UTS2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of fibroblast migration (GO:0010763)7.71264474
2intermediate filament organization (GO:0045109)7.57297337
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.04508284
4negative regulation of heart rate (GO:0010459)6.93604226
5neuromuscular synaptic transmission (GO:0007274)6.72277917
6regulation of glomerular filtration (GO:0003093)6.21673055
7neurotransmitter secretion (GO:0007269)6.14125826
8energy coupled proton transport, down electrochemical gradient (GO:0015985)6.06511516
9ATP synthesis coupled proton transport (GO:0015986)6.06511516
10neuronal action potential propagation (GO:0019227)5.67400171
11neurotransmitter biosynthetic process (GO:0042136)5.66301736
12tryptophan catabolic process (GO:0006569)5.61034929
13indole-containing compound catabolic process (GO:0042436)5.61034929
14indolalkylamine catabolic process (GO:0046218)5.61034929
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.36813885
16indolalkylamine metabolic process (GO:0006586)5.23434835
17regulation of transmission of nerve impulse (GO:0051969)5.15844458
18kynurenine metabolic process (GO:0070189)5.10878216
19respiratory electron transport chain (GO:0022904)5.09541046
20tryptophan metabolic process (GO:0006568)5.01413183
21renal system process involved in regulation of blood volume (GO:0001977)4.96711435
22electron transport chain (GO:0022900)4.93168038
23axon cargo transport (GO:0008088)4.87780807
24respiratory system process (GO:0003016)4.84688508
25drug catabolic process (GO:0042737)4.80460470
26sequestering of actin monomers (GO:0042989)4.76068340
27regulation of activation of Janus kinase activity (GO:0010533)4.54801599
28synaptic vesicle maturation (GO:0016188)4.48036254
29exogenous drug catabolic process (GO:0042738)4.36443839
30intermediate filament cytoskeleton organization (GO:0045104)4.33290443
31synaptic transmission, cholinergic (GO:0007271)4.32900722
32oxidative demethylation (GO:0070989)4.29735514
33righting reflex (GO:0060013)4.27028572
34neurotransmitter metabolic process (GO:0042133)4.24631162
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.21726060
36intermediate filament-based process (GO:0045103)4.17069739
37neuromuscular process controlling posture (GO:0050884)4.14739907
38renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.13926686
39tachykinin receptor signaling pathway (GO:0007217)4.09415369
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05738621
41regulation of neurotransmitter levels (GO:0001505)4.03093654
42piRNA metabolic process (GO:0034587)4.02779423
43aromatic amino acid family catabolic process (GO:0009074)3.96242698
44indole-containing compound metabolic process (GO:0042430)3.92965803
45cell communication by electrical coupling (GO:0010644)3.87700114
46neurotransmitter transport (GO:0006836)3.87206491
47signal peptide processing (GO:0006465)3.84654826
48cilium or flagellum-dependent cell motility (GO:0001539)3.83939234
49amine catabolic process (GO:0009310)3.78441241
50cellular biogenic amine catabolic process (GO:0042402)3.78441241
51calcium-mediated signaling using intracellular calcium source (GO:0035584)3.75980604
52positive regulation of vesicle fusion (GO:0031340)3.74517186
53regulation of vesicle fusion (GO:0031338)3.74023208
54gamma-aminobutyric acid transport (GO:0015812)3.73658185
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68925350
56photoreceptor cell maintenance (GO:0045494)3.62857167
57benzene-containing compound metabolic process (GO:0042537)3.62247969
58ketone body metabolic process (GO:1902224)3.61614941
59cell migration in hindbrain (GO:0021535)3.60429289
60retinal cone cell development (GO:0046549)3.60307061
61reflex (GO:0060004)3.52459351
62regulation of circadian sleep/wake cycle (GO:0042749)3.50515050
63regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.50515050
64synaptic vesicle exocytosis (GO:0016079)3.50113508
65diaphragm development (GO:0060539)3.48611495
66glyoxylate metabolic process (GO:0046487)3.45871627
67regulation of short-term neuronal synaptic plasticity (GO:0048172)3.45617348
68omega-hydroxylase P450 pathway (GO:0097267)3.45264477
69ATP biosynthetic process (GO:0006754)3.45186041
70negative regulation of neurological system process (GO:0031645)3.44806590
71adult walking behavior (GO:0007628)3.44521299
72hydrogen ion transmembrane transport (GO:1902600)3.41652580
73aromatic amino acid family metabolic process (GO:0009072)3.41072199
74ATP hydrolysis coupled proton transport (GO:0015991)3.39684084
75energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.39684084
76monoubiquitinated protein deubiquitination (GO:0035520)3.39603285
77skeletal muscle organ development (GO:0060538)3.39528899
78xenobiotic catabolic process (GO:0042178)3.39485820
79flavonoid metabolic process (GO:0009812)3.38616215
80negative regulation of calcium ion transport into cytosol (GO:0010523)3.37614758
81detection of light stimulus involved in sensory perception (GO:0050962)3.36966758
82detection of light stimulus involved in visual perception (GO:0050908)3.36966758
83regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.36528390
84DNA methylation involved in gamete generation (GO:0043046)3.35167554
85startle response (GO:0001964)3.31705971
86behavioral response to ethanol (GO:0048149)3.30654228
87regulation of memory T cell differentiation (GO:0043380)3.30173565
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28341354
89serotonin metabolic process (GO:0042428)3.26278358
90signal release (GO:0023061)3.25079791
91regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.24266623
92lateral ventricle development (GO:0021670)3.22153452
93epoxygenase P450 pathway (GO:0019373)3.19767144
94sexual reproduction (GO:0019953)3.18956865
95multicellular organism reproduction (GO:0032504)3.18407659
96regulation of hippo signaling (GO:0035330)3.18394744
97chaperone-mediated protein transport (GO:0072321)3.17973320
98cellular ketone body metabolic process (GO:0046950)3.16348665
99regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.16264382
100response to nitrosative stress (GO:0051409)3.15667488
101fucose catabolic process (GO:0019317)3.15078924
102L-fucose metabolic process (GO:0042354)3.15078924
103L-fucose catabolic process (GO:0042355)3.15078924
104negative regulation of heart contraction (GO:0045822)3.14614175
105cellular response to sterol (GO:0036315)3.14228146
106axon extension involved in axon guidance (GO:0048846)3.14172471
107neuron projection extension involved in neuron projection guidance (GO:1902284)3.14172471
108positive regulation of collagen biosynthetic process (GO:0032967)3.14010149
109protein localization to synapse (GO:0035418)3.13261627
110positive regulation of heart rate (GO:0010460)3.11873844
111natural killer cell activation involved in immune response (GO:0002323)3.09094600
112primary amino compound metabolic process (GO:1901160)3.07143081
113neural tube formation (GO:0001841)3.06288388
114auditory receptor cell stereocilium organization (GO:0060088)3.05715461
115neuron cell-cell adhesion (GO:0007158)3.05634999
116regulation of acrosome reaction (GO:0060046)3.04412914
117bile acid biosynthetic process (GO:0006699)3.04326062
118regulation of synaptic vesicle exocytosis (GO:2000300)3.03667510
119positive regulation of circadian rhythm (GO:0042753)3.01412230
120regulation of renal sodium excretion (GO:0035813)3.00745134
121activation of protein kinase A activity (GO:0034199)3.00150075
122positive regulation of collagen metabolic process (GO:0010714)2.96901739
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96125999
124positive regulation of developmental pigmentation (GO:0048087)2.95660542
125regulation of sarcomere organization (GO:0060297)2.94949469
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94197749
127sulfation (GO:0051923)2.92825422
128negative regulation of mast cell activation (GO:0033004)2.92587354
129positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.90358866
130drug metabolic process (GO:0017144)2.90284040
131establishment of protein localization to Golgi (GO:0072600)2.89358402
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88937071
133protein K48-linked deubiquitination (GO:0071108)2.88747860
134negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.88520249
135purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88241999
136alkaloid metabolic process (GO:0009820)2.88067404
137diacylglycerol metabolic process (GO:0046339)2.88054035
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87880725
139substantia nigra development (GO:0021762)2.87591963
140sarcoplasmic reticulum calcium ion transport (GO:0070296)2.86893065
141protein-chromophore linkage (GO:0018298)2.85855173
142amino acid salvage (GO:0043102)2.85639223
143L-methionine salvage (GO:0071267)2.85639223
144L-methionine biosynthetic process (GO:0071265)2.85639223
145sphingoid metabolic process (GO:0046519)2.85621677
146regulation of cell communication by electrical coupling (GO:0010649)2.85440048
147glutamate secretion (GO:0014047)2.84376628
148regulation of collagen biosynthetic process (GO:0032965)2.84084475
149negative regulation of complement activation (GO:0045916)2.83366137
150circadian sleep/wake cycle process (GO:0022410)2.83212135
151NAD biosynthetic process (GO:0009435)2.83003786
152dopamine transport (GO:0015872)2.82240451
153behavioral response to nicotine (GO:0035095)2.81273212
154rhythmic behavior (GO:0007622)2.80642010
155purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80290832
156negative regulation of protein activation cascade (GO:2000258)2.79730526
157detection of mechanical stimulus involved in sensory perception (GO:0050974)2.77609442
158cytidine deamination (GO:0009972)2.77116539
159cytidine metabolic process (GO:0046087)2.77116539
160cytidine catabolic process (GO:0006216)2.77116539
161regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76830739
162UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76790786
163proton transport (GO:0015992)2.74310791
164histone H4-K12 acetylation (GO:0043983)2.73552779
165membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73502185
166regulation of fibroblast migration (GO:0010762)2.73016051
167positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.72334353
168cellular glucuronidation (GO:0052695)2.71636898
169response to misfolded protein (GO:0051788)2.71285634
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71025065
171regulation of pigment cell differentiation (GO:0050932)2.70477241
172protein K11-linked deubiquitination (GO:0035871)2.69998968
173regulation of immune response to tumor cell (GO:0002837)2.69437479
174regulation of response to tumor cell (GO:0002834)2.69437479
175positive regulation of response to tumor cell (GO:0002836)2.69437479
176sodium-independent organic anion transport (GO:0043252)2.66296999
177response to pheromone (GO:0019236)2.62689630
178inner ear receptor stereocilium organization (GO:0060122)2.58611834
179adaptation of signaling pathway (GO:0023058)2.57793839
180C4-dicarboxylate transport (GO:0015740)2.56918328
181cAMP catabolic process (GO:0006198)2.55707331
182bile acid metabolic process (GO:0008206)2.53651202
183uronic acid metabolic process (GO:0006063)2.53390243
184glucuronate metabolic process (GO:0019585)2.53390243
185methionine biosynthetic process (GO:0009086)2.52583390
186regulation of meiosis I (GO:0060631)2.52284737
187DNA double-strand break processing (GO:0000729)2.51572413
188phasic smooth muscle contraction (GO:0014821)2.50677423
189L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49402289
190cellular response to ethanol (GO:0071361)2.49295084
191platelet dense granule organization (GO:0060155)2.48990263
192dicarboxylic acid catabolic process (GO:0043649)2.48080265
193S-adenosylmethionine metabolic process (GO:0046500)2.47662311
194regulation of collateral sprouting (GO:0048670)2.46897981
195thyroid hormone metabolic process (GO:0042403)2.45760328
196negative regulation of systemic arterial blood pressure (GO:0003085)2.45728508
197interkinetic nuclear migration (GO:0022027)2.45706312
198neurofilament cytoskeleton organization (GO:0060052)14.5730889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67279346
2IKZF1_21737484_ChIP-ChIP_HCT116_Human4.53704030
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58601125
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.57545813
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.40229998
6JARID2_20075857_ChIP-Seq_MESCs_Mouse3.31970085
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21667858
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08985344
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse3.05521141
10EZH2_18974828_ChIP-Seq_MESCs_Mouse3.03125106
11RNF2_18974828_ChIP-Seq_MESCs_Mouse3.03125106
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.02465141
13VDR_22108803_ChIP-Seq_LS180_Human2.91556391
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.78818293
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.74433231
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66436193
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65255205
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.61898111
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59967179
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59350280
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55653518
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55471472
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46917726
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43994849
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42159367
26ESR1_15608294_ChIP-ChIP_MCF-7_Human2.40934496
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40911913
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24672067
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.19984898
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18281641
31GBX2_23144817_ChIP-Seq_PC3_Human2.14681494
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.14346085
33REST_21632747_ChIP-Seq_MESCs_Mouse2.12873943
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.09821046
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08855214
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04079117
37EED_16625203_ChIP-ChIP_MESCs_Mouse2.01074686
38ER_23166858_ChIP-Seq_MCF-7_Human1.99368385
39STAT3_23295773_ChIP-Seq_U87_Human1.97752300
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.97468235
41EWS_26573619_Chip-Seq_HEK293_Human1.89798273
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83980738
43FUS_26573619_Chip-Seq_HEK293_Human1.78977755
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77889402
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76214913
46TCF4_23295773_ChIP-Seq_U87_Human1.75969482
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72069415
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68231314
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66499665
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.61517571
51CBP_20019798_ChIP-Seq_JUKART_Human1.60340144
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60340144
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58010423
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.55100586
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54785944
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54710921
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.51782472
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50087286
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.49739599
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48640257
61TCF4_22108803_ChIP-Seq_LS180_Human1.46793511
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44433440
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41463043
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.40207994
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40177209
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40177209
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39984443
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38980954
69RUNX2_22187159_ChIP-Seq_PCA_Human1.38303389
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.37947150
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37554062
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36647654
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.36644664
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35470866
75NANOG_19829295_ChIP-Seq_ESCs_Human1.35236872
76SOX2_19829295_ChIP-Seq_ESCs_Human1.35236872
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.34405927
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31245709
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.31131192
80TP53_16413492_ChIP-PET_HCT116_Human1.31117130
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30217363
82DROSHA_22980978_ChIP-Seq_HELA_Human1.29908583
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29554795
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28641250
85CDX2_22108803_ChIP-Seq_LS180_Human1.25595723
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25388990
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25028910
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.24786516
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.23177043
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22449524
91IRF1_19129219_ChIP-ChIP_H3396_Human1.21815976
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.21161577
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20188023
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20084353
95RNF2_27304074_Chip-Seq_NSC_Mouse1.18938397
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18031069
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.17931835
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.15394026
99SMAD3_21741376_ChIP-Seq_HESCs_Human1.15306664
100OCT4_19829295_ChIP-Seq_ESCs_Human1.15042774
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14357109
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13804010
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13505219
104KDM2B_26808549_Chip-Seq_REH_Human1.11530075
105TP53_22573176_ChIP-Seq_HFKS_Human1.11088554
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10834959
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.10484374
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10337380
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09871638
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09655435
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08999147
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07998291
113P53_22387025_ChIP-Seq_ESCs_Mouse1.06951410
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.06688004
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06444300
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.05517526
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05517526
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05472086
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05214618
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04683091
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04334789
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.04263052
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04155760
124TP53_18474530_ChIP-ChIP_U2OS_Human1.04136628
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.04072169
126AHR_22903824_ChIP-Seq_MCF-7_Human1.03662116
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03468040
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02759373
129CTCF_27219007_Chip-Seq_Bcells_Human1.00532722
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00317974
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99975523
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99625641
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98662524
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95632071
135KDM2B_26808549_Chip-Seq_K562_Human0.95399775
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95006032
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94815999
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94675156
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90934705
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90697645
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90513195
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89971894
143SMAD4_21799915_ChIP-Seq_A2780_Human0.88554835
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87019929
145ZNF274_21170338_ChIP-Seq_K562_Hela0.85132689
146AR_25329375_ChIP-Seq_VCAP_Human0.85082638
147IGF1R_20145208_ChIP-Seq_DFB_Human0.84838474
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84130921
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83640056
150AR_21572438_ChIP-Seq_LNCaP_Human0.83478461
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81468943
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80835233
153P300_19829295_ChIP-Seq_ESCs_Human0.79894824
154CJUN_26792858_Chip-Seq_BT549_Human0.79541952
155TAF15_26573619_Chip-Seq_HEK293_Human0.79406769
156BCAT_22108803_ChIP-Seq_LS180_Human0.78646712
157OCT4_20526341_ChIP-Seq_ESCs_Human0.78388419
158PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77546369
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.77314971
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76982847
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73804405
162STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.73446956
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.73391192
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73075989
165BP1_19119308_ChIP-ChIP_Hs578T_Human0.72892197
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.72889748
167JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72045445
168SMAD3_21741376_ChIP-Seq_EPCs_Human0.69024289
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.68933874
170OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.68673497

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004142_abnormal_muscle_tone5.81534432
2MP0002332_abnormal_exercise_endurance4.96799237
3MP0003195_calcinosis4.50594916
4MP0005423_abnormal_somatic_nervous3.96091557
5MP0002184_abnormal_innervation3.73304876
6MP0004859_abnormal_synaptic_plasticity3.67227992
7MP0008057_abnormal_DNA_replication3.61583378
8MP0000955_abnormal_spinal_cord3.38767849
9MP0003635_abnormal_synaptic_transmissio3.02296089
10MP0000566_synostosis3.00784620
11MP0003880_abnormal_central_pattern2.93992724
12MP0002269_muscular_atrophy2.92669121
13MP0002734_abnormal_mechanical_nocicepti2.75415040
14MP0005085_abnormal_gallbladder_physiolo2.75067114
15MP0006276_abnormal_autonomic_nervous2.70009622
16MP0002138_abnormal_hepatobiliary_system2.66088700
17MP0005551_abnormal_eye_electrophysiolog2.62869229
18MP0005623_abnormal_meninges_morphology2.62807133
19MP0000569_abnormal_digit_pigmentation2.54438772
20MP0003646_muscle_fatigue2.41640323
21MP0009745_abnormal_behavioral_response2.35717450
22MP0004270_analgesia2.29981487
23MP0008877_abnormal_DNA_methylation2.29189495
24MP0002735_abnormal_chemical_nociception2.24127429
25MP0008875_abnormal_xenobiotic_pharmacok2.22678665
26MP0002272_abnormal_nervous_system2.22256324
27MP0003252_abnormal_bile_duct2.18163608
28MP0009046_muscle_twitch2.15363723
29MP0003950_abnormal_plasma_membrane2.11917998
30MP0001348_abnormal_lacrimal_gland2.10714433
31MP0002064_seizures2.08113165
32MP0000427_abnormal_hair_cycle2.04809208
33MP0002139_abnormal_hepatobiliary_system2.01252548
34MP0003136_yellow_coat_color2.01210764
35MP0004043_abnormal_pH_regulation1.99544541
36MP0003329_amyloid_beta_deposits1.90221537
37MP0002102_abnormal_ear_morphology1.89314399
38MP0000534_abnormal_ureter_morphology1.85791079
39MP0001529_abnormal_vocalization1.84954444
40MP0001970_abnormal_pain_threshold1.84395694
41MP0002063_abnormal_learning/memory/cond1.81801342
42MP0008872_abnormal_physiological_respon1.81605318
43MP0000751_myopathy1.78009253
44MP0005266_abnormal_metabolism1.76550737
45MP0005253_abnormal_eye_physiology1.73235088
46MP0005365_abnormal_bile_salt1.72301771
47MP0009697_abnormal_copulation1.72035572
48MP0005670_abnormal_white_adipose1.70451837
49MP0005360_urolithiasis1.65421997
50MP0000383_abnormal_hair_follicle1.59575302
51MP0002882_abnormal_neuron_morphology1.59187057
52MP0004811_abnormal_neuron_physiology1.56710245
53MP0002752_abnormal_somatic_nervous1.54179030
54MP0001968_abnormal_touch/_nociception1.53097348
55MP0003122_maternal_imprinting1.52547563
56MP0005646_abnormal_pituitary_gland1.49991371
57MP0000759_abnormal_skeletal_muscle1.47289628
58MP0001486_abnormal_startle_reflex1.46218727
59MP0002254_reproductive_system_inflammat1.45093614
60MP0003948_abnormal_gas_homeostasis1.44922682
61MP0002733_abnormal_thermal_nociception1.43535056
62MP0001485_abnormal_pinna_reflex1.43136462
63MP0000372_irregular_coat_pigmentation1.41431782
64MP0003890_abnormal_embryonic-extraembry1.38163022
65MP0001984_abnormal_olfaction1.36387755
66MP0002557_abnormal_social/conspecific_i1.35975098
67MP0010329_abnormal_lipoprotein_level1.35434933
68MP0000749_muscle_degeneration1.33792033
69MP0005395_other_phenotype1.30749421
70MP0009765_abnormal_xenobiotic_induced1.29987639
71MP0001764_abnormal_homeostasis1.29102597
72MP0004510_myositis1.27770337
73MP0002638_abnormal_pupillary_reflex1.27726009
74MP0004147_increased_porphyrin_level1.23261138
75MP0006054_spinal_hemorrhage1.22725155
76MP0001299_abnormal_eye_distance/1.22437474
77MP0005410_abnormal_fertilization1.21945046
78MP0003868_abnormal_feces_composition1.21451588
79MP0005171_absent_coat_pigmentation1.20906698
80MP0005167_abnormal_blood-brain_barrier1.16564569
81MP0002572_abnormal_emotion/affect_behav1.15904199
82MP0002168_other_aberrant_phenotype1.14742292
83MP0000778_abnormal_nervous_system1.14389278
84MP0004145_abnormal_muscle_electrophysio1.12918660
85MP0001986_abnormal_taste_sensitivity1.12358476
86MP0003045_fibrosis1.12339247
87MP0002067_abnormal_sensory_capabilities1.10767276
88MP0003879_abnormal_hair_cell1.10564121
89MP0002066_abnormal_motor_capabilities/c1.10390530
90MP0003942_abnormal_urinary_system1.08893531
91MP0000604_amyloidosis1.08732377
92MP0004215_abnormal_myocardial_fiber1.08714767
93MP0002736_abnormal_nociception_after1.08256464
94MP0005645_abnormal_hypothalamus_physiol1.07580441
95MP0005386_behavior/neurological_phenoty1.06406911
96MP0004924_abnormal_behavior1.06406911
97MP0002938_white_spotting1.06222814
98MP0005647_abnormal_sex_gland1.06027749
99MP0008775_abnormal_heart_ventricle1.04813557
100MP0002229_neurodegeneration1.04160818
101MP0008058_abnormal_DNA_repair1.03124294
102MP0002837_dystrophic_cardiac_calcinosis1.02992317
103MP0000230_abnormal_systemic_arterial1.02748918
104MP0002282_abnormal_trachea_morphology1.02638539
105MP0001177_atelectasis1.01116231
106MP0004858_abnormal_nervous_system0.99799477
107MP0003633_abnormal_nervous_system0.99710366
108MP0006072_abnormal_retinal_apoptosis0.99547177
109MP0005332_abnormal_amino_acid0.97286236
110MP0008569_lethality_at_weaning0.97260235
111MP0002653_abnormal_ependyma_morphology0.96986899
112MP0001346_abnormal_lacrimal_gland0.96867213
113MP0006292_abnormal_olfactory_placode0.96464257
114MP0003698_abnormal_male_reproductive0.96427873
115MP0000538_abnormal_urinary_bladder0.96376892
116MP0005451_abnormal_body_composition0.94113970
117MP0003283_abnormal_digestive_organ0.93965193
118MP0001943_abnormal_respiration0.93491583
119MP0003221_abnormal_cardiomyocyte_apopto0.90656713
120MP0002277_abnormal_respiratory_mucosa0.90123467
121MP0004742_abnormal_vestibular_system0.88654044
122MP0002249_abnormal_larynx_morphology0.86599317
123MP0010386_abnormal_urinary_bladder0.84843010
124MP0001666_abnormal_nutrient_absorption0.84721150
125MP0003279_aneurysm0.84224317
126MP0001929_abnormal_gametogenesis0.84056614
127MP0005377_hearing/vestibular/ear_phenot0.83778480
128MP0003878_abnormal_ear_physiology0.83778480
129MP0002972_abnormal_cardiac_muscle0.83331467
130MP0001501_abnormal_sleep_pattern0.82214662
131MP0002928_abnormal_bile_duct0.81937521
132MP0010368_abnormal_lymphatic_system0.81893963
133MP0003718_maternal_effect0.81853736
134MP0005620_abnormal_muscle_contractility0.81586286
135MP0005195_abnormal_posterior_eye0.81447354
136MP0010678_abnormal_skin_adnexa0.79016353
137MP0001440_abnormal_grooming_behavior0.78627125
138MP0002909_abnormal_adrenal_gland0.78084891
139MP0000631_abnormal_neuroendocrine_gland0.77879569
140MP0005174_abnormal_tail_pigmentation0.76540710
141MP0002114_abnormal_axial_skeleton0.75923219
142MP0001502_abnormal_circadian_rhythm0.75833162
143MP0002090_abnormal_vision0.74706305
144MP0005187_abnormal_penis_morphology0.74234715
145MP0004036_abnormal_muscle_relaxation0.72804948
146MP0002751_abnormal_autonomic_nervous0.72131361
147MP0002876_abnormal_thyroid_physiology0.70942220
148MP0004085_abnormal_heartbeat0.69967449
149MP0001905_abnormal_dopamine_level0.68255363
150MP0005369_muscle_phenotype0.67226161
151MP0009250_abnormal_appendicular_skeleto0.65440629
152MP0002295_abnormal_pulmonary_circulatio0.63268358
153MP0005376_homeostasis/metabolism_phenot0.62517935
154MP0004084_abnormal_cardiac_muscle0.60330874
155MP0003385_abnormal_body_wall0.60267399
156MP0004087_abnormal_muscle_fiber0.59433865
157MP0000462_abnormal_digestive_system0.58253716
158MP0001963_abnormal_hearing_physiology0.57759547
159MP0004484_altered_response_of0.57735975
160MP0002081_perinatal_lethality0.56655720
161MP0002106_abnormal_muscle_physiology0.53193598
162MP0003634_abnormal_glial_cell0.52510784
163MP0003137_abnormal_impulse_conducting0.51864738
164MP0003091_abnormal_cell_migration0.50012417
165MP0003861_abnormal_nervous_system0.49447666

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the vocal cords (HP:0008777)6.13762846
2Myokymia (HP:0002411)5.85797651
3Poor suck (HP:0002033)5.30254032
4Ulnar claw (HP:0001178)5.07077779
5Pheochromocytoma (HP:0002666)4.83410445
6Pancreatic cysts (HP:0001737)4.47292811
7Neuroendocrine neoplasm (HP:0100634)4.39351257
8Progressive external ophthalmoplegia (HP:0000590)4.36193252
9Hyperventilation (HP:0002883)4.21639095
10Supranuclear gaze palsy (HP:0000605)4.03991815
11Pancreatic fibrosis (HP:0100732)3.91859513
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.91320244
13Acute necrotizing encephalopathy (HP:0006965)3.84961337
14Gaze-evoked nystagmus (HP:0000640)3.75129445
15Hypokinesia (HP:0002375)3.74267567
16Attenuation of retinal blood vessels (HP:0007843)3.70434245
17Septate vagina (HP:0001153)3.68442804
18True hermaphroditism (HP:0010459)3.65969053
19Type 2 muscle fiber atrophy (HP:0003554)3.65323167
20Mitochondrial inheritance (HP:0001427)3.44583869
21Fair hair (HP:0002286)3.42852787
22Abnormal mitochondria in muscle tissue (HP:0008316)3.40032883
23Renal Fanconi syndrome (HP:0001994)3.39498419
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33874025
25Genetic anticipation (HP:0003743)3.33097212
26Abnormality of the neuromuscular junction (HP:0003398)3.33010358
27Fatigable weakness (HP:0003473)3.33010358
28Generalized hypotonia (HP:0001290)3.32400061
29Progressive macrocephaly (HP:0004481)3.29639434
30Neoplasm of the peripheral nervous system (HP:0100007)3.23470789
31Acute encephalopathy (HP:0006846)3.19751915
32Abolished electroretinogram (ERG) (HP:0000550)3.19193384
33Molar tooth sign on MRI (HP:0002419)3.13881570
34Abnormality of midbrain morphology (HP:0002418)3.13881570
35Hypercortisolism (HP:0001578)3.11249629
36Segmental peripheral demyelination/remyelination (HP:0003481)3.09074201
37Muscle fiber atrophy (HP:0100295)3.07294368
38Aplasia/Hypoplasia of the tibia (HP:0005772)3.06936436
39Increased hepatocellular lipid droplets (HP:0006565)3.04004821
40Bony spicule pigmentary retinopathy (HP:0007737)3.03775701
41Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03096678
42Hyperphosphaturia (HP:0003109)3.03065287
43Hepatocellular necrosis (HP:0001404)2.98329836
44Chronic hepatic failure (HP:0100626)2.94802696
45Congenital stationary night blindness (HP:0007642)2.93112497
46Muscle stiffness (HP:0003552)2.91309970
47Nephronophthisis (HP:0000090)2.90876543
48Congenital sensorineural hearing impairment (HP:0008527)2.90792928
49Increased CSF lactate (HP:0002490)2.89868211
50Medial flaring of the eyebrow (HP:0010747)2.85515733
51Cystic liver disease (HP:0006706)2.82392747
52Clumsiness (HP:0002312)2.80686304
53Bicornuate uterus (HP:0000813)2.80597871
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79940740
55Abnormality of alanine metabolism (HP:0010916)2.79940740
56Hyperalaninemia (HP:0003348)2.79940740
57Myotonia (HP:0002486)2.77702185
58Abnormality of the renal cortex (HP:0011035)2.76790054
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.74012356
60Cerebral hemorrhage (HP:0001342)2.72021718
61Abnormality of the renal medulla (HP:0100957)2.71225941
62Conjunctival hamartoma (HP:0100780)2.69624641
63Rectal fistula (HP:0100590)2.68901685
64Rectovaginal fistula (HP:0000143)2.68901685
65Lipid accumulation in hepatocytes (HP:0006561)2.68584616
66Calcaneovalgus deformity (HP:0001848)2.68147456
67Absent speech (HP:0001344)2.66036624
68Sudden death (HP:0001699)2.62691918
69Focal motor seizures (HP:0011153)2.62585543
70Abnormality of calcium-phosphate metabolism (HP:0100530)2.58958723
71Foot dorsiflexor weakness (HP:0009027)2.57036453
72Diminished movement (HP:0002374)2.56806989
73Bile duct proliferation (HP:0001408)2.56686338
74Abnormal biliary tract physiology (HP:0012439)2.56686338
75Type II lissencephaly (HP:0007260)2.56375221
76Increased corneal curvature (HP:0100692)2.54813352
77Keratoconus (HP:0000563)2.54813352
78Central scotoma (HP:0000603)2.52626808
79Protruding tongue (HP:0010808)2.51178451
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.49697479
81Generalized hypopigmentation of hair (HP:0011358)2.49568878
82Bulbar palsy (HP:0001283)2.47863216
83Abnormal urine phosphate concentration (HP:0012599)2.47333544
84Congenital primary aphakia (HP:0007707)2.47297913
85Gait imbalance (HP:0002141)2.47251664
86Weak cry (HP:0001612)2.46986135
87Atonic seizures (HP:0010819)2.46243505
88Pendular nystagmus (HP:0012043)2.45940551
89Hammertoe (HP:0001765)2.44276978
90Steppage gait (HP:0003376)2.40040319
91Decreased circulating renin level (HP:0003351)2.38880352
92Hepatic necrosis (HP:0002605)2.37865617
93Furrowed tongue (HP:0000221)2.37047830
94Genital tract atresia (HP:0001827)2.35934597
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34883139
96Inability to walk (HP:0002540)2.30726507
97Deformed tarsal bones (HP:0008119)2.30618427
98Prolonged partial thromboplastin time (HP:0003645)2.28236263
99Abnormality of the foot musculature (HP:0001436)2.27748170
100Decreased motor nerve conduction velocity (HP:0003431)2.25770143
101Slow saccadic eye movements (HP:0000514)2.24994481
102Osteomalacia (HP:0002749)2.24992065
103Vaginal fistula (HP:0004320)2.24568441
104Abnormality of the corticospinal tract (HP:0002492)2.24390121
105Tubular atrophy (HP:0000092)2.23868550
106Failure to thrive in infancy (HP:0001531)2.23557648
107Hypothermia (HP:0002045)2.21970235
108Decreased central vision (HP:0007663)2.21741901
109Retinal dysplasia (HP:0007973)2.21042147
110Cerebral edema (HP:0002181)2.18484949
111Sclerocornea (HP:0000647)2.17462825
112Synostosis involving the elbow (HP:0003938)2.17212784
113Humeroradial synostosis (HP:0003041)2.17212784
114Cerebellar dysplasia (HP:0007033)2.16046283
115Vaginal atresia (HP:0000148)2.16003101
116Palpitations (HP:0001962)2.15710105
117Intestinal fistula (HP:0100819)2.15444871
118Proximal tubulopathy (HP:0000114)2.15214133
119Frequent falls (HP:0002359)2.15175093
120Facial diplegia (HP:0001349)2.14851144
121Buphthalmos (HP:0000557)2.14749223
122Abnormality of macular pigmentation (HP:0008002)2.14436210
123Onion bulb formation (HP:0003383)2.14399393
124Exercise intolerance (HP:0003546)2.14279204
125Nephrogenic diabetes insipidus (HP:0009806)2.14046762
126Broad-based gait (HP:0002136)2.13897647
127Recurrent bacterial skin infections (HP:0005406)2.13024269
128Progressive inability to walk (HP:0002505)2.11917423
129Progressive muscle weakness (HP:0003323)2.09572185
130Dialeptic seizures (HP:0011146)2.08245609
131Respiratory distress (HP:0002098)2.07050629
132Hypoplastic ischia (HP:0003175)2.06868604
133Anxiety (HP:0000739)2.06608188
134Respiratory failure (HP:0002878)2.06228076
135Ventricular fibrillation (HP:0001663)2.05660128
136Respiratory insufficiency due to muscle weakness (HP:0002747)2.05088739
137Chorioretinal atrophy (HP:0000533)2.03550387
138Small hand (HP:0200055)2.01585234
139Congenital hepatic fibrosis (HP:0002612)2.01114231
140Febrile seizures (HP:0002373)2.00880092
141Absence seizures (HP:0002121)1.99950819
142Thyroid-stimulating hormone excess (HP:0002925)1.99354633
143Megalencephaly (HP:0001355)1.99198035
144Scotoma (HP:0000575)1.98515754
145Distal sensory impairment (HP:0002936)1.98343123
146Hypertensive crisis (HP:0100735)1.96920523
147Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.96049416
148Hypoplastic labia majora (HP:0000059)1.95680830
149Leukodystrophy (HP:0002415)1.95516786
150Abnormal drinking behavior (HP:0030082)1.95163750
151Polydipsia (HP:0001959)1.95163750
152Short foot (HP:0001773)1.95052955
153Amelogenesis imperfecta (HP:0000705)1.93779127
154Hypophosphatemic rickets (HP:0004912)1.93101709
155Lissencephaly (HP:0001339)1.93066260
156Retinitis pigmentosa (HP:0000510)1.92109641
157Optic disc pallor (HP:0000543)1.91362181
158Emotional lability (HP:0000712)1.90438326
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90020007
160Abnormality of renal resorption (HP:0011038)1.89700994
161Birth length less than 3rd percentile (HP:0003561)1.89091713
162Abnormality of the ischium (HP:0003174)1.88911936
163Macular degeneration (HP:0000608)1.88648039
164Abnormal protein glycosylation (HP:0012346)1.88295866
165Abnormal glycosylation (HP:0012345)1.88295866
166Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88295866
167Abnormal protein N-linked glycosylation (HP:0012347)1.88295866
168Exertional dyspnea (HP:0002875)1.88214880
169Abnormal ciliary motility (HP:0012262)1.88102570
170Lactic acidosis (HP:0003128)1.87470074
171Generalized aminoaciduria (HP:0002909)1.87298092
172Progressive cerebellar ataxia (HP:0002073)1.86881990
173Optic nerve hypoplasia (HP:0000609)1.86682197
174Intrahepatic cholestasis (HP:0001406)1.86667954
175Insidious onset (HP:0003587)1.84956593
176Termporal pattern (HP:0011008)1.84956593
177Cavernous hemangioma (HP:0001048)1.83729937
178Stomach cancer (HP:0012126)1.83553229
179Aplasia/Hypoplasia of the fovea (HP:0008060)1.83426069
180Hypoplasia of the fovea (HP:0007750)1.83426069
181Postaxial foot polydactyly (HP:0001830)1.83213281
182Abnormality of glycolysis (HP:0004366)1.83200008
183Increased serum pyruvate (HP:0003542)1.83200008
184Focal seizures (HP:0007359)1.83029246
185Widely spaced teeth (HP:0000687)1.82918819
186External ophthalmoplegia (HP:0000544)1.82362580
187Large for gestational age (HP:0001520)1.81542728
188Delayed gross motor development (HP:0002194)1.81296525
189Adenoma sebaceum (HP:0009720)1.80097851
190Angiofibromas (HP:0010615)1.80097851
191Renal cortical cysts (HP:0000803)1.79864189
192Hyperlipoproteinemia (HP:0010980)1.77819241
193Poor coordination (HP:0002370)1.77815249
194Tubulointerstitial nephritis (HP:0001970)1.76136191
195Abnormality of the labia majora (HP:0012881)1.75877507
196Preaxial foot polydactyly (HP:0001841)1.75592912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.18332529
2MARK16.44057536
3MINK15.97778716
4IRAK34.49121387
5MAP3K123.68052646
6ACVR1B3.45546265
7LIMK13.17539170
8ADRBK23.07071526
9BMPR1B3.07054644
10MAP4K23.02840456
11INSRR2.69323890
12MAP3K92.52873851
13GRK12.40857988
14WNK32.37022850
15IRAK12.12663434
16OBSCN2.08907104
17IRAK41.96076793
18NEK11.94967583
19LATS21.93876859
20MAP3K41.92072566
21LATS11.90818570
22MAP2K41.89406538
23IRAK21.85566508
24TAOK31.83765657
25NME11.76963774
26NTRK31.76556203
27LMTK21.74777732
28CAMK2G1.74573029
29NUAK11.73020196
30CASK1.67693759
31PIK3CG1.65773843
32SCYL21.59295607
33PLK41.56504647
34KSR21.49891276
35PHKG11.46478142
36PHKG21.46478142
37BRSK21.45634853
38MAP3K111.45043088
39OXSR11.42937409
40PAK31.41939912
41GRK71.38160444
42ZAK1.31443787
43WNK11.30525599
44MAP2K71.25786962
45PAK61.25706815
46PRKCG1.25694535
47MAPK131.25295000
48STK391.25071504
49TGFBR11.18851921
50MYLK1.17699077
51TESK11.15343400
52NTRK11.14982956
53TRIM281.12545336
54GRK51.11789166
55MKNK21.09270714
56PTK2B1.07298333
57PINK11.06793777
58TESK21.05983291
59TEC1.05273071
60CAMK2A1.01931804
61TIE11.01301972
62STK30.99613017
63CDC42BPA0.98403998
64EPHA30.96730618
65RET0.93378732
66NLK0.91815838
67WNK40.90405414
68KSR10.90290061
69EPHB20.88580025
70PRKCE0.88185335
71TXK0.87460777
72PRKCZ0.85868742
73PRKCI0.83029346
74PLK20.79285377
75ERBB40.79270094
76MELK0.78603625
77CAMK2D0.78561024
78BCR0.78483975
79MAP3K60.78012454
80CAMK2B0.76714999
81PRKAA20.76364481
82PIK3CA0.73492066
83TNK20.72904186
84CSNK1A1L0.71670291
85CSNK1G10.71068643
86STK240.70806363
87ROCK20.70473920
88AKT30.69910031
89STK38L0.66402795
90CDK50.65583267
91PKN10.64654680
92CSNK1G20.64606808
93CDK140.64423077
94TNIK0.63992939
95NTRK20.62708829
96ADRBK10.62540623
97EPHA40.61363248
98ROCK10.56750444
99CDK180.56712588
100CDK30.56692942
101KIT0.56372103
102CDK150.56080599
103EIF2AK30.55489115
104CSNK1G30.54356972
105PRKAA10.53476327
106ARAF0.53354055
107MATK0.50853473
108DAPK20.49948904
109PTK20.49843464
110MARK30.49727103
111CDK190.49601551
112MAP3K70.48519377
113CAMKK10.48310518
114DYRK20.47381118
115EPHB10.45755845
116MAP3K130.45598759
117PRKCH0.45576117
118SGK20.45142216
119CDK11A0.45048893
120CSNK1A10.44642749
121CSNK1E0.44514513
122CSNK1D0.44010315
123CHEK20.43606165
124UHMK10.40890190
125STK160.40688356
126MAP2K10.40120255
127MKNK10.39957829
128PRKG10.38704899
129FER0.37951788
130FGFR20.37487268
131PBK0.36896871
132ERBB20.36258103
133ALK0.35556144
134CAMK40.35313681
135ERBB30.34969319
136MAP3K10.34136581
137MAPK40.33444748
138TTN0.32462393
139ATM0.31948509
140STK380.30105623
141CAMK10.29490299
142IGF1R0.28720498
143PRKCD0.28403665
144ABL10.27911904
145PRKACA0.27829696
146FLT30.27539102
147CAMKK20.27323637
148PDK20.27303445
149CAMK1G0.26597118
150PRKACG0.26531253
151PRKD30.25643994
152CHUK0.25609185
153MAP3K20.25214097
154ITK0.24862275
155YES10.24717349
156MAPK80.24607395
157MAPK70.23446203
158PLK10.23420211
159ABL20.23322805
160RAF10.23211594
161PRKCB0.22673885
162DAPK30.19579918
163PRKCA0.17939140
164PRKACB0.16873986
165EGFR0.15646908
166MUSK0.15561516
167MAP3K140.15148707
168RPS6KA20.14594061

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.02116438
2Parkinsons disease_Homo sapiens_hsa050124.53359813
3Synaptic vesicle cycle_Homo sapiens_hsa047214.06748591
4Alzheimers disease_Homo sapiens_hsa050103.36602956
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.32751480
6Huntingtons disease_Homo sapiens_hsa050163.05879190
7Cardiac muscle contraction_Homo sapiens_hsa042603.02404636
8Cholinergic synapse_Homo sapiens_hsa047252.84232854
9Caffeine metabolism_Homo sapiens_hsa002322.78538570
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.72153922
11Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.71865620
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.70362253
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.67215628
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52048380
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.49664307
16Tryptophan metabolism_Homo sapiens_hsa003802.48903049
17ABC transporters_Homo sapiens_hsa020102.47650323
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45437548
19Linoleic acid metabolism_Homo sapiens_hsa005912.44074082
20Retinol metabolism_Homo sapiens_hsa008302.40171568
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35481620
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.35115086
23Phototransduction_Homo sapiens_hsa047442.29827351
24Chemical carcinogenesis_Homo sapiens_hsa052042.22583443
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97663218
26Nitrogen metabolism_Homo sapiens_hsa009101.88677767
27Nicotine addiction_Homo sapiens_hsa050331.80163612
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73480681
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72399879
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72257652
31Collecting duct acid secretion_Homo sapiens_hsa049661.71026948
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66188018
33Complement and coagulation cascades_Homo sapiens_hsa046101.62987153
34Vibrio cholerae infection_Homo sapiens_hsa051101.55479705
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44966076
36Fatty acid degradation_Homo sapiens_hsa000711.43304076
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42728748
38Histidine metabolism_Homo sapiens_hsa003401.40643240
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38791827
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34908979
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26784945
42Homologous recombination_Homo sapiens_hsa034401.25286063
43Basal transcription factors_Homo sapiens_hsa030221.22482740
44Selenocompound metabolism_Homo sapiens_hsa004501.22454501
45beta-Alanine metabolism_Homo sapiens_hsa004101.21558775
46Olfactory transduction_Homo sapiens_hsa047401.20397398
47Circadian entrainment_Homo sapiens_hsa047131.19944702
48Glycerolipid metabolism_Homo sapiens_hsa005611.18530411
49Ether lipid metabolism_Homo sapiens_hsa005651.17987257
50GnRH signaling pathway_Homo sapiens_hsa049121.17641546
51Long-term potentiation_Homo sapiens_hsa047201.16181710
52Amphetamine addiction_Homo sapiens_hsa050311.15200503
53Arachidonic acid metabolism_Homo sapiens_hsa005901.12421459
54Dilated cardiomyopathy_Homo sapiens_hsa054141.11226439
55Non-homologous end-joining_Homo sapiens_hsa034501.07309049
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07188114
57Axon guidance_Homo sapiens_hsa043601.04087871
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99682708
59GABAergic synapse_Homo sapiens_hsa047270.99315875
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98368906
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.98313174
62Choline metabolism in cancer_Homo sapiens_hsa052310.97747213
63Fanconi anemia pathway_Homo sapiens_hsa034600.97591027
64Peroxisome_Homo sapiens_hsa041460.93703758
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93398341
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.93111440
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90259216
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88823589
69Oxytocin signaling pathway_Homo sapiens_hsa049210.87470816
70Glutamatergic synapse_Homo sapiens_hsa047240.85347052
71Sphingolipid metabolism_Homo sapiens_hsa006000.85329801
72Dopaminergic synapse_Homo sapiens_hsa047280.84551699
73Lysine degradation_Homo sapiens_hsa003100.83938396
74Prion diseases_Homo sapiens_hsa050200.83213646
75Gap junction_Homo sapiens_hsa045400.82758410
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.81547349
77Starch and sucrose metabolism_Homo sapiens_hsa005000.81424327
78One carbon pool by folate_Homo sapiens_hsa006700.81384846
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81309810
80Allograft rejection_Homo sapiens_hsa053300.80704483
81Butanoate metabolism_Homo sapiens_hsa006500.80531255
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80197592
83Cocaine addiction_Homo sapiens_hsa050300.80131638
84Insulin secretion_Homo sapiens_hsa049110.80080285
85Ovarian steroidogenesis_Homo sapiens_hsa049130.79913545
86Phagosome_Homo sapiens_hsa041450.79050671
87Circadian rhythm_Homo sapiens_hsa047100.78548722
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74498909
89Regulation of autophagy_Homo sapiens_hsa041400.74431288
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73474973
91Gastric acid secretion_Homo sapiens_hsa049710.73284838
92Fatty acid biosynthesis_Homo sapiens_hsa000610.72635135
93Taste transduction_Homo sapiens_hsa047420.71963862
94Serotonergic synapse_Homo sapiens_hsa047260.71368467
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71304960
96Rheumatoid arthritis_Homo sapiens_hsa053230.69805474
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.67389652
98Morphine addiction_Homo sapiens_hsa050320.66273682
99Fatty acid elongation_Homo sapiens_hsa000620.65900767
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65565230
101Pyruvate metabolism_Homo sapiens_hsa006200.64616972
102Fatty acid metabolism_Homo sapiens_hsa012120.63926951
103Oocyte meiosis_Homo sapiens_hsa041140.63172521
104Salivary secretion_Homo sapiens_hsa049700.62913401
105PPAR signaling pathway_Homo sapiens_hsa033200.62159693
106Calcium signaling pathway_Homo sapiens_hsa040200.62091709
107Ras signaling pathway_Homo sapiens_hsa040140.61789070
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61448864
109Fat digestion and absorption_Homo sapiens_hsa049750.60624114
110Glioma_Homo sapiens_hsa052140.56583854
111Pertussis_Homo sapiens_hsa051330.55267640
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54420127
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53778184
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53740222
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.53653916
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.53471751
117Melanoma_Homo sapiens_hsa052180.52845809
118Melanogenesis_Homo sapiens_hsa049160.50236255
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49223168
120cAMP signaling pathway_Homo sapiens_hsa040240.47213366
121Type I diabetes mellitus_Homo sapiens_hsa049400.46110700
122Long-term depression_Homo sapiens_hsa047300.45836122
123Tyrosine metabolism_Homo sapiens_hsa003500.44065023
124ErbB signaling pathway_Homo sapiens_hsa040120.43867903
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42064736
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.40930513
127Metabolic pathways_Homo sapiens_hsa011000.39274379
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38771055
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37965677
130MAPK signaling pathway_Homo sapiens_hsa040100.37230501
131Phenylalanine metabolism_Homo sapiens_hsa003600.36673147
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35864661
133Renin secretion_Homo sapiens_hsa049240.35126682
134Vitamin digestion and absorption_Homo sapiens_hsa049770.34741663
135TGF-beta signaling pathway_Homo sapiens_hsa043500.34629395
136Rap1 signaling pathway_Homo sapiens_hsa040150.33931687
137VEGF signaling pathway_Homo sapiens_hsa043700.33777669
138Arginine biosynthesis_Homo sapiens_hsa002200.33705425
139Amoebiasis_Homo sapiens_hsa051460.33595174
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33476128
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33019968
142Carbon metabolism_Homo sapiens_hsa012000.31984933
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31961339
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.31451671
145Chemokine signaling pathway_Homo sapiens_hsa040620.30761883
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.30042854
147Renal cell carcinoma_Homo sapiens_hsa052110.29667937
148Staphylococcus aureus infection_Homo sapiens_hsa051500.29329905
149Dorso-ventral axis formation_Homo sapiens_hsa043200.28736305
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28596973
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28274272
152Arginine and proline metabolism_Homo sapiens_hsa003300.28209238
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27248886
154African trypanosomiasis_Homo sapiens_hsa051430.26957633
155Glucagon signaling pathway_Homo sapiens_hsa049220.26395903
156Viral myocarditis_Homo sapiens_hsa054160.26376348
157Leishmaniasis_Homo sapiens_hsa051400.26145519
158Tuberculosis_Homo sapiens_hsa051520.25745176
159Estrogen signaling pathway_Homo sapiens_hsa049150.24924032
160RNA polymerase_Homo sapiens_hsa030200.24718753
161Propanoate metabolism_Homo sapiens_hsa006400.23959266
162Prolactin signaling pathway_Homo sapiens_hsa049170.22486613
163Asthma_Homo sapiens_hsa053100.22072649
164Bile secretion_Homo sapiens_hsa049760.22000116
165Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21560912
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19856359
167Sulfur metabolism_Homo sapiens_hsa009200.19297659
168Platelet activation_Homo sapiens_hsa046110.18180606
169Type II diabetes mellitus_Homo sapiens_hsa049300.16688055

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