UTS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)6.86409348
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.18684965
3regulation of RIG-I signaling pathway (GO:0039535)5.82991887
4synaptic vesicle maturation (GO:0016188)5.66748028
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.60268282
6ATP synthesis coupled proton transport (GO:0015986)5.60268282
7neurotransmitter secretion (GO:0007269)5.46256055
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.29827937
9neutrophil activation involved in immune response (GO:0002283)5.23864496
10regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.89133995
11respiratory electron transport chain (GO:0022904)4.84702693
12mast cell activation (GO:0045576)4.82051662
13synaptic vesicle exocytosis (GO:0016079)4.81201702
14electron transport chain (GO:0022900)4.68900580
15regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.67006536
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66448959
17positive regulation of hormone biosynthetic process (GO:0046886)4.53650119
18negative regulation of T cell mediated immunity (GO:0002710)4.52308425
19neuronal action potential propagation (GO:0019227)4.49214795
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.45627328
21cellular potassium ion homeostasis (GO:0030007)4.44380769
22righting reflex (GO:0060013)4.36387836
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35160586
24protein localization to synapse (GO:0035418)4.31360848
25neuromuscular synaptic transmission (GO:0007274)4.30833907
26mature B cell differentiation involved in immune response (GO:0002313)4.29170466
27immunoglobulin mediated immune response (GO:0016064)4.24394899
28glutamate secretion (GO:0014047)4.23053683
29regulation of synaptic vesicle exocytosis (GO:2000300)4.17574858
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.17377416
31neurotransmitter-gated ion channel clustering (GO:0072578)4.16573802
32positive regulation of gamma-delta T cell activation (GO:0046645)4.14703101
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07133807
34layer formation in cerebral cortex (GO:0021819)4.04411982
35neuromuscular process controlling posture (GO:0050884)4.03263444
36cellular response to interleukin-15 (GO:0071350)3.99304618
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.96186696
38cell communication by electrical coupling (GO:0010644)3.95293554
39mast cell activation involved in immune response (GO:0002279)3.92401338
40mast cell degranulation (GO:0043303)3.92401338
41positive regulation of type 2 immune response (GO:0002830)3.91311900
42regulation of hypersensitivity (GO:0002883)3.89848579
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.88263206
44regulation of neurotransmitter levels (GO:0001505)3.87438765
45neurotransmitter transport (GO:0006836)3.83931319
46positive regulation of glycolytic process (GO:0045821)3.83836153
47neutrophil activation (GO:0042119)3.76070983
48response to interleukin-15 (GO:0070672)3.75873068
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73708058
50regulation of vesicle fusion (GO:0031338)3.72558109
51B cell mediated immunity (GO:0019724)3.71173434
52intermediate filament organization (GO:0045109)3.69987900
53response to peptidoglycan (GO:0032494)3.67869943
54vitamin catabolic process (GO:0009111)3.63913293
55fat-soluble vitamin catabolic process (GO:0042363)3.63913293
56ATP biosynthetic process (GO:0006754)3.62668308
57axon cargo transport (GO:0008088)3.62205264
58mRNA transcription from RNA polymerase II promoter (GO:0042789)3.62134445
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.60394876
60positive regulation of mast cell degranulation (GO:0043306)3.60394876
61positive regulation of mast cell activation (GO:0033005)3.60102561
62cerebellar Purkinje cell differentiation (GO:0021702)3.57581403
63regulation of B cell receptor signaling pathway (GO:0050855)3.56080777
64interferon-gamma-mediated signaling pathway (GO:0060333)3.53571599
65positive regulation of synapse maturation (GO:0090129)3.53163220
66negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.51415491
67negative regulation of calcium ion transmembrane transport (GO:1903170)3.51415491
68mature B cell differentiation (GO:0002335)3.50121726
69adult walking behavior (GO:0007628)3.49956707
70positive regulation of protein sumoylation (GO:0033235)3.43361647
71regulation of voltage-gated calcium channel activity (GO:1901385)3.41459065
72positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.39755163
73positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37499009
74granulocyte activation (GO:0036230)3.35991236
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35431169
76regulation of synaptic vesicle transport (GO:1902803)3.35271037
77leukocyte degranulation (GO:0043299)3.34772502
78positive regulation of response to biotic stimulus (GO:0002833)3.34068941
79positive regulation of hormone metabolic process (GO:0032352)3.33112568
80positive regulation of T cell mediated cytotoxicity (GO:0001916)3.32527617
81regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31591579
82nerve growth factor signaling pathway (GO:0038180)3.31487519
83neurotransmitter biosynthetic process (GO:0042136)3.31247650
84myeloid cell activation involved in immune response (GO:0002275)3.30776443
85negative regulation of cytokine production involved in immune response (GO:0002719)3.30109451
86antigen processing and presentation via MHC class Ib (GO:0002475)3.29613862
87positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.29237991
88positive regulation of T-helper 1 type immune response (GO:0002827)3.28944392
89potassium ion homeostasis (GO:0055075)3.27918473
90adenine nucleotide transport (GO:0051503)3.25575197
91mRNA transcription (GO:0009299)3.24413569
92tricarboxylic acid cycle (GO:0006099)3.23416363
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.21807739
94negative regulation of glycoprotein biosynthetic process (GO:0010561)3.21419305
95activation of protein kinase A activity (GO:0034199)3.21297536
96regulation of cell communication by electrical coupling (GO:0010649)3.20692615
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.20474884
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20051647
99negative regulation of cell killing (GO:0031342)3.20051647
100regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.19979636
101positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.17481890
102regulation of alpha-beta T cell proliferation (GO:0046640)3.17376799
103regulation of T cell mediated cytotoxicity (GO:0001914)3.17225581
104positive regulation of B cell mediated immunity (GO:0002714)3.17130531
105positive regulation of immunoglobulin mediated immune response (GO:0002891)3.17130531
106regulation of interleukin-2 biosynthetic process (GO:0045076)3.17035642
107lymphocyte chemotaxis (GO:0048247)3.16669143
108hydrogen ion transmembrane transport (GO:1902600)3.15893793
109purine nucleotide transport (GO:0015865)3.15889260
110regulation of mast cell activation (GO:0033003)3.15457383
111locomotory exploration behavior (GO:0035641)3.14806173
112tolerance induction (GO:0002507)3.14635868
113positive regulation of granulocyte differentiation (GO:0030854)3.14225860
114ATP hydrolysis coupled proton transport (GO:0015991)3.14114865
115energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14114865
116respiratory system process (GO:0003016)3.13516779
117regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.12659558
118negative regulation of cation channel activity (GO:2001258)3.10866079
119negative regulation of interleukin-12 production (GO:0032695)3.10358927
120regulation of leukocyte mediated cytotoxicity (GO:0001910)3.09960731
121activated T cell proliferation (GO:0050798)3.09303941
122leukocyte aggregation (GO:0070486)3.08583457
123cellular ketone body metabolic process (GO:0046950)3.08472690
124negative regulation of lymphocyte mediated immunity (GO:0002707)3.08072118
125mitochondrial genome maintenance (GO:0000002)3.07874932
126T cell costimulation (GO:0031295)3.05590700
127positive regulation of dendritic spine morphogenesis (GO:0061003)3.04996534
128CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.04881406
129T-helper cell differentiation (GO:0042093)3.04881406
130cell communication involved in cardiac conduction (GO:0086065)3.03701112
131startle response (GO:0001964)3.02957765
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02855200
133sodium ion export (GO:0071436)3.02436293
134detection of bacterium (GO:0016045)3.02413026
135lymphocyte costimulation (GO:0031294)3.01579425
136detection of other organism (GO:0098543)3.00816390
137positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99995302
138regulation of gamma-delta T cell activation (GO:0046643)2.99192412
139positive regulation of T cell cytokine production (GO:0002726)2.98632766
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96820604
141cerebellar Purkinje cell layer development (GO:0021680)2.96728459
142neurotransmitter metabolic process (GO:0042133)2.95244531
143regulation of glutamate receptor signaling pathway (GO:1900449)2.94697480
144regulation of mast cell degranulation (GO:0043304)2.94020724
145succinate metabolic process (GO:0006105)2.93679684
146regulation of natural killer cell mediated immunity (GO:0002715)2.93295923
147regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93295923
148opioid receptor signaling pathway (GO:0038003)2.92613578
149purine ribonucleotide transport (GO:0015868)2.91694220
150positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91455258
151regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91400637
152oxidative phosphorylation (GO:0006119)2.90512025
153sulfation (GO:0051923)2.90121775
154regulation of T-helper 1 type immune response (GO:0002825)2.89212028
155neuron-neuron synaptic transmission (GO:0007270)2.89039396
156membrane hyperpolarization (GO:0060081)2.87065204
157positive thymic T cell selection (GO:0045059)2.87031018
158regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86766277
159positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.84790982
160production of molecular mediator involved in inflammatory response (GO:0002532)2.84579662
161purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.84514968
162negative regulation of glycoprotein metabolic process (GO:1903019)2.83385966
163regulation of relaxation of muscle (GO:1901077)2.83252847
164cellular response to interferon-gamma (GO:0071346)2.81279956
165antigen receptor-mediated signaling pathway (GO:0050851)2.80498387
166regulation of calcium ion transmembrane transport (GO:1903169)2.80395100
167regulation of calcium ion transmembrane transporter activity (GO:1901019)2.80395100
168neuron cell-cell adhesion (GO:0007158)2.80128427
169response to dietary excess (GO:0002021)2.80090438
170purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78868352
171negative regulation of alpha-beta T cell activation (GO:0046636)2.78335411
172positive regulation of natural killer cell mediated immunity (GO:0002717)2.77415257
173negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77200809
174creatine metabolic process (GO:0006600)2.77183087
175positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76164308
176positive regulation of cell killing (GO:0031343)2.75606700
177signal release (GO:0023061)2.75593327
178negative regulation of interleukin-2 production (GO:0032703)2.75569755
179positive regulation of interleukin-10 production (GO:0032733)2.74171788
180regulation of cell killing (GO:0031341)2.74049598
181vocalization behavior (GO:0071625)2.73474062
182regulation of tolerance induction (GO:0002643)2.71871443
183regulation of inflammatory response to antigenic stimulus (GO:0002861)2.71424570
184regulation of mast cell activation involved in immune response (GO:0033006)2.70509223
185negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.70300078
186T cell receptor signaling pathway (GO:0050852)2.69869660
187positive regulation of vesicle fusion (GO:0031340)2.69753801
188positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.69397622
189positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.69309869
190cellular response to nerve growth factor stimulus (GO:1990090)2.69163218
191response to nerve growth factor (GO:1990089)2.69163218
192regulation of T cell tolerance induction (GO:0002664)2.67854352
193regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.66776734
194positive regulation of membrane potential (GO:0045838)2.63881223
195oxaloacetate metabolic process (GO:0006107)2.62591583
196ionotropic glutamate receptor signaling pathway (GO:0035235)2.60161270
197positive regulation of action potential (GO:0045760)2.59799186
198regulation of sodium ion transmembrane transporter activity (GO:2000649)2.58947170
199reflex (GO:0060004)2.58565032
200regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58407760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.30710078
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.16601455
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.67805090
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.54409238
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.31068206
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.08379655
7IRF8_21731497_ChIP-ChIP_J774_Mouse4.04050051
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.79598758
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.46330542
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.45695575
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05832405
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00125046
13GATA1_22025678_ChIP-Seq_K562_Human2.90015354
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89607124
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89607124
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.85614397
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82096451
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77123083
19SPI1_23547873_ChIP-Seq_NB4_Human2.75228934
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74608076
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.72456928
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.69444635
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68542902
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67711921
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62459801
26MYB_26560356_Chip-Seq_TH2_Human2.62417970
27GBX2_23144817_ChIP-Seq_PC3_Human2.60767155
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59769200
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57864613
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55181302
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51737984
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.47373767
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46317683
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44199555
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43835382
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42729038
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.41003408
38ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39030105
39SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37780296
40MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34925573
41REST_21632747_ChIP-Seq_MESCs_Mouse2.34785860
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33662528
43TAF15_26573619_Chip-Seq_HEK293_Human2.28832541
44EZH2_27304074_Chip-Seq_ESCs_Mouse2.21077693
45GABP_17652178_ChIP-ChIP_JURKAT_Human2.17592756
46RUNX_20019798_ChIP-Seq_JUKART_Human2.13037842
47REST_18959480_ChIP-ChIP_MESCs_Mouse2.08167029
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05628906
49BP1_19119308_ChIP-ChIP_Hs578T_Human2.05480543
50GATA3_26560356_Chip-Seq_TH2_Human2.02805842
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02689293
52DROSHA_22980978_ChIP-Seq_HELA_Human2.02644869
53RNF2_27304074_Chip-Seq_ESCs_Mouse2.01483278
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.98532185
55VDR_23849224_ChIP-Seq_CD4+_Human1.95019419
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93172882
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.92010167
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91564685
59AR_21572438_ChIP-Seq_LNCaP_Human1.90468478
60MYB_26560356_Chip-Seq_TH1_Human1.88022851
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85812455
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84940809
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83338105
64SCL_19346495_ChIP-Seq_HPC-7_Human1.82149669
65SPI1_23127762_ChIP-Seq_K562_Human1.71686394
66GATA3_27048872_Chip-Seq_THYMUS_Human1.70314742
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68867570
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67721820
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60391306
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52570305
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50198445
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50043551
73IGF1R_20145208_ChIP-Seq_DFB_Human1.45065353
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.42738187
75FOXP3_21729870_ChIP-Seq_TREG_Human1.41699147
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41556757
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39422151
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.39026862
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36718685
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35751321
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31148317
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30672988
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.30302940
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.29963061
85ELK1_19687146_ChIP-ChIP_HELA_Human1.29509565
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28779679
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28317272
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26089072
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25852428
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25272669
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23520428
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22865999
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22775312
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22597232
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21689211
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21379411
97CTCF_27219007_Chip-Seq_Bcells_Human1.20846587
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.20819169
99MAF_26560356_Chip-Seq_TH1_Human1.20224172
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.19120894
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18412590
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16651894
103VDR_24787735_ChIP-Seq_THP-1_Human1.16124322
104UTX_26944678_Chip-Seq_JUKART_Human1.15901038
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15624381
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15069779
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14895713
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14767500
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14434721
110GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13234213
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13060317
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11424644
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09377456
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08975408
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08261615
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08170821
117BCAT_22108803_ChIP-Seq_LS180_Human1.08131562
118PU_27001747_Chip-Seq_BMDM_Mouse1.07817329
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07350462
120CIITA_25753668_ChIP-Seq_RAJI_Human1.07292739
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06832189
122SMAD4_21799915_ChIP-Seq_A2780_Human1.06742158
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06185466
124EGR1_19032775_ChIP-ChIP_M12_Human1.03317105
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03292701
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03094763
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02653298
128TFEB_21752829_ChIP-Seq_HELA_Human1.02317393
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00439335
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00400316
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99945439
132* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98897268
133ZNF274_21170338_ChIP-Seq_K562_Hela0.98797354
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98410324
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98230819
136KDM2B_26808549_Chip-Seq_K562_Human0.97890550
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.97537987
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96313285
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.96031078
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94539406
141MAF_26560356_Chip-Seq_TH2_Human0.94296839
142P300_19829295_ChIP-Seq_ESCs_Human0.94104758
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94078856
144KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93769348
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92960582
146MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92780055
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92286148
148STAT1_20625510_ChIP-Seq_HELA_Human0.91686062
149OCT4_19829295_ChIP-Seq_ESCs_Human0.91602650
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91342415
151AR_25329375_ChIP-Seq_VCAP_Human0.91333056
152SALL4_22934838_ChIP-ChIP_CD34+_Human0.91141349
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.90589587
154IRF1_19129219_ChIP-ChIP_H3396_Human0.90572162
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.90516774
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89815333
157PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89788440
158SMRT_27268052_Chip-Seq_Bcells_Human0.89371116
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.88937770
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87197248
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87171885
162FUS_26573619_Chip-Seq_HEK293_Human0.86942691
163CBX2_27304074_Chip-Seq_ESCs_Mouse0.86486971
164P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86408071
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.86210636
166VDR_24763502_ChIP-Seq_THP-1_Human0.86161224
167RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86116513
168GATA3_26560356_Chip-Seq_TH1_Human0.85938429
169PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85604832
170STAT3_23295773_ChIP-Seq_U87_Human0.85333239
171WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84836529
172HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84552187
173TP53_22573176_ChIP-Seq_HFKS_Human0.82228342
174EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81145839
175PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81081632
176HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80984449
177TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80969817
178KLF4_19829295_ChIP-Seq_ESCs_Human0.80611607
179* RBPJ_21746931_ChIP-Seq_IB4_Human0.80335780
180ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79566678
181PIAS1_25552417_ChIP-Seq_VCAP_Human0.79224017
182AR_19668381_ChIP-Seq_PC3_Human0.79105515
183MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78601028
184YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77848071
185VDR_22108803_ChIP-Seq_LS180_Human0.77666187
186SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77547553
187TP53_20018659_ChIP-ChIP_R1E_Mouse0.77430547
188VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77271531
189OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76812860
190ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76790609
191ELK1_22589737_ChIP-Seq_MCF10A_Human0.76737186
192* SMAD4_21741376_ChIP-Seq_ESCs_Human0.76703510
193TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75771380
194WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75289032
195SMAD3_21741376_ChIP-Seq_HESCs_Human0.73615939
196CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73391717
197SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72973085
198RXR_22158963_ChIP-Seq_LIVER_Mouse0.72681263
199CTCF_20526341_ChIP-Seq_ESCs_Human0.72568010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.69905244
2MP0001835_abnormal_antigen_presentation4.27207659
3MP0003724_increased_susceptibility_to4.19086781
4MP0005671_abnormal_response_to4.04656128
5MP0003303_peritoneal_inflammation3.63491841
6MP0004142_abnormal_muscle_tone3.51466397
7MP0009046_muscle_twitch3.48770456
8MP0003635_abnormal_synaptic_transmissio3.36065379
9MP0002332_abnormal_exercise_endurance3.35874026
10MP0003880_abnormal_central_pattern3.27597367
11MP0001800_abnormal_humoral_immune3.15675476
12MP0005387_immune_system_phenotype3.14536790
13MP0001790_abnormal_immune_system3.14536790
14MP0000751_myopathy3.11312686
15MP0005000_abnormal_immune_tolerance2.92869606
16MP0002064_seizures2.85068195
17MP0009745_abnormal_behavioral_response2.76086281
18MP0006082_CNS_inflammation2.74435402
19MP0002148_abnormal_hypersensitivity_rea2.68722329
20MP0005075_abnormal_melanosome_morpholog2.68015956
21MP0001853_heart_inflammation2.67569662
22MP0009785_altered_susceptibility_to2.64608827
23MP0002723_abnormal_immune_serum2.59829561
24MP0002234_abnormal_pharynx_morphology2.57207220
25MP0002452_abnormal_antigen_presenting2.54719896
26MP0000685_abnormal_immune_system2.52919881
27MP0003436_decreased_susceptibility_to2.52300929
28MP0002734_abnormal_mechanical_nocicepti2.44236061
29MP0002272_abnormal_nervous_system2.38727062
30MP0002420_abnormal_adaptive_immunity2.36962269
31MP0002184_abnormal_innervation2.35920402
32MP0001819_abnormal_immune_cell2.34254415
33MP0002419_abnormal_innate_immunity2.32693130
34MP0004381_abnormal_hair_follicle2.29682630
35MP0002063_abnormal_learning/memory/cond2.28681600
36MP0004036_abnormal_muscle_relaxation2.28084944
37MP0005025_abnormal_response_to2.25490226
38MP0000955_abnormal_spinal_cord2.25189061
39MP0003763_abnormal_thymus_physiology2.17554526
40MP0004484_altered_response_of2.10897625
41MP0002837_dystrophic_cardiac_calcinosis2.10012661
42MP0002269_muscular_atrophy2.07514768
43MP0009333_abnormal_splenocyte_physiolog2.07328933
44MP0004270_analgesia2.04534084
45MP0001486_abnormal_startle_reflex2.03608631
46MP0004215_abnormal_myocardial_fiber2.03544043
47MP0002166_altered_tumor_susceptibility1.92767644
48MP0001968_abnormal_touch/_nociception1.88016455
49MP0002067_abnormal_sensory_capabilities1.84049618
50MP0005464_abnormal_platelet_physiology1.83945193
51MP0002405_respiratory_system_inflammati1.80434053
52MP0005085_abnormal_gallbladder_physiolo1.79355296
53MP0000372_irregular_coat_pigmentation1.78083803
54MP0002398_abnormal_bone_marrow1.76351241
55MP0008569_lethality_at_weaning1.74400497
56MP0010155_abnormal_intestine_physiology1.72853053
57MP0000716_abnormal_immune_system1.72562999
58MP0001845_abnormal_inflammatory_respons1.70690665
59MP0002735_abnormal_chemical_nociception1.69781214
60MP0002254_reproductive_system_inflammat1.69620857
61MP0009764_decreased_sensitivity_to1.68154968
62MP0002572_abnormal_emotion/affect_behav1.66972749
63MP0010386_abnormal_urinary_bladder1.66301476
64MP0001970_abnormal_pain_threshold1.65196185
65MP0002909_abnormal_adrenal_gland1.62664677
66MP0001529_abnormal_vocalization1.56561467
67MP0002736_abnormal_nociception_after1.56245624
68MP0005551_abnormal_eye_electrophysiolog1.55203149
69MP0004084_abnormal_cardiac_muscle1.52631677
70MP0001873_stomach_inflammation1.47361428
71MP0000465_gastrointestinal_hemorrhage1.47014811
72MP0003329_amyloid_beta_deposits1.47009752
73MP0000689_abnormal_spleen_morphology1.46717067
74MP0005423_abnormal_somatic_nervous1.46709858
75MP0005310_abnormal_salivary_gland1.46698698
76MP0003866_abnormal_defecation1.46465788
77MP0002882_abnormal_neuron_morphology1.45533949
78MP0003172_abnormal_lysosome_physiology1.42643792
79MP0004510_myositis1.41452497
80MP0008469_abnormal_protein_level1.39664808
81MP0002429_abnormal_blood_cell1.39562882
82MP0000566_synostosis1.39527390
83MP0002006_tumorigenesis1.39392414
84MP0000569_abnormal_digit_pigmentation1.39128692
85MP0003879_abnormal_hair_cell1.37474708
86MP0004811_abnormal_neuron_physiology1.37223772
87MP0002229_neurodegeneration1.35097088
88MP0001851_eye_inflammation1.34503057
89MP0001533_abnormal_skeleton_physiology1.34427928
90MP0005266_abnormal_metabolism1.33548269
91MP0003075_altered_response_to1.32253583
92MP0004947_skin_inflammation1.30647002
93MP0005623_abnormal_meninges_morphology1.30550392
94MP0002557_abnormal_social/conspecific_i1.30007999
95MP0000015_abnormal_ear_pigmentation1.28962167
96MP0000759_abnormal_skeletal_muscle1.28934092
97MP0001501_abnormal_sleep_pattern1.28748974
98MP0004233_abnormal_muscle_weight1.28461560
99MP0002066_abnormal_motor_capabilities/c1.26875941
100MP0002733_abnormal_thermal_nociception1.26311739
101MP0002722_abnormal_immune_system1.25641743
102MP0008875_abnormal_xenobiotic_pharmacok1.23423579
103MP0001440_abnormal_grooming_behavior1.23146676
104MP0005174_abnormal_tail_pigmentation1.22315082
105MP0002277_abnormal_respiratory_mucosa1.21513501
106MP0000749_muscle_degeneration1.20782922
107MP0002752_abnormal_somatic_nervous1.18991425
108MP0005386_behavior/neurological_phenoty1.18983379
109MP0004924_abnormal_behavior1.18983379
110MP0006036_abnormal_mitochondrial_physio1.18465077
111MP0002139_abnormal_hepatobiliary_system1.18410913
112MP0002090_abnormal_vision1.17568088
113MP0005166_decreased_susceptibility_to1.16544523
114MP0005394_taste/olfaction_phenotype1.14355625
115MP0005499_abnormal_olfactory_system1.14355625
116MP0001984_abnormal_olfaction1.13799835
117MP0005360_urolithiasis1.13518117
118MP0006276_abnormal_autonomic_nervous1.13216970
119MP0002132_abnormal_respiratory_system1.12144480
120MP0000778_abnormal_nervous_system1.10736555
121MP0000703_abnormal_thymus_morphology1.10646297
122MP0002102_abnormal_ear_morphology1.08935623
123MP0002972_abnormal_cardiac_muscle1.07787078
124MP0004085_abnormal_heartbeat1.06413667
125MP0001177_atelectasis1.04728436
126MP0002396_abnormal_hematopoietic_system1.04033414
127MP0002163_abnormal_gland_morphology1.03972355
128MP0001502_abnormal_circadian_rhythm1.03507702
129MP0003633_abnormal_nervous_system1.03107949
130MP0005620_abnormal_muscle_contractility1.02365597
131MP0003300_gastrointestinal_ulcer0.98954996
132MP0009763_increased_sensitivity_to0.97288460
133MP0000747_muscle_weakness0.95494451
134MP0002138_abnormal_hepatobiliary_system0.94711242
135MP0005379_endocrine/exocrine_gland_phen0.93754388
136MP0001963_abnormal_hearing_physiology0.92968271
137MP0005367_renal/urinary_system_phenotyp0.91815998
138MP0000516_abnormal_urinary_system0.91815998
139MP0008775_abnormal_heart_ventricle0.91635586
140MP0008877_abnormal_DNA_methylation0.91469500
141MP0000858_altered_metastatic_potential0.90937212
142MP0004087_abnormal_muscle_fiber0.88450671
143MP0003787_abnormal_imprinting0.87918718
144MP0001663_abnormal_digestive_system0.87488627
145MP0003646_muscle_fatigue0.87238715
146MP0005397_hematopoietic_system_phenotyp0.87066789
147MP0001545_abnormal_hematopoietic_system0.87066789
148MP0008260_abnormal_autophagy0.86552023
149MP0000343_altered_response_to0.86152695
150MP0002876_abnormal_thyroid_physiology0.84254567
151MP0010329_abnormal_lipoprotein_level0.84118679
152MP0005451_abnormal_body_composition0.84004391
153MP0003122_maternal_imprinting0.83081365
154MP0006035_abnormal_mitochondrial_morpho0.82235195
155MP0000920_abnormal_myelination0.82058117
156MP0002796_impaired_skin_barrier0.81845438
157MP0003195_calcinosis0.81232436
158MP0003806_abnormal_nucleotide_metabolis0.81223441
159MP0005330_cardiomyopathy0.80198649
160MP0003252_abnormal_bile_duct0.80002405
161MP0003631_nervous_system_phenotype0.79558359
162MP0004043_abnormal_pH_regulation0.79490818
163MP0004858_abnormal_nervous_system0.78885987
164MP0002933_joint_inflammation0.77820285
165MP0003868_abnormal_feces_composition0.75501703
166MP0009840_abnormal_foam_cell0.73649470
167MP0004130_abnormal_muscle_cell0.73520902
168MP0003634_abnormal_glial_cell0.73403325
169MP0003137_abnormal_impulse_conducting0.73134072
170MP0001943_abnormal_respiration0.73025868
171MP0003948_abnormal_gas_homeostasis0.72866232
172MP0002693_abnormal_pancreas_physiology0.71997730
173MP0000534_abnormal_ureter_morphology0.71766808
174MP0006138_congestive_heart_failure0.71242021
175MP0008874_decreased_physiological_sensi0.71228594
176MP0001881_abnormal_mammary_gland0.70525869
177MP0002998_abnormal_bone_remodeling0.70214726
178MP0000609_abnormal_liver_physiology0.70188893
179MP0003448_altered_tumor_morphology0.68965177
180MP0001905_abnormal_dopamine_level0.67918286
181MP0001544_abnormal_cardiovascular_syste0.67121697
182MP0005535_abnormal_body_temperature0.66964839
183MP0003828_pulmonary_edema0.65146837
184MP0003453_abnormal_keratinocyte_physiol0.62092593
185MP0001919_abnormal_reproductive_system0.59853422
186MP0002095_abnormal_skin_pigmentation0.57496529
187MP0005410_abnormal_fertilization0.55919718
188MP0002136_abnormal_kidney_physiology0.55528747
189MP0000249_abnormal_blood_vessel0.53453523
190MP0005058_abnormal_lysosome_morphology0.52116070
191MP0005332_abnormal_amino_acid0.50899014
192MP0005365_abnormal_bile_salt0.50805919

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.79653382
23-Methylglutaconic aciduria (HP:0003535)4.55288319
3Acute necrotizing encephalopathy (HP:0006965)4.26156256
4Abnormality of the vocal cords (HP:0008777)4.17959965
5Abnormal mitochondria in muscle tissue (HP:0008316)3.99360553
6Megalencephaly (HP:0001355)3.97829647
7Pheochromocytoma (HP:0002666)3.97812776
8Progressive macrocephaly (HP:0004481)3.93787944
9Stomatitis (HP:0010280)3.93546427
10Elevated erythrocyte sedimentation rate (HP:0003565)3.86675473
11Absence seizures (HP:0002121)3.84879939
12Acute encephalopathy (HP:0006846)3.73240885
13Mediastinal lymphadenopathy (HP:0100721)3.69761629
14Mitochondrial inheritance (HP:0001427)3.64568130
15Supranuclear gaze palsy (HP:0000605)3.63976093
16Recurrent abscess formation (HP:0002722)3.61758886
17Atonic seizures (HP:0010819)3.59820678
18T lymphocytopenia (HP:0005403)3.59485671
19Myositis (HP:0100614)3.57229809
20Recurrent bacterial skin infections (HP:0005406)3.47486592
21Neuroendocrine neoplasm (HP:0100634)3.44803198
22Pulmonary infiltrates (HP:0002113)3.44323334
23Retrobulbar optic neuritis (HP:0100654)3.40507773
24Optic neuritis (HP:0100653)3.40507773
25Focal motor seizures (HP:0011153)3.31609918
26Abnormality of T cell number (HP:0011839)3.30808354
27Generalized tonic-clonic seizures (HP:0002069)3.30172919
28Febrile seizures (HP:0002373)3.29877377
29Chronic obstructive pulmonary disease (HP:0006510)3.26174028
30Obstructive lung disease (HP:0006536)3.26174028
31Hepatocellular necrosis (HP:0001404)3.24526562
32Progressive external ophthalmoplegia (HP:0000590)3.16090546
33Cerebral edema (HP:0002181)3.08860616
34Dialeptic seizures (HP:0011146)3.08787246
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.07119671
36Epileptic encephalopathy (HP:0200134)3.06437058
37Conjunctival hamartoma (HP:0100780)3.06358747
38Abnormality of macrophages (HP:0004311)3.03543338
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02294410
40Orchitis (HP:0100796)3.00318186
41Hepatic necrosis (HP:0002605)2.99913583
42Exercise-induced myalgia (HP:0003738)2.96637613
43Eczematoid dermatitis (HP:0000976)2.95061404
44Ketoacidosis (HP:0001993)2.92755964
45Recurrent fungal infections (HP:0002841)2.91300763
46Palpitations (HP:0001962)2.90259330
47Vasculitis (HP:0002633)2.90227645
48Muscle stiffness (HP:0003552)2.90044134
49Increased CSF lactate (HP:0002490)2.89778967
50Petechiae (HP:0000967)2.88514739
51Dysdiadochokinesis (HP:0002075)2.87020819
52Abnormality of liposaccharide metabolism (HP:0010968)2.86099526
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.86099526
54Abnormality of glycolipid metabolism (HP:0010969)2.86099526
55Increased cerebral lipofuscin (HP:0011813)2.84068952
56Hypoproteinemia (HP:0003075)2.83346083
57Recurrent cutaneous fungal infections (HP:0011370)2.81227072
58Chronic mucocutaneous candidiasis (HP:0002728)2.81227072
59Anxiety (HP:0000739)2.77701359
60Cerebellar dysplasia (HP:0007033)2.77291784
61Increased intramyocellular lipid droplets (HP:0012240)2.76657327
62Recurrent gram-negative bacterial infections (HP:0005420)2.76344091
63Spastic paraparesis (HP:0002313)2.75185750
64IgG deficiency (HP:0004315)2.73863129
65Episodic fever (HP:0001954)2.72085849
66Meningitis (HP:0001287)2.71720989
67Encephalitis (HP:0002383)2.70424111
68Poor suck (HP:0002033)2.69595090
69Alveolar cell carcinoma (HP:0006519)2.67115427
70Gastrointestinal infarctions (HP:0005244)2.64487595
71Congenital, generalized hypertrichosis (HP:0004540)2.64426044
72Severe combined immunodeficiency (HP:0004430)2.63635688
73Focal seizures (HP:0007359)2.61020144
74Sex reversal (HP:0012245)2.58576375
75Abnormal sex determination (HP:0012244)2.58576375
76Slow saccadic eye movements (HP:0000514)2.58406114
77Abnormality of T cells (HP:0002843)2.57482015
78Bundle branch block (HP:0011710)2.56805668
79Progressive cerebellar ataxia (HP:0002073)2.56667459
80Emotional lability (HP:0000712)2.55249489
81Hemoptysis (HP:0002105)2.53070557
82Recurrent skin infections (HP:0001581)2.51181855
83Optic disc pallor (HP:0000543)2.51178354
84Abnormality of the aortic arch (HP:0012303)2.51099824
85Neoplasm of the tracheobronchial system (HP:0100552)2.50677281
86Increased muscle lipid content (HP:0009058)2.48873440
87Chronic diarrhea (HP:0002028)2.48784148
88Leukodystrophy (HP:0002415)2.48747323
89Neoplasm of the peripheral nervous system (HP:0100007)2.46033445
90Sudden death (HP:0001699)2.45922932
91Exercise intolerance (HP:0003546)2.44810519
92Ventricular fibrillation (HP:0001663)2.44782596
93Adenoma sebaceum (HP:0009720)2.43894616
94Angiofibromas (HP:0010615)2.43894616
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43201749
96Atrial fibrillation (HP:0005110)2.41903396
97Respiratory failure (HP:0002878)2.40857615
98Chest pain (HP:0100749)2.40854156
99Depression (HP:0000716)2.40834440
100Action tremor (HP:0002345)2.40808665
101Gangrene (HP:0100758)2.39615848
102Keratoconjunctivitis (HP:0001096)2.38738392
103Autoimmune hemolytic anemia (HP:0001890)2.37115147
104Renal Fanconi syndrome (HP:0001994)2.36640880
105Keratoconjunctivitis sicca (HP:0001097)2.34936079
106Anhidrosis (HP:0000970)2.34050696
107Sensorimotor neuropathy (HP:0007141)2.33708243
108Pulmonary embolism (HP:0002204)2.33073943
109Abnormality of the prostate (HP:0008775)2.32435372
110Dysmetria (HP:0001310)2.32287273
111Limb-girdle muscle atrophy (HP:0003797)2.31497571
112Orthostatic hypotension (HP:0001278)2.30337615
113Ketosis (HP:0001946)2.29548957
114Ulnar claw (HP:0001178)2.28258146
115Partial agenesis of the corpus callosum (HP:0001338)2.26767894
116Skin nodule (HP:0200036)2.26443563
117Cerebral hemorrhage (HP:0001342)2.26319788
118Recurrent bronchitis (HP:0002837)2.26172750
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22775419
120Abnormality of alanine metabolism (HP:0010916)2.22775419
121Hyperalaninemia (HP:0003348)2.22775419
122Primary atrial arrhythmia (HP:0001692)2.21762050
123Abnormal delayed hypersensitivity skin test (HP:0002963)2.21012989
124Gingival bleeding (HP:0000225)2.20936623
125Panhypogammaglobulinemia (HP:0003139)2.20734367
126Increased serum pyruvate (HP:0003542)2.18909427
127Abnormality of glycolysis (HP:0004366)2.18909427
128Microretrognathia (HP:0000308)2.18228010
129Exertional dyspnea (HP:0002875)2.18077059
130Supraventricular tachycardia (HP:0004755)2.15204258
131Lactic acidosis (HP:0003128)2.14951153
132Thyroiditis (HP:0100646)2.13795041
133Combined immunodeficiency (HP:0005387)2.13600668
134Arterial thrombosis (HP:0004420)2.13352977
135Abnormal EKG (HP:0003115)2.12160286
136Abnormality of the pleura (HP:0002103)2.10998644
137Epistaxis (HP:0000421)2.10454825
138Hamartoma of the eye (HP:0010568)2.10322725
139Prolonged bleeding time (HP:0003010)2.10027547
140Epileptiform EEG discharges (HP:0011182)2.09817853
141Increased hepatocellular lipid droplets (HP:0006565)2.09067147
142Gonadal dysgenesis (HP:0000133)2.08324074
143Supraventricular arrhythmia (HP:0005115)2.08028916
144Torticollis (HP:0000473)2.07897328
145Pulmonary fibrosis (HP:0002206)2.07790990
146Abnormal spermatogenesis (HP:0008669)2.07191184
147Urticaria (HP:0001025)2.06587319
148Athetosis (HP:0002305)2.05863490
149Paraparesis (HP:0002385)2.05689547
150Anorexia (HP:0002039)2.04202943
151Syncope (HP:0001279)2.04129888
152Recurrent viral infections (HP:0004429)2.03892760
153Ankle clonus (HP:0011448)2.03840407
154Porencephaly (HP:0002132)2.02713209
155Abnormality of the axillary hair (HP:0100134)2.02619604
156Abnormality of secondary sexual hair (HP:0009888)2.02619604
157Increased CSF protein (HP:0002922)2.02547934
158Visual hallucinations (HP:0002367)2.01558118
159Inflammation of the large intestine (HP:0002037)2.00697394
160Amblyopia (HP:0000646)2.00303829
161Joint swelling (HP:0001386)2.00212949
162EEG with generalized epileptiform discharges (HP:0011198)2.00182707
163Lipid accumulation in hepatocytes (HP:0006561)1.99776551
164Status epilepticus (HP:0002133)1.98225777
165Foot dorsiflexor weakness (HP:0009027)1.97851150
166Global brain atrophy (HP:0002283)1.96925458
167Hypothermia (HP:0002045)1.96881229
168Arthropathy (HP:0003040)1.96804264
169Prolonged QT interval (HP:0001657)1.95607264
170IgM deficiency (HP:0002850)1.94837390
171Keratitis (HP:0000491)1.94824339
172Focal dystonia (HP:0004373)1.94248778
173Albinism (HP:0001022)1.93631565
174Micronodular cirrhosis (HP:0001413)1.91208104
175Exercise-induced muscle cramps (HP:0003710)1.89522559
176Cholelithiasis (HP:0001081)1.89046548
177Craniofacial dystonia (HP:0012179)1.87921470
178Dysmetric saccades (HP:0000641)1.87543954
179Urinary urgency (HP:0000012)1.86953149
180Asymmetric septal hypertrophy (HP:0001670)1.86768202
181EMG: myopathic abnormalities (HP:0003458)1.85877336
182Abnormality of the foot musculature (HP:0001436)1.85388724
183Slow progression (HP:0003677)1.82919204
184Abnormality of the calf musculature (HP:0001430)1.82877521
185Abnormal gallbladder morphology (HP:0012437)1.81988853
186Hypercortisolism (HP:0001578)1.81046718
187Myotonia (HP:0002486)1.80081923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.90547635
2BMPR24.81951040
3IRAK34.41781758
4MINK13.65280271
5MATK3.55593552
6NEK13.22767963
7RIPK43.16467108
8MAP4K13.16163092
9TAOK13.11496338
10MAP3K123.01961925
11TAOK22.98438147
12MARK12.75439732
13MAP3K32.52628363
14MAP3K92.48547033
15PAK62.34203739
16MAP2K32.27676162
17MAPKAPK32.21891525
18TAOK32.17728089
19CSK2.13421282
20LMTK22.12659375
21TXK2.11586189
22NLK2.07738981
23PAK32.01301832
24KSR21.98555927
25MAP3K41.86302446
26PHKG21.80837331
27PHKG11.80837331
28MAP2K71.79711284
29BLK1.79401115
30MAP2K41.76781320
31PKN21.72826197
32KIT1.69447280
33NTRK31.67081287
34LIMK11.66996381
35CDK191.66921424
36PRPF4B1.62352644
37GRK61.58990809
38NME11.58793358
39MAP3K141.55935884
40FRK1.53743839
41CSF1R1.51636836
42IKBKB1.49575591
43EPHA41.47692713
44CAMK2D1.47274434
45BTK1.45787132
46TLK11.44825942
47MAP3K131.41676188
48LYN1.40794305
49CAMK2G1.40794124
50NTRK11.40251794
51GRK71.36866272
52LCK1.34931181
53ZAP701.33530154
54JAK31.32890873
55NUAK11.32174348
56MAP3K111.31321570
57MAP3K51.29383117
58SYK1.29099127
59TYK21.28931354
60TEC1.27141173
61JAK11.25791789
62HCK1.24815002
63ITK1.24593212
64NTRK21.18718101
65WNK11.18250344
66IRAK21.15886609
67BCKDK1.10668727
68KSR11.10348630
69LATS21.07251197
70CAMKK11.05765297
71TTN1.05370869
72PINK11.02972435
73CSNK1G31.02721577
74MARK31.00583240
75MYLK1.00005833
76CSNK1A1L0.99771132
77PRKD30.99591937
78CAMK2A0.97143101
79PRKCG0.94324232
80CAMK2B0.89656673
81IKBKE0.88933713
82MAPK130.88930130
83GRK50.88586227
84ROCK20.85632307
85CSNK1G20.84217841
86CDK50.83894387
87IRAK10.83655455
88ARAF0.82757902
89FES0.82754935
90STK390.81318535
91TRIB30.81117913
92SIK30.80436113
93FER0.79461341
94STK380.78450391
95PLK20.74831814
96OBSCN0.73010424
97ALK0.72751161
98OXSR10.69394029
99PDPK10.67938007
100NME20.67542118
101CSNK1G10.67104522
102PRKCQ0.66851345
103TRPM70.65528428
104WNK40.65357307
105PDK10.64152759
106CDK140.63615632
107MAP2K10.62728073
108ADRBK20.60347736
109CDC42BPA0.60236082
110PRKCE0.60088526
111PRKG20.59976030
112PRKCZ0.58115494
113IRAK40.57258851
114RET0.57040861
115ERBB30.56265305
116TBK10.55279518
117YES10.54664270
118STK100.52713772
119UHMK10.52321691
120CAMK1D0.52084347
121MST40.51473657
122MAPKAPK20.51337238
123CDK150.49996024
124DAPK30.49027856
125MAP3K10.48790866
126DAPK20.48332500
127CDK180.48235564
128PIK3CG0.47956162
129PRKCH0.47870572
130IGF1R0.47192340
131CHUK0.46404312
132TNK20.43357175
133JAK20.42706806
134PTK2B0.42377299
135FYN0.42079051
136CAMK40.40220433
137ABL10.40177021
138GRK10.39466577
139ADRBK10.37669734
140CDK11A0.37615148
141ILK0.36641507
142SGK2230.35774273
143SGK4940.35774273
144ERBB20.35596563
145PKN10.35371457
146PRKACA0.34843660
147CAMK10.34828342
148MST1R0.34802891
149CAMK1G0.34361772
150PIM10.33241804
151PRKACB0.33024679
152EGFR0.32435879
153MOS0.32190706
154CAMKK20.31446979
155RIPK10.31060621
156DYRK1A0.30297007
157DAPK10.30123183
158FGR0.29149112
159MUSK0.28989796
160SCYL20.28463318
161RAF10.28049735
162MAP3K60.27457011
163PRKACG0.27089849
164LRRK20.26594106
165WNK30.26399797
166PRKCA0.26190606
167CSNK1E0.25384041
168ERBB40.25268848
169MAP2K60.22609428
170FLT30.22189663
171PRKG10.21875085
172INSR0.19559761
173CSNK2A10.19212620
174PAK10.16569635
175PRKCD0.13189231
176CDK40.12539046

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.85960244
2Allograft rejection_Homo sapiens_hsa053304.84402308
3Graft-versus-host disease_Homo sapiens_hsa053324.78930008
4Autoimmune thyroid disease_Homo sapiens_hsa053204.58569663
5Type I diabetes mellitus_Homo sapiens_hsa049404.23365421
6Oxidative phosphorylation_Homo sapiens_hsa001903.76062263
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.56310660
8Parkinsons disease_Homo sapiens_hsa050123.50822959
9Synaptic vesicle cycle_Homo sapiens_hsa047213.33322286
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.89447889
11Cardiac muscle contraction_Homo sapiens_hsa042602.79124534
12Alzheimers disease_Homo sapiens_hsa050102.73737755
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69753616
14Staphylococcus aureus infection_Homo sapiens_hsa051502.65773655
15Leishmaniasis_Homo sapiens_hsa051402.62779696
16Antigen processing and presentation_Homo sapiens_hsa046122.62562381
17Viral myocarditis_Homo sapiens_hsa054162.47084230
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46021597
19Huntingtons disease_Homo sapiens_hsa050162.25872715
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15621664
21Olfactory transduction_Homo sapiens_hsa047402.07856045
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05733074
23Cholinergic synapse_Homo sapiens_hsa047252.04386724
24Rheumatoid arthritis_Homo sapiens_hsa053232.00473987
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95984261
26Primary immunodeficiency_Homo sapiens_hsa053401.82511127
27Nicotine addiction_Homo sapiens_hsa050331.79619521
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78983352
29Hematopoietic cell lineage_Homo sapiens_hsa046401.78644883
30Propanoate metabolism_Homo sapiens_hsa006401.78466322
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77742957
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76776053
33GABAergic synapse_Homo sapiens_hsa047271.76416573
34Nitrogen metabolism_Homo sapiens_hsa009101.74094577
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71042482
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60843989
37Proteasome_Homo sapiens_hsa030501.59212723
38Circadian entrainment_Homo sapiens_hsa047131.54309542
39Pyruvate metabolism_Homo sapiens_hsa006201.49566312
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47331870
41Toxoplasmosis_Homo sapiens_hsa051451.45886489
42Herpes simplex infection_Homo sapiens_hsa051681.44563330
43Morphine addiction_Homo sapiens_hsa050321.44440052
44Tuberculosis_Homo sapiens_hsa051521.40716689
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38472358
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36833007
47Regulation of autophagy_Homo sapiens_hsa041401.36146071
48Taste transduction_Homo sapiens_hsa047421.35322413
49Insulin secretion_Homo sapiens_hsa049111.34621051
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33462821
51Long-term potentiation_Homo sapiens_hsa047201.32822823
52Butanoate metabolism_Homo sapiens_hsa006501.26862369
53Carbon metabolism_Homo sapiens_hsa012001.26612649
54Amphetamine addiction_Homo sapiens_hsa050311.24774252
55Dopaminergic synapse_Homo sapiens_hsa047281.24307466
56Glutamatergic synapse_Homo sapiens_hsa047241.23414549
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22890961
58T cell receptor signaling pathway_Homo sapiens_hsa046601.22546465
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21268966
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.19174698
61Salivary secretion_Homo sapiens_hsa049701.18148608
62Osteoclast differentiation_Homo sapiens_hsa043801.17614518
63Gastric acid secretion_Homo sapiens_hsa049711.14409725
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14302345
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14002532
66Ribosome_Homo sapiens_hsa030101.13231860
67Legionellosis_Homo sapiens_hsa051341.13037241
68Influenza A_Homo sapiens_hsa051641.05285044
69Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05046635
70Dilated cardiomyopathy_Homo sapiens_hsa054141.04332580
71Fatty acid elongation_Homo sapiens_hsa000621.03875236
72Phagosome_Homo sapiens_hsa041450.99978951
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98300111
74Malaria_Homo sapiens_hsa051440.98013278
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97514241
76Measles_Homo sapiens_hsa051620.97371636
77Fatty acid degradation_Homo sapiens_hsa000710.97275669
78Arginine biosynthesis_Homo sapiens_hsa002200.96918355
79Oxytocin signaling pathway_Homo sapiens_hsa049210.95073609
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93012640
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92880587
82Collecting duct acid secretion_Homo sapiens_hsa049660.92688360
83Chemokine signaling pathway_Homo sapiens_hsa040620.87845956
84B cell receptor signaling pathway_Homo sapiens_hsa046620.87738132
85Sulfur metabolism_Homo sapiens_hsa009200.87222538
86Protein export_Homo sapiens_hsa030600.86689753
87Biosynthesis of amino acids_Homo sapiens_hsa012300.86477140
88Fatty acid metabolism_Homo sapiens_hsa012120.86005219
89Gap junction_Homo sapiens_hsa045400.84659999
90Cocaine addiction_Homo sapiens_hsa050300.82520942
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82011478
92Renin secretion_Homo sapiens_hsa049240.81777290
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80280272
94One carbon pool by folate_Homo sapiens_hsa006700.77349744
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.75424104
96Epstein-Barr virus infection_Homo sapiens_hsa051690.75208806
97Glioma_Homo sapiens_hsa052140.75177380
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74304469
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73280516
100Calcium signaling pathway_Homo sapiens_hsa040200.73217220
101Vibrio cholerae infection_Homo sapiens_hsa051100.72820320
102cAMP signaling pathway_Homo sapiens_hsa040240.69225961
103Bile secretion_Homo sapiens_hsa049760.67484093
104Systemic lupus erythematosus_Homo sapiens_hsa053220.65709691
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.63407463
106GnRH signaling pathway_Homo sapiens_hsa049120.63084600
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61317793
108Axon guidance_Homo sapiens_hsa043600.59692105
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59582545
110Type II diabetes mellitus_Homo sapiens_hsa049300.58485710
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58101773
112Serotonergic synapse_Homo sapiens_hsa047260.56931817
113Pertussis_Homo sapiens_hsa051330.56697496
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56019497
115Platelet activation_Homo sapiens_hsa046110.55426970
116Salmonella infection_Homo sapiens_hsa051320.54821359
117PPAR signaling pathway_Homo sapiens_hsa033200.54257581
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.53912094
119Prion diseases_Homo sapiens_hsa050200.53743610
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52583350
121Glucagon signaling pathway_Homo sapiens_hsa049220.51584980
122beta-Alanine metabolism_Homo sapiens_hsa004100.51492473
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50874201
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50870461
125Phenylalanine metabolism_Homo sapiens_hsa003600.50753932
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50699994
127RNA degradation_Homo sapiens_hsa030180.50324568
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49861643
129Tryptophan metabolism_Homo sapiens_hsa003800.49695604
130Choline metabolism in cancer_Homo sapiens_hsa052310.49309672
131Estrogen signaling pathway_Homo sapiens_hsa049150.48693463
132ErbB signaling pathway_Homo sapiens_hsa040120.48586543
133TNF signaling pathway_Homo sapiens_hsa046680.48429623
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48277675
135African trypanosomiasis_Homo sapiens_hsa051430.48127556
136Homologous recombination_Homo sapiens_hsa034400.45997241
137Thyroid cancer_Homo sapiens_hsa052160.45257191
138Arginine and proline metabolism_Homo sapiens_hsa003300.43878002
139Lysosome_Homo sapiens_hsa041420.42755235
140Retinol metabolism_Homo sapiens_hsa008300.40474119
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40420339
142Spliceosome_Homo sapiens_hsa030400.38364286
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.36611778
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36401070
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35902408
146Linoleic acid metabolism_Homo sapiens_hsa005910.35442830
147Glycerolipid metabolism_Homo sapiens_hsa005610.35307919
148Ras signaling pathway_Homo sapiens_hsa040140.34853532
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34089484
150Chemical carcinogenesis_Homo sapiens_hsa052040.32967739
151RNA polymerase_Homo sapiens_hsa030200.32723811
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.31949389
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.31216337
154Melanoma_Homo sapiens_hsa052180.31135337
155HTLV-I infection_Homo sapiens_hsa051660.31115518
156Shigellosis_Homo sapiens_hsa051310.30660581
157Cysteine and methionine metabolism_Homo sapiens_hsa002700.30596030
158VEGF signaling pathway_Homo sapiens_hsa043700.30234077
159Peroxisome_Homo sapiens_hsa041460.30010427
160Acute myeloid leukemia_Homo sapiens_hsa052210.29463859
161Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28748765
162Purine metabolism_Homo sapiens_hsa002300.26919310
163Neurotrophin signaling pathway_Homo sapiens_hsa047220.26917024
164Circadian rhythm_Homo sapiens_hsa047100.26633864
165Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26398018
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.26303238
167Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26165830
168Dorso-ventral axis formation_Homo sapiens_hsa043200.26086216
169Fructose and mannose metabolism_Homo sapiens_hsa000510.25983748
170Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25977880
171Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25567292
172Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25379023
173Renal cell carcinoma_Homo sapiens_hsa052110.25177360
174Melanogenesis_Homo sapiens_hsa049160.24838783
175Glycerophospholipid metabolism_Homo sapiens_hsa005640.23834910
176Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23515568
177Apoptosis_Homo sapiens_hsa042100.23270782
178Caffeine metabolism_Homo sapiens_hsa002320.19155506
179Drug metabolism - other enzymes_Homo sapiens_hsa009830.16185375
180Glycosaminoglycan degradation_Homo sapiens_hsa005310.16142437
181Hepatitis B_Homo sapiens_hsa051610.16037770
182Arachidonic acid metabolism_Homo sapiens_hsa005900.14361684
183HIF-1 signaling pathway_Homo sapiens_hsa040660.13621067
184MAPK signaling pathway_Homo sapiens_hsa040100.12550529
185Endocytosis_Homo sapiens_hsa041440.08706440
186mRNA surveillance pathway_Homo sapiens_hsa030150.08302080

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