VAC14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. VAC14 is a component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE (MIM 609414) and the PtdIns(3,5)P2 phosphatase FIG4 (MIM 609390). VAC14 functions as an activator of PIKFYVE (Sbrissa et al., 2007 [PubMed 17556371]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.42082970
2glycosphingolipid catabolic process (GO:0046479)4.32828530
3DNA unwinding involved in DNA replication (GO:0006268)4.26548097
4folic acid-containing compound biosynthetic process (GO:0009396)4.17269790
5protein localization to kinetochore (GO:0034501)4.05045461
6formation of translation preinitiation complex (GO:0001731)4.03939806
7nuclear pore organization (GO:0006999)4.03759756
8nuclear pore complex assembly (GO:0051292)3.96500219
9mitotic nuclear envelope disassembly (GO:0007077)3.95742585
10barbed-end actin filament capping (GO:0051016)3.87676659
11glycolipid catabolic process (GO:0019377)3.86465888
12negative regulation of erythrocyte differentiation (GO:0045647)3.84415190
13protein localization to endosome (GO:0036010)3.81904382
14pinocytosis (GO:0006907)3.79312291
15regulation of translational fidelity (GO:0006450)3.78701301
16heterochromatin organization (GO:0070828)3.77699157
17NIK/NF-kappaB signaling (GO:0038061)3.75389945
18cellular response to thyroid hormone stimulus (GO:0097067)3.71922099
19nuclear envelope disassembly (GO:0051081)3.66326787
20membrane disassembly (GO:0030397)3.66326787
21negative regulation of interleukin-12 production (GO:0032695)3.62746635
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.61333322
23regulation of early endosome to late endosome transport (GO:2000641)3.50761543
24DNA strand elongation involved in DNA replication (GO:0006271)3.45214426
25pre-miRNA processing (GO:0031054)3.43468087
26mannose metabolic process (GO:0006013)3.42444432
27IMP biosynthetic process (GO:0006188)3.41120611
28oligosaccharide catabolic process (GO:0009313)3.40959333
29negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.36381489
30protein localization to chromosome, centromeric region (GO:0071459)3.35385420
31DNA replication initiation (GO:0006270)3.35231530
32positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.30978996
33amino sugar catabolic process (GO:0046348)3.30642458
34response to thyroid hormone (GO:0097066)3.29791323
35positive regulation of Cdc42 GTPase activity (GO:0043089)3.27164420
36regulation of vitamin D biosynthetic process (GO:0060556)3.25721079
37ceramide catabolic process (GO:0046514)3.23951038
38DNA strand elongation (GO:0022616)3.23553635
39neutrophil activation involved in immune response (GO:0002283)3.22836898
40mitotic metaphase plate congression (GO:0007080)3.18966495
41macrophage activation involved in immune response (GO:0002281)3.18595440
42IMP metabolic process (GO:0046040)3.14701304
43pore complex assembly (GO:0046931)3.13506956
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08736021
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08099952
46DNA duplex unwinding (GO:0032508)3.05157464
47nuclear envelope organization (GO:0006998)3.04706314
48DNA geometric change (GO:0032392)3.04522880
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.03860618
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.03049533
51regulation of mononuclear cell migration (GO:0071675)3.02851469
52regulation of gene silencing by RNA (GO:0060966)3.02779968
53regulation of posttranscriptional gene silencing (GO:0060147)3.02779968
54regulation of gene silencing by miRNA (GO:0060964)3.02779968
55response to muramyl dipeptide (GO:0032495)3.02118773
56mitotic sister chromatid segregation (GO:0000070)3.01816416
57myeloid dendritic cell differentiation (GO:0043011)3.00126092
58positive regulation of chromosome segregation (GO:0051984)2.99953827
59membrane lipid catabolic process (GO:0046466)2.96377946
60nucleobase biosynthetic process (GO:0046112)2.96368871
61telomere maintenance via semi-conservative replication (GO:0032201)2.95536718
62modulation by symbiont of host cellular process (GO:0044068)2.94682564
63DNA replication-dependent nucleosome organization (GO:0034723)2.93880277
64DNA replication-dependent nucleosome assembly (GO:0006335)2.93880277
65sphingolipid catabolic process (GO:0030149)2.93052268
663-UTR-mediated mRNA stabilization (GO:0070935)2.92411812
67regulation of podosome assembly (GO:0071801)2.90227367
68regulation of translational termination (GO:0006449)2.89954612
69apoptotic cell clearance (GO:0043277)2.88035541
70T-helper 1 type immune response (GO:0042088)2.87981754
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.87183156
72regulation of cholesterol storage (GO:0010885)2.86959648
73negative regulation of histone methylation (GO:0031061)2.86779795
74positive regulation of SMAD protein import into nucleus (GO:0060391)2.83755483
75sister chromatid segregation (GO:0000819)2.82800200
76regulation of mitotic spindle organization (GO:0060236)2.82021794
77Golgi transport vesicle coating (GO:0048200)2.81699063
78COPI coating of Golgi vesicle (GO:0048205)2.81699063
79regulation of spindle organization (GO:0090224)2.80395358
80mitotic G1 DNA damage checkpoint (GO:0031571)2.79328482
81stress fiber assembly (GO:0043149)2.78886619
82mitotic chromosome condensation (GO:0007076)2.78283036
83chromatin assembly (GO:0031497)2.78040088
84regulation of leukocyte degranulation (GO:0043300)2.77345037
85folic acid metabolic process (GO:0046655)2.76936868
86mRNA stabilization (GO:0048255)2.76217384
87RNA stabilization (GO:0043489)2.76217384
88DNA replication checkpoint (GO:0000076)2.76056143
89adhesion of symbiont to host (GO:0044406)2.76053679
90germinal center formation (GO:0002467)2.75775294
91adhesion of symbiont to host cell (GO:0044650)2.74179294
92virion attachment to host cell (GO:0019062)2.74179294
93regulation of superoxide anion generation (GO:0032928)2.73882634
94positive regulation of chemokine biosynthetic process (GO:0045080)2.73189762
95metaphase plate congression (GO:0051310)2.70248169
96immunoglobulin mediated immune response (GO:0016064)2.70031156
97T cell apoptotic process (GO:0070231)2.69318165
98low-density lipoprotein particle clearance (GO:0034383)2.68188789
99regulation of sister chromatid cohesion (GO:0007063)2.67828751
100NLS-bearing protein import into nucleus (GO:0006607)2.66848581
101N-acetylneuraminate metabolic process (GO:0006054)2.66785826
102telomere maintenance via recombination (GO:0000722)2.66606634
103regulation of vitamin metabolic process (GO:0030656)2.64993165
104tetrahydrofolate metabolic process (GO:0046653)2.64805488
105regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63083630
106negative regulation of myeloid cell apoptotic process (GO:0033033)2.62433921
107pentose-phosphate shunt (GO:0006098)2.62163946
108regulation of monocyte differentiation (GO:0045655)2.60661246
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60566336
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59650686
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.59650686
112decidualization (GO:0046697)2.59516373
113maturation of SSU-rRNA (GO:0030490)2.59371996
114regulation of T-helper 1 cell differentiation (GO:0045625)2.59339778
115regulation of T-helper 2 cell differentiation (GO:0045628)2.58212073
116regulation of mast cell degranulation (GO:0043304)2.56365362
117myeloid dendritic cell activation (GO:0001773)2.56180009
118negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55690421
119regulation of chemokine biosynthetic process (GO:0045073)2.55660343
120maternal placenta development (GO:0001893)2.55547092
121regulation of membrane protein ectodomain proteolysis (GO:0051043)2.55333072
122activation of MAPKKK activity (GO:0000185)2.54922178
123hyaluronan catabolic process (GO:0030214)2.54520232
124mitotic recombination (GO:0006312)2.53858659
125dosage compensation (GO:0007549)2.53797413
126B cell mediated immunity (GO:0019724)2.53781552
127regulation of macrophage chemotaxis (GO:0010758)2.53736659
128regulation of histone H3-K9 methylation (GO:0051570)2.53592598
129apoptotic process involved in morphogenesis (GO:0060561)2.53076680
130response to UV-C (GO:0010225)2.52503778
131regulation of RNA export from nucleus (GO:0046831)2.52033067
132establishment of chromosome localization (GO:0051303)2.51941217
133positive regulation of type 2 immune response (GO:0002830)2.51520429
134ribosome biogenesis (GO:0042254)2.50755550
135mitotic G1/S transition checkpoint (GO:0044819)2.50631846
136endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.48872808
137dendritic cell differentiation (GO:0097028)2.48568323
138mitotic sister chromatid cohesion (GO:0007064)2.48264551
139positive regulation of mitotic sister chromatid separation (GO:1901970)2.47641061
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.47641061
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.47641061
142trophectodermal cell differentiation (GO:0001829)2.44320311
143negative regulation of gene silencing (GO:0060969)2.44247022
144positive regulation of leukocyte degranulation (GO:0043302)2.43875251
145response to laminar fluid shear stress (GO:0034616)2.43144642
146regulation of SMAD protein import into nucleus (GO:0060390)2.42242193
147snRNA metabolic process (GO:0016073)2.41730635
148regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41728403
149regulation of integrin activation (GO:0033623)2.40367747
150protein retention in ER lumen (GO:0006621)2.40078345
151positive regulation by symbiont of host defense response (GO:0052509)2.39565887
152modulation by symbiont of host defense response (GO:0052031)2.39565887
153modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39565887
154modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39565887
155positive regulation by organism of defense response of other organism involved in symbiotic interact2.39565887
156modulation by symbiont of host immune response (GO:0052553)2.39565887
157detection of molecule of bacterial origin (GO:0032490)2.39551119
158positive regulation of gamma-delta T cell activation (GO:0046645)2.39528624
159maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39478976
160antigen processing and presentation of endogenous antigen (GO:0019883)2.39452488
161telomere maintenance via telomere lengthening (GO:0010833)2.39435159
162positive regulation of antigen processing and presentation (GO:0002579)2.38944265
163ribosome assembly (GO:0042255)2.38355491
164intracellular estrogen receptor signaling pathway (GO:0030520)2.38284440
165translational initiation (GO:0006413)2.38028656
166cellular response to arsenic-containing substance (GO:0071243)2.37841760
167protein localization to chromosome (GO:0034502)2.37477484
168L-alpha-amino acid transmembrane transport (GO:1902475)2.36993358
169regulation of antigen processing and presentation (GO:0002577)2.36442078
170somatic hypermutation of immunoglobulin genes (GO:0016446)2.34945862
171somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34945862
172negative regulation of RNA splicing (GO:0033119)2.34102488
173negative regulation of nitric oxide biosynthetic process (GO:0045019)2.33585163
174positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33442427
175regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.32259312
176peptide catabolic process (GO:0043171)2.32110521
177regulation of gene silencing (GO:0060968)2.31989109
178determination of adult lifespan (GO:0008340)2.31707546
179modulation by virus of host process (GO:0019054)2.31533506
180interferon-gamma-mediated signaling pathway (GO:0060333)2.31284024
181adenosine receptor signaling pathway (GO:0001973)2.31015711
182mature B cell differentiation involved in immune response (GO:0002313)2.30901759
183positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.30901523
184glucose 6-phosphate metabolic process (GO:0051156)2.29822442
185regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29808593
186amyloid precursor protein catabolic process (GO:0042987)2.29382001
187regulation of mammary gland epithelial cell proliferation (GO:0033599)2.28755649
188positive regulation of extracellular matrix organization (GO:1903055)2.28535002
189negative regulation of cell size (GO:0045792)2.28464410
190maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.27690336
191positive regulation of cholesterol efflux (GO:0010875)2.25903792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.41488894
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86863447
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12527595
4MYC_22102868_ChIP-Seq_BL_Human2.96063255
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.89341518
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.85764884
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50093082
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44748823
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.29264651
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28643319
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23585133
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22597275
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21215327
14VDR_21846776_ChIP-Seq_THP-1_Human2.20211833
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.14741130
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97489651
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89692616
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84927816
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79300118
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71564189
21* E2F1_21310950_ChIP-Seq_MCF-7_Human1.67543601
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56705958
23XRN2_22483619_ChIP-Seq_HELA_Human1.56680620
24AR_21909140_ChIP-Seq_LNCAP_Human1.56522568
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56038347
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54685987
27KDM2B_26808549_Chip-Seq_K562_Human1.53829152
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53660633
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52455343
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52147901
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51670979
32TCF7_22412390_ChIP-Seq_EML_Mouse1.49726783
33CIITA_25753668_ChIP-Seq_RAJI_Human1.49622816
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49544435
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49361027
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49072817
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48565679
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47698945
39* TFEB_21752829_ChIP-Seq_HELA_Human1.45809322
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.45628518
41SPI1_23127762_ChIP-Seq_K562_Human1.43523244
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42700517
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41698398
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40483653
45MAF_26560356_Chip-Seq_TH1_Human1.38565546
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37769847
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37741355
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36390793
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.36219441
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.36125555
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35292614
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34766027
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34533968
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33949048
55KDM5A_27292631_Chip-Seq_BREAST_Human1.33462656
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.33081247
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.33049038
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32590903
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31218153
60UTX_26944678_Chip-Seq_JUKART_Human1.30412691
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29912778
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29545853
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28430517
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28270315
65CLOCK_20551151_ChIP-Seq_293T_Human1.27360718
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27151848
67KDM2B_26808549_Chip-Seq_DND41_Human1.27096107
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.26277297
69P68_20966046_ChIP-Seq_HELA_Human1.26168478
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.25593543
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25525178
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.23731113
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23329481
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23027922
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22538755
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22129662
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21616224
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19644736
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.19552852
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19223258
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19177011
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19060822
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18757079
84VDR_24763502_ChIP-Seq_THP-1_Human1.18134578
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17731127
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.17587408
87* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17565873
88* SPI1_23547873_ChIP-Seq_NB4_Human1.17515134
89E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17330019
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16744692
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16473663
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.16002748
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15990009
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15672864
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15503282
96GABP_19822575_ChIP-Seq_HepG2_Human1.14638680
97VDR_23849224_ChIP-Seq_CD4+_Human1.14132592
98SMC4_20622854_ChIP-Seq_HELA_Human1.13984841
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.13202691
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12416044
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12363660
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10945931
103* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09876877
104FOXP3_21729870_ChIP-Seq_TREG_Human1.09497840
105BCOR_27268052_Chip-Seq_Bcells_Human1.08891335
106* DCP1A_22483619_ChIP-Seq_HELA_Human1.08442770
107SCL_19346495_ChIP-Seq_HPC-7_Human1.08435259
108PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08287848
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07490575
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07378909
111ATF3_27146783_Chip-Seq_COLON_Human1.07265829
112* MYB_26560356_Chip-Seq_TH1_Human1.07205112
113ZNF263_19887448_ChIP-Seq_K562_Human1.06889063
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06841356
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.05239438
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04920438
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03945642
118MAF_26560356_Chip-Seq_TH2_Human1.03812717
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03578375
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02841411
121MYB_26560356_Chip-Seq_TH2_Human1.02324929
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02163192
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01818548
124BCL6_27268052_Chip-Seq_Bcells_Human1.01793673
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01260791
126KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01133466
127TTF2_22483619_ChIP-Seq_HELA_Human1.00721538
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99767616
129* TP53_22127205_ChIP-Seq_IMR90_Human0.99101431
130GATA1_19941826_ChIP-Seq_K562_Human0.98522909
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96615943
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96127187
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96080279
134NCOR1_26117541_ChIP-Seq_K562_Human0.95734293
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95286039
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94979634
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94467597
138* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93845959
139RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93122260
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92773421
141* IRF8_27001747_Chip-Seq_BMDM_Mouse0.92751506
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92512697
143LXR_22292898_ChIP-Seq_THP-1_Human0.92105172
144RACK7_27058665_Chip-Seq_MCF-7_Human0.91319442
145ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90625075
146MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90590258
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90283840
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88879386
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85638494
150PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85283868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.25381451
2MP0003693_abnormal_embryo_hatching3.07881106
3MP0010352_gastrointestinal_tract_polyps3.02761971
4MP0003111_abnormal_nucleus_morphology2.92417818
5MP0004957_abnormal_blastocyst_morpholog2.78456350
6MP0003705_abnormal_hypodermis_morpholog2.66049652
7MP0010094_abnormal_chromosome_stability2.62353851
8MP0003077_abnormal_cell_cycle2.56804148
9MP0002396_abnormal_hematopoietic_system2.43132360
10MP0003303_peritoneal_inflammation2.42266479
11MP0005076_abnormal_cell_differentiation2.32699118
12MP0010307_abnormal_tumor_latency2.32187659
13MP0002148_abnormal_hypersensitivity_rea2.21128118
14MP0009278_abnormal_bone_marrow2.10302312
15MP0001730_embryonic_growth_arrest2.03617633
16MP0008057_abnormal_DNA_replication1.96271818
17MP0008260_abnormal_autophagy1.95518535
18MP0000604_amyloidosis1.92067211
19MP0003075_altered_response_to1.91769611
20MP0009840_abnormal_foam_cell1.89712449
21MP0003300_gastrointestinal_ulcer1.81006336
22MP0000350_abnormal_cell_proliferation1.78214964
23MP0002139_abnormal_hepatobiliary_system1.77018245
24MP0009785_altered_susceptibility_to1.76668249
25MP0002998_abnormal_bone_remodeling1.74387395
26MP0001545_abnormal_hematopoietic_system1.71198879
27MP0005397_hematopoietic_system_phenotyp1.71198879
28MP0003436_decreased_susceptibility_to1.70754784
29MP0003566_abnormal_cell_adhesion1.66927150
30MP0002254_reproductive_system_inflammat1.64267423
31MP0004185_abnormal_adipocyte_glucose1.63119727
32MP0001533_abnormal_skeleton_physiology1.61017550
33MP0000685_abnormal_immune_system1.58728086
34MP0001835_abnormal_antigen_presentation1.56335488
35MP0009333_abnormal_splenocyte_physiolog1.55239141
36MP0003091_abnormal_cell_migration1.55159540
37MP0000490_abnormal_crypts_of1.51611062
38MP0005257_abnormal_intraocular_pressure1.51583592
39MP0002398_abnormal_bone_marrow1.48540068
40MP0001672_abnormal_embryogenesis/_devel1.47932132
41MP0005380_embryogenesis_phenotype1.47932132
42MP0001800_abnormal_humoral_immune1.47792059
43MP0003172_abnormal_lysosome_physiology1.45160866
44MP0003329_amyloid_beta_deposits1.44864759
45MP0003984_embryonic_growth_retardation1.44074021
46MP0004858_abnormal_nervous_system1.43091755
47MP0002088_abnormal_embryonic_growth/wei1.41650437
48MP0005058_abnormal_lysosome_morphology1.41108918
49MP0008007_abnormal_cellular_replicative1.40496020
50MP0000858_altered_metastatic_potential1.39808067
51MP0002086_abnormal_extraembryonic_tissu1.39134287
52MP0003763_abnormal_thymus_physiology1.37996656
53MP0004808_abnormal_hematopoietic_stem1.37122006
54MP0000689_abnormal_spleen_morphology1.36879028
55MP0002405_respiratory_system_inflammati1.35713587
56MP0001697_abnormal_embryo_size1.35620944
57MP0002722_abnormal_immune_system1.33831709
58MP0002019_abnormal_tumor_incidence1.33503890
59MP0004197_abnormal_fetal_growth/weight/1.33015977
60MP0005023_abnormal_wound_healing1.32119002
61MP0002452_abnormal_antigen_presenting1.31941792
62MP0002080_prenatal_lethality1.28876570
63MP0005464_abnormal_platelet_physiology1.27807833
64MP0010234_abnormal_vibrissa_follicle1.26542888
65MP0004233_abnormal_muscle_weight1.24094738
66MP0003724_increased_susceptibility_to1.23523655
67MP0000703_abnormal_thymus_morphology1.22588960
68MP0000313_abnormal_cell_death1.22422738
69MP0001853_heart_inflammation1.21226009
70MP0005310_abnormal_salivary_gland1.20010905
71MP0001790_abnormal_immune_system1.18744007
72MP0005387_immune_system_phenotype1.18744007
73MP0009764_decreased_sensitivity_to1.18395941
74MP0003191_abnormal_cellular_cholesterol1.17670885
75MP0008469_abnormal_protein_level1.17002936
76MP0002420_abnormal_adaptive_immunity1.16995353
77MP0002723_abnormal_immune_serum1.16288401
78MP0000716_abnormal_immune_system1.16184433
79MP0001819_abnormal_immune_cell1.15917243
80MP0002429_abnormal_blood_cell1.15566335
81MP0003690_abnormal_glial_cell1.15562591
82MP0002877_abnormal_melanocyte_morpholog1.15030541
83MP0005000_abnormal_immune_tolerance1.14072167
84MP0008058_abnormal_DNA_repair1.14059488
85MP0002084_abnormal_developmental_patter1.13458034
86MP0003806_abnormal_nucleotide_metabolis1.12360460
87MP0003448_altered_tumor_morphology1.11955102
88MP0005025_abnormal_response_to1.10537441
89MP0002085_abnormal_embryonic_tissue1.09569786
90MP0003828_pulmonary_edema1.07900946
91MP0008932_abnormal_embryonic_tissue1.07733608
92MP0001915_intracranial_hemorrhage1.07608210
93MP0003279_aneurysm1.05314718
94MP0009672_abnormal_birth_weight1.04876008
95MP0000733_abnormal_muscle_development1.04114092
96MP0002419_abnormal_innate_immunity1.03726931
97MP0004947_skin_inflammation1.03408128
98MP0002166_altered_tumor_susceptibility1.02154266
99MP0005166_decreased_susceptibility_to1.01887913
100MP0003183_abnormal_peptide_metabolism1.01264913
101MP0008438_abnormal_cutaneous_collagen1.00476992
102MP0003221_abnormal_cardiomyocyte_apopto0.98071130
103MP0001849_ear_inflammation0.97452752
104MP0008004_abnormal_stomach_pH0.96773062
105* MP0000371_diluted_coat_color0.93900682
106MP0006082_CNS_inflammation0.92541979
107MP0003567_abnormal_fetal_cardiomyocyte0.91966630
108MP0002006_tumorigenesis0.91154206
109MP0003453_abnormal_keratinocyte_physiol0.90159326
110MP0000598_abnormal_liver_morphology0.89854282
111MP0000609_abnormal_liver_physiology0.87934654
112MP0002796_impaired_skin_barrier0.87359690
113MP0003123_paternal_imprinting0.86851386
114MP0005409_darkened_coat_color0.86815246
115MP0002089_abnormal_postnatal_growth/wei0.84577375
116MP0000569_abnormal_digit_pigmentation0.84128087
117MP0005165_increased_susceptibility_to0.83575472
118* MP0003634_abnormal_glial_cell0.83354408
119MP0005390_skeleton_phenotype0.83279837
120MP0005167_abnormal_blood-brain_barrier0.83108892
121MP0005621_abnormal_cell_physiology0.82935407
122MP0001845_abnormal_inflammatory_respons0.82695763
123MP0010155_abnormal_intestine_physiology0.82180618
124MP0004510_myositis0.81918111
125MP0000920_abnormal_myelination0.81778886
126MP0005671_abnormal_response_to0.78874102
127MP0005666_abnormal_adipose_tissue0.78140292
128MP0003795_abnormal_bone_structure0.77899469
129MP0003656_abnormal_erythrocyte_physiolo0.77400250
130MP0005375_adipose_tissue_phenotype0.77195258
131MP0002332_abnormal_exercise_endurance0.76188375
132MP0000750_abnormal_muscle_regeneration0.75087000
133MP0003646_muscle_fatigue0.74703823
134MP0009703_decreased_birth_body0.73033538
135MP0003186_abnormal_redox_activity0.72779548
136MP0000477_abnormal_intestine_morphology0.72653649
137MP0008874_decreased_physiological_sensi0.71935378
138MP0000343_altered_response_to0.71747256
139MP0010630_abnormal_cardiac_muscle0.71713429
140MP0009763_increased_sensitivity_to0.69712106
141MP0001216_abnormal_epidermal_layer0.68069398
142MP0000747_muscle_weakness0.67113709

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.51766417
2Abnormality of liposaccharide metabolism (HP:0010968)6.51766417
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.51766417
4Dysostosis multiplex (HP:0000943)4.15114109
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.09459124
6Loss of speech (HP:0002371)3.74911156
7Vacuolated lymphocytes (HP:0001922)3.71109983
8Systemic lupus erythematosus (HP:0002725)3.66207385
9Abnormality of macrophages (HP:0004311)3.48534111
10Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29453481
11Abnormality of polysaccharide metabolism (HP:0011012)3.29453481
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29453481
13Vertebral compression fractures (HP:0002953)3.21873270
14Urinary glycosaminoglycan excretion (HP:0003541)3.12932702
15Mucopolysacchariduria (HP:0008155)3.12932702
16Nuclear cataract (HP:0100018)3.11976020
17Neurofibrillary tangles (HP:0002185)3.04336959
18Agnosia (HP:0010524)3.02395468
19Axonal loss (HP:0003447)2.89329385
20Ependymoma (HP:0002888)2.87780166
21Neuronal loss in central nervous system (HP:0002529)2.73271976
22Multiple enchondromatosis (HP:0005701)2.71953106
23Apathy (HP:0000741)2.70476906
24Diminished motivation (HP:0000745)2.67692364
25Birth length less than 3rd percentile (HP:0003561)2.65911645
26Cerebral inclusion bodies (HP:0100314)2.65046674
27Recurrent abscess formation (HP:0002722)2.60071751
28Achilles tendon contracture (HP:0001771)2.57543339
29Eczematoid dermatitis (HP:0000976)2.47007981
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46617259
31Pustule (HP:0200039)2.45470807
32Purpura (HP:0000979)2.44639478
33Basal cell carcinoma (HP:0002671)2.42275316
34Degeneration of anterior horn cells (HP:0002398)2.36053004
35Abnormality of the anterior horn cell (HP:0006802)2.36053004
36Personality changes (HP:0000751)2.35968320
37Abnormality of the fingertips (HP:0001211)2.34239241
38Spinal muscular atrophy (HP:0007269)2.32438310
39Abnormality of the Achilles tendon (HP:0005109)2.32083263
40Recurrent viral infections (HP:0004429)2.31952744
41Thoracic kyphosis (HP:0002942)2.30807557
42Disinhibition (HP:0000734)2.28803142
43Cellulitis (HP:0100658)2.28787669
44Recurrent bacterial skin infections (HP:0005406)2.28113663
45Selective tooth agenesis (HP:0001592)2.27645576
46Distal lower limb amyotrophy (HP:0008944)2.27533524
47Increased density of long bones (HP:0006392)2.26160548
48Spastic diplegia (HP:0001264)2.21701132
49Reticulocytopenia (HP:0001896)2.20526974
50Distal lower limb muscle weakness (HP:0009053)2.17907183
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.17872234
52Thin bony cortex (HP:0002753)2.16945360
53Supranuclear gaze palsy (HP:0000605)2.16885492
54Hepatosplenomegaly (HP:0001433)2.14721252
55Thrombocytosis (HP:0001894)2.14258469
56Upper motor neuron abnormality (HP:0002127)2.14133588
57Recurrent fungal infections (HP:0002841)2.12615836
58Asymmetric septal hypertrophy (HP:0001670)2.10497028
59Abnormality of the astrocytes (HP:0100707)2.10414215
60Astrocytoma (HP:0009592)2.10414215
61Bone pain (HP:0002653)2.09197807
62Prominent nose (HP:0000448)2.09135087
63IgM deficiency (HP:0002850)2.08917392
64High pitched voice (HP:0001620)2.08648580
65J-shaped sella turcica (HP:0002680)2.07695077
66Hyperacusis (HP:0010780)2.07690807
67Ulnar bowing (HP:0003031)2.07182627
68Pathologic fracture (HP:0002756)2.05747077
69Glomerulonephritis (HP:0000099)2.04309988
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03530834
71Mutism (HP:0002300)2.03451636
72Prolonged neonatal jaundice (HP:0006579)2.03071353
73Obstructive lung disease (HP:0006536)2.02979313
74Chronic obstructive pulmonary disease (HP:0006510)2.02979313
75Progressive neurologic deterioration (HP:0002344)2.02743616
76Abnormal neuron morphology (HP:0012757)2.02226030
77Abnormality of the motor neurons (HP:0002450)2.02226030
78Spontaneous hematomas (HP:0007420)2.00291095
79Metaphyseal cupping (HP:0003021)1.99895360
80Increased cerebral lipofuscin (HP:0011813)1.99743188
81Amyloidosis (HP:0011034)1.98416916
82Cervical subluxation (HP:0003308)1.98352199
83Cerebral aneurysm (HP:0004944)1.96924744
84Rectal prolapse (HP:0002035)1.95550799
85Mediastinal lymphadenopathy (HP:0100721)1.95520581
86Dementia (HP:0000726)1.94654509
87Petechiae (HP:0000967)1.94375902
88Broad face (HP:0000283)1.93992282
89Abnormality of complement system (HP:0005339)1.93129397
90Elevated erythrocyte sedimentation rate (HP:0003565)1.92274321
91Gingivitis (HP:0000230)1.90566014
92Protrusio acetabuli (HP:0003179)1.89821847
93Genu recurvatum (HP:0002816)1.89783127
94Increased serum ferritin (HP:0003281)1.89275912
95Absent thumb (HP:0009777)1.88009941
96Gastrointestinal inflammation (HP:0004386)1.87781673
97Rhabdomyosarcoma (HP:0002859)1.87570903
98Angiofibromas (HP:0010615)1.87236798
99Adenoma sebaceum (HP:0009720)1.87236798
100Autoimmune thrombocytopenia (HP:0001973)1.87226048
101Ragged-red muscle fibers (HP:0003200)1.86948148
102Abnormality of reticulocytes (HP:0004312)1.85627775
103Deviation of the thumb (HP:0009603)1.85473651
104Trismus (HP:0000211)1.85455217
105Myocardial infarction (HP:0001658)1.85427505
106Interstitial pulmonary disease (HP:0006530)1.85186960
107Colon cancer (HP:0003003)1.85006244
108Abnormality of cells of the erythroid lineage (HP:0012130)1.83779544
109Cortical dysplasia (HP:0002539)1.83361648
110Proximal placement of thumb (HP:0009623)1.82519996
111Hypertensive crisis (HP:0100735)1.82477901
112Amaurosis fugax (HP:0100576)1.81190035
113Abnormal platelet function (HP:0011869)1.80846739
114Impaired platelet aggregation (HP:0003540)1.80846739
115Hand muscle atrophy (HP:0009130)1.80832823
116Chromsome breakage (HP:0040012)1.80098087
117Increased connective tissue (HP:0009025)1.79635460
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.79163212
119Colitis (HP:0002583)1.78326262
120Facial hemangioma (HP:0000329)1.78260724
121Abnormality of pyrimidine metabolism (HP:0004353)1.77440786
122Cardiomegaly (HP:0001640)1.77349511
123Abnormality of lateral ventricle (HP:0030047)1.77140923
124Increased IgE level (HP:0003212)1.76968882
125Cafe-au-lait spot (HP:0000957)1.75447559
126Poikiloderma (HP:0001029)1.75210550
127Urethral obstruction (HP:0000796)1.74726861
128Hyperparathyroidism (HP:0000843)1.74213570
129Malnutrition (HP:0004395)1.73874415
130Medulloblastoma (HP:0002885)1.73796850
131Segmental peripheral demyelination/remyelination (HP:0003481)1.73009663
132Complement deficiency (HP:0004431)1.72521699
133Breast hypoplasia (HP:0003187)1.71470613
134Polygenic inheritance (HP:0010982)1.70567979
135Esophageal varix (HP:0002040)1.69983212
136Myelodysplasia (HP:0002863)1.68789781
137Squamous cell carcinoma (HP:0002860)1.68781459
138Inflammation of the large intestine (HP:0002037)1.68378559
139Abnormality of iron homeostasis (HP:0011031)1.68201860
140Malignant gastrointestinal tract tumors (HP:0006749)1.67668125
141Gastrointestinal carcinoma (HP:0002672)1.67668125
142Upper limb amyotrophy (HP:0009129)1.66771558
143Distal upper limb amyotrophy (HP:0007149)1.66771558
144Abnormality of transition element cation homeostasis (HP:0011030)1.66695092
145Restrictive lung disease (HP:0002091)1.66373276
146Short humerus (HP:0005792)1.66328000
147Abnormality of the thoracic spine (HP:0100711)1.66013843
148Reticulocytosis (HP:0001923)1.65996975
149Neoplasm of the oral cavity (HP:0100649)1.65777615
150Neoplasm of striated muscle (HP:0009728)1.65473626
151Pseudobulbar signs (HP:0002200)1.65227993
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.64953681
153Cutaneous melanoma (HP:0012056)1.64344792
154Hemorrhage of the eye (HP:0011885)1.64070113
155Aplasia/hypoplasia of the humerus (HP:0006507)1.63835478
156Abnormality of the lumbar spine (HP:0100712)1.63725133
157Recurrent gram-negative bacterial infections (HP:0005420)1.63459860
158Patellar aplasia (HP:0006443)1.63403305
159Osteomyelitis (HP:0002754)1.63131105
160Spondylolisthesis (HP:0003302)1.62429157
161Long eyelashes (HP:0000527)1.61845097
162Muscle fibrillation (HP:0010546)1.61301554
163Osteolytic defects of the phalanges of the hand (HP:0009771)1.60571404
164Osteolytic defects of the hand bones (HP:0009699)1.60571404
165Oral leukoplakia (HP:0002745)1.60385366
166Skin tags (HP:0010609)1.60204973
167Nasal polyposis (HP:0100582)1.59765552
168Leukopenia (HP:0001882)1.59376418
169Joint stiffness (HP:0001387)1.58379294
170Premature rupture of membranes (HP:0001788)1.57554061
171Natal tooth (HP:0000695)1.57495110
172Emphysema (HP:0002097)1.57196051
173Abnormality of the nasal mucosa (HP:0000433)1.56893140
174Bulbar palsy (HP:0001283)1.53580639
175Lower limb amyotrophy (HP:0007210)1.53246192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.33059450
2TRIB33.43996214
3CDK123.36985529
4PKN23.00054676
5MAP3K102.96328727
6EEF2K2.92670965
7MAP4K12.83853724
8CDC72.76105925
9PRPF4B2.75437738
10ERN12.30406765
11SMG12.25889847
12NEK22.20390529
13STK102.15542820
14SCYL21.97088956
15MAP3K141.87438244
16WEE11.75965895
17DDR21.74032784
18TESK11.68272495
19MAP3K81.62982587
20CDC42BPA1.60609059
21RPS6KA41.56043541
22CDK41.52755761
23TYK21.52227773
24NME21.52134927
25MAP2K31.51896746
26MAP3K131.51042539
27LRRK21.50972686
28TTK1.48472165
29TTN1.46371235
30RPS6KB21.42000439
31MAP3K111.41211575
32TAOK11.37771053
33MOS1.37391161
34TGFBR21.36564885
35GRK71.33914716
36RIPK41.33843812
37BUB11.32300973
38JAK31.28016948
39ALK1.27869885
40MAP3K11.27518523
41CDK71.27442326
42ICK1.24567015
43NEK11.23965372
44ZAP701.22991890
45CDK61.16662233
46MATK1.16428404
47MTOR1.15431407
48BLK1.14599976
49PTK61.13122941
50GRK61.12258225
51FGR1.11496178
52IRAK41.10907282
53TAOK21.10179337
54ARAF1.08366671
55PAK41.08355482
56PIM11.07653977
57CAMK1D1.03073790
58ATR0.98482959
59EPHA20.97588661
60BMX0.97183336
61EPHB10.94925422
62PLK10.92487616
63IRAK20.92468962
64ABL20.91481873
65MARK20.90011269
66TBK10.89989150
67RPS6KA20.89180020
68EIF2AK10.87486814
69CHEK10.84008554
70FLT30.83657238
71CSF1R0.83371006
72CHEK20.82874158
73PDPK10.82672889
74PRKD20.82662845
75BRD40.82323352
76AURKB0.82052749
77MST1R0.81828907
78STK30.78572403
79MAP3K30.76790854
80BTK0.76758850
81TSSK60.76233847
82LATS20.72869978
83STK40.71483703
84PIM20.70347426
85MAP3K60.69210059
86MAP3K50.68489850
87RPS6KL10.67997032
88RPS6KC10.67997032
89LIMK10.67841116
90CSK0.67605398
91KSR20.67159979
92SIK10.67151004
93PTK20.66943440
94CDK20.66883002
95HCK0.65603230
96DYRK30.65017711
97TESK20.64584327
98LATS10.64461619
99SIK20.64303318
100RIPK10.64006576
101CHUK0.63507848
102PDGFRA0.62759042
103KDR0.61938917
104TYRO30.60470329
105SIK30.59631245
106ATM0.59582726
107FGFR40.55707303
108JAK20.55248497
109MAPKAPK30.54386625
110PASK0.54252166
111KIT0.54106422
112SYK0.53044337
113LMTK20.52641761
114HIPK20.52092108
115PAK20.51587000
116AURKA0.51468600
117ACVR1B0.50689038
118MELK0.50332487
119TGFBR10.50137105
120MAP3K90.50127816
121PRKG20.49584786
122IKBKE0.48318996
123PAK10.48255731
124LCK0.47866282
125CDK90.47697711
126PDK10.47610132
127IKBKB0.47608920
128DMPK0.47439016
129CAMK1G0.47271896
130JAK10.46719752
131BRSK20.44182547
132RPS6KA60.44154852
133MARK30.43929589
134BRAF0.43752722
135RPS6KA10.42967483
136FES0.42196696
137AKT20.40780666
138MAPK110.40441250
139EGFR0.40335264
140CLK10.40043703
141PRKD30.38943110
142MAPKAPK20.38817251
143DAPK30.36434416
144LYN0.36416744
145NEK90.34569828
146MAP2K20.33054276

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.19079118
2DNA replication_Homo sapiens_hsa030303.59415173
3Mismatch repair_Homo sapiens_hsa034302.94731485
4One carbon pool by folate_Homo sapiens_hsa006702.72496413
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43170745
6Base excision repair_Homo sapiens_hsa034102.41387294
7RNA transport_Homo sapiens_hsa030132.38113895
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.13060002
9Cell cycle_Homo sapiens_hsa041102.02647762
10Spliceosome_Homo sapiens_hsa030401.95447039
11Rheumatoid arthritis_Homo sapiens_hsa053231.78761642
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77480789
13Allograft rejection_Homo sapiens_hsa053301.65153303
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54589114
15Salmonella infection_Homo sapiens_hsa051321.51389338
16Prion diseases_Homo sapiens_hsa050201.51095586
17Chronic myeloid leukemia_Homo sapiens_hsa052201.49434358
18Homologous recombination_Homo sapiens_hsa034401.48319265
19Antigen processing and presentation_Homo sapiens_hsa046121.48253568
20Pertussis_Homo sapiens_hsa051331.48161746
21B cell receptor signaling pathway_Homo sapiens_hsa046621.47087599
22Leishmaniasis_Homo sapiens_hsa051401.46019866
23Asthma_Homo sapiens_hsa053101.45019656
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42751976
25Nucleotide excision repair_Homo sapiens_hsa034201.41503835
26Malaria_Homo sapiens_hsa051441.38484089
27p53 signaling pathway_Homo sapiens_hsa041151.37566151
28Phagosome_Homo sapiens_hsa041451.35343027
29Herpes simplex infection_Homo sapiens_hsa051681.30126870
30Biosynthesis of amino acids_Homo sapiens_hsa012301.30098622
31Graft-versus-host disease_Homo sapiens_hsa053321.29629950
32Autoimmune thyroid disease_Homo sapiens_hsa053201.28270509
33RNA polymerase_Homo sapiens_hsa030201.27244877
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.26581507
35Galactose metabolism_Homo sapiens_hsa000521.24562200
36Ribosome_Homo sapiens_hsa030101.23513323
37mRNA surveillance pathway_Homo sapiens_hsa030151.21707657
38Pyrimidine metabolism_Homo sapiens_hsa002401.21057413
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19895804
40* Viral carcinogenesis_Homo sapiens_hsa052031.19011536
41Apoptosis_Homo sapiens_hsa042101.18674405
42Acute myeloid leukemia_Homo sapiens_hsa052211.18201992
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17751450
44Epstein-Barr virus infection_Homo sapiens_hsa051691.16603851
45Vibrio cholerae infection_Homo sapiens_hsa051101.16075130
46Legionellosis_Homo sapiens_hsa051341.15001354
47Lysine degradation_Homo sapiens_hsa003101.14891983
48Small cell lung cancer_Homo sapiens_hsa052221.13292189
49Fructose and mannose metabolism_Homo sapiens_hsa000511.12772982
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10906203
51Osteoclast differentiation_Homo sapiens_hsa043801.10386042
52mTOR signaling pathway_Homo sapiens_hsa041501.08719717
53Pentose phosphate pathway_Homo sapiens_hsa000301.08598621
54Measles_Homo sapiens_hsa051621.05899119
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05690918
56Selenocompound metabolism_Homo sapiens_hsa004501.05139315
57Viral myocarditis_Homo sapiens_hsa054161.05109234
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.04903431
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04174579
60Hepatitis C_Homo sapiens_hsa051601.01471826
61MicroRNAs in cancer_Homo sapiens_hsa052061.01174681
62Amoebiasis_Homo sapiens_hsa051461.00183365
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00017544
64Primary immunodeficiency_Homo sapiens_hsa053400.98670381
65Type I diabetes mellitus_Homo sapiens_hsa049400.98344553
66Shigellosis_Homo sapiens_hsa051310.96010358
67* HTLV-I infection_Homo sapiens_hsa051660.95842833
68Non-homologous end-joining_Homo sapiens_hsa034500.92208607
69Hepatitis B_Homo sapiens_hsa051610.91835917
70Toxoplasmosis_Homo sapiens_hsa051450.91320883
71RNA degradation_Homo sapiens_hsa030180.89693132
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.86629746
73African trypanosomiasis_Homo sapiens_hsa051430.84579181
74Influenza A_Homo sapiens_hsa051640.84501528
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.83594878
76Carbon metabolism_Homo sapiens_hsa012000.83449078
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83200760
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.82398434
79Pancreatic cancer_Homo sapiens_hsa052120.82143808
80Staphylococcus aureus infection_Homo sapiens_hsa051500.81812771
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81391909
82Non-small cell lung cancer_Homo sapiens_hsa052230.81211755
83Chemokine signaling pathway_Homo sapiens_hsa040620.79821789
84Hematopoietic cell lineage_Homo sapiens_hsa046400.75410462
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.75285861
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74394247
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72728841
88Thyroid cancer_Homo sapiens_hsa052160.72519118
89Notch signaling pathway_Homo sapiens_hsa043300.71843149
90Fanconi anemia pathway_Homo sapiens_hsa034600.71722300
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70914600
92Renal cell carcinoma_Homo sapiens_hsa052110.70428186
93Endocytosis_Homo sapiens_hsa041440.69739148
94Colorectal cancer_Homo sapiens_hsa052100.69142958
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68919007
96Lysosome_Homo sapiens_hsa041420.66983497
97VEGF signaling pathway_Homo sapiens_hsa043700.66809161
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66720401
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66555600
100Sphingolipid metabolism_Homo sapiens_hsa006000.66397171
101Insulin resistance_Homo sapiens_hsa049310.66004662
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.65966200
103Tuberculosis_Homo sapiens_hsa051520.65678826
104Adherens junction_Homo sapiens_hsa045200.64612205
105Prolactin signaling pathway_Homo sapiens_hsa049170.64599716
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64414653
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62442912
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.62131580
109Bladder cancer_Homo sapiens_hsa052190.62030958
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.61873449
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61002083
112Nitrogen metabolism_Homo sapiens_hsa009100.60400058
113Proteoglycans in cancer_Homo sapiens_hsa052050.58533776
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57991704
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57443637
116GnRH signaling pathway_Homo sapiens_hsa049120.56201853
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.55826163
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.55389508
119T cell receptor signaling pathway_Homo sapiens_hsa046600.55310325
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54896616
121TNF signaling pathway_Homo sapiens_hsa046680.54640441
122Insulin signaling pathway_Homo sapiens_hsa049100.54559685
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54513817
124Collecting duct acid secretion_Homo sapiens_hsa049660.53962253
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52546563
126HIF-1 signaling pathway_Homo sapiens_hsa040660.52215393
127Folate biosynthesis_Homo sapiens_hsa007900.52015946
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50366656
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49995467
130Arginine biosynthesis_Homo sapiens_hsa002200.49143605
131Systemic lupus erythematosus_Homo sapiens_hsa053220.47747181
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.46967016
133Proteasome_Homo sapiens_hsa030500.46282776
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46275316
135Complement and coagulation cascades_Homo sapiens_hsa046100.46088874
136Endometrial cancer_Homo sapiens_hsa052130.45777050
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45528080
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44978006
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43788088
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43766991
141AMPK signaling pathway_Homo sapiens_hsa041520.43347533
142Glioma_Homo sapiens_hsa052140.42455358
143ErbB signaling pathway_Homo sapiens_hsa040120.42166764
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40623197
145Platelet activation_Homo sapiens_hsa046110.39721432

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