VANGL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.04866689
2COPI coating of Golgi vesicle (GO:0048205)4.77828188
3Golgi transport vesicle coating (GO:0048200)4.77828188
4mitotic chromosome condensation (GO:0007076)4.27519592
5paraxial mesoderm development (GO:0048339)4.26461342
6regulation of posttranscriptional gene silencing (GO:0060147)4.21038863
7regulation of gene silencing by miRNA (GO:0060964)4.21038863
8regulation of gene silencing by RNA (GO:0060966)4.21038863
9regulation of nuclear cell cycle DNA replication (GO:0033262)4.05750334
10DNA unwinding involved in DNA replication (GO:0006268)3.86477322
11embryonic camera-type eye development (GO:0031076)3.72529473
12nuclear pore complex assembly (GO:0051292)3.71262839
13nuclear pore organization (GO:0006999)3.50838508
14lateral sprouting from an epithelium (GO:0060601)3.49488548
15notochord development (GO:0030903)3.44844627
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44232060
17protein K6-linked ubiquitination (GO:0085020)3.42585630
18mitotic sister chromatid segregation (GO:0000070)3.30907934
19cellular protein complex localization (GO:0034629)3.26603759
20cell-substrate junction assembly (GO:0007044)3.26017555
21negative regulation of androgen receptor signaling pathway (GO:0060766)3.22359533
22regulation of helicase activity (GO:0051095)3.22040336
23protein localization to chromosome, centromeric region (GO:0071459)3.20246937
24protein retention in ER lumen (GO:0006621)3.19289748
25proline biosynthetic process (GO:0006561)3.16614463
26sister chromatid segregation (GO:0000819)3.12323722
27regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.12133115
28pore complex assembly (GO:0046931)3.10910687
29establishment of apical/basal cell polarity (GO:0035089)3.09578896
30anterior/posterior axis specification, embryo (GO:0008595)3.07167455
31proteasome assembly (GO:0043248)3.05065854
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.02404543
33DNA replication initiation (GO:0006270)3.01485012
34mitotic sister chromatid cohesion (GO:0007064)2.98951650
35regulation of mitotic spindle organization (GO:0060236)2.98399696
36regulation of centriole replication (GO:0046599)2.95982606
37cardiac right ventricle morphogenesis (GO:0003215)2.95252976
38maternal placenta development (GO:0001893)2.95171650
39skin morphogenesis (GO:0043589)2.92843491
40regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92406033
41regulation of hippo signaling (GO:0035330)2.91373865
42glomerulus development (GO:0032835)2.91234670
43establishment of integrated proviral latency (GO:0075713)2.91233500
44epithelial cell-cell adhesion (GO:0090136)2.88825719
45focal adhesion assembly (GO:0048041)2.88439270
46cell-substrate adherens junction assembly (GO:0007045)2.88439270
47chromosome condensation (GO:0030261)2.88351858
48negative regulation of chondrocyte differentiation (GO:0032331)2.87415559
49regulation of translational fidelity (GO:0006450)2.85207262
50regulation of spindle organization (GO:0090224)2.84636827
51adherens junction assembly (GO:0034333)2.84128767
52regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.82639453
53cell adhesion mediated by integrin (GO:0033627)2.78730662
54ribosome assembly (GO:0042255)2.78589243
55regulation of water loss via skin (GO:0033561)2.76933647
56DNA strand elongation (GO:0022616)2.76789253
57positive regulation of DNA-dependent DNA replication (GO:2000105)2.75695623
58protein maturation by protein folding (GO:0022417)2.75117797
59kinetochore assembly (GO:0051382)2.73751760
60protein localization to kinetochore (GO:0034501)2.73365301
61protein complex localization (GO:0031503)2.72396113
62DNA strand elongation involved in DNA replication (GO:0006271)2.70924321
63protein localization to microtubule (GO:0035372)2.70199209
64regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.68268608
65retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68130117
66nucleobase-containing small molecule interconversion (GO:0015949)2.67776813
67protein localization to endosome (GO:0036010)2.66436617
68COPII vesicle coating (GO:0048208)2.64380515
69otic vesicle formation (GO:0030916)2.61696702
70positive regulation of SMAD protein import into nucleus (GO:0060391)2.61024337
71regulation of development, heterochronic (GO:0040034)2.60202266
72establishment of monopolar cell polarity (GO:0061162)2.58929130
73establishment or maintenance of monopolar cell polarity (GO:0061339)2.58929130
74peptidyl-proline hydroxylation (GO:0019511)2.58868770
75mitotic nuclear envelope disassembly (GO:0007077)2.58651571
76establishment of chromosome localization (GO:0051303)2.57365665
77positive regulation of epidermal cell differentiation (GO:0045606)2.57346877
78regulation of telomere maintenance via telomerase (GO:0032210)2.57026166
79positive regulation of keratinocyte differentiation (GO:0045618)2.56957114
80formation of translation preinitiation complex (GO:0001731)2.56947351
81regulation of cardioblast differentiation (GO:0051890)2.56713766
82mesenchymal cell proliferation (GO:0010463)2.56475388
83regulation of mesoderm development (GO:2000380)2.56080596
84DNA replication checkpoint (GO:0000076)2.55992849
85nuclear envelope reassembly (GO:0031468)2.55483335
86mitotic nuclear envelope reassembly (GO:0007084)2.55483335
87kinetochore organization (GO:0051383)2.55076856
88DNA duplex unwinding (GO:0032508)2.54882833
89axonemal dynein complex assembly (GO:0070286)2.54756819
90nucleotide-sugar biosynthetic process (GO:0009226)2.54513845
91regulation of SMAD protein import into nucleus (GO:0060390)2.54453204
92mitotic cytokinesis (GO:0000281)2.53336454
93regulation of timing of cell differentiation (GO:0048505)2.53119028
94atrioventricular valve morphogenesis (GO:0003181)2.52489334
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.52138468
96mitotic metaphase plate congression (GO:0007080)2.51799319
97gap junction assembly (GO:0016264)2.51740442
98activation of Rac GTPase activity (GO:0032863)2.51623345
99cranial suture morphogenesis (GO:0060363)2.51562427
100cilium movement (GO:0003341)2.51171515
101mesodermal cell differentiation (GO:0048333)2.50946237
102negative regulation of DNA repair (GO:0045738)2.50746581
103folic acid-containing compound biosynthetic process (GO:0009396)2.50428211
104DNA double-strand break processing (GO:0000729)2.49355145
105DNA damage response, detection of DNA damage (GO:0042769)2.48788086
106ganglion development (GO:0061548)2.48618962
107branching involved in mammary gland duct morphogenesis (GO:0060444)2.48100945
108trophoblast giant cell differentiation (GO:0060707)2.47172226
109negative regulation of keratinocyte proliferation (GO:0010839)2.46882270
110cell surface receptor signaling pathway involved in heart development (GO:0061311)2.46807093
111heterochromatin organization (GO:0070828)2.46644362
112IMP biosynthetic process (GO:0006188)2.46244664
113hippo signaling (GO:0035329)2.45959760
114regulation of transforming growth factor beta2 production (GO:0032909)2.45787292
115DNA packaging (GO:0006323)2.44814875
116nuclear envelope disassembly (GO:0051081)2.44688677
117membrane disassembly (GO:0030397)2.44688677
118synapsis (GO:0007129)2.43498055
119ventricular cardiac muscle cell development (GO:0055015)2.42530823
120transcription from RNA polymerase I promoter (GO:0006360)2.41121531
121positive regulation of Cdc42 GTPase activity (GO:0043089)2.41038622
122DNA geometric change (GO:0032392)2.40352677
123response to folic acid (GO:0051593)2.39651285
124regulation of glomerular filtration (GO:0003093)2.38887036
125maturation of 5.8S rRNA (GO:0000460)2.38782112
126mesonephros development (GO:0001823)2.38439524
127pentose-phosphate shunt (GO:0006098)2.36310272
128negative regulation of cell fate specification (GO:0009996)2.35995152
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34534635
130hemidesmosome assembly (GO:0031581)2.33926963
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.33839605
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.33839605
133muscle cell migration (GO:0014812)2.33105093
134DNA conformation change (GO:0071103)2.32887800
135G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32835924
136glomerular basement membrane development (GO:0032836)2.32087264
137protein hydroxylation (GO:0018126)2.31932391
138regulation of translational termination (GO:0006449)2.31818061
139telomere maintenance via telomerase (GO:0007004)2.31467666
140telomere maintenance via semi-conservative replication (GO:0032201)2.31213503
141termination of RNA polymerase I transcription (GO:0006363)2.30493804
142regulation of double-strand break repair via homologous recombination (GO:0010569)2.29825314
143cell fate commitment involved in formation of primary germ layer (GO:0060795)2.29492918
144lung-associated mesenchyme development (GO:0060484)2.29159000
145ribosome biogenesis (GO:0042254)2.28977862
146cellular response to epidermal growth factor stimulus (GO:0071364)2.28676863
147bone trabecula formation (GO:0060346)2.28145028
148ribosomal large subunit biogenesis (GO:0042273)2.27705306
149vesicle coating (GO:0006901)2.27385174
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.27381230
151regulation of sister chromatid cohesion (GO:0007063)2.27192385
152regulation of apoptotic process involved in morphogenesis (GO:1902337)2.27047385
153bundle of His cell to Purkinje myocyte communication (GO:0086069)2.26498591
154limb bud formation (GO:0060174)2.26039907
155morphogenesis of embryonic epithelium (GO:0016331)2.25786883
156metaphase plate congression (GO:0051310)2.25512722
157positive regulation of chromosome segregation (GO:0051984)2.25155447
158planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24636289
159epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.23254362
160establishment of viral latency (GO:0019043)2.22962426
161telomere maintenance via telomere lengthening (GO:0010833)2.22722683
162mitotic G1 DNA damage checkpoint (GO:0031571)2.22185436
163regulation of gene silencing (GO:0060968)2.21446103
164determination of adult lifespan (GO:0008340)2.21259944
165mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.21243074
166cell migration involved in gastrulation (GO:0042074)2.20815786
167ribonucleoprotein complex biogenesis (GO:0022613)2.20531539
168mesenchymal cell differentiation involved in kidney development (GO:0072161)2.19023751
169mesenchymal cell differentiation involved in renal system development (GO:2001012)2.19023751
170pituitary gland development (GO:0021983)2.18411793
171negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.16956306
172rRNA modification (GO:0000154)2.16880800
173polarized epithelial cell differentiation (GO:0030859)2.15260373
174DNA integration (GO:0015074)2.15145510
175mesenchymal to epithelial transition (GO:0060231)2.14656985
176spindle checkpoint (GO:0031577)2.14485140
177negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.14280678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13920352
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.86669918
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.86669918
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.86669918
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.85516291
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32036940
7TCF3_18692474_ChIP-Seq_MEFs_Mouse2.85852126
8ZNF263_19887448_ChIP-Seq_K562_Human2.84728287
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.81290529
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77378778
11* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.73385017
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.73108600
13* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.63629663
14SOX2_18555785_ChIP-Seq_MESCs_Mouse2.61525620
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.52027628
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51713166
17* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50013470
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.48194016
19* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.46617354
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.43088353
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39614541
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38674467
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35660071
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34191809
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.33691855
26POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.29738410
27* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21420656
28* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.18415831
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.17998237
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07456333
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.06212248
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.05462368
33ESR1_21235772_ChIP-Seq_MCF-7_Human2.04410233
34CLOCK_20551151_ChIP-Seq_293T_Human1.93357963
35* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91464641
36KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.86124632
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86088597
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85881347
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84647692
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84434391
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.82837570
42SOX2_18692474_ChIP-Seq_MEFs_Mouse1.82825453
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82569262
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81000307
45NANOG_18692474_ChIP-Seq_MEFs_Mouse1.79549669
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.79203854
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77730503
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74708542
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73713323
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72582221
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72022740
52RACK7_27058665_Chip-Seq_MCF-7_Human1.71900582
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69533696
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.68301489
55IRF1_19129219_ChIP-ChIP_H3396_Human1.66057535
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65264364
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65264364
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.64608845
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64203621
60POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61649253
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.60699147
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59047889
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58284444
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58054888
65* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.56916045
66DCP1A_22483619_ChIP-Seq_HELA_Human1.55596656
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55406948
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52803994
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51780855
70ATF3_27146783_Chip-Seq_COLON_Human1.51617578
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.51491932
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50609535
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49947376
74* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48592603
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48455911
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46462779
77* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.46298502
78SOX2_18692474_ChIP-Seq_MESCs_Mouse1.45748300
79AR_21909140_ChIP-Seq_LNCAP_Human1.44132019
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.43908915
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.43539972
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42912702
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41748257
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40075828
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36886693
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.35459470
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.35448365
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.35151719
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33570905
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31709241
91CHD1_26751641_Chip-Seq_LNCaP_Human1.30466625
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30128613
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29852239
94ELK1_19687146_ChIP-ChIP_HELA_Human1.27928957
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.26499908
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25804226
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.24774066
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24668902
99OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24206839
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23234887
101UBF1/2_26484160_Chip-Seq_HMECs_Human1.23232560
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22627388
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22112463
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20358155
105MYC_22102868_ChIP-Seq_BL_Human1.19148298
106* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18919627
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17869849
108* SOX17_20123909_ChIP-Seq_XEN_Mouse1.17274048
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17165286
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16538644
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15889318
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.15884425
113* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13911724
114GATA6_25053715_ChIP-Seq_YYC3_Human1.13883389
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13830603
116NANOG_21062744_ChIP-ChIP_HESCs_Human1.13218234
117YY1_21170310_ChIP-Seq_MESCs_Mouse1.12964224
118* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12463135
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12126579
120POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12103887
121* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11672448
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10980627
123NANOG_16518401_ChIP-PET_MESCs_Mouse1.10885571
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09434392
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08963869
126* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08457177
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07897979
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07561643
129SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07131094
130MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06644320
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05866698
132KAP1_27257070_Chip-Seq_ESCs_Mouse1.05661214
133GATA3_24758297_ChIP-Seq_MCF-7_Human1.04827065
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03988356
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03119628
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03003535
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00800158
138* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00652181
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99372724
140* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98656284
141KDM5A_27292631_Chip-Seq_BREAST_Human0.98496376
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98393764
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98291802
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97354301
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95398460
146TFEB_21752829_ChIP-Seq_HELA_Human0.94643407
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94345864
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94004827
149TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93870660
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91080923
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.91078906
152GABP_19822575_ChIP-Seq_HepG2_Human0.90796131
153XRN2_22483619_ChIP-Seq_HELA_Human0.90777742
154* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90059098
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87289807
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.85948087
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84993492
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84694827
159TTF2_22483619_ChIP-Seq_HELA_Human0.84645503
160FLI1_27457419_Chip-Seq_LIVER_Mouse0.75903904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.14941031
2MP0003136_yellow_coat_color3.50962272
3MP0002877_abnormal_melanocyte_morpholog2.90381986
4MP0010234_abnormal_vibrissa_follicle2.75557270
5MP0004272_abnormal_basement_membrane2.74095557
6MP0010030_abnormal_orbit_morphology2.71154940
7MP0000566_synostosis2.66786250
8MP0005623_abnormal_meninges_morphology2.27316407
9MP0000762_abnormal_tongue_morphology2.14507422
10MP0003111_abnormal_nucleus_morphology2.07178361
11MP0004264_abnormal_extraembryonic_tissu2.06782853
12MP0008057_abnormal_DNA_replication2.04737734
13MP0005171_absent_coat_pigmentation2.01544288
14MP0002249_abnormal_larynx_morphology1.98292688
15MP0003937_abnormal_limbs/digits/tail_de1.98123643
16MP0005248_abnormal_Harderian_gland1.95354426
17MP0005076_abnormal_cell_differentiation1.95293721
18* MP0004133_heterotaxia1.91150117
19MP0008438_abnormal_cutaneous_collagen1.81141084
20MP0000049_abnormal_middle_ear1.80758948
21* MP0008932_abnormal_embryonic_tissue1.80583242
22MP0009697_abnormal_copulation1.78032012
23MP0004957_abnormal_blastocyst_morpholog1.76475965
24MP0004233_abnormal_muscle_weight1.75792857
25MP0001849_ear_inflammation1.69016120
26MP0002098_abnormal_vibrissa_morphology1.64117102
27MP0003119_abnormal_digestive_system1.63991364
28MP0004185_abnormal_adipocyte_glucose1.62936409
29MP0003950_abnormal_plasma_membrane1.60909615
30MP0010678_abnormal_skin_adnexa1.56072504
31MP0009250_abnormal_appendicular_skeleto1.54376016
32MP0003755_abnormal_palate_morphology1.52863521
33MP0000516_abnormal_urinary_system1.50807634
34MP0005367_renal/urinary_system_phenotyp1.50807634
35MP0005275_abnormal_skin_tensile1.49601730
36MP0005503_abnormal_tendon_morphology1.49332654
37MP0010352_gastrointestinal_tract_polyps1.48918035
38MP0009053_abnormal_anal_canal1.48915131
39MP0008058_abnormal_DNA_repair1.46834891
40MP0003385_abnormal_body_wall1.46047781
41MP0001216_abnormal_epidermal_layer1.46027903
42MP0001730_embryonic_growth_arrest1.45250187
43MP0006292_abnormal_olfactory_placode1.43939277
44MP0002796_impaired_skin_barrier1.43052415
45MP0010094_abnormal_chromosome_stability1.42633617
46MP0003077_abnormal_cell_cycle1.41932513
47MP0005409_darkened_coat_color1.39551058
48MP0005023_abnormal_wound_healing1.38728606
49MP0000537_abnormal_urethra_morphology1.38237741
50MP0001293_anophthalmia1.35435625
51MP0005501_abnormal_skin_physiology1.33066317
52MP0001188_hyperpigmentation1.32583560
53MP0003890_abnormal_embryonic-extraembry1.30724238
54MP0003942_abnormal_urinary_system1.30415007
55MP0001286_abnormal_eye_development1.28857764
56MP0003566_abnormal_cell_adhesion1.25655908
57MP0002127_abnormal_cardiovascular_syste1.24537069
58MP0000428_abnormal_craniofacial_morphol1.24019223
59MP0005508_abnormal_skeleton_morphology1.23287887
60* MP0002111_abnormal_tail_morphology1.23136755
61MP0000579_abnormal_nail_morphology1.22063726
62MP0003718_maternal_effect1.21618270
63MP0002080_prenatal_lethality1.20896308
64MP0009379_abnormal_foot_pigmentation1.20828127
65MP0003693_abnormal_embryo_hatching1.20019197
66MP0004197_abnormal_fetal_growth/weight/1.19440677
67MP0002060_abnormal_skin_morphology1.19120968
68MP0000432_abnormal_head_morphology1.19018301
69MP0000627_abnormal_mammary_gland1.18655288
70MP0002697_abnormal_eye_size1.18264735
71MP0002938_white_spotting1.18012368
72MP0003878_abnormal_ear_physiology1.17680801
73MP0005377_hearing/vestibular/ear_phenot1.17680801
74MP0002277_abnormal_respiratory_mucosa1.17002422
75MP0001697_abnormal_embryo_size1.16619567
76MP0000534_abnormal_ureter_morphology1.16490583
77MP0003191_abnormal_cellular_cholesterol1.15602578
78MP0000377_abnormal_hair_follicle1.14082199
79MP0008007_abnormal_cellular_replicative1.13650004
80* MP0002085_abnormal_embryonic_tissue1.13511619
81MP0009780_abnormal_chondrocyte_physiolo1.12564532
82MP0010771_integument_phenotype1.12104962
83MP0009384_cardiac_valve_regurgitation1.12023944
84MP0000467_abnormal_esophagus_morphology1.11640310
85MP0002282_abnormal_trachea_morphology1.11614121
86MP0000613_abnormal_salivary_gland1.10056015
87MP0002653_abnormal_ependyma_morphology1.09813344
88MP0003828_pulmonary_edema1.07397682
89MP0003935_abnormal_craniofacial_develop1.06276122
90MP0005408_hypopigmentation1.06207903
91MP0010368_abnormal_lymphatic_system1.05939468
92MP0002233_abnormal_nose_morphology1.05637449
93MP0003936_abnormal_reproductive_system1.05610287
94MP0003938_abnormal_ear_development1.05524333
95MP0002396_abnormal_hematopoietic_system1.05465231
96MP0005380_embryogenesis_phenotype1.05463677
97MP0001672_abnormal_embryogenesis/_devel1.05463677
98* MP0002084_abnormal_developmental_patter1.03505401
99MP0003091_abnormal_cell_migration1.03495699
100MP0002177_abnormal_outer_ear1.03425857
101MP0000647_abnormal_sebaceous_gland1.02775200
102MP0009672_abnormal_birth_weight1.02326784
103MP0005257_abnormal_intraocular_pressure1.02256579
104MP0000383_abnormal_hair_follicle1.02077128
105MP0003786_premature_aging1.01714375
106MP0004381_abnormal_hair_follicle1.01004461
107MP0002254_reproductive_system_inflammat1.00733489
108MP0002932_abnormal_joint_morphology1.00538483
109MP0001661_extended_life_span1.00520985
110MP0001346_abnormal_lacrimal_gland0.98743579
111MP0002086_abnormal_extraembryonic_tissu0.96558206
112MP0000462_abnormal_digestive_system0.96404757
113MP0002116_abnormal_craniofacial_bone0.96354584
114MP0004147_increased_porphyrin_level0.95690009
115MP0003567_abnormal_fetal_cardiomyocyte0.93963970
116MP0005197_abnormal_uvea_morphology0.93367771
117MP0005621_abnormal_cell_physiology0.92954298
118MP0010307_abnormal_tumor_latency0.92917564
119MP0004782_abnormal_surfactant_physiolog0.92639901
120MP0003806_abnormal_nucleotide_metabolis0.91732920
121MP0003705_abnormal_hypodermis_morpholog0.91260742
122MP0000733_abnormal_muscle_development0.90272718
123MP0001485_abnormal_pinna_reflex0.89694351
124MP0003453_abnormal_keratinocyte_physiol0.89431273
125MP0005083_abnormal_biliary_tract0.89366327
126MP0003115_abnormal_respiratory_system0.88811251
127MP0003121_genomic_imprinting0.88719691
128MP0003984_embryonic_growth_retardation0.88370599
129MP0001881_abnormal_mammary_gland0.87682880
130MP0009931_abnormal_skin_appearance0.87384460
131MP0001243_abnormal_dermal_layer0.86685742
132MP0002088_abnormal_embryonic_growth/wei0.86545823
133MP0000350_abnormal_cell_proliferation0.85042414
134MP0005389_reproductive_system_phenotype0.84517713
135MP0002160_abnormal_reproductive_system0.84310655
136MP0003315_abnormal_perineum_morphology0.83337459
137MP0002896_abnormal_bone_mineralization0.83219505
138MP0001915_intracranial_hemorrhage0.77217981
139MP0002092_abnormal_eye_morphology0.76929819
140MP0003943_abnormal_hepatobiliary_system0.74628822
141MP0005384_cellular_phenotype0.73271687
142MP0005451_abnormal_body_composition0.73000100
143MP0001340_abnormal_eyelid_morphology0.72808222
144MP0000358_abnormal_cell_content/0.72558178
145MP0000767_abnormal_smooth_muscle0.71219815
146MP0010630_abnormal_cardiac_muscle0.70724249

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.81118550
2Adrenal hypoplasia (HP:0000835)3.52347098
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37456926
4Hypochromic microcytic anemia (HP:0004840)3.22945483
5Abnormality of the distal phalanges of the toes (HP:0010182)3.14922572
6Microglossia (HP:0000171)3.10046287
7Chromsome breakage (HP:0040012)3.06450464
8Short nail (HP:0001799)3.04751060
9High anterior hairline (HP:0009890)3.01581244
10Protrusio acetabuli (HP:0003179)3.00622010
11Osteolytic defects of the hand bones (HP:0009699)2.99880543
12Osteolytic defects of the phalanges of the hand (HP:0009771)2.99880543
13Curly hair (HP:0002212)2.96534230
14Breast hypoplasia (HP:0003187)2.91868080
15Asymmetry of the thorax (HP:0001555)2.84107675
16Absent radius (HP:0003974)2.82534675
17Bell-shaped thorax (HP:0001591)2.69777005
18Occipital encephalocele (HP:0002085)2.69038043
19Hyperacusis (HP:0010780)2.67482941
20Absent forearm bone (HP:0003953)2.67265893
21Aplasia involving forearm bones (HP:0009822)2.67265893
22Onycholysis (HP:0001806)2.67111210
23Flat acetabular roof (HP:0003180)2.66854946
24Fragile skin (HP:0001030)2.59255698
25Supernumerary spleens (HP:0009799)2.58632872
26Deviation of the thumb (HP:0009603)2.56915209
27Ankyloglossia (HP:0010296)2.52470539
28Shawl scrotum (HP:0000049)2.50683351
29Duplicated collecting system (HP:0000081)2.50064109
30Vertebral compression fractures (HP:0002953)2.49448576
31Broad face (HP:0000283)2.48656378
32Premature rupture of membranes (HP:0001788)2.47150707
33Anophthalmia (HP:0000528)2.44216985
34Colon cancer (HP:0003003)2.43448438
35Trismus (HP:0000211)2.43359730
36Medulloblastoma (HP:0002885)2.39524932
37Ulnar bowing (HP:0003031)2.39129374
38Abnormal respiratory motile cilium physiology (HP:0012261)2.38169109
39Syringomyelia (HP:0003396)2.37642566
40Spinal cord lesions (HP:0100561)2.37642566
41Supernumerary bones of the axial skeleton (HP:0009144)2.37639565
42Esophageal atresia (HP:0002032)2.36335187
43Abnormality of oral frenula (HP:0000190)2.34212280
44Pterygium (HP:0001059)2.34140934
45Supernumerary ribs (HP:0005815)2.32805317
46Proximal placement of thumb (HP:0009623)2.27636978
47Fused cervical vertebrae (HP:0002949)2.27200163
48Septo-optic dysplasia (HP:0100842)2.25000765
49Absent frontal sinuses (HP:0002688)2.24319555
50Arterial tortuosity (HP:0005116)2.23803136
51Concave nail (HP:0001598)2.23731301
52Osteomalacia (HP:0002749)2.23666310
53Rib fusion (HP:0000902)2.22434980
54Abnormal hemoglobin (HP:0011902)2.22237377
55Stomach cancer (HP:0012126)2.21264283
56Natal tooth (HP:0000695)2.20775227
57Ankle contracture (HP:0006466)2.19288766
58Abnormality of the renal collecting system (HP:0004742)2.18369887
59Aplasia/hypoplasia of the humerus (HP:0006507)2.17748725
60* Abnormality of the umbilical cord (HP:0010881)2.16878763
61Meckel diverticulum (HP:0002245)2.15991001
62Parakeratosis (HP:0001036)2.15988306
63Partial duplication of thumb phalanx (HP:0009944)2.15057945
64Abnormality of nail color (HP:0100643)2.14800160
65Septate vagina (HP:0001153)2.14516968
66Abnormality of dentin (HP:0010299)2.14296135
67Fragile nails (HP:0001808)2.11908224
68Abnormality of carpal bone ossification (HP:0006257)2.09589524
69Abnormality of the ileum (HP:0001549)2.09286893
70Selective tooth agenesis (HP:0001592)2.08085031
71Abnormal ciliary motility (HP:0012262)2.08011478
72Cervical subluxation (HP:0003308)2.07991957
73Spinal cord compression (HP:0002176)2.07693724
74Advanced eruption of teeth (HP:0006288)2.07435789
75Sex reversal (HP:0012245)2.07409237
76Abnormal sex determination (HP:0012244)2.07409237
77Atrophic scars (HP:0001075)2.07397757
78Absent hand (HP:0004050)2.07163426
79Insidious onset (HP:0003587)2.06479167
80Termporal pattern (HP:0011008)2.06479167
81Elbow flexion contracture (HP:0002987)2.05526459
82Neoplasm of the oral cavity (HP:0100649)2.03835561
83Abnormality of abdominal situs (HP:0011620)2.03720894
84Abdominal situs inversus (HP:0003363)2.03720894
85Vascular tortuosity (HP:0004948)2.03302781
86Partial duplication of the phalanx of hand (HP:0009999)2.02639126
87Astrocytoma (HP:0009592)2.02223796
88Abnormality of the astrocytes (HP:0100707)2.02223796
89Hepatoblastoma (HP:0002884)2.00873645
90Deep philtrum (HP:0002002)2.00451443
91Distal lower limb muscle weakness (HP:0009053)2.00050094
92Duplication of thumb phalanx (HP:0009942)1.99829235
93Milia (HP:0001056)1.99391019
94Short humerus (HP:0005792)1.99280892
95Pili torti (HP:0003777)1.98457853
96Rectal fistula (HP:0100590)1.98293864
97Rectovaginal fistula (HP:0000143)1.98293864
98Gastrointestinal atresia (HP:0002589)1.98291359
99Insomnia (HP:0100785)1.97708932
100Abnormal ossification of hand bones (HP:0005921)1.97362300
101Glioma (HP:0009733)1.94932069
102Abnormality of the heme biosynthetic pathway (HP:0010472)1.94319426
103Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92599433
104Depressed nasal tip (HP:0000437)1.91910651
105Wormian bones (HP:0002645)1.91238573
106Abnormality of the distal phalanx of the thumb (HP:0009617)1.91093014
107Preaxial foot polydactyly (HP:0001841)1.90909600
108Spinal rigidity (HP:0003306)1.90418177
109Absent thumb (HP:0009777)1.89431366
110Abnormality of the labia minora (HP:0012880)1.89295683
111Increased nuchal translucency (HP:0010880)1.88906509
112Cardiovascular calcification (HP:0011915)1.87265458
113Ectopic kidney (HP:0000086)1.86894028
114Micronodular cirrhosis (HP:0001413)1.86833459
115Embryonal renal neoplasm (HP:0011794)1.85951690
116Sparse eyelashes (HP:0000653)1.85951460
117Nail dystrophy (HP:0008404)1.85928985
118Reduced subcutaneous adipose tissue (HP:0003758)1.85893030
119Aplasia cutis congenita (HP:0001057)1.85887888
120Right ventricular cardiomyopathy (HP:0011663)1.84590574
121Nephroblastoma (Wilms tumor) (HP:0002667)1.84394221
122Hemivertebrae (HP:0002937)1.83211855
123Ridged nail (HP:0001807)1.82542334
124Birth length less than 3rd percentile (HP:0003561)1.81452755
125Aortic dissection (HP:0002647)1.81045769
126Abnormality of the preputium (HP:0100587)1.80477734
127Shallow orbits (HP:0000586)1.80269364
128Facial cleft (HP:0002006)1.80246982
129Abnormality of the acetabulum (HP:0003170)1.80114681
130Triphalangeal thumb (HP:0001199)1.79453082
131* Abnormalities of placenta or umbilical cord (HP:0001194)1.78905479
132Blue sclerae (HP:0000592)1.78273008
133Vascular calcification (HP:0004934)1.77659644
134Ureteral duplication (HP:0000073)1.77381122
135Upper limb muscle weakness (HP:0003484)1.77170536
136Nasolacrimal duct obstruction (HP:0000579)1.76494087
137Atelectasis (HP:0100750)1.76491495
138Abnormality of the lacrimal duct (HP:0011481)1.76369877
139Abnormality of the incisor (HP:0000676)1.76248794
140Long palpebral fissure (HP:0000637)1.75987517
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.75704432
142Bladder diverticulum (HP:0000015)1.74460819
143Alopecia of scalp (HP:0002293)1.74309027
144Distal lower limb amyotrophy (HP:0008944)1.73176960
145Missing ribs (HP:0000921)1.72403441
146Delayed cranial suture closure (HP:0000270)1.71815238
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70676255
148Reticulocytopenia (HP:0001896)1.70544910
149Achilles tendon contracture (HP:0001771)1.69210970
150Aplasia involving bones of the extremities (HP:0009825)1.68780055
151Aplasia involving bones of the upper limbs (HP:0009823)1.68780055
152Aplasia of the phalanges of the hand (HP:0009802)1.68780055
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.68450726
154* Abnormal ventriculo-arterial connection (HP:0011563)1.67919861
155* Transposition of the great arteries (HP:0001669)1.67919861
156* Abnormal connection of the cardiac segments (HP:0011545)1.67919861
157Neonatal short-limb short stature (HP:0008921)1.67593294
158Conical tooth (HP:0000698)1.67201761
159Aplasia of the musculature (HP:0100854)1.66733074
160Sparse lateral eyebrow (HP:0005338)1.66587368
161Aplasia/Hypoplasia of the ulna (HP:0006495)1.66515574
162Abnormality of the nasolacrimal system (HP:0000614)1.64703702
163Increased connective tissue (HP:0009025)1.64506283
164Median cleft lip (HP:0000161)1.63775000
165Vertebral arch anomaly (HP:0008438)1.63413629
166Rough bone trabeculation (HP:0100670)1.63078900
167Esophageal varix (HP:0002040)1.62920371
168Distal upper limb amyotrophy (HP:0007149)1.62277271
169Upper limb amyotrophy (HP:0009129)1.62277271
170Renal duplication (HP:0000075)1.61666317
171Coronal craniosynostosis (HP:0004440)1.61422794
172Patellar aplasia (HP:0006443)1.61094023
173Plantar hyperkeratosis (HP:0007556)1.61052928
174Tubulointerstitial nephritis (HP:0001970)1.60830992
175Lip pit (HP:0100267)1.60185229
176* Abnormality of the fetal cardiovascular system (HP:0010948)1.60090804
177* Abnormal umbilical cord blood vessels (HP:0011403)1.60090804
178* Single umbilical artery (HP:0001195)1.60090804
179Progressive muscle weakness (HP:0003323)1.59909643
180Abnormality of the phalanges of the hallux (HP:0010057)1.59825206
181Absent eyelashes (HP:0000561)1.58787818
182Patellar dislocation (HP:0002999)1.58457406
183Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56174947
184Entropion (HP:0000621)1.55902639
185Abnormal foot bone ossification (HP:0010675)1.54044245
186Abnormality of the frontal sinuses (HP:0002687)1.53631794
187Abnormal hand bone ossification (HP:0010660)1.53345442
188Abnormality of the gastric mucosa (HP:0004295)1.52978280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.30890547
2ICK3.70158276
3ZAK3.48054644
4TRIB33.45087624
5LATS12.94572564
6SMG12.94318528
7SCYL22.84980178
8AKT32.49549756
9MAPK152.43459411
10STK38L2.21913097
11SIK12.11375418
12MKNK22.07963081
13TTK2.05618410
14CDK122.03037898
15BUB11.97276540
16CDK71.94868533
17PKN21.79699710
18MET1.78048150
19MKNK11.75379646
20WEE11.74844169
21SRPK11.72828265
22EEF2K1.72032407
23VRK21.69767536
24PDGFRA1.66169818
25MAP3K121.61065321
26PTK21.60282292
27STK391.55913788
28DDR21.54341968
29NUAK11.51544578
30PLK11.49531466
31NEK11.48227069
32TLK11.48216953
33YES11.40206653
34TESK11.36008576
35DYRK31.35973271
36RPS6KB21.35100712
37CASK1.29532246
38TRPM71.26091986
39TTN1.25129164
40TAF11.24575452
41LATS21.23479196
42PBK1.21957552
43BCR1.21274311
44AURKA1.20795872
45STK161.20163454
46PRPF4B1.19336386
47BRSK11.19162716
48EPHB21.18897684
49CSNK1A1L1.18387635
50GRK11.14303021
51NME21.12286894
52CDK191.08795610
53CHEK21.08759143
54MST41.08527659
55MAP3K101.07616700
56AURKB1.02028247
57MAPKAPK30.99713498
58TIE10.97895412
59STK30.95399090
60PLK30.94065884
61CSNK1G10.93607041
62WNK40.92134072
63FER0.91930871
64ILK0.91051075
65PIM20.89732165
66MAP3K30.89247133
67VRK10.89094328
68PLK40.88604206
69EIF2AK20.88232429
70EIF2AK10.88099476
71CDC70.88036270
72DYRK20.88017564
73LMTK20.87259316
74CSNK1G30.86270261
75STK40.85209626
76PNCK0.84693324
77NEK60.80905723
78IRAK10.79387616
79MAP2K20.79256353
80PRKCI0.76744084
81PINK10.75291159
82MAP3K80.73668611
83LRRK20.72372352
84FLT30.71546070
85ERN10.69951713
86DMPK0.69891136
87NEK20.69627019
88ARAF0.69295416
89BMX0.67435335
90PTK60.67325294
91TESK20.65387477
92RIPK10.65173524
93ERBB30.63812751
94MST1R0.62672148
95CCNB10.62510097
96STK100.61658421
97CAMK1G0.60715517
98ERBB40.60639510
99BRD40.60372854
100LIMK10.60179418
101ATM0.60069844
102CDK60.59817259
103OXSR10.59698415
104CHEK10.59087148
105PIM10.58849440
106CDK90.58603871
107IRAK30.58529107
108KDR0.57531461
109ATR0.57493435
110NTRK10.56937823
111CDK40.56183094
112PAK40.55855963
113WNK10.55572520
114PAK20.55398899
115OBSCN0.53441065
116BRSK20.52842483
117CLK10.52680123
118MTOR0.51870232
119NEK90.50750115
120CSNK2A10.50491632
121AKT20.50338884
122MELK0.50164724
123CAMK1D0.49966663
124CDK30.49087951
125MAP3K60.47301220
126PKN10.46220026
127MUSK0.45416972
128MYLK0.45086022
129PRKD30.44358086
130MAP3K20.44296265
131CDK80.42007040
132CDK20.41567511
133MAPK70.41387350
134SIK30.41114511
135CSNK1D0.40362241
136PAK10.40165768
137BRAF0.40107773
138FGFR40.38633938
139ROCK20.38618533
140CDK10.38479561
141RPS6KA50.38132607
142TAOK20.37748138
143MAP2K10.36966627
144EIF2AK30.35534544
145GSK3A0.35483259
146TSSK60.35449251

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.14103138
2DNA replication_Homo sapiens_hsa030303.03282905
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74241633
4Basal cell carcinoma_Homo sapiens_hsa052172.72974096
5Ribosome_Homo sapiens_hsa030102.62470722
6Fanconi anemia pathway_Homo sapiens_hsa034602.59131414
7RNA polymerase_Homo sapiens_hsa030202.53255070
8Homologous recombination_Homo sapiens_hsa034402.48411656
9Nucleotide excision repair_Homo sapiens_hsa034202.36463484
10One carbon pool by folate_Homo sapiens_hsa006702.21197374
11Base excision repair_Homo sapiens_hsa034102.17936463
12Hippo signaling pathway_Homo sapiens_hsa043902.03686525
13RNA transport_Homo sapiens_hsa030132.02160229
14Spliceosome_Homo sapiens_hsa030402.01381022
15Proteasome_Homo sapiens_hsa030502.00624369
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97262620
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93403412
18Hedgehog signaling pathway_Homo sapiens_hsa043401.91863253
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91849475
20Cell cycle_Homo sapiens_hsa041101.87117605
21Arachidonic acid metabolism_Homo sapiens_hsa005901.81006561
22ECM-receptor interaction_Homo sapiens_hsa045121.78981038
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.76035041
24Pyrimidine metabolism_Homo sapiens_hsa002401.75919073
25Basal transcription factors_Homo sapiens_hsa030221.72530714
26Biosynthesis of amino acids_Homo sapiens_hsa012301.69530022
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69139111
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64798516
29Chronic myeloid leukemia_Homo sapiens_hsa052201.62519778
30Pentose phosphate pathway_Homo sapiens_hsa000301.61502767
31p53 signaling pathway_Homo sapiens_hsa041151.58423658
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55762042
33TGF-beta signaling pathway_Homo sapiens_hsa043501.52249767
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51183767
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45485031
36Glutathione metabolism_Homo sapiens_hsa004801.42450835
37Pancreatic cancer_Homo sapiens_hsa052121.40183547
38Vitamin B6 metabolism_Homo sapiens_hsa007501.37905903
39N-Glycan biosynthesis_Homo sapiens_hsa005101.34549683
40Tight junction_Homo sapiens_hsa045301.32344475
41Sulfur relay system_Homo sapiens_hsa041221.31948837
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28243291
43Non-homologous end-joining_Homo sapiens_hsa034501.26938545
44Adherens junction_Homo sapiens_hsa045201.25469278
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24622282
46mRNA surveillance pathway_Homo sapiens_hsa030151.21403916
47Linoleic acid metabolism_Homo sapiens_hsa005911.20548698
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19918727
49RNA degradation_Homo sapiens_hsa030181.18243878
50Protein export_Homo sapiens_hsa030601.15531332
51Non-small cell lung cancer_Homo sapiens_hsa052231.12562785
52MicroRNAs in cancer_Homo sapiens_hsa052061.09878580
53Galactose metabolism_Homo sapiens_hsa000521.06158456
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04962860
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03742367
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03600160
57Carbon metabolism_Homo sapiens_hsa012001.02994941
58Huntingtons disease_Homo sapiens_hsa050161.00264417
59Vitamin digestion and absorption_Homo sapiens_hsa049770.99573428
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96857441
61Purine metabolism_Homo sapiens_hsa002300.96151246
62Renal cell carcinoma_Homo sapiens_hsa052110.95470106
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.94133219
64Arginine and proline metabolism_Homo sapiens_hsa003300.93659266
65Pathways in cancer_Homo sapiens_hsa052000.92259110
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91936021
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90566808
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89434681
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88817462
70Pyruvate metabolism_Homo sapiens_hsa006200.88233382
71Small cell lung cancer_Homo sapiens_hsa052220.87446068
72Sphingolipid metabolism_Homo sapiens_hsa006000.86427593
73Colorectal cancer_Homo sapiens_hsa052100.86049678
74* Wnt signaling pathway_Homo sapiens_hsa043100.85095271
75Ether lipid metabolism_Homo sapiens_hsa005650.84988457
76Vibrio cholerae infection_Homo sapiens_hsa051100.83923664
77Focal adhesion_Homo sapiens_hsa045100.82881094
78Systemic lupus erythematosus_Homo sapiens_hsa053220.82373917
79Glioma_Homo sapiens_hsa052140.82240469
80Melanoma_Homo sapiens_hsa052180.80350444
81Notch signaling pathway_Homo sapiens_hsa043300.79856373
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79681920
83Acute myeloid leukemia_Homo sapiens_hsa052210.76931829
84Lysine degradation_Homo sapiens_hsa003100.75404426
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75028831
86Prostate cancer_Homo sapiens_hsa052150.74474251
87ErbB signaling pathway_Homo sapiens_hsa040120.73984229
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73615081
89Folate biosynthesis_Homo sapiens_hsa007900.73198802
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73068611
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72814538
92Amoebiasis_Homo sapiens_hsa051460.71038389
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70746642
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70131533
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69568462
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68330530
97Steroid biosynthesis_Homo sapiens_hsa001000.67010822
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.66598734
99Oxidative phosphorylation_Homo sapiens_hsa001900.65513248
100Protein digestion and absorption_Homo sapiens_hsa049740.64435655
101Shigellosis_Homo sapiens_hsa051310.64073237
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63481573
103Bladder cancer_Homo sapiens_hsa052190.62857020
104Sulfur metabolism_Homo sapiens_hsa009200.62777390
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62702718
106Proteoglycans in cancer_Homo sapiens_hsa052050.62009344
107HTLV-I infection_Homo sapiens_hsa051660.60627610
108Mineral absorption_Homo sapiens_hsa049780.60127013
109Insulin signaling pathway_Homo sapiens_hsa049100.59056431
110AMPK signaling pathway_Homo sapiens_hsa041520.59034532
111Selenocompound metabolism_Homo sapiens_hsa004500.58497696
112Chemical carcinogenesis_Homo sapiens_hsa052040.57240270
113Fructose and mannose metabolism_Homo sapiens_hsa000510.57057085
114Malaria_Homo sapiens_hsa051440.57051697
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56621508
116Retinol metabolism_Homo sapiens_hsa008300.55544013
117Apoptosis_Homo sapiens_hsa042100.54957483
118Phenylalanine metabolism_Homo sapiens_hsa003600.54398608
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54073970
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53611993
121Axon guidance_Homo sapiens_hsa043600.53265024
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51956438
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50653383
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50239569
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50084294
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49575064
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49532192
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48054473
129Renin-angiotensin system_Homo sapiens_hsa046140.47908336
130Fatty acid elongation_Homo sapiens_hsa000620.47876199
131Parkinsons disease_Homo sapiens_hsa050120.47429475
132Endometrial cancer_Homo sapiens_hsa052130.46470539
133Metabolic pathways_Homo sapiens_hsa011000.44895849
134Hepatitis B_Homo sapiens_hsa051610.44879809
135Hepatitis C_Homo sapiens_hsa051600.44042961
136Dorso-ventral axis formation_Homo sapiens_hsa043200.43187693
137Other glycan degradation_Homo sapiens_hsa005110.42887540
138Epstein-Barr virus infection_Homo sapiens_hsa051690.42346521
139Viral carcinogenesis_Homo sapiens_hsa052030.39597272
140Autoimmune thyroid disease_Homo sapiens_hsa053200.39468097
141Dilated cardiomyopathy_Homo sapiens_hsa054140.37095079
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35479695
143Thyroid cancer_Homo sapiens_hsa052160.31294783
144Alcoholism_Homo sapiens_hsa050340.26254826
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.26146929
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.24193262

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