UTRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.41002005
2vascular endothelial growth factor signaling pathway (GO:0038084)4.07799750
3insulin-like growth factor receptor signaling pathway (GO:0048009)3.96625403
4hemidesmosome assembly (GO:0031581)3.89410197
5cellular response to ethanol (GO:0071361)3.81857139
6histone H3-K36 demethylation (GO:0070544)3.81740869
7regulation of B cell receptor signaling pathway (GO:0050855)3.74810663
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61737826
9negative regulation of cell killing (GO:0031342)3.61737826
10positive regulation of histone deacetylation (GO:0031065)3.59035491
11coronary vasculature morphogenesis (GO:0060977)3.54828280
12interkinetic nuclear migration (GO:0022027)3.49589170
13cell-substrate junction assembly (GO:0007044)3.35941879
14detection of molecule of bacterial origin (GO:0032490)3.30708703
15growth hormone receptor signaling pathway (GO:0060396)3.24868818
16cytoplasmic mRNA processing body assembly (GO:0033962)3.20087652
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16968395
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14117323
19cell adhesion mediated by integrin (GO:0033627)3.11477739
20plasma membrane repair (GO:0001778)3.09646153
21cellular extravasation (GO:0045123)3.09449282
22negative regulation of complement activation (GO:0045916)3.09262679
23cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.08638245
24cell migration involved in sprouting angiogenesis (GO:0002042)3.07138207
25positive regulation of p38MAPK cascade (GO:1900745)3.05078776
26hepatocyte apoptotic process (GO:0097284)3.05065518
27negative regulation of protein activation cascade (GO:2000258)3.02727771
28basement membrane organization (GO:0071711)3.02726087
29monoubiquitinated protein deubiquitination (GO:0035520)2.97738151
30regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.97057097
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95512708
32B cell receptor signaling pathway (GO:0050853)2.95455769
33collagen fibril organization (GO:0030199)2.92549810
34lipid translocation (GO:0034204)2.90646428
35phospholipid translocation (GO:0045332)2.90646428
36positive thymic T cell selection (GO:0045059)2.90201269
37protein heterotrimerization (GO:0070208)2.88048619
38positive regulation of endothelial cell apoptotic process (GO:2000353)2.85795931
39hippo signaling (GO:0035329)2.85590349
40positive regulation of fatty acid beta-oxidation (GO:0032000)2.83071511
41low-density lipoprotein particle clearance (GO:0034383)2.79975450
42regulation of establishment of cell polarity (GO:2000114)2.79673936
43renal filtration (GO:0097205)2.78681970
44cellular response to growth hormone stimulus (GO:0071378)2.77901896
45regulation of tight junction assembly (GO:2000810)2.77244941
46adherens junction assembly (GO:0034333)2.76459013
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76268869
48regulation of necroptotic process (GO:0060544)2.75276220
49positive regulation of glycogen biosynthetic process (GO:0045725)2.75179665
50hypotonic response (GO:0006971)2.74714082
51positive regulation of granulocyte differentiation (GO:0030854)2.74703937
52histone H3-K4 trimethylation (GO:0080182)2.72471529
53fibroblast migration (GO:0010761)2.71434832
54negative regulation of humoral immune response (GO:0002921)2.70373345
55regulation of p38MAPK cascade (GO:1900744)2.70136490
56glomerular filtration (GO:0003094)2.67569330
57NLS-bearing protein import into nucleus (GO:0006607)2.65317877
58negative regulation of stress fiber assembly (GO:0051497)2.64804164
59nucleus localization (GO:0051647)2.64625290
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64515132
61lymph vessel development (GO:0001945)2.64495264
62microglial cell activation (GO:0001774)2.63465307
63histone H3-K9 demethylation (GO:0033169)2.63149241
64definitive hemopoiesis (GO:0060216)2.62943683
65patterning of blood vessels (GO:0001569)2.62155422
66radial glial cell differentiation (GO:0060019)2.60560209
67response to interleukin-15 (GO:0070672)2.60549463
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.60260920
69regulation of establishment or maintenance of cell polarity (GO:0032878)2.60186230
70blood vessel maturation (GO:0001955)2.59442066
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59347062
72endodermal cell differentiation (GO:0035987)2.58766424
73heart morphogenesis (GO:0003007)2.58500889
74negative regulation of DNA repair (GO:0045738)2.57972753
75pathway-restricted SMAD protein phosphorylation (GO:0060389)2.56580197
76cell-substrate adherens junction assembly (GO:0007045)2.55599102
77focal adhesion assembly (GO:0048041)2.55599102
78pericardium development (GO:0060039)2.55200628
79nuclear pore complex assembly (GO:0051292)2.55054982
80regulation of gamma-delta T cell differentiation (GO:0045586)2.54412675
81blood vessel endothelial cell migration (GO:0043534)2.53430170
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52191863
83embryonic camera-type eye morphogenesis (GO:0048596)2.51941124
84ovulation from ovarian follicle (GO:0001542)2.50798725
85negative regulation of vascular permeability (GO:0043116)2.50714910
86negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.50557377
87activated T cell proliferation (GO:0050798)2.50202872
88endocardial cushion development (GO:0003197)2.50037318
89apoptotic cell clearance (GO:0043277)2.48800919
90embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48658146
91positive regulation of receptor recycling (GO:0001921)2.47903125
92T cell selection (GO:0045058)2.46059669
93thymic T cell selection (GO:0045061)2.45897835
94interleukin-6-mediated signaling pathway (GO:0070102)2.44590587
95negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.44406033
96substrate adhesion-dependent cell spreading (GO:0034446)2.44317649
97endothelial tube morphogenesis (GO:0061154)2.44262246
98morphogenesis of an endothelium (GO:0003159)2.44262246
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.43309631
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43309631
101detection of external biotic stimulus (GO:0098581)2.43233994
102retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43092360
103positive T cell selection (GO:0043368)2.42229070
104positive regulation of gamma-delta T cell activation (GO:0046645)2.41035576
105antigen processing and presentation of endogenous antigen (GO:0019883)2.40557080
106negative regulation of B cell proliferation (GO:0030889)2.39882314
107phospholipid homeostasis (GO:0055091)2.39536704
108positive regulation of protein deacetylation (GO:0090312)2.39414334
109macrophage activation (GO:0042116)2.39414094
110carnitine shuttle (GO:0006853)2.38670872
111protein K48-linked deubiquitination (GO:0071108)2.38448226
112regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.37769637
113histone mRNA catabolic process (GO:0071044)2.37707626
114positive regulation of fatty acid oxidation (GO:0046321)2.37584431
115exocrine pancreas development (GO:0031017)2.36811634
116cellular response to epinephrine stimulus (GO:0071872)2.36748785
117iron ion import (GO:0097286)2.35947628
118import into cell (GO:0098657)2.35444912
119fatty acid transmembrane transport (GO:1902001)2.34482169
120histone lysine demethylation (GO:0070076)2.33429897
121negative T cell selection (GO:0043383)2.32574132
122establishment of protein localization to Golgi (GO:0072600)2.32338636
123embryonic process involved in female pregnancy (GO:0060136)2.31561225
124embryonic placenta development (GO:0001892)2.30370438
125regulation of protein polyubiquitination (GO:1902914)2.29201228
126venous blood vessel morphogenesis (GO:0048845)2.28405744
127regulation of fatty acid beta-oxidation (GO:0031998)2.28283021
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.28260859
129protein targeting to Golgi (GO:0000042)2.28260480
130establishment of nucleus localization (GO:0040023)2.28237662
131macrophage activation involved in immune response (GO:0002281)2.27945622
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.27710323
133regulation of T cell tolerance induction (GO:0002664)2.27632620
134positive regulation of tolerance induction (GO:0002645)2.27209318
135negative thymic T cell selection (GO:0045060)2.27175905
136stress fiber assembly (GO:0043149)2.27005491
137epithelial cell-cell adhesion (GO:0090136)2.25862997
138endothelium development (GO:0003158)2.24575514
139regulation of gamma-delta T cell activation (GO:0046643)2.23696280
140vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23561150
141regulation of SMAD protein import into nucleus (GO:0060390)2.22481804
142regulation of complement activation (GO:0030449)2.21630209
143negative regulation of fatty acid transport (GO:2000192)2.21363592
144corticosteroid receptor signaling pathway (GO:0031958)2.21287478
145response to fluid shear stress (GO:0034405)2.20301523
146histone demethylation (GO:0016577)2.19765749
147protein targeting to vacuole (GO:0006623)2.19275308
148protein targeting to lysosome (GO:0006622)2.19275308
149establishment of protein localization to vacuole (GO:0072666)2.19275308
150COPI coating of Golgi vesicle (GO:0048205)2.19271308
151Golgi transport vesicle coating (GO:0048200)2.19271308
152glomerular visceral epithelial cell development (GO:0072015)2.19189645
153positive regulation of glucose import (GO:0046326)2.18925527
154negative regulation of T cell mediated immunity (GO:0002710)2.18901418
155modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.18384200
156positive regulation by organism of defense response of other organism involved in symbiotic interact2.18384200
157modulation by symbiont of host immune response (GO:0052553)2.18384200
158positive regulation by symbiont of host defense response (GO:0052509)2.18384200
159modulation by symbiont of host defense response (GO:0052031)2.18384200
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18384200
161positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.18361189
162axon extension involved in axon guidance (GO:0048846)2.18264656
163neuron projection extension involved in neuron projection guidance (GO:1902284)2.18264656
164T cell migration (GO:0072678)2.17948544
165antigen processing and presentation via MHC class Ib (GO:0002475)2.17423787
166nuclear pore organization (GO:0006999)2.16717939
167positive regulation of hormone biosynthetic process (GO:0046886)2.16402569
168positive regulation of glycogen metabolic process (GO:0070875)2.16174285
169cardiac muscle cell proliferation (GO:0060038)2.15799723
170centrosome localization (GO:0051642)2.15501122
171platelet-derived growth factor receptor signaling pathway (GO:0048008)2.15257752
172negative regulation of myotube differentiation (GO:0010832)2.15172865
173detection of other organism (GO:0098543)2.14734354
174early endosome to late endosome transport (GO:0045022)2.14143940
175regulation of pigment cell differentiation (GO:0050932)2.13967165
176regulation of protein activation cascade (GO:2000257)2.13603122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.36586851
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.83701843
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81588626
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60121126
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58340368
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.81731788
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.74968434
8CLOCK_20551151_ChIP-Seq_293T_Human2.71261065
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.46872100
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27232438
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.19071620
12GATA1_22025678_ChIP-Seq_K562_Human2.15161992
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.14864014
14* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14248773
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.11118174
16* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07375999
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.01311366
18RUNX_20019798_ChIP-Seq_JUKART_Human2.00626539
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99185361
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92271018
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86689825
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.84724801
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84334233
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82862561
25SCL_19346495_ChIP-Seq_HPC-7_Human1.82123789
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77972728
27* IRF8_27001747_Chip-Seq_BMDM_Mouse1.75798338
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.70076142
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69060366
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.67606839
31* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67122962
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65821847
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63844921
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.63220718
35BRD4_25478319_ChIP-Seq_HGPS_Human1.63218892
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59603716
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58830224
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58419852
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56369860
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56369860
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56114757
42TBX20_22328084_ChIP-Seq_HEART_Mouse1.55959429
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.55959429
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52056336
45* CJUN_26792858_Chip-Seq_BT549_Human1.51924202
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51856043
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51025296
48* VDR_24787735_ChIP-Seq_THP-1_Human1.47998196
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47803710
50* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46572566
51* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46094005
52* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45775768
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45519237
54* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43824367
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43325086
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43261190
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.40061145
58* PIAS1_25552417_ChIP-Seq_VCAP_Human1.39496377
59AR_21572438_ChIP-Seq_LNCaP_Human1.39362040
60TP53_16413492_ChIP-PET_HCT116_Human1.37795601
61* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37759699
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.37758914
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.36292353
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34883852
65* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32992938
66* TCF7_22412390_ChIP-Seq_EML_Mouse1.32865159
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32331966
68AHR_22903824_ChIP-Seq_MCF-7_Human1.32034987
69* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31970716
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30034712
71* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29484756
72* KDM2B_26808549_Chip-Seq_DND41_Human1.29400023
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.28689341
74* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26993041
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26683790
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25414887
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25084277
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25063800
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.23901675
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23109871
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23098302
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22865689
83* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20565382
84ZNF263_19887448_ChIP-Seq_K562_Human1.18469497
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17810076
86* ISL1_27105846_Chip-Seq_CPCs_Mouse1.17735466
87* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17233799
88* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17233799
89MYC_22102868_ChIP-Seq_BL_Human1.15167994
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14780161
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13668085
92* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13227339
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12778432
94* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12702090
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12185730
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11818686
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.11293197
98* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10866379
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10186618
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09380745
101* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09332991
102GATA3_27048872_Chip-Seq_THYMUS_Human1.08898393
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06938262
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.06773257
105* GATA2_19941826_ChIP-Seq_K562_Human1.06609320
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.04977071
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04695316
108* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04517643
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04255648
110* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04254190
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04211534
112* UBF1/2_26484160_Chip-Seq_HMECs_Human1.04116387
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03969756
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03019626
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02440694
116SPI1_23127762_ChIP-Seq_K562_Human1.02372731
117* GATA1_19941827_ChIP-Seq_MEL_Mouse1.02089661
118* TP63_23658742_ChIP-Seq_EP156T_Human1.02023043
119* GATA1_19941826_ChIP-Seq_K562_Human1.01530635
120* PU_27001747_Chip-Seq_BMDM_Mouse1.01126244
121STAT3_23295773_ChIP-Seq_U87_Human1.00044500
122RXR_22108803_ChIP-Seq_LS180_Human0.99654409
123* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98205551
124* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97897115
125UTX_26944678_Chip-Seq_JUKART_Human0.97728500
126* LXR_22158963_ChIP-Seq_LIVER_Mouse0.97543704
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97265377
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96716978
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96690189
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96040455
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95723725
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95081283
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95065922
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95012387
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93478574
136* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92412911
137MYB_26560356_Chip-Seq_TH1_Human0.91972177
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91904990
139MAF_26560356_Chip-Seq_TH1_Human0.91744601
140* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91224151
141MYB_26560356_Chip-Seq_TH2_Human0.90691851
142* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89457000
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.88685108
144SMAD4_21799915_ChIP-Seq_A2780_Human0.87716120
145GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86626314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.30105771
2MP0004272_abnormal_basement_membrane3.68096998
3MP0005275_abnormal_skin_tensile3.12612138
4MP0003705_abnormal_hypodermis_morpholog3.02531247
5MP0003045_fibrosis2.88222688
6MP0003300_gastrointestinal_ulcer2.68034414
7MP0005670_abnormal_white_adipose2.60956697
8MP0002166_altered_tumor_susceptibility2.50017311
9MP0008057_abnormal_DNA_replication2.41329685
10MP0010352_gastrointestinal_tract_polyps2.40541693
11MP0003566_abnormal_cell_adhesion2.34250126
12MP0002877_abnormal_melanocyte_morpholog2.21147529
13MP0003279_aneurysm2.16916318
14MP0002009_preneoplasia2.06833260
15MP0000569_abnormal_digit_pigmentation2.05489909
16MP0001835_abnormal_antigen_presentation2.04479372
17MP0009384_cardiac_valve_regurgitation2.03164864
18MP0000013_abnormal_adipose_tissue2.02071669
19MP0005623_abnormal_meninges_morphology2.01625733
20MP0005503_abnormal_tendon_morphology1.98654171
21MP0004084_abnormal_cardiac_muscle1.96415775
22MP0005666_abnormal_adipose_tissue1.95270387
23MP0004185_abnormal_adipocyte_glucose1.94006343
24MP0008260_abnormal_autophagy1.89313303
25MP0002006_tumorigenesis1.86146853
26MP0004883_abnormal_blood_vessel1.83117916
27MP0010234_abnormal_vibrissa_follicle1.79836423
28MP0010368_abnormal_lymphatic_system1.75228964
29MP0000003_abnormal_adipose_tissue1.75209414
30MP0005375_adipose_tissue_phenotype1.74937066
31MP0005409_darkened_coat_color1.74351700
32MP0001879_abnormal_lymphatic_vessel1.68669661
33MP0003828_pulmonary_edema1.67821762
34MP0001851_eye_inflammation1.66927857
35MP0000465_gastrointestinal_hemorrhage1.65895699
36MP0003091_abnormal_cell_migration1.65507596
37MP0005076_abnormal_cell_differentiation1.64128303
38MP0003303_peritoneal_inflammation1.61489379
39MP0004130_abnormal_muscle_cell1.60083308
40MP0001958_emphysema1.57499617
41MP0005023_abnormal_wound_healing1.55162057
42MP0002837_dystrophic_cardiac_calcinosis1.54095368
43MP0005451_abnormal_body_composition1.53437592
44MP0004381_abnormal_hair_follicle1.53393743
45MP0009780_abnormal_chondrocyte_physiolo1.51758527
46MP0006054_spinal_hemorrhage1.50594963
47MP0002060_abnormal_skin_morphology1.47033074
48MP0010630_abnormal_cardiac_muscle1.46456510
49MP0001800_abnormal_humoral_immune1.46004357
50MP0005464_abnormal_platelet_physiology1.45175507
51MP0005164_abnormal_response_to1.44518132
52MP0003950_abnormal_plasma_membrane1.43785884
53MP0000751_myopathy1.42602997
54MP0002933_joint_inflammation1.39830060
55MP0000733_abnormal_muscle_development1.39579540
56MP0003690_abnormal_glial_cell1.39353858
57MP0003172_abnormal_lysosome_physiology1.38981078
58MP0001661_extended_life_span1.36625343
59MP0002108_abnormal_muscle_morphology1.35673883
60MP0003191_abnormal_cellular_cholesterol1.34085753
61MP0002168_other_aberrant_phenotype1.32890728
62MP0003656_abnormal_erythrocyte_physiolo1.28846303
63MP0004087_abnormal_muscle_fiber1.28504169
64MP0009278_abnormal_bone_marrow1.28098689
65MP0004484_altered_response_of1.27623175
66MP0000685_abnormal_immune_system1.27613669
67MP0002419_abnormal_innate_immunity1.24457026
68MP0008961_abnormal_basal_metabolism1.23886370
69MP0003941_abnormal_skin_development1.23666069
70MP0002405_respiratory_system_inflammati1.23177873
71MP0000767_abnormal_smooth_muscle1.21878212
72MP0003436_decreased_susceptibility_to1.20836317
73MP0008775_abnormal_heart_ventricle1.18471333
74MP0006138_congestive_heart_failure1.17403671
75MP0002925_abnormal_cardiovascular_devel1.16621444
76MP0000750_abnormal_muscle_regeneration1.13183985
77MP0005330_cardiomyopathy1.12372370
78MP0000249_abnormal_blood_vessel1.11970297
79MP0003763_abnormal_thymus_physiology1.09412402
80MP0002896_abnormal_bone_mineralization1.08739277
81MP0005310_abnormal_salivary_gland1.06995101
82MP0002723_abnormal_immune_serum1.06870210
83MP0000749_muscle_degeneration1.05717830
84MP0003868_abnormal_feces_composition1.05304711
85MP0002452_abnormal_antigen_presenting1.04819835
86MP0005408_hypopigmentation1.04443114
87MP0002332_abnormal_exercise_endurance1.03893911
88MP0002420_abnormal_adaptive_immunity1.03854766
89MP0001790_abnormal_immune_system1.03075185
90MP0005387_immune_system_phenotype1.03075185
91MP0002128_abnormal_blood_circulation1.02852316
92MP0001544_abnormal_cardiovascular_syste1.02659397
93MP0005385_cardiovascular_system_phenoty1.02659397
94MP0001819_abnormal_immune_cell1.02223392
95MP0004947_skin_inflammation1.02061292
96MP0000371_diluted_coat_color1.01883159
97MP0005388_respiratory_system_phenotype1.01631547
98MP0002133_abnormal_respiratory_system1.01631547
99MP0004808_abnormal_hematopoietic_stem1.00386257
100MP0002398_abnormal_bone_marrow0.99681378
101MP0001299_abnormal_eye_distance/0.99077036
102MP0005025_abnormal_response_to0.98766669
103MP0003283_abnormal_digestive_organ0.98701595
104MP0003183_abnormal_peptide_metabolism0.96968986
105MP0005000_abnormal_immune_tolerance0.95073180
106MP0004264_abnormal_extraembryonic_tissu0.94655055
107MP0003866_abnormal_defecation0.94495197
108MP0000703_abnormal_thymus_morphology0.94289426
109MP0000266_abnormal_heart_morphology0.92630028
110MP0005167_abnormal_blood-brain_barrier0.92352097
111MP0004036_abnormal_muscle_relaxation0.91982647
112MP0001533_abnormal_skeleton_physiology0.91672755
113MP0000015_abnormal_ear_pigmentation0.91235867
114MP0000716_abnormal_immune_system0.90826693
115MP0004215_abnormal_myocardial_fiber0.88214778
116MP0002972_abnormal_cardiac_muscle0.87728761
117MP0008004_abnormal_stomach_pH0.87686668
118MP0002086_abnormal_extraembryonic_tissu0.86521544
119MP0000689_abnormal_spleen_morphology0.85969287
120MP0010155_abnormal_intestine_physiology0.85834296
121MP0010307_abnormal_tumor_latency0.84815003
122MP0000858_altered_metastatic_potential0.84577158
123MP0000516_abnormal_urinary_system0.84231560
124MP0005367_renal/urinary_system_phenotyp0.84231560
125MP0003221_abnormal_cardiomyocyte_apopto0.84225121
126MP0001614_abnormal_blood_vessel0.83810932
127MP0002722_abnormal_immune_system0.83635510
128MP0005621_abnormal_cell_physiology0.81893016
129MP0009115_abnormal_fat_cell0.81625005
130MP0005174_abnormal_tail_pigmentation0.81613779
131MP0003567_abnormal_fetal_cardiomyocyte0.80488018
132MP0002928_abnormal_bile_duct0.79903770
133MP0005508_abnormal_skeleton_morphology0.79893262
134MP0003935_abnormal_craniofacial_develop0.78525116
135MP0002971_abnormal_brown_adipose0.77605935
136MP0002127_abnormal_cardiovascular_syste0.76648320
137MP0002269_muscular_atrophy0.76251695
138MP0001243_abnormal_dermal_layer0.75529015
139MP0002088_abnormal_embryonic_growth/wei0.74798469
140MP0001784_abnormal_fluid_regulation0.74622786
141MP0001915_intracranial_hemorrhage0.74341121
142MP0005620_abnormal_muscle_contractility0.73734840
143MP0003984_embryonic_growth_retardation0.73524956
144MP0003453_abnormal_keratinocyte_physiol0.71153974
145MP0001545_abnormal_hematopoietic_system0.70389358
146MP0005397_hematopoietic_system_phenotyp0.70389358
147MP0003252_abnormal_bile_duct0.69713584
148MP0004197_abnormal_fetal_growth/weight/0.69508620
149MP0002998_abnormal_bone_remodeling0.67520725
150MP0000428_abnormal_craniofacial_morphol0.66340561
151MP0002396_abnormal_hematopoietic_system0.65484393
152MP0000759_abnormal_skeletal_muscle0.64703636
153MP0003724_increased_susceptibility_to0.63495904
154MP0009703_decreased_birth_body0.63344689
155MP0001270_distended_abdomen0.63015774

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.40887441
2Aortic aneurysm (HP:0004942)3.79999495
3Protrusio acetabuli (HP:0003179)3.64225220
4Increased connective tissue (HP:0009025)3.52686799
5Ulnar claw (HP:0001178)3.52605577
6Spontaneous hematomas (HP:0007420)3.43031042
7Aortic dissection (HP:0002647)3.42024976
8Atrophic scars (HP:0001075)3.36693546
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.31796587
10Ankle contracture (HP:0006466)3.29850128
11Broad metatarsal (HP:0001783)3.25130731
12Premature rupture of membranes (HP:0001788)3.16243247
13Mitral valve prolapse (HP:0001634)3.04863383
14Gingival bleeding (HP:0000225)2.99677205
15Shallow orbits (HP:0000586)2.99126066
16Aneurysm (HP:0002617)2.88112233
17Conjunctival telangiectasia (HP:0000524)2.87437535
18Eczematoid dermatitis (HP:0000976)2.85235849
19Hematochezia (HP:0002573)2.83758033
20Arterial tortuosity (HP:0005116)2.80207307
21Segmental peripheral demyelination/remyelination (HP:0003481)2.79894870
22Dilatation of the ascending aorta (HP:0005111)2.77949149
23Papillary thyroid carcinoma (HP:0002895)2.77178374
24Hyporeflexia of lower limbs (HP:0002600)2.75472123
25Increased CSF protein (HP:0002922)2.74225113
26Abnormality of the fingertips (HP:0001211)2.70049101
27Peritonitis (HP:0002586)2.64930066
28Abnormality of the vasculature of the conjunctiva (HP:0008054)2.61802093
29Colitis (HP:0002583)2.57110210
30Hypoplastic ischia (HP:0003175)2.53181562
31Recurrent bacterial skin infections (HP:0005406)2.50728795
32Right ventricular cardiomyopathy (HP:0011663)2.49008956
33Fragile skin (HP:0001030)2.46840109
34Glucose intolerance (HP:0000833)2.46709292
35Dislocated radial head (HP:0003083)2.43715933
36Gastrointestinal infarctions (HP:0005244)2.41213925
37Abnormality of the ischium (HP:0003174)2.39253651
38Gingivitis (HP:0000230)2.36444874
39Macroorchidism (HP:0000053)2.31098738
40Epistaxis (HP:0000421)2.30659741
41Difficulty running (HP:0009046)2.30475548
42Spinal rigidity (HP:0003306)2.28961944
43Cervical subluxation (HP:0003308)2.28532162
44Prolonged bleeding time (HP:0003010)2.25459110
45Termporal pattern (HP:0011008)2.24323422
46Insidious onset (HP:0003587)2.24323422
47Bladder diverticulum (HP:0000015)2.23260813
48Abnormal glucose tolerance (HP:0001952)2.23012594
49Subacute progressive viral hepatitis (HP:0006572)2.22992597
50Rectal prolapse (HP:0002035)2.21215302
51Mildly elevated creatine phosphokinase (HP:0008180)2.19392268
52Viral hepatitis (HP:0006562)2.18478255
53Esophageal varix (HP:0002040)2.17514704
54Abnormality of the radial head (HP:0003995)2.16798671
55Menorrhagia (HP:0000132)2.16595857
56Striae distensae (HP:0001065)2.15977148
57Narrow palate (HP:0000189)2.15283080
58Recurrent abscess formation (HP:0002722)2.15139588
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.14579218
60Osteolytic defects of the hand bones (HP:0009699)2.14579218
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14490496
62Short 4th metacarpal (HP:0010044)2.14490496
63Periodontitis (HP:0000704)2.14208051
64Myocardial infarction (HP:0001658)2.14039096
65Flat acetabular roof (HP:0003180)2.13855430
66Type 1 muscle fiber predominance (HP:0003803)2.10075225
67Impaired proprioception (HP:0010831)2.08989659
68Insulin-resistant diabetes mellitus (HP:0000831)2.08827163
69Bowel diverticulosis (HP:0005222)2.08117314
70Recurrent gram-negative bacterial infections (HP:0005420)2.05267552
71Arterial thrombosis (HP:0004420)2.05100181
72Acute myeloid leukemia (HP:0004808)2.03147530
73Optic neuritis (HP:0100653)2.02557446
74Retrobulbar optic neuritis (HP:0100654)2.02557446
75Muscle fiber splitting (HP:0003555)2.02404990
76Enlarged penis (HP:0000040)2.01947404
77Recurrent fungal infections (HP:0002841)2.01074380
78Thin bony cortex (HP:0002753)1.98586404
79Acanthosis nigricans (HP:0000956)1.98348007
80Neonatal hypoglycemia (HP:0001998)1.96303458
81Lipoatrophy (HP:0100578)1.95926906
82Portal hypertension (HP:0001409)1.95411487
83Recurrent bronchitis (HP:0002837)1.94508244
84Broad face (HP:0000283)1.94420840
85Abnormality of the nasal septum (HP:0000419)1.94383508
86Spinal cord lesions (HP:0100561)1.94297002
87Syringomyelia (HP:0003396)1.94297002
88Genetic anticipation (HP:0003743)1.94244968
89Urethral obstruction (HP:0000796)1.93731743
90Slow saccadic eye movements (HP:0000514)1.92049439
91Abnormality of the common coagulation pathway (HP:0010990)1.91966789
92Long eyelashes (HP:0000527)1.91880499
93Coarse hair (HP:0002208)1.91705209
94Myositis (HP:0100614)1.91206213
95Hypoplasia of the iris (HP:0007676)1.90576048
96Mesomelia (HP:0003027)1.89070801
97Orchitis (HP:0100796)1.89023390
98Abnormality of secondary sexual hair (HP:0009888)1.88335828
99Abnormality of the axillary hair (HP:0100134)1.88335828
100Thoracolumbar scoliosis (HP:0002944)1.87629915
101Deep venous thrombosis (HP:0002625)1.87064283
102Overgrowth (HP:0001548)1.86599390
103Soft skin (HP:0000977)1.86262301
104Increased variability in muscle fiber diameter (HP:0003557)1.86181447
105Scapular winging (HP:0003691)1.85968064
106Interstitial pulmonary disease (HP:0006530)1.84230211
107Delayed closure of the anterior fontanelle (HP:0001476)1.84019264
108Abnormality of the peritoneum (HP:0002585)1.83249746
109Inflammation of the large intestine (HP:0002037)1.82402271
110Radial bowing (HP:0002986)1.81316261
111Genu recurvatum (HP:0002816)1.80078988
112Dysmetric saccades (HP:0000641)1.79724885
113Recurrent skin infections (HP:0001581)1.79368742
114Abnormality of the hepatic vasculature (HP:0006707)1.78901324
115Abnormality of T cells (HP:0002843)1.78867456
116Mitral stenosis (HP:0001718)1.78767604
117Recurrent viral infections (HP:0004429)1.78664058
118Abnormal delayed hypersensitivity skin test (HP:0002963)1.78580079
119Chronic mucocutaneous candidiasis (HP:0002728)1.78211397
120Recurrent cutaneous fungal infections (HP:0011370)1.78211397
121Milia (HP:0001056)1.78173180
122Distal lower limb amyotrophy (HP:0008944)1.78103892
123Abnormality of the 4th metacarpal (HP:0010012)1.77411033
124Action tremor (HP:0002345)1.76379631
125Broad palm (HP:0001169)1.75177813
126Hyperglycemia (HP:0003074)1.74685230
127Reduced subcutaneous adipose tissue (HP:0003758)1.73674247
128Abnormal platelet volume (HP:0011876)1.73637021
129Vertebral arch anomaly (HP:0008438)1.73533732
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73291074
131Increased density of long bones (HP:0006392)1.73103261
132Abnormality of skeletal muscle fiber size (HP:0012084)1.72435769
133Submucous cleft hard palate (HP:0000176)1.72328711
134Absent frontal sinuses (HP:0002688)1.72040024
135Autoimmune hemolytic anemia (HP:0001890)1.71313492
136Hyperkalemia (HP:0002153)1.70369654
137Hammertoe (HP:0001765)1.69798693
138Long toe (HP:0010511)1.69374037
139Camptodactyly of toe (HP:0001836)1.68660323
140T lymphocytopenia (HP:0005403)1.67879075
141Joint laxity (HP:0001388)1.67701053
142Wrist flexion contracture (HP:0001239)1.67487095
143Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.66951227
144Broad ribs (HP:0000885)1.66922148
145Difficulty climbing stairs (HP:0003551)1.66643443
146Abnormal foot bone ossification (HP:0010675)1.66318473
147Pulmonary embolism (HP:0002204)1.65794210
148Gastrointestinal inflammation (HP:0004386)1.65488482
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64683403
150Wormian bones (HP:0002645)1.64674396
151Blue sclerae (HP:0000592)1.64631652
152Pancreatic islet-cell hyperplasia (HP:0004510)1.63961895
153Spondylolisthesis (HP:0003302)1.63703066
154Increased mean platelet volume (HP:0011877)1.63260136
155Bicuspid aortic valve (HP:0001647)1.62746842
156Persistence of primary teeth (HP:0006335)1.62610715
157Hypoglycemic coma (HP:0001325)1.62003558
158Lymphangioma (HP:0100764)1.61468086
159Ectopia lentis (HP:0001083)1.61294578
160Ventricular tachycardia (HP:0004756)1.61267379
161Ulnar bowing (HP:0003031)1.60590784
162Facial diplegia (HP:0001349)1.58288874
163Abnormality of T cell number (HP:0011839)1.57216267
164Biliary tract neoplasm (HP:0100574)1.56967986
165Foot dorsiflexor weakness (HP:0009027)1.55635034
166Alopecia of scalp (HP:0002293)1.55019213
167Truncal obesity (HP:0001956)1.53525407
168Lumbar hyperlordosis (HP:0002938)1.53487864
169Hypoplastic labia majora (HP:0000059)1.53258073
170Vascular tortuosity (HP:0004948)1.53019914
171Skull defect (HP:0001362)1.51593608
172Ureteral obstruction (HP:0006000)1.51088693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN2.99209179
2CAMK1D2.92625304
3FRK2.70536795
4TRIB32.53575927
5RIPK12.44987271
6LATS12.43195188
7SIK12.42287229
8FGFR32.36257278
9BLK2.33486996
10PDGFRA2.32459277
11CAMK1G2.28714665
12CDK122.24253401
13FGFR42.15367353
14INSRR2.07355246
15TIE12.01072566
16PKN21.91920904
17PIK3CG1.91690247
18DMPK1.87814773
19FGFR21.82200985
20TGFBR21.73098530
21FES1.61042612
22PTK61.58651044
23RIPK41.58409103
24JAK11.56942518
25LMTK21.53866701
26JAK31.49296041
27STK101.45849908
28PDGFRB1.45647614
29NUAK11.38997605
30DDR21.38643016
31BTK1.34757744
32EEF2K1.33786593
33MAP3K101.32570460
34MTOR1.28455622
35ITK1.26102346
36SGK4941.20869498
37SGK2231.20869498
38PIK3CA1.20758581
39FGR1.20405794
40PRKCH1.17193214
41KDR1.16085336
42GRK61.12491637
43PTK21.11131372
44FLT31.10681173
45ZAK1.09409630
46CDK61.08253288
47PTK2B1.07339477
48STK381.07050344
49TRPM71.06649098
50MAP3K141.06421965
51SYK1.05553886
52LRRK21.04683805
53STK31.00322545
54CAMKK20.98921951
55MYLK0.97639359
56MAP3K130.97590313
57TGFBR10.96214070
58PAK20.95755625
59FGFR10.95716310
60EPHA30.95636745
61RET0.94484245
62MAP3K60.93624264
63NEK90.93576519
64NLK0.90400678
65FER0.88637169
66CDK90.84685995
67TYK20.83958864
68SGK30.83321680
69MAP4K10.81940484
70STK40.79650416
71KIT0.78621856
72ERN10.78096181
73PRKAA20.76998206
74MET0.76992095
75PDK10.76946403
76BRD40.76528513
77YES10.76461284
78ACVR1B0.76442615
79WNK10.76127970
80TAOK30.74656711
81MAP3K70.73767566
82OBSCN0.72035344
83TXK0.71724796
84ZAP700.71620398
85EPHA20.70619066
86PRKD10.69878237
87BMPR20.69551799
88MAP3K20.69351216
89PRKD30.68868903
90CSK0.68598176
91CHUK0.68163780
92EPHB10.64868417
93MARK30.63976166
94SCYL20.63772980
95INSR0.63534358
96PRKG20.63516210
97CDC42BPA0.62583787
98LYN0.62275165
99ROCK10.61973099
100SGK10.61317889
101PRKD20.60389989
102PASK0.60249779
103EGFR0.58730032
104MAP3K30.58130274
105CAMK40.57943747
106MAPK110.57882028
107IGF1R0.57622640
108IRAK10.57537785
109RPS6KB20.57431709
110JAK20.57221771
111IKBKE0.57194916
112NEK60.56269961
113PDPK10.55219561
114PRPF4B0.53820527
115MST1R0.53001637
116ICK0.52944701
117MAP3K10.52512886
118BMX0.52419215
119TEC0.50829922
120MAPK120.50437871
121SGK20.49154024
122PIM10.48139120
123PRKAA10.48081436
124GSK3A0.48014326
125PAK30.47781960
126MAP2K30.47679729
127PAK40.47388754
128HIPK20.46350763
129STK110.45440062
130IRAK40.45389493
131AKT30.44173328
132LCK0.43686422
133TNK20.43301052
134GRK50.43045297
135MELK0.42765226
136MAPK70.40437677
137ERBB20.39084018
138SRC0.37606268
139HCK0.37389725

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.72660750
2Adherens junction_Homo sapiens_hsa045202.37114501
3Focal adhesion_Homo sapiens_hsa045102.29126364
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98163563
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.97123252
6Small cell lung cancer_Homo sapiens_hsa052221.95038300
7Dilated cardiomyopathy_Homo sapiens_hsa054141.93797238
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.84578898
9Viral myocarditis_Homo sapiens_hsa054161.79512028
10B cell receptor signaling pathway_Homo sapiens_hsa046621.71564249
11Proteoglycans in cancer_Homo sapiens_hsa052051.66104355
12Protein digestion and absorption_Homo sapiens_hsa049741.65113497
13Insulin resistance_Homo sapiens_hsa049311.61114707
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.57968571
15Staphylococcus aureus infection_Homo sapiens_hsa051501.57899098
16Complement and coagulation cascades_Homo sapiens_hsa046101.51385826
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48742882
18Lysine degradation_Homo sapiens_hsa003101.48332953
19Leishmaniasis_Homo sapiens_hsa051401.47713421
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47485088
21Amoebiasis_Homo sapiens_hsa051461.42314553
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42046651
23Chronic myeloid leukemia_Homo sapiens_hsa052201.38533181
24Toxoplasmosis_Homo sapiens_hsa051451.33712902
25MicroRNAs in cancer_Homo sapiens_hsa052061.31283890
26Type II diabetes mellitus_Homo sapiens_hsa049301.30075350
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29393354
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28702143
29Platelet activation_Homo sapiens_hsa046111.28297977
30Fatty acid biosynthesis_Homo sapiens_hsa000611.26394124
31mTOR signaling pathway_Homo sapiens_hsa041501.25484388
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21571846
33Malaria_Homo sapiens_hsa051441.20512102
34Dorso-ventral axis formation_Homo sapiens_hsa043201.18906804
35Endometrial cancer_Homo sapiens_hsa052131.14176593
36AMPK signaling pathway_Homo sapiens_hsa041521.12939485
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.11555737
38Tight junction_Homo sapiens_hsa045301.09528314
39Prostate cancer_Homo sapiens_hsa052151.09260837
40Choline metabolism in cancer_Homo sapiens_hsa052311.07634197
41Pancreatic cancer_Homo sapiens_hsa052121.06823094
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06795222
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06519226
44TGF-beta signaling pathway_Homo sapiens_hsa043501.05647077
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05578281
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04630288
47Insulin signaling pathway_Homo sapiens_hsa049101.02487562
48Rap1 signaling pathway_Homo sapiens_hsa040151.01606639
49PPAR signaling pathway_Homo sapiens_hsa033201.01419005
50T cell receptor signaling pathway_Homo sapiens_hsa046601.00691622
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99786986
52Pathways in cancer_Homo sapiens_hsa052000.99268780
53Influenza A_Homo sapiens_hsa051640.98183595
54Thyroid cancer_Homo sapiens_hsa052160.96547781
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96206704
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95831268
57Hippo signaling pathway_Homo sapiens_hsa043900.95650524
58Graft-versus-host disease_Homo sapiens_hsa053320.95135908
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94472755
60Notch signaling pathway_Homo sapiens_hsa043300.92144001
61Tuberculosis_Homo sapiens_hsa051520.91932797
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.91488952
63Glucagon signaling pathway_Homo sapiens_hsa049220.90909302
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89758368
65Acute myeloid leukemia_Homo sapiens_hsa052210.88988235
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88816896
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88318747
68Basal cell carcinoma_Homo sapiens_hsa052170.88257618
69HTLV-I infection_Homo sapiens_hsa051660.87172090
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84794774
71Chemokine signaling pathway_Homo sapiens_hsa040620.83741047
72ErbB signaling pathway_Homo sapiens_hsa040120.83570791
73FoxO signaling pathway_Homo sapiens_hsa040680.83147436
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82870219
75Colorectal cancer_Homo sapiens_hsa052100.82208659
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81871112
77HIF-1 signaling pathway_Homo sapiens_hsa040660.81547019
78Estrogen signaling pathway_Homo sapiens_hsa049150.80331550
79Renin secretion_Homo sapiens_hsa049240.80118722
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78842449
81Prolactin signaling pathway_Homo sapiens_hsa049170.78714551
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.77738647
83Glioma_Homo sapiens_hsa052140.77201209
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.76852287
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76458856
86GnRH signaling pathway_Homo sapiens_hsa049120.76045290
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76012240
88Melanoma_Homo sapiens_hsa052180.76002577
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75933517
90Circadian rhythm_Homo sapiens_hsa047100.74427237
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.74020926
92Osteoclast differentiation_Homo sapiens_hsa043800.73690348
93Measles_Homo sapiens_hsa051620.72701435
94Primary immunodeficiency_Homo sapiens_hsa053400.71039523
95Renal cell carcinoma_Homo sapiens_hsa052110.70159580
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.70097116
97Hepatitis B_Homo sapiens_hsa051610.68777769
98Inositol phosphate metabolism_Homo sapiens_hsa005620.68558358
99Renin-angiotensin system_Homo sapiens_hsa046140.67864459
100Bladder cancer_Homo sapiens_hsa052190.67608825
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67093564
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66170570
103Non-small cell lung cancer_Homo sapiens_hsa052230.66130072
104Autoimmune thyroid disease_Homo sapiens_hsa053200.65418677
105Nitrogen metabolism_Homo sapiens_hsa009100.65364017
106Caffeine metabolism_Homo sapiens_hsa002320.65321991
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65279679
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.65155525
109Other glycan degradation_Homo sapiens_hsa005110.64492136
110Viral carcinogenesis_Homo sapiens_hsa052030.64157864
111TNF signaling pathway_Homo sapiens_hsa046680.63730042
112Glycerolipid metabolism_Homo sapiens_hsa005610.63077002
113Hematopoietic cell lineage_Homo sapiens_hsa046400.62266737
114Long-term potentiation_Homo sapiens_hsa047200.61469279
115Thyroid hormone synthesis_Homo sapiens_hsa049180.60014752
116Fatty acid metabolism_Homo sapiens_hsa012120.59824545
117ABC transporters_Homo sapiens_hsa020100.58911615
118Pertussis_Homo sapiens_hsa051330.58193663
119VEGF signaling pathway_Homo sapiens_hsa043700.58080228
120Melanogenesis_Homo sapiens_hsa049160.57656511
121Allograft rejection_Homo sapiens_hsa053300.57052266
122Herpes simplex infection_Homo sapiens_hsa051680.56718144
123Hepatitis C_Homo sapiens_hsa051600.55750000
124Wnt signaling pathway_Homo sapiens_hsa043100.54816766
125Apoptosis_Homo sapiens_hsa042100.54496524
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.54228574
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53685659
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.53105358
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52336650
130Fatty acid degradation_Homo sapiens_hsa000710.51000286

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