VANGL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* lateral sprouting from an epithelium (GO:0060601)5.40613038
2presynaptic membrane organization (GO:0097090)4.73321651
3postsynaptic membrane organization (GO:0001941)4.35253386
4limb bud formation (GO:0060174)4.24112928
5nucleobase catabolic process (GO:0046113)3.83915382
6head development (GO:0060322)3.81920363
7* planar cell polarity pathway involved in neural tube closure (GO:0090179)3.80369449
8central nervous system projection neuron axonogenesis (GO:0021952)3.53181941
9* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.53117242
10axon extension involved in axon guidance (GO:0048846)3.49868765
11neuron projection extension involved in neuron projection guidance (GO:1902284)3.49868765
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.45918903
13cranial nerve morphogenesis (GO:0021602)3.37022016
14cerebral cortex radially oriented cell migration (GO:0021799)3.29469004
15negative regulation of axon extension involved in axon guidance (GO:0048843)3.27964804
16neuronal stem cell maintenance (GO:0097150)3.21812449
17cell migration in hindbrain (GO:0021535)3.20839874
18dendritic spine morphogenesis (GO:0060997)3.20782864
19negative regulation of axon guidance (GO:1902668)3.19473639
20axonal fasciculation (GO:0007413)3.19222891
21central nervous system myelination (GO:0022010)3.17360273
22axon ensheathment in central nervous system (GO:0032291)3.17360273
23paraxial mesoderm development (GO:0048339)3.16399049
24regulation of gene silencing by RNA (GO:0060966)3.16314149
25regulation of posttranscriptional gene silencing (GO:0060147)3.16314149
26regulation of gene silencing by miRNA (GO:0060964)3.16314149
27* establishment of planar polarity (GO:0001736)3.15330944
28* establishment of tissue polarity (GO:0007164)3.15330944
29establishment of nucleus localization (GO:0040023)3.11802881
30regulation of development, heterochronic (GO:0040034)3.11465326
31positive regulation of neuroblast proliferation (GO:0002052)3.11041694
32proximal/distal pattern formation (GO:0009954)3.10475416
33vocalization behavior (GO:0071625)3.05849407
34camera-type eye morphogenesis (GO:0048593)3.00328864
35face development (GO:0060324)2.97317204
36regulation of timing of cell differentiation (GO:0048505)2.96357970
37forebrain neuron differentiation (GO:0021879)2.96048565
38negative regulation of catenin import into nucleus (GO:0035414)2.93735619
39hindlimb morphogenesis (GO:0035137)2.92797094
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.91959428
41hindbrain development (GO:0030902)2.87350878
42negative regulation of oligodendrocyte differentiation (GO:0048715)2.86282927
43* cochlea morphogenesis (GO:0090103)2.84802521
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84076212
45negative regulation of translation, ncRNA-mediated (GO:0040033)2.84076212
46regulation of translation, ncRNA-mediated (GO:0045974)2.84076212
47sympathetic nervous system development (GO:0048485)2.83951720
48regulation of somitogenesis (GO:0014807)2.82410428
49lens fiber cell development (GO:0070307)2.79644775
50establishment of mitochondrion localization (GO:0051654)2.77123376
51neuron cell-cell adhesion (GO:0007158)2.77047539
52cell proliferation in forebrain (GO:0021846)2.76648030
53* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.75056206
54cranial nerve development (GO:0021545)2.74322267
55heterochromatin organization (GO:0070828)2.74127955
56regulation of mesenchymal cell apoptotic process (GO:2001053)2.73835075
57neuron recognition (GO:0008038)2.73432007
58embryonic hindlimb morphogenesis (GO:0035116)2.69060344
59central nervous system neuron axonogenesis (GO:0021955)2.69039701
60dendrite morphogenesis (GO:0048813)2.69036951
61mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.68444490
62pre-miRNA processing (GO:0031054)2.68421526
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67838905
64regulation of cell fate specification (GO:0042659)2.66994247
65nucleosome disassembly (GO:0006337)2.66962856
66protein-DNA complex disassembly (GO:0032986)2.66962856
67eyelid development in camera-type eye (GO:0061029)2.65805345
68cellular response to cholesterol (GO:0071397)2.63751205
69* regulation of establishment of planar polarity (GO:0090175)2.63739595
70* convergent extension (GO:0060026)2.63575243
71regulation of axon extension involved in axon guidance (GO:0048841)2.61720815
72mesenchymal cell proliferation (GO:0010463)2.61174059
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60152768
74* non-canonical Wnt signaling pathway (GO:0035567)2.60126399
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59009875
76regulation of non-canonical Wnt signaling pathway (GO:2000050)2.58641699
77dorsal/ventral axis specification (GO:0009950)2.58342045
78cell fate commitment involved in formation of primary germ layer (GO:0060795)2.57388764
79axon extension (GO:0048675)2.57207561
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57149067
81thalamus development (GO:0021794)2.57031838
82pyrimidine nucleobase catabolic process (GO:0006208)2.55268078
83negative regulation of smoothened signaling pathway (GO:0045879)2.55144062
84calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55101701
85primitive streak formation (GO:0090009)2.54777521
86outer ear morphogenesis (GO:0042473)2.54652261
87negative regulation of mRNA processing (GO:0050686)2.54469300
88regulation of oligodendrocyte differentiation (GO:0048713)2.54465680
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.54196649
90peptidyl-arginine omega-N-methylation (GO:0035247)2.53393076
91mesenchyme morphogenesis (GO:0072132)2.52798074
92positive regulation of gastrulation (GO:2000543)2.51542844
93limb development (GO:0060173)2.51056164
94appendage development (GO:0048736)2.51056164
95tongue development (GO:0043586)2.50641874
96cardiac ventricle formation (GO:0003211)2.50549752
97* cell surface receptor signaling pathway involved in heart development (GO:0061311)2.50354504
98positive regulation of synapse assembly (GO:0051965)2.50221171
99notochord development (GO:0030903)2.49766692
100ionotropic glutamate receptor signaling pathway (GO:0035235)2.49481001
101forebrain development (GO:0030900)2.49210855
102negative regulation of axon extension (GO:0030517)2.48647945
103spinal cord association neuron differentiation (GO:0021527)2.48028903
104pituitary gland development (GO:0021983)2.47867944
105positive regulation of cell cycle G2/M phase transition (GO:1902751)2.47746393
106positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.47746393
107protein localization to synapse (GO:0035418)2.47540933
108negative regulation of RNA splicing (GO:0033119)2.47423944
109lung-associated mesenchyme development (GO:0060484)2.46516195
110ephrin receptor signaling pathway (GO:0048013)2.46328005
111spinal cord development (GO:0021510)2.46118148
112forelimb morphogenesis (GO:0035136)2.45402242
113mRNA splice site selection (GO:0006376)2.44816370
114otic vesicle formation (GO:0030916)2.44193554
115negative regulation of glial cell differentiation (GO:0045686)2.44110223
116regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.44078195
117somite development (GO:0061053)2.43774462
118generation of neurons (GO:0048699)2.43149530
119renal system development (GO:0072001)2.42378351
120dopaminergic neuron differentiation (GO:0071542)2.41973134
121histone arginine methylation (GO:0034969)2.41549482
122endocardial cushion morphogenesis (GO:0003203)2.41177031
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.40583121
124mitochondrion transport along microtubule (GO:0047497)2.40583121
125neuron migration (GO:0001764)2.40203085
126bone trabecula formation (GO:0060346)2.40138667
127synapse assembly (GO:0007416)2.39734210
128transmission of nerve impulse (GO:0019226)2.39145018
129mesenchymal to epithelial transition (GO:0060231)2.38286134
130forebrain neuron development (GO:0021884)2.37913597
131negative regulation of embryonic development (GO:0045992)2.37786330
132regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37726612
133peptidyl-arginine methylation (GO:0018216)2.37699087
134peptidyl-arginine N-methylation (GO:0035246)2.37699087
135ventricular trabecula myocardium morphogenesis (GO:0003222)2.37621708
136regulation of NFAT protein import into nucleus (GO:0051532)2.37381504
137negative regulation of chondrocyte differentiation (GO:0032331)2.37063532
138midbrain development (GO:0030901)2.36707979
139neuron fate commitment (GO:0048663)2.35569821
140retinal ganglion cell axon guidance (GO:0031290)2.35538471
141urogenital system development (GO:0001655)2.35474979
142layer formation in cerebral cortex (GO:0021819)2.35277669
143negative regulation of stem cell proliferation (GO:2000647)2.34894217
144* somatic stem cell division (GO:0048103)2.34879996
145embryonic retina morphogenesis in camera-type eye (GO:0060059)2.34376013
146regulation of axon guidance (GO:1902667)2.33353774
147glial cell proliferation (GO:0014009)2.32864919
148presynaptic membrane assembly (GO:0097105)2.30464196
149negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.30409957
150anterior/posterior axis specification (GO:0009948)2.29563523
151regulation of smoothened signaling pathway (GO:0008589)2.28905377
152cell differentiation in spinal cord (GO:0021515)2.28103613
153embryonic forelimb morphogenesis (GO:0035115)2.27625238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.63400400
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24943974
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.99572332
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.99569627
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.78898391
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.70902919
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.66903616
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57667934
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.56350244
10PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.53754554
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32221059
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26288703
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26288703
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21663182
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20908741
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.20167342
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.19841261
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19145509
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.18201151
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07231044
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.06171220
22RNF2_27304074_Chip-Seq_NSC_Mouse2.01890155
23* RING1B_27294783_Chip-Seq_NPCs_Mouse2.00592437
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95484495
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92864726
26EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90907081
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89526919
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.83345998
29TP53_20018659_ChIP-ChIP_R1E_Mouse1.83255575
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81600880
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78552699
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78031798
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.77881993
34GBX2_23144817_ChIP-Seq_PC3_Human1.75725930
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73309741
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69670463
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.66599284
38* RING1B_27294783_Chip-Seq_ESCs_Mouse1.66446865
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65073196
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65073196
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65073196
42* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62427657
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56432302
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55361079
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51658372
46FUS_26573619_Chip-Seq_HEK293_Human1.51454550
47REST_21632747_ChIP-Seq_MESCs_Mouse1.50836489
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50654464
49IGF1R_20145208_ChIP-Seq_DFB_Human1.50504305
50* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46684913
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42690609
52* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39321831
53AR_21572438_ChIP-Seq_LNCaP_Human1.38627041
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37966557
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37955868
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.36946601
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35672575
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35209303
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33794135
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32700659
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32481736
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.30666075
63EWS_26573619_Chip-Seq_HEK293_Human1.27133470
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26960573
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26960573
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.25602993
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24181005
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24177303
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24070671
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23574063
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22805186
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.21803689
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21387472
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20324739
75POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20139286
76TAF15_26573619_Chip-Seq_HEK293_Human1.19343496
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16647411
78TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16174462
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14240660
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13674398
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13541004
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.13322712
83NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10395165
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09682894
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07797531
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.07387138
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06538399
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.06031088
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05489384
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04334636
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03642000
92PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03629663
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00961343
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00620916
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00033352
96TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99827313
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99394075
98TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98978858
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.98076890
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97978569
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97777535
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97237011
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95033838
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94643068
105SOX9_26525672_Chip-Seq_HEART_Mouse0.93893914
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93094381
107P300_19829295_ChIP-Seq_ESCs_Human0.93057631
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.92347195
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91720478
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90693984
111POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.90220759
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.90045662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.81585990
2MP0010030_abnormal_orbit_morphology3.50431083
3MP0006292_abnormal_olfactory_placode2.70887172
4MP0000537_abnormal_urethra_morphology2.66060818
5* MP0000778_abnormal_nervous_system2.54584491
6MP0000049_abnormal_middle_ear2.54292566
7MP0003941_abnormal_skin_development2.42784416
8MP0008789_abnormal_olfactory_epithelium2.35619459
9MP0002938_white_spotting2.24771273
10MP0004859_abnormal_synaptic_plasticity2.15724020
11MP0002249_abnormal_larynx_morphology2.06302395
12MP0003122_maternal_imprinting2.00416885
13MP0009053_abnormal_anal_canal1.99013432
14MP0003937_abnormal_limbs/digits/tail_de1.98116807
15MP0003283_abnormal_digestive_organ1.95940719
16MP0002653_abnormal_ependyma_morphology1.93915367
17MP0003755_abnormal_palate_morphology1.92967304
18MP0005394_taste/olfaction_phenotype1.91993259
19MP0005499_abnormal_olfactory_system1.91993259
20MP0003890_abnormal_embryonic-extraembry1.91826432
21MP0009250_abnormal_appendicular_skeleto1.83347543
22MP0000383_abnormal_hair_follicle1.80961950
23* MP0003938_abnormal_ear_development1.79746641
24* MP0003385_abnormal_body_wall1.79553518
25MP0003121_genomic_imprinting1.78908040
26MP0000762_abnormal_tongue_morphology1.78776708
27MP0002233_abnormal_nose_morphology1.70467707
28MP0001293_anophthalmia1.65581000
29MP0000428_abnormal_craniofacial_morphol1.64820426
30MP0003136_yellow_coat_color1.64228238
31MP0002102_abnormal_ear_morphology1.62875250
32MP0003935_abnormal_craniofacial_develop1.56382065
33MP0000631_abnormal_neuroendocrine_gland1.56116177
34MP0002116_abnormal_craniofacial_bone1.55949922
35MP0001984_abnormal_olfaction1.54923864
36* MP0003861_abnormal_nervous_system1.54172590
37MP0002282_abnormal_trachea_morphology1.53406989
38MP0002751_abnormal_autonomic_nervous1.53217749
39MP0001346_abnormal_lacrimal_gland1.52728104
40MP0004270_analgesia1.51482934
41MP0001188_hyperpigmentation1.50995176
42MP0003942_abnormal_urinary_system1.50525574
43MP0003878_abnormal_ear_physiology1.44149545
44MP0005377_hearing/vestibular/ear_phenot1.44149545
45MP0002098_abnormal_vibrissa_morphology1.42464165
46MP0010678_abnormal_skin_adnexa1.42452293
47MP0003315_abnormal_perineum_morphology1.42171602
48MP0001286_abnormal_eye_development1.38649035
49* MP0002932_abnormal_joint_morphology1.35050361
50MP0004133_heterotaxia1.31954681
51MP0000432_abnormal_head_morphology1.29309683
52MP0005257_abnormal_intraocular_pressure1.28839002
53* MP0003119_abnormal_digestive_system1.28330879
54MP0002697_abnormal_eye_size1.27846697
55MP0003880_abnormal_central_pattern1.25321782
56MP0003635_abnormal_synaptic_transmissio1.23579318
57MP0003567_abnormal_fetal_cardiomyocyte1.23423211
58MP0009672_abnormal_birth_weight1.22679328
59MP0003787_abnormal_imprinting1.21897195
60MP0000467_abnormal_esophagus_morphology1.21537724
61* MP0000026_abnormal_inner_ear1.20065281
62MP0005423_abnormal_somatic_nervous1.19925606
63MP0004885_abnormal_endolymph1.17742382
64MP0002177_abnormal_outer_ear1.17185373
65MP0005248_abnormal_Harderian_gland1.16933891
66MP0000579_abnormal_nail_morphology1.16797838
67MP0000569_abnormal_digit_pigmentation1.15470921
68MP0000647_abnormal_sebaceous_gland1.14822943
69MP0002063_abnormal_learning/memory/cond1.14366287
70MP0002184_abnormal_innervation1.13770770
71MP0002234_abnormal_pharynx_morphology1.13095303
72MP0002734_abnormal_mechanical_nocicepti1.12226441
73MP0005187_abnormal_penis_morphology1.12011331
74MP0002092_abnormal_eye_morphology1.09607708
75MP0001340_abnormal_eyelid_morphology1.08797574
76MP0003115_abnormal_respiratory_system1.08750589
77MP0002822_catalepsy1.08096147
78MP0002735_abnormal_chemical_nociception1.07934746
79* MP0002081_perinatal_lethality1.04848958
80MP0000534_abnormal_ureter_morphology1.04717372
81MP0005409_darkened_coat_color1.03925382
82MP0001486_abnormal_startle_reflex1.02861606
83MP0000678_abnormal_parathyroid_gland1.02821310
84* MP0002085_abnormal_embryonic_tissue1.02691561
85MP0001177_atelectasis1.02495180
86MP0001485_abnormal_pinna_reflex1.02427394
87MP0004811_abnormal_neuron_physiology1.02237645
88MP0006276_abnormal_autonomic_nervous1.01679672
89* MP0002152_abnormal_brain_morphology1.01364596
90MP0004381_abnormal_hair_follicle1.00964910
91MP0001299_abnormal_eye_distance/1.00861692
92MP0005645_abnormal_hypothalamus_physiol1.00848720
93* MP0002114_abnormal_axial_skeleton1.00317916
94MP0000955_abnormal_spinal_cord0.99883185
95* MP0002084_abnormal_developmental_patter0.97191092
96MP0002572_abnormal_emotion/affect_behav0.96938318
97MP0002638_abnormal_pupillary_reflex0.96683583
98MP0004134_abnormal_chest_morphology0.96653621
99MP0003123_paternal_imprinting0.96599473
100MP0005508_abnormal_skeleton_morphology0.94744807
101* MP0002111_abnormal_tail_morphology0.93667897
102MP0002736_abnormal_nociception_after0.93570847
103MP0008057_abnormal_DNA_replication0.92814380
104MP0002109_abnormal_limb_morphology0.92039420
105MP0004858_abnormal_nervous_system0.91797337
106MP0001849_ear_inflammation0.91633586
107* MP0002752_abnormal_somatic_nervous0.90921499
108MP0009703_decreased_birth_body0.89797217
109MP0002089_abnormal_postnatal_growth/wei0.89551855
110MP0000462_abnormal_digestive_system0.89538091
111MP0006072_abnormal_retinal_apoptosis0.89425375
112MP0005623_abnormal_meninges_morphology0.89042906
113MP0001529_abnormal_vocalization0.87950293
114MP0008932_abnormal_embryonic_tissue0.87355638
115MP0004742_abnormal_vestibular_system0.87133796
116MP0005171_absent_coat_pigmentation0.87126765
117MP0000516_abnormal_urinary_system0.86520650
118MP0005367_renal/urinary_system_phenotyp0.86520650
119MP0005391_vision/eye_phenotype0.85725948
120MP0004197_abnormal_fetal_growth/weight/0.84904751
121* MP0002882_abnormal_neuron_morphology0.84267006
122MP0002277_abnormal_respiratory_mucosa0.84156582
123MP0002557_abnormal_social/conspecific_i0.83665530
124MP0009379_abnormal_foot_pigmentation0.80298574

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.65342052
2Short 4th metacarpal (HP:0010044)3.65342052
3Cortical dysplasia (HP:0002539)3.00648004
4Septo-optic dysplasia (HP:0100842)2.96329413
5Abnormal number of incisors (HP:0011064)2.95377483
6Abnormality of the 4th metacarpal (HP:0010012)2.75099546
7Anophthalmia (HP:0000528)2.71954021
8Split foot (HP:0001839)2.66892055
9Midline defect of the nose (HP:0004122)2.63230004
10Coronal craniosynostosis (HP:0004440)2.59914623
11Abnormality of the parietal bone (HP:0002696)2.57879479
12Turricephaly (HP:0000262)2.53984519
13Vitreoretinal degeneration (HP:0000655)2.52989095
14Cutaneous finger syndactyly (HP:0010554)2.51240987
15Abnormality of the labia minora (HP:0012880)2.50927966
16Esophageal atresia (HP:0002032)2.47073623
17Bilateral microphthalmos (HP:0007633)2.42324302
18Renal duplication (HP:0000075)2.37272486
19Morphological abnormality of the middle ear (HP:0008609)2.36305170
20Maternal diabetes (HP:0009800)2.35974141
21Aplasia cutis congenita (HP:0001057)2.30193395
22Broad thumb (HP:0011304)2.30182369
23Absent septum pellucidum (HP:0001331)2.27965342
24Megalencephaly (HP:0001355)2.27742140
25Neonatal short-limb short stature (HP:0008921)2.25389044
26Rib fusion (HP:0000902)2.25228456
27Parakeratosis (HP:0001036)2.25017470
28Alacrima (HP:0000522)2.24951066
29Cutaneous syndactyly (HP:0012725)2.24219159
30Bronchomalacia (HP:0002780)2.23778105
31High anterior hairline (HP:0009890)2.18932086
32Abnormality of the septum pellucidum (HP:0007375)2.17363373
33Down-sloping shoulders (HP:0200021)2.17143053
34Supernumerary ribs (HP:0005815)2.15228543
35Abnormality of the lacrimal duct (HP:0011481)2.12729904
36Trigonocephaly (HP:0000243)2.12559233
37Concave nail (HP:0001598)2.11407079
38Abnormality of the nasolacrimal system (HP:0000614)2.10552230
39Supernumerary bones of the axial skeleton (HP:0009144)2.09711071
40Abnormality of the incisor (HP:0000676)2.08391293
41Choanal stenosis (HP:0000452)2.06658410
42Preaxial foot polydactyly (HP:0001841)2.05144453
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02706368
44Natal tooth (HP:0000695)2.01063256
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00533114
46Gastrointestinal atresia (HP:0002589)2.00479995
47Broad long bones (HP:0005622)1.99239517
48Anteriorly placed anus (HP:0001545)1.97402525
49Aplasia/Hypoplasia of the sternum (HP:0006714)1.96887668
50Bifid tongue (HP:0010297)1.96402796
51Broad finger (HP:0001500)1.95999037
52Broad phalanges of the hand (HP:0009768)1.95361230
53Intestinal atresia (HP:0011100)1.95122180
54Renal hypoplasia (HP:0000089)1.94774034
55Shawl scrotum (HP:0000049)1.93868526
56Aqueductal stenosis (HP:0002410)1.93671380
57Decreased lacrimation (HP:0000633)1.93669085
58Optic nerve hypoplasia (HP:0000609)1.93516247
59Omphalocele (HP:0001539)1.92588717
60Abnormality of the middle phalanges of the toes (HP:0010183)1.92564488
61Synostosis involving the elbow (HP:0003938)1.91302833
62Humeroradial synostosis (HP:0003041)1.91302833
63Oligodactyly (hands) (HP:0001180)1.90055350
64Broad metatarsal (HP:0001783)1.88236810
65Hypoplastic labia majora (HP:0000059)1.88003771
66Oligodactyly (HP:0012165)1.87958166
67Facial hemangioma (HP:0000329)1.87741251
68Nasolacrimal duct obstruction (HP:0000579)1.87572805
69Abnormality of the diencephalon (HP:0010662)1.87068157
70Broad toe (HP:0001837)1.87034233
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.85082795
72Medulloblastoma (HP:0002885)1.84538080
73Abnormality of the ischium (HP:0003174)1.84370110
74Hepatoblastoma (HP:0002884)1.84323416
75Abnormality of the antihelix (HP:0009738)1.84303278
76Partial duplication of the phalanx of hand (HP:0009999)1.83548508
77Abnormality of the aortic arch (HP:0012303)1.83295205
78Abnormality of the phalanges of the 5th finger (HP:0004213)1.82813321
79Broad phalanx (HP:0006009)1.82438099
80Partial agenesis of the corpus callosum (HP:0001338)1.82297124
81Drooling (HP:0002307)1.82251364
82Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.81358855
83Partial duplication of thumb phalanx (HP:0009944)1.80642408
84Fibular aplasia (HP:0002990)1.80244318
85Myokymia (HP:0002411)1.80187361
86Overriding aorta (HP:0002623)1.80142627
87Cupped ear (HP:0000378)1.79772725
88Increased nuchal translucency (HP:0010880)1.77995790
89Abnormal lung lobation (HP:0002101)1.76140889
90Colon cancer (HP:0003003)1.75636565
91Growth hormone deficiency (HP:0000824)1.75433647
92Atresia of the external auditory canal (HP:0000413)1.74824123
93Mixed hearing impairment (HP:0000410)1.74480887
94Narrow nasal bridge (HP:0000446)1.74313602
95Tracheomalacia (HP:0002779)1.73882475
96Vertebral arch anomaly (HP:0008438)1.73257742
97Renal dysplasia (HP:0000110)1.71589205
98Wide anterior fontanel (HP:0000260)1.70578627
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70410234
100Ectopic anus (HP:0004397)1.70193580
101Abnormality of the labia majora (HP:0012881)1.69984756
102Chin dimple (HP:0010751)1.69748630
103Arnold-Chiari malformation (HP:0002308)1.69414196
104Abnormality of the pubic bones (HP:0003172)1.68968194
105Absent eyebrow (HP:0002223)1.68624476
106Patellar dislocation (HP:0002999)1.68413628
107Aplasia involving bones of the extremities (HP:0009825)1.67872538
108Aplasia involving bones of the upper limbs (HP:0009823)1.67872538
109Aplasia of the phalanges of the hand (HP:0009802)1.67872538
110Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67654956
111Vesicoureteral reflux (HP:0000076)1.67556887
112Labial hypoplasia (HP:0000066)1.67334436
113Hypoplastic female external genitalia (HP:0012815)1.66555973
114Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.65697229
115Abnormality of the phalanges of the hallux (HP:0010057)1.65171253
116Duplication of thumb phalanx (HP:0009942)1.64734641
117Large earlobe (HP:0009748)1.64592161
118Abnormality of the intervertebral disk (HP:0005108)1.64067443
119Hemivertebrae (HP:0002937)1.63472641
120Abdominal situs inversus (HP:0003363)1.62833214
121Abnormality of abdominal situs (HP:0011620)1.62833214
122Short middle phalanx of the 5th finger (HP:0004220)1.62758380
123Abnormality of the nasal septum (HP:0000419)1.62381827
124Aplasia/Hypoplasia of the breasts (HP:0010311)1.62272633
125Abnormality of the lower motor neuron (HP:0002366)1.61356368
126Sleep apnea (HP:0010535)1.61078386
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.60717718
128Focal motor seizures (HP:0011153)1.60704092
129Aplasia/Hypoplasia of the patella (HP:0006498)1.60700725
130Breast aplasia (HP:0100783)1.59454121
131Thin ribs (HP:0000883)1.59226295
132Absent forearm bone (HP:0003953)1.59133210
133Aplasia involving forearm bones (HP:0009822)1.59133210
134Hypoplastic pelvis (HP:0008839)1.58846833
135Broad hallux (HP:0010055)1.58653655
136Excessive salivation (HP:0003781)1.58462958
137Patellar aplasia (HP:0006443)1.58399642
138Absent radius (HP:0003974)1.58337676
139Skull defect (HP:0001362)1.58336170
140Morphological abnormality of the inner ear (HP:0011390)1.58186167
141Shallow orbits (HP:0000586)1.57813281
142Micropenis (HP:0000054)1.56169571
143Preaxial hand polydactyly (HP:0001177)1.56026620
144Limb dystonia (HP:0002451)1.52161058
145Vertebral clefting (HP:0008428)1.51985550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.19612140
2MARK13.62969858
3MKNK12.95405047
4MKNK22.63191210
5DYRK22.48273629
6CASK2.23173243
7CDK122.13619586
8BCR2.11160014
9ERBB32.07614422
10NTRK12.05405205
11SRPK12.01654138
12NTRK22.01306992
13TNIK1.90682840
14FGFR21.87890732
15MAPK131.87832934
16ICK1.71538400
17DYRK31.68770134
18BMPR1B1.67125262
19UHMK11.65058498
20INSRR1.60405876
21KSR11.54251353
22SIK31.53809003
23BRD41.51718918
24CDC71.49403869
25TAF11.48445283
26SIK21.47995147
27ERBB21.29120620
28YES11.26189384
29WEE11.23625442
30CSNK1A1L1.18764898
31DDR21.18752739
32VRK21.16970116
33TYRO31.16249701
34CSNK1G31.12425298
35CDK71.12241470
36CDK31.11133914
37CAMK1D1.08886280
38CDK81.08703351
39LATS21.08302535
40PNCK1.08144333
41LIMK11.07290257
42CHEK21.02966019
43CSNK1G11.02133679
44NEK20.96958165
45MAP2K70.96696022
46PDGFRA0.93287972
47PRKCG0.91377730
48LATS10.89051697
49DYRK1B0.87215500
50DYRK1A0.86462254
51FGFR10.86115968
52PLK30.84334300
53PKN10.83005527
54STK38L0.82680902
55CSNK1G20.82371350
56MAP3K90.82068702
57EPHA30.79786934
58PAK60.78057516
59SGK4940.78009124
60SGK2230.78009124
61ATR0.76235265
62MINK10.75701493
63PLK40.74531283
64VRK10.73420456
65FGR0.72960753
66TGFBR10.72715634
67NME10.71635084
68CHEK10.71110015
69MAP3K100.69791441
70PASK0.67706711
71TTK0.66743346
72CLK10.65173198
73CDK10.64714328
74PRPF4B0.64282717
75CDK50.64052929
76TRIM280.64052580
77MARK20.63997689
78MAP3K40.63639725
79ADRBK20.63299462
80ROCK20.63209927
81MAPK150.63140531
82STK30.63087533
83CAMK1G0.62111655
84EPHA40.61268447
85STK240.61148552
86TSSK60.60762154
87ATM0.60732379
88SIK10.60047118
89CDK180.59882610
90PLK20.59178417
91EEF2K0.58327967
92SGK20.58205899
93CDK140.58107430
94HIPK20.57964826
95STK390.57152532
96CDK11A0.56466627
97PRKD30.56188353
98CSNK1E0.56112075
99CDK150.56077442
100NTRK30.55623829
101CDK20.54808572
102ADRBK10.52639337
103MAPK90.52599715
104EIF2AK20.51447963
105GSK3B0.49141605
106CDC42BPA0.49111483
107WNK10.49056406
108BUB10.48972988
109NEK60.48358039
110RPS6KA40.47759046
111* CSNK1D0.46794826
112PAK30.46710905
113CDK190.46520117
114AURKA0.45861394
115WNK30.45347941
116AKT20.44707246
117TLK10.43857782
118GSK3A0.43832515
119PRKDC0.42706613
120CAMK40.42106690
121MAP2K40.41522310
122MTOR0.41036794
123PLK10.41027843
124PAK40.40764258
125STK110.40730187
126ALK0.40606972
127PHKG20.40396562
128PRKCZ0.35675383
129PRKCE0.34503613
130MAPK100.34341904

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.87894069
2Hedgehog signaling pathway_Homo sapiens_hsa043403.18717823
3Axon guidance_Homo sapiens_hsa043602.80365960
4Spliceosome_Homo sapiens_hsa030402.45915474
5Hippo signaling pathway_Homo sapiens_hsa043902.45639128
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.13674898
7Notch signaling pathway_Homo sapiens_hsa043302.10756133
8* Wnt signaling pathway_Homo sapiens_hsa043102.10690037
9mRNA surveillance pathway_Homo sapiens_hsa030151.84223715
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77934030
11Ribosome_Homo sapiens_hsa030101.66367471
12Melanogenesis_Homo sapiens_hsa049161.60246449
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55378243
14MicroRNAs in cancer_Homo sapiens_hsa052061.55236757
15Adherens junction_Homo sapiens_hsa045201.48727766
16TGF-beta signaling pathway_Homo sapiens_hsa043501.44875559
17Cell cycle_Homo sapiens_hsa041101.40697760
18Nicotine addiction_Homo sapiens_hsa050331.40280539
19Colorectal cancer_Homo sapiens_hsa052101.39584470
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36803501
21Basal transcription factors_Homo sapiens_hsa030221.36491090
22Mismatch repair_Homo sapiens_hsa034301.35077102
23RNA transport_Homo sapiens_hsa030131.21042483
24Tight junction_Homo sapiens_hsa045301.19176854
25Steroid biosynthesis_Homo sapiens_hsa001001.18492374
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17840221
27Fanconi anemia pathway_Homo sapiens_hsa034601.17164453
28Endometrial cancer_Homo sapiens_hsa052131.16290477
29Cardiac muscle contraction_Homo sapiens_hsa042601.14794787
30Pathways in cancer_Homo sapiens_hsa052001.14390844
31ErbB signaling pathway_Homo sapiens_hsa040121.12833827
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09251161
33Homologous recombination_Homo sapiens_hsa034401.07748067
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06813316
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06549960
36DNA replication_Homo sapiens_hsa030301.04334398
37Melanoma_Homo sapiens_hsa052181.02850313
38Prostate cancer_Homo sapiens_hsa052151.02744351
39Amphetamine addiction_Homo sapiens_hsa050311.01775254
40Protein digestion and absorption_Homo sapiens_hsa049740.98460209
41Serotonergic synapse_Homo sapiens_hsa047260.98178697
42Protein export_Homo sapiens_hsa030600.97761762
43RNA degradation_Homo sapiens_hsa030180.96984661
44Renal cell carcinoma_Homo sapiens_hsa052110.96066713
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95969062
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95203730
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94254863
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93808176
49RNA polymerase_Homo sapiens_hsa030200.91950113
50Glutamatergic synapse_Homo sapiens_hsa047240.91452985
51Gap junction_Homo sapiens_hsa045400.91407168
52Nucleotide excision repair_Homo sapiens_hsa034200.90396556
53Base excision repair_Homo sapiens_hsa034100.88584609
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87379677
55Proteoglycans in cancer_Homo sapiens_hsa052050.86928251
56Ether lipid metabolism_Homo sapiens_hsa005650.86395952
57HTLV-I infection_Homo sapiens_hsa051660.86202862
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84047760
59Long-term depression_Homo sapiens_hsa047300.83157012
60Alcoholism_Homo sapiens_hsa050340.81131787
61Ras signaling pathway_Homo sapiens_hsa040140.81128421
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81037811
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80643852
64Cocaine addiction_Homo sapiens_hsa050300.76930699
65Rap1 signaling pathway_Homo sapiens_hsa040150.76433093
66Taste transduction_Homo sapiens_hsa047420.76424800
67Dorso-ventral axis formation_Homo sapiens_hsa043200.76061120
68Dilated cardiomyopathy_Homo sapiens_hsa054140.74243848
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73783369
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72419735
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71971157
72Oocyte meiosis_Homo sapiens_hsa041140.71760303
73Lysine degradation_Homo sapiens_hsa003100.70700979
74Glioma_Homo sapiens_hsa052140.68638723
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68112379
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67280147
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66128313
78Non-homologous end-joining_Homo sapiens_hsa034500.66117601
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65798527
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.65592937
81Huntingtons disease_Homo sapiens_hsa050160.64752950
82MAPK signaling pathway_Homo sapiens_hsa040100.64479371
83Phototransduction_Homo sapiens_hsa047440.64254453
84Chronic myeloid leukemia_Homo sapiens_hsa052200.63709724
85Viral myocarditis_Homo sapiens_hsa054160.63329378
86GABAergic synapse_Homo sapiens_hsa047270.62037136
87p53 signaling pathway_Homo sapiens_hsa041150.60742844
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60378131
89Dopaminergic synapse_Homo sapiens_hsa047280.60347962
90ECM-receptor interaction_Homo sapiens_hsa045120.59847362
91Insulin secretion_Homo sapiens_hsa049110.59370762
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59286728
93Choline metabolism in cancer_Homo sapiens_hsa052310.59020752
94Long-term potentiation_Homo sapiens_hsa047200.57701379
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56560324
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56238804
97Bladder cancer_Homo sapiens_hsa052190.54837284
98Circadian entrainment_Homo sapiens_hsa047130.53817462
99Morphine addiction_Homo sapiens_hsa050320.52774702
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51563646
101Focal adhesion_Homo sapiens_hsa045100.51210223
102Sphingolipid metabolism_Homo sapiens_hsa006000.51120978
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49479847
104Estrogen signaling pathway_Homo sapiens_hsa049150.48792993
105Parkinsons disease_Homo sapiens_hsa050120.48219755
106Small cell lung cancer_Homo sapiens_hsa052220.47570103
107Thyroid hormone synthesis_Homo sapiens_hsa049180.47209183
108Cholinergic synapse_Homo sapiens_hsa047250.47182814
109Non-small cell lung cancer_Homo sapiens_hsa052230.47180576
110Oxytocin signaling pathway_Homo sapiens_hsa049210.44585939
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.43650158
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43202722
113Renin secretion_Homo sapiens_hsa049240.41478218
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40352119
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.40314619
116GnRH signaling pathway_Homo sapiens_hsa049120.40027037
117Olfactory transduction_Homo sapiens_hsa047400.39778636
118Thyroid cancer_Homo sapiens_hsa052160.39508075
119Pancreatic cancer_Homo sapiens_hsa052120.38469604
120cAMP signaling pathway_Homo sapiens_hsa040240.38449515
121Gastric acid secretion_Homo sapiens_hsa049710.36594813
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36288295
123AMPK signaling pathway_Homo sapiens_hsa041520.35625351

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