UXS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.86080431
2gonadal mesoderm development (GO:0007506)4.67259516
3neutrophil activation involved in immune response (GO:0002283)4.54207374
4positive regulation of male gonad development (GO:2000020)4.50810727
5pinocytosis (GO:0006907)4.33878693
6collagen fibril organization (GO:0030199)4.09219723
7positive regulation of fibroblast migration (GO:0010763)4.07303262
8negative regulation of thymocyte apoptotic process (GO:0070244)4.06235085
9chondrocyte proliferation (GO:0035988)4.03787222
10regulation of vitamin D biosynthetic process (GO:0060556)3.85002509
11regulation of male gonad development (GO:2000018)3.74668214
12signal complex assembly (GO:0007172)3.65519567
13positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.39449864
14negative regulation of hormone biosynthetic process (GO:0032353)3.37349329
15negative regulation of hormone metabolic process (GO:0032351)3.37349329
16glutamate secretion (GO:0014047)3.33696712
17protein localization to endosome (GO:0036010)3.28046486
18positive regulation of vesicle fusion (GO:0031340)3.27901787
19apoptotic cell clearance (GO:0043277)3.25291222
20positive regulation of macrophage differentiation (GO:0045651)3.24144694
21angiogenesis involved in wound healing (GO:0060055)3.24118077
22platelet degranulation (GO:0002576)3.20281469
23regulation of female gonad development (GO:2000194)3.14744884
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10359460
25ovulation cycle (GO:0042698)3.09866639
26cell adhesion mediated by integrin (GO:0033627)3.08996934
27synaptic vesicle maturation (GO:0016188)3.07472682
28thrombin receptor signaling pathway (GO:0070493)3.06561980
29protein heterotrimerization (GO:0070208)3.04967272
30cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.04812790
31cellular potassium ion homeostasis (GO:0030007)3.04262040
32peptidyl-lysine dimethylation (GO:0018027)3.03956785
33myeloid dendritic cell differentiation (GO:0043011)3.02670986
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.01493608
35axon extension involved in axon guidance (GO:0048846)3.01493608
36negative regulation of fatty acid transport (GO:2000192)3.00480803
37regulation of vitamin metabolic process (GO:0030656)2.99644929
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99236697
39platelet aggregation (GO:0070527)2.99089145
40protein maturation by protein folding (GO:0022417)2.98513593
41positive regulation of gamma-delta T cell activation (GO:0046645)2.93295281
42synaptic vesicle exocytosis (GO:0016079)2.91605175
43positive regulation of synapse maturation (GO:0090129)2.91603178
44nuclear pore organization (GO:0006999)2.90190231
45collagen catabolic process (GO:0030574)2.90071765
46membrane raft organization (GO:0031579)2.89913623
47nuclear pore complex assembly (GO:0051292)2.89774053
48regulation of translational termination (GO:0006449)2.88904347
49positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88712880
50myeloid dendritic cell activation (GO:0001773)2.88058793
51leukocyte aggregation (GO:0070486)2.87543624
52Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86945847
53regulation of regulatory T cell differentiation (GO:0045589)2.86935830
54hyaluronan catabolic process (GO:0030214)2.84192511
55cellular response to interferon-alpha (GO:0035457)2.83421539
56positive regulation of macrophage cytokine production (GO:0060907)2.83282779
57regulation of integrin activation (GO:0033623)2.82680935
58collagen metabolic process (GO:0032963)2.82162107
59regulation of interleukin-2 biosynthetic process (GO:0045076)2.81958427
60piRNA metabolic process (GO:0034587)2.81136499
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80764629
62blood coagulation, intrinsic pathway (GO:0007597)2.79372680
63negative regulation of nitric oxide biosynthetic process (GO:0045019)2.78422115
64keratan sulfate catabolic process (GO:0042340)2.78356459
65positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78129224
66regulation of podosome assembly (GO:0071801)2.76712318
67NLS-bearing protein import into nucleus (GO:0006607)2.76661978
68positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.76442481
69stress fiber assembly (GO:0043149)2.75069401
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.73955894
71positive regulation of endothelial cell apoptotic process (GO:2000353)2.73002647
72regulation of platelet aggregation (GO:0090330)2.70271476
73endodermal cell differentiation (GO:0035987)2.69952217
74regulation of synaptic vesicle exocytosis (GO:2000300)2.69609228
75granulocyte activation (GO:0036230)2.69539728
76pentose-phosphate shunt (GO:0006098)2.69009018
77regulation of immunoglobulin secretion (GO:0051023)2.67976233
78mating behavior (GO:0007617)2.67773118
79regulation of platelet activation (GO:0010543)2.67461617
80fibrinolysis (GO:0042730)2.66516714
81positive regulation of blood coagulation (GO:0030194)2.65697287
82positive regulation of hemostasis (GO:1900048)2.65697287
83low-density lipoprotein particle remodeling (GO:0034374)2.64919734
84regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63831388
85regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62917492
86negative regulation of cell killing (GO:0031342)2.61989407
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61989407
88modulation by symbiont of host cellular process (GO:0044068)2.61283144
89multicellular organismal macromolecule metabolic process (GO:0044259)2.61226410
90positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.60701299
91response to peptidoglycan (GO:0032494)2.59585375
92negative regulation of T cell apoptotic process (GO:0070233)2.58311750
93negative regulation of interleukin-17 production (GO:0032700)2.58050184
94protein retention in ER lumen (GO:0006621)2.57446936
95Golgi transport vesicle coating (GO:0048200)2.56772978
96COPI coating of Golgi vesicle (GO:0048205)2.56772978
97regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56440220
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56216827
99mesodermal cell differentiation (GO:0048333)2.55889231
100neutrophil activation (GO:0042119)2.54420126
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.53844866
102multicellular organismal catabolic process (GO:0044243)2.53733409
103positive regulation of axon extension (GO:0045773)2.53560874
104cyclooxygenase pathway (GO:0019371)2.53435869
105lipoxygenase pathway (GO:0019372)2.53053785
106regulation of T-helper 1 cell differentiation (GO:0045625)2.52705903
107positive regulation of extracellular matrix organization (GO:1903055)2.52070593
108negative regulation of interleukin-12 production (GO:0032695)2.51500894
109regulation of macrophage chemotaxis (GO:0010758)2.51317188
110positive regulation of coagulation (GO:0050820)2.50290793
111negative regulation of homotypic cell-cell adhesion (GO:0034111)2.49703319
112positive regulation of tolerance induction (GO:0002645)2.49645787
113sequestering of extracellular ligand from receptor (GO:0035581)2.49344221
114platelet activation (GO:0030168)2.48871162
115peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.47344493
116regulation of T cell tolerance induction (GO:0002664)2.46762465
117multicellular organismal metabolic process (GO:0044236)2.46645312
118regulation of macrophage cytokine production (GO:0010935)2.44891522
119cytoskeleton-dependent cytokinesis (GO:0061640)2.44790374
120peptide catabolic process (GO:0043171)2.44665831
121plasma membrane repair (GO:0001778)2.44244033
122chondroitin sulfate biosynthetic process (GO:0030206)2.43714178
123leukocyte degranulation (GO:0043299)2.43657583
124lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43657076
125regulation of synaptic vesicle transport (GO:1902803)2.43364174
126NADPH regeneration (GO:0006740)2.42903733
127glucocorticoid receptor signaling pathway (GO:0042921)2.42651065
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.42611497
129mature B cell differentiation involved in immune response (GO:0002313)2.42117727
130negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.42041882
131homotypic cell-cell adhesion (GO:0034109)2.41635185
132negative regulation of platelet activation (GO:0010544)2.41540278
133meiotic chromosome segregation (GO:0045132)2.41059539
134response to magnesium ion (GO:0032026)2.40178434
135cellular response to thyroid hormone stimulus (GO:0097067)2.39419029
136regulation of clathrin-mediated endocytosis (GO:2000369)2.38870735
137cytokine production involved in immune response (GO:0002367)2.38642007
138NIK/NF-kappaB signaling (GO:0038061)2.38458251
139regulation of early endosome to late endosome transport (GO:2000641)2.38246076
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.38082842
141negative regulation of meiosis (GO:0045835)2.37587466
142embryonic viscerocranium morphogenesis (GO:0048703)2.37201855
143fat-soluble vitamin catabolic process (GO:0042363)2.37179191
144vitamin catabolic process (GO:0009111)2.37179191
145locomotory exploration behavior (GO:0035641)2.36639862
146decidualization (GO:0046697)2.35981832
147extracellular matrix disassembly (GO:0022617)2.35641644
148sodium ion export (GO:0071436)2.34919796
149regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34777547
150heterochromatin organization (GO:0070828)2.34706956
151hypotonic response (GO:0006971)2.34549532
152negative regulation of monooxygenase activity (GO:0032769)2.34086128
153regulation of chronic inflammatory response (GO:0002676)2.32274803
154dermatan sulfate biosynthetic process (GO:0030208)2.32103344
155regulation of superoxide anion generation (GO:0032928)2.30812151
156positive regulation of nitric-oxide synthase activity (GO:0051000)2.28638286
157phagocytosis, engulfment (GO:0006911)2.28501068
158regulation of mitotic spindle organization (GO:0060236)2.27770877
159regulation of interleukin-17 production (GO:0032660)2.27020723
160germ cell migration (GO:0008354)2.26986285
161regulation of tight junction assembly (GO:2000810)2.26461555
162iron ion import (GO:0097286)2.26072905
163positive regulation of dendrite morphogenesis (GO:0050775)2.25467926
164growth hormone receptor signaling pathway (GO:0060396)2.25431079
165protein localization to cilium (GO:0061512)2.25118061
166negative regulation of myeloid cell apoptotic process (GO:0033033)2.24552293
167regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24296317
168skin morphogenesis (GO:0043589)2.24156840
169substrate-dependent cell migration (GO:0006929)2.24002886
170leukocyte cell-cell adhesion (GO:0007159)2.23344658
171positive regulation of isotype switching (GO:0045830)2.22489985
172adenosine receptor signaling pathway (GO:0001973)2.22339343
173phosphorelay signal transduction system (GO:0000160)2.22150681
174regulation of meiosis I (GO:0060631)2.22113303
175barbed-end actin filament capping (GO:0051016)2.22054967
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.21629756
177regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21541486
178regulation of RIG-I signaling pathway (GO:0039535)2.20086573
179regulation of integrin-mediated signaling pathway (GO:2001044)2.19482366
180regulation of long-term neuronal synaptic plasticity (GO:0048169)2.19189855
181T cell migration (GO:0072678)2.18029129
182regulation of glutamate receptor signaling pathway (GO:1900449)2.17861866
183regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.17851165
184regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.17851165
185modulation by virus of host process (GO:0019054)2.17532205
186peptidyl-proline hydroxylation (GO:0019511)2.16941310
187regulation of metalloenzyme activity (GO:0048552)2.16814029
188positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.16629606
189negative regulation of protein localization to plasma membrane (GO:1903077)2.16315445
190cellular response to ATP (GO:0071318)2.16007158
191regulation of synapse structural plasticity (GO:0051823)2.15835411
192endothelium development (GO:0003158)2.15771502
193regulation of T-helper 2 cell differentiation (GO:0045628)2.14659036
194embryonic process involved in female pregnancy (GO:0060136)2.14264628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.13636055
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.89963928
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.53289061
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23237624
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.18928392
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67436590
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57063590
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.54117635
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53648216
10EZH2_22144423_ChIP-Seq_EOC_Human2.49496830
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.46926259
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.40157956
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37029501
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35044167
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.33321290
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30130398
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20355201
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19729171
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19047048
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.18943529
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13294510
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08222605
23ESR1_15608294_ChIP-ChIP_MCF-7_Human2.08011097
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07839001
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02655949
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01862317
27* IRF8_27001747_Chip-Seq_BMDM_Mouse2.00905375
28IRF8_22096565_ChIP-ChIP_GC-B_Human2.00512231
29* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.94867747
30* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91430434
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.88664635
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.85774151
33E2F7_22180533_ChIP-Seq_HELA_Human1.85358590
34GBX2_23144817_ChIP-Seq_PC3_Human1.79487841
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78787804
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72807765
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.71846854
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71626838
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71371173
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68285321
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.68203990
42AR_21572438_ChIP-Seq_LNCaP_Human1.67699947
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.66905585
44MYC_22102868_ChIP-Seq_BL_Human1.64763599
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64361721
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63674231
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63640500
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62309485
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61894846
50SPI1_23547873_ChIP-Seq_NB4_Human1.60866999
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60355184
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60355184
53TP53_18474530_ChIP-ChIP_U2OS_Human1.59605288
54BRD4_25478319_ChIP-Seq_HGPS_Human1.58584630
55* MYB_26560356_Chip-Seq_TH2_Human1.57500449
56CLOCK_20551151_ChIP-Seq_293T_Human1.57223657
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57195415
58SCL_19346495_ChIP-Seq_HPC-7_Human1.56437879
59CJUN_26792858_Chip-Seq_BT549_Human1.56019992
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55718319
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.53929157
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52379512
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52191713
64SPI1_23127762_ChIP-Seq_K562_Human1.51733227
65AR_21909140_ChIP-Seq_LNCAP_Human1.50783157
66RUNX_20019798_ChIP-Seq_JUKART_Human1.49288110
67TP53_16413492_ChIP-PET_HCT116_Human1.48900828
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47405652
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46774092
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45649124
71UTX_26944678_Chip-Seq_JUKART_Human1.44693021
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43994677
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43081998
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42748457
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42700648
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42364067
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42237051
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42155461
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40064164
80VDR_24763502_ChIP-Seq_THP-1_Human1.40039689
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39469731
82VDR_21846776_ChIP-Seq_THP-1_Human1.39158608
83MAF_26560356_Chip-Seq_TH1_Human1.38570881
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38118965
85* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37061241
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36302005
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36119022
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33022778
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.31488021
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30687014
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30687014
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29904609
93KDM2B_26808549_Chip-Seq_K562_Human1.29588142
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.28699755
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28526121
96* ATF3_27146783_Chip-Seq_COLON_Human1.27517000
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24417527
98TCF7_22412390_ChIP-Seq_EML_Mouse1.24310864
99* PU_27001747_Chip-Seq_BMDM_Mouse1.24186994
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23514771
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20733210
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20714643
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20693686
104* MYB_26560356_Chip-Seq_TH1_Human1.20428137
105SMAD4_21799915_ChIP-Seq_A2780_Human1.18580521
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18115311
107IGF1R_20145208_ChIP-Seq_DFB_Human1.17410898
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17076956
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16201990
110* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16164379
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15751170
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15088469
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14841496
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14765697
115RXR_22108803_ChIP-Seq_LS180_Human1.14429948
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12234217
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12004795
118NCOR1_26117541_ChIP-Seq_K562_Human1.11778657
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11575340
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11101884
121SALL1_21062744_ChIP-ChIP_HESCs_Human1.10344656
122TFEB_21752829_ChIP-Seq_HELA_Human1.09330552
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09157194
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08799440
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08742330
126JUN_21703547_ChIP-Seq_K562_Human1.07898276
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07892490
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05323381
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05217333
130* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05096213
131MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04364299
132GATA3_27048872_Chip-Seq_THYMUS_Human1.03871600
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03860392
134ESR1_21235772_ChIP-Seq_MCF-7_Human1.03849424
135ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03592193
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02912331
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01971922
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01762583
139* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01525890
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01198931
141* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01041591
142HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00350680
143DROSHA_22980978_ChIP-Seq_HELA_Human1.00151582
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00071290
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99477823
146JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99169678
147STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99053518
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99050536
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98772597
150BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98411464
151SOX2_21211035_ChIP-Seq_LN229_Gbm0.98102844
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97887303
153ZNF263_19887448_ChIP-Seq_K562_Human0.97045657
154STAT3_23295773_ChIP-Seq_U87_Human0.96920276
155SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96791727
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96791727
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96705653
158KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96643776
159PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96461009
160MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96136155
161PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95245619
162* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95061758
163TP53_23651856_ChIP-Seq_MEFs_Mouse0.94020485
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93662492
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.92419298
166* SMAD4_21741376_ChIP-Seq_EPCs_Human0.92364698
167BCAT_22108803_ChIP-Seq_LS180_Human0.91866819
168UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91518809
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.91369564
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89218401
171YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88947421
172SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88868044
173SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88675987
174* TCF4_22108803_ChIP-Seq_LS180_Human0.87826442
175FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87354683
176NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87039159
177ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86058607
178KDM2B_26808549_Chip-Seq_DND41_Human0.86015978
179ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85946705
180UBF1/2_26484160_Chip-Seq_HMECs_Human0.85420046
181VDR_24787735_ChIP-Seq_THP-1_Human0.84689461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.61642725
2MP0005464_abnormal_platelet_physiology4.18367559
3MP0004859_abnormal_synaptic_plasticity3.96520045
4MP0005623_abnormal_meninges_morphology3.83339727
5MP0003705_abnormal_hypodermis_morpholog3.48577215
6MP0005503_abnormal_tendon_morphology3.17010984
7MP0003436_decreased_susceptibility_to3.11840482
8MP0001958_emphysema2.72258670
9MP0003724_increased_susceptibility_to2.47279180
10MP0002148_abnormal_hypersensitivity_rea2.42963041
11MP0005451_abnormal_body_composition2.42324409
12MP0005275_abnormal_skin_tensile2.41458912
13MP0009384_cardiac_valve_regurgitation2.31555407
14MP0003091_abnormal_cell_migration2.26602813
15MP0009780_abnormal_chondrocyte_physiolo2.24200181
16MP0009785_altered_susceptibility_to2.22593992
17MP0003566_abnormal_cell_adhesion2.19427336
18MP0005076_abnormal_cell_differentiation2.19276335
19MP0009840_abnormal_foam_cell2.14992858
20MP0010352_gastrointestinal_tract_polyps2.11049973
21MP0002877_abnormal_melanocyte_morpholog2.05360345
22MP0008877_abnormal_DNA_methylation1.99428489
23MP0005000_abnormal_immune_tolerance1.97033879
24MP0004947_skin_inflammation1.93952831
25MP0002896_abnormal_bone_mineralization1.86167457
26MP0003279_aneurysm1.86010928
27MP0008260_abnormal_autophagy1.85308949
28MP0002419_abnormal_innate_immunity1.83016874
29MP0001835_abnormal_antigen_presentation1.80983079
30MP0010307_abnormal_tumor_latency1.77313155
31MP0000465_gastrointestinal_hemorrhage1.77102690
32MP0001348_abnormal_lacrimal_gland1.72445006
33MP0006082_CNS_inflammation1.71513115
34MP0005671_abnormal_response_to1.71285990
35MP0010155_abnormal_intestine_physiology1.69479059
36MP0004272_abnormal_basement_membrane1.68243775
37MP0002282_abnormal_trachea_morphology1.68059076
38MP0003879_abnormal_hair_cell1.67093594
39MP0005025_abnormal_response_to1.66458229
40MP0003172_abnormal_lysosome_physiology1.66125639
41MP0003950_abnormal_plasma_membrane1.66055192
42MP0003045_fibrosis1.65328283
43MP0002089_abnormal_postnatal_growth/wei1.64049424
44MP0000569_abnormal_digit_pigmentation1.63849564
45MP0003828_pulmonary_edema1.61941630
46MP0001853_heart_inflammation1.59192428
47MP0003300_gastrointestinal_ulcer1.58839121
48MP0002115_abnormal_skeleton_extremities1.55883698
49MP0003635_abnormal_synaptic_transmissio1.53925676
50MP0005387_immune_system_phenotype1.53393882
51MP0001790_abnormal_immune_system1.53393882
52MP0000343_altered_response_to1.53058921
53MP0002452_abnormal_antigen_presenting1.52028408
54MP0002723_abnormal_immune_serum1.49587196
55MP0009333_abnormal_splenocyte_physiolog1.49230169
56MP0003191_abnormal_cellular_cholesterol1.46840931
57MP0003763_abnormal_thymus_physiology1.45530233
58MP0001915_intracranial_hemorrhage1.45403429
59MP0001542_abnormal_bone_strength1.44270300
60MP0004858_abnormal_nervous_system1.43696576
61MP0002063_abnormal_learning/memory/cond1.42064451
62MP0001849_ear_inflammation1.40583152
63MP0005508_abnormal_skeleton_morphology1.40015124
64MP0000163_abnormal_cartilage_morphology1.39958485
65MP0003453_abnormal_keratinocyte_physiol1.38180962
66MP0005171_absent_coat_pigmentation1.37607587
67MP0002420_abnormal_adaptive_immunity1.37551204
68MP0001819_abnormal_immune_cell1.37058297
69MP0002405_respiratory_system_inflammati1.36760834
70MP0009278_abnormal_bone_marrow1.33877557
71MP0002113_abnormal_skeleton_development1.33281975
72MP0001800_abnormal_humoral_immune1.32868243
73MP0009764_decreased_sensitivity_to1.32772424
74MP0001299_abnormal_eye_distance/1.31457861
75MP0001984_abnormal_olfaction1.30813521
76MP0003656_abnormal_erythrocyte_physiolo1.29915328
77MP0005165_increased_susceptibility_to1.25563566
78MP0002398_abnormal_bone_marrow1.25243681
79MP0002736_abnormal_nociception_after1.24207737
80MP0008995_early_reproductive_senescence1.23021220
81MP0001845_abnormal_inflammatory_respons1.22036021
82MP0006054_spinal_hemorrhage1.20255001
83MP0000751_myopathy1.19146402
84MP0005167_abnormal_blood-brain_barrier1.18542899
85MP0010368_abnormal_lymphatic_system1.17186311
86MP0002160_abnormal_reproductive_system1.17159622
87MP0000534_abnormal_ureter_morphology1.17104728
88MP0005164_abnormal_response_to1.14293886
89MP0002722_abnormal_immune_system1.14165306
90MP0003806_abnormal_nucleotide_metabolis1.13985525
91MP0009250_abnormal_appendicular_skeleto1.11888162
92MP0009763_increased_sensitivity_to1.11787956
93MP0000716_abnormal_immune_system1.10807218
94MP0002429_abnormal_blood_cell1.08877832
95MP0000689_abnormal_spleen_morphology1.08836820
96MP0003123_paternal_imprinting1.08776595
97MP0000490_abnormal_crypts_of1.08614925
98MP0001968_abnormal_touch/_nociception1.08418947
99MP0002998_abnormal_bone_remodeling1.07932822
100MP0000685_abnormal_immune_system1.07749703
101MP0003880_abnormal_central_pattern1.07453405
102MP0002909_abnormal_adrenal_gland1.06572049
103MP0005023_abnormal_wound_healing1.06311640
104MP0009697_abnormal_copulation1.06164153
105MP0002735_abnormal_chemical_nociception1.05371540
106MP0002295_abnormal_pulmonary_circulatio1.04908705
107MP0000604_amyloidosis1.03998507
108MP0002933_joint_inflammation1.03268196
109MP0003795_abnormal_bone_structure1.02748889
110MP0004808_abnormal_hematopoietic_stem1.02047392
111MP0002168_other_aberrant_phenotype1.00324847
112MP0008469_abnormal_protein_level1.00202803
113MP0005377_hearing/vestibular/ear_phenot1.00068318
114MP0003878_abnormal_ear_physiology1.00068318
115MP0005390_skeleton_phenotype0.99984398
116MP0000249_abnormal_blood_vessel0.98248612
117MP0009745_abnormal_behavioral_response0.96124744
118MP0000428_abnormal_craniofacial_morphol0.95048808
119MP0003075_altered_response_to0.93895795
120MP0001533_abnormal_skeleton_physiology0.92162081
121MP0002928_abnormal_bile_duct0.91489761
122MP0004811_abnormal_neuron_physiology0.89524461
123MP0005621_abnormal_cell_physiology0.89271159
124MP0004134_abnormal_chest_morphology0.88352375
125MP0000858_altered_metastatic_potential0.88062859
126MP0005257_abnormal_intraocular_pressure0.87242714
127MP0009765_abnormal_xenobiotic_induced0.86504260
128MP0001119_abnormal_female_reproductive0.85210613
129MP0000703_abnormal_thymus_morphology0.85172788
130MP0004233_abnormal_muscle_weight0.83663023
131MP0005310_abnormal_salivary_gland0.83502589
132MP0003942_abnormal_urinary_system0.83372204
133MP0002109_abnormal_limb_morphology0.83322567
134MP0008004_abnormal_stomach_pH0.82781219
135MP0000733_abnormal_muscle_development0.82537312
136MP0003303_peritoneal_inflammation0.81769004
137MP0002132_abnormal_respiratory_system0.79828818
138MP0001177_atelectasis0.78989524
139MP0001919_abnormal_reproductive_system0.78895843
140MP0001216_abnormal_epidermal_layer0.78894598
141MP0005166_decreased_susceptibility_to0.77287359
142MP0005389_reproductive_system_phenotype0.76282792
143MP0005501_abnormal_skin_physiology0.76093724
144MP0004883_abnormal_blood_vessel0.76075077
145MP0004084_abnormal_cardiac_muscle0.76072616
146MP0003448_altered_tumor_morphology0.75651194
147MP0002572_abnormal_emotion/affect_behav0.75549805
148MP0001730_embryonic_growth_arrest0.74600155
149MP0008007_abnormal_cellular_replicative0.74553336
150MP0001873_stomach_inflammation0.74520900
151MP0002064_seizures0.71618899
152MP0010234_abnormal_vibrissa_follicle0.70900296
153MP0001851_eye_inflammation0.70428858
154MP0001765_abnormal_ion_homeostasis0.69923200
155MP0005058_abnormal_lysosome_morphology0.69013568
156MP0003283_abnormal_digestive_organ0.68913759
157MP0004510_myositis0.64934012
158MP0004185_abnormal_adipocyte_glucose0.63178518
159MP0003115_abnormal_respiratory_system0.62021732
160MP0002060_abnormal_skin_morphology0.61309597
161MP0003111_abnormal_nucleus_morphology0.61305938
162MP0002184_abnormal_innervation0.59908034
163MP0003786_premature_aging0.59802038
164MP0002932_abnormal_joint_morphology0.59651216
165MP0002108_abnormal_muscle_morphology0.59496796
166MP0005397_hematopoietic_system_phenotyp0.59413210
167MP0001545_abnormal_hematopoietic_system0.59413210

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)5.53603906
2Increased mean platelet volume (HP:0011877)5.25150875
3Prolonged bleeding time (HP:0003010)5.07267364
4Abnormal platelet volume (HP:0011876)4.98192408
5Protrusio acetabuli (HP:0003179)4.95415684
6Purpura (HP:0000979)4.94233627
7Premature rupture of membranes (HP:0001788)4.39439857
8Petechiae (HP:0000967)4.33799403
9Epistaxis (HP:0000421)4.11180418
10Epiphyseal dysplasia (HP:0002656)3.91649995
11Ankle contracture (HP:0006466)3.80157826
12Gingival bleeding (HP:0000225)3.68256713
13Cervical subluxation (HP:0003308)3.49338687
14Absent frontal sinuses (HP:0002688)3.47957512
15Abnormal platelet function (HP:0011869)3.35005100
16Impaired platelet aggregation (HP:0003540)3.35005100
17Shallow orbits (HP:0000586)3.24294021
18Metaphyseal cupping (HP:0003021)3.22702326
19Neonatal short-limb short stature (HP:0008921)3.21003564
20Aortic dissection (HP:0002647)3.13414166
21Abnormality of macrophages (HP:0004311)3.05092438
22T lymphocytopenia (HP:0005403)3.02534304
23Cerebral aneurysm (HP:0004944)3.01057585
24Autoimmune hemolytic anemia (HP:0001890)2.97996611
25Stomatitis (HP:0010280)2.97124266
26Dysostosis multiplex (HP:0000943)2.96222163
27Abnormality of dentin (HP:0010299)2.95289564
28Hand muscle atrophy (HP:0009130)2.94618760
29Upper limb amyotrophy (HP:0009129)2.93875786
30Distal upper limb amyotrophy (HP:0007149)2.93875786
31Loss of speech (HP:0002371)2.88124508
32Increased cerebral lipofuscin (HP:0011813)2.87854989
33Abnormality of the common coagulation pathway (HP:0010990)2.87679352
34Cupped ribs (HP:0000887)2.86169024
35Deep venous thrombosis (HP:0002625)2.83948824
36Genu recurvatum (HP:0002816)2.79821982
37Abnormality of liposaccharide metabolism (HP:0010968)2.78714253
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.78714253
39Abnormality of glycolipid metabolism (HP:0010969)2.78714253
40Radial bowing (HP:0002986)2.77082455
41Myocardial infarction (HP:0001658)2.73638490
42Vacuolated lymphocytes (HP:0001922)2.67692489
43Thin bony cortex (HP:0002753)2.66712478
44Irregular epiphyses (HP:0010582)2.63867059
45Mesomelia (HP:0003027)2.63615425
46Mild short stature (HP:0003502)2.63363787
47Eczematoid dermatitis (HP:0000976)2.61423112
48Dilatation of the ascending aorta (HP:0005111)2.58508334
49Soft skin (HP:0000977)2.58290493
50Coxa vara (HP:0002812)2.57255181
51Delayed epiphyseal ossification (HP:0002663)2.57086081
52Abnormality of T cell number (HP:0011839)2.56962525
53Arterial tortuosity (HP:0005116)2.54693612
54Increased IgM level (HP:0003496)2.52738704
55Hypoplasia of the odontoid process (HP:0003311)2.52149890
56Follicular hyperkeratosis (HP:0007502)2.51624620
57Vascular tortuosity (HP:0004948)2.51133691
58Spinal cord compression (HP:0002176)2.49521761
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.47467300
60Hypoplastic ischia (HP:0003175)2.46446714
61Spondylolisthesis (HP:0003302)2.44181968
62Slender build (HP:0001533)2.42033355
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.41431691
64Wrist flexion contracture (HP:0001239)2.41009644
65Bladder diverticulum (HP:0000015)2.39990056
66Aortic aneurysm (HP:0004942)2.39927164
67Peritonitis (HP:0002586)2.39789957
68Increased serum ferritin (HP:0003281)2.36757710
69Wormian bones (HP:0002645)2.36655770
70Flat acetabular roof (HP:0003180)2.36524952
71Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34464036
72Abnormality of the odontoid process (HP:0003310)2.34285445
73Hepatosplenomegaly (HP:0001433)2.33196516
74Combined immunodeficiency (HP:0005387)2.26091823
75Interstitial pulmonary disease (HP:0006530)2.24801917
76Thrombocytosis (HP:0001894)2.24367557
77Mitral valve prolapse (HP:0001634)2.22055254
78Recurrent gram-negative bacterial infections (HP:0005420)2.20283861
79Tibial bowing (HP:0002982)2.19130938
80Abnormality of the acetabulum (HP:0003170)2.18947171
81Joint hemorrhage (HP:0005261)2.17901830
82Abnormality of the calcaneus (HP:0008364)2.17880237
83Enlarged epiphyses (HP:0010580)2.17544068
84Abnormality of the ischium (HP:0003174)2.17143108
85Platyspondyly (HP:0000926)2.16133275
86Osteoarthritis (HP:0002758)2.14933804
87Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.14492141
88Abnormality of the proximal phalanges of the hand (HP:0009834)2.13931642
89Atrophic scars (HP:0001075)2.13278259
90Recurrent abscess formation (HP:0002722)2.12534140
91Focal motor seizures (HP:0011153)2.12216473
92Systemic lupus erythematosus (HP:0002725)2.12188642
93Conjunctival telangiectasia (HP:0000524)2.12002499
94Flat capital femoral epiphysis (HP:0003370)2.11536283
95Distal lower limb amyotrophy (HP:0008944)2.11517936
96Ulnar bowing (HP:0003031)2.09228973
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07939727
98Vitreoretinal degeneration (HP:0000655)2.06523846
99Urinary glycosaminoglycan excretion (HP:0003541)2.05339842
100Mucopolysacchariduria (HP:0008155)2.05339842
101Limb-girdle muscle atrophy (HP:0003797)2.02971920
102Severe combined immunodeficiency (HP:0004430)2.01068743
103Abnormality of the frontal sinuses (HP:0002687)2.00913911
104Vertebral compression fractures (HP:0002953)2.00687485
105Disinhibition (HP:0000734)1.99104531
106Enlarged penis (HP:0000040)1.98566143
107Blue sclerae (HP:0000592)1.95520273
108Autoimmune thrombocytopenia (HP:0001973)1.94850151
109Abnormality of the Achilles tendon (HP:0005109)1.94824633
110Bruising susceptibility (HP:0000978)1.93505838
111Increased density of long bones (HP:0006392)1.92263596
112Obstructive lung disease (HP:0006536)1.92183271
113Chronic obstructive pulmonary disease (HP:0006510)1.92183271
114Joint swelling (HP:0001386)1.92023307
115Elevated erythrocyte sedimentation rate (HP:0003565)1.92006610
116Diminished motivation (HP:0000745)1.91834232
117Apathy (HP:0000741)1.91767649
118Back pain (HP:0003418)1.91734307
119Rough bone trabeculation (HP:0100670)1.90678604
120Femoral bowing (HP:0002980)1.89719655
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89468300
122Abnormality of polysaccharide metabolism (HP:0011012)1.89468300
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89468300
124Abnormality of iron homeostasis (HP:0011031)1.89109343
125Elbow flexion contracture (HP:0002987)1.87966260
126B lymphocytopenia (HP:0010976)1.87864162
127Myositis (HP:0100614)1.86791978
128Leukocytosis (HP:0001974)1.86195666
129Beaking of vertebral bodies (HP:0004568)1.85614222
130Abnormal foot bone ossification (HP:0010675)1.85611833
131Bowel diverticulosis (HP:0005222)1.85264384
132Mediastinal lymphadenopathy (HP:0100721)1.84383575
133Broad long bones (HP:0005622)1.82467425
134Small epiphyses (HP:0010585)1.82323732
135Hyperextensible skin (HP:0000974)1.81776310
136Bowing of the arm (HP:0006488)1.81457906
137Bowed forearm bones (HP:0003956)1.81457906
138Striae distensae (HP:0001065)1.81263123
139Abnormal tarsal ossification (HP:0008369)1.80508695
140Short nail (HP:0001799)1.80354292
141Pustule (HP:0200039)1.79884283
142Recurrent bacterial skin infections (HP:0005406)1.78850707
143Granulocytopenia (HP:0001913)1.78381638
144IgA deficiency (HP:0002720)1.78375404
145Thin ribs (HP:0000883)1.78026815
146Biconcave vertebral bodies (HP:0004586)1.77826221
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77825106
148Xanthomatosis (HP:0000991)1.77782411
149Subacute progressive viral hepatitis (HP:0006572)1.76494005
150Hyperlipoproteinemia (HP:0010980)1.75682023
151Male infertility (HP:0003251)1.75517272
152Abnormality of the lumbar spine (HP:0100712)1.75438783
153Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.75312840
154Arterial thrombosis (HP:0004420)1.75205664
155Lower limb amyotrophy (HP:0007210)1.74718087
156Aplasia involving bones of the upper limbs (HP:0009823)1.73914193
157Aplasia of the phalanges of the hand (HP:0009802)1.73914193
158Aplasia involving bones of the extremities (HP:0009825)1.73914193
159Distal lower limb muscle weakness (HP:0009053)1.72478656
160Eosinophilia (HP:0001880)1.72349723
161Stillbirth (HP:0003826)1.70334699
162Orchitis (HP:0100796)1.69727772
163Joint laxity (HP:0001388)1.69619564
164Ovoid vertebral bodies (HP:0003300)1.69139361
165Upper motor neuron abnormality (HP:0002127)1.68525859
166Flattened epiphyses (HP:0003071)1.67753396
167Fragile skin (HP:0001030)1.67344328
168Abnormality of the lower motor neuron (HP:0002366)1.67198744
169Hypoventilation (HP:0002791)1.66281779
170Joint stiffness (HP:0001387)1.65623088
171Osteopenia (HP:0000938)1.65200643
172Osteolytic defects of the hand bones (HP:0009699)1.63597703
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.63597703
174Pelvic girdle muscle weakness (HP:0003749)1.63310968
175Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62255281
176Recurrent fungal infections (HP:0002841)1.61561869
177Neurofibrillary tangles (HP:0002185)1.60815884
178Cerebral inclusion bodies (HP:0100314)1.60618349
179Thick nail (HP:0001805)1.59963543
180Glomerulopathy (HP:0100820)1.59436878
181Thrombophlebitis (HP:0004418)1.58936387
182Achilles tendon contracture (HP:0001771)1.58884094
183Amyloidosis (HP:0011034)1.57975391
184Hypergammaglobulinemia (HP:0010702)1.57917488
185Recurrent viral infections (HP:0004429)1.57170398
186Selective tooth agenesis (HP:0001592)1.55835488
187Spontaneous hematomas (HP:0007420)1.55623904
188Nuclear cataract (HP:0100018)1.55466626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.83986595
2DDR23.58188151
3IRAK33.36120330
4NME23.05753915
5EPHA42.91296725
6PLK22.60831603
7NTRK32.58750957
8MAP3K92.53366565
9CAMKK22.52704046
10PKN22.35192116
11CAMKK12.33274448
12SCYL22.24244543
13SIK32.18330854
14KSR22.14597999
15ZAP702.12926880
16TESK12.07628387
17DAPK22.02585888
18PTK2B1.99666340
19FGR1.99279651
20TGFBR21.90750730
21CSF1R1.87251203
22PIM21.85568416
23TAOK21.83479869
24MAP2K31.82529752
25LATS21.78484797
26MAP3K141.76231888
27MAP3K31.75990512
28RIPK41.71942239
29TXK1.70784905
30CDK121.66922718
31PAK61.62823857
32PAK41.59893248
33CSK1.59546144
34MOS1.53430452
35PDGFRA1.52838478
36ERN11.51079141
37MYLK1.50496566
38LIMK11.50276680
39DAPK11.50086726
40FGFR41.46905557
41MST41.39482979
42BMX1.38733825
43MAP3K21.37881654
44LATS11.34321699
45TEC1.33919083
46RAF11.33499563
47TYK21.32537369
48TRPM71.30603515
49NEK11.29105404
50MAP3K41.29071091
51ALK1.28926913
52MATK1.27761903
53TBK11.27228632
54BTK1.25947767
55JAK31.24535564
56TTN1.23767087
57MAP3K131.20816763
58PRKD31.19319267
59MAP3K121.17762695
60NEK91.16402328
61MAP4K11.14380526
62KSR11.14099519
63MAP3K51.10704871
64CCNB11.10133451
65TYRO31.09847056
66ARAF1.08228875
67STK101.08139092
68EPHA31.07832225
69RET1.07815858
70CDC71.06616659
71KDR1.06525571
72PRPF4B1.05615565
73FER1.05592516
74TAOK11.05198848
75MET1.00920490
76STK380.99612114
77RPS6KA40.98637082
78RIPK10.97574420
79MINK10.96509396
80TTK0.96388221
81SIK10.96291808
82SYK0.95017097
83EPHB10.91196695
84STK30.91138393
85BLK0.89855047
86CDK60.88921033
87EEF2K0.87724029
88MARK30.86708044
89STK38L0.84696973
90MAP2K10.83468975
91EIF2AK30.83020344
92IKBKB0.82963929
93LRRK20.81311017
94NTRK10.80173228
95EPHA20.78695194
96PTK20.76851541
97LCK0.75343523
98MST1R0.75341090
99GRK70.73359352
100GRK50.73276893
101SIK20.72192836
102CDK80.71540563
103CDK90.71448432
104PBK0.70683024
105CASK0.69907324
106SMG10.69684764
107TIE10.68662944
108GRK60.68439946
109PIK3CG0.67085140
110PTK60.66968327
111ERBB30.66616880
112EIF2AK10.66552411
113CLK10.64520828
114MAP3K10.64411597
115CDC42BPA0.64039820
116PLK30.63571542
117STK240.63185028
118LYN0.62992419
119MAP2K70.59419469
120ILK0.59105181
121SRPK10.58294693
122ERBB40.58034816
123FGFR10.57224090
124ACVR1B0.56903336
125ITK0.55486717
126PAK30.54769169
127CDK40.54538618
128PAK20.53790871
129NEK20.52109721
130SGK30.50774425
131CDK140.48118914
132PDPK10.47891535
133FLT30.47035919
134PIM10.45734657
135SGK10.44574059
136JAK10.44227664
137MAP3K60.43785949
138NUAK10.43282201
139BRAF0.42959422
140CDK180.42470501
141PDK10.41556413
142MAPKAPK20.40480414
143MAP2K40.40222796
144CDK150.40062862
145ABL20.38823264
146PDGFRB0.38703732
147FES0.38564623
148SGK20.38333162
149BMPR20.37743048
150CDK50.37603962
151CAMK1D0.37037624
152DMPK0.36033347
153MAP3K80.35797088
154ICK0.35594533
155CDK70.35189383
156TESK20.34598221
157FYN0.34553456
158MAPK110.34316860
159EGFR0.33356047
160BCR0.33263138
161MAP3K110.32186732
162MELK0.31997105
163HCK0.31298722
164PAK10.30913509
165BRSK20.30518320

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.71507097
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.22459400
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18072329
4ECM-receptor interaction_Homo sapiens_hsa045122.12868020
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.11940296
6Synaptic vesicle cycle_Homo sapiens_hsa047212.05779980
7Malaria_Homo sapiens_hsa051442.00097454
8Hematopoietic cell lineage_Homo sapiens_hsa046401.98724309
9Platelet activation_Homo sapiens_hsa046111.92748360
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.83224849
11Primary immunodeficiency_Homo sapiens_hsa053401.76685534
12Legionellosis_Homo sapiens_hsa051341.64953499
13Long-term potentiation_Homo sapiens_hsa047201.63371120
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59893369
15Glioma_Homo sapiens_hsa052141.58930066
16Focal adhesion_Homo sapiens_hsa045101.58069097
17Pertussis_Homo sapiens_hsa051331.54526255
18Complement and coagulation cascades_Homo sapiens_hsa046101.53142551
19Amphetamine addiction_Homo sapiens_hsa050311.44942620
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42652531
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41139690
22Nicotine addiction_Homo sapiens_hsa050331.40298441
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39874774
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38850633
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.38735053
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37078983
27Measles_Homo sapiens_hsa051621.35594868
28T cell receptor signaling pathway_Homo sapiens_hsa046601.35195044
29Proteoglycans in cancer_Homo sapiens_hsa052051.30306980
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29484064
31Pancreatic cancer_Homo sapiens_hsa052121.29039606
32Amoebiasis_Homo sapiens_hsa051461.28242919
33Pentose phosphate pathway_Homo sapiens_hsa000301.26650576
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26645289
35Protein digestion and absorption_Homo sapiens_hsa049741.20846214
36Rheumatoid arthritis_Homo sapiens_hsa053231.20166083
37Vibrio cholerae infection_Homo sapiens_hsa051101.19606796
38Galactose metabolism_Homo sapiens_hsa000521.19399459
39Circadian entrainment_Homo sapiens_hsa047131.19253562
40Oxytocin signaling pathway_Homo sapiens_hsa049211.18490408
41Collecting duct acid secretion_Homo sapiens_hsa049661.18446458
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17597191
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16779814
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16427338
45Acute myeloid leukemia_Homo sapiens_hsa052211.15698687
46VEGF signaling pathway_Homo sapiens_hsa043701.14429822
47Bladder cancer_Homo sapiens_hsa052191.14226565
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14101822
49Gastric acid secretion_Homo sapiens_hsa049711.13923230
50Phagosome_Homo sapiens_hsa041451.13379817
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11217645
52Dopaminergic synapse_Homo sapiens_hsa047281.08484542
53Staphylococcus aureus infection_Homo sapiens_hsa051501.08232987
54TGF-beta signaling pathway_Homo sapiens_hsa043501.07919222
55Non-small cell lung cancer_Homo sapiens_hsa052231.07053519
56GnRH signaling pathway_Homo sapiens_hsa049121.07042858
57Dorso-ventral axis formation_Homo sapiens_hsa043201.06628514
58Oocyte meiosis_Homo sapiens_hsa041141.06283529
59mTOR signaling pathway_Homo sapiens_hsa041501.06177549
60Estrogen signaling pathway_Homo sapiens_hsa049151.06085988
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05799577
62Herpes simplex infection_Homo sapiens_hsa051681.05421021
63Influenza A_Homo sapiens_hsa051641.04825392
64Salivary secretion_Homo sapiens_hsa049701.04763230
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04194196
66Adherens junction_Homo sapiens_hsa045201.04184477
67Proteasome_Homo sapiens_hsa030501.03706363
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03618150
69Toxoplasmosis_Homo sapiens_hsa051451.03412891
70Small cell lung cancer_Homo sapiens_hsa052221.02780889
71Shigellosis_Homo sapiens_hsa051311.01574156
72Endocytosis_Homo sapiens_hsa041441.00694149
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99069738
74Tuberculosis_Homo sapiens_hsa051520.98817801
75Chronic myeloid leukemia_Homo sapiens_hsa052200.98790415
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.98672834
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98443042
78Endometrial cancer_Homo sapiens_hsa052130.97530164
79Chemokine signaling pathway_Homo sapiens_hsa040620.97422086
80Viral carcinogenesis_Homo sapiens_hsa052030.97159738
81Morphine addiction_Homo sapiens_hsa050320.95304373
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94158171
83ErbB signaling pathway_Homo sapiens_hsa040120.93944385
84Thyroid hormone synthesis_Homo sapiens_hsa049180.92694266
85Lysosome_Homo sapiens_hsa041420.92598940
86B cell receptor signaling pathway_Homo sapiens_hsa046620.92385066
87Renin secretion_Homo sapiens_hsa049240.91506799
88Colorectal cancer_Homo sapiens_hsa052100.91467082
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90676143
90cAMP signaling pathway_Homo sapiens_hsa040240.90125822
91Cholinergic synapse_Homo sapiens_hsa047250.88304043
92Hepatitis C_Homo sapiens_hsa051600.88224045
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88060465
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.87996218
95African trypanosomiasis_Homo sapiens_hsa051430.86041428
96Glutamatergic synapse_Homo sapiens_hsa047240.85248826
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85169045
98N-Glycan biosynthesis_Homo sapiens_hsa005100.84395773
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83070465
100Melanoma_Homo sapiens_hsa052180.82669477
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82186090
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81898316
103MicroRNAs in cancer_Homo sapiens_hsa052060.81652161
104Mismatch repair_Homo sapiens_hsa034300.79675010
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79196278
106Viral myocarditis_Homo sapiens_hsa054160.79190725
107Hepatitis B_Homo sapiens_hsa051610.78529263
108Cell cycle_Homo sapiens_hsa041100.77596000
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77329294
110Renin-angiotensin system_Homo sapiens_hsa046140.76884844
111Hippo signaling pathway_Homo sapiens_hsa043900.76093515
112TNF signaling pathway_Homo sapiens_hsa046680.75971237
113Thyroid cancer_Homo sapiens_hsa052160.74726096
114Choline metabolism in cancer_Homo sapiens_hsa052310.74722669
115Salmonella infection_Homo sapiens_hsa051320.74650217
116Gap junction_Homo sapiens_hsa045400.73527797
117Rap1 signaling pathway_Homo sapiens_hsa040150.72436454
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.72230705
119Fatty acid elongation_Homo sapiens_hsa000620.71781974
120Ovarian steroidogenesis_Homo sapiens_hsa049130.71443280
121Other glycan degradation_Homo sapiens_hsa005110.71404644
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69770568
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69746619
124MAPK signaling pathway_Homo sapiens_hsa040100.69703971
125Apoptosis_Homo sapiens_hsa042100.69646217
126Osteoclast differentiation_Homo sapiens_hsa043800.69556638
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67790263
128HTLV-I infection_Homo sapiens_hsa051660.67482456
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.67367369
130Epstein-Barr virus infection_Homo sapiens_hsa051690.67249788
131Insulin secretion_Homo sapiens_hsa049110.67249242
132DNA replication_Homo sapiens_hsa030300.66838443
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65807789
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65733307
135Renal cell carcinoma_Homo sapiens_hsa052110.65441771
136Antigen processing and presentation_Homo sapiens_hsa046120.65215120
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64929395
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64524356
139* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63678386
140Dilated cardiomyopathy_Homo sapiens_hsa054140.63024442
141Calcium signaling pathway_Homo sapiens_hsa040200.63009809
142Glutathione metabolism_Homo sapiens_hsa004800.62586511
143Leishmaniasis_Homo sapiens_hsa051400.62229029
144HIF-1 signaling pathway_Homo sapiens_hsa040660.62174729
145p53 signaling pathway_Homo sapiens_hsa041150.61941831
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61605365
147Prion diseases_Homo sapiens_hsa050200.61527626
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61356526
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60356967
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60274610
151Melanogenesis_Homo sapiens_hsa049160.60186211
152Prolactin signaling pathway_Homo sapiens_hsa049170.59780352
153Allograft rejection_Homo sapiens_hsa053300.58783177
154Graft-versus-host disease_Homo sapiens_hsa053320.45853393
155Pathways in cancer_Homo sapiens_hsa052000.45730746
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44882281
157Notch signaling pathway_Homo sapiens_hsa043300.41765757

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