VAPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.02592296
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41127026
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37831271
4plasma membrane repair (GO:0001778)3.36511730
5regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35746996
6sodium ion export (GO:0071436)3.30117458
7activation of protein kinase A activity (GO:0034199)3.29024260
8locomotory exploration behavior (GO:0035641)3.20316714
9layer formation in cerebral cortex (GO:0021819)3.11347430
10desmosome organization (GO:0002934)3.08601562
11proline transport (GO:0015824)3.06939532
12protein localization to endosome (GO:0036010)3.05541727
13cell-substrate adherens junction assembly (GO:0007045)3.03412850
14focal adhesion assembly (GO:0048041)3.03412850
15cell communication by electrical coupling (GO:0010644)3.01706827
16adherens junction assembly (GO:0034333)3.00014211
17protein localization to microtubule (GO:0035372)2.99971034
18negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99596827
19cytoskeletal anchoring at plasma membrane (GO:0007016)2.99466068
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90926942
21paraxial mesoderm development (GO:0048339)2.87323139
22cerebellar granule cell differentiation (GO:0021707)2.87208902
23cellular potassium ion homeostasis (GO:0030007)2.87181415
24embryonic retina morphogenesis in camera-type eye (GO:0060059)2.86522842
25glutamate secretion (GO:0014047)2.84453780
26cerebellar Purkinje cell layer development (GO:0021680)2.81896252
27lysine catabolic process (GO:0006554)2.81272273
28lysine metabolic process (GO:0006553)2.81272273
29negative regulation of potassium ion transmembrane transport (GO:1901380)2.80822314
30alanine transport (GO:0032328)2.79910537
31macroautophagy (GO:0016236)2.78045140
32negative regulation of dendrite morphogenesis (GO:0050774)2.75689893
33potassium ion import (GO:0010107)2.74799912
34regulation of NFAT protein import into nucleus (GO:0051532)2.72799162
35response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.71169658
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.69436035
37negative regulation of cell size (GO:0045792)2.67809468
38regulation of synaptic vesicle exocytosis (GO:2000300)2.66150846
39protein retention in ER lumen (GO:0006621)2.65066842
40alpha-linolenic acid metabolic process (GO:0036109)2.64162346
41neurotransmitter secretion (GO:0007269)2.64154855
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.62666181
43synaptic vesicle exocytosis (GO:0016079)2.62371567
44cell communication involved in cardiac conduction (GO:0086065)2.61850672
45apical protein localization (GO:0045176)2.61458891
46synaptic vesicle docking involved in exocytosis (GO:0016081)2.60575807
47positive regulation of synapse maturation (GO:0090129)2.58080498
48dicarboxylic acid biosynthetic process (GO:0043650)2.57557182
49carnitine shuttle (GO:0006853)2.54525661
50regulation of ARF protein signal transduction (GO:0032012)2.52928185
51response to parathyroid hormone (GO:0071107)2.52649920
52regulation of cholesterol homeostasis (GO:2000188)2.51684314
53regulation of fatty acid beta-oxidation (GO:0031998)2.51047174
54gamma-aminobutyric acid transport (GO:0015812)2.49504193
55fatty acid transmembrane transport (GO:1902001)2.48934256
56glycine transport (GO:0015816)2.48762338
57cell-substrate junction assembly (GO:0007044)2.45617885
58neuromuscular process controlling balance (GO:0050885)2.43734491
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43598562
60L-phenylalanine metabolic process (GO:0006558)2.43598562
61sarcoplasmic reticulum calcium ion transport (GO:0070296)2.43229697
62neuromuscular process controlling posture (GO:0050884)2.42754932
63aspartate family amino acid catabolic process (GO:0009068)2.42348491
64positive regulation of fatty acid beta-oxidation (GO:0032000)2.42164613
65regulation of synapse structural plasticity (GO:0051823)2.40978566
66glutamate metabolic process (GO:0006536)2.39347554
672-oxoglutarate metabolic process (GO:0006103)2.39136865
68regulation of clathrin-mediated endocytosis (GO:2000369)2.37998421
69L-phenylalanine catabolic process (GO:0006559)2.33593795
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.33593795
71regulation of synaptic vesicle transport (GO:1902803)2.32670846
72asymmetric protein localization (GO:0008105)2.32280170
73cellular modified amino acid catabolic process (GO:0042219)2.31345992
74vocalization behavior (GO:0071625)2.31294259
75regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30731290
76membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.29932975
77positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.29217387
784-hydroxyproline metabolic process (GO:0019471)2.29142099
79regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.28997959
80regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.28388787
81cellular sodium ion homeostasis (GO:0006883)2.26076813
82Golgi transport vesicle coating (GO:0048200)2.24842058
83COPI coating of Golgi vesicle (GO:0048205)2.24842058
84dendrite morphogenesis (GO:0048813)2.24351240
85mating behavior (GO:0007617)2.24027394
86notochord development (GO:0030903)2.23950847
87stress fiber assembly (GO:0043149)2.22868057
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.22321157
89peripheral nervous system axon ensheathment (GO:0032292)2.22099983
90myelination in peripheral nervous system (GO:0022011)2.22099983
91dicarboxylic acid catabolic process (GO:0043649)2.22007036
92vesicle transport along microtubule (GO:0047496)2.21621059
93epithelial cell-cell adhesion (GO:0090136)2.21133209
94potassium ion homeostasis (GO:0055075)2.21037177
95sulfur amino acid catabolic process (GO:0000098)2.20614152
96neuronal action potential propagation (GO:0019227)2.19426083
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.18456309
98vesicle coating (GO:0006901)2.18124155
99suckling behavior (GO:0001967)2.16335589
100regulation of RNA export from nucleus (GO:0046831)2.15851453
101regulation of long-term neuronal synaptic plasticity (GO:0048169)2.15688197
102amino acid import (GO:0043090)2.15074283
103mitotic chromosome condensation (GO:0007076)2.14908427
104tricarboxylic acid metabolic process (GO:0072350)2.14613719
105regulation of fatty acid oxidation (GO:0046320)2.14007726
106body morphogenesis (GO:0010171)2.13543125
107hippo signaling (GO:0035329)2.13024773
108* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.12771311
109regulation of early endosome to late endosome transport (GO:2000641)2.12747181
110regulation of nucleobase-containing compound transport (GO:0032239)2.12578713
111exploration behavior (GO:0035640)2.12017395
112positive regulation of glycogen biosynthetic process (GO:0045725)2.11962568
113regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.11881359
114membrane repolarization (GO:0086009)2.11710750
115glucocorticoid receptor signaling pathway (GO:0042921)2.10955973
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.10926348
117organelle transport along microtubule (GO:0072384)2.10511693
118insulin-like growth factor receptor signaling pathway (GO:0048009)2.09487528
119positive regulation of glucose import (GO:0046326)2.09091986
120myotube differentiation (GO:0014902)2.08969844
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.08620785
122axon cargo transport (GO:0008088)2.08589453
123positive regulation of fatty acid oxidation (GO:0046321)2.07894834
124apoptotic cell clearance (GO:0043277)2.07430535
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.06721017
126NADH metabolic process (GO:0006734)2.06534225
127cellular ketone body metabolic process (GO:0046950)2.06413823
128bundle of His cell to Purkinje myocyte communication (GO:0086069)2.06099865
129regulation of glutamate receptor signaling pathway (GO:1900449)2.05506970
130positive regulation of glucose transport (GO:0010828)2.05396920
131sarcomere organization (GO:0045214)2.05261993
132regulation of neuronal synaptic plasticity (GO:0048168)2.05066166
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.05061143
134myelin maintenance (GO:0043217)2.04993304
135neutral lipid catabolic process (GO:0046461)2.04377834
136acylglycerol catabolic process (GO:0046464)2.04377834
137muscle filament sliding (GO:0030049)2.03833022
138actin-myosin filament sliding (GO:0033275)2.03833022
139cell migration in hindbrain (GO:0021535)2.03362070
140regulation of calcium ion transmembrane transporter activity (GO:1901019)2.03354638
141regulation of calcium ion transmembrane transport (GO:1903169)2.03354638
142skeletal muscle contraction (GO:0003009)2.03273985
143embryonic camera-type eye morphogenesis (GO:0048596)2.03029149
144NLS-bearing protein import into nucleus (GO:0006607)2.02798318
145positive regulation of nitric-oxide synthase activity (GO:0051000)2.02455226
146regulation of ARF GTPase activity (GO:0032312)2.02441833
147cellular response to prostaglandin stimulus (GO:0071379)2.02369805
148triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.02366071
149regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.02357993
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.02054096
151positive regulation of dendritic spine morphogenesis (GO:0061003)2.01834583
152myoblast fusion (GO:0007520)1.99839327
153cardiac muscle contraction (GO:0060048)1.99205465
154ectodermal placode formation (GO:0060788)1.99039195
155establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.97950317
156activation of Rac GTPase activity (GO:0032863)1.97669308
157branching involved in salivary gland morphogenesis (GO:0060445)1.97576097
158striated muscle contraction (GO:0006941)1.96901713
159cellular response to catecholamine stimulus (GO:0071870)1.96453141
160cellular response to monoamine stimulus (GO:0071868)1.96453141
161camera-type eye morphogenesis (GO:0048593)1.96419547
162biotin metabolic process (GO:0006768)1.96398018
163adherens junction organization (GO:0034332)1.95737787
164actomyosin structure organization (GO:0031032)1.94318923
165negative regulation of vascular permeability (GO:0043116)1.93666938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95156418
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.86435324
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.72121034
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42927450
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.32708588
6AR_21909140_ChIP-Seq_LNCAP_Human2.23765732
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15876946
8EZH2_22144423_ChIP-Seq_EOC_Human2.14735783
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.09726862
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.04291089
11PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97957960
12RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95148684
13ERG_21242973_ChIP-ChIP_JURKAT_Human1.91842385
14DROSHA_22980978_ChIP-Seq_HELA_Human1.90045467
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.88471406
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87512167
17KDM2B_26808549_Chip-Seq_K562_Human1.84450494
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83243929
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.82100335
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78941096
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76971432
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74609678
23ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74497204
24ZNF263_19887448_ChIP-Seq_K562_Human1.73000663
25LXR_22292898_ChIP-Seq_THP-1_Human1.72406775
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71944609
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71944609
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71498751
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.69617316
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.69532584
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66417397
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65209117
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61319037
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60921922
35CLOCK_20551151_ChIP-Seq_293T_Human1.57969275
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56837865
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55974787
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53367122
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51447702
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50754850
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49361038
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46774783
43CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44427129
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44137455
45KDM2B_26808549_Chip-Seq_DND41_Human1.41164161
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40728456
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40697261
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38843436
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.38175052
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37194487
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37098611
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36751547
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36448134
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35912488
55REST_21632747_ChIP-Seq_MESCs_Mouse1.35848421
56* REST_18959480_ChIP-ChIP_MESCs_Mouse1.35176236
57E2F7_22180533_ChIP-Seq_HELA_Human1.33291139
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.33043645
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31945497
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31644530
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31088173
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30441214
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28653944
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27464001
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26745685
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25443357
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25139126
68* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24323178
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24161164
70RACK7_27058665_Chip-Seq_MCF-7_Human1.23748032
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.23729874
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23633757
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.23039009
74CREB1_26743006_Chip-Seq_LNCaP_Human1.22638432
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22548606
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21842815
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.21728194
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.20825585
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20613313
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18445491
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18342206
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17751255
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17089794
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15659095
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.15243284
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14652489
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.14395191
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14101464
89ZNF274_21170338_ChIP-Seq_K562_Hela1.11309035
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.10435640
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.09130974
92CTCF_27219007_Chip-Seq_Bcells_Human1.08371638
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.08076063
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.08076063
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07149174
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06683234
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06588132
98* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05808802
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.05638599
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.05320152
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04844753
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03567884
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02064662
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.01108441
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01086567
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00955093
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00718112
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99776382
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99355245
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99351492
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99114390
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98514613
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.98278690
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.97896638
115EED_16625203_ChIP-ChIP_MESCs_Mouse0.97706830
116ATF3_27146783_Chip-Seq_COLON_Human0.97111265
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.96145044
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95602759
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95602690
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.95566439
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95173263
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.94531317
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94404741
124* SMC4_20622854_ChIP-Seq_HELA_Human0.93900222
125CHD1_26751641_Chip-Seq_LNCaP_Human0.93052378
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92922263
127AR_19668381_ChIP-Seq_PC3_Human0.92454250
128GATA1_19941826_ChIP-Seq_K562_Human0.92286849
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92189975
130* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92140279
131KLF4_19829295_ChIP-Seq_ESCs_Human0.91423816
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91384760
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91376823
134AHR_22903824_ChIP-Seq_MCF-7_Human0.90478587
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.89433695
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.88245731
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.88243626
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88090688
139* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87507271
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85992333
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.85166409
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84847679
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84701861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.58619756
2MP0002139_abnormal_hepatobiliary_system2.69584699
3MP0002909_abnormal_adrenal_gland2.63083933
4MP0003705_abnormal_hypodermis_morpholog2.57620857
5MP0002837_dystrophic_cardiac_calcinosis2.50567880
6MP0005409_darkened_coat_color2.48364624
7MP0003123_paternal_imprinting2.46447505
8MP0003283_abnormal_digestive_organ2.46259895
9MP0009780_abnormal_chondrocyte_physiolo2.41959564
10MP0004270_analgesia2.37969027
11MP0000751_myopathy2.34969505
12MP0004130_abnormal_muscle_cell2.30090036
13MP0004858_abnormal_nervous_system2.21336147
14MP0005360_urolithiasis2.20709434
15MP0000579_abnormal_nail_morphology2.06726179
16MP0003329_amyloid_beta_deposits2.02957113
17MP0003635_abnormal_synaptic_transmissio2.01000838
18MP0008961_abnormal_basal_metabolism1.98955209
19MP0000013_abnormal_adipose_tissue1.92818007
20MP0005085_abnormal_gallbladder_physiolo1.91563743
21MP0005365_abnormal_bile_salt1.88700625
22MP0005083_abnormal_biliary_tract1.82934866
23MP0000747_muscle_weakness1.76643702
24MP0004145_abnormal_muscle_electrophysio1.75471964
25MP0010234_abnormal_vibrissa_follicle1.63894730
26MP0003122_maternal_imprinting1.61931376
27MP0005423_abnormal_somatic_nervous1.61338209
28MP0004043_abnormal_pH_regulation1.60835761
29MP0003252_abnormal_bile_duct1.60562139
30MP0005076_abnormal_cell_differentiation1.60123871
31MP0003566_abnormal_cell_adhesion1.55724673
32MP0004185_abnormal_adipocyte_glucose1.54747146
33MP0004264_abnormal_extraembryonic_tissu1.50608643
34MP0003941_abnormal_skin_development1.49248923
35MP0010329_abnormal_lipoprotein_level1.46955896
36MP0002064_seizures1.44273238
37MP0002063_abnormal_learning/memory/cond1.43918783
38MP0009672_abnormal_birth_weight1.43206256
39MP0004036_abnormal_muscle_relaxation1.41878119
40MP0003879_abnormal_hair_cell1.41412912
41MP0000566_synostosis1.41408198
42MP0002269_muscular_atrophy1.40703040
43MP0001346_abnormal_lacrimal_gland1.39442005
44MP0005623_abnormal_meninges_morphology1.37798620
45MP0004087_abnormal_muscle_fiber1.36119032
46MP0003300_gastrointestinal_ulcer1.35442851
47MP0003195_calcinosis1.35144362
48MP0000604_amyloidosis1.34222083
49MP0004084_abnormal_cardiac_muscle1.31581697
50MP0005666_abnormal_adipose_tissue1.31381368
51MP0004233_abnormal_muscle_weight1.31348459
52MP0009046_muscle_twitch1.30251872
53MP0002733_abnormal_thermal_nociception1.28254830
54MP0000749_muscle_degeneration1.27772043
55MP0002877_abnormal_melanocyte_morpholog1.27390424
56MP0009840_abnormal_foam_cell1.27351611
57MP0002734_abnormal_mechanical_nocicepti1.25922191
58MP0008875_abnormal_xenobiotic_pharmacok1.25842351
59MP0000003_abnormal_adipose_tissue1.25528783
60MP0003172_abnormal_lysosome_physiology1.24856276
61MP0005257_abnormal_intraocular_pressure1.24677561
62MP0000733_abnormal_muscle_development1.23848335
63MP0002822_catalepsy1.23758477
64MP0005375_adipose_tissue_phenotype1.23652333
65MP0003942_abnormal_urinary_system1.23007393
66MP0009745_abnormal_behavioral_response1.22580903
67MP0001849_ear_inflammation1.20989425
68MP0010352_gastrointestinal_tract_polyps1.20749464
69MP0005167_abnormal_blood-brain_barrier1.20484775
70MP0005451_abnormal_body_composition1.19619981
71MP0003880_abnormal_central_pattern1.19432192
72MP0002118_abnormal_lipid_homeostasis1.19397536
73MP0003045_fibrosis1.19369792
74MP0002078_abnormal_glucose_homeostasis1.17985918
75MP0003690_abnormal_glial_cell1.17798303
76MP0003633_abnormal_nervous_system1.17168374
77MP0002796_impaired_skin_barrier1.16552227
78MP0005332_abnormal_amino_acid1.15805174
79MP0005058_abnormal_lysosome_morphology1.15456355
80MP0000462_abnormal_digestive_system1.15076225
81MP0000537_abnormal_urethra_morphology1.14542983
82MP0002249_abnormal_larynx_morphology1.13005276
83MP0000534_abnormal_ureter_morphology1.11662195
84MP0010630_abnormal_cardiac_muscle1.10686853
85MP0002108_abnormal_muscle_morphology1.08958530
86MP0002089_abnormal_postnatal_growth/wei1.08705858
87MP0004811_abnormal_neuron_physiology1.07556868
88MP0005535_abnormal_body_temperature1.07326692
89MP0005330_cardiomyopathy1.07254944
90MP0000759_abnormal_skeletal_muscle1.07047544
91MP0002572_abnormal_emotion/affect_behav1.06812656
92MP0006138_congestive_heart_failure1.05878544
93MP0000762_abnormal_tongue_morphology1.04951762
94MP0001968_abnormal_touch/_nociception1.02125993
95MP0000955_abnormal_spinal_cord1.01909570
96MP0001666_abnormal_nutrient_absorption1.01304837
97MP0010678_abnormal_skin_adnexa1.01221015
98MP0008438_abnormal_cutaneous_collagen1.00506392
99MP0005620_abnormal_muscle_contractility0.99250125
100MP0010368_abnormal_lymphatic_system0.99140012
101MP0001970_abnormal_pain_threshold0.98764280
102MP0003075_altered_response_to0.98060972
103MP0010030_abnormal_orbit_morphology0.96479609
104MP0000778_abnormal_nervous_system0.96333369
105MP0002272_abnormal_nervous_system0.96100702
106MP0004885_abnormal_endolymph0.95666136
107MP0004215_abnormal_myocardial_fiber0.95612751
108MP0005369_muscle_phenotype0.95173468
109MP0001440_abnormal_grooming_behavior0.94855940
110MP0002896_abnormal_bone_mineralization0.94728435
111MP0009053_abnormal_anal_canal0.94128139
112MP0008569_lethality_at_weaning0.94052706
113MP0002184_abnormal_innervation0.93645959
114MP0001348_abnormal_lacrimal_gland0.90760888
115MP0001299_abnormal_eye_distance/0.89797433
116MP0004085_abnormal_heartbeat0.89561038
117MP0003646_muscle_fatigue0.88519120
118MP0002971_abnormal_brown_adipose0.87211102
119MP0005501_abnormal_skin_physiology0.87066384
120MP0002697_abnormal_eye_size0.86707098
121MP0003453_abnormal_keratinocyte_physiol0.86586503
122MP0001944_abnormal_pancreas_morphology0.85683651
123MP0003634_abnormal_glial_cell0.85561183
124MP0002106_abnormal_muscle_physiology0.85378770
125MP0003137_abnormal_impulse_conducting0.85072456
126MP0000678_abnormal_parathyroid_gland0.84617998
127MP0001730_embryonic_growth_arrest0.84222457
128MP0003890_abnormal_embryonic-extraembry0.83253019
129MP0003115_abnormal_respiratory_system0.83209784
130MP0002090_abnormal_vision0.82945129
131MP0003191_abnormal_cellular_cholesterol0.82556095
132MP0003868_abnormal_feces_composition0.81470067
133MP0005584_abnormal_enzyme/coenzyme_acti0.81148060
134MP0004272_abnormal_basement_membrane0.80852790
135MP0000750_abnormal_muscle_regeneration0.80457635
136MP0002972_abnormal_cardiac_muscle0.80326047
137MP0002066_abnormal_motor_capabilities/c0.80305924
138MP0008874_decreased_physiological_sensi0.80294118
139MP0003631_nervous_system_phenotype0.79647599
140MP0003303_peritoneal_inflammation0.78482792
141MP0003861_abnormal_nervous_system0.78391560
142MP0000377_abnormal_hair_follicle0.76651454
143MP0005187_abnormal_penis_morphology0.76488509
144MP0002098_abnormal_vibrissa_morphology0.76365714
145MP0001501_abnormal_sleep_pattern0.75824220
146MP0005670_abnormal_white_adipose0.75747673
147MP0003385_abnormal_body_wall0.75680333
148MP0001765_abnormal_ion_homeostasis0.75655007
149MP0002067_abnormal_sensory_capabilities0.75286058
150MP0002152_abnormal_brain_morphology0.72681023
151MP0009703_decreased_birth_body0.72384219
152MP0001879_abnormal_lymphatic_vessel0.71942942
153MP0000383_abnormal_hair_follicle0.71884297
154MP0003984_embryonic_growth_retardation0.71324424
155MP0002081_perinatal_lethality0.70367760
156MP0003935_abnormal_craniofacial_develop0.69340662
157MP0001672_abnormal_embryogenesis/_devel0.69046311

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)2.98634758
2Ketoacidosis (HP:0001993)2.93675193
3Muscle fiber inclusion bodies (HP:0100299)2.90060504
4Visual hallucinations (HP:0002367)2.88259745
5Difficulty running (HP:0009046)2.87291267
6Nemaline bodies (HP:0003798)2.87243078
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.80044473
8Hyporeflexia of lower limbs (HP:0002600)2.76680394
9Myokymia (HP:0002411)2.75000258
10Abnormality of the lower motor neuron (HP:0002366)2.68894534
11Abnormality of the Achilles tendon (HP:0005109)2.65735233
12Myoglobinuria (HP:0002913)2.63193788
13Deep venous thrombosis (HP:0002625)2.60362823
14Supranuclear gaze palsy (HP:0000605)2.59937426
15Achilles tendon contracture (HP:0001771)2.59720408
16Exercise-induced muscle cramps (HP:0003710)2.59003014
17Ketosis (HP:0001946)2.54236289
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.52931028
19Right ventricular cardiomyopathy (HP:0011663)2.49797885
20Asymmetry of the thorax (HP:0001555)2.47762336
21Turricephaly (HP:0000262)2.47055707
22Upper limb amyotrophy (HP:0009129)2.43774577
23Distal upper limb amyotrophy (HP:0007149)2.43774577
24Action tremor (HP:0002345)2.42219683
25Cerebral aneurysm (HP:0004944)2.41009132
26Cerebral inclusion bodies (HP:0100314)2.39936572
27Hyperinsulinemic hypoglycemia (HP:0000825)2.35781887
28Asymmetric septal hypertrophy (HP:0001670)2.35587711
29Xanthomatosis (HP:0000991)2.34013819
30Bundle branch block (HP:0011710)2.32545729
31Obstructive sleep apnea (HP:0002870)2.29768866
32Sudden death (HP:0001699)2.29684071
33Pheochromocytoma (HP:0002666)2.27359237
34Hypercortisolism (HP:0001578)2.27255257
35Gout (HP:0001997)2.24349055
36Hypoglycemic coma (HP:0001325)2.23057934
37Termporal pattern (HP:0011008)2.22221500
38Insidious onset (HP:0003587)2.22221500
39Hand muscle atrophy (HP:0009130)2.21503059
40Increased variability in muscle fiber diameter (HP:0003557)2.20385503
41Lower limb amyotrophy (HP:0007210)2.16169011
42Resting tremor (HP:0002322)2.16160665
43Focal seizures (HP:0007359)2.14484285
44Rapidly progressive (HP:0003678)2.14402785
45Centrally nucleated skeletal muscle fibers (HP:0003687)2.13100268
46Papilledema (HP:0001085)2.13063357
47Myopathic facies (HP:0002058)2.12669837
48Ventricular fibrillation (HP:0001663)2.11062129
49Depression (HP:0000716)2.10450404
50Akinesia (HP:0002304)2.10441688
51Skin nodule (HP:0200036)2.10187786
52Myotonia (HP:0002486)2.09500263
53Neurofibrillary tangles (HP:0002185)2.08784551
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07620468
55Global brain atrophy (HP:0002283)2.06710163
56Distal lower limb amyotrophy (HP:0008944)2.06669124
57Ankle clonus (HP:0011448)2.03487711
58Septate vagina (HP:0001153)2.01494865
59Lymphangioma (HP:0100764)2.00721284
60Macroorchidism (HP:0000053)1.97371214
61Difficulty climbing stairs (HP:0003551)1.97052667
62Increased connective tissue (HP:0009025)1.95977878
63Shallow orbits (HP:0000586)1.95697900
64Abnormal social behavior (HP:0012433)1.95627909
65Impaired social interactions (HP:0000735)1.95627909
66Overriding aorta (HP:0002623)1.94251668
67Distal lower limb muscle weakness (HP:0009053)1.94161719
68Mucopolysacchariduria (HP:0008155)1.93673568
69Urinary glycosaminoglycan excretion (HP:0003541)1.93673568
70Vertebral arch anomaly (HP:0008438)1.92459762
71Heterotopia (HP:0002282)1.92402111
72Abnormality of the left ventricular outflow tract (HP:0011103)1.92335757
73Subaortic stenosis (HP:0001682)1.92335757
74Agitation (HP:0000713)1.92123399
75Insomnia (HP:0100785)1.92096783
76Dysmetric saccades (HP:0000641)1.91911854
77Hamartoma of the eye (HP:0010568)1.90557492
78Hyperparathyroidism (HP:0000843)1.90126674
79Protrusio acetabuli (HP:0003179)1.88880583
80Back pain (HP:0003418)1.84840009
81Foot dorsiflexor weakness (HP:0009027)1.84635679
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84041244
83Type 1 muscle fiber predominance (HP:0003803)1.83769388
84Postural instability (HP:0002172)1.83555280
85Abnormality of skeletal muscle fiber size (HP:0012084)1.83229547
86Muscle stiffness (HP:0003552)1.82775147
87Ankyloglossia (HP:0010296)1.82316081
88Late onset (HP:0003584)1.80810389
89Frequent falls (HP:0002359)1.80317516
90Generalized tonic-clonic seizures (HP:0002069)1.80015398
91Urinary urgency (HP:0000012)1.79542451
92Long toe (HP:0010511)1.78576276
93Dysostosis multiplex (HP:0000943)1.78397837
94Flat acetabular roof (HP:0003180)1.78125834
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.78082313
96Hypoglycemic seizures (HP:0002173)1.77450238
97Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77159102
98Abnormality of polysaccharide metabolism (HP:0011012)1.77159102
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77159102
100Focal motor seizures (HP:0011153)1.77043174
101Calcaneovalgus deformity (HP:0001848)1.76883448
102Status epilepticus (HP:0002133)1.76496094
103Hyperphosphatemia (HP:0002905)1.76269589
104Hemiplegia (HP:0002301)1.76103768
105Increased nuchal translucency (HP:0010880)1.75317541
106Impaired vibration sensation in the lower limbs (HP:0002166)1.75200591
107Renal duplication (HP:0000075)1.73590539
108EMG: myopathic abnormalities (HP:0003458)1.73506359
109Hyperthyroidism (HP:0000836)1.72563466
110Neuroendocrine neoplasm (HP:0100634)1.72481052
111Increased CSF protein (HP:0002922)1.72423439
112Abnormality of the foot musculature (HP:0001436)1.71949094
113Intrahepatic cholestasis (HP:0001406)1.71841855
114Absence seizures (HP:0002121)1.71707482
115Mildly elevated creatine phosphokinase (HP:0008180)1.71459361
116Complement deficiency (HP:0004431)1.70776790
117Muscle hypertrophy of the lower extremities (HP:0008968)1.70725933
118Hyperacusis (HP:0010780)1.70350394
119Neonatal onset (HP:0003623)1.70157336
120Calf muscle hypertrophy (HP:0008981)1.68851713
121Torticollis (HP:0000473)1.67949162
122Atrioventricular block (HP:0001678)1.67421320
123Muscle fiber splitting (HP:0003555)1.66824407
124Spinal rigidity (HP:0003306)1.66575240
125Intention tremor (HP:0002080)1.66432732
126Aneurysm (HP:0002617)1.66383205
127Hyperglycemia (HP:0003074)1.65838956
128Papillary thyroid carcinoma (HP:0002895)1.65808626
129Hammertoe (HP:0001765)1.65596321
130Broad metatarsal (HP:0001783)1.65532225
131Bronchomalacia (HP:0002780)1.63746673
132Microglossia (HP:0000171)1.63621377
133Aplasia involving bones of the upper limbs (HP:0009823)1.63600490
134Aplasia of the phalanges of the hand (HP:0009802)1.63600490
135Aplasia involving bones of the extremities (HP:0009825)1.63600490
136Renovascular hypertension (HP:0100817)1.63384119
137Poor eye contact (HP:0000817)1.63179307
138Hypoalphalipoproteinemia (HP:0003233)1.63146157
139Urinary bladder sphincter dysfunction (HP:0002839)1.62681648
140Bowel incontinence (HP:0002607)1.62643577
141Decreased motor nerve conduction velocity (HP:0003431)1.62296812
142Germ cell neoplasia (HP:0100728)1.61219118
143Broad face (HP:0000283)1.60760434
144Elfin facies (HP:0004428)1.59681521
145Abnormality of the salivary glands (HP:0010286)1.59061172
146Impaired pain sensation (HP:0007328)1.58976600
147Abnormality of pain sensation (HP:0010832)1.58976600
148Round ear (HP:0100830)1.57888056
149Ventricular tachycardia (HP:0004756)1.55083396
150Advanced eruption of teeth (HP:0006288)1.54391700
151Pterygium (HP:0001059)1.54165403
152Obsessive-compulsive behavior (HP:0000722)1.53799776
153Abnormality of the phalanges of the hallux (HP:0010057)1.53311845
154Ulnar bowing (HP:0003031)1.52702866
155Arterial tortuosity (HP:0005116)1.52423875
156Abnormal atrioventricular conduction (HP:0005150)1.52193119
157Arnold-Chiari malformation (HP:0002308)1.51272552
158Scapular winging (HP:0003691)1.51215056
159Abnormal large intestine physiology (HP:0012700)1.51140638
160Distal arthrogryposis (HP:0005684)1.50698344
161Abnormality of the calf musculature (HP:0001430)1.49837039
162Abnormality of the calcaneus (HP:0008364)1.49209972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.84798981
2CDK123.15786526
3MAP3K92.72860869
4PKN22.57387811
5KSR22.32999886
6NTRK12.25489985
7NTRK32.22637354
8EPHA22.20215937
9PRKD32.11546945
10RIPK12.06424139
11PDGFRA1.96138787
12PHKG11.92294922
13PHKG21.92294922
14TTN1.91471308
15MAP3K21.89094775
16PAK61.86298618
17MAP2K41.75221268
18ERN11.69988571
19MAP3K41.68202110
20MET1.60979218
21CAMKK11.58740339
22RET1.56025041
23LATS21.55638996
24LMTK21.52173697
25TYRO31.49601717
26MINK11.48478741
27DAPK21.46879880
28SMG11.42996653
29ICK1.40215996
30SCYL21.39908991
31SIK11.36256353
32MARK11.36101419
33DDR21.35675865
34STK381.32695347
35MST1R1.32431827
36EIF2AK11.27834322
37PTK61.26661306
38PAK31.19970852
39RPS6KB21.15337284
40PRKCH1.11549684
41NEK11.09865761
42WNK41.08717478
43ALK1.08571435
44BMX1.07547642
45TAOK11.05893605
46UHMK11.03148190
47CAMK1G1.02112098
48PTK21.01401745
49BCKDK1.00544313
50WNK10.99938223
51MAP3K10.99868024
52ARAF0.98446896
53PNCK0.97558141
54FER0.96577909
55INSRR0.95782496
56PIK3CA0.95530570
57PINK10.93620893
58MAP3K70.93419755
59PDK40.90856021
60PDK30.90856021
61AKT20.88725627
62EPHA40.88455766
63GRK50.88414351
64NEK60.87818265
65CDK50.86813284
66CAMK2B0.86028190
67PDPK10.81231713
68DMPK0.80920468
69MAPKAPK30.79810987
70CDC42BPA0.78247834
71CASK0.77301931
72NTRK20.76919878
73IRAK30.76032695
74TESK10.75740097
75PRKD10.74526781
76CAMK1D0.74030479
77STK110.73071074
78BRD40.72237105
79CDK150.71094651
80SIK20.70542214
81SGK2230.70541516
82SGK4940.70541516
83MAP2K10.69812617
84CDK180.69420888
85MAP3K100.68156668
86FGFR30.68021664
87EEF2K0.66894711
88PDK10.65451710
89SGK20.63425984
90MAPK100.63068424
91HIPK20.62874056
92KSR10.62498902
93CDK11A0.62070984
94FRK0.61646193
95PRKAA10.60822533
96MARK20.60708163
97PDGFRB0.60461082
98EPHB20.59542841
99CAMKK20.58649638
100BRSK10.58540420
101EPHB10.58293501
102LATS10.57581463
103SGK30.57124474
104PRKD20.56643415
105LRRK20.56387061
106DYRK1B0.56182282
107TTK0.55714232
108CDK70.55046463
109STK38L0.54960578
110MTOR0.54609355
111JAK20.53678831
112PAK20.52737411
113RPS6KB10.52521642
114FGFR20.51520051
115MAP3K60.50666003
116FGFR40.50123023
117PRPF4B0.49835584
118ROCK20.48491545
119PDK20.47963394
120RPS6KA20.47522021
121PTK2B0.47435920
122PBK0.46955570
123STK240.46394379
124ROCK10.46124521
125FGFR10.46107410
126RAF10.44783358
127MAPK120.44640532
128RPS6KA30.43820449
129BRAF0.43765602
130DAPK30.43743969
131STK390.43079541
132CDK140.42823926
133PRKCZ0.42798016
134PRKACG0.42463972
135OBSCN0.42281602
136MOS0.41904279
137SGK10.41848391
138PRKCG0.39322905
139CAMK2D0.37917413
140CAMK2G0.37703681
141GSK3A0.37189024
142LIMK10.36755444
143CAMK2A0.36608793

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.31604842
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28658553
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96724032
4Arginine biosynthesis_Homo sapiens_hsa002201.88110336
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87349028
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67212316
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62747754
8Synaptic vesicle cycle_Homo sapiens_hsa047211.55825443
9Butanoate metabolism_Homo sapiens_hsa006501.51572178
10Adherens junction_Homo sapiens_hsa045201.50112656
11Bile secretion_Homo sapiens_hsa049761.47087378
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.43984029
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43156044
14Insulin secretion_Homo sapiens_hsa049111.42804865
15Thyroid cancer_Homo sapiens_hsa052161.41097991
16Fatty acid degradation_Homo sapiens_hsa000711.40520425
17Type II diabetes mellitus_Homo sapiens_hsa049301.37181202
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36394660
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34183779
20Fatty acid metabolism_Homo sapiens_hsa012121.29583015
21Vitamin B6 metabolism_Homo sapiens_hsa007501.25373139
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24367916
23GABAergic synapse_Homo sapiens_hsa047271.24294303
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23875618
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.23355921
26Tight junction_Homo sapiens_hsa045301.19616481
27Gastric acid secretion_Homo sapiens_hsa049711.17781129
28Propanoate metabolism_Homo sapiens_hsa006401.17540273
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15195872
30Tryptophan metabolism_Homo sapiens_hsa003801.13752718
31Long-term potentiation_Homo sapiens_hsa047201.12714967
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09109574
33PPAR signaling pathway_Homo sapiens_hsa033201.07105983
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06529433
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.05981869
36Non-small cell lung cancer_Homo sapiens_hsa052231.04495137
37Circadian entrainment_Homo sapiens_hsa047131.03470026
38Fatty acid biosynthesis_Homo sapiens_hsa000611.03190567
39Chronic myeloid leukemia_Homo sapiens_hsa052201.01581095
40ECM-receptor interaction_Homo sapiens_hsa045120.98531592
41Dorso-ventral axis formation_Homo sapiens_hsa043200.97984398
42Salivary secretion_Homo sapiens_hsa049700.97847814
43Dopaminergic synapse_Homo sapiens_hsa047280.97108343
44mTOR signaling pathway_Homo sapiens_hsa041500.96888180
45Renin secretion_Homo sapiens_hsa049240.96876731
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96510417
47Olfactory transduction_Homo sapiens_hsa047400.96345427
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94804894
49Insulin signaling pathway_Homo sapiens_hsa049100.94662163
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93941426
51Hippo signaling pathway_Homo sapiens_hsa043900.93828710
52Dilated cardiomyopathy_Homo sapiens_hsa054140.93792286
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93247857
54Estrogen signaling pathway_Homo sapiens_hsa049150.92508058
55Cholinergic synapse_Homo sapiens_hsa047250.92417290
56Glucagon signaling pathway_Homo sapiens_hsa049220.91860271
57GnRH signaling pathway_Homo sapiens_hsa049120.91221587
58Glioma_Homo sapiens_hsa052140.90763824
59Circadian rhythm_Homo sapiens_hsa047100.88692968
60Proteoglycans in cancer_Homo sapiens_hsa052050.88459221
61Choline metabolism in cancer_Homo sapiens_hsa052310.87794096
62Glutamatergic synapse_Homo sapiens_hsa047240.87693714
63Arginine and proline metabolism_Homo sapiens_hsa003300.87208042
64Insulin resistance_Homo sapiens_hsa049310.86978688
65Phenylalanine metabolism_Homo sapiens_hsa003600.86588068
66Amphetamine addiction_Homo sapiens_hsa050310.86434797
67Axon guidance_Homo sapiens_hsa043600.84758180
68Oxytocin signaling pathway_Homo sapiens_hsa049210.84565897
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84342815
70Fructose and mannose metabolism_Homo sapiens_hsa000510.83616969
71Gap junction_Homo sapiens_hsa045400.83587312
72Vibrio cholerae infection_Homo sapiens_hsa051100.83101495
73Cocaine addiction_Homo sapiens_hsa050300.82584193
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81160789
75Oocyte meiosis_Homo sapiens_hsa041140.80874892
76Starch and sucrose metabolism_Homo sapiens_hsa005000.79913140
77Carbon metabolism_Homo sapiens_hsa012000.79665354
78Pyruvate metabolism_Homo sapiens_hsa006200.78379972
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.77816858
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.75883247
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75569344
82Pancreatic cancer_Homo sapiens_hsa052120.75393957
83Morphine addiction_Homo sapiens_hsa050320.74930230
84AMPK signaling pathway_Homo sapiens_hsa041520.73555773
85MicroRNAs in cancer_Homo sapiens_hsa052060.73182980
86Pancreatic secretion_Homo sapiens_hsa049720.73022142
87Fat digestion and absorption_Homo sapiens_hsa049750.72645421
88Prostate cancer_Homo sapiens_hsa052150.71908135
89Thyroid hormone synthesis_Homo sapiens_hsa049180.71171903
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69737352
91Prion diseases_Homo sapiens_hsa050200.69261416
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68648187
93VEGF signaling pathway_Homo sapiens_hsa043700.67849725
94Inositol phosphate metabolism_Homo sapiens_hsa005620.67179446
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65314042
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65233657
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63922677
98Biosynthesis of amino acids_Homo sapiens_hsa012300.63591618
99Notch signaling pathway_Homo sapiens_hsa043300.63497162
100Nicotine addiction_Homo sapiens_hsa050330.63173722
101Pentose phosphate pathway_Homo sapiens_hsa000300.63138711
102Long-term depression_Homo sapiens_hsa047300.62686874
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62005583
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61321474
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61174950
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.60978401
107Glycerolipid metabolism_Homo sapiens_hsa005610.60843533
108cAMP signaling pathway_Homo sapiens_hsa040240.60066108
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60045173
110Lysine degradation_Homo sapiens_hsa003100.57992403
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.57598134
112Wnt signaling pathway_Homo sapiens_hsa043100.57506855
113Focal adhesion_Homo sapiens_hsa045100.56098625
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55958735
115Complement and coagulation cascades_Homo sapiens_hsa046100.55378237
116Cardiac muscle contraction_Homo sapiens_hsa042600.55332538
117Sulfur metabolism_Homo sapiens_hsa009200.55107548
118ErbB signaling pathway_Homo sapiens_hsa040120.54386369
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54201683
120Endometrial cancer_Homo sapiens_hsa052130.54019555
121Small cell lung cancer_Homo sapiens_hsa052220.53837223
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52595972
123Taste transduction_Homo sapiens_hsa047420.52185397
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.52135243
125Calcium signaling pathway_Homo sapiens_hsa040200.51975773
126Melanogenesis_Homo sapiens_hsa049160.51779556
127beta-Alanine metabolism_Homo sapiens_hsa004100.51320202
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51306348
129Renal cell carcinoma_Homo sapiens_hsa052110.51041425
130Melanoma_Homo sapiens_hsa052180.50095782
131Lysosome_Homo sapiens_hsa041420.49480654
132Bladder cancer_Homo sapiens_hsa052190.47041453

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