

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 6.70624516 |
| 2 | nuclear pore organization (GO:0006999) | 6.55961574 |
| 3 | pore complex assembly (GO:0046931) | 5.00069538 |
| 4 | DNA unwinding involved in DNA replication (GO:0006268) | 4.82455978 |
| 5 | protein localization to kinetochore (GO:0034501) | 4.78890793 |
| 6 | folic acid-containing compound biosynthetic process (GO:0009396) | 4.68772750 |
| 7 | mitotic nuclear envelope disassembly (GO:0007077) | 4.66639418 |
| 8 | regulation of posttranscriptional gene silencing (GO:0060147) | 4.60536480 |
| 9 | regulation of gene silencing by miRNA (GO:0060964) | 4.60536480 |
| 10 | regulation of gene silencing by RNA (GO:0060966) | 4.60536480 |
| 11 | pre-miRNA processing (GO:0031054) | 4.53421669 |
| 12 | nuclear envelope disassembly (GO:0051081) | 4.39252896 |
| 13 | membrane disassembly (GO:0030397) | 4.39252896 |
| 14 | double-strand break repair via nonhomologous end joining (GO:0006303) | 4.27266328 |
| 15 | non-recombinational repair (GO:0000726) | 4.27266328 |
| 16 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.23808471 |
| 17 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.23808471 |
| 18 | establishment of integrated proviral latency (GO:0075713) | 4.15158801 |
| 19 | mitotic sister chromatid cohesion (GO:0007064) | 4.14965320 |
| 20 | IMP biosynthetic process (GO:0006188) | 4.13896607 |
| 21 | heterochromatin organization (GO:0070828) | 4.12412083 |
| 22 | regulation of translational fidelity (GO:0006450) | 4.07503175 |
| 23 | DNA duplex unwinding (GO:0032508) | 3.98759736 |
| 24 | DNA geometric change (GO:0032392) | 3.97092067 |
| 25 | regulation of histone H3-K9 methylation (GO:0051570) | 3.88901395 |
| 26 | sister chromatid segregation (GO:0000819) | 3.88315677 |
| 27 | protein localization to chromosome, centromeric region (GO:0071459) | 3.85234228 |
| 28 | mitotic sister chromatid segregation (GO:0000070) | 3.82711662 |
| 29 | regulation of translational termination (GO:0006449) | 3.82582192 |
| 30 | regulation of RNA export from nucleus (GO:0046831) | 3.80548762 |
| 31 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.79245045 |
| 32 | DNA replication initiation (GO:0006270) | 3.76490490 |
| 33 | mitotic chromosome condensation (GO:0007076) | 3.76269073 |
| 34 | mitotic metaphase plate congression (GO:0007080) | 3.74837020 |
| 35 | negative regulation of histone methylation (GO:0031061) | 3.73898519 |
| 36 | CENP-A containing nucleosome assembly (GO:0034080) | 3.73752632 |
| 37 | nucleobase biosynthetic process (GO:0046112) | 3.68429151 |
| 38 | regulation of mitotic spindle organization (GO:0060236) | 3.66969558 |
| 39 | regulation of spindle organization (GO:0090224) | 3.65968815 |
| 40 | IMP metabolic process (GO:0046040) | 3.64046157 |
| 41 | chromatin assembly (GO:0031497) | 3.60392382 |
| 42 | protein complex localization (GO:0031503) | 3.59207508 |
| 43 | dosage compensation (GO:0007549) | 3.57170699 |
| 44 | ribosome assembly (GO:0042255) | 3.52789221 |
| 45 | telomere maintenance via recombination (GO:0000722) | 3.49954602 |
| 46 | mitotic recombination (GO:0006312) | 3.48974411 |
| 47 | histone H2A monoubiquitination (GO:0035518) | 3.47348285 |
| 48 | paraxial mesoderm development (GO:0048339) | 3.46566968 |
| 49 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.42727022 |
| 50 | nuclear envelope organization (GO:0006998) | 3.41475741 |
| 51 | negative regulation of DNA repair (GO:0045738) | 3.39029032 |
| 52 | maturation of 5.8S rRNA (GO:0000460) | 3.38992156 |
| 53 | metaphase plate congression (GO:0051310) | 3.38297888 |
| 54 | cellular protein complex localization (GO:0034629) | 3.36230784 |
| 55 | positive regulation of chromosome segregation (GO:0051984) | 3.36036174 |
| 56 | formation of translation preinitiation complex (GO:0001731) | 3.28627959 |
| 57 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.27649738 |
| 58 | regulation of helicase activity (GO:0051095) | 3.26413045 |
| 59 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.25001036 |
| 60 | regulation of sister chromatid cohesion (GO:0007063) | 3.20011990 |
| 61 | regulation of centriole replication (GO:0046599) | 3.19843176 |
| 62 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.19584307 |
| 63 | negative regulation of sister chromatid segregation (GO:0033046) | 3.19584307 |
| 64 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.19584307 |
| 65 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.19584307 |
| 66 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.19584307 |
| 67 | histone exchange (GO:0043486) | 3.16422356 |
| 68 | regulation of centrosome cycle (GO:0046605) | 3.16247422 |
| 69 | kinetochore organization (GO:0051383) | 3.15479001 |
| 70 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.14012987 |
| 71 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.14012987 |
| 72 | regulation of sister chromatid segregation (GO:0033045) | 3.14012987 |
| 73 | DNA topological change (GO:0006265) | 3.12536170 |
| 74 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 3.12116858 |
| 75 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.10371752 |
| 76 | DNA conformation change (GO:0071103) | 3.10244956 |
| 77 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.09230038 |
| 78 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.09230038 |
| 79 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.09230038 |
| 80 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 3.09138771 |
| 81 | response to X-ray (GO:0010165) | 3.06714814 |
| 82 | chromatin assembly or disassembly (GO:0006333) | 3.06259209 |
| 83 | regulation of gene silencing (GO:0060968) | 3.06117048 |
| 84 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.05891971 |
| 85 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.05891971 |
| 86 | mRNA transport (GO:0051028) | 3.04025923 |
| 87 | mitotic spindle assembly checkpoint (GO:0007094) | 3.03588410 |
| 88 | purine nucleobase biosynthetic process (GO:0009113) | 3.02430433 |
| 89 | protein K6-linked ubiquitination (GO:0085020) | 3.01200790 |
| 90 | protein localization to chromosome (GO:0034502) | 2.99621616 |
| 91 | meiotic chromosome segregation (GO:0045132) | 2.96813859 |
| 92 | RNA stabilization (GO:0043489) | 2.96392738 |
| 93 | mRNA stabilization (GO:0048255) | 2.96392738 |
| 94 | telomere maintenance via telomere lengthening (GO:0010833) | 2.96143852 |
| 95 | telomere maintenance (GO:0000723) | 2.95850603 |
| 96 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.95735983 |
| 97 | telomere maintenance via telomerase (GO:0007004) | 2.95327953 |
| 98 | mitochondrial RNA metabolic process (GO:0000959) | 2.95073830 |
| 99 | gene silencing by RNA (GO:0031047) | 2.94614466 |
| 100 | chaperone-mediated protein complex assembly (GO:0051131) | 2.94408377 |
| 101 | ribosome biogenesis (GO:0042254) | 2.94363865 |
| 102 | DNA strand elongation (GO:0022616) | 2.93630893 |
| 103 | regulation of chromosome segregation (GO:0051983) | 2.91930678 |
| 104 | telomere organization (GO:0032200) | 2.91835767 |
| 105 | RNA-dependent DNA replication (GO:0006278) | 2.91346711 |
| 106 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.90795917 |
| 107 | tRNA aminoacylation for protein translation (GO:0006418) | 2.90148533 |
| 108 | establishment of viral latency (GO:0019043) | 2.89896580 |
| 109 | NLS-bearing protein import into nucleus (GO:0006607) | 2.89834173 |
| 110 | maturation of SSU-rRNA (GO:0030490) | 2.89384991 |
| 111 | DNA ligation (GO:0006266) | 2.89136401 |
| 112 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.87842500 |
| 113 | determination of adult lifespan (GO:0008340) | 2.87237154 |
| 114 | DNA replication checkpoint (GO:0000076) | 2.87100448 |
| 115 | establishment of chromosome localization (GO:0051303) | 2.86515592 |
| 116 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.85616264 |
| 117 | regulation of centrosome duplication (GO:0010824) | 2.85520776 |
| 118 | regulation of DNA endoreduplication (GO:0032875) | 2.82834610 |
| 119 | tetrahydrofolate metabolic process (GO:0046653) | 2.82332199 |
| 120 | chromatin remodeling at centromere (GO:0031055) | 2.82149422 |
| 121 | nucleic acid transport (GO:0050657) | 2.79107271 |
| 122 | RNA transport (GO:0050658) | 2.79107271 |
| 123 | establishment of RNA localization (GO:0051236) | 2.79107271 |
| 124 | negative regulation of chromosome segregation (GO:0051985) | 2.78529050 |
| 125 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.78152539 |
| 126 | spindle checkpoint (GO:0031577) | 2.76599543 |
| 127 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.76280493 |
| 128 | DNA replication-independent nucleosome organization (GO:0034724) | 2.76280493 |
| 129 | spindle assembly checkpoint (GO:0071173) | 2.74721358 |
| 130 | establishment of apical/basal cell polarity (GO:0035089) | 2.72704906 |
| 131 | mitotic spindle checkpoint (GO:0071174) | 2.71899682 |
| 132 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.71627149 |
| 133 | histone H4-K12 acetylation (GO:0043983) | 2.71621354 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.04269401 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.85309295 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.76338565 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.38145050 |
| 5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.00242599 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.91055391 |
| 7 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.81392071 |
| 8 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.62920775 |
| 9 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.60062543 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.40817929 |
| 11 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.39953340 |
| 12 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.39595993 |
| 13 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.21866478 |
| 14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.21306495 |
| 15 | MYC_22102868_ChIP-Seq_BL_Human | 2.17373701 |
| 16 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.13925352 |
| 17 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.12952497 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.06995486 |
| 19 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.0356935 |
| 20 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.96345523 |
| 21 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.96345523 |
| 22 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.96345523 |
| 23 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.94840382 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.92602535 |
| 25 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.89919467 |
| 26 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.88407063 |
| 27 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88069112 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.86516025 |
| 29 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.82609529 |
| 30 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.75875480 |
| 31 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.72857722 |
| 32 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.65351431 |
| 33 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.63847572 |
| 34 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.51199938 |
| 35 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.44688800 |
| 36 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.44356024 |
| 37 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.43810826 |
| 38 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.43570238 |
| 39 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.42780855 |
| 40 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.42479984 |
| 41 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.42019006 |
| 42 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.41203325 |
| 43 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.40778191 |
| 44 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.40665425 |
| 45 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.39589366 |
| 46 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.39058793 |
| 47 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38965777 |
| 48 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.37784335 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.33623228 |
| 50 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.32879043 |
| 51 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.32623876 |
| 52 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.31491345 |
| 53 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.30587968 |
| 54 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.29674867 |
| 55 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.29464273 |
| 56 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.28261048 |
| 57 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.26985533 |
| 58 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.26355477 |
| 59 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25489399 |
| 60 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.25373226 |
| 61 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.25324799 |
| 62 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.21117229 |
| 63 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.21068716 |
| 64 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20500669 |
| 65 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.19529898 |
| 66 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.17373670 |
| 67 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.15998384 |
| 68 | * TFEB_21752829_ChIP-Seq_HELA_Human | 1.15466333 |
| 69 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.13844933 |
| 70 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.13698914 |
| 71 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.13604839 |
| 72 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.12484795 |
| 73 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.12253355 |
| 74 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.10788659 |
| 75 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.10003198 |
| 76 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.08227874 |
| 77 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.08112813 |
| 78 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.07886558 |
| 79 | EWS_26573619_Chip-Seq_HEK293_Human | 1.07816139 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.07128790 |
| 81 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.06579716 |
| 82 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05850755 |
| 83 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05827402 |
| 84 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.04004625 |
| 85 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.03747805 |
| 86 | FUS_26573619_Chip-Seq_HEK293_Human | 1.03287762 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02396943 |
| 88 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.02170703 |
| 89 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.01944101 |
| 90 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.00827396 |
| 91 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.00044518 |
| 92 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.99841101 |
| 93 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.99405700 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.99091157 |
| 95 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.97935063 |
| 96 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.96991524 |
| 97 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.96015254 |
| 98 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.95566640 |
| 99 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.94094683 |
| 100 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.93200718 |
| 101 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.92958197 |
| 102 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92902136 |
| 103 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92609324 |
| 104 | ATF3_27146783_Chip-Seq_COLON_Human | 0.91045408 |
| 105 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.90854315 |
| 106 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89823387 |
| 107 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.88500370 |
| 108 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.88217077 |
| 109 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.88206460 |
| 110 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.88094525 |
| 111 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.86936829 |
| 112 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.86878716 |
| 113 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.86238357 |
| 114 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.85961302 |
| 115 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.85726483 |
| 116 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.85476736 |
| 117 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.85423080 |
| 118 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.84361773 |
| 119 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.83599848 |
| 120 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.81701113 |
| 121 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.80809429 |
| 122 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.80143651 |
| 123 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.78952382 |
| 124 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.74647056 |
| 125 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.74276445 |
| 126 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.74053730 |
| 127 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.73491755 |
| 128 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.70871941 |
| 129 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.68169284 |
| 130 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.67826466 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 3.68572205 |
| 2 | MP0010352_gastrointestinal_tract_polyps | 3.60800499 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.51681942 |
| 4 | MP0008057_abnormal_DNA_replication | 3.50770593 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.50423975 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.47295456 |
| 7 | MP0003705_abnormal_hypodermis_morpholog | 3.33736668 |
| 8 | MP0003077_abnormal_cell_cycle | 3.11109628 |
| 9 | MP0010307_abnormal_tumor_latency | 2.55673392 |
| 10 | MP0001730_embryonic_growth_arrest | 2.48346457 |
| 11 | MP0005076_abnormal_cell_differentiation | 2.45831433 |
| 12 | MP0003950_abnormal_plasma_membrane | 2.37545785 |
| 13 | MP0009697_abnormal_copulation | 2.28967040 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.27809983 |
| 15 | MP0003123_paternal_imprinting | 2.22651169 |
| 16 | MP0008007_abnormal_cellular_replicative | 2.13494615 |
| 17 | MP0004197_abnormal_fetal_growth/weight/ | 2.13194350 |
| 18 | MP0008058_abnormal_DNA_repair | 2.12915076 |
| 19 | MP0001672_abnormal_embryogenesis/_devel | 2.06796406 |
| 20 | MP0005380_embryogenesis_phenotype | 2.06796406 |
| 21 | MP0002084_abnormal_developmental_patter | 2.01193812 |
| 22 | MP0008877_abnormal_DNA_methylation | 1.92867573 |
| 23 | MP0003984_embryonic_growth_retardation | 1.90736004 |
| 24 | MP0002086_abnormal_extraembryonic_tissu | 1.89667848 |
| 25 | MP0001697_abnormal_embryo_size | 1.89282360 |
| 26 | MP0002088_abnormal_embryonic_growth/wei | 1.88944744 |
| 27 | MP0008932_abnormal_embryonic_tissue | 1.86780331 |
| 28 | MP0002085_abnormal_embryonic_tissue | 1.83921816 |
| 29 | MP0002009_preneoplasia | 1.81209259 |
| 30 | MP0001661_extended_life_span | 1.79528472 |
| 31 | MP0002396_abnormal_hematopoietic_system | 1.66792333 |
| 32 | MP0010234_abnormal_vibrissa_follicle | 1.65155405 |
| 33 | MP0003566_abnormal_cell_adhesion | 1.64538153 |
| 34 | MP0002080_prenatal_lethality | 1.62652731 |
| 35 | MP0003890_abnormal_embryonic-extraembry | 1.62094002 |
| 36 | MP0003941_abnormal_skin_development | 1.59061177 |
| 37 | MP0003121_genomic_imprinting | 1.53715281 |
| 38 | MP0000537_abnormal_urethra_morphology | 1.44560261 |
| 39 | MP0001293_anophthalmia | 1.43863569 |
| 40 | MP0009053_abnormal_anal_canal | 1.42621271 |
| 41 | MP0003786_premature_aging | 1.40622016 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.39185327 |
| 43 | MP0005623_abnormal_meninges_morphology | 1.36110787 |
| 44 | MP0004272_abnormal_basement_membrane | 1.35920486 |
| 45 | MP0010030_abnormal_orbit_morphology | 1.33399202 |
| 46 | MP0005023_abnormal_wound_healing | 1.33100413 |
| 47 | MP0004808_abnormal_hematopoietic_stem | 1.32367068 |
| 48 | MP0001915_intracranial_hemorrhage | 1.28480209 |
| 49 | MP0003119_abnormal_digestive_system | 1.25839286 |
| 50 | MP0000490_abnormal_crypts_of | 1.23867135 |
| 51 | MP0004264_abnormal_extraembryonic_tissu | 1.23433363 |
| 52 | MP0000733_abnormal_muscle_development | 1.21593022 |
| 53 | MP0002697_abnormal_eye_size | 1.20253583 |
| 54 | MP0000428_abnormal_craniofacial_morphol | 1.16647793 |
| 55 | MP0003937_abnormal_limbs/digits/tail_de | 1.13947442 |
| 56 | MP0000313_abnormal_cell_death | 1.12584697 |
| 57 | MP0003806_abnormal_nucleotide_metabolis | 1.11965782 |
| 58 | MP0009703_decreased_birth_body | 1.09667120 |
| 59 | MP0000358_abnormal_cell_content/ | 1.08520414 |
| 60 | MP0002019_abnormal_tumor_incidence | 1.08393932 |
| 61 | MP0001849_ear_inflammation | 1.07688797 |
| 62 | MP0002092_abnormal_eye_morphology | 1.07108221 |
| 63 | MP0009672_abnormal_birth_weight | 1.06638691 |
| 64 | MP0002111_abnormal_tail_morphology | 1.03011683 |
| 65 | MP0008438_abnormal_cutaneous_collagen | 1.02597778 |
| 66 | MP0006035_abnormal_mitochondrial_morpho | 1.02223111 |
| 67 | MP0002925_abnormal_cardiovascular_devel | 0.99807483 |
| 68 | MP0003115_abnormal_respiratory_system | 0.99453355 |
| 69 | MP0002254_reproductive_system_inflammat | 0.99212743 |
| 70 | MP0004133_heterotaxia | 0.98872882 |
| 71 | MP0000432_abnormal_head_morphology | 0.98412056 |
| 72 | MP0003943_abnormal_hepatobiliary_system | 0.97315195 |
| 73 | MP0003091_abnormal_cell_migration | 0.93783088 |
| 74 | MP0003935_abnormal_craniofacial_develop | 0.92350273 |
| 75 | MP0002006_tumorigenesis | 0.91782309 |
| 76 | MP0002796_impaired_skin_barrier | 0.91634055 |
| 77 | MP0002210_abnormal_sex_determination | 0.91617414 |
| 78 | MP0003300_gastrointestinal_ulcer | 0.91612360 |
| 79 | MP0010678_abnormal_skin_adnexa | 0.91414584 |
| 80 | MP0002060_abnormal_skin_morphology | 0.88414814 |
| 81 | MP0004185_abnormal_adipocyte_glucose | 0.88178243 |
| 82 | MP0000579_abnormal_nail_morphology | 0.87263267 |
| 83 | MP0005621_abnormal_cell_physiology | 0.86490642 |
| 84 | MP0002877_abnormal_melanocyte_morpholog | 0.84949481 |
| 85 | MP0001145_abnormal_male_reproductive | 0.83801337 |
| 86 | MP0003279_aneurysm | 0.83102132 |
| 87 | MP0001299_abnormal_eye_distance/ | 0.82467524 |
| 88 | MP0009278_abnormal_bone_marrow | 0.82127776 |
| 89 | MP0003221_abnormal_cardiomyocyte_apopto | 0.80724946 |
| 90 | MP0000569_abnormal_digit_pigmentation | 0.79505526 |
| 91 | MP0005384_cellular_phenotype | 0.78066440 |
| 92 | MP0001286_abnormal_eye_development | 0.77362519 |
| 93 | MP0002233_abnormal_nose_morphology | 0.76693714 |
| 94 | MP0006292_abnormal_olfactory_placode | 0.75871622 |
| 95 | MP0008770_decreased_survivor_rate | 0.75382775 |
| 96 | MP0000703_abnormal_thymus_morphology | 0.74470408 |
| 97 | MP0005408_hypopigmentation | 0.74228641 |
| 98 | MP0003315_abnormal_perineum_morphology | 0.74150447 |
| 99 | MP0003718_maternal_effect | 0.72047459 |
| 100 | MP0000477_abnormal_intestine_morphology | 0.71289157 |
| 101 | MP0004233_abnormal_muscle_weight | 0.71196524 |
| 102 | MP0000383_abnormal_hair_follicle | 0.69750714 |
| 103 | MP0000762_abnormal_tongue_morphology | 0.69221850 |
| 104 | MP0000266_abnormal_heart_morphology | 0.68034397 |
| 105 | MP0002653_abnormal_ependyma_morphology | 0.68027201 |
| 106 | MP0005395_other_phenotype | 0.67645305 |
| 107 | MP0003385_abnormal_body_wall | 0.67629778 |
| 108 | MP0003861_abnormal_nervous_system | 0.67445931 |
| 109 | MP0000653_abnormal_sex_gland | 0.67144803 |
| 110 | MP0003755_abnormal_palate_morphology | 0.67025408 |
| 111 | MP0002160_abnormal_reproductive_system | 0.66963938 |
| 112 | MP0003453_abnormal_keratinocyte_physiol | 0.66162535 |
| 113 | MP0005501_abnormal_skin_physiology | 0.65261187 |
| 114 | MP0001929_abnormal_gametogenesis | 0.64346544 |
| 115 | MP0002166_altered_tumor_susceptibility | 0.63871754 |
| 116 | MP0001545_abnormal_hematopoietic_system | 0.62766408 |
| 117 | MP0005397_hematopoietic_system_phenotyp | 0.62766408 |
| 118 | MP0002269_muscular_atrophy | 0.62396252 |
| 119 | MP0000427_abnormal_hair_cycle | 0.61958218 |
| 120 | MP0001346_abnormal_lacrimal_gland | 0.61796739 |
| 121 | MP0002932_abnormal_joint_morphology | 0.61669047 |
| 122 | MP0003936_abnormal_reproductive_system | 0.61193063 |
| 123 | MP0000627_abnormal_mammary_gland | 0.60874903 |
| 124 | MP0005275_abnormal_skin_tensile | 0.60719844 |
| 125 | MP0001216_abnormal_epidermal_layer | 0.60204373 |
| 126 | MP0001243_abnormal_dermal_layer | 0.60081229 |
| 127 | MP0000516_abnormal_urinary_system | 0.59962401 |
| 128 | MP0005367_renal/urinary_system_phenotyp | 0.59962401 |
| 129 | MP0002938_white_spotting | 0.59737745 |
| 130 | MP0003448_altered_tumor_morphology | 0.59270414 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ependymoma (HP:0002888) | 4.17070077 |
| 2 | Neoplasm of the oral cavity (HP:0100649) | 3.45891312 |
| 3 | Nephroblastoma (Wilms tumor) (HP:0002667) | 3.44603450 |
| 4 | Abnormality of the astrocytes (HP:0100707) | 3.35546999 |
| 5 | Astrocytoma (HP:0009592) | 3.35546999 |
| 6 | Medulloblastoma (HP:0002885) | 3.34528475 |
| 7 | Embryonal renal neoplasm (HP:0011794) | 3.28070367 |
| 8 | Selective tooth agenesis (HP:0001592) | 3.23048978 |
| 9 | Protrusio acetabuli (HP:0003179) | 3.14966235 |
| 10 | Chromsome breakage (HP:0040012) | 3.01294752 |
| 11 | Rhabdomyosarcoma (HP:0002859) | 3.00803322 |
| 12 | Abnormality of the labia minora (HP:0012880) | 2.99665600 |
| 13 | Deviation of the thumb (HP:0009603) | 2.97423954 |
| 14 | Multiple enchondromatosis (HP:0005701) | 2.93154771 |
| 15 | Proximal placement of thumb (HP:0009623) | 2.84811174 |
| 16 | Glioma (HP:0009733) | 2.74692344 |
| 17 | Skull defect (HP:0001362) | 2.73980469 |
| 18 | Colon cancer (HP:0003003) | 2.73881509 |
| 19 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.72226154 |
| 20 | Volvulus (HP:0002580) | 2.68685170 |
| 21 | High pitched voice (HP:0001620) | 2.66449192 |
| 22 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.63397077 |
| 23 | Short 4th metacarpal (HP:0010044) | 2.63397077 |
| 24 | Wrist flexion contracture (HP:0001239) | 2.63228129 |
| 25 | Neoplasm of striated muscle (HP:0009728) | 2.59813803 |
| 26 | Abnormality of the carotid arteries (HP:0005344) | 2.56771738 |
| 27 | Agnosia (HP:0010524) | 2.52195517 |
| 28 | Duplicated collecting system (HP:0000081) | 2.49739813 |
| 29 | Biliary tract neoplasm (HP:0100574) | 2.49071437 |
| 30 | Long eyelashes (HP:0000527) | 2.47525091 |
| 31 | Abnormality of chromosome stability (HP:0003220) | 2.41000403 |
| 32 | Basal cell carcinoma (HP:0002671) | 2.40844068 |
| 33 | Missing ribs (HP:0000921) | 2.37893069 |
| 34 | Cerebral aneurysm (HP:0004944) | 2.34852890 |
| 35 | Increased nuchal translucency (HP:0010880) | 2.29933678 |
| 36 | Abnormality of the duodenum (HP:0002246) | 2.29560087 |
| 37 | Abnormality of the pons (HP:0007361) | 2.29545273 |
| 38 | Prominent nose (HP:0000448) | 2.28596703 |
| 39 | Birth length less than 3rd percentile (HP:0003561) | 2.28358762 |
| 40 | Ulnar bowing (HP:0003031) | 2.27890558 |
| 41 | Microvesicular hepatic steatosis (HP:0001414) | 2.22496697 |
| 42 | Short humerus (HP:0005792) | 2.22428009 |
| 43 | Impulsivity (HP:0100710) | 2.21559352 |
| 44 | Shallow orbits (HP:0000586) | 2.21277972 |
| 45 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.20494774 |
| 46 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.20337465 |
| 47 | Gastrointestinal carcinoma (HP:0002672) | 2.20337465 |
| 48 | Ectopic kidney (HP:0000086) | 2.19931810 |
| 49 | Sloping forehead (HP:0000340) | 2.18955417 |
| 50 | Clubbing of toes (HP:0100760) | 2.18478985 |
| 51 | Progressive muscle weakness (HP:0003323) | 2.17821433 |
| 52 | Abnormal lung lobation (HP:0002101) | 2.17428584 |
| 53 | Vertebral clefting (HP:0008428) | 2.13908140 |
| 54 | Pseudobulbar signs (HP:0002200) | 2.12589999 |
| 55 | Ankle contracture (HP:0006466) | 2.12239777 |
| 56 | Choanal atresia (HP:0000453) | 2.12153447 |
| 57 | Cortical dysplasia (HP:0002539) | 2.10621611 |
| 58 | Trismus (HP:0000211) | 2.08300157 |
| 59 | Short 1st metacarpal (HP:0010034) | 2.08263404 |
| 60 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 2.08263404 |
| 61 | Absent radius (HP:0003974) | 2.07535383 |
| 62 | Progressive external ophthalmoplegia (HP:0000590) | 2.07282032 |
| 63 | Sandal gap (HP:0001852) | 2.05082881 |
| 64 | Abnormal number of incisors (HP:0011064) | 2.02211303 |
| 65 | Reticulocytopenia (HP:0001896) | 2.00989422 |
| 66 | Acute myeloid leukemia (HP:0004808) | 2.00708286 |
| 67 | Cafe-au-lait spot (HP:0000957) | 1.99161807 |
| 68 | Amaurosis fugax (HP:0100576) | 1.98633926 |
| 69 | Overlapping toe (HP:0001845) | 1.97955098 |
| 70 | Heterotopia (HP:0002282) | 1.96974879 |
| 71 | Low anterior hairline (HP:0000294) | 1.96306952 |
| 72 | Abnormality of the renal collecting system (HP:0004742) | 1.94871558 |
| 73 | Insidious onset (HP:0003587) | 1.92185286 |
| 74 | Termporal pattern (HP:0011008) | 1.92185286 |
| 75 | Meckel diverticulum (HP:0002245) | 1.91836588 |
| 76 | Facial cleft (HP:0002006) | 1.91525662 |
| 77 | Facial hemangioma (HP:0000329) | 1.91164735 |
| 78 | Absent forearm bone (HP:0003953) | 1.91040609 |
| 79 | Aplasia involving forearm bones (HP:0009822) | 1.91040609 |
| 80 | 11 pairs of ribs (HP:0000878) | 1.89901792 |
| 81 | Ureteral duplication (HP:0000073) | 1.89897854 |
| 82 | Radial bowing (HP:0002986) | 1.89581343 |
| 83 | Urethral obstruction (HP:0000796) | 1.89535617 |
| 84 | Supernumerary ribs (HP:0005815) | 1.88923087 |
| 85 | Rib fusion (HP:0000902) | 1.88055730 |
| 86 | Short phalanx of the thumb (HP:0009660) | 1.87064538 |
| 87 | Patellar aplasia (HP:0006443) | 1.85070682 |
| 88 | Neoplasm of the colon (HP:0100273) | 1.84961507 |
| 89 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.84941607 |
| 90 | Abnormality of the 4th metacarpal (HP:0010012) | 1.84235417 |
| 91 | Neoplasm of the pancreas (HP:0002894) | 1.83318392 |
| 92 | Increased density of long bones (HP:0006392) | 1.82828438 |
| 93 | Abnormality of the lower motor neuron (HP:0002366) | 1.82510500 |
| 94 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.82103543 |
| 95 | Abnormality of the ileum (HP:0001549) | 1.82083787 |
| 96 | Atresia of the external auditory canal (HP:0000413) | 1.81761053 |
| 97 | Asymmetry of the thorax (HP:0001555) | 1.81167470 |
| 98 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.80831464 |
| 99 | Hypopigmentation of the fundus (HP:0007894) | 1.80402520 |
| 100 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.79996789 |
| 101 | Abnormality of the calcaneus (HP:0008364) | 1.79424042 |
| 102 | Spastic diplegia (HP:0001264) | 1.78365663 |
| 103 | Abnormality of the anterior horn cell (HP:0006802) | 1.77789200 |
| 104 | Degeneration of anterior horn cells (HP:0002398) | 1.77789200 |
| 105 | Embryonal neoplasm (HP:0002898) | 1.76850310 |
| 106 | Myelodysplasia (HP:0002863) | 1.75414104 |
| 107 | Abnormality of the 1st metacarpal (HP:0010009) | 1.75378738 |
| 108 | Broad thumb (HP:0011304) | 1.75312072 |
| 109 | Neoplasm of the adrenal cortex (HP:0100641) | 1.75250586 |
| 110 | Arteriovenous malformation (HP:0100026) | 1.74748418 |
| 111 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.74438633 |
| 112 | Abnormal foot bone ossification (HP:0010675) | 1.74152578 |
| 113 | Abnormality of the preputium (HP:0100587) | 1.74011056 |
| 114 | Partial agenesis of the corpus callosum (HP:0001338) | 1.73923261 |
| 115 | Absent thumb (HP:0009777) | 1.73308798 |
| 116 | Breast hypoplasia (HP:0003187) | 1.72963862 |
| 117 | Abdominal situs inversus (HP:0003363) | 1.72308760 |
| 118 | Abnormality of abdominal situs (HP:0011620) | 1.72308760 |
| 119 | Abnormal vertebral ossification (HP:0100569) | 1.72046332 |
| 120 | Small intestinal stenosis (HP:0012848) | 1.70378084 |
| 121 | Duodenal stenosis (HP:0100867) | 1.70378084 |
| 122 | Horseshoe kidney (HP:0000085) | 1.70118190 |
| 123 | Skin tags (HP:0010609) | 1.69105076 |
| 124 | Abnormality of the peritoneum (HP:0002585) | 1.69091645 |
| 125 | Dysmetric saccades (HP:0000641) | 1.68248793 |
| 126 | Supernumerary spleens (HP:0009799) | 1.68183191 |
| 127 | Genu recurvatum (HP:0002816) | 1.68051383 |
| 128 | Esophageal atresia (HP:0002032) | 1.67990446 |
| 129 | Squamous cell carcinoma (HP:0002860) | 1.67909872 |
| 130 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.67640192 |
| 131 | Deep philtrum (HP:0002002) | 1.66489214 |
| 132 | Postnatal microcephaly (HP:0005484) | 1.65797152 |
| 133 | Broad palm (HP:0001169) | 1.65468823 |
| 134 | Microglossia (HP:0000171) | 1.64916943 |
| 135 | Abnormality of methionine metabolism (HP:0010901) | 1.63675771 |
| 136 | Hypoplasia of the pons (HP:0012110) | 1.63157451 |
| 137 | High anterior hairline (HP:0009890) | 1.62918609 |
| 138 | Premature ovarian failure (HP:0008209) | 1.62029708 |
| 139 | Uterine neoplasm (HP:0010784) | 1.60865878 |
| 140 | Secondary amenorrhea (HP:0000869) | 1.60549349 |
| 141 | Triphalangeal thumb (HP:0001199) | 1.59110518 |
| 142 | Neoplasm of the small intestine (HP:0100833) | 1.58443730 |
| 143 | Breast carcinoma (HP:0003002) | 1.58255813 |
| 144 | Short thumb (HP:0009778) | 1.57259112 |
| 145 | Neuroblastoma (HP:0003006) | 1.56471587 |
| 146 | Primitive neuroectodermal tumor (HP:0030065) | 1.56471587 |
| 147 | Neuroblastic tumors (HP:0004376) | 1.56471587 |
| 148 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 1.56471587 |
| 149 | Abnormality of the umbilical cord (HP:0010881) | 1.55902759 |
| 150 | Neuroectodermal neoplasm (HP:0030061) | 1.55714320 |
| 151 | Neuroepithelial neoplasm (HP:0030063) | 1.55714320 |
| 152 | Nervous tissue neoplasm (HP:0030060) | 1.55714320 |
| 153 | Uterine leiomyosarcoma (HP:0002891) | 1.54662978 |
| 154 | Leiomyosarcoma (HP:0100243) | 1.54662978 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 5.23369521 |
| 2 | CDC7 | 3.95378557 |
| 3 | SCYL2 | 2.96227493 |
| 4 | PBK | 2.90731445 |
| 5 | EEF2K | 2.85678506 |
| 6 | EPHA2 | 2.73194580 |
| 7 | NEK2 | 2.71022825 |
| 8 | WEE1 | 2.65545580 |
| 9 | TTK | 2.40705293 |
| 10 | BRD4 | 2.13093928 |
| 11 | PKN2 | 2.09484626 |
| 12 | TSSK6 | 2.05030961 |
| 13 | RPS6KB2 | 2.01803813 |
| 14 | LATS1 | 1.99544275 |
| 15 | TAF1 | 1.95664517 |
| 16 | NEK1 | 1.84650645 |
| 17 | MAP3K10 | 1.82067407 |
| 18 | SMG1 | 1.79694198 |
| 19 | BUB1 | 1.78034472 |
| 20 | SRPK1 | 1.71149521 |
| 21 | CDK7 | 1.62574934 |
| 22 | TTN | 1.60252614 |
| 23 | CDK4 | 1.60165737 |
| 24 | ATR | 1.59645665 |
| 25 | PASK | 1.59579665 |
| 26 | STK10 | 1.58179328 |
| 27 | PLK1 | 1.56713758 |
| 28 | ALK | 1.53932838 |
| 29 | CHEK1 | 1.49752495 |
| 30 | ACVR1B | 1.43405705 |
| 31 | AURKB | 1.40999313 |
| 32 | MAP3K8 | 1.40320819 |
| 33 | MTOR | 1.39103267 |
| 34 | VRK2 | 1.34871425 |
| 35 | MST1R | 1.33538598 |
| 36 | CHEK2 | 1.31905775 |
| 37 | CDK6 | 1.29364521 |
| 38 | PLK3 | 1.26265115 |
| 39 | MST4 | 1.25650102 |
| 40 | MKNK1 | 1.25187660 |
| 41 | STK3 | 1.21655648 |
| 42 | PAK4 | 1.20525034 |
| 43 | TGFBR1 | 1.20176281 |
| 44 | ATM | 1.16432821 |
| 45 | EIF2AK2 | 1.14726147 |
| 46 | NUAK1 | 1.11708435 |
| 47 | TLK1 | 1.11647624 |
| 48 | RPS6KA4 | 1.09082274 |
| 49 | EIF2AK1 | 1.08294925 |
| 50 | MKNK2 | 1.05184786 |
| 51 | BRSK2 | 1.04252845 |
| 52 | VRK1 | 1.02200128 |
| 53 | CDK2 | 0.99753284 |
| 54 | TRIB3 | 0.99648131 |
| 55 | FLT3 | 0.97828339 |
| 56 | STK4 | 0.97059528 |
| 57 | LATS2 | 0.96170491 |
| 58 | PAK2 | 0.92812192 |
| 59 | PNCK | 0.91715506 |
| 60 | PIM1 | 0.91253722 |
| 61 | FGFR1 | 0.90298684 |
| 62 | PDGFRA | 0.88515332 |
| 63 | BRSK1 | 0.85985801 |
| 64 | TRIM28 | 0.84537608 |
| 65 | PTK6 | 0.84302976 |
| 66 | PLK4 | 0.83348012 |
| 67 | NME2 | 0.81713180 |
| 68 | CAMK1D | 0.80047671 |
| 69 | MELK | 0.78038891 |
| 70 | RIPK1 | 0.77560414 |
| 71 | MET | 0.76949671 |
| 72 | BMX | 0.76377273 |
| 73 | CSNK1D | 0.73517233 |
| 74 | LRRK2 | 0.73101169 |
| 75 | ICK | 0.73015732 |
| 76 | TESK2 | 0.72915693 |
| 77 | CDK1 | 0.72034261 |
| 78 | CDK9 | 0.70956121 |
| 79 | AURKA | 0.70195904 |
| 80 | MAP2K3 | 0.69403843 |
| 81 | ZAK | 0.68771316 |
| 82 | CSNK1E | 0.66186286 |
| 83 | STK38L | 0.65865284 |
| 84 | PDK2 | 0.62654881 |
| 85 | PRKDC | 0.58825338 |
| 86 | CLK1 | 0.56767546 |
| 87 | CSNK2A2 | 0.55790077 |
| 88 | CDK8 | 0.54553974 |
| 89 | TRPM7 | 0.53099663 |
| 90 | DYRK3 | 0.53018454 |
| 91 | MAP4K1 | 0.52914376 |
| 92 | STK39 | 0.51352169 |
| 93 | BMPR1B | 0.48954024 |
| 94 | CSNK1G1 | 0.48755223 |
| 95 | AKT2 | 0.47757246 |
| 96 | NEK9 | 0.47024715 |
| 97 | MAPK14 | 0.46323654 |
| 98 | YES1 | 0.44941794 |
| 99 | CHUK | 0.44376698 |
| 100 | NLK | 0.41605820 |
| 101 | MAPK1 | 0.40981329 |
| 102 | TYRO3 | 0.40078113 |
| 103 | DDR2 | 0.39632879 |
| 104 | PAK1 | 0.39598540 |
| 105 | MAPKAPK5 | 0.39423587 |
| 106 | NME1 | 0.39382109 |
| 107 | PDGFRB | 0.38602298 |
| 108 | ERBB3 | 0.38411837 |
| 109 | ERBB4 | 0.38132494 |
| 110 | MAP3K3 | 0.38050740 |
| 111 | PTK2 | 0.37072372 |
| 112 | AKT1 | 0.34602105 |
| 113 | PRKCI | 0.34321002 |
| 114 | GSK3B | 0.34195686 |
| 115 | NEK6 | 0.32246568 |
| 116 | RPS6KB1 | 0.30089797 |
| 117 | PDK3 | 0.29712359 |
| 118 | PDK4 | 0.29712359 |
| 119 | SIK2 | 0.28979824 |
| 120 | EIF2AK3 | 0.28511909 |
| 121 | RPS6KA5 | 0.27814584 |
| 122 | CDK3 | 0.27703005 |
| 123 | AKT3 | 0.27462947 |
| 124 | CSNK2A1 | 0.26693158 |
| 125 | FGFR3 | 0.25545829 |
| 126 | CAMK1G | 0.25346713 |
| 127 | RPS6KA1 | 0.23745441 |
| 128 | MAPK10 | 0.23685236 |
| 129 | JAK3 | 0.23607820 |
| 130 | PLK2 | 0.22857598 |
| 131 | CSNK1A1L | 0.22638023 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.92536095 |
| 2 | One carbon pool by folate_Homo sapiens_hsa00670 | 3.64742263 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.58343516 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.39148987 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.35181405 |
| 6 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.95532060 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.84351449 |
| 8 | Cell cycle_Homo sapiens_hsa04110 | 2.73194337 |
| 9 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.28458507 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.16987701 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.04538741 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.02621712 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.00449954 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.94477379 |
| 15 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.85776697 |
| 16 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.81037124 |
| 17 | RNA polymerase_Homo sapiens_hsa03020 | 1.67593789 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.67376750 |
| 19 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.52708359 |
| 20 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.52034189 |
| 21 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.51556626 |
| 22 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.48568710 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.48096493 |
| 24 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.44655567 |
| 25 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.44025820 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.30247224 |
| 27 | Lysine degradation_Homo sapiens_hsa00310 | 1.26761900 |
| 28 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.26492965 |
| 29 | Adherens junction_Homo sapiens_hsa04520 | 1.24373534 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.24073835 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.20298232 |
| 32 | Ribosome_Homo sapiens_hsa03010 | 1.15528737 |
| 33 | HTLV-I infection_Homo sapiens_hsa05166 | 1.14116031 |
| 34 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.11146033 |
| 35 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.06803848 |
| 36 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.05819420 |
| 37 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.05455164 |
| 38 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.05164480 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.04332340 |
| 40 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.02860036 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.00036454 |
| 42 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.99017470 |
| 43 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.98450939 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.98372101 |
| 45 | Thyroid cancer_Homo sapiens_hsa05216 | 0.97708878 |
| 46 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.97143084 |
| 47 | Protein export_Homo sapiens_hsa03060 | 0.96883578 |
| 48 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.96152184 |
| 49 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.92892863 |
| 50 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.92451289 |
| 51 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.92174524 |
| 52 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.89803708 |
| 53 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.89457304 |
| 54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.88728031 |
| 55 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.86279507 |
| 56 | Bladder cancer_Homo sapiens_hsa05219 | 0.86251662 |
| 57 | Colorectal cancer_Homo sapiens_hsa05210 | 0.82265109 |
| 58 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.80208166 |
| 59 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.75409785 |
| 60 | Viral myocarditis_Homo sapiens_hsa05416 | 0.73775243 |
| 61 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.72287574 |
| 62 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.71584214 |
| 63 | Focal adhesion_Homo sapiens_hsa04510 | 0.67475629 |
| 64 | Tight junction_Homo sapiens_hsa04530 | 0.67198108 |
| 65 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.65960742 |
| 66 | Prostate cancer_Homo sapiens_hsa05215 | 0.64597782 |
| 67 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.64318028 |
| 68 | Alcoholism_Homo sapiens_hsa05034 | 0.62760322 |
| 69 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.62513201 |
| 70 | Pathways in cancer_Homo sapiens_hsa05200 | 0.62392710 |
| 71 | Apoptosis_Homo sapiens_hsa04210 | 0.61375525 |
| 72 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.59197718 |
| 73 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.58832721 |
| 74 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.58411894 |
| 75 | Hepatitis B_Homo sapiens_hsa05161 | 0.58368717 |
| 76 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.56333924 |
| 77 | Legionellosis_Homo sapiens_hsa05134 | 0.56061277 |
| 78 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.52546118 |
| 79 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.52076481 |
| 80 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.52000433 |
| 81 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.51329132 |
| 82 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.50572567 |
| 83 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.50548153 |
| 84 | Proteasome_Homo sapiens_hsa03050 | 0.49935129 |
| 85 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.49769267 |
| 86 | Endometrial cancer_Homo sapiens_hsa05213 | 0.49432105 |
| 87 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.48802824 |
| 88 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.48376275 |
| 89 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.47771440 |
| 90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.47034954 |
| 91 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.45438134 |
| 92 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.44982284 |
| 93 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.43612226 |
| 94 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.42544980 |
| 95 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.40037047 |
| 96 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.40033999 |
| 97 | Purine metabolism_Homo sapiens_hsa00230 | 0.39938815 |
| 98 | Amoebiasis_Homo sapiens_hsa05146 | 0.38957726 |
| 99 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.37590206 |
| 100 | Shigellosis_Homo sapiens_hsa05131 | 0.37181676 |
| 101 | Carbon metabolism_Homo sapiens_hsa01200 | 0.36903074 |
| 102 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.35497369 |
| 103 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.34839685 |
| 104 | Melanoma_Homo sapiens_hsa05218 | 0.33926584 |
| 105 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.33024410 |
| 106 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.32811432 |
| 107 | Measles_Homo sapiens_hsa05162 | 0.32137073 |
| 108 | Influenza A_Homo sapiens_hsa05164 | 0.32034881 |
| 109 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.30553238 |
| 110 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.30412898 |
| 111 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.30360313 |
| 112 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.29381210 |
| 113 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.26311606 |
| 114 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.25748701 |
| 115 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.25693658 |
| 116 | Glioma_Homo sapiens_hsa05214 | 0.24993105 |
| 117 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.24549794 |
| 118 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.23480666 |
| 119 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.22056210 |
| 120 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.20696346 |
| 121 | Metabolic pathways_Homo sapiens_hsa01100 | 0.19199493 |
| 122 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.18438948 |
| 123 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.18399898 |
| 124 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.18396437 |
| 125 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.17091577 |
| 126 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.16633663 |
| 127 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.16493926 |
| 128 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.14359176 |

