_VCAP_Human1.32671875
51TCF4_23295773_ChIP-Seq_U87_Human1.32510758
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32112358
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30395940
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27609277
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27426721
56ELK1_19687146_ChIP-ChIP_HELA_Human1.26376665
57BCAT_22108803_ChIP-Seq_LS180_Human1.25759037
58RUNX2_22187159_ChIP-Seq_PCA_Human1.24583009
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23789805
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23252820
61TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22760788
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.21968472
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20201985
64TP53_16413492_ChIP-PET_HCT116_Human1.19616408
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19401297
66ER_23166858_ChIP-Seq_MCF-7_Human1.18650972
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18055127
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17883925
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15661792
70CBP_20019798_ChIP-Seq_JUKART_Human1.15385843
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15385843
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15324302
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15235630
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13853267
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13853267
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.13620516
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13011782
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10238679
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09592555
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09384249
81HTT_18923047_ChIP-ChIP_STHdh_Human1.09312259
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.08506242
83CDX2_22108803_ChIP-Seq_LS180_Human1.07932300
84VDR_22108803_ChIP-Seq_LS180_Human1.07684930
85P53_22387025_ChIP-Seq_ESCs_Mouse1.06999179
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06531335
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.05892539
88SOX9_26525672_Chip-Seq_HEART_Mouse1.05785906
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05763343
90JUN_21703547_ChIP-Seq_K562_Human1.05548188
91KDM2B_26808549_Chip-Seq_REH_Human1.03852185
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.01839654
93P300_18555785_Chip-Seq_ESCs_Mouse1.01546915
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01421632
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00440729
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99875231
97BRD4_25478319_ChIP-Seq_HGPS_Human0.99372944
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98892451
99TCF4_22108803_ChIP-Seq_LS180_Human0.98121909
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.97346978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry2.88726062
2MP0008057_abnormal_DNA_replication2.79762664
3MP0000569_abnormal_digit_pigmentation2.40822887
4MP0003283_abnormal_digestive_organ2.39126288
5MP0010352_gastrointestinal_tract_polyps2.35621265
6MP0003880_abnormal_central_pattern2.34354959
7MP0001299_abnormal_eye_distance/2.04548887
8MP0003941_abnormal_skin_development2.00848875
9MP0005423_abnormal_somatic_nervous1.89669956
10MP0000462_abnormal_digestive_system1.87518187
11MP0004084_abnormal_cardiac_muscle1.80700749
12MP0003937_abnormal_limbs/digits/tail_de1.71435365
13MP0005174_abnormal_tail_pigmentation1.69775410
14MP0009780_abnormal_chondrocyte_physiolo1.64758815
15MP0009697_abnormal_copulation1.58457162
16MP0003195_calcinosis1.57654405
17MP0002009_preneoplasia1.55667709
18MP0006072_abnormal_retinal_apoptosis1.54197324
19MP0002735_abnormal_chemical_nociception1.53158329
20MP0003868_abnormal_feces_composition1.42659463
21MP0000516_abnormal_urinary_system1.39931966
22MP0005367_renal/urinary_system_phenotyp1.39931966
23MP0002233_abnormal_nose_morphology1.37103734
24MP0003119_abnormal_digestive_system1.34534299
25MP0002938_white_spotting1.34275037
26MP0001984_abnormal_olfaction1.32520183
27MP0006054_spinal_hemorrhage1.30483570
28MP0008438_abnormal_cutaneous_collagen1.29571148
29MP0008877_abnormal_DNA_methylation1.28901657
30MP0003935_abnormal_craniofacial_develop1.27825891
31MP0002734_abnormal_mechanical_nocicepti1.26639928
32MP0001293_anophthalmia1.21931316
33MP0003755_abnormal_palate_morphology1.21759983
34MP0000428_abnormal_craniofacial_morphol1.21466897
35MP0001529_abnormal_vocalization1.18822217
36MP0001188_hyperpigmentation1.17358189
37MP0002102_abnormal_ear_morphology1.15988279
38MP0002084_abnormal_developmental_patter1.14574445
39MP0004133_heterotaxia1.14082002
40MP0003121_genomic_imprinting1.11474952
41MP0010094_abnormal_chromosome_stability1.10716288
42MP0002909_abnormal_adrenal_gland1.09792985
43MP0004272_abnormal_basement_membrane1.09721678
44MP0008058_abnormal_DNA_repair1.09200315
45MP0003122_maternal_imprinting1.07917173
46MP0005171_absent_coat_pigmentation1.06405489
47MP0001177_atelectasis1.06391325
48MP0006276_abnormal_autonomic_nervous1.06342136
49MP0003693_abnormal_embryo_hatching1.06265581
50MP0004270_analgesia1.05862477
51MP0005187_abnormal_penis_morphology1.04904841
52MP0005220_abnormal_exocrine_pancreas1.04759667
53MP0008775_abnormal_heart_ventricle1.04497879
54MP0004957_abnormal_blastocyst_morpholog1.04341463
55MP0009384_cardiac_valve_regurgitation1.04130334
56MP0003183_abnormal_peptide_metabolism1.03868588
57MP0002697_abnormal_eye_size1.02917149
58MP0000432_abnormal_head_morphology1.02254391
59MP0005275_abnormal_skin_tensile1.01436249
60MP0004147_increased_porphyrin_level1.01048458
61MP0009703_decreased_birth_body1.00799991
62MP0003567_abnormal_fetal_cardiomyocyte0.99459530
63MP0002085_abnormal_embryonic_tissue0.98256256
64MP0000537_abnormal_urethra_morphology0.98154588
65MP0005551_abnormal_eye_electrophysiolog0.97583199
66MP0001485_abnormal_pinna_reflex0.97320680
67MP0001324_abnormal_eye_pigmentation0.95709994
68MP0003861_abnormal_nervous_system0.93755834
69MP0000778_abnormal_nervous_system0.90998256
70MP0004215_abnormal_myocardial_fiber0.89399672
71MP0002751_abnormal_autonomic_nervous0.89306476
72MP0000538_abnormal_urinary_bladder0.87971820
73MP0001286_abnormal_eye_development0.85803129
74MP0009250_abnormal_appendicular_skeleto0.84776687
75MP0005253_abnormal_eye_physiology0.83451283
76MP0004036_abnormal_muscle_relaxation0.83242085
77MP0002822_catalepsy0.82496740
78MP0005503_abnormal_tendon_morphology0.81017753
79MP0004043_abnormal_pH_regulation0.80983685
80MP0003385_abnormal_body_wall0.80845079
81MP0000049_abnormal_middle_ear0.80776003
82MP0000015_abnormal_ear_pigmentation0.79967697
83MP0010234_abnormal_vibrissa_follicle0.79128869
84MP0003950_abnormal_plasma_membrane0.78292177
85MP0003011_delayed_dark_adaptation0.78208839
86MP0005248_abnormal_Harderian_gland0.78139705
87MP0004197_abnormal_fetal_growth/weight/0.77178165
88MP0005380_embryogenesis_phenotype0.76439951
89MP0001672_abnormal_embryogenesis/_devel0.76439951
90MP0002177_abnormal_outer_ear0.75967216
91MP0010386_abnormal_urinary_bladder0.75845673
92MP0002116_abnormal_craniofacial_bone0.75027976
93MP0010368_abnormal_lymphatic_system0.74688609
94MP0005391_vision/eye_phenotype0.73730784
95MP0001730_embryonic_growth_arrest0.73677794
96MP0001697_abnormal_embryo_size0.72962395
97MP0003984_embryonic_growth_retardation0.72534940
98MP0003111_abnormal_nucleus_morphology0.71600574
99MP0002876_abnormal_thyroid_physiology0.70839647
100MP0002088_abnormal_embryonic_growth/wei0.70323670

Predicted human phenotypes

RankGene SetZ-score
1Hip dysplasia (HP:0001385)4.20045592
2Hip contracture (HP:0003273)3.70654878
3Carpal bone hypoplasia (HP:0001498)3.56550209
4Spinal muscular atrophy (HP:0007269)3.49386176
5Abnormality of the middle phalanges of the toes (HP:0010183)3.19751580
6Limited hip movement (HP:0008800)3.16177689
7Papillary thyroid carcinoma (HP:0002895)2.80739238
8Fetal akinesia sequence (HP:0001989)2.80457692
9Barrel-shaped chest (HP:0001552)2.79390649
10Methylmalonic acidemia (HP:0002912)2.79329472
11Colon cancer (HP:0003003)2.59495203
12Abnormality of the phalanges of the hallux (HP:0010057)2.55742611
13Hand muscle atrophy (HP:0009130)2.55644801
14Disproportionate short-trunk short stature (HP:0003521)2.53417868
15Aplasia of the musculature (HP:0100854)2.51193946
16Obstructive sleep apnea (HP:0002870)2.50837236
17Midline defect of the nose (HP:0004122)2.46661042
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39527697
19Broad-based gait (HP:0002136)2.35847838
20Homocystinuria (HP:0002156)2.34297509
21Abnormality of homocysteine metabolism (HP:0010919)2.34297509
22Diaphragmatic weakness (HP:0009113)2.33477982
23Abnormal lung lobation (HP:0002101)2.33136104
24Hyperinsulinemic hypoglycemia (HP:0000825)2.32233290
25Volvulus (HP:0002580)2.28288976
26Epiphyseal dysplasia (HP:0002656)2.26404635
27Shawl scrotum (HP:0000049)2.22480973
28Thyroid carcinoma (HP:0002890)2.18100800
29Small hand (HP:0200055)2.17413725
30Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17206451
31Stridor (HP:0010307)2.17168452
32Sleep apnea (HP:0010535)2.16660063
33Spinal cord compression (HP:0002176)2.14039190
34Abnormal vertebral ossification (HP:0100569)2.13524585
35Abnormality of vitamin B metabolism (HP:0004340)2.12252781
36Hypoplasia of the odontoid process (HP:0003311)2.10225402
37Flat acetabular roof (HP:0003180)2.10206563
38Short middle phalanx of finger (HP:0005819)2.10098591
39Abnormal biliary tract morphology (HP:0012440)2.09723280
40Biliary tract neoplasm (HP:0100574)2.07975865
41Knee flexion contracture (HP:0006380)2.07603318
42Hypoplastic labia majora (HP:0000059)2.07258030
43Neoplasm of the adrenal cortex (HP:0100641)2.06419822
44Abnormality of the vitamin B12 metabolism (HP:0004341)2.03984740
45Ectopic kidney (HP:0000086)2.00741373
46Abnormal hair whorl (HP:0010721)2.00452908
47Muscle fiber splitting (HP:0003555)1.99003025
48Abnormality of vitamin metabolism (HP:0100508)1.98620518
49Hypoglycemic seizures (HP:0002173)1.95991661
50Abnormality of the labia majora (HP:0012881)1.95003054
51Lower limb asymmetry (HP:0100559)1.94457458
52Rhabdomyosarcoma (HP:0002859)1.93662371
53Ependymoma (HP:0002888)1.93562790
54Breast carcinoma (HP:0003002)1.92833756
55Abnormality of the labia minora (HP:0012880)1.90466652
56Abnormality of the vocal cords (HP:0008777)1.89369760
57Aqueductal stenosis (HP:0002410)1.86686943
58Astrocytoma (HP:0009592)1.85941026
59Abnormality of the astrocytes (HP:0100707)1.85941026
60Difficulty running (HP:0009046)1.84051643
61Neoplasm of the adrenal gland (HP:0100631)1.83797529
62Abnormality of chromosome stability (HP:0003220)1.81922203
63Hyperventilation (HP:0002883)1.80114459
64Supernumerary spleens (HP:0009799)1.80039729
65Drooling (HP:0002307)1.78641960
66Hypothermia (HP:0002045)1.76484021
67Pheochromocytoma (HP:0002666)1.75342688
68Neoplasm of the small intestine (HP:0100833)1.73239271
69Bifid tongue (HP:0010297)1.72785237
70Tubulointerstitial nephritis (HP:0001970)1.72559426
71Hypoglycemic coma (HP:0001325)1.71933314
72Limb-girdle muscle atrophy (HP:0003797)1.71249636
73Glioma (HP:0009733)1.71166235
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.70212493
75Long foot (HP:0001833)1.69255045
76Pancreatic islet-cell hyperplasia (HP:0004510)1.68930954
77Metatarsus adductus (HP:0001840)1.68558456
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68324876
79Abnormality of methionine metabolism (HP:0010901)1.68071400
80Genital tract atresia (HP:0001827)1.67573346
81Tracheal stenosis (HP:0002777)1.67322690
82Enlarged penis (HP:0000040)1.66961724
83Soft skin (HP:0000977)1.66893493
84Proximal amyotrophy (HP:0007126)1.66496189
85Distal upper limb amyotrophy (HP:0007149)1.65299685
86Upper limb amyotrophy (HP:0009129)1.65299685
87Chromsome breakage (HP:0040012)1.64267805
88Vaginal atresia (HP:0000148)1.63132061
89Exotropia (HP:0000577)1.63106767
90Methylmalonic aciduria (HP:0012120)1.61517004
91Abnormal pancreas size (HP:0012094)1.58689067
92Preaxial foot polydactyly (HP:0001841)1.56215689
93Pancreatic cysts (HP:0001737)1.55820657
94Meckel diverticulum (HP:0002245)1.55784404
95Cortical dysplasia (HP:0002539)1.54574955
96Abnormality of the calf musculature (HP:0001430)1.54190741
97Labial hypoplasia (HP:0000066)1.53908488
98Abnormality of midbrain morphology (HP:0002418)1.53823427
99Molar tooth sign on MRI (HP:0002419)1.53823427
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.53374591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.30481494
2WNK33.48557761
3TNIK3.35520855
4ACVR1B3.04539866
5CASK2.95104339
6PNCK2.74299116
7TTK2.28317254
8EIF2AK32.21183329
9FGFR22.16975968
10MKNK22.03604452
11STK392.02254485
12STK38L2.00230081
13BMPR1B1.94528044
14STK31.78388968
15MARK11.66149599
16CDC71.61523494
17TAF11.61000579
18CAMK1G1.55799910
19NLK1.54181739
20CLK11.53665463
21AKT31.40558663
22PLK31.36440711
23FER1.36237740
24EIF2AK11.35730414
25LATS11.34757941
26MKNK11.32248877
27NUAK11.20409408
28TGFBR11.17701825
29PLK41.16904844
30STK241.16809401
31OXSR11.16146624
32PASK1.11656325
33YES11.10370158
34PLK21.09264026
35WNK41.08291888
36SRPK11.06143543
37MAP3K41.05969479
38WEE10.99735617
39EPHA30.98781412
40BRSK20.98362899
41BRD40.93108726
42DYRK20.90474534
43CAMK1D0.87078341
44TRIM280.86812127
45FGFR30.85870891
46PAK30.84569582
47CDK30.84538336
48PRKCE0.83206728
49NEK20.82416331
50PRKAA20.82162115
51MAP4K20.78736600
52MAP3K100.75686206
53STK110.75425389
54TSSK60.74470811
55PLK10.74158919
56ATM0.74151344
57PHKG20.74144280
58PHKG10.74144280
59ERBB30.69882387
60STK40.68922128
61WNK10.68679660
62PDGFRA0.68271910
63MST40.67531109
64ADRBK20.66294394
65INSRR0.66285734
66SGK20.66261760
67FGFR10.66133326
68MET0.65185951
69LATS20.64123726
70EPHB20.64122738
71GRK10.61982502
72NEK10.61462590
73SGK10.60898973
74CSNK1E0.60794118
75PRKAA10.59970995
76LMTK20.57490722
77PDGFRB0.56259298
78CHEK20.54669888
79MAP3K70.53848270
80MELK0.53622234
81EIF2AK20.53024512
82STK380.51678866
83ERBB20.51242847
84PRKDC0.50134049
85PAK20.49878325
86MAPK130.49521871
87BCR0.49373695
88RPS6KA40.48626013
89NEK90.48188855
90PRKD30.46894110
91ZAK0.46108203
92DMPK0.43743353
93CDK10.40168660
94ALK0.39081956
95CSNK1G10.38920189
96OBSCN0.38919364
97DYRK1A0.38184472
98PBK0.38181652
99CSNK1D0.37451881
100TRPM70.37397671

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.19983535
2Propanoate metabolism_Homo sapiens_hsa006402.43330075
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.20567479
4Protein export_Homo sapiens_hsa030602.19561311
5Non-homologous end-joining_Homo sapiens_hsa034502.13095502
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10864397
7Butanoate metabolism_Homo sapiens_hsa006502.01121903
8Vitamin B6 metabolism_Homo sapiens_hsa007501.91471550
9Dorso-ventral axis formation_Homo sapiens_hsa043201.91454722
10Selenocompound metabolism_Homo sapiens_hsa004501.75770277
11Fanconi anemia pathway_Homo sapiens_hsa034601.65994380
12Basal transcription factors_Homo sapiens_hsa030221.65691427
13One carbon pool by folate_Homo sapiens_hsa006701.54897347
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52822747
15Circadian rhythm_Homo sapiens_hsa047101.50985834
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47069943
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44258302
18TGF-beta signaling pathway_Homo sapiens_hsa043501.44115786
19Mismatch repair_Homo sapiens_hsa034301.39880916
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32489300
21Steroid biosynthesis_Homo sapiens_hsa001001.28346382
22* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27032112
23Vitamin digestion and absorption_Homo sapiens_hsa049771.24436704
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23177057
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20532023
26Retinol metabolism_Homo sapiens_hsa008301.19619255
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19423099
28Caffeine metabolism_Homo sapiens_hsa002321.17869692
29Regulation of autophagy_Homo sapiens_hsa041401.17826383
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15821686
31Fatty acid metabolism_Homo sapiens_hsa012121.15234551
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14908385
33Fatty acid degradation_Homo sapiens_hsa000711.13948215
34ABC transporters_Homo sapiens_hsa020101.13337818
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12064590
36Adherens junction_Homo sapiens_hsa045201.12043766
37RNA degradation_Homo sapiens_hsa030181.10364465
38Nucleotide excision repair_Homo sapiens_hsa034201.09618927
39Lysine degradation_Homo sapiens_hsa003101.09062397
40Tight junction_Homo sapiens_hsa045301.08075260
41Tryptophan metabolism_Homo sapiens_hsa003801.05763676
42RNA transport_Homo sapiens_hsa030131.05737229
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03555072
44ECM-receptor interaction_Homo sapiens_hsa045121.02776192
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02719933
46Basal cell carcinoma_Homo sapiens_hsa052171.02355861
47Hippo signaling pathway_Homo sapiens_hsa043901.01246722
48beta-Alanine metabolism_Homo sapiens_hsa004100.99283044
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96824987
50Hedgehog signaling pathway_Homo sapiens_hsa043400.96610815
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96355211
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96332934
53Protein digestion and absorption_Homo sapiens_hsa049740.95902502
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.91308107
55Cell cycle_Homo sapiens_hsa041100.88969259
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87725233
57Wnt signaling pathway_Homo sapiens_hsa043100.87293946
58Homologous recombination_Homo sapiens_hsa034400.86357458
59Chemical carcinogenesis_Homo sapiens_hsa052040.86085686
60Mineral absorption_Homo sapiens_hsa049780.85000020
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81549485
62N-Glycan biosynthesis_Homo sapiens_hsa005100.81545372
63MicroRNAs in cancer_Homo sapiens_hsa052060.78305530
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78267606
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.76299544
66Peroxisome_Homo sapiens_hsa041460.75365340
67Nicotine addiction_Homo sapiens_hsa050330.74902731
68Insulin secretion_Homo sapiens_hsa049110.74321703
69mRNA surveillance pathway_Homo sapiens_hsa030150.72704457
70Glycerolipid metabolism_Homo sapiens_hsa005610.70951256
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.68889737
72Starch and sucrose metabolism_Homo sapiens_hsa005000.68671146
73Oocyte meiosis_Homo sapiens_hsa041140.67583546
74Histidine metabolism_Homo sapiens_hsa003400.65036115
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63810106
76Fatty acid biosynthesis_Homo sapiens_hsa000610.63488230
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61577620
78PPAR signaling pathway_Homo sapiens_hsa033200.61219268
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59747646
80Pyruvate metabolism_Homo sapiens_hsa006200.58109403
81Nitrogen metabolism_Homo sapiens_hsa009100.55348426
82Glucagon signaling pathway_Homo sapiens_hsa049220.55251331
83Bile secretion_Homo sapiens_hsa049760.54822058
84Axon guidance_Homo sapiens_hsa043600.54172219
85Taste transduction_Homo sapiens_hsa047420.51312776
86RNA polymerase_Homo sapiens_hsa030200.50416728
87Ether lipid metabolism_Homo sapiens_hsa005650.50148347
88Sphingolipid metabolism_Homo sapiens_hsa006000.48300027
89Melanoma_Homo sapiens_hsa052180.48257619
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48018088
91Glutamatergic synapse_Homo sapiens_hsa047240.47865242
92p53 signaling pathway_Homo sapiens_hsa041150.47121680
93Dilated cardiomyopathy_Homo sapiens_hsa054140.46529514
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46515672
95Long-term depression_Homo sapiens_hsa047300.41614219
96Inositol phosphate metabolism_Homo sapiens_hsa005620.41508831
97Thyroid cancer_Homo sapiens_hsa052160.40445648
98Thyroid hormone synthesis_Homo sapiens_hsa049180.40229173
99Linoleic acid metabolism_Homo sapiens_hsa005910.38450774
100Sulfur metabolism_Homo sapiens_hsa009200.37212672

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