UTY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.87026959
2central nervous system myelination (GO:0022010)4.87026959
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.62223349
4presynaptic membrane assembly (GO:0097105)4.42991548
5positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.27250887
6presynaptic membrane organization (GO:0097090)4.12919931
7startle response (GO:0001964)4.12236381
8mesenchymal cell differentiation involved in renal system development (GO:2001012)4.05303894
9mesenchymal cell differentiation involved in kidney development (GO:0072161)4.05303894
10limb bud formation (GO:0060174)3.97954161
11cilium or flagellum-dependent cell motility (GO:0001539)3.87929649
12long-chain fatty acid biosynthetic process (GO:0042759)3.77472142
13neural tube formation (GO:0001841)3.76811147
14positive regulation of gamma-delta T cell activation (GO:0046645)3.76604448
15import into cell (GO:0098657)3.67016904
16L-amino acid import (GO:0043092)3.63614795
17epithelial cilium movement (GO:0003351)3.62597717
18protein K11-linked deubiquitination (GO:0035871)3.54328026
19pyrimidine nucleobase catabolic process (GO:0006208)3.52357354
20regulation of timing of cell differentiation (GO:0048505)3.51573484
21regulation of inositol phosphate biosynthetic process (GO:0010919)3.46757443
22establishment of protein localization to Golgi (GO:0072600)3.43968061
23positive regulation of granulocyte differentiation (GO:0030854)3.42884884
24righting reflex (GO:0060013)3.39972039
25regulation of B cell receptor signaling pathway (GO:0050855)3.37120206
26cerebral cortex radially oriented cell migration (GO:0021799)3.35177591
27microglial cell activation (GO:0001774)3.34820181
28negative regulation of neurotransmitter transport (GO:0051589)3.33935964
29retina layer formation (GO:0010842)3.33609012
30neuron remodeling (GO:0016322)3.31700847
31fatty acid elongation (GO:0030497)3.29777733
32keratinocyte development (GO:0003334)3.27134780
33neuron cell-cell adhesion (GO:0007158)3.25977664
34nucleotide transmembrane transport (GO:1901679)3.25859667
35negative T cell selection (GO:0043383)3.24890305
36activated T cell proliferation (GO:0050798)3.21266309
37reflex (GO:0060004)3.18129632
38cilium movement (GO:0003341)3.17758515
39mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.14104666
40positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.14104666
41response to redox state (GO:0051775)3.12132852
42negative thymic T cell selection (GO:0045060)3.12031338
43cell wall macromolecule catabolic process (GO:0016998)3.11449370
44cranial nerve development (GO:0021545)3.11309912
45mesenchymal cell differentiation (GO:0048762)3.08353324
46G-protein coupled receptor internalization (GO:0002031)3.05232012
47negative regulation of neurotransmitter secretion (GO:0046929)3.05178576
48transmission of nerve impulse (GO:0019226)3.01591141
49regulation of gamma-delta T cell activation (GO:0046643)3.00474463
50platelet dense granule organization (GO:0060155)2.98648511
51negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95322544
52nucleobase catabolic process (GO:0046113)2.94703802
53eye photoreceptor cell differentiation (GO:0001754)2.93664085
54photoreceptor cell differentiation (GO:0046530)2.93664085
55negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91988480
56negative regulation of translation, ncRNA-mediated (GO:0040033)2.91988480
57regulation of translation, ncRNA-mediated (GO:0045974)2.91988480
58regulation of gamma-delta T cell differentiation (GO:0045586)2.91927964
59protein targeting to Golgi (GO:0000042)2.91688722
60polyol transport (GO:0015791)2.91277880
61axoneme assembly (GO:0035082)2.88678033
62positive T cell selection (GO:0043368)2.88583475
63phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88198132
64interferon-gamma production (GO:0032609)2.83631657
65nonmotile primary cilium assembly (GO:0035058)2.82872861
66postsynaptic membrane organization (GO:0001941)2.82234018
67cell morphogenesis involved in neuron differentiation (GO:0048667)2.81778963
68cell differentiation involved in kidney development (GO:0061005)2.79853982
69cell differentiation involved in metanephros development (GO:0072202)2.78299548
70response to epinephrine (GO:0071871)2.78213827
71regulation of development, heterochronic (GO:0040034)2.76885810
72organ growth (GO:0035265)2.74665227
73positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.74364923
74histone mRNA catabolic process (GO:0071044)2.73980001
75glycerophospholipid catabolic process (GO:0046475)2.72840654
76myelination (GO:0042552)2.71808700
77photoreceptor cell maintenance (GO:0045494)2.71601999
78regulation of pigment cell differentiation (GO:0050932)2.70510866
79regulation of cilium movement (GO:0003352)2.70027527
80cilium morphogenesis (GO:0060271)2.69814122
81protein localization to cilium (GO:0061512)2.69092670
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69014598
83auditory behavior (GO:0031223)2.68995097
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.66971194
85mechanosensory behavior (GO:0007638)2.66970303
86inner ear receptor stereocilium organization (GO:0060122)2.66879475
87short-term memory (GO:0007614)2.64861016
88amino acid import (GO:0043090)2.63676742
89fucose catabolic process (GO:0019317)2.62590419
90L-fucose metabolic process (GO:0042354)2.62590419
91L-fucose catabolic process (GO:0042355)2.62590419
92neutrophil mediated immunity (GO:0002446)2.61444124
93seminiferous tubule development (GO:0072520)2.60776698
94ensheathment of neurons (GO:0007272)2.60536304
95axon ensheathment (GO:0008366)2.60536304
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.59920253
97positive regulation of protein kinase C signaling (GO:0090037)2.58352892
98cell wall macromolecule metabolic process (GO:0044036)2.58238092
99glutamate receptor signaling pathway (GO:0007215)2.57469702
100prostate gland growth (GO:0060736)2.57374094
101positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.57050112
102auditory receptor cell stereocilium organization (GO:0060088)2.56648991
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56354099
104oligodendrocyte differentiation (GO:0048709)2.56297051
105developmental pigmentation (GO:0048066)2.56171508
106GPI anchor metabolic process (GO:0006505)2.56126264
107brain morphogenesis (GO:0048854)2.56015188
108response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.55073828
109cornea development in camera-type eye (GO:0061303)2.54437287
110myeloid leukocyte mediated immunity (GO:0002444)2.53103440
111negative regulation of interleukin-1 beta production (GO:0032691)2.51551832
112macrophage activation (GO:0042116)2.51193564
113cellular response to epinephrine stimulus (GO:0071872)2.50978010
114detection of molecule of bacterial origin (GO:0032490)2.50227061
115regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.49380376
116gamma-aminobutyric acid signaling pathway (GO:0007214)2.46344563
117positive regulation of meiosis (GO:0045836)2.46025490
118GPI anchor biosynthetic process (GO:0006506)2.45595519
119lateral sprouting from an epithelium (GO:0060601)2.45414831
120otic vesicle formation (GO:0030916)2.44284208
121regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.44279649
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43408323
123regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.42718170
124regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41894717
125protein K63-linked deubiquitination (GO:0070536)2.41724640
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.41174600
127regulation of platelet aggregation (GO:0090330)2.40563335
128secretory granule organization (GO:0033363)2.40320637
129RNA destabilization (GO:0050779)2.39849546
130negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38936087
131cranial nerve morphogenesis (GO:0021602)2.38333148
132negative regulation of myoblast differentiation (GO:0045662)2.38152680
133histone H3-K9 methylation (GO:0051567)2.38016857
134B cell receptor signaling pathway (GO:0050853)2.36579105
135regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.35603656
136behavioral response to nicotine (GO:0035095)2.35371110
137indolalkylamine metabolic process (GO:0006586)2.35155714
138positive regulation of interleukin-1 beta secretion (GO:0050718)2.34961247
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34839035
140spinal cord motor neuron differentiation (GO:0021522)2.34754923
141regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34586901
142regulation of protein glycosylation (GO:0060049)2.33922770
143negative regulation of execution phase of apoptosis (GO:1900118)2.33702563
144cranial nerve structural organization (GO:0021604)2.33515260
145male sex determination (GO:0030238)2.33249421
146regulation of collateral sprouting (GO:0048670)2.33208269
147regulation of interleukin-1 beta secretion (GO:0050706)2.33155205
148intraciliary transport (GO:0042073)2.32854284
149cyclic nucleotide catabolic process (GO:0009214)2.32548960
150negative regulation of cell killing (GO:0031342)2.32543311
151negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32543311
152histone H3-K4 trimethylation (GO:0080182)2.32189501
153neuron recognition (GO:0008038)2.31901980
154vocalization behavior (GO:0071625)2.30880829
155positive regulation of action potential (GO:0045760)2.30821110
156positive regulation of synapse assembly (GO:0051965)2.30620897
157mast cell activation (GO:0045576)2.30596369
158negative regulation of protein localization to cell surface (GO:2000009)2.30381838
159protein palmitoylation (GO:0018345)2.30145491
160positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.29827339
161regulation of interleukin-6 biosynthetic process (GO:0045408)2.29629856
162serotonin receptor signaling pathway (GO:0007210)2.29562615
163regulation of somitogenesis (GO:0014807)2.27439864
164response to monoamine (GO:0071867)2.26792855
165response to catecholamine (GO:0071869)2.26792855
166positive regulation of meiotic cell cycle (GO:0051446)2.26575943
167negative regulation of Rho protein signal transduction (GO:0035024)2.26519317
168rRNA catabolic process (GO:0016075)2.25956451
169glycine transport (GO:0015816)2.25942202
170DNA double-strand break processing (GO:0000729)2.25912750
171calcium ion import (GO:0070509)2.25887213
172protein localization to Golgi apparatus (GO:0034067)2.25847459
173olfactory bulb development (GO:0021772)2.25757123
174neurotransmitter uptake (GO:0001504)2.25427632
175DNA deamination (GO:0045006)2.25396461
176cilium organization (GO:0044782)2.25064795
177regulation of germinal center formation (GO:0002634)2.25052989
178RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.24269822
179positive regulation of alpha-beta T cell proliferation (GO:0046641)2.23627998
180detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23400745
181phospholipid homeostasis (GO:0055091)2.23193599
182regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.22657988
183cellular response to ethanol (GO:0071361)2.21928911
184regulation of alpha-beta T cell proliferation (GO:0046640)2.21388826
185positive regulation of interleukin-1 secretion (GO:0050716)2.20940907
186regulation of B cell differentiation (GO:0045577)2.20512977
187T cell selection (GO:0045058)2.19861082
188protein K48-linked deubiquitination (GO:0071108)2.19738901
189negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.18899476
190regulation of glucokinase activity (GO:0033131)2.18624570
191regulation of hexokinase activity (GO:1903299)2.18624570
192histone H3-K9 modification (GO:0061647)2.18510282
193regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.17406766
194positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.17406766
195indolalkylamine catabolic process (GO:0046218)2.16582621
196tryptophan catabolic process (GO:0006569)2.16582621
197indole-containing compound catabolic process (GO:0042436)2.16582621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.95941392
2EZH2_22144423_ChIP-Seq_EOC_Human2.90998595
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75591373
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67493164
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60871594
6TAF15_26573619_Chip-Seq_HEK293_Human2.58860457
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55640395
8ZNF274_21170338_ChIP-Seq_K562_Hela2.45528809
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.40636392
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40381555
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.35453297
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25200327
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23452317
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21071305
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20487510
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14475730
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.14320752
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.14179890
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07447291
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05753449
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03831739
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.03293281
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.97193698
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96878181
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94787813
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92651627
27AR_21572438_ChIP-Seq_LNCaP_Human1.91738456
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91549558
29P300_19829295_ChIP-Seq_ESCs_Human1.90274490
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90112431
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.87531876
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83165326
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81493007
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81192666
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.79383149
36VDR_22108803_ChIP-Seq_LS180_Human1.77408391
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77329887
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.76755355
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76577505
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72963006
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72756565
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72756565
43RUNX_20019798_ChIP-Seq_JUKART_Human1.70619727
44IGF1R_20145208_ChIP-Seq_DFB_Human1.69940193
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68785175
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68065418
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67619150
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66429426
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.65590980
50FUS_26573619_Chip-Seq_HEK293_Human1.65264081
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64926325
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.63619410
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.63562155
54SUZ12_18555785_Chip-Seq_ESCs_Mouse1.62019338
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61839684
56P53_22387025_ChIP-Seq_ESCs_Mouse1.60451131
57SMAD4_21799915_ChIP-Seq_A2780_Human1.60065319
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.59295794
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55542645
60STAT3_18555785_Chip-Seq_ESCs_Mouse1.53269481
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.52991192
62P300_18555785_Chip-Seq_ESCs_Mouse1.51754985
63RNF2_27304074_Chip-Seq_NSC_Mouse1.51522438
64IRF1_19129219_ChIP-ChIP_H3396_Human1.50546450
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49983531
66BCAT_22108803_ChIP-Seq_LS180_Human1.48091963
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.47742194
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46281080
69ER_23166858_ChIP-Seq_MCF-7_Human1.45826695
70CBP_20019798_ChIP-Seq_JUKART_Human1.44812990
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44812990
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.43102743
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42756086
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42532197
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42189582
76RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42076176
77STAT3_23295773_ChIP-Seq_U87_Human1.42053774
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41215463
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41114005
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.40756335
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.39503117
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39403420
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36051108
84OCT4_18555785_Chip-Seq_ESCs_Mouse1.35829939
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35096752
86GATA1_22025678_ChIP-Seq_K562_Human1.34738243
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34591854
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32288951
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.30767191
90PU1_27457419_Chip-Seq_LIVER_Mouse1.30719236
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30354772
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.30055654
93TCF4_23295773_ChIP-Seq_U87_Human1.29292331
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.28939606
95KLF4_18555785_Chip-Seq_ESCs_Mouse1.28929964
96EWS_26573619_Chip-Seq_HEK293_Human1.28778011
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27014956
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27014956
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26941653
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26602911
101TP53_18474530_ChIP-ChIP_U2OS_Human1.25908447
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25803541
103ZFX_18555785_Chip-Seq_ESCs_Mouse1.25741972
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25381960
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23906697
106DROSHA_22980978_ChIP-Seq_HELA_Human1.22801507
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21720943
108CTCF_18555785_Chip-Seq_ESCs_Mouse1.21331509
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21036416
110RUNX2_22187159_ChIP-Seq_PCA_Human1.20771097
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.19790763
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.19550461
113TP53_16413492_ChIP-PET_HCT116_Human1.19089752
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.18456311
115ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18153590
116NANOG_19829295_ChIP-Seq_ESCs_Human1.16927698
117SOX2_19829295_ChIP-Seq_ESCs_Human1.16927698
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.16674615
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16259344
120AR_25329375_ChIP-Seq_VCAP_Human1.15425538
121AHR_22903824_ChIP-Seq_MCF-7_Human1.15196828
122TCF4_22108803_ChIP-Seq_LS180_Human1.13290182
123GATA3_26560356_Chip-Seq_TH2_Human1.12228609
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11722702
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08699972
126FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07962133
127VDR_24787735_ChIP-Seq_THP-1_Human1.07228731
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06154826
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03713668
130CDX2_22108803_ChIP-Seq_LS180_Human1.03567225
131TP53_22573176_ChIP-Seq_HFKS_Human1.02739133
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02599340
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02159450
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01726515
135IRF8_27001747_Chip-Seq_BMDM_Mouse0.99950237
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98774391
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98706775
138KDM2B_26808549_Chip-Seq_REH_Human0.98629416
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.98249775
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97402072
141SCL_19346495_ChIP-Seq_HPC-7_Human0.96781145
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.95995470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.52858520
2MP0001188_hyperpigmentation3.50565447
3MP0000566_synostosis3.36227295
4MP0003136_yellow_coat_color3.32256595
5MP0002102_abnormal_ear_morphology3.14557647
6MP0005171_absent_coat_pigmentation3.12793684
7MP0006292_abnormal_olfactory_placode2.89917092
8MP0004742_abnormal_vestibular_system2.89326384
9MP0005409_darkened_coat_color2.63561910
10MP0001486_abnormal_startle_reflex2.54982535
11MP0004381_abnormal_hair_follicle2.50657675
12MP0003880_abnormal_central_pattern2.43744780
13MP0003787_abnormal_imprinting2.26845911
14MP0008260_abnormal_autophagy2.14325464
15MP0000920_abnormal_myelination2.06125797
16MP0001835_abnormal_antigen_presentation1.97283639
17MP0002928_abnormal_bile_duct1.91795025
18MP0002653_abnormal_ependyma_morphology1.86010720
19MP0005646_abnormal_pituitary_gland1.85123037
20MP0003646_muscle_fatigue1.84867560
21MP0001661_extended_life_span1.83613820
22MP0001800_abnormal_humoral_immune1.82853620
23MP0004134_abnormal_chest_morphology1.78379730
24MP0000383_abnormal_hair_follicle1.75200218
25MP0001986_abnormal_taste_sensitivity1.70372172
26MP0009745_abnormal_behavioral_response1.69936292
27MP0005671_abnormal_response_to1.68694342
28MP0002272_abnormal_nervous_system1.67404891
29MP0000026_abnormal_inner_ear1.64804458
30MP0004142_abnormal_muscle_tone1.64163882
31MP0001905_abnormal_dopamine_level1.63764645
32MP0002277_abnormal_respiratory_mucosa1.61427254
33MP0005379_endocrine/exocrine_gland_phen1.60162301
34MP0001968_abnormal_touch/_nociception1.59256885
35MP0009046_muscle_twitch1.57724772
36MP0002572_abnormal_emotion/affect_behav1.57660171
37MP0001963_abnormal_hearing_physiology1.53019555
38MP0002876_abnormal_thyroid_physiology1.52367003
39MP0000465_gastrointestinal_hemorrhage1.51603598
40MP0003950_abnormal_plasma_membrane1.50882144
41MP0005645_abnormal_hypothalamus_physiol1.50628033
42MP0005084_abnormal_gallbladder_morpholo1.49712508
43MP0005167_abnormal_blood-brain_barrier1.49574184
44MP0005551_abnormal_eye_electrophysiolog1.49205651
45MP0000778_abnormal_nervous_system1.48843990
46MP0010386_abnormal_urinary_bladder1.47408101
47MP0002736_abnormal_nociception_after1.44782263
48MP0005075_abnormal_melanosome_morpholog1.44699816
49MP0003690_abnormal_glial_cell1.44333897
50MP0004147_increased_porphyrin_level1.42359382
51MP0000462_abnormal_digestive_system1.41613913
52MP0002067_abnormal_sensory_capabilities1.41493165
53MP0003635_abnormal_synaptic_transmissio1.38701523
54MP0000015_abnormal_ear_pigmentation1.38511464
55MP0000631_abnormal_neuroendocrine_gland1.37288387
56MP0002452_abnormal_antigen_presenting1.37057342
57MP0002723_abnormal_immune_serum1.36902391
58MP0002064_seizures1.36707430
59MP0003938_abnormal_ear_development1.36313667
60MP0002735_abnormal_chemical_nociception1.34761581
61MP0005000_abnormal_immune_tolerance1.31723833
62MP0002938_white_spotting1.31379972
63MP0004885_abnormal_endolymph1.30469021
64MP0001485_abnormal_pinna_reflex1.30366914
65MP0001440_abnormal_grooming_behavior1.29173650
66MP0002734_abnormal_mechanical_nocicepti1.27777530
67MP0001529_abnormal_vocalization1.27749464
68MP0002420_abnormal_adaptive_immunity1.26918779
69MP0002166_altered_tumor_susceptibility1.26852813
70MP0003122_maternal_imprinting1.26586662
71MP0001819_abnormal_immune_cell1.25315918
72MP0009764_decreased_sensitivity_to1.25181829
73MP0002557_abnormal_social/conspecific_i1.25090029
74MP0002063_abnormal_learning/memory/cond1.24347760
75MP0005670_abnormal_white_adipose1.23739567
76MP0003763_abnormal_thymus_physiology1.23362734
77MP0004859_abnormal_synaptic_plasticity1.21506673
78MP0002249_abnormal_larynx_morphology1.21030412
79MP0000685_abnormal_immune_system1.20892541
80MP0010678_abnormal_skin_adnexa1.20764843
81MP0004484_altered_response_of1.20209984
82MP0004145_abnormal_muscle_electrophysio1.19834157
83MP0005423_abnormal_somatic_nervous1.18669393
84MP0002419_abnormal_innate_immunity1.16165927
85MP0001346_abnormal_lacrimal_gland1.15223231
86MP0004270_analgesia1.14316241
87MP0005387_immune_system_phenotype1.12276936
88MP0001790_abnormal_immune_system1.12276936
89MP0001970_abnormal_pain_threshold1.12136317
90MP0009785_altered_susceptibility_to1.10937945
91MP0005174_abnormal_tail_pigmentation1.10680317
92MP0003937_abnormal_limbs/digits/tail_de1.10289635
93MP0001501_abnormal_sleep_pattern1.10133202
94MP0006276_abnormal_autonomic_nervous1.08825364
95MP0005253_abnormal_eye_physiology1.08584391
96MP0003828_pulmonary_edema1.08081693
97MP0001984_abnormal_olfaction1.07658941
98MP0001502_abnormal_circadian_rhythm1.07482534
99MP0006072_abnormal_retinal_apoptosis1.06674768
100MP0002163_abnormal_gland_morphology1.05254427
101MP0006054_spinal_hemorrhage1.05081770
102MP0003724_increased_susceptibility_to1.04554517
103MP0000689_abnormal_spleen_morphology1.04268440
104MP0004883_abnormal_blood_vessel1.03586493
105MP0004043_abnormal_pH_regulation1.02813370
106MP0002752_abnormal_somatic_nervous1.00754708
107MP0009250_abnormal_appendicular_skeleto1.00203227
108MP0002138_abnormal_hepatobiliary_system0.99810051
109MP0004130_abnormal_muscle_cell0.99160195
110MP0002184_abnormal_innervation0.98517548
111MP0000427_abnormal_hair_cycle0.97168541
112MP0003656_abnormal_erythrocyte_physiolo0.95550694
113MP0006082_CNS_inflammation0.94628364
114MP0002822_catalepsy0.94513577
115MP0001545_abnormal_hematopoietic_system0.93802767
116MP0005397_hematopoietic_system_phenotyp0.93802767
117MP0009780_abnormal_chondrocyte_physiolo0.93071309
118MP0000716_abnormal_immune_system0.92956280
119MP0002405_respiratory_system_inflammati0.92670708
120MP0002229_neurodegeneration0.92311813
121MP0003183_abnormal_peptide_metabolism0.92240484
122MP0005025_abnormal_response_to0.92131587
123MP0005464_abnormal_platelet_physiology0.91185961
124MP0000613_abnormal_salivary_gland0.90212337
125MP0005248_abnormal_Harderian_gland0.89958265
126MP0005310_abnormal_salivary_gland0.89933310
127MP0004215_abnormal_myocardial_fiber0.89494148
128MP0008872_abnormal_physiological_respon0.89428168
129MP0002398_abnormal_bone_marrow0.87581469
130MP0002837_dystrophic_cardiac_calcinosis0.87264746
131MP0001764_abnormal_homeostasis0.87117397
132MP0003633_abnormal_nervous_system0.86912237
133MP0002009_preneoplasia0.86307581
134MP0003252_abnormal_bile_duct0.86215647
135MP0002882_abnormal_neuron_morphology0.85640110
136MP0002095_abnormal_skin_pigmentation0.85522720
137MP0003045_fibrosis0.85215702
138MP0001299_abnormal_eye_distance/0.85053565
139MP0001177_atelectasis0.84522794
140MP0003436_decreased_susceptibility_to0.84470713
141MP0002177_abnormal_outer_ear0.84442993
142MP0002733_abnormal_thermal_nociception0.81738658
143MP0000372_irregular_coat_pigmentation0.78264219
144MP0002006_tumorigenesis0.77753811
145MP0002722_abnormal_immune_system0.77244837
146MP0003121_genomic_imprinting0.76413397
147MP0000569_abnormal_digit_pigmentation0.76225405
148MP0004924_abnormal_behavior0.75741362
149MP0005386_behavior/neurological_phenoty0.75741362
150MP0005408_hypopigmentation0.74443656
151MP0002638_abnormal_pupillary_reflex0.74335473
152MP0003195_calcinosis0.74254106
153MP0000762_abnormal_tongue_morphology0.72987345
154MP0001664_abnormal_digestion0.72851015
155MP0000579_abnormal_nail_morphology0.72794244
156MP0002066_abnormal_motor_capabilities/c0.72511960
157MP0002233_abnormal_nose_morphology0.70949317
158MP0005195_abnormal_posterior_eye0.70499433
159MP0008995_early_reproductive_senescence0.70148281
160MP0009697_abnormal_copulation0.69463272

Predicted human phenotypes

RankGene SetZ-score
1White forelock (HP:0002211)3.76864931
2Pancreatic cysts (HP:0001737)3.74935666
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74815973
4Septo-optic dysplasia (HP:0100842)3.73132362
5Pancreatic fibrosis (HP:0100732)3.54969913
6Patchy hypopigmentation of hair (HP:0011365)3.53068276
7Bile duct proliferation (HP:0001408)3.39279880
8Abnormal biliary tract physiology (HP:0012439)3.39279880
9Chromsome breakage (HP:0040012)3.32536751
10True hermaphroditism (HP:0010459)3.27654783
11Focal motor seizures (HP:0011153)3.26147557
12Aplasia cutis congenita (HP:0001057)3.18925594
13Duplicated collecting system (HP:0000081)3.17182405
14Febrile seizures (HP:0002373)3.10103349
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.07457575
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07457575
17Osteomalacia (HP:0002749)3.07085781
18Abnormality of midbrain morphology (HP:0002418)2.97580925
19Molar tooth sign on MRI (HP:0002419)2.97580925
20Tubulointerstitial nephritis (HP:0001970)2.94883006
21Abnormality of incisor morphology (HP:0011063)2.92255255
22Parakeratosis (HP:0001036)2.82984674
23Abnormality of the renal collecting system (HP:0004742)2.81312750
24Prostate neoplasm (HP:0100787)2.77947889
25Decreased circulating renin level (HP:0003351)2.71074409
26Congenital primary aphakia (HP:0007707)2.68701389
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.67112858
28Absent/shortened dynein arms (HP:0200106)2.67112858
29Gait imbalance (HP:0002141)2.65288923
30Duplication of thumb phalanx (HP:0009942)2.65129416
31Upper limb muscle weakness (HP:0003484)2.64834341
32Nephrogenic diabetes insipidus (HP:0009806)2.64699760
33Stomatitis (HP:0010280)2.63573420
34Congenital sensorineural hearing impairment (HP:0008527)2.62547380
35Nasolacrimal duct obstruction (HP:0000579)2.59238204
36Submucous cleft hard palate (HP:0000176)2.58388352
37Decreased central vision (HP:0007663)2.53286368
38Absent septum pellucidum (HP:0001331)2.52886160
39Thyroiditis (HP:0100646)2.52547945
40Cupped ear (HP:0000378)2.51351196
41Progressive cerebellar ataxia (HP:0002073)2.46886962
42Fair hair (HP:0002286)2.46427348
43Hyperventilation (HP:0002883)2.45605759
44Optic nerve hypoplasia (HP:0000609)2.45238531
45Gaze-evoked nystagmus (HP:0000640)2.44166739
46Abnormal drinking behavior (HP:0030082)2.42858842
47Polydipsia (HP:0001959)2.42858842
48Type II lissencephaly (HP:0007260)2.39323272
49Abolished electroretinogram (ERG) (HP:0000550)2.38605241
50Neoplasm of the tracheobronchial system (HP:0100552)2.38014092
51Renal cortical cysts (HP:0000803)2.34915772
52Abnormality of the septum pellucidum (HP:0007375)2.33754432
53Blue irides (HP:0000635)2.30910357
54Genital tract atresia (HP:0001827)2.29869814
55Hypophosphatemic rickets (HP:0004912)2.29642287
56Genetic anticipation (HP:0003743)2.29485669
57Alacrima (HP:0000522)2.27675386
58Abnormal respiratory epithelium morphology (HP:0012253)2.27667630
59Abnormal respiratory motile cilium morphology (HP:0005938)2.27667630
60Enlarged kidneys (HP:0000105)2.27456222
61T lymphocytopenia (HP:0005403)2.27129250
62Decreased lacrimation (HP:0000633)2.27115669
63Abnormality of the lacrimal duct (HP:0011481)2.25992521
64Optic neuritis (HP:0100653)2.25942165
65Retrobulbar optic neuritis (HP:0100654)2.25942165
66Cystic liver disease (HP:0006706)2.25345917
67Abnormality of the nasal septum (HP:0000419)2.24960044
68Gingival bleeding (HP:0000225)2.21480747
69Abnormal ciliary motility (HP:0012262)2.20805354
70Gastroesophageal reflux (HP:0002020)2.20442295
71Abnormality of T cell number (HP:0011839)2.17994227
72Overfolded helix (HP:0000396)2.17561263
73Epileptic encephalopathy (HP:0200134)2.17332632
74Abnormality of the nasolacrimal system (HP:0000614)2.16828948
75Vaginal atresia (HP:0000148)2.16692027
76Protruding tongue (HP:0010808)2.15165264
77Prolonged neonatal jaundice (HP:0006579)2.13835258
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13212652
79Absent speech (HP:0001344)2.12961645
80Xerostomia (HP:0000217)2.12766797
81Poor coordination (HP:0002370)2.12251575
82Alveolar cell carcinoma (HP:0006519)2.11962704
83Congenital hepatic fibrosis (HP:0002612)2.10555855
84Abnormality of secondary sexual hair (HP:0009888)2.10384603
85Abnormality of the axillary hair (HP:0100134)2.10384603
86Generalized hypopigmentation of hair (HP:0011358)2.10067219
87Anomalous pulmonary venous return (HP:0010772)2.09139357
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.08790297
89Hip dysplasia (HP:0001385)2.06921139
90Amyotrophic lateral sclerosis (HP:0007354)2.03233080
91Polyphagia (HP:0002591)2.02468345
92Attenuation of retinal blood vessels (HP:0007843)2.01896027
93Synostosis involving the elbow (HP:0003938)2.01719782
94Humeroradial synostosis (HP:0003041)2.01719782
95Myositis (HP:0100614)2.01508531
96Lissencephaly (HP:0001339)2.00578317
97Recurrent gram-negative bacterial infections (HP:0005420)1.99279369
98Aplasia involving bones of the extremities (HP:0009825)1.98692555
99Aplasia involving bones of the upper limbs (HP:0009823)1.98692555
100Aplasia of the phalanges of the hand (HP:0009802)1.98692555
101Orchitis (HP:0100796)1.95766181
102Prolonged partial thromboplastin time (HP:0003645)1.95533523
103Conical tooth (HP:0000698)1.94936608
104Medial flaring of the eyebrow (HP:0010747)1.94770023
105Hypoplasia of the iris (HP:0007676)1.94362367
106Tubulointerstitial abnormality (HP:0001969)1.94070891
107Abnormal hair whorl (HP:0010721)1.93900136
108Elevated erythrocyte sedimentation rate (HP:0003565)1.93292945
109Short tibia (HP:0005736)1.93062593
110Peripheral hypomyelination (HP:0007182)1.91826452
111Widely spaced teeth (HP:0000687)1.91378270
112Recurrent bronchitis (HP:0002837)1.91324755
113Recurrent bacterial skin infections (HP:0005406)1.91284015
114Abnormality of the renal medulla (HP:0100957)1.90789582
115Abnormality of the corticospinal tract (HP:0002492)1.90676834
116Intestinal atresia (HP:0011100)1.89917699
117Specific learning disability (HP:0001328)1.89292450
118Asplenia (HP:0001746)1.88378926
119Mixed hearing impairment (HP:0000410)1.86517676
120Polyuria (HP:0000103)1.86370355
121Hemiplegia (HP:0002301)1.86195695
122Abnormality of the pulmonary veins (HP:0011718)1.84817588
123Hematochezia (HP:0002573)1.84506355
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.84474923
125Broad-based gait (HP:0002136)1.84280623
126Chronic hepatic failure (HP:0100626)1.84075197
127Abnormality of salivation (HP:0100755)1.84041959
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83405291
129Fibular hypoplasia (HP:0003038)1.83235087
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82725182
131Stomach cancer (HP:0012126)1.82275442
132Abnormality of eosinophils (HP:0001879)1.81369308
133Hypokalemic alkalosis (HP:0001949)1.81184963
134Abnormality of the renal cortex (HP:0011035)1.80896414
135Metabolic alkalosis (HP:0200114)1.80122545
136Keratoconjunctivitis (HP:0001096)1.79390444
137Postaxial foot polydactyly (HP:0001830)1.78742400
138Abnormal rod and cone electroretinograms (HP:0008323)1.78265076
139Renal agenesis (HP:0000104)1.78211827
140Abnormally folded helix (HP:0008544)1.77784908
141Hypomagnesemia (HP:0002917)1.77464914
142Absent radius (HP:0003974)1.77278372
143Abnormality of the parietal bone (HP:0002696)1.77012882
144Leukocytosis (HP:0001974)1.76578320
145Atelectasis (HP:0100750)1.74631934
146Tubular atrophy (HP:0000092)1.73979531
147Chronic sinusitis (HP:0011109)1.73748694
148Aplasia/Hypoplasia of the fovea (HP:0008060)1.73625124
149Hypoplasia of the fovea (HP:0007750)1.73625124
150Aplasia involving forearm bones (HP:0009822)1.73614427
151Absent forearm bone (HP:0003953)1.73614427
152Congenital stationary night blindness (HP:0007642)1.73096140
153Abnormal respiratory motile cilium physiology (HP:0012261)1.72717319
154Recurrent fungal infections (HP:0002841)1.71666545
155Hyperkalemia (HP:0002153)1.71542999
156Abnormal delayed hypersensitivity skin test (HP:0002963)1.71323719
157Male pseudohermaphroditism (HP:0000037)1.70904096
158Encephalitis (HP:0002383)1.70592134
159Excessive salivation (HP:0003781)1.69679540
160Drooling (HP:0002307)1.69679540
161Conjugated hyperbilirubinemia (HP:0002908)1.69235322
162Pachygyria (HP:0001302)1.69082231
163Atonic seizures (HP:0010819)1.69028158
164Growth hormone deficiency (HP:0000824)1.68905894
165Clumsiness (HP:0002312)1.68845321
166Spontaneous abortion (HP:0005268)1.67480992
167Papillary thyroid carcinoma (HP:0002895)1.67115059
168Constricted visual fields (HP:0001133)1.67082901
169Dialeptic seizures (HP:0011146)1.66651185
170Methylmalonic acidemia (HP:0002912)1.66351775
171Supernumerary spleens (HP:0009799)1.65046068
172Abnormality of molar (HP:0011077)1.64748959
173Abnormality of molar morphology (HP:0011070)1.64748959
174Recurrent sinusitis (HP:0011108)1.64237219
175Pulmonary artery stenosis (HP:0004415)1.64134924
176Panhypogammaglobulinemia (HP:0003139)1.64095037
177Nephronophthisis (HP:0000090)1.63741828
178Hemiparesis (HP:0001269)1.63653765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.61415956
2INSRR3.47743682
3BLK2.88189043
4MKNK22.71426772
5TNIK2.70748759
6STK392.45516678
7PINK12.21936220
8PKN12.15336298
9MAP4K21.93512767
10ZAK1.90544475
11MKNK11.88171252
12GRK11.85411545
13OXSR11.84937960
14ACVR1B1.79860570
15NTRK31.71231806
16MAP2K71.63420446
17NEK61.59449166
18MAP4K11.58194692
19EIF2AK21.53661636
20CDK191.53003771
21AKT31.46309791
22SYK1.44187007
23MAP3K141.43507800
24ITK1.41282834
25BMPR1B1.40965360
26BRSK21.40393932
27STK161.38398401
28TXK1.35250516
29BTK1.34749077
30GRK71.30800738
31BCR1.30409248
32TAOK31.30394644
33PRPF4B1.29659040
34EPHB11.27997291
35MAPK131.25970899
36FRK1.21593870
37YES11.21495933
38MAP3K131.19484946
39WNK41.19256552
40ADRBK21.17794318
41EPHA41.16840596
42BMPR21.16830315
43CAMKK21.15176838
44WNK11.08148360
45EPHA31.07789631
46ERBB31.07382642
47PBK1.05289807
48CLK11.04798641
49IKBKE1.04484282
50PIK3CA1.04112857
51CDK31.03979178
52KIT1.03834388
53BRD41.03127765
54RIPK41.01337311
55MAPK151.00117723
56FES0.97838955
57PRKCE0.97155336
58IRAK40.96691331
59CAMK1G0.96153191
60PLK20.96136395
61FGR0.94458202
62IKBKB0.89841113
63FGFR20.89530635
64NUAK10.88849454
65GRK60.88649227
66PIK3CG0.87939943
67CAMK2B0.87580948
68LYN0.87555000
69HCK0.86059256
70MUSK0.85772084
71TGFBR20.85211319
72CSF1R0.85032611
73CSNK1A1L0.84219120
74MST40.84182262
75CAMK40.83990976
76CAMK2A0.83985944
77PTK2B0.83798282
78TNK20.83427245
79LCK0.83217213
80SGK4940.83212133
81SGK2230.83212133
82JAK30.81886321
83TRIM280.80895054
84IRAK10.80740179
85SRPK10.80342110
86JAK20.79299389
87UHMK10.79114058
88DYRK20.77600226
89JAK10.76730895
90PRKCQ0.76107351
91MARK30.74599824
92MAP3K70.73157777
93MAPKAPK50.72749124
94DAPK20.72483314
95PNCK0.72324811
96CAMK2D0.71490003
97PAK30.71268813
98TRPM70.70840261
99CAMK1D0.70550391
100CDK80.68382645
101RPS6KA40.65986929
102PIM10.65647621
103FER0.64961490
104NTRK20.64093911
105PRKAA20.62736284
106MATK0.61769624
107IRAK30.60841094
108MAP2K40.60753795
109BCKDK0.60323403
110DYRK30.60060400
111ADRBK10.59385916
112SGK10.58956354
113SGK20.58747230
114PRKG10.58230767
115RPS6KA50.57662805
116DYRK1B0.57257330
117SIK30.56096452
118EGFR0.54114205
119STK110.54002671
120CDC42BPA0.53845121
121CSK0.53533727
122DYRK1A0.53511808
123TGFBR10.51701281
124STK38L0.51492921
125MAP3K40.50788957
126SGK30.50652195
127TYK20.50466635
128GRK50.50346939
129ERBB20.50121686
130MARK10.50064292
131MARK20.49327734
132CAMK10.48721964
133MAPK70.48269582
134PRKACA0.44533124
135OBSCN0.44522450
136TEC0.43935694
137WNK30.43646913
138CSNK1G10.42945118
139FYN0.41364955
140HIPK20.41203074
141NLK0.40982114
142TIE10.40658810
143NME10.39398325
144CSNK1G30.39167484
145CAMK2G0.39150157
146ROCK20.38987957
147IRAK20.37574557
148CDK50.36021029
149TLK10.35689404
150CSNK1G20.35619656

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.80848318
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.70242535
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.64158518
4Fatty acid elongation_Homo sapiens_hsa000622.43989587
5Phototransduction_Homo sapiens_hsa047442.35896556
6Ether lipid metabolism_Homo sapiens_hsa005652.25070772
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.24749593
8Steroid biosynthesis_Homo sapiens_hsa001002.24506376
9Type I diabetes mellitus_Homo sapiens_hsa049402.24255871
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.22553539
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.19115025
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11324627
13Staphylococcus aureus infection_Homo sapiens_hsa051502.01193801
14Asthma_Homo sapiens_hsa053101.93690412
15Taste transduction_Homo sapiens_hsa047421.93095867
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91021770
17Serotonergic synapse_Homo sapiens_hsa047261.85474340
18Leishmaniasis_Homo sapiens_hsa051401.83722623
19Morphine addiction_Homo sapiens_hsa050321.78338972
20Sphingolipid metabolism_Homo sapiens_hsa006001.77288876
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69758558
22Glutamatergic synapse_Homo sapiens_hsa047241.67544064
23Nitrogen metabolism_Homo sapiens_hsa009101.66572548
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.66000470
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59484427
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57599804
27Primary immunodeficiency_Homo sapiens_hsa053401.55447572
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52058272
29Sulfur metabolism_Homo sapiens_hsa009201.44992810
30Fanconi anemia pathway_Homo sapiens_hsa034601.43321272
31Axon guidance_Homo sapiens_hsa043601.41268017
32Arachidonic acid metabolism_Homo sapiens_hsa005901.38890592
33GABAergic synapse_Homo sapiens_hsa047271.38256708
34Linoleic acid metabolism_Homo sapiens_hsa005911.37508579
35Protein export_Homo sapiens_hsa030601.37286376
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35136974
37Systemic lupus erythematosus_Homo sapiens_hsa053221.35134948
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29503916
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.27912978
40Histidine metabolism_Homo sapiens_hsa003401.25174824
41Tuberculosis_Homo sapiens_hsa051521.24449634
42Circadian entrainment_Homo sapiens_hsa047131.21215554
43Retinol metabolism_Homo sapiens_hsa008301.15788201
44Calcium signaling pathway_Homo sapiens_hsa040201.15348081
45Insulin secretion_Homo sapiens_hsa049111.12408626
46Platelet activation_Homo sapiens_hsa046111.12007032
47Propanoate metabolism_Homo sapiens_hsa006401.09944333
48Antigen processing and presentation_Homo sapiens_hsa046121.08054072
49Osteoclast differentiation_Homo sapiens_hsa043801.07205367
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06756503
51Long-term depression_Homo sapiens_hsa047301.05987639
52Salivary secretion_Homo sapiens_hsa049701.04568800
53T cell receptor signaling pathway_Homo sapiens_hsa046601.02062634
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00938345
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00549137
56Renin secretion_Homo sapiens_hsa049240.99226598
57Autoimmune thyroid disease_Homo sapiens_hsa053200.98752075
58Selenocompound metabolism_Homo sapiens_hsa004500.98538964
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.96636526
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.96508905
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95764589
62ABC transporters_Homo sapiens_hsa020100.94560498
63Ovarian steroidogenesis_Homo sapiens_hsa049130.91723619
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91491531
65Tryptophan metabolism_Homo sapiens_hsa003800.90451045
66Peroxisome_Homo sapiens_hsa041460.89745588
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88193756
68Measles_Homo sapiens_hsa051620.87684690
69Rheumatoid arthritis_Homo sapiens_hsa053230.85214800
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84059566
71Ras signaling pathway_Homo sapiens_hsa040140.83664162
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83336184
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83078052
74Amphetamine addiction_Homo sapiens_hsa050310.82787820
75Legionellosis_Homo sapiens_hsa051340.82105818
76Collecting duct acid secretion_Homo sapiens_hsa049660.82046151
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.80851354
78Vitamin digestion and absorption_Homo sapiens_hsa049770.79403395
79cAMP signaling pathway_Homo sapiens_hsa040240.78515899
80Non-homologous end-joining_Homo sapiens_hsa034500.78246032
81beta-Alanine metabolism_Homo sapiens_hsa004100.77645826
82Vitamin B6 metabolism_Homo sapiens_hsa007500.77558610
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76330933
84Melanoma_Homo sapiens_hsa052180.76172429
85Arginine and proline metabolism_Homo sapiens_hsa003300.75661132
86B cell receptor signaling pathway_Homo sapiens_hsa046620.75096737
87Chemical carcinogenesis_Homo sapiens_hsa052040.74086819
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73424565
89RNA degradation_Homo sapiens_hsa030180.72433335
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71685097
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71638542
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70048074
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69608491
94Olfactory transduction_Homo sapiens_hsa047400.68695047
95Dopaminergic synapse_Homo sapiens_hsa047280.68235441
96Toxoplasmosis_Homo sapiens_hsa051450.67493607
97Cocaine addiction_Homo sapiens_hsa050300.67424169
98* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66281303
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64554869
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64514757
101Cholinergic synapse_Homo sapiens_hsa047250.63378174
102Chemokine signaling pathway_Homo sapiens_hsa040620.62140994
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.61036905
104Pancreatic secretion_Homo sapiens_hsa049720.59701595
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58259103
106Type II diabetes mellitus_Homo sapiens_hsa049300.57361304
107Dilated cardiomyopathy_Homo sapiens_hsa054140.56262359
108ECM-receptor interaction_Homo sapiens_hsa045120.56093786
109Alcoholism_Homo sapiens_hsa050340.55145585
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54686924
111Wnt signaling pathway_Homo sapiens_hsa043100.54348332
112Viral myocarditis_Homo sapiens_hsa054160.52881355
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52359743
114Oxytocin signaling pathway_Homo sapiens_hsa049210.52147707
115Influenza A_Homo sapiens_hsa051640.51507489
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51195985
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.51080504
118Pertussis_Homo sapiens_hsa051330.50214470
119Circadian rhythm_Homo sapiens_hsa047100.49533000
120Oxidative phosphorylation_Homo sapiens_hsa001900.49438832
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48350209
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.48035168
123Butanoate metabolism_Homo sapiens_hsa006500.47791934
124Hematopoietic cell lineage_Homo sapiens_hsa046400.47773976
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47378787
126Graft-versus-host disease_Homo sapiens_hsa053320.47294083
127Herpes simplex infection_Homo sapiens_hsa051680.47046011
128Gastric acid secretion_Homo sapiens_hsa049710.47001710
129Regulation of autophagy_Homo sapiens_hsa041400.46778321
130African trypanosomiasis_Homo sapiens_hsa051430.46076685
131Other glycan degradation_Homo sapiens_hsa005110.45261758
132Vibrio cholerae infection_Homo sapiens_hsa051100.44773494
133Dorso-ventral axis formation_Homo sapiens_hsa043200.43985001
134Inositol phosphate metabolism_Homo sapiens_hsa005620.42800061
135Mineral absorption_Homo sapiens_hsa049780.42701213
136Long-term potentiation_Homo sapiens_hsa047200.42664737
137Phagosome_Homo sapiens_hsa041450.42478011
138MAPK signaling pathway_Homo sapiens_hsa040100.41971488
139Hedgehog signaling pathway_Homo sapiens_hsa043400.41554412
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41327086
141Malaria_Homo sapiens_hsa051440.39954492
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38553784
143Allograft rejection_Homo sapiens_hsa053300.37887293

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