UVSSA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene appears to be involved in ubiquitination and dephosphorylation of RNA polymerase II subunits that stall after UV irradiation. The encoded protein interacts with several members of the nucleotide excision repair complex, and is thought to be involved in the transcription-coupled nucleotide excision repair (TC-NER) pathway to help remove lesions in the DNA that block transcription. Defects in this gene can cause UV-sensitive syndrome 3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesenchymal cell differentiation involved in kidney development (GO:0072161)4.65407058
2mesenchymal cell differentiation involved in renal system development (GO:2001012)4.65407058
3cell differentiation involved in metanephros development (GO:0072202)4.19755464
4histone H3-K4 trimethylation (GO:0080182)4.09368723
5activated T cell proliferation (GO:0050798)4.03204905
6regulation of B cell receptor signaling pathway (GO:0050855)4.00700578
7definitive hemopoiesis (GO:0060216)3.71011153
8positive regulation of gamma-delta T cell activation (GO:0046645)3.61644187
9signal peptide processing (GO:0006465)3.59188384
10regulation of male gonad development (GO:2000018)3.58119860
11poly(A)+ mRNA export from nucleus (GO:0016973)3.55482407
12intraciliary transport (GO:0042073)3.54897998
13regulation of hexokinase activity (GO:1903299)3.54660111
14regulation of glucokinase activity (GO:0033131)3.54660111
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54305739
16negative regulation of keratinocyte proliferation (GO:0010839)3.51065273
17establishment of protein localization to Golgi (GO:0072600)3.49861570
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.38501007
19regulation of gamma-delta T cell activation (GO:0046643)3.33837425
20histone H3-K36 demethylation (GO:0070544)3.32490261
21respiratory chain complex IV assembly (GO:0008535)3.26425557
22dendritic cell chemotaxis (GO:0002407)3.20695747
23mannosylation (GO:0097502)3.17018564
24cellular response to ethanol (GO:0071361)3.16585482
25replicative senescence (GO:0090399)3.16012081
26regulation of gamma-delta T cell differentiation (GO:0045586)3.15476978
27androgen biosynthetic process (GO:0006702)3.13731717
28monoubiquitinated protein deubiquitination (GO:0035520)3.11803296
29interferon-gamma production (GO:0032609)3.10933356
30negative regulation of mast cell activation (GO:0033004)3.10240453
31negative thymic T cell selection (GO:0045060)3.09946619
32omega-hydroxylase P450 pathway (GO:0097267)3.08923320
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.08670730
34regulation of translation, ncRNA-mediated (GO:0045974)3.08670730
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08670730
36negative T cell selection (GO:0043383)3.03062025
37Golgi to endosome transport (GO:0006895)3.00657974
38positive regulation of male gonad development (GO:2000020)2.98383068
39ER overload response (GO:0006983)2.96810604
40protein targeting to Golgi (GO:0000042)2.96389381
41protein K11-linked deubiquitination (GO:0035871)2.93442777
42positive regulation of histone deacetylation (GO:0031065)2.90581724
43response to redox state (GO:0051775)2.90437407
44cellular extravasation (GO:0045123)2.89819995
45centriole assembly (GO:0098534)2.86771833
46limb development (GO:0060173)2.84838112
47appendage development (GO:0048736)2.84838112
48cell differentiation involved in kidney development (GO:0061005)2.84811005
49mesenchymal cell differentiation (GO:0048762)2.82485472
50positive regulation of granulocyte differentiation (GO:0030854)2.80016686
51energy homeostasis (GO:0097009)2.77880532
52retrograde transport, vesicle recycling within Golgi (GO:0000301)2.77311758
53cytochrome complex assembly (GO:0017004)2.76843017
54negative regulation of phagocytosis (GO:0050765)2.75022829
55regulation of nuclear cell cycle DNA replication (GO:0033262)2.73731485
56photoreceptor cell maintenance (GO:0045494)2.72393404
57negative regulation of myoblast differentiation (GO:0045662)2.72341324
58extracellular regulation of signal transduction (GO:1900115)2.72292832
59extracellular negative regulation of signal transduction (GO:1900116)2.72292832
60positive T cell selection (GO:0043368)2.71253014
61T cell selection (GO:0045058)2.68620612
62phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.68538313
63histone H3-K9 modification (GO:0061647)2.68406841
64dendritic cell migration (GO:0036336)2.67394003
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66701272
66negative regulation of cell killing (GO:0031342)2.66701272
67histone H3-K9 methylation (GO:0051567)2.65512870
68positive regulation of protein deacetylation (GO:0090312)2.65221825
69DNA dealkylation (GO:0035510)2.64650217
70regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.64109237
71regulation of memory T cell differentiation (GO:0043380)2.64052297
72positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63965787
73regulation of RIG-I signaling pathway (GO:0039535)2.63439380
74interkinetic nuclear migration (GO:0022027)2.61096615
75regulation of granulocyte differentiation (GO:0030852)2.60397416
76positive regulation of T cell chemotaxis (GO:0010820)2.60319146
77regulation of T cell chemotaxis (GO:0010819)2.60319146
78nucleotide transmembrane transport (GO:1901679)2.60190123
79centriole replication (GO:0007099)2.59984877
80eye photoreceptor cell differentiation (GO:0001754)2.59818755
81photoreceptor cell differentiation (GO:0046530)2.59818755
82B cell receptor signaling pathway (GO:0050853)2.58945184
83nucleoside diphosphate catabolic process (GO:0009134)2.57881505
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57455965
85GPI anchor biosynthetic process (GO:0006506)2.57307424
86negative regulation of skeletal muscle tissue development (GO:0048642)2.55773109
87purinergic nucleotide receptor signaling pathway (GO:0035590)2.55026670
88DNA methylation involved in gamete generation (GO:0043046)2.54652552
89toxin transport (GO:1901998)2.54596892
90glucosamine-containing compound catabolic process (GO:1901072)2.54450352
91glomerulus development (GO:0032835)2.54021495
92mannose metabolic process (GO:0006013)2.53727444
93preassembly of GPI anchor in ER membrane (GO:0016254)2.53077127
94regulation of fibroblast apoptotic process (GO:2000269)2.51607388
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51388364
96negative regulation of protein oligomerization (GO:0032460)2.51025145
97presynaptic membrane assembly (GO:0097105)2.50955351
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.50798313
99RNA-dependent DNA replication (GO:0006278)2.50389465
100cellular response to gamma radiation (GO:0071480)2.50286835
101cellular response to exogenous dsRNA (GO:0071360)2.49789675
102tolerance induction (GO:0002507)2.49566349
103negative regulation of interleukin-8 production (GO:0032717)2.48839418
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47372643
105positive regulation by organism of defense response of other organism involved in symbiotic interact2.47372643
106modulation by symbiont of host immune response (GO:0052553)2.47372643
107positive regulation by symbiont of host defense response (GO:0052509)2.47372643
108modulation by symbiont of host defense response (GO:0052031)2.47372643
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47372643
110regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47185893
111negative regulation of calcium ion transport into cytosol (GO:0010523)2.47155263
112positive regulation of CREB transcription factor activity (GO:0032793)2.46815385
113regulation of cell proliferation involved in kidney development (GO:1901722)2.45626723
114peptidyl-lysine methylation (GO:0018022)2.45202665
115positive regulation of T cell migration (GO:2000406)2.44727496
116CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.44624186
117fucose catabolic process (GO:0019317)2.44092372
118L-fucose metabolic process (GO:0042354)2.44092372
119L-fucose catabolic process (GO:0042355)2.44092372
120adaptation of signaling pathway (GO:0023058)2.44073948
121regulation of histone H3-K27 methylation (GO:0061085)2.43743199
122negative regulation of T-helper cell differentiation (GO:0045623)2.41457592
123negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.41457592
124positive regulation of defense response to virus by host (GO:0002230)2.41415036
125cilium or flagellum-dependent cell motility (GO:0001539)2.41322973
126negative regulation of transcription by competitive promoter binding (GO:0010944)2.39507100
127histone lysine methylation (GO:0034968)2.38956159
128sulfate transmembrane transport (GO:1902358)2.38579437
129regulation of interferon-beta biosynthetic process (GO:0045357)2.38050890
130piRNA metabolic process (GO:0034587)2.37961406
131lipid translocation (GO:0034204)2.37562869
132phospholipid translocation (GO:0045332)2.37562869
133pyrimidine dimer repair (GO:0006290)2.37175834
134dentate gyrus development (GO:0021542)2.36690193
135histone demethylation (GO:0016577)2.35819998
136negative regulation of T cell mediated immunity (GO:0002710)2.35694797
137regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35365309
138negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.35138397
139metanephric mesenchyme development (GO:0072075)2.34388838
140regulation of interleukin-8 secretion (GO:2000482)2.34020359
141histone lysine demethylation (GO:0070076)2.33879964
142tachykinin receptor signaling pathway (GO:0007217)2.33876495
143peptidyl-lysine trimethylation (GO:0018023)2.33733404
144regulation of interleukin-12 biosynthetic process (GO:0045075)2.33505896
145GPI anchor metabolic process (GO:0006505)2.33402859
146negative regulation of lymphocyte mediated immunity (GO:0002707)2.33400022
147regulation of MHC class I biosynthetic process (GO:0045343)2.32138621
148neutrophil mediated immunity (GO:0002446)2.32097705
149megakaryocyte development (GO:0035855)2.31616143
150histone H3-K4 methylation (GO:0051568)2.31568602
151protein localization to Golgi apparatus (GO:0034067)2.31173900
152protein K63-linked deubiquitination (GO:0070536)2.30994093
153glycosphingolipid catabolic process (GO:0046479)2.30107874
154regulation of MHC class II biosynthetic process (GO:0045346)2.29997223
155macrophage activation involved in immune response (GO:0002281)2.28650184
156response to interleukin-15 (GO:0070672)2.28623499
157adenosine metabolic process (GO:0046085)2.28285656
158regulation of regulatory T cell differentiation (GO:0045589)2.28126867
159regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.27940217
160oligosaccharide catabolic process (GO:0009313)2.27723974
161axoneme assembly (GO:0035082)2.27533291
162RNA destabilization (GO:0050779)2.26900726
163cell proliferation involved in kidney development (GO:0072111)2.26883923
164cilium assembly (GO:0042384)2.26776915
165neural tube formation (GO:0001841)2.26017461
166negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.25793595
167leukocyte aggregation (GO:0070486)2.25732751
168positive thymic T cell selection (GO:0045059)2.25539155
169inner ear receptor cell differentiation (GO:0060113)2.25463381
170detection of other organism (GO:0098543)2.25289329
171regulation of interleukin-6 biosynthetic process (GO:0045408)2.25164497
172oxidative demethylation (GO:0070989)2.24943225
173mesonephros development (GO:0001823)2.24559755
174C-terminal protein lipidation (GO:0006501)2.24093165
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.23955368
176androgen metabolic process (GO:0008209)2.23830767
177negative regulation of cAMP-mediated signaling (GO:0043951)2.23348829
178negative regulation of Rho protein signal transduction (GO:0035024)2.23199539
179regulation of female gonad development (GO:2000194)2.23036257
180regulation of germinal center formation (GO:0002634)2.22928546
181sister chromatid cohesion (GO:0007062)2.22880284
182ganglion development (GO:0061548)2.22833166
183negative regulation of adaptive immune response (GO:0002820)2.22436457
184regulation of B cell differentiation (GO:0045577)2.20593500
185antigen processing and presentation of endogenous antigen (GO:0019883)2.19593002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97189617
2PCGF2_27294783_Chip-Seq_ESCs_Mouse2.94535797
3FLI1_27457419_Chip-Seq_LIVER_Mouse2.87615619
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64809946
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61214719
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56847836
7SUZ12_27294783_Chip-Seq_NPCs_Mouse2.40641233
8GBX2_23144817_ChIP-Seq_PC3_Human2.34764987
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31174163
10NFE2_27457419_Chip-Seq_LIVER_Mouse2.28207772
11ZNF274_21170338_ChIP-Seq_K562_Hela2.25783576
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.16962830
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16880086
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.14903700
15EZH2_27294783_Chip-Seq_NPCs_Mouse2.12423476
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.11205915
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10135914
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09668212
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06568781
20NANOG_18555785_Chip-Seq_ESCs_Mouse1.95950322
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95845101
22P53_22387025_ChIP-Seq_ESCs_Mouse1.95389777
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.95119216
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93004344
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.92509548
26SUZ12_18555785_Chip-Seq_ESCs_Mouse1.89995536
27E2F1_18555785_Chip-Seq_ESCs_Mouse1.87601622
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.86127885
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85176377
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83263643
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.82523851
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.80242324
33SCL_19346495_ChIP-Seq_HPC-7_Human1.79507036
34NMYC_18555785_Chip-Seq_ESCs_Mouse1.78335427
35EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77174242
36VDR_24787735_ChIP-Seq_THP-1_Human1.75396453
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72528809
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69842654
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67733387
40P300_18555785_Chip-Seq_ESCs_Mouse1.66673241
41IRF1_19129219_ChIP-ChIP_H3396_Human1.66328493
42FUS_26573619_Chip-Seq_HEK293_Human1.65884504
43EWS_26573619_Chip-Seq_HEK293_Human1.65833537
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.64747804
45RUNX1_27457419_Chip-Seq_LIVER_Mouse1.63652571
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62886908
47CMYC_18555785_Chip-Seq_ESCs_Mouse1.61988348
48P300_19829295_ChIP-Seq_ESCs_Human1.61617055
49BCAT_22108803_ChIP-Seq_LS180_Human1.60143280
50VDR_22108803_ChIP-Seq_LS180_Human1.60042173
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59768136
52OCT4_18555785_Chip-Seq_ESCs_Mouse1.57952644
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.55717321
54ZFX_18555785_Chip-Seq_ESCs_Mouse1.51764742
55PU1_27457419_Chip-Seq_LIVER_Mouse1.50943506
56TAF15_26573619_Chip-Seq_HEK293_Human1.50292099
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.49878291
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.49576109
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49154708
60KLF4_18555785_Chip-Seq_ESCs_Mouse1.48117777
61DROSHA_22980978_ChIP-Seq_HELA_Human1.40434019
62SMAD4_21799915_ChIP-Seq_A2780_Human1.38986839
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38179040
64AR_21572438_ChIP-Seq_LNCaP_Human1.37590925
65CTCF_18555785_Chip-Seq_ESCs_Mouse1.37215176
66ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36340904
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34956529
68SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34822785
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34334903
70MYB_26560356_Chip-Seq_TH2_Human1.34289251
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.34065131
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33998908
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32035391
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.31769676
75GATA3_27048872_Chip-Seq_THYMUS_Human1.30237256
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29536437
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28732058
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28520339
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28310815
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28175380
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28024295
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.27832958
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26601307
84RNF2_27304074_Chip-Seq_NSC_Mouse1.26503784
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26063865
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25420238
87GATA3_26560356_Chip-Seq_TH2_Human1.25337506
88TP53_16413492_ChIP-PET_HCT116_Human1.23792550
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.22648879
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.21992103
91RUNX_20019798_ChIP-Seq_JUKART_Human1.21889793
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21032988
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.20495267
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19482594
95GATA1_22025678_ChIP-Seq_K562_Human1.19437857
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19150628
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17572491
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17572491
99STAT3_23295773_ChIP-Seq_U87_Human1.17537088
100SMRT_27268052_Chip-Seq_Bcells_Human1.16629435
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.16403699
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.16346594
103MYB_26560356_Chip-Seq_TH1_Human1.16321331
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15368151
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15118294
106SPI1_23127762_ChIP-Seq_K562_Human1.14475589
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14132631
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13161804
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.12348002
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12213762
111AHR_22903824_ChIP-Seq_MCF-7_Human1.11737953
112TCF4_23295773_ChIP-Seq_U87_Human1.11602277
113ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11161939
114GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10981696
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10722771
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10399570
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.10389246
118ER_23166858_ChIP-Seq_MCF-7_Human1.09990760
119AR_25329375_ChIP-Seq_VCAP_Human1.08942334
120RUNX2_22187159_ChIP-Seq_PCA_Human1.07783599
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07572282
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06222324
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06158942
124IGF1R_20145208_ChIP-Seq_DFB_Human1.05864095
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05852673
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05548631
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05321408
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05162354
129TCF4_22108803_ChIP-Seq_LS180_Human1.04200035
130FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03284929
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02642824
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02233500
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02102476
134CBP_20019798_ChIP-Seq_JUKART_Human1.01666924
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01666924
136CDX2_22108803_ChIP-Seq_LS180_Human1.01651346
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01014852
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00453351
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.99685369
140KDM2B_26808549_Chip-Seq_REH_Human0.99428635
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97478890
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97258179
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97189619
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97076679
145TP53_22573176_ChIP-Seq_HFKS_Human0.95896736
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95606856
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94023246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.78584596
2MP0006292_abnormal_olfactory_placode3.73704162
3MP0000015_abnormal_ear_pigmentation2.81291812
4MP0003172_abnormal_lysosome_physiology2.75131860
5MP0003787_abnormal_imprinting2.69006427
6MP0005646_abnormal_pituitary_gland2.50685649
7MP0001835_abnormal_antigen_presentation2.45174548
8MP0000566_synostosis2.41147625
9MP0002876_abnormal_thyroid_physiology2.41022839
10MP0003195_calcinosis2.40763022
11MP0001986_abnormal_taste_sensitivity2.37905144
12MP0009697_abnormal_copulation2.33432397
13MP0005171_absent_coat_pigmentation2.32999933
14MP0000685_abnormal_immune_system2.26856392
15MP0005310_abnormal_salivary_gland2.25082410
16MP0004782_abnormal_surfactant_physiolog2.23581337
17MP0001873_stomach_inflammation2.19085310
18MP0003941_abnormal_skin_development2.18259446
19MP0005075_abnormal_melanosome_morpholog2.07917526
20MP0008877_abnormal_DNA_methylation2.07395311
21MP0005409_darkened_coat_color2.05222827
22MP0002877_abnormal_melanocyte_morpholog1.97495612
23MP0002254_reproductive_system_inflammat1.97358677
24MP0002638_abnormal_pupillary_reflex1.95471941
25MP0003436_decreased_susceptibility_to1.95106144
26MP0005379_endocrine/exocrine_gland_phen1.92977273
27MP0002009_preneoplasia1.86713942
28MP0005174_abnormal_tail_pigmentation1.83946492
29MP0010386_abnormal_urinary_bladder1.83309310
30MP0008057_abnormal_DNA_replication1.83027186
31MP0002095_abnormal_skin_pigmentation1.73869648
32MP0005000_abnormal_immune_tolerance1.67796058
33MP0003045_fibrosis1.67242345
34MP0003763_abnormal_thymus_physiology1.67151277
35MP0002405_respiratory_system_inflammati1.67086028
36MP0000372_irregular_coat_pigmentation1.66831347
37MP0002938_white_spotting1.61312113
38MP0005671_abnormal_response_to1.54946758
39MP0008007_abnormal_cellular_replicative1.54517087
40MP0005025_abnormal_response_to1.51131579
41MP0008789_abnormal_olfactory_epithelium1.50860397
42MP0002928_abnormal_bile_duct1.49679354
43MP0009278_abnormal_bone_marrow1.49634520
44MP0002163_abnormal_gland_morphology1.48747901
45MP0005408_hypopigmentation1.48148433
46MP0002166_altered_tumor_susceptibility1.45022087
47MP0003646_muscle_fatigue1.44259211
48MP0005503_abnormal_tendon_morphology1.43198023
49MP0003943_abnormal_hepatobiliary_system1.42552131
50MP0008058_abnormal_DNA_repair1.40785679
51MP0001502_abnormal_circadian_rhythm1.39909591
52MP0000716_abnormal_immune_system1.37539149
53MP0000383_abnormal_hair_follicle1.36096139
54MP0003183_abnormal_peptide_metabolism1.35460605
55MP0000569_abnormal_digit_pigmentation1.33204830
56MP0001984_abnormal_olfaction1.32695751
57MP0001186_pigmentation_phenotype1.32458343
58MP0003136_yellow_coat_color1.27971943
59MP0000689_abnormal_spleen_morphology1.27423128
60MP0005499_abnormal_olfactory_system1.27142777
61MP0005394_taste/olfaction_phenotype1.27142777
62MP0001177_atelectasis1.25567734
63MP0001119_abnormal_female_reproductive1.24362988
64MP0005387_immune_system_phenotype1.22787097
65MP0001790_abnormal_immune_system1.22787097
66MP0002277_abnormal_respiratory_mucosa1.22603235
67MP0000371_diluted_coat_color1.21684429
68MP0004043_abnormal_pH_regulation1.21004574
69MP0002933_joint_inflammation1.20289248
70MP0002168_other_aberrant_phenotype1.20015248
71MP0001919_abnormal_reproductive_system1.19538942
72MP0000681_abnormal_thyroid_gland1.19206302
73MP0002132_abnormal_respiratory_system1.19014570
74MP0000678_abnormal_parathyroid_gland1.18861840
75MP0001501_abnormal_sleep_pattern1.17129891
76MP0001879_abnormal_lymphatic_vessel1.17047412
77MP0006082_CNS_inflammation1.15336249
78MP0001764_abnormal_homeostasis1.14911427
79MP0005084_abnormal_gallbladder_morpholo1.13709843
80MP0005645_abnormal_hypothalamus_physiol1.13508747
81MP0003786_premature_aging1.13039513
82MP0001545_abnormal_hematopoietic_system1.12475253
83MP0005397_hematopoietic_system_phenotyp1.12475253
84MP0010155_abnormal_intestine_physiology1.12244941
85MP0005389_reproductive_system_phenotype1.12209249
86MP0002160_abnormal_reproductive_system1.11810171
87MP0000703_abnormal_thymus_morphology1.11758101
88MP0001845_abnormal_inflammatory_respons1.11598792
89MP0002177_abnormal_outer_ear1.09721376
90MP0005220_abnormal_exocrine_pancreas1.09530269
91MP0009764_decreased_sensitivity_to1.08467827
92MP0005551_abnormal_eye_electrophysiolog1.07039349
93MP0001968_abnormal_touch/_nociception1.04430220
94MP0002722_abnormal_immune_system1.03886540
95MP0009785_altered_susceptibility_to1.03741450
96MP0002148_abnormal_hypersensitivity_rea1.03608010
97MP0008961_abnormal_basal_metabolism1.01070857
98MP0005464_abnormal_platelet_physiology1.00490126
99MP0009250_abnormal_appendicular_skeleto1.00401863
100MP0003279_aneurysm1.00220498
101MP0000631_abnormal_neuroendocrine_gland0.99748327
102MP0002075_abnormal_coat/hair_pigmentati0.99136370
103MP0004808_abnormal_hematopoietic_stem0.99079494
104MP0000427_abnormal_hair_cycle0.98789612
105MP0008995_early_reproductive_senescence0.98654503
106MP0002429_abnormal_blood_cell0.97714587
107MP0001324_abnormal_eye_pigmentation0.95501773
108MP0010329_abnormal_lipoprotein_level0.95360934
109MP0004484_altered_response_of0.95341603
110MP0002006_tumorigenesis0.94866202
111MP0001270_distended_abdomen0.94801991
112MP0010678_abnormal_skin_adnexa0.93427809
113MP0001800_abnormal_humoral_immune0.92958576
114MP0002419_abnormal_innate_immunity0.92471897
115MP0005647_abnormal_sex_gland0.91899926
116MP0002420_abnormal_adaptive_immunity0.90846047
117MP0002396_abnormal_hematopoietic_system0.89530296
118MP0001819_abnormal_immune_cell0.89166822
119MP0002452_abnormal_antigen_presenting0.88158351
120MP0005253_abnormal_eye_physiology0.87950199
121MP0004947_skin_inflammation0.87714612
122MP0000049_abnormal_middle_ear0.87487711
123MP0003121_genomic_imprinting0.87099032
124MP0003300_gastrointestinal_ulcer0.86984910
125MP0004883_abnormal_blood_vessel0.86714667
126MP0009333_abnormal_splenocyte_physiolog0.86047731
127MP0003303_peritoneal_inflammation0.85972696
128MP0005167_abnormal_blood-brain_barrier0.85303487
129MP0002693_abnormal_pancreas_physiology0.84317699
130MP0002109_abnormal_limb_morphology0.83691946
131MP0000516_abnormal_urinary_system0.82550307
132MP0005367_renal/urinary_system_phenotyp0.82550307
133MP0001533_abnormal_skeleton_physiology0.81795309
134MP0002249_abnormal_larynx_morphology0.80972599
135MP0008872_abnormal_physiological_respon0.79892617
136MP0004147_increased_porphyrin_level0.79600284
137MP0009379_abnormal_foot_pigmentation0.79367886
138MP0000538_abnormal_urinary_bladder0.78811488
139MP0000613_abnormal_salivary_gland0.78440516
140MP0002138_abnormal_hepatobiliary_system0.78327734
141MP0003828_pulmonary_edema0.77756402
142MP0008469_abnormal_protein_level0.77377236
143MP0002398_abnormal_bone_marrow0.77226916
144MP0003724_increased_susceptibility_to0.76875743
145MP0006054_spinal_hemorrhage0.75780378
146MP0003252_abnormal_bile_duct0.75766394
147MP0000230_abnormal_systemic_arterial0.74528687
148MP0002723_abnormal_immune_serum0.74513942
149MP0006072_abnormal_retinal_apoptosis0.73083323
150MP0001663_abnormal_digestive_system0.71993056
151MP0004381_abnormal_hair_follicle0.70647240
152MP0009115_abnormal_fat_cell0.70099461
153MP0003866_abnormal_defecation0.69062717
154MP0005448_abnormal_energy_balance0.68785700

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.07842648
2Abnormal hair whorl (HP:0010721)3.76856040
3True hermaphroditism (HP:0010459)3.60509593
4Hypothermia (HP:0002045)3.51368335
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33528969
6Lip pit (HP:0100267)3.28393256
7Type I transferrin isoform profile (HP:0003642)3.22647325
8Chromsome breakage (HP:0040012)3.18785401
9Abnormality of incisor morphology (HP:0011063)3.15788277
10Chronic hepatic failure (HP:0100626)3.07053901
11Myositis (HP:0100614)3.04869023
12Orchitis (HP:0100796)3.04538203
13Recurrent fungal infections (HP:0002841)3.00989964
14Abnormality of the fingertips (HP:0001211)2.93117425
15Attenuation of retinal blood vessels (HP:0007843)2.88730728
16Abnormal delayed hypersensitivity skin test (HP:0002963)2.88287517
17Pancreatic fibrosis (HP:0100732)2.86287534
18Renal cortical cysts (HP:0000803)2.79841637
19Stomach cancer (HP:0012126)2.79511366
20Hyperventilation (HP:0002883)2.72715160
21Widely spaced teeth (HP:0000687)2.72397827
22Genetic anticipation (HP:0003743)2.69601288
23Congenital stationary night blindness (HP:0007642)2.69370543
24Agammaglobulinemia (HP:0004432)2.65236266
25Hemoptysis (HP:0002105)2.64763373
26Pustule (HP:0200039)2.63885668
27Abnormality of the nasal septum (HP:0000419)2.63523919
28Eczematoid dermatitis (HP:0000976)2.61152002
29Pancreatic cysts (HP:0001737)2.59036696
30Elevated erythrocyte sedimentation rate (HP:0003565)2.55817807
31Keratoconjunctivitis (HP:0001096)2.51192898
32Tubulointerstitial nephritis (HP:0001970)2.49077496
33Patchy hypopigmentation of hair (HP:0011365)2.48636167
34Osteomalacia (HP:0002749)2.48298640
35Clumsiness (HP:0002312)2.45404868
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.44354175
37Hypoplasia of the fovea (HP:0007750)2.44354175
38Protruding tongue (HP:0010808)2.43662142
39Gastrointestinal infarctions (HP:0005244)2.43638305
40White forelock (HP:0002211)2.43078737
41Alveolar cell carcinoma (HP:0006519)2.39257245
42Abnormality of the renal cortex (HP:0011035)2.38591911
43Fibular hypoplasia (HP:0003038)2.37377349
44Molar tooth sign on MRI (HP:0002419)2.36369028
45Abnormality of midbrain morphology (HP:0002418)2.36369028
46Recurrent skin infections (HP:0001581)2.33090314
47Vasculitis (HP:0002633)2.30186911
48Type II lissencephaly (HP:0007260)2.29422335
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29378614
50Gaze-evoked nystagmus (HP:0000640)2.29102174
51Abnormality of the renal medulla (HP:0100957)2.29051963
52Chronic mucocutaneous candidiasis (HP:0002728)2.28062880
53Recurrent cutaneous fungal infections (HP:0011370)2.28062880
54Tubular atrophy (HP:0000092)2.27039121
55Medial flaring of the eyebrow (HP:0010747)2.23959261
56Nephronophthisis (HP:0000090)2.22984283
57Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.21437162
58Keratoconjunctivitis sicca (HP:0001097)2.21380446
59Asymmetry of the thorax (HP:0001555)2.20626341
60Absent speech (HP:0001344)2.18453313
61Submucous cleft hard palate (HP:0000176)2.17775816
62Cystic liver disease (HP:0006706)2.16457943
63Fair hair (HP:0002286)2.15799788
64Neonatal hypoglycemia (HP:0001998)2.15179115
65Recurrent bacterial skin infections (HP:0005406)2.14996462
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14945605
67Abnormal protein N-linked glycosylation (HP:0012347)2.14945605
68Abnormal protein glycosylation (HP:0012346)2.14945605
69Abnormal glycosylation (HP:0012345)2.14945605
70Clubbing of toes (HP:0100760)2.14261615
71Polydipsia (HP:0001959)2.13421118
72Abnormal drinking behavior (HP:0030082)2.13421118
73Postaxial foot polydactyly (HP:0001830)2.12766517
74Abnormality of T cell physiology (HP:0011840)2.10938627
75Abnormality of the renal collecting system (HP:0004742)2.10869814
76Panhypogammaglobulinemia (HP:0003139)2.10624747
77Meningitis (HP:0001287)2.09219963
78Abolished electroretinogram (ERG) (HP:0000550)2.08961320
79Pulmonary infiltrates (HP:0002113)2.07765845
80Abnormality of T cell number (HP:0011839)2.07384446
81Abnormality of the fovea (HP:0000493)2.05374645
82Nephroblastoma (Wilms tumor) (HP:0002667)2.05328639
83Poor coordination (HP:0002370)2.03661722
84Type 2 muscle fiber atrophy (HP:0003554)2.03482905
85Hematochezia (HP:0002573)2.02985790
86Enlarged kidneys (HP:0000105)2.02881550
87Abnormality of T cells (HP:0002843)2.00467085
88Intestinal atresia (HP:0011100)2.00179533
89Keratitis (HP:0000491)1.99899060
90Neoplasm of the tracheobronchial system (HP:0100552)1.99847727
91Prolonged bleeding time (HP:0003010)1.99797296
92Nephrogenic diabetes insipidus (HP:0009806)1.99781889
93Abnormal rod and cone electroretinograms (HP:0008323)1.99139612
94Reduced antithrombin III activity (HP:0001976)1.98914236
95Bile duct proliferation (HP:0001408)1.98814852
96Abnormal biliary tract physiology (HP:0012439)1.98814852
97Aplastic anemia (HP:0001915)1.98594209
98Neoplasm of the adrenal cortex (HP:0100641)1.98146370
99T lymphocytopenia (HP:0005403)1.97774645
100Chest pain (HP:0100749)1.97015105
101Bony spicule pigmentary retinopathy (HP:0007737)1.96321659
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94286787
103Arterial thrombosis (HP:0004420)1.92676670
104Thyroid-stimulating hormone excess (HP:0002925)1.92578931
105Abnormality of the columella (HP:0009929)1.92268818
106Prostate neoplasm (HP:0100787)1.91474069
107Embryonal renal neoplasm (HP:0011794)1.91138143
108Renal dysplasia (HP:0000110)1.89708027
109Tented upper lip vermilion (HP:0010804)1.89383097
110Optic neuritis (HP:0100653)1.89363951
111Retrobulbar optic neuritis (HP:0100654)1.89363951
112Congenital primary aphakia (HP:0007707)1.89267670
113Episodic fever (HP:0001954)1.89128388
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88499204
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87293220
116Ectopic kidney (HP:0000086)1.86928542
117Generalized hypopigmentation of hair (HP:0011358)1.86718923
118Abnormality of the prostate (HP:0008775)1.86614466
119Abnormality of the frontal sinuses (HP:0002687)1.84663330
120Febrile seizures (HP:0002373)1.84159908
121Congenital sensorineural hearing impairment (HP:0008527)1.83809230
122Recurrent abscess formation (HP:0002722)1.83715577
123Median cleft lip (HP:0000161)1.83350808
124Optic nerve coloboma (HP:0000588)1.82810580
125Recurrent sinusitis (HP:0011108)1.82749047
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.82599168
127Hyperkalemia (HP:0002153)1.81936286
128Abnormality of the right ventricle (HP:0001707)1.80091580
129Recurrent bronchitis (HP:0002837)1.79450811
130Pulmonary embolism (HP:0002204)1.78744685
131Mediastinal lymphadenopathy (HP:0100721)1.75927579
132Decreased circulating renin level (HP:0003351)1.75432920
133Cheilitis (HP:0100825)1.75126776
134Preaxial hand polydactyly (HP:0001177)1.74530359
135Encephalitis (HP:0002383)1.73738291
136Renal tubular dysfunction (HP:0000124)1.73461658
137Abnormality of male internal genitalia (HP:0000022)1.73021066
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.72824242
139Hypochromic anemia (HP:0001931)1.72716100
140Chronic diarrhea (HP:0002028)1.71982471
141Gait imbalance (HP:0002141)1.71909129
142Syringomyelia (HP:0003396)1.71466282
143Spinal cord lesions (HP:0100561)1.71466282
144Deep philtrum (HP:0002002)1.70999101
145Papillary thyroid carcinoma (HP:0002895)1.70923552
146Progressive cerebellar ataxia (HP:0002073)1.70886570
147Abnormality of chromosome stability (HP:0003220)1.70069866
148Nasolacrimal duct obstruction (HP:0000579)1.68231926
149Abnormal respiratory motile cilium physiology (HP:0012261)1.68044193
150Male pseudohermaphroditism (HP:0000037)1.67263385
151Constricted visual fields (HP:0001133)1.66607619
152Severe visual impairment (HP:0001141)1.66491935
153Volvulus (HP:0002580)1.66128105
154Occipital encephalocele (HP:0002085)1.66006687
155Abnormal ciliary motility (HP:0012262)1.65454337
156Abnormality of the preputium (HP:0100587)1.65204489
157Spontaneous hematomas (HP:0007420)1.65143931
158Large for gestational age (HP:0001520)1.65127662
159Nephropathy (HP:0000112)1.64343209
160Abnormality of renal resorption (HP:0011038)1.63924915
161Bifid tongue (HP:0010297)1.63559814
162Aplasia/Hypoplasia of the lens (HP:0008063)1.63305733
163Absent eyebrow (HP:0002223)1.62972623
164Recurrent pneumonia (HP:0006532)1.62952330
165Macroorchidism (HP:0000053)1.61784637
166Thyroiditis (HP:0100646)1.61602988
167Broad alveolar ridges (HP:0000187)1.61138357
168Tapered finger (HP:0001182)1.60638607
169Congenital hepatic fibrosis (HP:0002612)1.60455078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.96789043
2ZAK3.31266360
3IRAK32.78126749
4INSRR2.73739043
5MKNK22.66714456
6TXK2.53159574
7AKT32.51243625
8IRAK42.49618618
9CASK2.42449341
10SGK22.42353244
11MAP3K142.20573930
12TNIK2.14201599
13BLK2.10925611
14ERBB31.99279136
15BRD41.96284918
16FRK1.92295250
17YES11.85319072
18NUAK11.81739977
19CDK31.78789896
20PIK3CG1.73753659
21MAP3K71.66848251
22BMPR21.66275358
23BMPR1B1.63679116
24TEC1.62009589
25RIPK41.61348429
26MKNK11.59765039
27SGK31.50422358
28TAOK31.49390743
29WNK31.45950485
30SIK31.39942665
31SGK4941.38625142
32SGK2231.38625142
33TNK21.35070216
34SRPK11.34189345
35FGFR21.33154092
36IKBKE1.30644712
37EIF2AK21.28788249
38PTK2B1.28436662
39TRPM71.27405985
40NLK1.25310628
41CHUK1.25120155
42SYK1.21816322
43CAMK1G1.21631332
44FES1.20550183
45NEK61.20013786
46TYK21.19150366
47ITK1.18859348
48GRK11.18842649
49MAP2K71.17323846
50PINK11.16745267
51IRAK11.15708233
52STK38L1.12975607
53TAOK21.09059042
54IKBKB1.08714748
55CDK81.06302054
56MAPK131.03144328
57HCK1.01774689
58SIK21.00425728
59CAMK1D0.98956890
60CSF1R0.97995273
61EIF2AK30.97270385
62MAPK150.94204989
63PIK3CA0.94198431
64GRK60.93511002
65IRAK20.92549452
66CDK120.92382733
67NEK90.91272666
68CSK0.90679475
69STK240.87770545
70JAK30.87485110
71CAMKK20.86958531
72FGFR30.85331911
73DAPK20.84640415
74MAP3K20.84572169
75PLK40.83017645
76ADRBK20.82454924
77STK110.81102769
78CLK10.79599804
79EPHA30.77267305
80KIT0.77106165
81BTK0.76493898
82MUSK0.76447245
83WNK40.75267210
84TIE10.75261920
85MARK30.75152251
86VRK10.74513073
87LCK0.74509379
88MARK20.73848234
89MAP4K10.73651308
90ZAP700.71978803
91GRK70.70705743
92PRKG20.68036193
93FER0.67142868
94HIPK20.66258593
95ACVR1B0.65316966
96TGFBR20.62546504
97BRSK20.61812301
98MAP2K30.61686418
99MAP3K130.61617855
100CDC42BPA0.59410581
101MAPK120.58447077
102MAP3K60.58373310
103MAPK70.58293839
104PIM10.56940983
105ERBB20.56655372
106RPS6KB10.56383001
107MAP3K40.55247841
108PRKCE0.53768568
109PAK30.53145429
110EPHB10.52267281
111STK160.52129095
112PRKAA10.51122942
113TAOK10.50361489
114ADRBK10.50132440
115JAK20.49834499
116PRKCZ0.48875669
117RPS6KA60.47990309
118PRKCH0.47431853
119MAP3K30.46829639
120DYRK1A0.46800179
121JAK10.46075792
122CAMK40.45843504
123FGR0.44862796
124ATR0.44712349
125PRKD20.44504431
126PDK10.44168289
127RPS6KC10.43469558
128RPS6KL10.43469558
129MYLK0.43269658
130PLK30.43138705
131MAP2K60.39685592
132LYN0.39404901
133FLT30.36889404
134PNCK0.36736403
135PRKCQ0.36339833
136TBK10.36123831
137PRKAA20.35891809
138ABL10.35778451
139RPS6KA20.35463989
140IGF1R0.35171814
141SGK10.34396294
142ATM0.33078404
143WNK10.32803334
144CSNK1A1L0.31913886
145MAPK30.31579174

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.11942612
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.49360432
3Primary immunodeficiency_Homo sapiens_hsa053402.39947682
4Fanconi anemia pathway_Homo sapiens_hsa034602.38914661
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22987441
6Dorso-ventral axis formation_Homo sapiens_hsa043202.07706710
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02354455
8Basal transcription factors_Homo sapiens_hsa030221.95404019
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92915979
10Linoleic acid metabolism_Homo sapiens_hsa005911.85075786
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82328521
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.81775002
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.80075922
14Homologous recombination_Homo sapiens_hsa034401.79890247
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75395093
16Non-homologous end-joining_Homo sapiens_hsa034501.71476433
17Circadian rhythm_Homo sapiens_hsa047101.70413383
18Phototransduction_Homo sapiens_hsa047441.68948991
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67243329
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64986272
21Staphylococcus aureus infection_Homo sapiens_hsa051501.63888304
22Arachidonic acid metabolism_Homo sapiens_hsa005901.60479530
23RNA degradation_Homo sapiens_hsa030181.58796635
24Measles_Homo sapiens_hsa051621.57112813
25Other glycan degradation_Homo sapiens_hsa005111.50461094
26Type I diabetes mellitus_Homo sapiens_hsa049401.47720942
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47665202
28Autoimmune thyroid disease_Homo sapiens_hsa053201.40968749
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39156261
30ABC transporters_Homo sapiens_hsa020101.35629362
31Herpes simplex infection_Homo sapiens_hsa051681.34959326
32Sphingolipid metabolism_Homo sapiens_hsa006001.34418127
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32349702
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31939366
35Hematopoietic cell lineage_Homo sapiens_hsa046401.29168799
36Retinol metabolism_Homo sapiens_hsa008301.22176677
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20000918
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19768333
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17365772
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.13122554
41N-Glycan biosynthesis_Homo sapiens_hsa005101.12961324
42Selenocompound metabolism_Homo sapiens_hsa004501.11899492
43Graft-versus-host disease_Homo sapiens_hsa053321.11331568
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.09383382
45Base excision repair_Homo sapiens_hsa034101.05815712
46Allograft rejection_Homo sapiens_hsa053301.05640825
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05466302
48Platelet activation_Homo sapiens_hsa046111.02497307
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.01220720
50Choline metabolism in cancer_Homo sapiens_hsa052311.00195862
51Type II diabetes mellitus_Homo sapiens_hsa049301.00083653
52Tuberculosis_Homo sapiens_hsa051520.99989450
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96379601
54Influenza A_Homo sapiens_hsa051640.96188091
55Peroxisome_Homo sapiens_hsa041460.94705198
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94268860
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93625474
58Caffeine metabolism_Homo sapiens_hsa002320.93282205
59mTOR signaling pathway_Homo sapiens_hsa041500.92353320
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92088814
61Chemical carcinogenesis_Homo sapiens_hsa052040.91717123
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91436716
63Butanoate metabolism_Homo sapiens_hsa006500.90619208
64Regulation of autophagy_Homo sapiens_hsa041400.90510264
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89289664
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89062901
67Prostate cancer_Homo sapiens_hsa052150.88324845
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86448930
69Chemokine signaling pathway_Homo sapiens_hsa040620.85166908
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.84529995
71Insulin resistance_Homo sapiens_hsa049310.84284433
72Taste transduction_Homo sapiens_hsa047420.81632168
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79098982
74Leishmaniasis_Homo sapiens_hsa051400.78665941
75Lysine degradation_Homo sapiens_hsa003100.78513424
76Purine metabolism_Homo sapiens_hsa002300.77557821
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77196949
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74109793
79African trypanosomiasis_Homo sapiens_hsa051430.72507606
80FoxO signaling pathway_Homo sapiens_hsa040680.71823060
81Sulfur metabolism_Homo sapiens_hsa009200.71511484
82Vitamin digestion and absorption_Homo sapiens_hsa049770.71420738
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71223764
84Nitrogen metabolism_Homo sapiens_hsa009100.69749550
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69165477
86VEGF signaling pathway_Homo sapiens_hsa043700.67185940
87Prolactin signaling pathway_Homo sapiens_hsa049170.67153185
88RNA polymerase_Homo sapiens_hsa030200.65783902
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65596474
90Antigen processing and presentation_Homo sapiens_hsa046120.65452468
91Mismatch repair_Homo sapiens_hsa034300.65282323
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63989414
93MAPK signaling pathway_Homo sapiens_hsa040100.61571220
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.61550688
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60923891
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.60707419
97Hepatitis B_Homo sapiens_hsa051610.60706868
98Fatty acid elongation_Homo sapiens_hsa000620.60271619
99Hepatitis C_Homo sapiens_hsa051600.59226756
100Ovarian steroidogenesis_Homo sapiens_hsa049130.59111740
101Glycerolipid metabolism_Homo sapiens_hsa005610.58839696
102Asthma_Homo sapiens_hsa053100.58641227
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57025528
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56311774
105Malaria_Homo sapiens_hsa051440.55361327
106Nucleotide excision repair_Homo sapiens_hsa034200.54834392
107T cell receptor signaling pathway_Homo sapiens_hsa046600.54547735
108Calcium signaling pathway_Homo sapiens_hsa040200.53621105
109Starch and sucrose metabolism_Homo sapiens_hsa005000.53458191
110Rheumatoid arthritis_Homo sapiens_hsa053230.51903767
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51056690
112Long-term depression_Homo sapiens_hsa047300.50843514
113Wnt signaling pathway_Homo sapiens_hsa043100.50552350
114Acute myeloid leukemia_Homo sapiens_hsa052210.49829456
115Toxoplasmosis_Homo sapiens_hsa051450.49028762
116Notch signaling pathway_Homo sapiens_hsa043300.48952937
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.48806613
118Non-small cell lung cancer_Homo sapiens_hsa052230.48185531
119Osteoclast differentiation_Homo sapiens_hsa043800.46024113
120Olfactory transduction_Homo sapiens_hsa047400.45698748
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45538517
122Lysosome_Homo sapiens_hsa041420.44963360
123TNF signaling pathway_Homo sapiens_hsa046680.44963242
124Ras signaling pathway_Homo sapiens_hsa040140.44799661
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43978553
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43954687
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43168091
128p53 signaling pathway_Homo sapiens_hsa041150.42457498
129Inositol phosphate metabolism_Homo sapiens_hsa005620.42299434
130Pyrimidine metabolism_Homo sapiens_hsa002400.42237363
131Ether lipid metabolism_Homo sapiens_hsa005650.41877636
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40980946
133HTLV-I infection_Homo sapiens_hsa051660.40573808
134B cell receptor signaling pathway_Homo sapiens_hsa046620.39973193
135Serotonergic synapse_Homo sapiens_hsa047260.39845845
136Melanoma_Homo sapiens_hsa052180.39534571
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38352584
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.37658148
139mRNA surveillance pathway_Homo sapiens_hsa030150.37602640
140Cell cycle_Homo sapiens_hsa041100.37126516

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