VAMP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.66146910
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87373271
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05761898
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05761898
5response to interferon-beta (GO:0035456)3.95534634
6antigen processing and presentation of endogenous antigen (GO:0019883)3.81704319
7viral transcription (GO:0019083)3.65771236
8purine deoxyribonucleotide catabolic process (GO:0009155)3.62561174
9neutrophil activation involved in immune response (GO:0002283)3.55610910
10translational termination (GO:0006415)3.47240404
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35833422
12negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.33700378
13antigen processing and presentation via MHC class Ib (GO:0002475)3.32914248
14DNA deamination (GO:0045006)3.29112716
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28741490
16protein targeting to ER (GO:0045047)3.25141076
17cotranslational protein targeting to membrane (GO:0006613)3.24674774
18response to interferon-alpha (GO:0035455)3.23352582
19immunoglobulin mediated immune response (GO:0016064)3.21237192
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15506168
21ribosomal small subunit biogenesis (GO:0042274)3.11449605
22protein localization to endoplasmic reticulum (GO:0070972)3.11061498
23response to peptidoglycan (GO:0032494)3.10516143
24deoxyribonucleotide catabolic process (GO:0009264)3.09639572
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05850548
26mature B cell differentiation involved in immune response (GO:0002313)3.04127126
27deoxyribose phosphate catabolic process (GO:0046386)3.03843150
28response to type I interferon (GO:0034340)3.00674351
29type I interferon signaling pathway (GO:0060337)2.99332931
30cellular response to type I interferon (GO:0071357)2.99332931
31translational elongation (GO:0006414)2.96884242
32positive regulation of gamma-delta T cell activation (GO:0046645)2.93931899
33defense response to protozoan (GO:0042832)2.88012882
34production of molecular mediator involved in inflammatory response (GO:0002532)2.87565939
35cellular response to interferon-beta (GO:0035458)2.87235629
36response to protozoan (GO:0001562)2.84640279
37Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81552566
38positive regulation of interferon-alpha production (GO:0032727)2.78528224
39reactive oxygen species biosynthetic process (GO:1903409)2.78190894
40negative regulation of B cell apoptotic process (GO:0002903)2.77165081
41regulation of mast cell degranulation (GO:0043304)2.76496547
42respiratory burst (GO:0045730)2.74021867
43viral life cycle (GO:0019058)2.73336269
44positive regulation of B cell differentiation (GO:0045579)2.72847987
45positive regulation of monocyte chemotaxis (GO:0090026)2.71606865
46endosome to pigment granule transport (GO:0043485)2.71349008
47endosome to melanosome transport (GO:0035646)2.71349008
48hydrogen peroxide biosynthetic process (GO:0050665)2.70526397
49negative regulation of growth of symbiont in host (GO:0044130)2.70083471
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.70083471
51modulation of growth of symbiont involved in interaction with host (GO:0044144)2.70083471
52regulation of growth of symbiont in host (GO:0044126)2.70083471
53negative regulation of viral genome replication (GO:0045071)2.69127586
54actin nucleation (GO:0045010)2.68555922
55platelet dense granule organization (GO:0060155)2.66599888
56purine nucleotide salvage (GO:0032261)2.65956039
57regulation of B cell apoptotic process (GO:0002902)2.63125120
58maturation of SSU-rRNA (GO:0030490)2.62781369
59regulation of interferon-alpha production (GO:0032647)2.61751902
60B cell mediated immunity (GO:0019724)2.60912225
61positive regulation of natural killer cell differentiation (GO:0032825)2.60276458
62positive regulation of antigen processing and presentation (GO:0002579)2.59728798
63myeloid dendritic cell activation (GO:0001773)2.58941082
64regulation of inflammatory response to antigenic stimulus (GO:0002861)2.58525566
65cellular response to zinc ion (GO:0071294)2.58483402
66negative regulation of interleukin-12 production (GO:0032695)2.57506407
67definitive hemopoiesis (GO:0060216)2.57363924
68purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.57352515
69positive regulation of mast cell degranulation (GO:0043306)2.56767045
70positive regulation of mast cell activation involved in immune response (GO:0033008)2.56767045
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.56748738
72myeloid cell activation involved in immune response (GO:0002275)2.56424893
73regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54116574
74regulation of dendritic cell antigen processing and presentation (GO:0002604)2.52831775
75regulation of RIG-I signaling pathway (GO:0039535)2.50725013
76signal peptide processing (GO:0006465)2.50017806
77purine deoxyribonucleotide metabolic process (GO:0009151)2.48666942
78negative regulation of myeloid cell apoptotic process (GO:0033033)2.48600321
79regulation of mast cell activation involved in immune response (GO:0033006)2.47001535
80regulation of natural killer cell differentiation (GO:0032823)2.46733719
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46691025
82daunorubicin metabolic process (GO:0044597)2.46188440
83polyketide metabolic process (GO:0030638)2.46188440
84doxorubicin metabolic process (GO:0044598)2.46188440
85positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45269202
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45040702
87cellular response to interferon-gamma (GO:0071346)2.44603874
88positive regulation of prostaglandin secretion (GO:0032308)2.43416177
89positive regulation of respiratory burst (GO:0060267)2.43347563
90neutrophil activation (GO:0042119)2.43016076
91cellular protein complex disassembly (GO:0043624)2.42644480
92positive thymic T cell selection (GO:0045059)2.41732204
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40322544
94cellular extravasation (GO:0045123)2.40182992
95positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.39928077
96cellular response to exogenous dsRNA (GO:0071360)2.39221583
97regulation of superoxide anion generation (GO:0032928)2.38425446
98glycosphingolipid catabolic process (GO:0046479)2.37343561
99regulation of gamma-delta T cell differentiation (GO:0045586)2.37264823
100granulocyte activation (GO:0036230)2.36950823
101interferon-gamma-mediated signaling pathway (GO:0060333)2.36812861
102response to interferon-gamma (GO:0034341)2.36233237
103detection of other organism (GO:0098543)2.35912672
104regulation of leukocyte degranulation (GO:0043300)2.35568484
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.34575073
106positive regulation of mast cell activation (GO:0033005)2.34445200
107regulation of interferon-beta biosynthetic process (GO:0045357)2.32749532
108superoxide anion generation (GO:0042554)2.32151607
109regulation of B cell receptor signaling pathway (GO:0050855)2.31587740
110positive regulation of lymphocyte migration (GO:2000403)2.31433500
111translational initiation (GO:0006413)2.31310670
112toxin transport (GO:1901998)2.31102947
113regulation of mast cell activation (GO:0033003)2.30736832
114surfactant homeostasis (GO:0043129)2.29695656
115deoxyribose phosphate metabolic process (GO:0019692)2.29587092
116chaperone mediated protein folding requiring cofactor (GO:0051085)2.29066138
117antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.28794940
118positive regulation of T cell migration (GO:2000406)2.28723468
119mast cell activation (GO:0045576)2.28276941
120regulation of antigen processing and presentation (GO:0002577)2.28119670
121amino sugar catabolic process (GO:0046348)2.27415481
1222-deoxyribonucleotide metabolic process (GO:0009394)2.26467455
123regulation of chemokine biosynthetic process (GO:0045073)2.26128198
124myeloid dendritic cell differentiation (GO:0043011)2.26020352
125lipoxygenase pathway (GO:0019372)2.25854870
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.25521179
127pinocytosis (GO:0006907)2.25450466
128regulation of T cell migration (GO:2000404)2.25207683
129cytidine deamination (GO:0009972)2.24976105
130cytidine metabolic process (GO:0046087)2.24976105
131cytidine catabolic process (GO:0006216)2.24976105
132regulation of hypersensitivity (GO:0002883)2.24780957
133nucleotide salvage (GO:0043173)2.24257772
134negative regulation of nitric oxide biosynthetic process (GO:0045019)2.24196623
135deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.24129892
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.24073873
137positive regulation of interferon-beta production (GO:0032728)2.22629714
138positive regulation of neutrophil chemotaxis (GO:0090023)2.22543039
139positive regulation of neutrophil migration (GO:1902624)2.22543039
140glycolipid catabolic process (GO:0019377)2.22299152
141detection of bacterium (GO:0016045)2.21585220
142histamine secretion (GO:0001821)2.20208416
143valine metabolic process (GO:0006573)2.19170896
144regulation of B cell differentiation (GO:0045577)2.18870063
145positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.17131189
146regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.16885921
147positive regulation by symbiont of host defense response (GO:0052509)2.15861842
148modulation by symbiont of host defense response (GO:0052031)2.15861842
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.15861842
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.15861842
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.15861842
152modulation by symbiont of host immune response (GO:0052553)2.15861842
153NIK/NF-kappaB signaling (GO:0038061)2.14081282
154regulation of gamma-delta T cell activation (GO:0046643)2.13196998
155response to muramyl dipeptide (GO:0032495)2.13047207
156xenobiotic catabolic process (GO:0042178)2.12246278
157detection of external biotic stimulus (GO:0098581)2.12067707
158response to thyroid hormone (GO:0097066)2.11225414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.67438219
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.52019823
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.31938851
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25560064
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94913426
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68066817
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67885597
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41881500
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39833670
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39687785
11GATA1_22025678_ChIP-Seq_K562_Human2.36400371
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31959006
13* SCL_19346495_ChIP-Seq_HPC-7_Human2.29552122
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.29259395
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19234775
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18400385
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17258549
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.14526787
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13919175
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.13035810
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12364583
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11845797
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09117973
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07238340
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.02689343
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01120686
27* SPI1_23547873_ChIP-Seq_NB4_Human2.00048975
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94472920
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93608728
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86634710
31E2F7_22180533_ChIP-Seq_HELA_Human1.85464649
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84407996
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79343204
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77465953
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76458959
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.69677418
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63223939
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.62526386
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58234239
40SPI1_23127762_ChIP-Seq_K562_Human1.58172661
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55365385
42* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53139342
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52458651
44* RUNX1_22412390_ChIP-Seq_EML_Mouse1.51122158
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49642472
46BCL6_27268052_Chip-Seq_Bcells_Human1.49396834
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48701973
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48351686
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47680309
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47146148
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46817539
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46250190
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46188197
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44867674
55MYB_26560356_Chip-Seq_TH2_Human1.43648502
56VDR_24763502_ChIP-Seq_THP-1_Human1.40106616
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.40054046
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.39302755
59* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38822944
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.38769809
61* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37883385
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37047665
63* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35836624
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.35669665
65VDR_21846776_ChIP-Seq_THP-1_Human1.34487516
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33944155
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33290430
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.30186299
69MYB_26560356_Chip-Seq_TH1_Human1.29170214
70BCOR_27268052_Chip-Seq_Bcells_Human1.28820034
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.28331574
72MAF_26560356_Chip-Seq_TH1_Human1.28007438
73VDR_23849224_ChIP-Seq_CD4+_Human1.26777968
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24458967
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21240533
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21191003
77STAT1_20625510_ChIP-Seq_HELA_Human1.20454150
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19582783
79* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18238413
80* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16005198
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15766400
82MAF_26560356_Chip-Seq_TH2_Human1.14232454
83P300_27268052_Chip-Seq_Bcells_Human1.12723711
84LXR_22292898_ChIP-Seq_THP-1_Human1.12109299
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.11694265
86ELK1_19687146_ChIP-ChIP_HELA_Human1.10339762
87GATA3_27048872_Chip-Seq_THYMUS_Human1.10307039
88GATA3_26560356_Chip-Seq_TH2_Human1.09831174
89* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07023994
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06912639
91TFEB_21752829_ChIP-Seq_HELA_Human1.04554771
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03350659
93PU_27001747_Chip-Seq_BMDM_Mouse1.02786180
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02466962
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.02208599
96RUNX_20019798_ChIP-Seq_JUKART_Human1.01835969
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01799169
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00742908
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00357738
100SPI1_20517297_ChIP-Seq_HL60_Human1.00198374
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99407530
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99299634
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98320990
104DCP1A_22483619_ChIP-Seq_HELA_Human0.97719892
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97346577
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97238570
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.97093891
108CIITA_25753668_ChIP-Seq_RAJI_Human0.96593032
109UTX_26944678_Chip-Seq_JUKART_Human0.96498471
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96381319
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95961637
112FOXP3_21729870_ChIP-Seq_TREG_Human0.95165873
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94770617
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.94097550
115* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93834992
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93421867
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92328546
118GATA1_19941826_ChIP-Seq_K562_Human0.91259855
119MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90796010
120* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90775385
121* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90414878
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90112867
123MYC_22102868_ChIP-Seq_BL_Human0.89949789
124XRN2_22483619_ChIP-Seq_HELA_Human0.88231578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.57670121
2MP0009785_altered_susceptibility_to2.92570865
3MP0003724_increased_susceptibility_to2.91553488
4MP0003436_decreased_susceptibility_to2.70737459
5* MP0002148_abnormal_hypersensitivity_rea2.48100972
6MP0000685_abnormal_immune_system2.41392495
7MP0005025_abnormal_response_to2.35659881
8MP0005671_abnormal_response_to2.26768837
9MP0003191_abnormal_cellular_cholesterol2.22304409
10MP0002419_abnormal_innate_immunity2.18686690
11MP0005000_abnormal_immune_tolerance2.07374581
12* MP0005464_abnormal_platelet_physiology2.06951867
13MP0003186_abnormal_redox_activity2.02332690
14MP0002139_abnormal_hepatobiliary_system1.94991354
15MP0004782_abnormal_surfactant_physiolog1.91103132
16MP0001790_abnormal_immune_system1.88437681
17MP0005387_immune_system_phenotype1.88437681
18* MP0002452_abnormal_antigen_presenting1.87588647
19MP0001800_abnormal_humoral_immune1.84097201
20MP0001853_heart_inflammation1.83055634
21MP0002723_abnormal_immune_serum1.83037330
22MP0002166_altered_tumor_susceptibility1.81997162
23MP0002396_abnormal_hematopoietic_system1.76398180
24MP0001545_abnormal_hematopoietic_system1.76061240
25MP0005397_hematopoietic_system_phenotyp1.76061240
26MP0005360_urolithiasis1.75795812
27MP0005058_abnormal_lysosome_morphology1.73692793
28MP0010155_abnormal_intestine_physiology1.70944851
29* MP0001819_abnormal_immune_cell1.69937683
30* MP0002420_abnormal_adaptive_immunity1.69573812
31MP0006082_CNS_inflammation1.65724811
32MP0005365_abnormal_bile_salt1.65488380
33MP0005085_abnormal_gallbladder_physiolo1.64413582
34MP0002006_tumorigenesis1.61900479
35MP0009764_decreased_sensitivity_to1.61546522
36MP0008875_abnormal_xenobiotic_pharmacok1.60826291
37MP0003172_abnormal_lysosome_physiology1.60592283
38MP0001845_abnormal_inflammatory_respons1.59648751
39MP0002138_abnormal_hepatobiliary_system1.58484393
40MP0002405_respiratory_system_inflammati1.56412818
41* MP0008469_abnormal_protein_level1.54105945
42MP0004947_skin_inflammation1.51758839
43MP0009840_abnormal_foam_cell1.48772813
44MP0000465_gastrointestinal_hemorrhage1.46969912
45MP0003763_abnormal_thymus_physiology1.43710924
46MP0002132_abnormal_respiratory_system1.42603506
47MP0009333_abnormal_splenocyte_physiolog1.39979457
48MP0002398_abnormal_bone_marrow1.38701988
49MP0006054_spinal_hemorrhage1.38603363
50MP0000490_abnormal_crypts_of1.38233455
51MP0001533_abnormal_skeleton_physiology1.36750873
52MP0000716_abnormal_immune_system1.36434818
53MP0001873_stomach_inflammation1.35149559
54MP0006036_abnormal_mitochondrial_physio1.34025796
55MP0005166_decreased_susceptibility_to1.33350330
56MP0000689_abnormal_spleen_morphology1.26327314
57MP0004808_abnormal_hematopoietic_stem1.23676595
58MP0002429_abnormal_blood_cell1.22583421
59MP0003806_abnormal_nucleotide_metabolis1.22299786
60MP0002722_abnormal_immune_system1.21350736
61MP0005083_abnormal_biliary_tract1.20873119
62MP0003656_abnormal_erythrocyte_physiolo1.20720597
63MP0005165_increased_susceptibility_to1.19954609
64MP0001666_abnormal_nutrient_absorption1.19178855
65MP0002254_reproductive_system_inflammat1.18913659
66MP0005451_abnormal_body_composition1.18465431
67MP0009379_abnormal_foot_pigmentation1.16872153
68MP0000858_altered_metastatic_potential1.15966285
69MP0000343_altered_response_to1.15415914
70MP0005174_abnormal_tail_pigmentation1.12897192
71MP0005075_abnormal_melanosome_morpholog1.12019338
72MP0004019_abnormal_vitamin_homeostasis1.11463695
73* MP0009643_abnormal_urine_homeostasis1.10545221
74MP0001764_abnormal_homeostasis1.10206607
75MP0000604_amyloidosis1.10124828
76MP0003866_abnormal_defecation1.01963681
77MP0003693_abnormal_embryo_hatching1.01817966
78MP0003303_peritoneal_inflammation0.97909181
79MP0003183_abnormal_peptide_metabolism0.97427008
80MP0009763_increased_sensitivity_to0.97013583
81MP0010329_abnormal_lipoprotein_level0.96807676
82MP0002877_abnormal_melanocyte_morpholog0.95879453
83MP0002277_abnormal_respiratory_mucosa0.95269953
84MP0003195_calcinosis0.94264713
85MP0000609_abnormal_liver_physiology0.92834889
86MP0003252_abnormal_bile_duct0.91892242
87* MP0005319_abnormal_enzyme/_coenzyme0.90434847
88* MP0002136_abnormal_kidney_physiology0.86017564
89MP0005310_abnormal_salivary_gland0.85618517
90MP0005408_hypopigmentation0.85397383
91MP0003075_altered_response_to0.84882258
92MP0008004_abnormal_stomach_pH0.83505037
93MP0005332_abnormal_amino_acid0.83342091
94MP0005636_abnormal_mineral_homeostasis0.82338384
95MP0001663_abnormal_digestive_system0.81640736
96MP0009278_abnormal_bone_marrow0.80596279
97MP0003300_gastrointestinal_ulcer0.79974369
98MP0000598_abnormal_liver_morphology0.79796308
99MP0002998_abnormal_bone_remodeling0.78320070
100MP0009765_abnormal_xenobiotic_induced0.78040320
101MP0002098_abnormal_vibrissa_morphology0.77302019
102MP0001958_emphysema0.77184479
103MP0004147_increased_porphyrin_level0.77158569
104MP0005084_abnormal_gallbladder_morpholo0.77124302
105MP0003448_altered_tumor_morphology0.77079920
106MP0010368_abnormal_lymphatic_system0.76921901
107MP0000703_abnormal_thymus_morphology0.76750358
108MP0004510_myositis0.76021374
109MP0003638_abnormal_response/metabolism_0.75846015
110MP0008873_increased_physiological_sensi0.73710413
111MP0002019_abnormal_tumor_incidence0.73408177
112MP0003566_abnormal_cell_adhesion0.73163308
113MP0002095_abnormal_skin_pigmentation0.72818316
114MP0008260_abnormal_autophagy0.72228579
115MP0003786_premature_aging0.72095210
116MP0005164_abnormal_response_to0.71885741
117MP0001851_eye_inflammation0.69674601
118* MP0005584_abnormal_enzyme/coenzyme_acti0.69312853
119MP0001881_abnormal_mammary_gland0.69095454

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.31227097
2Recurrent bacterial skin infections (HP:0005406)4.20473092
3Abnormality of glycolipid metabolism (HP:0010969)4.19461004
4Abnormality of liposaccharide metabolism (HP:0010968)4.19461004
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.19461004
6Eczematoid dermatitis (HP:0000976)3.96284824
7Thrombocytosis (HP:0001894)3.76004329
8Petechiae (HP:0000967)3.68464457
9Elevated erythrocyte sedimentation rate (HP:0003565)3.67250178
10Recurrent gram-negative bacterial infections (HP:0005420)3.58914509
11Vacuolated lymphocytes (HP:0001922)3.51547332
12Abnormal number of erythroid precursors (HP:0012131)3.47602628
13Abnormality of cells of the erythroid lineage (HP:0012130)3.46850689
14Interstitial pulmonary disease (HP:0006530)3.28741068
15Agammaglobulinemia (HP:0004432)3.24794020
16Myositis (HP:0100614)3.15862976
17Abnormality of macrophages (HP:0004311)3.11722362
18Reticulocytopenia (HP:0001896)3.05564653
19Autoimmune thrombocytopenia (HP:0001973)2.93153105
20Pustule (HP:0200039)2.90327872
21Prolonged bleeding time (HP:0003010)2.86827604
22IgM deficiency (HP:0002850)2.85657968
23Stomatitis (HP:0010280)2.84504680
24Epistaxis (HP:0000421)2.82671997
25Recurrent skin infections (HP:0001581)2.70278534
26Reduced antithrombin III activity (HP:0001976)2.69540299
27Chronic otitis media (HP:0000389)2.68071605
28Joint hemorrhage (HP:0005261)2.62852554
29Generalized aminoaciduria (HP:0002909)2.60426330
30Mediastinal lymphadenopathy (HP:0100721)2.58397261
31Gingival bleeding (HP:0000225)2.55909813
32Abnormal platelet function (HP:0011869)2.55478756
33Impaired platelet aggregation (HP:0003540)2.55478756
34Loss of speech (HP:0002371)2.50544729
35Aplastic anemia (HP:0001915)2.49588777
36Abnormality of T cell physiology (HP:0011840)2.48322628
37Orchitis (HP:0100796)2.47029909
38Abnormality of B cell number (HP:0010975)2.45681934
39Recurrent fungal infections (HP:0002841)2.45493732
40Periodontitis (HP:0000704)2.43838596
41Systemic lupus erythematosus (HP:0002725)2.43373454
42Purpura (HP:0000979)2.43288678
43Amyloidosis (HP:0011034)2.39082460
44Mitochondrial inheritance (HP:0001427)2.38845682
45Hepatocellular necrosis (HP:0001404)2.38513630
46Spontaneous hematomas (HP:0007420)2.36363100
47Panhypogammaglobulinemia (HP:0003139)2.36032500
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34351050
49Nausea (HP:0002018)2.33229455
50Increased intramyocellular lipid droplets (HP:0012240)2.32232866
51Abnormality of the nasal mucosa (HP:0000433)2.32212150
52Increased IgM level (HP:0003496)2.31371182
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.28212378
54Hepatic necrosis (HP:0002605)2.27908904
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27558127
56Vasculitis (HP:0002633)2.25765065
57B lymphocytopenia (HP:0010976)2.22686557
58Hypertensive crisis (HP:0100735)2.22639146
59Increased muscle lipid content (HP:0009058)2.21684369
60Dicarboxylic aciduria (HP:0003215)2.19585081
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19585081
62Microcytic anemia (HP:0001935)2.17851627
63Pulmonary infiltrates (HP:0002113)2.17562057
64Recurrent viral infections (HP:0004429)2.16703142
65Abnormal mitochondria in muscle tissue (HP:0008316)2.16566074
66Cerebral palsy (HP:0100021)2.15213286
67Pallor (HP:0000980)2.15198491
68Urticaria (HP:0001025)2.14558793
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13769264
70Abnormality of polysaccharide metabolism (HP:0011012)2.13769264
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13769264
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12581668
73Type I transferrin isoform profile (HP:0003642)2.12452670
74Menorrhagia (HP:0000132)2.12243773
75Abnormality of the prostate (HP:0008775)2.09770064
76Chronic obstructive pulmonary disease (HP:0006510)2.08969548
77Obstructive lung disease (HP:0006536)2.08969548
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.07357968
79Nasal polyposis (HP:0100582)2.06269898
80Gingivitis (HP:0000230)2.05760252
81Renal Fanconi syndrome (HP:0001994)2.05478606
82Acute necrotizing encephalopathy (HP:0006965)2.05341600
83Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04953402
84Cellulitis (HP:0100658)2.04024432
85Prolonged partial thromboplastin time (HP:0003645)2.03703746
86Increased CSF lactate (HP:0002490)2.02718656
87Mucopolysacchariduria (HP:0008155)2.01337189
88Urinary glycosaminoglycan excretion (HP:0003541)2.01337189
89Abnormality of the intrinsic pathway (HP:0010989)2.00181939
90Increased cerebral lipofuscin (HP:0011813)1.99828757
91Meningitis (HP:0001287)1.99342656
92Abnormal delayed hypersensitivity skin test (HP:0002963)1.99059505
93Recurrent bronchitis (HP:0002837)1.98046856
94Macrocytic anemia (HP:0001972)1.97508464
95Abnormality of fatty-acid metabolism (HP:0004359)1.97445728
96Progressive neurologic deterioration (HP:0002344)1.96822654
97Increased IgE level (HP:0003212)1.93799460
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93716553
99Prostate neoplasm (HP:0100787)1.92425571
100Basal ganglia calcification (HP:0002135)1.92374019
101Chronic diarrhea (HP:0002028)1.91712181
102Poor head control (HP:0002421)1.90487684
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90006613
104Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90006613
105Prolonged neonatal jaundice (HP:0006579)1.89908184
106Disinhibition (HP:0000734)1.89618904
107Retrobulbar optic neuritis (HP:0100654)1.88543936
108Optic neuritis (HP:0100653)1.88543936
109Abnormality of T cells (HP:0002843)1.87822208
110Pulmonary fibrosis (HP:0002206)1.87212383
111Proximal tubulopathy (HP:0000114)1.86746175
112Abnormality of the common coagulation pathway (HP:0010990)1.85517394
113Increased serum ferritin (HP:0003281)1.84693027
114Hypergammaglobulinemia (HP:0010702)1.84185937
115Complement deficiency (HP:0004431)1.82108781
116Gastrointestinal inflammation (HP:0004386)1.81887424
117Hepatosplenomegaly (HP:0001433)1.81265372
118Beaking of vertebral bodies (HP:0004568)1.78775410
119Autoimmune hemolytic anemia (HP:0001890)1.78566220
120Abnormality of pyrimidine metabolism (HP:0004353)1.78549972
121Neutropenia (HP:0001875)1.77875604
122Abnormality of iron homeostasis (HP:0011031)1.76073113
123Skin ulcer (HP:0200042)1.75351875
124Thrombophlebitis (HP:0004418)1.75028017
125Recurrent cutaneous fungal infections (HP:0011370)1.74341528
126Chronic mucocutaneous candidiasis (HP:0002728)1.74341528
127Glomerulonephritis (HP:0000099)1.72995514
128Abnormal protein glycosylation (HP:0012346)1.72852755
129Abnormal glycosylation (HP:0012345)1.72852755
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72852755
131Abnormal protein N-linked glycosylation (HP:0012347)1.72852755
132Arterial thrombosis (HP:0004420)1.70671078
133Hypoglycemic coma (HP:0001325)1.70466001
134Granulocytopenia (HP:0001913)1.70199631
135Dysostosis multiplex (HP:0000943)1.68824087
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68536709
137Skin rash (HP:0000988)1.68383506
138Abnormality of transition element cation homeostasis (HP:0011030)1.68236609
139Encephalitis (HP:0002383)1.68197621
140Hemoptysis (HP:0002105)1.67847502
141Inflammation of the large intestine (HP:0002037)1.67790711
142Erythema (HP:0010783)1.67692296
143Renal cortical cysts (HP:0000803)1.67587842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.64582956
2VRK23.55347867
3NME23.01910411
4MAP4K12.64421787
5ERN12.49910491
6MAP3K142.48390483
7TBK12.42467284
8IRAK32.31514370
9PIM22.29075783
10KIT2.18325298
11TYK22.17583749
12IKBKE2.12625791
13BLK2.11618516
14IRAK42.11558730
15TXK2.09591105
16SCYL22.05343491
17TEC1.96206320
18TGFBR21.91303172
19ZAP701.89828036
20MAP2K31.86849229
21JAK31.86233574
22IKBKB1.83577330
23BCKDK1.82666576
24BTK1.82106895
25FES1.67664306
26MAP3K31.61730357
27TIE11.60975165
28TGFBR11.57114671
29KDR1.56010100
30GRK71.52678580
31NEK91.52523799
32RPS6KA41.51932644
33STK161.45578577
34MST41.42346662
35TAOK31.41538859
36RIPK41.40732604
37BMPR21.40520540
38FLT31.39052486
39LRRK21.34219765
40GRK61.32013488
41MST1R1.25982934
42MUSK1.24706168
43SYK1.19697512
44DAPK11.19362280
45PIM11.19152953
46MAP3K121.16042531
47MATK1.13477500
48ACVR1B1.13215610
49RPS6KB21.12701943
50TNK21.11724750
51MYLK1.10037453
52FGFR41.08696222
53ARAF1.08472813
54PIK3CG1.04641220
55CHUK1.04237489
56LYN1.01255378
57MAP3K111.00860584
58STK100.99781957
59PBK0.98383910
60CSF1R0.97211645
61NUAK10.94296300
62VRK10.90013409
63EIF2AK30.89126081
64JAK10.88310274
65TRPM70.85930810
66ABL20.85863285
67MAPKAPK30.83645156
68NLK0.83303517
69PRKG20.80825623
70PAK40.79799957
71EIF2AK10.78018924
72EIF2AK20.75998545
73JAK20.75513492
74DYRK30.75014194
75ZAK0.74119390
76LCK0.72804296
77TLK10.72320465
78CSK0.72027934
79STK40.70100295
80MAP2K60.68844849
81PRKCQ0.66772791
82HCK0.62345858
83ADRBK20.61842894
84WEE10.59433482
85LIMK10.58335699
86MAP3K10.57986398
87STK240.57221820
88RPS6KA60.56985503
89GRK10.56588407
90CDK60.54610337
91PKN20.54609212
92PRKCD0.52666913
93ILK0.52240476
94PDK20.51750225
95MAP4K20.50062085
96MAPKAPK20.49830844
97EPHA30.48235268
98PLK40.47695632
99EEF2K0.47447188
100FGFR30.47045701
101EPHA20.46572525
102MAPK110.46564031
103CDK80.46480195
104RPS6KC10.46445559
105RPS6KL10.46445559
106CCNB10.44061461
107MAPKAPK50.44009402
108AURKB0.42711700
109RPS6KA50.41739086
110TAOK20.41621378
111MAP2K20.41590152
112ITK0.40735283
113EPHB10.40323623
114MOS0.39782031
115HIPK20.39773251
116TESK10.39541156
117PASK0.39080641
118FGR0.38782363
119ABL10.38656069
120BUB10.38462809
121CDK70.38216602
122YES10.38191745
123GRK50.38000349
124MAP3K50.35984276
125SMG10.33948846
126BMX0.33758924
127DAPK30.33419298
128IGF1R0.32522485
129NME10.30736879
130MAP3K130.30391370
131TAOK10.28863443
132PDK10.28092874
133MAPK150.27628882

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.24211190
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.62555844
3Type I diabetes mellitus_Homo sapiens_hsa049402.48458106
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22858349
5Staphylococcus aureus infection_Homo sapiens_hsa051502.01304790
6Leishmaniasis_Homo sapiens_hsa051401.95025415
7Proteasome_Homo sapiens_hsa030501.81274012
8Other glycan degradation_Homo sapiens_hsa005111.71336222
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71313043
10Oxidative phosphorylation_Homo sapiens_hsa001901.70160323
11Folate biosynthesis_Homo sapiens_hsa007901.69965666
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.67412992
13Legionellosis_Homo sapiens_hsa051341.65824374
14Caffeine metabolism_Homo sapiens_hsa002321.63122493
15DNA replication_Homo sapiens_hsa030301.61536266
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.59318142
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58599030
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58045622
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.53837390
20Viral myocarditis_Homo sapiens_hsa054161.52829703
21Graft-versus-host disease_Homo sapiens_hsa053321.48734749
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46771353
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45845965
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45459368
25Protein export_Homo sapiens_hsa030601.44782319
26Antigen processing and presentation_Homo sapiens_hsa046121.44774052
27Pertussis_Homo sapiens_hsa051331.38047761
28Measles_Homo sapiens_hsa051621.36723330
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35440932
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34672050
31Allograft rejection_Homo sapiens_hsa053301.34661049
32Chemical carcinogenesis_Homo sapiens_hsa052041.34600053
33Malaria_Homo sapiens_hsa051441.30207889
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.29673422
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28264482
36Hematopoietic cell lineage_Homo sapiens_hsa046401.26808781
37Complement and coagulation cascades_Homo sapiens_hsa046101.26775463
38Primary immunodeficiency_Homo sapiens_hsa053401.26273302
39Sulfur relay system_Homo sapiens_hsa041221.25266532
40Pyrimidine metabolism_Homo sapiens_hsa002401.23636237
41Herpes simplex infection_Homo sapiens_hsa051681.22654774
42Parkinsons disease_Homo sapiens_hsa050121.22075210
43Peroxisome_Homo sapiens_hsa041461.17975728
44Selenocompound metabolism_Homo sapiens_hsa004501.17235442
45Glutathione metabolism_Homo sapiens_hsa004801.13785164
46Asthma_Homo sapiens_hsa053101.12874550
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10567515
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10131128
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.07291930
50Base excision repair_Homo sapiens_hsa034101.05778637
51Lysosome_Homo sapiens_hsa041421.04353765
52Histidine metabolism_Homo sapiens_hsa003401.02944230
53Influenza A_Homo sapiens_hsa051641.02463954
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02095661
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01893297
56Osteoclast differentiation_Homo sapiens_hsa043801.01652733
57RNA polymerase_Homo sapiens_hsa030200.99269295
58Pentose phosphate pathway_Homo sapiens_hsa000300.98942934
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98056722
60Retinol metabolism_Homo sapiens_hsa008300.97807282
61Fatty acid degradation_Homo sapiens_hsa000710.94807361
62Tryptophan metabolism_Homo sapiens_hsa003800.94251576
63Fatty acid elongation_Homo sapiens_hsa000620.94090620
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.92891522
65Galactose metabolism_Homo sapiens_hsa000520.89056342
66Apoptosis_Homo sapiens_hsa042100.88590356
67TNF signaling pathway_Homo sapiens_hsa046680.86471041
68Tuberculosis_Homo sapiens_hsa051520.86178100
69Homologous recombination_Homo sapiens_hsa034400.84918435
70Sulfur metabolism_Homo sapiens_hsa009200.83965287
71Toxoplasmosis_Homo sapiens_hsa051450.81486519
72Vitamin digestion and absorption_Homo sapiens_hsa049770.81200103
73Mismatch repair_Homo sapiens_hsa034300.79959001
74Collecting duct acid secretion_Homo sapiens_hsa049660.79618407
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.78041669
76beta-Alanine metabolism_Homo sapiens_hsa004100.77466669
77Starch and sucrose metabolism_Homo sapiens_hsa005000.76344795
78Huntingtons disease_Homo sapiens_hsa050160.75859972
79Rheumatoid arthritis_Homo sapiens_hsa053230.74928240
80Arachidonic acid metabolism_Homo sapiens_hsa005900.74911346
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74794059
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74558905
83* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74185924
84Systemic lupus erythematosus_Homo sapiens_hsa053220.73144710
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.72855687
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72574460
87Renin-angiotensin system_Homo sapiens_hsa046140.72237877
88Salmonella infection_Homo sapiens_hsa051320.70449799
89Alzheimers disease_Homo sapiens_hsa050100.70404844
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70162896
91One carbon pool by folate_Homo sapiens_hsa006700.70110319
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68300707
93Shigellosis_Homo sapiens_hsa051310.66915558
94B cell receptor signaling pathway_Homo sapiens_hsa046620.66806709
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62792447
96Hepatitis C_Homo sapiens_hsa051600.61129599
97ABC transporters_Homo sapiens_hsa020100.60750380
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60737468
99Fructose and mannose metabolism_Homo sapiens_hsa000510.57573759
100African trypanosomiasis_Homo sapiens_hsa051430.56676201
101Epstein-Barr virus infection_Homo sapiens_hsa051690.55747091
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.55379032
103Nucleotide excision repair_Homo sapiens_hsa034200.54530846
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52949765
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.51552352
106Phagosome_Homo sapiens_hsa041450.51540770
107Hepatitis B_Homo sapiens_hsa051610.50769355
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50456502
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.49887897
110Tyrosine metabolism_Homo sapiens_hsa003500.49717061
111p53 signaling pathway_Homo sapiens_hsa041150.49650776
112Phenylalanine metabolism_Homo sapiens_hsa003600.49423320
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48647194
114Autoimmune thyroid disease_Homo sapiens_hsa053200.47400299
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46892920
116Mineral absorption_Homo sapiens_hsa049780.46753359
117N-Glycan biosynthesis_Homo sapiens_hsa005100.46705399
118Acute myeloid leukemia_Homo sapiens_hsa052210.44588418
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43437205
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42991311
121PPAR signaling pathway_Homo sapiens_hsa033200.41637238
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38111592
123Metabolic pathways_Homo sapiens_hsa011000.34112514
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33886593

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