VAMP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.19948934
2fatty acid elongation (GO:0030497)4.86668827
3* neutrophil activation involved in immune response (GO:0002283)4.73190795
4protein neddylation (GO:0045116)4.70429372
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.25173329
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.19535541
7cullin deneddylation (GO:0010388)4.12163238
8presynaptic membrane assembly (GO:0097105)4.07308280
9protein complex biogenesis (GO:0070271)3.94522860
10ATP synthesis coupled proton transport (GO:0015986)3.92017902
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92017902
12NADH dehydrogenase complex assembly (GO:0010257)3.90645453
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90645453
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.90645453
15nucleotide transmembrane transport (GO:1901679)3.84582207
16protein deneddylation (GO:0000338)3.83806913
17presynaptic membrane organization (GO:0097090)3.79616743
18ER overload response (GO:0006983)3.71649081
19chaperone-mediated protein transport (GO:0072321)3.71554461
20thrombin receptor signaling pathway (GO:0070493)3.65348785
21megakaryocyte development (GO:0035855)3.62590884
22respiratory chain complex IV assembly (GO:0008535)3.60697320
23respiratory electron transport chain (GO:0022904)3.50718943
24electron transport chain (GO:0022900)3.43986013
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.41727104
26L-phenylalanine catabolic process (GO:0006559)3.41727104
27mitochondrial respiratory chain complex assembly (GO:0033108)3.38431690
28aldehyde catabolic process (GO:0046185)3.37583398
29ATP hydrolysis coupled proton transport (GO:0015991)3.32261605
30energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.32261605
31negative regulation of protein localization to plasma membrane (GO:1903077)3.30449228
32transferrin transport (GO:0033572)3.29192109
33hepatocyte apoptotic process (GO:0097284)3.29017099
34mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.28634158
35cholesterol biosynthetic process (GO:0006695)3.25646475
36regulation of early endosome to late endosome transport (GO:2000641)3.23600749
37long-chain fatty acid biosynthetic process (GO:0042759)3.17001668
38central nervous system myelination (GO:0022010)3.16783432
39axon ensheathment in central nervous system (GO:0032291)3.16783432
40negative regulation of thymocyte apoptotic process (GO:0070244)3.16282681
41cytochrome complex assembly (GO:0017004)3.14229455
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12542674
43peptide catabolic process (GO:0043171)3.11942063
44protein maturation by protein folding (GO:0022417)3.11806507
45oxygen transport (GO:0015671)3.10531453
46trivalent inorganic cation transport (GO:0072512)3.09833948
47ferric iron transport (GO:0015682)3.09833948
48positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.08846875
49phagosome maturation (GO:0090382)3.03160374
50L-phenylalanine metabolic process (GO:0006558)3.03013592
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03013592
52platelet aggregation (GO:0070527)3.01379858
53nuclear pore complex assembly (GO:0051292)3.01109406
54regulation of integrin-mediated signaling pathway (GO:2001044)3.01089590
55mannosylation (GO:0097502)2.99048895
56negative regulation of neurotransmitter transport (GO:0051589)2.96245085
57dopamine transport (GO:0015872)2.95028000
58protoporphyrinogen IX metabolic process (GO:0046501)2.93136431
59regulation of platelet aggregation (GO:0090330)2.92344335
60gonadal mesoderm development (GO:0007506)2.88906865
61sterol biosynthetic process (GO:0016126)2.88749248
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88278002
63protein localization to cilium (GO:0061512)2.87109198
64positive regulation of protein homodimerization activity (GO:0090073)2.86862909
65negative regulation of dendrite morphogenesis (GO:0050774)2.86009379
66neuronal action potential propagation (GO:0019227)2.85383959
67pH reduction (GO:0045851)2.84047484
68peroxisome fission (GO:0016559)2.81478117
69negative regulation of homotypic cell-cell adhesion (GO:0034111)2.80865001
70definitive hemopoiesis (GO:0060216)2.79211253
71mitotic G2 DNA damage checkpoint (GO:0007095)2.76980101
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.75623321
73response to redox state (GO:0051775)2.75190430
74neuron cell-cell adhesion (GO:0007158)2.73858095
75positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73608322
76long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.73372216
77positive regulation of mitochondrial fission (GO:0090141)2.72652318
78intracellular pH reduction (GO:0051452)2.69394078
79substantia nigra development (GO:0021762)2.68951263
80succinate metabolic process (GO:0006105)2.67499444
81protein localization to endosome (GO:0036010)2.67186470
82L-methionine salvage (GO:0071267)2.66171792
83L-methionine biosynthetic process (GO:0071265)2.66171792
84amino acid salvage (GO:0043102)2.66171792
85nucleotide transport (GO:0006862)2.65670132
86cofactor catabolic process (GO:0051187)2.65510497
87* phagocytosis, engulfment (GO:0006911)2.65170852
88positive regulation of granulocyte differentiation (GO:0030854)2.65072466
89negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.63308967
90regulation of integrin activation (GO:0033623)2.62489673
91positive regulation of macrophage differentiation (GO:0045651)2.61942558
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60596626
93positive regulation of mast cell activation (GO:0033005)2.60507095
94deoxyribose phosphate biosynthetic process (GO:0046385)2.60311788
952-deoxyribonucleotide biosynthetic process (GO:0009265)2.60311788
96viral protein processing (GO:0019082)2.59243721
97response to peptidoglycan (GO:0032494)2.58239316
98negative regulation of neurotransmitter secretion (GO:0046929)2.57240531
99nuclear pore organization (GO:0006999)2.55575472
100protein localization to microtubule (GO:0035372)2.55432325
101dopamine biosynthetic process (GO:0042416)2.54953365
102copper ion homeostasis (GO:0055070)2.54781704
103regulation of platelet activation (GO:0010543)2.54376456
104synaptic vesicle exocytosis (GO:0016079)2.54076647
105cellular response to thyroid hormone stimulus (GO:0097067)2.53910181
106protein-cofactor linkage (GO:0018065)2.53669736
107positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53546316
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.53305607
109fatty-acyl-CoA metabolic process (GO:0035337)2.52635672
110regulation of Golgi to plasma membrane protein transport (GO:0042996)2.52526843
111positive regulation of B cell differentiation (GO:0045579)2.52413018
112protein localization to chromosome, centromeric region (GO:0071459)2.51350419
113mRNA modification (GO:0016556)2.50165032
114hydrogen ion transmembrane transport (GO:1902600)2.48714638
115cellular copper ion homeostasis (GO:0006878)2.47698175
116gas transport (GO:0015669)2.47350854
117proton transport (GO:0015992)2.47084613
118G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.46876859
119inositol phosphate catabolic process (GO:0071545)2.46684982
120regulation of oxidative phosphorylation (GO:0002082)2.46471324
121regulation of cellular amino acid metabolic process (GO:0006521)2.46240984
122regulation of dopamine metabolic process (GO:0042053)2.46204259
123regulation of catecholamine metabolic process (GO:0042069)2.46204259
124positive regulation of cellular amine metabolic process (GO:0033240)2.45865401
125ribosome assembly (GO:0042255)2.43745206
126Golgi transport vesicle coating (GO:0048200)2.43041240
127COPI coating of Golgi vesicle (GO:0048205)2.43041240
128proteasome assembly (GO:0043248)2.42730683
129formation of translation preinitiation complex (GO:0001731)2.42491708
130erythrocyte maturation (GO:0043249)2.42207905
131hydrogen transport (GO:0006818)2.41794767
132myeloid cell development (GO:0061515)2.41189524
133regulation of mast cell degranulation (GO:0043304)2.41077387
134regulation of T-helper 1 cell differentiation (GO:0045625)2.40408522
135neurotransmitter uptake (GO:0001504)2.39548362
136mitotic G2/M transition checkpoint (GO:0044818)2.39276942
137negative regulation of T-helper cell differentiation (GO:0045623)2.38986453
138negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.38986453
139fatty-acyl-CoA biosynthetic process (GO:0046949)2.38724866
140pore complex assembly (GO:0046931)2.38632624
141* membrane invagination (GO:0010324)2.37860136
142coenzyme catabolic process (GO:0009109)2.36952362
143N-acetylglucosamine metabolic process (GO:0006044)2.36741821
144response to thyroid hormone (GO:0097066)2.36697789
145phospholipid scrambling (GO:0017121)2.36626427
146* neutrophil activation (GO:0042119)2.36088355
147isoprenoid biosynthetic process (GO:0008299)2.34413218
148nucleoside salvage (GO:0043174)2.34046124
149regulation of homotypic cell-cell adhesion (GO:0034110)2.33812030
150* granulocyte activation (GO:0036230)2.33663517
151cellular response to arsenic-containing substance (GO:0071243)2.33481717
152actin nucleation (GO:0045010)2.32673641
153positive regulation of amino acid transport (GO:0051957)2.32601451
154aromatic amino acid family catabolic process (GO:0009074)2.32412016
155histamine secretion (GO:0001821)2.32035688
156endothelium development (GO:0003158)2.31623449
157negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.31591143
158deoxyribonucleotide biosynthetic process (GO:0009263)2.31579939
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.31306421
160negative regulation of JUN kinase activity (GO:0043508)2.30694253
161B cell mediated immunity (GO:0019724)2.29602144
162postsynaptic membrane organization (GO:0001941)2.29105043
163negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.28728140
164vesicle coating (GO:0006901)2.28473830
165positive regulation of T cell cytokine production (GO:0002726)2.28363960
166protein localization to lysosome (GO:0061462)2.28031702
167protein localization to vacuole (GO:0072665)2.28031702
168purine-containing compound salvage (GO:0043101)2.27673913
169platelet degranulation (GO:0002576)2.27495697
170regulation of alpha-beta T cell proliferation (GO:0046640)2.26867142
171deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.26223343
172negative regulation of T cell apoptotic process (GO:0070233)2.26089744
173negative regulation of erythrocyte differentiation (GO:0045647)2.25274877
174poly(A)+ mRNA export from nucleus (GO:0016973)2.24636743
175regulation of RIG-I signaling pathway (GO:0039535)2.23797659
176regulation of mast cell activation involved in immune response (GO:0033006)2.23293660
177adenosine receptor signaling pathway (GO:0001973)2.23283789
178fibril organization (GO:0097435)2.22867496
179protein localization to kinetochore (GO:0034501)2.22745670
180positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.22102463
181positive regulation of leukocyte degranulation (GO:0043302)2.21864759
182leukocyte tethering or rolling (GO:0050901)2.21863315
183positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.21586623
184angiogenesis involved in wound healing (GO:0060055)2.19793607
185regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19063671
186positive regulation of gamma-delta T cell activation (GO:0046645)2.17057510
187pinocytosis (GO:0006907)2.15578708
188purine nucleotide salvage (GO:0032261)2.14811592
189pyrimidine nucleoside salvage (GO:0043097)2.14246476
190pyrimidine-containing compound salvage (GO:0008655)2.14246476
191extracellular fibril organization (GO:0043206)2.14238305
192regulation of defense response to virus by virus (GO:0050690)2.13217972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.83163582
2TAF15_26573619_Chip-Seq_HEK293_Human3.69891065
3GBX2_23144817_ChIP-Seq_PC3_Human3.65439861
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.10153295
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05356719
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01898328
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.95744529
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90033782
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82021236
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75538749
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72449064
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.71195048
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67579340
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59662119
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.59589820
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57898609
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54307063
18VDR_22108803_ChIP-Seq_LS180_Human2.49948020
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.42510718
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42127345
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27374922
22IGF1R_20145208_ChIP-Seq_DFB_Human2.24327710
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19742093
24PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.15863604
25IRF8_22096565_ChIP-ChIP_GC-B_Human2.11252733
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10256527
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07437981
28SCL_19346495_ChIP-Seq_HPC-7_Human2.05798827
29SPI1_23547873_ChIP-Seq_NB4_Human1.99674061
30P300_19829295_ChIP-Seq_ESCs_Human1.99536364
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94415271
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93091764
33TFEB_21752829_ChIP-Seq_HELA_Human1.91867633
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.90332915
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87465091
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87008350
37FUS_26573619_Chip-Seq_HEK293_Human1.86499915
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85450689
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.84672602
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83158659
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81813958
42AR_21909140_ChIP-Seq_LNCAP_Human1.80918070
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79540404
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77271195
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76230521
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74064602
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72232728
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.70758794
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69253059
50GATA1_19941826_ChIP-Seq_K562_Human1.68835568
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68328472
52ER_23166858_ChIP-Seq_MCF-7_Human1.68251020
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67093734
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65564116
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65487388
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.63945155
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.61213553
58MYB_26560356_Chip-Seq_TH2_Human1.61112830
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60564467
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60442019
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.59878153
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.59543031
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58286213
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57578800
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56749747
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.56367094
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55981896
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55007937
69GATA2_19941826_ChIP-Seq_K562_Human1.52212741
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51890678
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51413591
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51284403
73HTT_18923047_ChIP-ChIP_STHdh_Human1.50997932
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49684471
75SPI1_23127762_ChIP-Seq_K562_Human1.49644841
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49316657
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48680989
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48028496
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48003803
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47330118
81ELK1_19687146_ChIP-ChIP_HELA_Human1.46537699
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46499473
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.45501880
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45074179
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44983233
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44457410
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.43921389
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43352078
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42753743
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42753743
91IRF1_19129219_ChIP-ChIP_H3396_Human1.40447720
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40360822
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40249448
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39739885
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.39610577
96DCP1A_22483619_ChIP-Seq_HELA_Human1.39459367
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39290719
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.39121319
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37093245
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36667468
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35763195
102SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34418690
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34284377
104SMAD4_21799915_ChIP-Seq_A2780_Human1.32840653
105EWS_26573619_Chip-Seq_HEK293_Human1.32499386
106MYB_26560356_Chip-Seq_TH1_Human1.31316587
107P53_22387025_ChIP-Seq_ESCs_Mouse1.29805619
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29785735
109REST_19997604_ChIP-ChIP_NEURONS_Mouse1.29491079
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29178957
111* NCOR1_26117541_ChIP-Seq_K562_Human1.29049982
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.28996395
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27583829
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25908712
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25805155
116NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25704900
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25348582
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24579194
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24496196
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.23766413
121JUN_21703547_ChIP-Seq_K562_Human1.23400934
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22397083
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.21049897
124SOX2_19829295_ChIP-Seq_ESCs_Human1.19842846
125NANOG_19829295_ChIP-Seq_ESCs_Human1.19842846
126PU_27001747_Chip-Seq_BMDM_Mouse1.19348555
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.19043627
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19038950
129CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18761143
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16801813
131WT1_19549856_ChIP-ChIP_CCG9911_Human1.16682946
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16394190
133GATA1_22025678_ChIP-Seq_K562_Human1.15718422
134P300_18555785_Chip-Seq_ESCs_Mouse1.15455991
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15305967
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15141402
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14944139
138MYC_18555785_ChIP-Seq_MESCs_Mouse1.14341816
139RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13460185
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13379903
141RNF2_27304074_Chip-Seq_NSC_Mouse1.12915365
142SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12819552
143CLOCK_20551151_ChIP-Seq_293T_Human1.12601281
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12155505
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12026125
146SOX2_18555785_Chip-Seq_ESCs_Mouse1.12018871
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11815804
148E2F1_18555785_Chip-Seq_ESCs_Mouse1.10236119
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08414897
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08142055
151RUNX_20019798_ChIP-Seq_JUKART_Human1.07942696
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07660796
153MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07301509
154SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06849353
155FOXP3_21729870_ChIP-Seq_TREG_Human1.06634829
156NMYC_18555785_Chip-Seq_ESCs_Mouse1.06613520
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06135933
158EED_16625203_ChIP-ChIP_MESCs_Mouse1.05883183
159SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05251124
160SALL4_22934838_ChIP-ChIP_CD34+_Human1.04725700
161VDR_23849224_ChIP-Seq_CD4+_Human1.03867929
162EZH2_27294783_Chip-Seq_NPCs_Mouse1.03707245
163SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03689924
164SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03689924
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03350276
166STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02566571
167MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01969043
168HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01131729
169SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00807181
170GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00299815
171AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00267082
172REST_21632747_ChIP-Seq_MESCs_Mouse1.00198902
173E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98027307
174AR_25329375_ChIP-Seq_VCAP_Human0.97889438
175KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97757181
176CBX2_27304074_Chip-Seq_ESCs_Mouse0.97016307
177PRDM14_20953172_ChIP-Seq_ESCs_Human0.96298925
178GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96093610
179MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95917267
180KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95789750
181JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95775337
182KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95735528
183IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95670541
184SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95419126
185FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93980256
186SMAD_19615063_ChIP-ChIP_OVARY_Human0.93330396
187ETS1_20019798_ChIP-Seq_JURKAT_Human0.93166970
188STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93127138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.69616937
2MP0003880_abnormal_central_pattern3.94730423
3MP0002877_abnormal_melanocyte_morpholog3.39888540
4MP0003195_calcinosis3.06660571
5MP0010386_abnormal_urinary_bladder2.85067024
6MP0002139_abnormal_hepatobiliary_system2.73148815
7MP0001986_abnormal_taste_sensitivity2.72835083
8MP0006276_abnormal_autonomic_nervous2.68612563
9MP0008004_abnormal_stomach_pH2.66991505
10MP0008875_abnormal_xenobiotic_pharmacok2.55167404
11MP0002876_abnormal_thyroid_physiology2.53251482
12MP0001835_abnormal_antigen_presentation2.53210851
13MP0003806_abnormal_nucleotide_metabolis2.52356436
14MP0009697_abnormal_copulation2.50717046
15MP0000465_gastrointestinal_hemorrhage2.50497547
16MP0001529_abnormal_vocalization2.44519775
17MP0001905_abnormal_dopamine_level2.43543326
18MP0004270_analgesia2.39885196
19MP0002735_abnormal_chemical_nociception2.38486975
20MP0002736_abnormal_nociception_after2.25692636
21MP0001968_abnormal_touch/_nociception2.19173510
22MP0002272_abnormal_nervous_system2.13711984
23MP0002734_abnormal_mechanical_nocicepti2.09912106
24MP0010352_gastrointestinal_tract_polyps2.08178108
25MP0005379_endocrine/exocrine_gland_phen2.07477884
26MP0003183_abnormal_peptide_metabolism2.06057198
27MP0001188_hyperpigmentation2.03674995
28MP0004043_abnormal_pH_regulation1.91482541
29MP0009745_abnormal_behavioral_response1.91441083
30MP0002064_seizures1.88644728
31MP0003566_abnormal_cell_adhesion1.88045432
32MP0003191_abnormal_cellular_cholesterol1.84921415
33MP0005451_abnormal_body_composition1.83530049
34MP0008260_abnormal_autophagy1.81211212
35MP0005646_abnormal_pituitary_gland1.79633681
36MP0005408_hypopigmentation1.75889599
37MP0002148_abnormal_hypersensitivity_rea1.75105786
38MP0000920_abnormal_myelination1.73635441
39MP0005085_abnormal_gallbladder_physiolo1.72866879
40MP0000343_altered_response_to1.72586812
41MP0005365_abnormal_bile_salt1.72445678
42MP0005084_abnormal_gallbladder_morpholo1.70370917
43MP0000013_abnormal_adipose_tissue1.69471207
44MP0003436_decreased_susceptibility_to1.68110666
45MP0010155_abnormal_intestine_physiology1.67932251
46MP0009785_altered_susceptibility_to1.64325438
47MP0003300_gastrointestinal_ulcer1.61121649
48MP0002572_abnormal_emotion/affect_behav1.60584972
49MP0004957_abnormal_blastocyst_morpholog1.59609095
50MP0009780_abnormal_chondrocyte_physiolo1.59520871
51MP0004142_abnormal_muscle_tone1.58384577
52MP0003635_abnormal_synaptic_transmissio1.57063360
53MP0005000_abnormal_immune_tolerance1.56539231
54MP0003828_pulmonary_edema1.56380903
55MP0003186_abnormal_redox_activity1.55119262
56MP0003718_maternal_effect1.53517872
57MP0009046_muscle_twitch1.51819270
58MP0001970_abnormal_pain_threshold1.51090639
59MP0002398_abnormal_bone_marrow1.47961561
60MP0005671_abnormal_response_to1.47554354
61MP0001501_abnormal_sleep_pattern1.46454242
62MP0002063_abnormal_learning/memory/cond1.43854490
63MP0002419_abnormal_innate_immunity1.43708826
64MP0005171_absent_coat_pigmentation1.40373047
65MP0002166_altered_tumor_susceptibility1.39186537
66MP0009333_abnormal_splenocyte_physiolog1.39050927
67MP0010234_abnormal_vibrissa_follicle1.38935628
68MP0002837_dystrophic_cardiac_calcinosis1.37531190
69MP0000858_altered_metastatic_potential1.37222172
70MP0001984_abnormal_olfaction1.37189307
71MP0003763_abnormal_thymus_physiology1.36947802
72MP0000372_irregular_coat_pigmentation1.35861774
73MP0003879_abnormal_hair_cell1.34938856
74MP0006036_abnormal_mitochondrial_physio1.34052868
75MP0003303_peritoneal_inflammation1.33581641
76MP0002452_abnormal_antigen_presenting1.32933620
77MP0001764_abnormal_homeostasis1.32280170
78MP0002067_abnormal_sensory_capabilities1.32161108
79MP0002733_abnormal_thermal_nociception1.31892143
80MP0003448_altered_tumor_morphology1.29890124
81MP0010094_abnormal_chromosome_stability1.26745425
82MP0002396_abnormal_hematopoietic_system1.26271627
83MP0004947_skin_inflammation1.25693740
84MP0001853_heart_inflammation1.24997246
85MP0009379_abnormal_foot_pigmentation1.24712531
86MP0004808_abnormal_hematopoietic_stem1.24036625
87MP0010307_abnormal_tumor_latency1.23493247
88MP0002132_abnormal_respiratory_system1.22798720
89MP0002723_abnormal_immune_serum1.22024425
90MP0004147_increased_porphyrin_level1.22020755
91MP0005360_urolithiasis1.21668261
92MP0003329_amyloid_beta_deposits1.21328375
93MP0002722_abnormal_immune_system1.18783977
94MP0005025_abnormal_response_to1.18149079
95MP0002420_abnormal_adaptive_immunity1.17670351
96MP0001819_abnormal_immune_cell1.17570752
97MP0003724_increased_susceptibility_to1.17128068
98MP0000689_abnormal_spleen_morphology1.16899216
99MP0001440_abnormal_grooming_behavior1.15592242
100MP0003950_abnormal_plasma_membrane1.15220987
101MP0001545_abnormal_hematopoietic_system1.14550330
102MP0005397_hematopoietic_system_phenotyp1.14550330
103MP0001800_abnormal_humoral_immune1.14434134
104MP0001486_abnormal_startle_reflex1.14218367
105MP0002429_abnormal_blood_cell1.12978177
106MP0008438_abnormal_cutaneous_collagen1.11925137
107MP0002229_neurodegeneration1.10124584
108MP0001845_abnormal_inflammatory_respons1.09299693
109MP0003705_abnormal_hypodermis_morpholog1.08521682
110MP0001542_abnormal_bone_strength1.08281857
111MP0005165_increased_susceptibility_to1.07872975
112MP0002693_abnormal_pancreas_physiology1.07461804
113MP0003077_abnormal_cell_cycle1.05916291
114MP0005636_abnormal_mineral_homeostasis1.05901600
115MP0002009_preneoplasia1.05504069
116MP0000681_abnormal_thyroid_gland1.04695765
117MP0004924_abnormal_behavior1.04632126
118MP0005386_behavior/neurological_phenoty1.04632126
119MP0001873_stomach_inflammation1.04448572
120MP0003122_maternal_imprinting1.03710219
121MP0008007_abnormal_cellular_replicative1.03567286
122MP0009840_abnormal_foam_cell1.03094321
123MP0002163_abnormal_gland_morphology1.02835671
124MP0004859_abnormal_synaptic_plasticity1.02469220
125MP0000716_abnormal_immune_system1.01415057
126MP0009763_increased_sensitivity_to1.01224619
127MP0000538_abnormal_urinary_bladder1.00955126
128MP0002019_abnormal_tumor_incidence1.00687504
129MP0002006_tumorigenesis1.00658411
130MP0003091_abnormal_cell_migration0.99084623
131MP0005332_abnormal_amino_acid0.98044360
132MP0001790_abnormal_immune_system0.97241092
133MP0005387_immune_system_phenotype0.97241092
134MP0001963_abnormal_hearing_physiology0.96993398
135MP0003075_altered_response_to0.96905576
136MP0004084_abnormal_cardiac_muscle0.96718867
137MP0005621_abnormal_cell_physiology0.96602263
138MP0006035_abnormal_mitochondrial_morpho0.96377703
139MP0003453_abnormal_keratinocyte_physiol0.95998890
140MP0005645_abnormal_hypothalamus_physiol0.95930182
141MP0003111_abnormal_nucleus_morphology0.95899909
142MP0005535_abnormal_body_temperature0.94831599
143MP0008932_abnormal_embryonic_tissue0.94245543
144MP0005166_decreased_susceptibility_to0.93471696
145MP0002184_abnormal_innervation0.93440124
146MP0001879_abnormal_lymphatic_vessel0.93414690
147MP0000685_abnormal_immune_system0.93114844
148MP0004782_abnormal_surfactant_physiolog0.92795160
149MP0002405_respiratory_system_inflammati0.92384844
150MP0005501_abnormal_skin_physiology0.91566261
151MP0000566_synostosis0.91442680
152MP0003633_abnormal_nervous_system0.90730686
153MP0003868_abnormal_feces_composition0.90511919
154MP0001730_embryonic_growth_arrest0.89700697
155MP0001485_abnormal_pinna_reflex0.89223166
156MP0002909_abnormal_adrenal_gland0.88831202
157MP0001851_eye_inflammation0.88540328
158MP0001664_abnormal_digestion0.87955786
159MP0005058_abnormal_lysosome_morphology0.87405462
160MP0001177_atelectasis0.87029807
161MP0005409_darkened_coat_color0.86838938
162MP0002557_abnormal_social/conspecific_i0.86159414
163MP0005083_abnormal_biliary_tract0.86021808
164MP0001533_abnormal_skeleton_physiology0.85962191
165MP0003631_nervous_system_phenotype0.85597455
166MP0000703_abnormal_thymus_morphology0.85066898
167MP0000015_abnormal_ear_pigmentation0.84515926
168MP0009764_decreased_sensitivity_to0.84219925
169MP0002751_abnormal_autonomic_nervous0.83239448
170MP0008057_abnormal_DNA_replication0.82951439
171MP0002822_catalepsy0.82291016
172MP0003656_abnormal_erythrocyte_physiolo0.82036776
173MP0002066_abnormal_motor_capabilities/c0.81254000
174MP0000778_abnormal_nervous_system0.80841419
175MP0008469_abnormal_protein_level0.80666437
176MP0005023_abnormal_wound_healing0.80209929
177MP0006054_spinal_hemorrhage0.79856510
178MP0001666_abnormal_nutrient_absorption0.79835594
179MP0002796_impaired_skin_barrier0.78191224
180MP0000358_abnormal_cell_content/0.77980331
181MP0001944_abnormal_pancreas_morphology0.77964429
182MP0000639_abnormal_adrenal_gland0.77840507
183MP0009765_abnormal_xenobiotic_induced0.77672962
184MP0000230_abnormal_systemic_arterial0.77495509
185MP0008775_abnormal_heart_ventricle0.77454375
186MP0000350_abnormal_cell_proliferation0.77371607
187MP0005384_cellular_phenotype0.77028461
188MP0000955_abnormal_spinal_cord0.75356501
189MP0000604_amyloidosis0.74011556

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)5.80851792
2Abnormal platelet volume (HP:0011876)5.49162011
3Prolonged bleeding time (HP:0003010)5.31015445
4Petechiae (HP:0000967)5.26791582
5Acute necrotizing encephalopathy (HP:0006965)4.80573606
6Hypothermia (HP:0002045)4.73673051
7Menorrhagia (HP:0000132)4.54745802
8Abnormal mitochondria in muscle tissue (HP:0008316)4.40956651
9Epistaxis (HP:0000421)4.24283047
10Mitochondrial inheritance (HP:0001427)4.15625482
11Progressive macrocephaly (HP:0004481)4.14583087
12Acute encephalopathy (HP:0006846)4.13812194
13Purpura (HP:0000979)3.99545495
14Abnormality of glycolysis (HP:0004366)3.94688493
15Increased serum pyruvate (HP:0003542)3.94688493
16Gingival bleeding (HP:0000225)3.86288574
17Hepatocellular necrosis (HP:0001404)3.80131412
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.75291315
19Increased CSF lactate (HP:0002490)3.70350129
20Atonic seizures (HP:0010819)3.69053577
21Neuroendocrine neoplasm (HP:0100634)3.64294438
22Pheochromocytoma (HP:0002666)3.58117211
23Hyperventilation (HP:0002883)3.57555295
24Hepatic necrosis (HP:0002605)3.50098826
25Abnormal platelet function (HP:0011869)3.34221944
26Impaired platelet aggregation (HP:0003540)3.34221944
27Focal motor seizures (HP:0011153)3.31019847
28Renal Fanconi syndrome (HP:0001994)3.25559033
29Autoimmune hemolytic anemia (HP:0001890)3.06324277
30Abnormal hair whorl (HP:0010721)2.98490335
31Cerebral edema (HP:0002181)2.98004007
32Conjugated hyperbilirubinemia (HP:0002908)2.95922383
333-Methylglutaconic aciduria (HP:0003535)2.93660364
34Autoamputation (HP:0001218)2.88559003
35Increased hepatocellular lipid droplets (HP:0006565)2.84890808
36Abnormal hemoglobin (HP:0011902)2.83327462
37Abnormal gallbladder physiology (HP:0012438)2.81297086
38Cholecystitis (HP:0001082)2.81297086
39Parakeratosis (HP:0001036)2.78650929
40Dyschromatopsia (HP:0007641)2.77673307
41Hyperlipoproteinemia (HP:0010980)2.74909097
42Spontaneous hematomas (HP:0007420)2.70182756
43Papillary thyroid carcinoma (HP:0002895)2.68167386
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.64974052
45Lipid accumulation in hepatocytes (HP:0006561)2.64526903
46Lactic acidosis (HP:0003128)2.63322688
47Medial flaring of the eyebrow (HP:0010747)2.62882428
48Termporal pattern (HP:0011008)2.62855751
49Insidious onset (HP:0003587)2.62855751
50Leukodystrophy (HP:0002415)2.60595886
51Prolonged partial thromboplastin time (HP:0003645)2.60286891
52Short middle phalanx of the 5th finger (HP:0004220)2.59589063
53Abnormality of macrophages (HP:0004311)2.59530289
54Abnormality of the common coagulation pathway (HP:0010990)2.58929260
55Hepatosplenomegaly (HP:0001433)2.58433944
56Polycythemia (HP:0001901)2.57158681
57Ankyloglossia (HP:0010296)2.55546866
58Poikilocytosis (HP:0004447)2.52560536
59Type I transferrin isoform profile (HP:0003642)2.51937360
60Conjunctival telangiectasia (HP:0000524)2.49756044
61Tetraparesis (HP:0002273)2.48729414
62Myocardial infarction (HP:0001658)2.47492018
63Abnormal auditory evoked potentials (HP:0006958)2.44483821
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.42327427
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42327427
66Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39956214
67Absence seizures (HP:0002121)2.38871287
68Abnormality of oral frenula (HP:0000190)2.38741740
69Nausea (HP:0002018)2.35834377
70Dialeptic seizures (HP:0011146)2.34980896
71Respiratory failure (HP:0002878)2.34799022
72Congenital primary aphakia (HP:0007707)2.34678337
73Optic disc pallor (HP:0000543)2.34359498
74Gait imbalance (HP:0002141)2.33863579
75Upper limb muscle weakness (HP:0003484)2.31107590
76Epileptic encephalopathy (HP:0200134)2.31021412
77Abnormal protein glycosylation (HP:0012346)2.30407098
78Abnormal glycosylation (HP:0012345)2.30407098
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.30407098
80Abnormal protein N-linked glycosylation (HP:0012347)2.30407098
81Exercise intolerance (HP:0003546)2.28635550
82Increased serum lactate (HP:0002151)2.28626090
83Nephrogenic diabetes insipidus (HP:0009806)2.28585835
84Aplastic anemia (HP:0001915)2.26441125
85Mucosal telangiectasiae (HP:0100579)2.25906063
86Fatigue (HP:0012378)2.23843440
87Poor suck (HP:0002033)2.21394296
88Acanthocytosis (HP:0001927)2.21330158
89Increased intramyocellular lipid droplets (HP:0012240)2.20629538
90Intrahepatic cholestasis (HP:0001406)2.20403151
91Glycosuria (HP:0003076)2.18627415
92Abnormality of urine glucose concentration (HP:0011016)2.18627415
93Generalized aminoaciduria (HP:0002909)2.17944150
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17045083
95Obstructive lung disease (HP:0006536)2.16916352
96Chronic obstructive pulmonary disease (HP:0006510)2.16916352
97Hypobetalipoproteinemia (HP:0003563)2.16909382
98Cerebral hemorrhage (HP:0001342)2.15994834
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15830798
100Reduced antithrombin III activity (HP:0001976)2.13936402
101Paralysis (HP:0003470)2.12715842
102Febrile seizures (HP:0002373)2.10785870
103X-linked dominant inheritance (HP:0001423)2.10343386
104Thyroid carcinoma (HP:0002890)2.09951179
105Bruising susceptibility (HP:0000978)2.07829539
106T lymphocytopenia (HP:0005403)2.07587613
107Genital tract atresia (HP:0001827)2.06614589
108Dysautonomia (HP:0002459)2.06267630
109Fat malabsorption (HP:0002630)2.04958554
110Abnormality of renal resorption (HP:0011038)2.04904749
111Hyperphosphaturia (HP:0003109)2.04172028
112Fair hair (HP:0002286)2.04041058
113Generalized hypopigmentation of hair (HP:0011358)2.01801430
114Retinal dysplasia (HP:0007973)2.01658534
115Vaginal atresia (HP:0000148)2.00296655
116Abnormality of the anterior horn cell (HP:0006802)1.98354738
117Degeneration of anterior horn cells (HP:0002398)1.98354738
118Deep philtrum (HP:0002002)1.97532011
119Epiphyseal stippling (HP:0010655)1.97009503
120Steatorrhea (HP:0002570)1.96492013
121CNS demyelination (HP:0007305)1.96195390
122Spinal cord lesions (HP:0100561)1.94935072
123Syringomyelia (HP:0003396)1.94935072
124Abnormal umbilical cord blood vessels (HP:0011403)1.94844304
125Single umbilical artery (HP:0001195)1.94844304
126Abnormality of the fetal cardiovascular system (HP:0010948)1.94844304
127Recurrent viral infections (HP:0004429)1.94783752
128Symptomatic seizures (HP:0011145)1.94670112
129Methylmalonic acidemia (HP:0002912)1.94669057
130Muscular hypotonia of the trunk (HP:0008936)1.94605582
131Loss of speech (HP:0002371)1.94453803
132Abnormality of the prostate (HP:0008775)1.92860179
133Abnormality of the intrinsic pathway (HP:0010989)1.92332943
134Recurrent abscess formation (HP:0002722)1.91549615
135Abnormality of T cell number (HP:0011839)1.91470114
136Thrombocytosis (HP:0001894)1.91116679
137Tinnitus (HP:0000360)1.91096676
138Increased IgM level (HP:0003496)1.90354312
139Lower limb hyperreflexia (HP:0002395)1.89873445
140Osteolytic defects of the hand bones (HP:0009699)1.87864153
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.87864153
142Metaphyseal dysplasia (HP:0100255)1.87260189
143Rhabdomyosarcoma (HP:0002859)1.86178930
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85526221
145Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85526221
146Hypokinesia (HP:0002375)1.85255694
147Lethargy (HP:0001254)1.84920717
148Abnormal autonomic nervous system physiology (HP:0012332)1.84799717
149Vertebral compression fractures (HP:0002953)1.84142218
150Abnormality of alanine metabolism (HP:0010916)1.83310847
151Hyperalaninemia (HP:0003348)1.83310847
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83310847
153Spondylolisthesis (HP:0003302)1.82585964
154Sensory axonal neuropathy (HP:0003390)1.81377597
155Disproportionate short-trunk short stature (HP:0003521)1.80677478
156Generalized tonic-clonic seizures (HP:0002069)1.80589004
157Myelodysplasia (HP:0002863)1.79057680
158Oligomenorrhea (HP:0000876)1.78256474
159Cutaneous melanoma (HP:0012056)1.76817345
160Epileptiform EEG discharges (HP:0011182)1.75651012
161Periodontitis (HP:0000704)1.75472908
162Acute myeloid leukemia (HP:0004808)1.75338359
163Poor speech (HP:0002465)1.75137028
164Limb dystonia (HP:0002451)1.75064597
165Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74593799
166Methylmalonic aciduria (HP:0012120)1.74147848
167Conjunctival hamartoma (HP:0100780)1.73525212
168Spastic paraparesis (HP:0002313)1.73446202
169Pancreatic fibrosis (HP:0100732)1.72706493
170Increased muscle lipid content (HP:0009058)1.72279887
171Urticaria (HP:0001025)1.71192096
172Renal tubular dysfunction (HP:0000124)1.70238228
173Decreased skull ossification (HP:0004331)1.69924373
174Hypoglycemic seizures (HP:0002173)1.69710645
175Orthostatic hypotension (HP:0001278)1.69300562
176Brushfield spots (HP:0001088)1.68146469
177Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68141411
178Irregular epiphyses (HP:0010582)1.67813009
179Abnormality of skull ossification (HP:0002703)1.66668850
180Cholelithiasis (HP:0001081)1.66577325
181Arterial thrombosis (HP:0004420)1.66423599
182Abnormality of the umbilical cord (HP:0010881)1.65031052
183Abnormality of iron homeostasis (HP:0011031)1.64268583
184Joint swelling (HP:0001386)1.62715302
185Eczematoid dermatitis (HP:0000976)1.62011258
186Progressive hearing impairment (HP:0001730)1.61648367
187Recurrent bacterial skin infections (HP:0005406)1.60777143
188Delayed closure of the anterior fontanelle (HP:0001476)1.59491718
189Stomatitis (HP:0010280)1.58025192
190Premature rupture of membranes (HP:0001788)1.57114237
191Dysostosis multiplex (HP:0000943)1.56576969
192Chest pain (HP:0100749)1.56438756
193Male infertility (HP:0003251)1.54979326
194Abnormality of liposaccharide metabolism (HP:0010968)1.54512272
195Abnormality of glycosphingolipid metabolism (HP:0004343)1.54512272
196Abnormality of glycolipid metabolism (HP:0010969)1.54512272
197Glomerulopathy (HP:0100820)1.54016990
198Neoplasm of the rectum (HP:0100743)1.52397516

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.19445053
2MAP3K122.99802110
3BMPR1B2.47665622
4STK162.38254772
5MAP2K72.32356811
6ARAF2.31718721
7OXSR12.30743228
8MST42.17198871
9LIMK12.12570341
10IRAK32.11940932
11BCR2.11195670
12CDK192.04309083
13BMPR22.03089546
14MAP2K31.99303879
15PLK21.90969126
16PBK1.85393669
17NLK1.76015689
18FRK1.67500858
19STK391.65637954
20NEK11.65457381
21INSRR1.64111000
22AKT31.63569469
23CCNB11.60865120
24STK101.53575731
25EIF2AK31.53530426
26NME21.40946135
27BMX1.40722024
28NME11.39826460
29MAP3K31.38859925
30CLK11.33281121
31ADRBK21.32558814
32ILK1.30750171
33BTK1.30713488
34NEK91.28215344
35NTRK31.28126198
36CSNK1G31.26033626
37MAP3K61.25669067
38CSF1R1.23793063
39MAP3K41.20795111
40ZAP701.20484843
41CAMKK21.18044546
42ERBB31.16378182
43STK31.14463083
44SCYL21.12444741
45CAMK2B1.11090149
46BRSK21.09509968
47MYLK1.09030488
48BRAF1.08315346
49PRKCE1.07959479
50TRIM281.07722186
51TAOK21.06661631
52NTRK11.06069541
53MAPKAPK51.05830643
54LRRK21.05409023
55ERBB41.04421041
56RAF11.03134309
57MAP3K131.02770924
58MAP3K51.00800428
59PAK11.00285775
60SYK1.00001955
61TSSK60.99953834
62CSNK1G20.99904916
63MAPK150.99328459
64DAPK10.99288920
65YES10.99191375
66MINK10.98352524
67TYK20.95475138
68SGK2230.95435286
69SGK4940.95435286
70JAK30.95360911
71SIK30.93033877
72NEK60.92306225
73CSNK1G10.91344640
74HCK0.91014812
75PAK40.90819340
76TTK0.90300562
77GRK50.89327458
78EIF2AK10.87365319
79CDK30.85529700
80WNK40.84779536
81CSNK1A1L0.84463518
82CDK80.83804872
83MAP3K80.83544787
84CAMK2A0.82963742
85PIK3CG0.81505669
86JAK10.81130034
87CDK60.80527447
88PIM20.79902735
89FLT30.79838319
90CAMK2D0.79813665
91CSK0.79758120
92KSR20.79653091
93GRK70.78479279
94VRK10.78228935
95MAP3K140.78079568
96TBK10.76299049
97MAP2K40.76022865
98UHMK10.75899653
99CAMK2G0.75119515
100MARK30.74793784
101MAPK130.74787166
102WNK30.70569885
103MET0.70333001
104TESK10.69924244
105MKNK10.67912239
106IRAK40.67623950
107TESK20.66258982
108RIPK40.65075512
109DYRK20.64943116
110PIK3CA0.64639971
111PASK0.63368172
112ADRBK10.62757795
113IKBKB0.62565964
114PDK30.61138205
115PDK40.61138205
116EIF2AK20.60818893
117IRAK10.59201856
118KSR10.58521799
119MKNK20.58010739
120DAPK20.57853724
121WEE10.57013850
122TEC0.56777865
123MAP3K10.56663107
124CDK40.56437541
125PRKCG0.56405624
126FGR0.56128533
127NEK20.55584096
128CDK90.55294331
129EPHA40.55058322
130SGK20.54504978
131STK240.53919320
132JAK20.53614943
133PDK20.53606496
134IKBKE0.53433287
135STK40.53118372
136PRPF4B0.53005750
137KIT0.52779695
138MOS0.52617200
139CDC70.50950451
140PTK2B0.50431338
141TNIK0.50139871
142SGK30.49663415
143BUB10.48688300
144ACVR1B0.48263502
145TAOK30.47957879
146PAK20.47369542
147PLK30.46952830
148TXK0.46568877
149CDK70.46368092
150ITK0.46301470
151LYN0.46139599
152FES0.45980146
153CDK140.45128414
154CDK50.44363703
155PKN10.42429803
156TGFBR20.42333339
157MATK0.41493691
158TRPM70.41256965
159PRKACA0.40775423
160GRK60.40529363
161BCKDK0.39905638
162IRAK20.39733467
163MUSK0.39304553
164BLK0.38381732
165MST1R0.37592648
166MAPKAPK30.37093234
167CDK180.36980514
168FER0.36881209
169DYRK1A0.35991346
170MAP3K20.35583990

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.63243160
2Oxidative phosphorylation_Homo sapiens_hsa001903.83114498
3Collecting duct acid secretion_Homo sapiens_hsa049662.90795433
4Sulfur metabolism_Homo sapiens_hsa009202.89693707
5Platelet activation_Homo sapiens_hsa046112.79360009
6Parkinsons disease_Homo sapiens_hsa050122.75513379
7Proteasome_Homo sapiens_hsa030502.66629995
8Fatty acid elongation_Homo sapiens_hsa000622.53605398
9Vibrio cholerae infection_Homo sapiens_hsa051102.51256385
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.50933012
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.49470540
12Alzheimers disease_Homo sapiens_hsa050102.30936060
13Steroid biosynthesis_Homo sapiens_hsa001002.24708999
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17717303
15Shigellosis_Homo sapiens_hsa051312.16181652
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11977276
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.00369224
18Synaptic vesicle cycle_Homo sapiens_hsa047211.88789680
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87753462
20Hematopoietic cell lineage_Homo sapiens_hsa046401.84710451
21Pentose phosphate pathway_Homo sapiens_hsa000301.84565747
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82866717
23* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.80679152
24Pancreatic cancer_Homo sapiens_hsa052121.77233578
25Huntingtons disease_Homo sapiens_hsa050161.75645381
26Legionellosis_Homo sapiens_hsa051341.74898223
27Mismatch repair_Homo sapiens_hsa034301.72487954
28Histidine metabolism_Homo sapiens_hsa003401.65720936
29Leishmaniasis_Homo sapiens_hsa051401.60992142
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59475220
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56304927
32Thyroid cancer_Homo sapiens_hsa052161.53274791
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48953814
34Measles_Homo sapiens_hsa051621.48784456
35B cell receptor signaling pathway_Homo sapiens_hsa046621.47596079
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39140741
37Non-small cell lung cancer_Homo sapiens_hsa052231.39096710
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37454046
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.36808286
40Nicotine addiction_Homo sapiens_hsa050331.36197410
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33777868
42Phagosome_Homo sapiens_hsa041451.32933855
43Cell cycle_Homo sapiens_hsa041101.32892361
44Peroxisome_Homo sapiens_hsa041461.32146813
45Rheumatoid arthritis_Homo sapiens_hsa053231.32062243
46Folate biosynthesis_Homo sapiens_hsa007901.31156814
47Herpes simplex infection_Homo sapiens_hsa051681.30980870
48Butanoate metabolism_Homo sapiens_hsa006501.30714766
49Chronic myeloid leukemia_Homo sapiens_hsa052201.29954898
50Osteoclast differentiation_Homo sapiens_hsa043801.28852371
51Pyruvate metabolism_Homo sapiens_hsa006201.27695616
52Influenza A_Homo sapiens_hsa051641.26786610
53Asthma_Homo sapiens_hsa053101.23473483
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23256068
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22629921
56Malaria_Homo sapiens_hsa051441.21392168
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.17296450
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16370988
59Antigen processing and presentation_Homo sapiens_hsa046121.15119789
60Regulation of autophagy_Homo sapiens_hsa041401.13442182
61Vitamin B6 metabolism_Homo sapiens_hsa007501.11817770
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11302131
63Viral carcinogenesis_Homo sapiens_hsa052031.09160365
64Hepatitis B_Homo sapiens_hsa051611.08626644
65Chemokine signaling pathway_Homo sapiens_hsa040621.08095039
66Tyrosine metabolism_Homo sapiens_hsa003501.06365098
67Toxoplasmosis_Homo sapiens_hsa051451.06068567
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05909235
69Phenylalanine metabolism_Homo sapiens_hsa003601.05287083
70Tuberculosis_Homo sapiens_hsa051521.05170096
71Allograft rejection_Homo sapiens_hsa053301.04846900
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04372801
73Endocytosis_Homo sapiens_hsa041441.02560618
74Autoimmune thyroid disease_Homo sapiens_hsa053201.02109870
75Acute myeloid leukemia_Homo sapiens_hsa052211.02070163
76RNA polymerase_Homo sapiens_hsa030201.01857188
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01102847
78Salmonella infection_Homo sapiens_hsa051321.00652815
79Serotonergic synapse_Homo sapiens_hsa047260.99710987
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99710249
81GABAergic synapse_Homo sapiens_hsa047270.99130810
82DNA replication_Homo sapiens_hsa030300.98621291
83Taste transduction_Homo sapiens_hsa047420.98547904
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96898680
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94177389
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93787517
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93617143
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.93444751
89Sphingolipid metabolism_Homo sapiens_hsa006000.92525054
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91552649
91Small cell lung cancer_Homo sapiens_hsa052220.91456720
92Chemical carcinogenesis_Homo sapiens_hsa052040.90957793
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.90650652
94Renal cell carcinoma_Homo sapiens_hsa052110.89421097
95Nucleotide excision repair_Homo sapiens_hsa034200.86738090
96Apoptosis_Homo sapiens_hsa042100.86241391
97Metabolic pathways_Homo sapiens_hsa011000.85483097
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85369827
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.85263471
100T cell receptor signaling pathway_Homo sapiens_hsa046600.85017141
101Hepatitis C_Homo sapiens_hsa051600.85015719
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84428173
103Graft-versus-host disease_Homo sapiens_hsa053320.84138917
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83153936
105Viral myocarditis_Homo sapiens_hsa054160.82292560
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81427738
107Propanoate metabolism_Homo sapiens_hsa006400.81087476
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80815123
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80565742
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80326913
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79449536
112beta-Alanine metabolism_Homo sapiens_hsa004100.78737252
113Amphetamine addiction_Homo sapiens_hsa050310.77678313
114Tryptophan metabolism_Homo sapiens_hsa003800.76197691
115Basal transcription factors_Homo sapiens_hsa030220.75255152
116Bladder cancer_Homo sapiens_hsa052190.75104953
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75043582
118Insulin secretion_Homo sapiens_hsa049110.74096311
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73547064
120Epstein-Barr virus infection_Homo sapiens_hsa051690.72323024
121Type I diabetes mellitus_Homo sapiens_hsa049400.71121793
122Amoebiasis_Homo sapiens_hsa051460.71022834
123Prostate cancer_Homo sapiens_hsa052150.70173884
124N-Glycan biosynthesis_Homo sapiens_hsa005100.69636610
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69354152
126Arginine and proline metabolism_Homo sapiens_hsa003300.68445490
127Staphylococcus aureus infection_Homo sapiens_hsa051500.68437299
128p53 signaling pathway_Homo sapiens_hsa041150.68019078
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.67794656
130Inositol phosphate metabolism_Homo sapiens_hsa005620.67482234
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66606242
132Ether lipid metabolism_Homo sapiens_hsa005650.66509391
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66197985
134Glutathione metabolism_Homo sapiens_hsa004800.64210571
135Morphine addiction_Homo sapiens_hsa050320.63259872
136Carbon metabolism_Homo sapiens_hsa012000.62538598
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.62373414
138Dopaminergic synapse_Homo sapiens_hsa047280.61560281
139Pertussis_Homo sapiens_hsa051330.61447974
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60293394
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.57513520
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57192219
143Focal adhesion_Homo sapiens_hsa045100.56556008
144TNF signaling pathway_Homo sapiens_hsa046680.56340919
145Proteoglycans in cancer_Homo sapiens_hsa052050.55785323
146Endometrial cancer_Homo sapiens_hsa052130.55319230
147One carbon pool by folate_Homo sapiens_hsa006700.54823674
148Glioma_Homo sapiens_hsa052140.53449916
149Retinol metabolism_Homo sapiens_hsa008300.53361857
150Lysosome_Homo sapiens_hsa041420.52443514
151Oocyte meiosis_Homo sapiens_hsa041140.51554029
152RNA transport_Homo sapiens_hsa030130.51459154
153VEGF signaling pathway_Homo sapiens_hsa043700.51134732
154Other glycan degradation_Homo sapiens_hsa005110.51018027
155Cocaine addiction_Homo sapiens_hsa050300.50558438
156Insulin signaling pathway_Homo sapiens_hsa049100.50302176
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49525201
158Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49160067
159Sphingolipid signaling pathway_Homo sapiens_hsa040710.49119651
160Circadian entrainment_Homo sapiens_hsa047130.48649981
161Purine metabolism_Homo sapiens_hsa002300.48429861
162Complement and coagulation cascades_Homo sapiens_hsa046100.46016737
163Glutamatergic synapse_Homo sapiens_hsa047240.43855422
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43186613
165Cardiac muscle contraction_Homo sapiens_hsa042600.41625572
166Pyrimidine metabolism_Homo sapiens_hsa002400.39975362
167Starch and sucrose metabolism_Homo sapiens_hsa005000.39616053
168Arachidonic acid metabolism_Homo sapiens_hsa005900.39096658
169Selenocompound metabolism_Homo sapiens_hsa004500.38890496
170Olfactory transduction_Homo sapiens_hsa047400.37264816
171Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33934419
172Caffeine metabolism_Homo sapiens_hsa002320.32511011
173Fatty acid metabolism_Homo sapiens_hsa012120.31412659
174Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30746671
175Fatty acid degradation_Homo sapiens_hsa000710.30019406
176Long-term potentiation_Homo sapiens_hsa047200.28612758
177Vitamin digestion and absorption_Homo sapiens_hsa049770.28478962
178Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26610540
179Galactose metabolism_Homo sapiens_hsa000520.25286724
180Renin-angiotensin system_Homo sapiens_hsa046140.23418130

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