VAMP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.79148687
2DNA deamination (GO:0045006)7.13202515
3viral transcription (GO:0019083)6.48521902
4translational termination (GO:0006415)6.18754551
5ribosomal small subunit biogenesis (GO:0042274)5.59812337
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.39338341
7translational elongation (GO:0006414)5.38802135
8platelet dense granule organization (GO:0060155)5.26625590
9cotranslational protein targeting to membrane (GO:0006613)5.24678309
10protein targeting to ER (GO:0045047)5.23416426
11definitive hemopoiesis (GO:0060216)5.08890696
12protein localization to endoplasmic reticulum (GO:0070972)5.01411913
13maturation of SSU-rRNA (GO:0030490)4.99577412
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.99320211
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.72864693
16viral life cycle (GO:0019058)4.71908637
17cellular protein complex disassembly (GO:0043624)4.62610243
18translational initiation (GO:0006413)4.35652490
19telomere maintenance via semi-conservative replication (GO:0032201)4.34687763
20response to interferon-beta (GO:0035456)4.20591610
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.17469092
22immunoglobulin mediated immune response (GO:0016064)4.08694790
23protein complex disassembly (GO:0043241)4.02547013
24cytidine deamination (GO:0009972)3.91538336
25cytidine metabolic process (GO:0046087)3.91538336
26cytidine catabolic process (GO:0006216)3.91538336
27macromolecular complex disassembly (GO:0032984)3.77664024
28DNA strand elongation involved in DNA replication (GO:0006271)3.75475770
29endothelium development (GO:0003158)3.75172917
30ribosomal large subunit biogenesis (GO:0042273)3.67728834
31negative regulation of erythrocyte differentiation (GO:0045647)3.64283297
32DNA strand elongation (GO:0022616)3.63360992
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63166715
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.62393806
35telomere maintenance via recombination (GO:0000722)3.58560927
36iron-sulfur cluster assembly (GO:0016226)3.53175127
37metallo-sulfur cluster assembly (GO:0031163)3.53175127
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53065345
39secretory granule organization (GO:0033363)3.50275795
40mRNA catabolic process (GO:0006402)3.47893914
41ribonucleoprotein complex biogenesis (GO:0022613)3.47454549
42negative regulation of nitric-oxide synthase activity (GO:0051001)3.47428113
43translation (GO:0006412)3.46834704
44respiratory chain complex IV assembly (GO:0008535)3.45994352
45proteasome assembly (GO:0043248)3.45784377
46pseudouridine synthesis (GO:0001522)3.43986036
47megakaryocyte development (GO:0035855)3.42100942
48antigen processing and presentation via MHC class Ib (GO:0002475)3.41967383
49erythrocyte maturation (GO:0043249)3.40251507
50protein targeting to membrane (GO:0006612)3.39373138
51daunorubicin metabolic process (GO:0044597)3.37934834
52polyketide metabolic process (GO:0030638)3.37934834
53doxorubicin metabolic process (GO:0044598)3.37934834
54negative regulation of nitric oxide biosynthetic process (GO:0045019)3.37284892
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.35063840
56heme biosynthetic process (GO:0006783)3.29893491
57RNA catabolic process (GO:0006401)3.29602179
58DNA replication initiation (GO:0006270)3.29519872
59regulation of antigen processing and presentation (GO:0002577)3.25526152
60type I interferon signaling pathway (GO:0060337)3.24280420
61cellular response to type I interferon (GO:0071357)3.24280420
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22310206
63response to type I interferon (GO:0034340)3.20988251
64telomere maintenance via telomere lengthening (GO:0010833)3.19287164
65embryonic hemopoiesis (GO:0035162)3.16413094
66regulation of erythrocyte differentiation (GO:0045646)3.15138726
67B cell mediated immunity (GO:0019724)3.12393837
68response to interferon-alpha (GO:0035455)3.11826225
69cellular response to interferon-beta (GO:0035458)3.11577470
70mature B cell differentiation involved in immune response (GO:0002313)3.08677608
71purine-containing compound salvage (GO:0043101)3.07290703
72mitotic recombination (GO:0006312)3.06689904
73positive regulation of granulocyte differentiation (GO:0030854)3.06074645
74positive regulation of natural killer cell differentiation (GO:0032825)3.05414917
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05304228
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05304228
77blood vessel maturation (GO:0001955)3.04028602
78positive regulation of antigen processing and presentation (GO:0002579)3.02178306
79positive thymic T cell selection (GO:0045059)3.01082562
80cellular component biogenesis (GO:0044085)2.99599431
81interferon-gamma-mediated signaling pathway (GO:0060333)2.98784306
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98472817
83membrane raft organization (GO:0031579)2.94574303
84neutrophil activation involved in immune response (GO:0002283)2.93193808
85phospholipid scrambling (GO:0017121)2.93018015
86positive regulation of interleukin-8 secretion (GO:2000484)2.92414843
87angiogenesis involved in wound healing (GO:0060055)2.91166035
88CENP-A containing nucleosome assembly (GO:0034080)2.89802742
89cytochrome complex assembly (GO:0017004)2.89725889
90positive regulation of B cell differentiation (GO:0045579)2.88899000
91regulation of T cell tolerance induction (GO:0002664)2.88659628
92negative regulation of cell killing (GO:0031342)2.88255197
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88255197
94rRNA processing (GO:0006364)2.88225760
95granulocyte differentiation (GO:0030851)2.87669544
96oxidative phosphorylation (GO:0006119)2.86888378
97positive regulation of gamma-delta T cell activation (GO:0046645)2.85569212
98heme metabolic process (GO:0042168)2.83479368
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82447824
100nucleotide-excision repair, DNA gap filling (GO:0006297)2.81683052
101endosome to melanosome transport (GO:0035646)2.79721472
102endosome to pigment granule transport (GO:0043485)2.79721472
103rRNA metabolic process (GO:0016072)2.77154345
104aerobic respiration (GO:0009060)2.77071938
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76505282
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72662422
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.72662422
108NADH dehydrogenase complex assembly (GO:0010257)2.72662422
109lymphoid progenitor cell differentiation (GO:0002320)2.70658792
110detection of bacterium (GO:0016045)2.70497510
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69769723
112chromatin remodeling at centromere (GO:0031055)2.69104250
113tRNA methylation (GO:0030488)2.68190400
114detection of other organism (GO:0098543)2.67450146
115regulation of interleukin-8 secretion (GO:2000482)2.66941868
116regulation of metalloenzyme activity (GO:0048552)2.65629113
117formation of translation preinitiation complex (GO:0001731)2.65312500
118negative regulation of viral genome replication (GO:0045071)2.65270640
119pyrimidine nucleoside catabolic process (GO:0046135)2.64924987
120regulation of regulatory T cell differentiation (GO:0045589)2.64447455
121regulation of macrophage chemotaxis (GO:0010758)2.62974640
122regulation of skeletal muscle contraction (GO:0014819)2.61869742
123protein complex biogenesis (GO:0070271)2.61816951
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.61784381
125heart contraction (GO:0060047)2.60855223
126heart process (GO:0003015)2.60855223
127mitochondrial respiratory chain complex assembly (GO:0033108)2.59719748
128T cell homeostasis (GO:0043029)2.59203022
129ribosome biogenesis (GO:0042254)2.58265202
130termination of RNA polymerase III transcription (GO:0006386)2.57614927
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.57614927
132negative regulation of interleukin-12 production (GO:0032695)2.57034886
133cellular response to thyroid hormone stimulus (GO:0097067)2.57021838
134T cell migration (GO:0072678)2.56944346
135regulation of tolerance induction (GO:0002643)2.56436870
136deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.54443729
137lymphocyte chemotaxis (GO:0048247)2.54011309
138negative regulation of bone mineralization (GO:0030502)2.53910811
139regulation of interferon-beta biosynthetic process (GO:0045357)2.53908616
140viral mRNA export from host cell nucleus (GO:0046784)2.53766633
141positive regulation of T cell mediated cytotoxicity (GO:0001916)2.51169578
142positive regulation of interleukin-1 beta secretion (GO:0050718)2.50186369
143negative regulation of monooxygenase activity (GO:0032769)2.49695477
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48331870
145positive regulation of respiratory burst (GO:0060267)2.48112325
146erythrocyte development (GO:0048821)2.47787784
147positive regulation of tolerance induction (GO:0002645)2.47761424
148cellular response to interferon-gamma (GO:0071346)2.46599971
149positive regulation of interleukin-1 secretion (GO:0050716)2.46227886
150phagocytosis, engulfment (GO:0006911)2.45323412
151regulation of B cell receptor signaling pathway (GO:0050855)2.45157515
152negative regulation of innate immune response (GO:0045824)2.44991045
153positive regulation by symbiont of host defense response (GO:0052509)2.44503493
154modulation by symbiont of host defense response (GO:0052031)2.44503493
155modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44503493
156modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44503493
157positive regulation by organism of defense response of other organism involved in symbiotic interact2.44503493
158modulation by symbiont of host immune response (GO:0052553)2.44503493
159tRNA modification (GO:0006400)2.43807470
160regulation of necrotic cell death (GO:0010939)2.42990578
161porphyrin-containing compound biosynthetic process (GO:0006779)2.42359233
162regulation of T-helper 1 cell differentiation (GO:0045625)2.42120187
163microglial cell activation (GO:0001774)2.41883373
164response to interferon-gamma (GO:0034341)2.41391718
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41215588
166regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.41096719
167antigen processing and presentation of endogenous antigen (GO:0019883)2.41021200
168positive regulation of type 2 immune response (GO:0002830)2.40875082
169actin nucleation (GO:0045010)2.40566571
170regulation of gamma-delta T cell activation (GO:0046643)2.38844930
171regulation of interleukin-1 secretion (GO:0050704)2.38395526
172positive regulation of interleukin-1 beta production (GO:0032731)2.38160497
173regulation of mononuclear cell migration (GO:0071675)2.37413285
174regulation of integrin-mediated signaling pathway (GO:2001044)2.36764253
175regulation of interleukin-1 beta secretion (GO:0050706)2.35899835
176regulation of T cell mediated cytotoxicity (GO:0001914)2.33119142
177regulation of T cell migration (GO:2000404)2.32925436
178negative regulation of stress fiber assembly (GO:0051497)2.32760660
179negative T cell selection (GO:0043383)2.30063917
180regulation of type 2 immune response (GO:0002828)2.29053054
181negative regulation of leukocyte apoptotic process (GO:2000107)2.28758998
182negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.28393380
183positive regulation of defense response to virus by host (GO:0002230)2.27568464
184regulation of gamma-delta T cell differentiation (GO:0045586)2.26859980
185actin-myosin filament sliding (GO:0033275)2.26512247
186muscle filament sliding (GO:0030049)2.26512247
187positive T cell selection (GO:0043368)2.26279365
188T cell costimulation (GO:0031295)2.26170390
189positive regulation of interleukin-1 production (GO:0032732)2.25910888
190positive regulation of lymphocyte migration (GO:2000403)2.24763254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.99223434
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04767275
3SCL_19346495_ChIP-Seq_HPC-7_Human3.75773895
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.72904397
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.55506975
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26781654
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14920648
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.02674189
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.93494980
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.73935269
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70784486
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.62589996
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.60992592
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60090539
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54326698
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.48081607
17GATA1_22025678_ChIP-Seq_K562_Human2.47193243
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45789323
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44970415
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43890701
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42426460
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.41849305
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.38375435
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.36847160
25* GATA2_21666600_ChIP-Seq_HMVEC_Human2.31987743
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28459761
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24080238
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.18006891
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.17261011
30IRF8_22096565_ChIP-ChIP_GC-B_Human2.14359395
31ERG_20887958_ChIP-Seq_HPC-7_Mouse2.12231989
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12149013
33VDR_23849224_ChIP-Seq_CD4+_Human2.12074225
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.09899612
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09787420
36MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08293799
37HOXB4_20404135_ChIP-ChIP_EML_Mouse2.06629561
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06547528
39BP1_19119308_ChIP-ChIP_Hs578T_Human2.05542774
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01282097
41E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00936241
42RUNX_20019798_ChIP-Seq_JUKART_Human1.99764918
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.94753748
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91972912
45FOXP3_21729870_ChIP-Seq_TREG_Human1.91653054
46XRN2_22483619_ChIP-Seq_HELA_Human1.89312690
47* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89283793
48GATA1_22383799_ChIP-Seq_G1ME_Mouse1.88893484
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84452689
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79288802
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78876776
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77617023
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75909277
54* SPI1_23547873_ChIP-Seq_NB4_Human1.75784033
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74591266
56* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72899853
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69726358
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68549803
59MYC_22102868_ChIP-Seq_BL_Human1.67540335
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65187415
61DCP1A_22483619_ChIP-Seq_HELA_Human1.65062170
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63919055
63VDR_21846776_ChIP-Seq_THP-1_Human1.63590452
64GABP_19822575_ChIP-Seq_HepG2_Human1.57642909
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54568473
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54295052
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.53267652
68ELK1_19687146_ChIP-ChIP_HELA_Human1.52467132
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52260858
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51214537
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51150389
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48822166
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47995051
74TTF2_22483619_ChIP-Seq_HELA_Human1.47346601
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46533603
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46130884
77CIITA_25753668_ChIP-Seq_RAJI_Human1.45993729
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42744317
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.42597619
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39545026
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.39122272
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37784221
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37345403
84* SPI1_23127762_ChIP-Seq_K562_Human1.36071539
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33723822
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32823316
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30475105
88GATA3_26560356_Chip-Seq_TH2_Human1.30322530
89* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27972274
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.26736849
91* VDR_24787735_ChIP-Seq_THP-1_Human1.24300082
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.22675824
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22550395
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22414238
95MYB_26560356_Chip-Seq_TH2_Human1.21019327
96BCL6_27268052_Chip-Seq_Bcells_Human1.20723131
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18646162
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.17250742
99GATA3_27048872_Chip-Seq_THYMUS_Human1.16964424
100MYB_26560356_Chip-Seq_TH1_Human1.16466234
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14961134
102MAF_26560356_Chip-Seq_TH1_Human1.14762715
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14695236
104* VDR_24763502_ChIP-Seq_THP-1_Human1.14650195
105STAT1_20625510_ChIP-Seq_HELA_Human1.13419659
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13398055
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11727900
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11636916
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11589726
110* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10598847
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.09812400
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09195759
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08203903
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07473681
115* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07448995
116* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06461546
117SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05359190
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04884475
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04551279
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04149898
121SPI1_20517297_ChIP-Seq_HL60_Human1.03384607
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03253255
123UTX_26944678_Chip-Seq_JUKART_Human1.03119574
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03034909
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01745013
126SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01358652
127MAF_26560356_Chip-Seq_TH2_Human1.00753013
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99585800
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99186511
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98490642
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98209190
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96396904
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96382140
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94686572
135LXR_22292898_ChIP-Seq_THP-1_Human0.94314346
136* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94284446
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94213463
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93874413
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93456597
140MYC_18940864_ChIP-ChIP_HL60_Human0.93336005
141MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92682959
142CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92567677
143* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91022139
144* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90497817
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89953854
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89670196
147TCF7_22412390_ChIP-Seq_EML_Mouse0.89242271
148CTCF_26484167_Chip-Seq_Bcells_Mouse0.88899978
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88299908
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88267976
151SA1_27219007_Chip-Seq_Bcells_Human0.88132667
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86755177
153POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86391685
154EGR1_19032775_ChIP-ChIP_M12_Human0.86373111
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86257220
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85993061
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85858858
158P300_27268052_Chip-Seq_Bcells_Human0.83822346
159* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82025531
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81244229
161STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79546538
162CJUN_26792858_Chip-Seq_BT549_Human0.79422141
163CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78658783
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78400924
165BCOR_27268052_Chip-Seq_Bcells_Human0.78081747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.97296315
2MP0002396_abnormal_hematopoietic_system3.96823999
3MP0001545_abnormal_hematopoietic_system3.67642815
4MP0005397_hematopoietic_system_phenotyp3.67642815
5MP0006054_spinal_hemorrhage3.26827593
6MP0009379_abnormal_foot_pigmentation3.18809569
7MP0003656_abnormal_erythrocyte_physiolo3.17414955
8MP0003724_increased_susceptibility_to3.12909712
9MP0008438_abnormal_cutaneous_collagen2.60288891
10MP0004808_abnormal_hematopoietic_stem2.58493926
11MP0001835_abnormal_antigen_presentation2.45615494
12MP0003950_abnormal_plasma_membrane2.45291848
13MP0005174_abnormal_tail_pigmentation2.39709095
14MP0002132_abnormal_respiratory_system2.25855220
15MP0005464_abnormal_platelet_physiology2.19946807
16MP0003191_abnormal_cellular_cholesterol2.17473602
17MP0005671_abnormal_response_to2.14082443
18MP0005075_abnormal_melanosome_morpholog2.12870437
19MP0003763_abnormal_thymus_physiology2.11018302
20MP0006082_CNS_inflammation2.06028043
21MP0000490_abnormal_crypts_of2.03074975
22MP0009785_altered_susceptibility_to2.00181785
23MP0000685_abnormal_immune_system1.97198141
24MP0001853_heart_inflammation1.96051253
25MP0003693_abnormal_embryo_hatching1.93288145
26MP0002398_abnormal_bone_marrow1.92662059
27MP0010094_abnormal_chromosome_stability1.91295502
28MP0000465_gastrointestinal_hemorrhage1.88496519
29MP0002933_joint_inflammation1.83657148
30MP0001542_abnormal_bone_strength1.83548008
31MP0005360_urolithiasis1.78776681
32MP0005503_abnormal_tendon_morphology1.78668477
33MP0006036_abnormal_mitochondrial_physio1.75785935
34MP0008007_abnormal_cellular_replicative1.75026999
35MP0002095_abnormal_skin_pigmentation1.74880678
36MP0003186_abnormal_redox_activity1.71465842
37MP0001873_stomach_inflammation1.68718068
38MP0005025_abnormal_response_to1.63982949
39MP0000689_abnormal_spleen_morphology1.63307637
40MP0003303_peritoneal_inflammation1.60068660
41MP0002166_altered_tumor_susceptibility1.58549039
42MP0002722_abnormal_immune_system1.58191554
43MP0002429_abnormal_blood_cell1.51990912
44MP0001958_emphysema1.51707038
45MP0008058_abnormal_DNA_repair1.51535161
46MP0003806_abnormal_nucleotide_metabolis1.50462064
47MP0000749_muscle_degeneration1.50056348
48MP0009333_abnormal_splenocyte_physiolog1.49895761
49MP0001800_abnormal_humoral_immune1.49573143
50MP0002138_abnormal_hepatobiliary_system1.49452922
51MP0009840_abnormal_foam_cell1.45110160
52MP0003075_altered_response_to1.44666893
53MP0002420_abnormal_adaptive_immunity1.43921499
54MP0004957_abnormal_blastocyst_morpholog1.41830020
55MP0002723_abnormal_immune_serum1.41653369
56MP0000716_abnormal_immune_system1.41590531
57MP0001819_abnormal_immune_cell1.40806894
58MP0002452_abnormal_antigen_presenting1.38678953
59MP0010368_abnormal_lymphatic_system1.35846769
60MP0005058_abnormal_lysosome_morphology1.35575643
61MP0003077_abnormal_cell_cycle1.34894020
62MP0003111_abnormal_nucleus_morphology1.34390206
63MP0005275_abnormal_skin_tensile1.34160521
64MP0003646_muscle_fatigue1.34049856
65MP0000343_altered_response_to1.32926799
66MP0005165_increased_susceptibility_to1.32554657
67MP0005000_abnormal_immune_tolerance1.32224842
68MP0001986_abnormal_taste_sensitivity1.31484307
69MP0008057_abnormal_DNA_replication1.30962096
70MP0002148_abnormal_hypersensitivity_rea1.30526099
71MP0003448_altered_tumor_morphology1.30417939
72MP0004883_abnormal_blood_vessel1.27072664
73MP0001879_abnormal_lymphatic_vessel1.26918342
74MP0010155_abnormal_intestine_physiology1.25961842
75MP0004215_abnormal_myocardial_fiber1.23366334
76MP0002332_abnormal_exercise_endurance1.21632695
77MP0002419_abnormal_innate_immunity1.20091823
78MP0009697_abnormal_copulation1.18843666
79MP0005390_skeleton_phenotype1.18554372
80MP0000703_abnormal_thymus_morphology1.17600837
81MP0004145_abnormal_muscle_electrophysio1.16821567
82MP0005595_abnormal_vascular_smooth1.16734026
83MP0009278_abnormal_bone_marrow1.15813541
84MP0002108_abnormal_muscle_morphology1.14841421
85MP0005164_abnormal_response_to1.14150138
86MP0003943_abnormal_hepatobiliary_system1.14044857
87MP0004036_abnormal_muscle_relaxation1.13905050
88MP0001188_hyperpigmentation1.13627476
89MP0002006_tumorigenesis1.12920215
90MP0003045_fibrosis1.12334490
91MP0000767_abnormal_smooth_muscle1.12069919
92MP0003786_premature_aging1.10902144
93MP0002405_respiratory_system_inflammati1.10692756
94MP0002295_abnormal_pulmonary_circulatio1.10460337
95MP0008469_abnormal_protein_level1.09673839
96MP0005166_decreased_susceptibility_to1.08559718
97MP0003828_pulmonary_edema1.08527752
98MP0000249_abnormal_blood_vessel1.08450501
99MP0006292_abnormal_olfactory_placode1.07369729
100MP0003436_decreased_susceptibility_to1.06249769
101MP0000750_abnormal_muscle_regeneration1.04187730
102MP0000372_irregular_coat_pigmentation1.02583681
103MP0001764_abnormal_homeostasis0.99932068
104MP0005023_abnormal_wound_healing0.99250169
105MP0000015_abnormal_ear_pigmentation0.98897617
106MP0002019_abnormal_tumor_incidence0.98377907
107MP0009384_cardiac_valve_regurgitation0.98192737
108MP0005409_darkened_coat_color0.96942592
109MP0000313_abnormal_cell_death0.94191007
110MP0009764_decreased_sensitivity_to0.90856377
111MP0003567_abnormal_fetal_cardiomyocyte0.90769012
112MP0003279_aneurysm0.90170400
113MP0003866_abnormal_defecation0.89641090
114MP0003705_abnormal_hypodermis_morpholog0.89405966
115MP0000759_abnormal_skeletal_muscle0.89401227
116MP0001845_abnormal_inflammatory_respons0.89297649
117MP0008775_abnormal_heart_ventricle0.89192284
118MP0004272_abnormal_basement_membrane0.89021577
119MP0005084_abnormal_gallbladder_morpholo0.88592622
120MP0003252_abnormal_bile_duct0.88156745
121MP0001790_abnormal_immune_system0.87818159
122MP0005387_immune_system_phenotype0.87818159
123MP0002998_abnormal_bone_remodeling0.87074023
124MP0005636_abnormal_mineral_homeostasis0.87052116
125MP0004510_myositis0.83480514
126MP0002139_abnormal_hepatobiliary_system0.82785228
127MP0000230_abnormal_systemic_arterial0.82135878
128MP0003011_delayed_dark_adaptation0.82055326
129MP0001663_abnormal_digestive_system0.80428618
130MP0000858_altered_metastatic_potential0.79559126
131MP0003300_gastrointestinal_ulcer0.79315228
132MP0005330_cardiomyopathy0.79170989
133MP0002938_white_spotting0.75581318
134MP0005319_abnormal_enzyme/_coenzyme0.69858599
135MP0009763_increased_sensitivity_to0.67762046
136MP0002877_abnormal_melanocyte_morpholog0.65158493
137MP0005167_abnormal_blood-brain_barrier0.64511517
138MP0006035_abnormal_mitochondrial_morpho0.63822311
139MP0000751_myopathy0.63018026
140MP0004084_abnormal_cardiac_muscle0.61485008
141MP0001533_abnormal_skeleton_physiology0.61393375
142MP0002075_abnormal_coat/hair_pigmentati0.60438834
143MP0000598_abnormal_liver_morphology0.59545785

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)7.73788736
2Abnormality of cells of the erythroid lineage (HP:0012130)7.46645647
3Abnormality of the heme biosynthetic pathway (HP:0010472)7.17620517
4Aplastic anemia (HP:0001915)5.22052536
5Reticulocytopenia (HP:0001896)4.94731033
6Petechiae (HP:0000967)4.82372910
7Prolonged bleeding time (HP:0003010)4.70704862
8Pallor (HP:0000980)4.29315746
9Popliteal pterygium (HP:0009756)4.07793312
10Nemaline bodies (HP:0003798)4.00311354
11Thrombocytosis (HP:0001894)3.88765462
12Amniotic constriction ring (HP:0009775)3.81705920
13Abnormality of placental membranes (HP:0011409)3.81705920
14Systemic lupus erythematosus (HP:0002725)3.80701649
15Reduced antithrombin III activity (HP:0001976)3.58195901
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.51767593
17Muscle fiber inclusion bodies (HP:0100299)3.42600212
18Macrocytic anemia (HP:0001972)3.31996743
19Epistaxis (HP:0000421)3.31073954
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.30554037
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.30554037
22Hepatocellular necrosis (HP:0001404)3.22920593
23Type I transferrin isoform profile (HP:0003642)3.21556982
24Abnormal platelet function (HP:0011869)3.20757832
25Impaired platelet aggregation (HP:0003540)3.20757832
26Type 2 muscle fiber atrophy (HP:0003554)3.18649585
27Hepatic necrosis (HP:0002605)3.16511420
28Abnormality of the neuromuscular junction (HP:0003398)3.15563104
29Fatigable weakness (HP:0003473)3.15563104
30Muscle fiber atrophy (HP:0100295)3.08682509
31Type 1 muscle fiber predominance (HP:0003803)2.99790716
32IgM deficiency (HP:0002850)2.98799137
33Increased intramyocellular lipid droplets (HP:0012240)2.98119623
34Aortic aneurysm (HP:0004942)2.91385617
35Increased IgM level (HP:0003496)2.89178745
36Abnormality of reticulocytes (HP:0004312)2.87446613
37Chronic otitis media (HP:0000389)2.85446066
38Increased muscle lipid content (HP:0009058)2.84968332
393-Methylglutaconic aciduria (HP:0003535)2.84264785
40Abnormality of macrophages (HP:0004311)2.79693482
41Mitochondrial inheritance (HP:0001427)2.77675974
42Increased hepatocellular lipid droplets (HP:0006565)2.77193972
43Protrusio acetabuli (HP:0003179)2.75949258
44Aplasia of the musculature (HP:0100854)2.75044544
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73402417
46Lipid accumulation in hepatocytes (HP:0006561)2.71131204
47Pancytopenia (HP:0001876)2.69481175
48Microcytic anemia (HP:0001935)2.69310199
49Elevated erythrocyte sedimentation rate (HP:0003565)2.65687143
50Malignant hyperthermia (HP:0002047)2.64935008
51Increased serum ferritin (HP:0003281)2.64176941
52Gowers sign (HP:0003391)2.57661338
53Fetal akinesia sequence (HP:0001989)2.53686392
54Increased CSF lactate (HP:0002490)2.53057627
55Acanthocytosis (HP:0001927)2.48718118
56Abnormality of glycolipid metabolism (HP:0010969)2.47656858
57Abnormality of liposaccharide metabolism (HP:0010968)2.47656858
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.47656858
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46131973
60Abnormal protein N-linked glycosylation (HP:0012347)2.46131973
61Abnormal protein glycosylation (HP:0012346)2.46131973
62Abnormal glycosylation (HP:0012345)2.46131973
63Microvesicular hepatic steatosis (HP:0001414)2.46052897
64Abnormality of the nasal mucosa (HP:0000433)2.45672151
65Autoimmune hemolytic anemia (HP:0001890)2.45647620
66Exertional dyspnea (HP:0002875)2.45296964
67Round ear (HP:0100830)2.43138181
68Ulnar deviation of the wrist (HP:0003049)2.43082828
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42832126
7011 pairs of ribs (HP:0000878)2.39444434
71Purpura (HP:0000979)2.39166936
72Oral leukoplakia (HP:0002745)2.38748425
73Stomatitis (HP:0010280)2.37838702
74Increased serum lactate (HP:0002151)2.37134218
75Recurrent abscess formation (HP:0002722)2.37128637
76Myelodysplasia (HP:0002863)2.36056789
77Pulmonary infiltrates (HP:0002113)2.35909620
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35653489
79Orchitis (HP:0100796)2.34624225
80Poikilocytosis (HP:0004447)2.34096274
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32009173
82Abnormal mitochondria in muscle tissue (HP:0008316)2.31395616
83Hypergammaglobulinemia (HP:0010702)2.29106718
84Aortic dissection (HP:0002647)2.28513829
85Meningitis (HP:0001287)2.28105393
86Distal lower limb muscle weakness (HP:0009053)2.27347486
87Acute necrotizing encephalopathy (HP:0006965)2.26984821
88Nonprogressive disorder (HP:0003680)2.26777657
89Abnormality of skeletal muscle fiber size (HP:0012084)2.26549056
90Lactic acidosis (HP:0003128)2.24483484
91Hyperbilirubinemia (HP:0002904)2.23159959
92Respiratory difficulties (HP:0002880)2.21749102
93Asymmetric septal hypertrophy (HP:0001670)2.21172329
94Neck muscle weakness (HP:0000467)2.20046169
95Chronic obstructive pulmonary disease (HP:0006510)2.20020647
96Obstructive lung disease (HP:0006536)2.20020647
97Recurrent fungal infections (HP:0002841)2.18558444
98Recurrent cutaneous fungal infections (HP:0011370)2.17709657
99Chronic mucocutaneous candidiasis (HP:0002728)2.17709657
100Distal arthrogryposis (HP:0005684)2.16846194
101Gastrointestinal infarctions (HP:0005244)2.16181511
102Bulbar palsy (HP:0001283)2.16145902
103Generalized aminoaciduria (HP:0002909)2.15639179
104Exercise-induced myalgia (HP:0003738)2.14771778
105Eczematoid dermatitis (HP:0000976)2.14220278
106Spondylolisthesis (HP:0003302)2.13735135
107Birth length less than 3rd percentile (HP:0003561)2.12673800
108Hemoptysis (HP:0002105)2.12512311
109Panhypogammaglobulinemia (HP:0003139)2.12010913
110Abnormality of T cell physiology (HP:0011840)2.11515871
111Progressive muscle weakness (HP:0003323)2.08697335
112Renal Fanconi syndrome (HP:0001994)2.08600885
113Complement deficiency (HP:0004431)2.08238285
114Microretrognathia (HP:0000308)2.07617076
115Exercise intolerance (HP:0003546)2.07295968
116Vasculitis (HP:0002633)2.07109758
117Chest pain (HP:0100749)2.06896499
118Weak cry (HP:0001612)2.06656300
119Abnormality of iron homeostasis (HP:0011031)2.05778301
120Abnormality of T cell number (HP:0011839)2.02951636
121Increased variability in muscle fiber diameter (HP:0003557)2.02544165
122Joint stiffness (HP:0001387)2.02030017
123Neutropenia (HP:0001875)2.01159601
124Peritonitis (HP:0002586)2.01132216
125Optic neuritis (HP:0100653)1.99886996
126Retrobulbar optic neuritis (HP:0100654)1.99886996
127Abnormal pupillary function (HP:0007686)1.99390206
128Eosinophilia (HP:0001880)1.98766741
129Vascular tortuosity (HP:0004948)1.96005425
130Dysostosis multiplex (HP:0000943)1.95369494
131Abnormality of T cells (HP:0002843)1.95137117
132Hypoplasia of the thymus (HP:0000778)1.94529059
133Polycythemia (HP:0001901)1.94295055
134Granulocytopenia (HP:0001913)1.92315169
135Hyperlipoproteinemia (HP:0010980)1.91324949
136Encephalitis (HP:0002383)1.91255078
137Ragged-red muscle fibers (HP:0003200)1.91099306
138Agammaglobulinemia (HP:0004432)1.91017452
139Recurrent bacterial skin infections (HP:0005406)1.90850601
140Recurrent bronchitis (HP:0002837)1.88896589
141Nasal polyposis (HP:0100582)1.88810019
142Hepatosplenomegaly (HP:0001433)1.88415290
143Hematochezia (HP:0002573)1.87990678
144T lymphocytopenia (HP:0005403)1.87577994
145Severe visual impairment (HP:0001141)1.86111890
146Muscle fiber splitting (HP:0003555)1.85874177
147Hyporeflexia of lower limbs (HP:0002600)1.85500404
148Abnormal delayed hypersensitivity skin test (HP:0002963)1.84790835
149Acute myeloid leukemia (HP:0004808)1.83928170
150Abnormality of complement system (HP:0005339)1.83491675
151Recurrent skin infections (HP:0001581)1.82707169
152Respiratory insufficiency due to muscle weakness (HP:0002747)1.82347538
153Abnormality of B cell number (HP:0010975)1.82043875
154Rhabdomyolysis (HP:0003201)1.81164687
155IgG deficiency (HP:0004315)1.79978638
156Hypoproteinemia (HP:0003075)1.79298670
157Abnormality of alanine metabolism (HP:0010916)1.79194459
158Hyperalaninemia (HP:0003348)1.79194459
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79194459
160Recurrent gram-negative bacterial infections (HP:0005420)1.78252989
161Acute encephalopathy (HP:0006846)1.77365594
162Chronic diarrhea (HP:0002028)1.77284302
163Premature rupture of membranes (HP:0001788)1.76803366
164Recurrent viral infections (HP:0004429)1.74981687
165Migraine (HP:0002076)1.74971683
166Esophageal neoplasm (HP:0100751)1.74611097
167Neoplasm of head and neck (HP:0012288)1.74611097
168Patchy hypopigmentation of hair (HP:0011365)1.73854805
169Albinism (HP:0001022)1.72079458
170Short middle phalanx of the 5th finger (HP:0004220)1.71436052
171Reticulocytosis (HP:0001923)1.70849126
172Easy fatigability (HP:0003388)1.70560767
173Abnormality of transition element cation homeostasis (HP:0011030)1.69544992
174Spontaneous hematomas (HP:0007420)1.69459898
175Gingival bleeding (HP:0000225)1.69448780
176Abnormal spermatogenesis (HP:0008669)1.69221729
177Lymphoma (HP:0002665)1.68767041
178Acute lymphatic leukemia (HP:0006721)1.68740910
179Myositis (HP:0100614)1.67721960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.10127909
2NME23.84483391
3MUSK3.12053724
4TIE12.81053234
5KDR2.54561671
6PIM22.50526432
7MAP4K12.34128565
8TGFBR12.25254246
9KIT2.23750475
10WEE12.23227296
11TNIK2.22370403
12ACVR1B2.13626342
13TGFBR22.12316748
14TEC2.07427695
15LIMK12.07207971
16VRK11.92874872
17CDK191.90079679
18FES1.73811602
19MAP2K31.70875064
20CDK81.67149164
21BTK1.64778080
22DYRK31.63987271
23TESK21.62876976
24EIF2AK11.58104739
25VRK21.56298219
26RIPK41.52862734
27MKNK11.49823174
28TXK1.46456393
29MAP3K121.43293974
30MYLK1.41997183
31TBK11.37192360
32MAPKAPK51.35871589
33TESK11.32500474
34MOS1.30920713
35CSK1.29465813
36PRKG21.27220430
37MATK1.25741741
38IKBKE1.25549122
39EEF2K1.24103388
40RPS6KB21.23951668
41JAK31.22853833
42BCKDK1.19919840
43MKNK21.19087197
44PTK2B1.18788006
45JAK11.15389438
46ITK1.14910196
47FLT31.09164531
48ZAP701.08411099
49SCYL21.07464911
50TLK11.07147991
51CDK71.04548665
52LRRK21.03130079
53PIM11.02772730
54IKBKB1.01552261
55SRPK10.99950887
56IRAK40.99612651
57BRSK20.99600716
58EIF2AK30.97345868
59ABL20.97034717
60ADRBK20.95323839
61HCK0.94622177
62CDC70.94128550
63GRK60.90760669
64TYK20.87795113
65ATR0.84741210
66NEK20.84530348
67EPHB20.82794186
68DDR20.82028989
69EIF2AK20.82000934
70PRKD20.81765772
71RPS6KA40.81701900
72MAPKAPK30.81081472
73ROCK10.81070028
74DAPK30.80022498
75ILK0.79802379
76SYK0.79280979
77CAMK10.79121829
78BUB10.79085384
79BLK0.78631215
80MAP3K110.77921980
81CSF1R0.77532816
82PIK3CG0.77418571
83CCNB10.75991823
84ADRBK10.75815936
85MAP3K70.74801009
86LYN0.74683588
87PINK10.72964789
88OBSCN0.72494999
89MAPK120.72386825
90GRK50.72077825
91NUAK10.70478495
92PRKCQ0.70398953
93TAOK30.70134530
94TNK20.64270279
95GRK10.64234870
96PKN20.64189289
97ARAF0.63746710
98CDK40.63223525
99MAP3K60.62907198
100AURKB0.61355114
101ZAK0.59788213
102MAPK40.59582312
103STK240.58345332
104MAPK70.58221050
105EPHB10.57346629
106ABL10.56811932
107NLK0.56809359
108MAP4K20.55809684
109PASK0.55563648
110BMPR20.54829177
111MST40.54102836
112IRAK30.53130793
113MAP3K140.51203297
114IGF1R0.49738139
115MAPK110.48788316
116PAK40.47772518
117MAP3K130.46824933
118DAPK10.46274984
119RPS6KA60.45086494
120PRKD10.44510891
121TSSK60.44316098
122SIK30.43316504
123NEK90.43232532
124MAP3K30.43119707
125STK40.42637547
126FER0.41573924
127TTN0.41335167
128CSNK2A10.41080447
129MAP2K60.40881243
130ERN10.40836209
131GRK70.40554756
132LCK0.40321425
133PRKCD0.40202050
134STK100.39911687
135NME10.39779120
136INSRR0.39507036
137RPS6KA50.39405066
138TRPM70.39054432
139CSNK2A20.39002913
140TAOK20.37618643
141JAK20.37315533
142PHKG10.36336288
143PHKG20.36336288
144FGR0.35459072
145INSR0.34659200
146CDC42BPA0.34531918
147MAPKAPK20.31415178
148ROCK20.31381201

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.83278870
2DNA replication_Homo sapiens_hsa030304.80340542
3Graft-versus-host disease_Homo sapiens_hsa053323.54573186
4Autoimmune thyroid disease_Homo sapiens_hsa053203.53584484
5Staphylococcus aureus infection_Homo sapiens_hsa051503.22912561
6Mismatch repair_Homo sapiens_hsa034303.18296305
7Base excision repair_Homo sapiens_hsa034102.76251760
8Type I diabetes mellitus_Homo sapiens_hsa049402.71356632
9Homologous recombination_Homo sapiens_hsa034402.71132688
10RNA polymerase_Homo sapiens_hsa030202.65540902
11Pyrimidine metabolism_Homo sapiens_hsa002402.61326895
12Nucleotide excision repair_Homo sapiens_hsa034202.37486708
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26689859
14Proteasome_Homo sapiens_hsa030502.24133131
15Spliceosome_Homo sapiens_hsa030402.20627364
16Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.05632704
17Rheumatoid arthritis_Homo sapiens_hsa053231.91139744
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84505734
19Parkinsons disease_Homo sapiens_hsa050121.72046866
20Sulfur relay system_Homo sapiens_hsa041221.71119353
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67794726
22Protein export_Homo sapiens_hsa030601.66939256
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65833146
24Fanconi anemia pathway_Homo sapiens_hsa034601.58744622
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.58093905
26RNA degradation_Homo sapiens_hsa030181.57219965
27Folate biosynthesis_Homo sapiens_hsa007901.55967446
28Purine metabolism_Homo sapiens_hsa002301.53865109
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51601798
30Complement and coagulation cascades_Homo sapiens_hsa046101.49230024
31Non-homologous end-joining_Homo sapiens_hsa034501.46426973
32Hematopoietic cell lineage_Homo sapiens_hsa046401.46217670
33Primary immunodeficiency_Homo sapiens_hsa053401.44989160
34Cell cycle_Homo sapiens_hsa041101.29606452
35Caffeine metabolism_Homo sapiens_hsa002321.29425330
36Basal transcription factors_Homo sapiens_hsa030221.27697450
37Herpes simplex infection_Homo sapiens_hsa051681.26731614
38Tuberculosis_Homo sapiens_hsa051521.24073513
39Oxidative phosphorylation_Homo sapiens_hsa001901.21134845
40Sulfur metabolism_Homo sapiens_hsa009201.20333931
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16568243
42RNA transport_Homo sapiens_hsa030131.15512286
43Huntingtons disease_Homo sapiens_hsa050161.14610207
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12996715
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12290812
46Phagosome_Homo sapiens_hsa041451.11220032
47Measles_Homo sapiens_hsa051621.08808983
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07889964
49p53 signaling pathway_Homo sapiens_hsa041151.02908893
50Pentose phosphate pathway_Homo sapiens_hsa000301.01264721
51One carbon pool by folate_Homo sapiens_hsa006701.01158586
52Lysosome_Homo sapiens_hsa041420.97603617
53Alzheimers disease_Homo sapiens_hsa050100.92484513
54Antigen processing and presentation_Homo sapiens_hsa046120.91571684
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89311481
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.88164741
57Platelet activation_Homo sapiens_hsa046110.87812756
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87094843
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.86763401
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86160944
61African trypanosomiasis_Homo sapiens_hsa051430.85935963
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83343190
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81327225
64Galactose metabolism_Homo sapiens_hsa000520.81261260
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80008914
66N-Glycan biosynthesis_Homo sapiens_hsa005100.78912103
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.78450353
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76032193
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75827040
70* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75432531
71Systemic lupus erythematosus_Homo sapiens_hsa053220.75432105
72Linoleic acid metabolism_Homo sapiens_hsa005910.73306208
73Leishmaniasis_Homo sapiens_hsa051400.73150854
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.72998570
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71124138
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.66913501
77Chemokine signaling pathway_Homo sapiens_hsa040620.66478409
78Legionellosis_Homo sapiens_hsa051340.64647659
79Acute myeloid leukemia_Homo sapiens_hsa052210.64405334
80Salmonella infection_Homo sapiens_hsa051320.64103342
81Tryptophan metabolism_Homo sapiens_hsa003800.63840851
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60355831
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59335811
84Dilated cardiomyopathy_Homo sapiens_hsa054140.58743515
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58110603
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57948193
87ECM-receptor interaction_Homo sapiens_hsa045120.57940206
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.57816499
89B cell receptor signaling pathway_Homo sapiens_hsa046620.57616209
90Selenocompound metabolism_Homo sapiens_hsa004500.54803220
91Malaria_Homo sapiens_hsa051440.54602285
92Epstein-Barr virus infection_Homo sapiens_hsa051690.53592117
93Fatty acid elongation_Homo sapiens_hsa000620.52477219
94Hepatitis B_Homo sapiens_hsa051610.52369442
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.51916028
96Other glycan degradation_Homo sapiens_hsa005110.51130975
97Asthma_Homo sapiens_hsa053100.49613631
98Amoebiasis_Homo sapiens_hsa051460.49369662
99Glutathione metabolism_Homo sapiens_hsa004800.48755891
100Apoptosis_Homo sapiens_hsa042100.48445428
101TNF signaling pathway_Homo sapiens_hsa046680.47874764
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46857619
103Metabolic pathways_Homo sapiens_hsa011000.46834932
104T cell receptor signaling pathway_Homo sapiens_hsa046600.44729236
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.44463591
106Thyroid cancer_Homo sapiens_hsa052160.43796410
107Focal adhesion_Homo sapiens_hsa045100.43567386
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43483826
109Arachidonic acid metabolism_Homo sapiens_hsa005900.42972975
110Small cell lung cancer_Homo sapiens_hsa052220.42488181
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42247612
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41989618
113Shigellosis_Homo sapiens_hsa051310.41142668
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40030940
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39035393
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.38403809
117Influenza A_Homo sapiens_hsa051640.37959133
118Cardiac muscle contraction_Homo sapiens_hsa042600.37377700
119Peroxisome_Homo sapiens_hsa041460.37367094
120Allograft rejection_Homo sapiens_hsa053300.36641120
121ABC transporters_Homo sapiens_hsa020100.36485121
122Viral carcinogenesis_Homo sapiens_hsa052030.36167250
123Retinol metabolism_Homo sapiens_hsa008300.36007363
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35966418
125HTLV-I infection_Homo sapiens_hsa051660.34970717
126PPAR signaling pathway_Homo sapiens_hsa033200.33684001
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33582844
128Endocytosis_Homo sapiens_hsa041440.33112437
129Pertussis_Homo sapiens_hsa051330.30853118
130Propanoate metabolism_Homo sapiens_hsa006400.29550258
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.28300815
132Regulation of autophagy_Homo sapiens_hsa041400.27156990
133Toxoplasmosis_Homo sapiens_hsa051450.26929241
134Fatty acid degradation_Homo sapiens_hsa000710.26474633
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22612028
136Carbon metabolism_Homo sapiens_hsa012000.22278920
137Chronic myeloid leukemia_Homo sapiens_hsa052200.20133860
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19410014
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19324143
140Osteoclast differentiation_Homo sapiens_hsa043800.19128472
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15539951
142Chemical carcinogenesis_Homo sapiens_hsa052040.15165824
143Viral myocarditis_Homo sapiens_hsa054160.14241298

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