ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pre-miRNA processing (GO:0031054)	5.43362539
2	vascular smooth muscle contraction (GO:0014829)	4.12659351
3	presynaptic membrane assembly (GO:0097105)	3.99880768
4	hyperosmotic salinity response (GO:0042538)	3.78842429
5	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.70530196
6	mitotic sister chromatid cohesion (GO:0007064)	3.64321560
7	ncRNA catabolic process (GO:0034661)	3.31800398
8	histone mRNA catabolic process (GO:0071044)	3.31114853
9	intestinal epithelial cell development (GO:0060576)	3.25863834
10	presynaptic membrane organization (GO:0097090)	3.18414247
11	nonmotile primary cilium assembly (GO:0035058)	3.16826991
12	regulation of centriole replication (GO:0046599)	3.15599810
13	kidney morphogenesis (GO:0060993)	3.14584731
14	regulation of neuron migration (GO:2001222)	3.09719132
15	pteridine-containing compound biosynthetic process (GO:0042559)	2.96697608
16	regulation of meiosis I (GO:0060631)	2.96623478
17	DNA double-strand break processing (GO:0000729)	2.96564911
18	inositol phosphate catabolic process (GO:0071545)	2.95646920
19	piRNA metabolic process (GO:0034587)	2.94789634
20	apical protein localization (GO:0045176)	2.90982385
21	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.90114933
22	regulation of translation, ncRNA-mediated (GO:0045974)	2.90114933
23	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.90114933
24	limb bud formation (GO:0060174)	2.87599629
25	microtubule polymerization or depolymerization (GO:0031109)	2.75945081
26	microtubule anchoring (GO:0034453)	2.72632424
27	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.72249430
28	gastrulation with mouth forming second (GO:0001702)	2.68929427
29	regulation of DNA endoreduplication (GO:0032875)	2.67869914
30	dorsal/ventral axis specification (GO:0009950)	2.67424964
31	histone H2A acetylation (GO:0043968)	2.63354306
32	regulation of axon extension involved in axon guidance (GO:0048841)	2.61782747
33	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.60327804
34	regulation of centrosome duplication (GO:0010824)	2.60193498
35	polyol catabolic process (GO:0046174)	2.57598366
36	cardiac right ventricle morphogenesis (GO:0003215)	2.53950959
37	nuclear pore complex assembly (GO:0051292)	2.52755462
38	hypotonic response (GO:0006971)	2.45757790
39	L-serine metabolic process (GO:0006563)	2.44049406
40	negative regulation of neurotransmitter secretion (GO:0046929)	2.43096360
41	urogenital system development (GO:0001655)	2.42765036
42	adult feeding behavior (GO:0008343)	2.41392318
43	hippo signaling (GO:0035329)	2.37761707
44	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.36409442
45	histone-serine phosphorylation (GO:0035404)	2.35013110
46	photoreceptor cell maintenance (GO:0045494)	2.34670531
47	DNA replication checkpoint (GO:0000076)	2.33863604
48	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.33671365
49	glyoxylate metabolic process (GO:0046487)	2.30857487
50	positive regulation of glycolytic process (GO:0045821)	2.29416430
51	pancreas development (GO:0031016)	2.27409477
52	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.27153028
53	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.27153028
54	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.27153028
55	nuclear pore organization (GO:0006999)	2.25310108
56	cellular ketone body metabolic process (GO:0046950)	2.25002072
57	regulation of centrosome cycle (GO:0046605)	2.24803711
58	negative regulation of fibroblast apoptotic process (GO:2000270)	2.24658505
59	regulation of response to osmotic stress (GO:0047484)	2.24186650
60	spinal cord motor neuron differentiation (GO:0021522)	2.24017642
61	negative regulation of neurotransmitter transport (GO:0051589)	2.23597895
62	regulation of protein polyubiquitination (GO:1902914)	2.23352948
63	histone mRNA metabolic process (GO:0008334)	2.22983260
64	regulation of energy homeostasis (GO:2000505)	2.19719762
65	monoubiquitinated protein deubiquitination (GO:0035520)	2.19567220
66	regulation of posttranscriptional gene silencing (GO:0060147)	2.19389563
67	regulation of gene silencing by miRNA (GO:0060964)	2.19389563
68	regulation of gene silencing by RNA (GO:0060966)	2.19389563
69	intra-S DNA damage checkpoint (GO:0031573)	2.18420278
70	replication fork processing (GO:0031297)	2.18151147
71	positive regulation of catenin import into nucleus (GO:0035413)	2.17885200
72	somatic stem cell maintenance (GO:0035019)	2.17436310
73	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.17131679
74	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.17131679
75	regulation of protein glycosylation (GO:0060049)	2.16783973
76	lateral ventricle development (GO:0021670)	2.16690491
77	activin receptor signaling pathway (GO:0032924)	2.16371736
78	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.15947583
79	anterior/posterior axis specification, embryo (GO:0008595)	2.15682806
80	regulation of axon guidance (GO:1902667)	2.14424792
81	response to X-ray (GO:0010165)	2.13785399
82	relaxation of smooth muscle (GO:0044557)	2.13313160
83	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.12777427
84	ketone body metabolic process (GO:1902224)	2.12662972
85	negative regulation of DNA recombination (GO:0045910)	2.12555411
86	sister chromatid cohesion (GO:0007062)	2.11816556
87	neuron recognition (GO:0008038)	2.11502399
88	double-strand break repair via nonhomologous end joining (GO:0006303)	2.11442140
89	non-recombinational repair (GO:0000726)	2.11442140
90	regulation of glucokinase activity (GO:0033131)	2.11317563
91	regulation of hexokinase activity (GO:1903299)	2.11317563
92	neural tube formation (GO:0001841)	2.10910397
93	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.09963436
94	neuron remodeling (GO:0016322)	2.08573062
95	single strand break repair (GO:0000012)	2.06730780
96	dendritic spine morphogenesis (GO:0060997)	2.06435213
97	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.06387387
98	lysine metabolic process (GO:0006553)	2.06266313
99	lysine catabolic process (GO:0006554)	2.06266313
100	meiotic chromosome segregation (GO:0045132)	2.05551578

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.50726697
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.79689965
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78233449
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.70710595
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59686044
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46367565
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25131456
8	EWS_26573619_Chip-Seq_HEK293_Human	2.18028994
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.13227632
10	FUS_26573619_Chip-Seq_HEK293_Human	2.10844477
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09577867
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.09238645
13	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.01162448
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.00827820
15	P300_19829295_ChIP-Seq_ESCs_Human	1.98273115
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.96253481
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.91128070
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.90527412
19	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.87690488
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81111063
21	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80468468
22	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.75061587
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.74653862
24	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.73322588
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.69665177
26	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.66750421
27	AR_21909140_ChIP-Seq_LNCAP_Human	1.66500292
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62872066
29	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.60493857
30	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.56483535
31	ZNF274_21170338_ChIP-Seq_K562_Hela	1.55411256
32	STAT3_23295773_ChIP-Seq_U87_Human	1.52556483
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50935468
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46434890
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45080637
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44158530
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44158530
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.42349522
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41467250
40	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.40326047
41	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.38658836
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.37224701
43	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.37168964
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35854353
45	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.35259507
46	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.35044959
47	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.34993887
48	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.34967192
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33925900
50	AR_25329375_ChIP-Seq_VCAP_Human	1.32671875
51	TCF4_23295773_ChIP-Seq_U87_Human	1.32510758
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32112358
53	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.30395940
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27609277
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27426721
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26376665
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.25759037
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24583009
59	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.23789805
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23252820
61	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.22760788
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21968472
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20201985
64	TP53_16413492_ChIP-PET_HCT116_Human	1.19616408
65	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19401297
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.18650972
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18055127
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17883925
69	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.15661792
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.15385843
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15385843
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15324302
73	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.15235630
74	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.13853267
75	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.13853267
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13620516
77	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13011782
78	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.10238679
79	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.09592555
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09384249
81	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09312259
82	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08506242
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.07932300
84	VDR_22108803_ChIP-Seq_LS180_Human	1.07684930
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06999179
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06531335
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.05892539
88	SOX9_26525672_Chip-Seq_HEART_Mouse	1.05785906
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.05763343
90	JUN_21703547_ChIP-Seq_K562_Human	1.05548188
91	KDM2B_26808549_Chip-Seq_REH_Human	1.03852185
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.01839654
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.01546915
94	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01421632
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00440729
96	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.99875231
97	BRD4_25478319_ChIP-Seq_HGPS_Human	0.99372944
98	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.98892451
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.98121909
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97346978

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	2.88726062
2	MP0008057_abnormal_DNA_replication	2.79762664
3	MP0000569_abnormal_digit_pigmentation	2.40822887
4	MP0003283_abnormal_digestive_organ	2.39126288
5	MP0010352_gastrointestinal_tract_polyps	2.35621265
6	MP0003880_abnormal_central_pattern	2.34354959
7	MP0001299_abnormal_eye_distance/	2.04548887
8	MP0003941_abnormal_skin_development	2.00848875
9	MP0005423_abnormal_somatic_nervous	1.89669956
10	MP0000462_abnormal_digestive_system	1.87518187
11	MP0004084_abnormal_cardiac_muscle	1.80700749
12	MP0003937_abnormal_limbs/digits/tail_de	1.71435365
13	MP0005174_abnormal_tail_pigmentation	1.69775410
14	MP0009780_abnormal_chondrocyte_physiolo	1.64758815
15	MP0009697_abnormal_copulation	1.58457162
16	MP0003195_calcinosis	1.57654405
17	MP0002009_preneoplasia	1.55667709
18	MP0006072_abnormal_retinal_apoptosis	1.54197324
19	MP0002735_abnormal_chemical_nociception	1.53158329
20	MP0003868_abnormal_feces_composition	1.42659463
21	MP0000516_abnormal_urinary_system	1.39931966
22	MP0005367_renal/urinary_system_phenotyp	1.39931966
23	MP0002233_abnormal_nose_morphology	1.37103734
24	MP0003119_abnormal_digestive_system	1.34534299
25	MP0002938_white_spotting	1.34275037
26	MP0001984_abnormal_olfaction	1.32520183
27	MP0006054_spinal_hemorrhage	1.30483570
28	MP0008438_abnormal_cutaneous_collagen	1.29571148
29	MP0008877_abnormal_DNA_methylation	1.28901657
30	MP0003935_abnormal_craniofacial_develop	1.27825891
31	MP0002734_abnormal_mechanical_nocicepti	1.26639928
32	MP0001293_anophthalmia	1.21931316
33	MP0003755_abnormal_palate_morphology	1.21759983
34	MP0000428_abnormal_craniofacial_morphol	1.21466897
35	MP0001529_abnormal_vocalization	1.18822217
36	MP0001188_hyperpigmentation	1.17358189
37	MP0002102_abnormal_ear_morphology	1.15988279
38	MP0002084_abnormal_developmental_patter	1.14574445
39	MP0004133_heterotaxia	1.14082002
40	MP0003121_genomic_imprinting	1.11474952
41	MP0010094_abnormal_chromosome_stability	1.10716288
42	MP0002909_abnormal_adrenal_gland	1.09792985
43	MP0004272_abnormal_basement_membrane	1.09721678
44	MP0008058_abnormal_DNA_repair	1.09200315
45	MP0003122_maternal_imprinting	1.07917173
46	MP0005171_absent_coat_pigmentation	1.06405489
47	MP0001177_atelectasis	1.06391325
48	MP0006276_abnormal_autonomic_nervous	1.06342136
49	MP0003693_abnormal_embryo_hatching	1.06265581
50	MP0004270_analgesia	1.05862477
51	MP0005187_abnormal_penis_morphology	1.04904841
52	MP0005220_abnormal_exocrine_pancreas	1.04759667
53	MP0008775_abnormal_heart_ventricle	1.04497879
54	MP0004957_abnormal_blastocyst_morpholog	1.04341463
55	MP0009384_cardiac_valve_regurgitation	1.04130334
56	MP0003183_abnormal_peptide_metabolism	1.03868588
57	MP0002697_abnormal_eye_size	1.02917149
58	MP0000432_abnormal_head_morphology	1.02254391
59	MP0005275_abnormal_skin_tensile	1.01436249
60	MP0004147_increased_porphyrin_level	1.01048458
61	MP0009703_decreased_birth_body	1.00799991
62	MP0003567_abnormal_fetal_cardiomyocyte	0.99459530
63	MP0002085_abnormal_embryonic_tissue	0.98256256
64	MP0000537_abnormal_urethra_morphology	0.98154588
65	MP0005551_abnormal_eye_electrophysiolog	0.97583199
66	MP0001485_abnormal_pinna_reflex	0.97320680
67	MP0001324_abnormal_eye_pigmentation	0.95709994
68	MP0003861_abnormal_nervous_system	0.93755834
69	MP0000778_abnormal_nervous_system	0.90998256
70	MP0004215_abnormal_myocardial_fiber	0.89399672
71	MP0002751_abnormal_autonomic_nervous	0.89306476
72	MP0000538_abnormal_urinary_bladder	0.87971820
73	MP0001286_abnormal_eye_development	0.85803129
74	MP0009250_abnormal_appendicular_skeleto	0.84776687
75	MP0005253_abnormal_eye_physiology	0.83451283
76	MP0004036_abnormal_muscle_relaxation	0.83242085
77	MP0002822_catalepsy	0.82496740
78	MP0005503_abnormal_tendon_morphology	0.81017753
79	MP0004043_abnormal_pH_regulation	0.80983685
80	MP0003385_abnormal_body_wall	0.80845079
81	MP0000049_abnormal_middle_ear	0.80776003
82	MP0000015_abnormal_ear_pigmentation	0.79967697
83	MP0010234_abnormal_vibrissa_follicle	0.79128869
84	MP0003950_abnormal_plasma_membrane	0.78292177
85	MP0003011_delayed_dark_adaptation	0.78208839
86	MP0005248_abnormal_Harderian_gland	0.78139705
87	MP0004197_abnormal_fetal_growth/weight/	0.77178165
88	MP0005380_embryogenesis_phenotype	0.76439951
89	MP0001672_abnormal_embryogenesis/_devel	0.76439951
90	MP0002177_abnormal_outer_ear	0.75967216
91	MP0010386_abnormal_urinary_bladder	0.75845673
92	MP0002116_abnormal_craniofacial_bone	0.75027976
93	MP0010368_abnormal_lymphatic_system	0.74688609
94	MP0005391_vision/eye_phenotype	0.73730784
95	MP0001730_embryonic_growth_arrest	0.73677794
96	MP0001697_abnormal_embryo_size	0.72962395
97	MP0003984_embryonic_growth_retardation	0.72534940
98	MP0003111_abnormal_nucleus_morphology	0.71600574
99	MP0002876_abnormal_thyroid_physiology	0.70839647
100	MP0002088_abnormal_embryonic_growth/wei	0.70323670

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hip dysplasia (HP:0001385)	4.20045592
2	Hip contracture (HP:0003273)	3.70654878
3	Carpal bone hypoplasia (HP:0001498)	3.56550209
4	Spinal muscular atrophy (HP:0007269)	3.49386176
5	Abnormality of the middle phalanges of the toes (HP:0010183)	3.19751580
6	Limited hip movement (HP:0008800)	3.16177689
7	Papillary thyroid carcinoma (HP:0002895)	2.80739238
8	Fetal akinesia sequence (HP:0001989)	2.80457692
9	Barrel-shaped chest (HP:0001552)	2.79390649
10	Methylmalonic acidemia (HP:0002912)	2.79329472
11	Colon cancer (HP:0003003)	2.59495203
12	Abnormality of the phalanges of the hallux (HP:0010057)	2.55742611
13	Hand muscle atrophy (HP:0009130)	2.55644801
14	Disproportionate short-trunk short stature (HP:0003521)	2.53417868
15	Aplasia of the musculature (HP:0100854)	2.51193946
16	Obstructive sleep apnea (HP:0002870)	2.50837236
17	Midline defect of the nose (HP:0004122)	2.46661042
18	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.39527697
19	Broad-based gait (HP:0002136)	2.35847838
20	Homocystinuria (HP:0002156)	2.34297509
21	Abnormality of homocysteine metabolism (HP:0010919)	2.34297509
22	Diaphragmatic weakness (HP:0009113)	2.33477982
23	Abnormal lung lobation (HP:0002101)	2.33136104
24	Hyperinsulinemic hypoglycemia (HP:0000825)	2.32233290
25	Volvulus (HP:0002580)	2.28288976
26	Epiphyseal dysplasia (HP:0002656)	2.26404635
27	Shawl scrotum (HP:0000049)	2.22480973
28	Thyroid carcinoma (HP:0002890)	2.18100800
29	Small hand (HP:0200055)	2.17413725
30	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.17206451
31	Stridor (HP:0010307)	2.17168452
32	Sleep apnea (HP:0010535)	2.16660063
33	Spinal cord compression (HP:0002176)	2.14039190
34	Abnormal vertebral ossification (HP:0100569)	2.13524585
35	Abnormality of vitamin B metabolism (HP:0004340)	2.12252781
36	Hypoplasia of the odontoid process (HP:0003311)	2.10225402
37	Flat acetabular roof (HP:0003180)	2.10206563
38	Short middle phalanx of finger (HP:0005819)	2.10098591
39	Abnormal biliary tract morphology (HP:0012440)	2.09723280
40	Biliary tract neoplasm (HP:0100574)	2.07975865
41	Knee flexion contracture (HP:0006380)	2.07603318
42	Hypoplastic labia majora (HP:0000059)	2.07258030
43	Neoplasm of the adrenal cortex (HP:0100641)	2.06419822
44	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.03984740
45	Ectopic kidney (HP:0000086)	2.00741373
46	Abnormal hair whorl (HP:0010721)	2.00452908
47	Muscle fiber splitting (HP:0003555)	1.99003025
48	Abnormality of vitamin metabolism (HP:0100508)	1.98620518
49	Hypoglycemic seizures (HP:0002173)	1.95991661
50	Abnormality of the labia majora (HP:0012881)	1.95003054
51	Lower limb asymmetry (HP:0100559)	1.94457458
52	Rhabdomyosarcoma (HP:0002859)	1.93662371
53	Ependymoma (HP:0002888)	1.93562790
54	Breast carcinoma (HP:0003002)	1.92833756
55	Abnormality of the labia minora (HP:0012880)	1.90466652
56	Abnormality of the vocal cords (HP:0008777)	1.89369760
57	Aqueductal stenosis (HP:0002410)	1.86686943
58	Astrocytoma (HP:0009592)	1.85941026
59	Abnormality of the astrocytes (HP:0100707)	1.85941026
60	Difficulty running (HP:0009046)	1.84051643
61	Neoplasm of the adrenal gland (HP:0100631)	1.83797529
62	Abnormality of chromosome stability (HP:0003220)	1.81922203
63	Hyperventilation (HP:0002883)	1.80114459
64	Supernumerary spleens (HP:0009799)	1.80039729
65	Drooling (HP:0002307)	1.78641960
66	Hypothermia (HP:0002045)	1.76484021
67	Pheochromocytoma (HP:0002666)	1.75342688
68	Neoplasm of the small intestine (HP:0100833)	1.73239271
69	Bifid tongue (HP:0010297)	1.72785237
70	Tubulointerstitial nephritis (HP:0001970)	1.72559426
71	Hypoglycemic coma (HP:0001325)	1.71933314
72	Limb-girdle muscle atrophy (HP:0003797)	1.71249636
73	Glioma (HP:0009733)	1.71166235
74	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.70212493
75	Long foot (HP:0001833)	1.69255045
76	Pancreatic islet-cell hyperplasia (HP:0004510)	1.68930954
77	Metatarsus adductus (HP:0001840)	1.68558456
78	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.68324876
79	Abnormality of methionine metabolism (HP:0010901)	1.68071400
80	Genital tract atresia (HP:0001827)	1.67573346
81	Tracheal stenosis (HP:0002777)	1.67322690
82	Enlarged penis (HP:0000040)	1.66961724
83	Soft skin (HP:0000977)	1.66893493
84	Proximal amyotrophy (HP:0007126)	1.66496189
85	Distal upper limb amyotrophy (HP:0007149)	1.65299685
86	Upper limb amyotrophy (HP:0009129)	1.65299685
87	Chromsome breakage (HP:0040012)	1.64267805
88	Vaginal atresia (HP:0000148)	1.63132061
89	Exotropia (HP:0000577)	1.63106767
90	Methylmalonic aciduria (HP:0012120)	1.61517004
91	Abnormal pancreas size (HP:0012094)	1.58689067
92	Preaxial foot polydactyly (HP:0001841)	1.56215689
93	Pancreatic cysts (HP:0001737)	1.55820657
94	Meckel diverticulum (HP:0002245)	1.55784404
95	Cortical dysplasia (HP:0002539)	1.54574955
96	Abnormality of the calf musculature (HP:0001430)	1.54190741
97	Labial hypoplasia (HP:0000066)	1.53908488
98	Abnormality of midbrain morphology (HP:0002418)	1.53823427
99	Molar tooth sign on MRI (HP:0002419)	1.53823427
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.53374591

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.30481494
2	WNK3	3.48557761
3	TNIK	3.35520855
4	ACVR1B	3.04539866
5	CASK	2.95104339
6	PNCK	2.74299116
7	TTK	2.28317254
8	EIF2AK3	2.21183329
9	FGFR2	2.16975968
10	MKNK2	2.03604452
11	STK39	2.02254485
12	STK38L	2.00230081
13	BMPR1B	1.94528044
14	STK3	1.78388968
15	MARK1	1.66149599
16	CDC7	1.61523494
17	TAF1	1.61000579
18	CAMK1G	1.55799910
19	NLK	1.54181739
20	CLK1	1.53665463
21	AKT3	1.40558663
22	PLK3	1.36440711
23	FER	1.36237740
24	EIF2AK1	1.35730414
25	LATS1	1.34757941
26	MKNK1	1.32248877
27	NUAK1	1.20409408
28	TGFBR1	1.17701825
29	PLK4	1.16904844
30	STK24	1.16809401
31	OXSR1	1.16146624
32	PASK	1.11656325
33	YES1	1.10370158
34	PLK2	1.09264026
35	WNK4	1.08291888
36	SRPK1	1.06143543
37	MAP3K4	1.05969479
38	WEE1	0.99735617
39	EPHA3	0.98781412
40	BRSK2	0.98362899
41	BRD4	0.93108726
42	DYRK2	0.90474534
43	CAMK1D	0.87078341
44	TRIM28	0.86812127
45	FGFR3	0.85870891
46	PAK3	0.84569582
47	CDK3	0.84538336
48	PRKCE	0.83206728
49	NEK2	0.82416331
50	PRKAA2	0.82162115
51	MAP4K2	0.78736600
52	MAP3K10	0.75686206
53	STK11	0.75425389
54	TSSK6	0.74470811
55	PLK1	0.74158919
56	ATM	0.74151344
57	PHKG2	0.74144280
58	PHKG1	0.74144280
59	ERBB3	0.69882387
60	STK4	0.68922128
61	WNK1	0.68679660
62	PDGFRA	0.68271910
63	MST4	0.67531109
64	ADRBK2	0.66294394
65	INSRR	0.66285734
66	SGK2	0.66261760
67	FGFR1	0.66133326
68	MET	0.65185951
69	LATS2	0.64123726
70	EPHB2	0.64122738
71	GRK1	0.61982502
72	NEK1	0.61462590
73	SGK1	0.60898973
74	CSNK1E	0.60794118
75	PRKAA1	0.59970995
76	LMTK2	0.57490722
77	PDGFRB	0.56259298
78	CHEK2	0.54669888
79	MAP3K7	0.53848270
80	MELK	0.53622234
81	EIF2AK2	0.53024512
82	STK38	0.51678866
83	ERBB2	0.51242847
84	PRKDC	0.50134049
85	PAK2	0.49878325
86	MAPK13	0.49521871
87	BCR	0.49373695
88	RPS6KA4	0.48626013
89	NEK9	0.48188855
90	PRKD3	0.46894110
91	ZAK	0.46108203
92	DMPK	0.43743353
93	CDK1	0.40168660
94	ALK	0.39081956
95	CSNK1G1	0.38920189
96	OBSCN	0.38919364
97	DYRK1A	0.38184472
98	PBK	0.38181652
99	CSNK1D	0.37451881
100	TRPM7	0.37397671

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.19983535
2	Propanoate metabolism_Homo sapiens_hsa00640	2.43330075
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.20567479
4	Protein export_Homo sapiens_hsa03060	2.19561311
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.13095502
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.10864397
7	Butanoate metabolism_Homo sapiens_hsa00650	2.01121903
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.91471550
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.91454722
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.75770277
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65994380
12	Basal transcription factors_Homo sapiens_hsa03022	1.65691427
13	One carbon pool by folate_Homo sapiens_hsa00670	1.54897347
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.52822747
15	Circadian rhythm_Homo sapiens_hsa04710	1.50985834
16	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.47069943
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.44258302
18	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.44115786
19	Mismatch repair_Homo sapiens_hsa03430	1.39880916
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.32489300
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.28346382
22	* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.27032112
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.24436704
24	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.23177057
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.20532023
26	Retinol metabolism_Homo sapiens_hsa00830	1.19619255
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19423099
28	Caffeine metabolism_Homo sapiens_hsa00232	1.17869692
29	Regulation of autophagy_Homo sapiens_hsa04140	1.17826383
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.15821686
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.15234551
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14908385
33	Fatty acid degradation_Homo sapiens_hsa00071	1.13948215
34	ABC transporters_Homo sapiens_hsa02010	1.13337818
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.12064590
36	Adherens junction_Homo sapiens_hsa04520	1.12043766
37	RNA degradation_Homo sapiens_hsa03018	1.10364465
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.09618927
39	Lysine degradation_Homo sapiens_hsa00310	1.09062397
40	Tight junction_Homo sapiens_hsa04530	1.08075260
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.05763676
42	RNA transport_Homo sapiens_hsa03013	1.05737229
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03555072
44	ECM-receptor interaction_Homo sapiens_hsa04512	1.02776192
45	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.02719933
46	Basal cell carcinoma_Homo sapiens_hsa05217	1.02355861
47	Hippo signaling pathway_Homo sapiens_hsa04390	1.01246722
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.99283044
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96824987
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96610815
51	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.96355211
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96332934
53	Protein digestion and absorption_Homo sapiens_hsa04974	0.95902502
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91308107
55	Cell cycle_Homo sapiens_hsa04110	0.88969259
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87725233
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.87293946
58	Homologous recombination_Homo sapiens_hsa03440	0.86357458
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86085686
60	Mineral absorption_Homo sapiens_hsa04978	0.85000020
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81549485
62	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.81545372
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.78305530
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78267606
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76299544
66	Peroxisome_Homo sapiens_hsa04146	0.75365340
67	Nicotine addiction_Homo sapiens_hsa05033	0.74902731
68	Insulin secretion_Homo sapiens_hsa04911	0.74321703
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.72704457
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70951256
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68889737
72	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.68671146
73	Oocyte meiosis_Homo sapiens_hsa04114	0.67583546
74	Histidine metabolism_Homo sapiens_hsa00340	0.65036115
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63810106
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63488230
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61577620
78	PPAR signaling pathway_Homo sapiens_hsa03320	0.61219268
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.59747646
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.58109403
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.55348426
82	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55251331
83	Bile secretion_Homo sapiens_hsa04976	0.54822058
84	Axon guidance_Homo sapiens_hsa04360	0.54172219
85	Taste transduction_Homo sapiens_hsa04742	0.51312776
86	RNA polymerase_Homo sapiens_hsa03020	0.50416728
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.50148347
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48300027
89	Melanoma_Homo sapiens_hsa05218	0.48257619
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48018088
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.47865242
92	p53 signaling pathway_Homo sapiens_hsa04115	0.47121680
93	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.46529514
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46515672
95	Long-term depression_Homo sapiens_hsa04730	0.41614219
96	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.41508831
97	Thyroid cancer_Homo sapiens_hsa05216	0.40445648
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40229173
99	Linoleic acid metabolism_Homo sapiens_hsa00591	0.38450774
100	Sulfur metabolism_Homo sapiens_hsa00920	0.37212672

UTP14C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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