VARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by virus of host process (GO:0019054)5.50598915
2poly(A)+ mRNA export from nucleus (GO:0016973)4.93840194
3ribosomal small subunit biogenesis (GO:0042274)4.91290037
4modulation by symbiont of host cellular process (GO:0044068)4.53873397
5alpha-linolenic acid metabolic process (GO:0036109)4.41035460
6protein carboxylation (GO:0018214)4.31163284
7peptidyl-glutamic acid carboxylation (GO:0017187)4.31163284
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21489610
9L-phenylalanine metabolic process (GO:0006558)4.21489610
10lysine catabolic process (GO:0006554)4.15533924
11lysine metabolic process (GO:0006553)4.15533924
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.08607626
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05683683
14regulation of cholesterol homeostasis (GO:2000188)3.95426780
15L-phenylalanine catabolic process (GO:0006559)3.94659761
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.94659761
17kynurenine metabolic process (GO:0070189)3.86252382
18glycine metabolic process (GO:0006544)3.84607425
19* regulation of translational fidelity (GO:0006450)3.75809405
20positive regulation of synapse maturation (GO:0090129)3.74255739
21activation of Rac GTPase activity (GO:0032863)3.64047788
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.62970394
23protein-DNA complex disassembly (GO:0032986)3.61080426
24nucleosome disassembly (GO:0006337)3.61080426
25modulation by virus of host morphology or physiology (GO:0019048)3.60822630
26positive regulation of histone deacetylation (GO:0031065)3.60368559
27sulfur amino acid catabolic process (GO:0000098)3.59940946
282-oxoglutarate metabolic process (GO:0006103)3.59336306
29regulation of cholesterol biosynthetic process (GO:0045540)3.56319070
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.52963629
31viral transcription (GO:0019083)3.52425059
32glyoxylate metabolic process (GO:0046487)3.51165674
33urea cycle (GO:0000050)3.48520188
34urea metabolic process (GO:0019627)3.48520188
35mitotic chromosome condensation (GO:0007076)3.47072962
36regulation of fatty acid beta-oxidation (GO:0031998)3.46052238
37cysteine metabolic process (GO:0006534)3.45659785
38convergent extension (GO:0060026)3.44660154
39negative regulation of viral release from host cell (GO:1902187)3.36093891
40aromatic amino acid family catabolic process (GO:0009074)3.34774500
41serine family amino acid catabolic process (GO:0009071)3.33516332
42positive regulation of fatty acid beta-oxidation (GO:0032000)3.33207983
43regulation of hippo signaling (GO:0035330)3.33022906
44proline biosynthetic process (GO:0006561)3.31685131
45negative regulation of cholesterol transport (GO:0032375)3.29638088
46negative regulation of sterol transport (GO:0032372)3.29638088
47cell-cell junction maintenance (GO:0045217)3.29124501
48peptidyl-arginine omega-N-methylation (GO:0035247)3.28561880
49pre-miRNA processing (GO:0031054)3.27525850
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.25487928
51aspartate family amino acid catabolic process (GO:0009068)3.24955207
52folic acid-containing compound biosynthetic process (GO:0009396)3.24504465
53lung epithelium development (GO:0060428)3.24264981
54negative regulation of fibrinolysis (GO:0051918)3.23176298
55maternal placenta development (GO:0001893)3.22468641
56cell migration in hindbrain (GO:0021535)3.20758701
57carnitine shuttle (GO:0006853)3.20563542
58peptidyl-lysine dimethylation (GO:0018027)3.20035674
59translational termination (GO:0006415)3.17582809
60cellular modified amino acid catabolic process (GO:0042219)3.15516395
61mannose metabolic process (GO:0006013)3.14665450
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14177133
63fatty acid transmembrane transport (GO:1902001)3.13687072
64amino-acid betaine metabolic process (GO:0006577)3.12951910
65dicarboxylic acid biosynthetic process (GO:0043650)3.12361633
66nitrogen cycle metabolic process (GO:0071941)3.12358501
67ethanol oxidation (GO:0006069)3.10514405
68fatty acid beta-oxidation (GO:0006635)3.09706183
69regulation of protein activation cascade (GO:2000257)3.09574197
70pentose-phosphate shunt (GO:0006098)3.09232408
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05718652
72bile acid biosynthetic process (GO:0006699)3.05137855
73negative regulation of cell size (GO:0045792)3.04779232
74serine family amino acid metabolic process (GO:0009069)3.03706029
75acetyl-CoA metabolic process (GO:0006084)3.03353241
76semaphorin-plexin signaling pathway (GO:0071526)3.03032278
77negative regulation of fatty acid biosynthetic process (GO:0045717)3.03002265
78complement activation, alternative pathway (GO:0006957)3.02150024
79homocysteine metabolic process (GO:0050667)3.01795662
80cellular response to epidermal growth factor stimulus (GO:0071364)3.00272761
81regulation of histone H3-K27 methylation (GO:0061085)2.98895102
82layer formation in cerebral cortex (GO:0021819)2.98552644
83positive regulation of fatty acid oxidation (GO:0046321)2.98361027
84ribosomal small subunit assembly (GO:0000028)2.97392856
85tryptophan catabolic process (GO:0006569)2.93033283
86indole-containing compound catabolic process (GO:0042436)2.93033283
87indolalkylamine catabolic process (GO:0046218)2.93033283
88regulation of complement activation (GO:0030449)2.92793901
89regulation of chromatin binding (GO:0035561)2.92198478
90positive regulation of gene expression, epigenetic (GO:0045815)2.91320310
914-hydroxyproline metabolic process (GO:0019471)2.89603891
92maturation of SSU-rRNA (GO:0030490)2.88207635
93regulation of RNA export from nucleus (GO:0046831)2.87137220
94DNA unwinding involved in DNA replication (GO:0006268)2.86872431
95regulation of fatty acid oxidation (GO:0046320)2.86429174
96G1 DNA damage checkpoint (GO:0044783)2.86337638
97alpha-amino acid catabolic process (GO:1901606)2.86148516
98protein insertion into membrane (GO:0051205)2.85811449
99spliceosomal tri-snRNP complex assembly (GO:0000244)2.84641996
100heterochromatin organization (GO:0070828)2.84238129
101focal adhesion assembly (GO:0048041)2.81646855
102cell-substrate adherens junction assembly (GO:0007045)2.81646855
103regulation of triglyceride catabolic process (GO:0010896)2.80240090
104serine family amino acid biosynthetic process (GO:0009070)2.79848140
105intracellular estrogen receptor signaling pathway (GO:0030520)2.79539797
106protein complex disassembly (GO:0043241)2.79232213
107oxaloacetate metabolic process (GO:0006107)2.78277326
108adherens junction assembly (GO:0034333)2.78145192
109regulation of fibrinolysis (GO:0051917)2.76619090
110negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75788232
111mRNA stabilization (GO:0048255)2.75074168
112RNA stabilization (GO:0043489)2.75074168
113biotin metabolic process (GO:0006768)2.74673083
114positive regulation of triglyceride biosynthetic process (GO:0010867)2.73831940
115regulation of synapse maturation (GO:0090128)2.73619606
116fatty acid oxidation (GO:0019395)2.72773458
117regulation of NFAT protein import into nucleus (GO:0051532)2.72126774
118negative regulation of fatty acid transport (GO:2000192)2.71984601
119glutamate metabolic process (GO:0006536)2.71686595
120translational elongation (GO:0006414)2.71343809
121regulation of nucleobase-containing compound transport (GO:0032239)2.70864686
122proline metabolic process (GO:0006560)2.70857278
123cellular amino acid catabolic process (GO:0009063)2.69973547
124plasma lipoprotein particle clearance (GO:0034381)2.69726353
125bile acid metabolic process (GO:0008206)2.69071646
126viral life cycle (GO:0019058)2.68046791
127one-carbon metabolic process (GO:0006730)2.68015568
128DNA replication initiation (GO:0006270)2.67719034
129mitotic G1 DNA damage checkpoint (GO:0031571)2.67334433
130mitochondrion transport along microtubule (GO:0047497)2.67317398
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67317398
132tryptophan metabolic process (GO:0006568)2.67208662
133regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.66641094
134apoptotic process involved in morphogenesis (GO:0060561)2.66526373
135neural tube development (GO:0021915)2.66503052
136NADPH regeneration (GO:0006740)2.66456849
137establishment of apical/basal cell polarity (GO:0035089)2.66320146
138histone H4 deacetylation (GO:0070933)2.64716484
139snRNA metabolic process (GO:0016073)2.64149282
140positive regulation of triglyceride metabolic process (GO:0090208)2.63512939
141DNA geometric change (GO:0032392)2.63232726
142regulation of ARF GTPase activity (GO:0032312)2.63212142
143imidazole-containing compound metabolic process (GO:0052803)2.62349420
144valine metabolic process (GO:0006573)2.61552166
145lipid oxidation (GO:0034440)2.61504975
146triglyceride homeostasis (GO:0070328)2.61485914
147acylglycerol homeostasis (GO:0055090)2.61485914
148fatty acid catabolic process (GO:0009062)2.61197048
149regulation of hydrogen peroxide metabolic process (GO:0010310)2.60806852
150short-chain fatty acid metabolic process (GO:0046459)2.60113877
151regulation of cholesterol metabolic process (GO:0090181)2.59916166
152cellular protein complex disassembly (GO:0043624)2.59891499
153tricarboxylic acid metabolic process (GO:0072350)2.59863582
154negative regulation of fatty acid metabolic process (GO:0045922)2.59822607
155retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59710920
156negative regulation of histone methylation (GO:0031061)2.59602870
157response to laminar fluid shear stress (GO:0034616)2.59090794
158regulation of gene silencing by RNA (GO:0060966)2.57988064
159regulation of posttranscriptional gene silencing (GO:0060147)2.57988064
160regulation of gene silencing by miRNA (GO:0060964)2.57988064
161regulation of glucose import in response to insulin stimulus (GO:2001273)2.56452007
162activation of MAPKKK activity (GO:0000185)2.55963696
163Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55547331
164DNA duplex unwinding (GO:0032508)2.55114605
165cochlea morphogenesis (GO:0090103)2.54845780
166response to epidermal growth factor (GO:0070849)2.54500136
167protein retention in ER lumen (GO:0006621)2.54255294
168regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52656233
169cell junction maintenance (GO:0034331)2.51612306
170stress granule assembly (GO:0034063)2.50007179
171plasma lipoprotein particle assembly (GO:0034377)2.49947457
172synaptic vesicle docking involved in exocytosis (GO:0016081)2.48453503
173peptidyl-arginine methylation (GO:0018216)2.48038331
174peptidyl-arginine N-methylation (GO:0035246)2.48038331
175basement membrane organization (GO:0071711)2.47508541
176negative regulation of erythrocyte differentiation (GO:0045647)2.47471445
177histone arginine methylation (GO:0034969)2.47356012
178negative regulation of catenin import into nucleus (GO:0035414)2.46609373
179retrograde transport, endosome to Golgi (GO:0042147)2.46195440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.99587063
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.68174249
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.29237814
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27788294
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.17150764
6MYC_22102868_ChIP-Seq_BL_Human3.11215525
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.79258315
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46119068
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.39437300
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33856213
11VDR_21846776_ChIP-Seq_THP-1_Human2.23459792
12ZNF263_19887448_ChIP-Seq_K562_Human2.22466304
13* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14683222
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09803469
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07564080
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.04556421
17KDM2B_26808549_Chip-Seq_DND41_Human1.99736358
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.93104309
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92934714
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92252315
21LXR_22292898_ChIP-Seq_THP-1_Human1.91695913
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90780875
23TCF7_22412390_ChIP-Seq_EML_Mouse1.90580971
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.88181930
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.87947632
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84272654
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81658047
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.81597324
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80976827
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74205260
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71967752
32SMC4_20622854_ChIP-Seq_HELA_Human1.69963211
33RACK7_27058665_Chip-Seq_MCF-7_Human1.64426396
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61625774
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60555141
36CLOCK_20551151_ChIP-Seq_293T_Human1.58562416
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56186630
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53771663
39* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51655515
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50734666
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50116289
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49060879
43UTX_26944678_Chip-Seq_JUKART_Human1.47896680
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47791666
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47638155
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46467683
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45462421
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45144283
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44545324
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.43272339
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42766614
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42118964
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41899393
54CTCF_27219007_Chip-Seq_Bcells_Human1.41106476
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.41030947
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40725895
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.39540238
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35082066
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34120981
60P68_20966046_ChIP-Seq_HELA_Human1.31774732
61ATF3_27146783_Chip-Seq_COLON_Human1.31602710
62MAF_26560356_Chip-Seq_TH1_Human1.31217920
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29292933
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.29252719
65CREB1_26743006_Chip-Seq_LNCaP_Human1.27918918
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27878942
67PHF8_20622854_ChIP-Seq_HELA_Human1.26159048
68* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25911312
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24582540
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24363228
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24193379
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24173782
73RARA_24833708_ChIP-Seq_LIVER_Mouse1.23608599
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21773985
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21245857
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20325468
77KDM2B_26808549_Chip-Seq_K562_Human1.20281009
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20152010
79BCOR_27268052_Chip-Seq_Bcells_Human1.19654483
80* FOXP1_21924763_ChIP-Seq_HESCs_Human1.19302097
81ETS1_21867929_ChIP-Seq_TH2_Mouse1.18554662
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17798128
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17797524
84BCL6_27268052_Chip-Seq_Bcells_Human1.16204500
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15925609
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15646990
87RARB_24833708_ChIP-Seq_LIVER_Mouse1.14846600
88E2F1_20622854_ChIP-Seq_HELA_Human1.14232487
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14153182
90* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13231844
91NCOR1_26117541_ChIP-Seq_K562_Human1.12739135
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12166881
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10848075
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10392082
95SA1_27219007_Chip-Seq_Bcells_Human1.09328916
96CIITA_25753668_ChIP-Seq_RAJI_Human1.09149912
97XRN2_22483619_ChIP-Seq_HELA_Human1.09039823
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.08814480
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08458543
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08439277
101* CTCF_26484167_Chip-Seq_Bcells_Mouse1.07859710
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07536078
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07274641
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07274641
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07274641
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06507424
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.05345703
108* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04864283
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04525646
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04251982
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.03924268
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03823780
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02818743
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02164887
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02134898
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01482542
117DROSHA_22980978_ChIP-Seq_HELA_Human1.00923646
118TP53_22127205_ChIP-Seq_IMR90_Human1.00905551
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.00861222
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.00754111
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.00008661
122SCL_19346495_ChIP-Seq_HPC-7_Human0.98792395
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98613819
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.98266467
125* CTCF_21964334_Chip-Seq_Bcells_Human0.98064513
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96970376
127* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96822718
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96333594
129GATA6_25053715_ChIP-Seq_YYC3_Human0.96070300
130AR_21909140_ChIP-Seq_LNCAP_Human0.95787538
131VDR_24763502_ChIP-Seq_THP-1_Human0.94466985
132* MAF_26560356_Chip-Seq_TH2_Human0.94159119
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92920692
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92763995
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92719904
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92487316
137E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92422052
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91742547
139TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91149872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.59477287
2MP0002139_abnormal_hepatobiliary_system4.43910095
3MP0003705_abnormal_hypodermis_morpholog4.11466845
4MP0000566_synostosis4.06474719
5MP0005085_abnormal_gallbladder_physiolo3.84952512
6MP0005365_abnormal_bile_salt3.52187729
7MP0004858_abnormal_nervous_system2.67905123
8MP0002249_abnormal_larynx_morphology2.59726369
9MP0009840_abnormal_foam_cell2.54373513
10MP0003806_abnormal_nucleotide_metabolis2.46643870
11MP0010329_abnormal_lipoprotein_level2.40044876
12MP0005083_abnormal_biliary_tract2.37438175
13MP0003123_paternal_imprinting2.33355652
14MP0003252_abnormal_bile_duct2.28842796
15MP0004185_abnormal_adipocyte_glucose2.27231689
16MP0004859_abnormal_synaptic_plasticity2.21499975
17MP0005058_abnormal_lysosome_morphology2.16705810
18MP0005451_abnormal_body_composition2.16615137
19MP0001348_abnormal_lacrimal_gland2.14803504
20MP0003329_amyloid_beta_deposits2.12665212
21MP0008875_abnormal_xenobiotic_pharmacok2.12513150
22MP0008961_abnormal_basal_metabolism2.10052007
23MP0003172_abnormal_lysosome_physiology2.06334741
24MP0000678_abnormal_parathyroid_gland2.04672900
25MP0009379_abnormal_foot_pigmentation2.04161309
26MP0010352_gastrointestinal_tract_polyps1.93353546
27MP0005409_darkened_coat_color1.92144615
28MP0001666_abnormal_nutrient_absorption1.90441080
29MP0005171_absent_coat_pigmentation1.82696560
30MP0005076_abnormal_cell_differentiation1.81722726
31MP0000609_abnormal_liver_physiology1.74949706
32MP0003136_yellow_coat_color1.68495366
33MP0005666_abnormal_adipose_tissue1.66699668
34MP0003566_abnormal_cell_adhesion1.59940154
35MP0005332_abnormal_amino_acid1.54916714
36MP0003122_maternal_imprinting1.54879359
37MP0004130_abnormal_muscle_cell1.50718999
38MP0005423_abnormal_somatic_nervous1.49288114
39MP0003191_abnormal_cellular_cholesterol1.44908256
40MP0001730_embryonic_growth_arrest1.43964372
41MP0010234_abnormal_vibrissa_follicle1.38693622
42MP0003693_abnormal_embryo_hatching1.38106331
43MP0003942_abnormal_urinary_system1.38084317
44MP0009278_abnormal_bone_marrow1.37141364
45MP0004957_abnormal_blastocyst_morpholog1.35389444
46MP0005375_adipose_tissue_phenotype1.32088287
47MP0002118_abnormal_lipid_homeostasis1.30680692
48MP0010630_abnormal_cardiac_muscle1.26503097
49MP0005623_abnormal_meninges_morphology1.24769614
50MP0004197_abnormal_fetal_growth/weight/1.24010682
51MP0003861_abnormal_nervous_system1.22844540
52MP0002116_abnormal_craniofacial_bone1.22435410
53MP0000955_abnormal_spinal_cord1.21274158
54MP0003300_gastrointestinal_ulcer1.20071800
55MP0002932_abnormal_joint_morphology1.18028812
56MP0003111_abnormal_nucleus_morphology1.17941099
57MP0005319_abnormal_enzyme/_coenzyme1.17856296
58MP0001672_abnormal_embryogenesis/_devel1.17147792
59MP0005380_embryogenesis_phenotype1.17147792
60MP0001502_abnormal_circadian_rhythm1.16120101
61MP0004087_abnormal_muscle_fiber1.15530974
62MP0005670_abnormal_white_adipose1.15506832
63MP0009384_cardiac_valve_regurgitation1.15208077
64MP0002086_abnormal_extraembryonic_tissu1.14875926
65MP0002697_abnormal_eye_size1.14090861
66MP0000733_abnormal_muscle_development1.13593425
67MP0005023_abnormal_wound_healing1.13371433
68MP0001346_abnormal_lacrimal_gland1.12664287
69MP0001849_ear_inflammation1.12056371
70MP0004808_abnormal_hematopoietic_stem1.11583854
71MP0003283_abnormal_digestive_organ1.10905847
72MP0002088_abnormal_embryonic_growth/wei1.10836385
73MP0003984_embryonic_growth_retardation1.09970733
74MP0003634_abnormal_glial_cell1.09584701
75MP0004133_heterotaxia1.09279122
76MP0002269_muscular_atrophy1.08177517
77MP0003077_abnormal_cell_cycle1.08061219
78MP0000598_abnormal_liver_morphology1.06499572
79MP0001697_abnormal_embryo_size1.04635538
80MP0006054_spinal_hemorrhage1.04480850
81MP0000490_abnormal_crypts_of1.02854168
82MP0000003_abnormal_adipose_tissue1.02316885
83MP0003879_abnormal_hair_cell1.02055014
84MP0000778_abnormal_nervous_system1.00483222
85MP0002080_prenatal_lethality0.99975136
86MP0003115_abnormal_respiratory_system0.99971071
87MP0002084_abnormal_developmental_patter0.99762349
88MP0008057_abnormal_DNA_replication0.98963384
89MP0005257_abnormal_intraocular_pressure0.98328925
90MP0000350_abnormal_cell_proliferation0.96852823
91MP0003938_abnormal_ear_development0.96658832
92MP0009672_abnormal_birth_weight0.96619260
93MP0002092_abnormal_eye_morphology0.96570916
94MP0002111_abnormal_tail_morphology0.96335451
95MP0008775_abnormal_heart_ventricle0.94392679
96MP0003385_abnormal_body_wall0.93905626
97MP0008569_lethality_at_weaning0.93822842
98MP0002970_abnormal_white_adipose0.93215217
99MP0004270_analgesia0.93029212
100MP0001958_emphysema0.92498075
101MP0010307_abnormal_tumor_latency0.91908111
102MP0003635_abnormal_synaptic_transmissio0.91395031
103MP0002114_abnormal_axial_skeleton0.91286356
104MP0000751_myopathy0.91106059
105MP0002060_abnormal_skin_morphology0.90898334
106MP0002152_abnormal_brain_morphology0.90767927
107MP0005330_cardiomyopathy0.90216245
108MP0002822_catalepsy0.89862688
109MP0002063_abnormal_learning/memory/cond0.89443308
110MP0005584_abnormal_enzyme/coenzyme_acti0.89077920
111MP0002796_impaired_skin_barrier0.89000865
112MP0002085_abnormal_embryonic_tissue0.88381075
113MP0002128_abnormal_blood_circulation0.88018563
114MP0000477_abnormal_intestine_morphology0.87345408
115MP0000747_muscle_weakness0.85679458
116MP0003878_abnormal_ear_physiology0.84559153
117MP0005377_hearing/vestibular/ear_phenot0.84559153
118MP0004084_abnormal_cardiac_muscle0.84199973
119MP0001270_distended_abdomen0.84196288
120MP0004381_abnormal_hair_follicle0.84150560
121MP0001915_intracranial_hemorrhage0.83764848
122MP0004742_abnormal_vestibular_system0.83529363
123MP0001299_abnormal_eye_distance/0.83432067
124MP0000534_abnormal_ureter_morphology0.83247705
125MP0010030_abnormal_orbit_morphology0.82996991
126MP0003279_aneurysm0.82878244
127MP0002837_dystrophic_cardiac_calcinosis0.82143850
128MP0006138_congestive_heart_failure0.81411862
129MP0003567_abnormal_fetal_cardiomyocyte0.81261512
130MP0000266_abnormal_heart_morphology0.80363308
131MP0000703_abnormal_thymus_morphology0.80087507
132MP0003119_abnormal_digestive_system0.79869509
133MP0010094_abnormal_chromosome_stability0.79547699
134MP0003453_abnormal_keratinocyte_physiol0.79422765
135MP0002396_abnormal_hematopoietic_system0.78365071
136MP0010368_abnormal_lymphatic_system0.77650532
137MP0000537_abnormal_urethra_morphology0.76731736
138MP0009643_abnormal_urine_homeostasis0.76687870
139MP0002234_abnormal_pharynx_morphology0.76441966
140MP0004233_abnormal_muscle_weight0.76221990
141MP0003868_abnormal_feces_composition0.76216583
142MP0003221_abnormal_cardiomyocyte_apopto0.76182477
143MP0000428_abnormal_craniofacial_morphol0.75862768
144MP0003315_abnormal_perineum_morphology0.75575479
145MP0009053_abnormal_anal_canal0.74671128
146MP0000467_abnormal_esophagus_morphology0.74239988
147MP0002971_abnormal_brown_adipose0.73144367
148MP0005501_abnormal_skin_physiology0.72617330
149MP0002019_abnormal_tumor_incidence0.71416418
150MP0008770_decreased_survivor_rate0.71165997
151MP0002089_abnormal_postnatal_growth/wei0.71141596
152MP0009703_decreased_birth_body0.70368229
153MP0005220_abnormal_exocrine_pancreas0.69283650
154MP0008932_abnormal_embryonic_tissue0.69016713
155MP0003763_abnormal_thymus_physiology0.68792084
156MP0002075_abnormal_coat/hair_pigmentati0.68766261
157MP0001661_extended_life_span0.66924792

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.27849461
2Hyperlipoproteinemia (HP:0010980)3.92959568
3Intrahepatic cholestasis (HP:0001406)3.56638816
4Xanthomatosis (HP:0000991)3.44994161
5Obstructive sleep apnea (HP:0002870)3.32692040
6Hyperacusis (HP:0010780)3.24378619
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.15938408
8Joint hemorrhage (HP:0005261)3.14936064
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.13677327
10Prolonged partial thromboplastin time (HP:0003645)3.12492908
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11300018
12Ketosis (HP:0001946)3.09056604
13Broad face (HP:0000283)2.96694112
14Truncus arteriosus (HP:0001660)2.96058841
15Hyperammonemia (HP:0001987)2.93197962
16Spastic diplegia (HP:0001264)2.87986780
17Reticulocytopenia (HP:0001896)2.85370690
18Abnormality of the intrinsic pathway (HP:0010989)2.81702428
19Hypobetalipoproteinemia (HP:0003563)2.78569384
20Abnormality of the common coagulation pathway (HP:0010990)2.76882755
21Protrusio acetabuli (HP:0003179)2.76744193
22Pointed chin (HP:0000307)2.75818431
23Neurofibrillary tangles (HP:0002185)2.75495789
24Hemorrhage of the eye (HP:0011885)2.72941800
25Mask-like facies (HP:0000298)2.71278142
26Subacute progressive viral hepatitis (HP:0006572)2.70510722
27Abnormality of cochlea (HP:0000375)2.70408193
28Pseudobulbar signs (HP:0002200)2.70362172
29Flat acetabular roof (HP:0003180)2.64424689
30Hepatocellular carcinoma (HP:0001402)2.63476456
31Renovascular hypertension (HP:0100817)2.62748948
32Abnormality of reticulocytes (HP:0004312)2.61171966
33Hyperglycinuria (HP:0003108)2.60078038
3411 pairs of ribs (HP:0000878)2.59468159
35Abnormality of serine family amino acid metabolism (HP:0010894)2.58360574
36Abnormality of glycine metabolism (HP:0010895)2.58360574
37Annular pancreas (HP:0001734)2.57268855
38Hyperglycinemia (HP:0002154)2.56986814
39Broad metatarsal (HP:0001783)2.55655726
40Ketoacidosis (HP:0001993)2.54519556
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.51497180
42Abnormality of the lower motor neuron (HP:0002366)2.51265506
43Morphological abnormality of the inner ear (HP:0011390)2.49717528
44Reticulocytosis (HP:0001923)2.49709412
45Abnormality of the Achilles tendon (HP:0005109)2.47102112
46Cerebral aneurysm (HP:0004944)2.46328896
47Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.43260008
48Absent epiphyses (HP:0010577)2.43260008
49Complement deficiency (HP:0004431)2.42214515
50Abnormality of the fingertips (HP:0001211)2.41337019
51Disproportionate tall stature (HP:0001519)2.38184117
52Bowel incontinence (HP:0002607)2.37974379
53Cerebral inclusion bodies (HP:0100314)2.36357722
54Insomnia (HP:0100785)2.35872001
55Ependymoma (HP:0002888)2.31268442
56Broad palm (HP:0001169)2.29488370
57Dysmetric saccades (HP:0000641)2.28623890
58Thin ribs (HP:0000883)2.28502594
59Intestinal fistula (HP:0100819)2.27888390
60Broad distal phalanx of finger (HP:0009836)2.27720683
61Elfin facies (HP:0004428)2.27337601
62Bowel diverticulosis (HP:0005222)2.26319919
63Vertebral arch anomaly (HP:0008438)2.23879531
64Metaphyseal cupping (HP:0003021)2.23872028
65Lymphangioma (HP:0100764)2.22969882
66Myocardial infarction (HP:0001658)2.22554690
67Biconcave vertebral bodies (HP:0004586)2.22246922
68Turricephaly (HP:0000262)2.21755710
69Abnormal large intestine physiology (HP:0012700)2.19725674
70Achilles tendon contracture (HP:0001771)2.18233936
71Hypolipoproteinemia (HP:0010981)2.18008393
72Trigonocephaly (HP:0000243)2.17548397
73Abnormal cartilage morphology (HP:0002763)2.17351305
74Vaginal fistula (HP:0004320)2.16889294
75Partial duplication of thumb phalanx (HP:0009944)2.14705687
76Abnormality of sulfur amino acid metabolism (HP:0004339)2.13408022
77Right ventricular cardiomyopathy (HP:0011663)2.12642513
78Increased connective tissue (HP:0009025)2.12630557
79Axonal loss (HP:0003447)2.09793822
80Hypoglycemic coma (HP:0001325)2.08673987
81Personality changes (HP:0000751)2.08372299
82Adenoma sebaceum (HP:0009720)2.06925141
83Angiofibromas (HP:0010615)2.06925141
84Enlarged penis (HP:0000040)2.05728119
85Aplasia involving bones of the upper limbs (HP:0009823)2.05130029
86Aplasia of the phalanges of the hand (HP:0009802)2.05130029
87Aplasia involving bones of the extremities (HP:0009825)2.05130029
88Abnormality of the thoracic spine (HP:0100711)2.04428783
89Fibroma (HP:0010614)2.04391011
90Choanal stenosis (HP:0000452)2.04333450
91Hypoalphalipoproteinemia (HP:0003233)2.04041335
92Flat cornea (HP:0007720)2.03714138
93Rectal prolapse (HP:0002035)2.02946945
94Increased nuchal translucency (HP:0010880)2.02802032
95Myoglobinuria (HP:0002913)2.02729684
96Ankle contracture (HP:0006466)2.02662929
97Thin bony cortex (HP:0002753)2.01448078
98Myopathic facies (HP:0002058)2.01016599
99Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00872206
100Deep palmar crease (HP:0006191)1.99833691
101Hypercholesterolemia (HP:0003124)1.98135370
102Selective tooth agenesis (HP:0001592)1.98030708
103Ulnar bowing (HP:0003031)1.97622725
104Hyperthyroidism (HP:0000836)1.97366504
105High anterior hairline (HP:0009890)1.97060686
106Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96872281
107Abnormality of the calcaneus (HP:0008364)1.95228956
108Multiple enchondromatosis (HP:0005701)1.93958229
109Upper motor neuron abnormality (HP:0002127)1.93613670
110Abnormality of pyrimidine metabolism (HP:0004353)1.93582520
111Gout (HP:0001997)1.92562294
112Abnormality of complement system (HP:0005339)1.91734473
113Abnormality of the aortic arch (HP:0012303)1.91309478
114Esophageal varix (HP:0002040)1.91129662
115Long palpebral fissure (HP:0000637)1.89949888
116Shallow orbits (HP:0000586)1.89530143
117Fibrous tissue neoplasm (HP:0012316)1.88877109
118Duplication of thumb phalanx (HP:0009942)1.88665107
119Renal duplication (HP:0000075)1.88245107
120Aneurysm (HP:0002617)1.87127061
121Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86484818
122Mitral regurgitation (HP:0001653)1.86069416
123Upper limb amyotrophy (HP:0009129)1.84643393
124Distal upper limb amyotrophy (HP:0007149)1.84643393
125Mitral valve prolapse (HP:0001634)1.84539422
126Abnormality of endocrine pancreas physiology (HP:0012093)1.83197098
127Abnormality of the pancreatic islet cells (HP:0006476)1.83197098
128Basal cell carcinoma (HP:0002671)1.82750826
129Spina bifida occulta (HP:0003298)1.82681091
130Thoracic kyphosis (HP:0002942)1.82189252
131Rib fusion (HP:0000902)1.82026991
132Cupped ribs (HP:0000887)1.81788187
133Abnormality of cells of the erythroid lineage (HP:0012130)1.81712013
134Neoplasm of striated muscle (HP:0009728)1.81529202
135Atelectasis (HP:0100750)1.81388448
136Colitis (HP:0002583)1.80975698
137Epidermoid cyst (HP:0200040)1.80858647
138Bladder diverticulum (HP:0000015)1.79061897
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.76888021
140Astrocytoma (HP:0009592)1.76453185
141Abnormality of the astrocytes (HP:0100707)1.76453185
142Abnormal number of incisors (HP:0011064)1.76379312
143Overriding aorta (HP:0002623)1.76333824
144Stridor (HP:0010307)1.76089399
145Arnold-Chiari malformation (HP:0002308)1.75458504
146Abnormality of the 4th metacarpal (HP:0010012)1.74949961
147Patellar dislocation (HP:0002999)1.73840953
148Abnormality of fatty-acid metabolism (HP:0004359)1.73250465
149Cholecystitis (HP:0001082)1.73249614
150Abnormal gallbladder physiology (HP:0012438)1.73249614
151Hand muscle atrophy (HP:0009130)1.72710759
152Skin tags (HP:0010609)1.72640101
153Increased mean platelet volume (HP:0011877)1.72006396
154Progressive muscle weakness (HP:0003323)1.71954009
155Abnormality of nucleobase metabolism (HP:0010932)1.71808848
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71757665
157Peripheral hypomyelination (HP:0007182)1.71318531
158Rhabdomyolysis (HP:0003201)1.70869744
159Dislocated radial head (HP:0003083)1.69953066
160Partial duplication of the phalanx of hand (HP:0009999)1.69738118
161Bronchomalacia (HP:0002780)1.69068517
162Exercise-induced myalgia (HP:0003738)1.68603260
163Hyporeflexia of lower limbs (HP:0002600)1.68475350
164Poikiloderma (HP:0001029)1.68190695
165Impaired platelet aggregation (HP:0003540)1.67474386
166Abnormal platelet function (HP:0011869)1.67474386
167Abnormality of carpal bone ossification (HP:0006257)1.67301847
168Sudden death (HP:0001699)1.66793763
169Small epiphyses (HP:0010585)1.66746230
170Self-mutilation (HP:0000742)1.66438300
171Premature skin wrinkling (HP:0100678)1.65879046
172Abnormality of the radial head (HP:0003995)1.65726575
173Abnormal platelet volume (HP:0011876)1.65164360
174Broad thumb (HP:0011304)1.64812227
175Neonatal onset (HP:0003623)1.64781303
176Urethral obstruction (HP:0000796)1.64543621
177Abnormal ossification of hand bones (HP:0005921)1.64295980
178Supernumerary nipples (HP:0002558)1.63784595
179Abnormality of purine metabolism (HP:0004352)1.60922012
180Ectopia lentis (HP:0001083)1.60287275
181Skin nodule (HP:0200036)1.59673452
182High pitched voice (HP:0001620)1.59230537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.73362880
2PKN24.69555838
3EEF2K3.86405416
4SMG13.62003483
5MAP3K103.51550859
6CDK122.79355957
7PDGFRA2.17636294
8ERN12.16329967
9BCKDK2.11415750
10PRPF4B2.05370577
11ICK2.03324712
12TTN2.01450923
13SIK11.89270305
14FGFR41.74122611
15MAP4K11.72972355
16PTK61.66313294
17NEK21.65616414
18BMX1.64141321
19TAOK11.57893130
20RPS6KB21.48179761
21IRAK31.46846738
22MAP3K71.45293257
23MAP3K131.44846241
24MTOR1.42078223
25LRRK21.38599628
26TAOK21.32925649
27GRK61.32607732
28CDK41.30138672
29STK101.22214479
30MAP2K61.20649193
31FLT31.19472065
32TYRO31.17691141
33WNK41.16832822
34NTRK11.16235840
35KSR21.15859907
36NTRK21.10813817
37SCYL21.10058816
38RIPK11.09579821
39CAMKK11.05266521
40PAK41.02902102
41LATS11.02483905
42NTRK31.02366306
43PDGFRB0.94901641
44NEK10.94040719
45SIK20.93175643
46CDK60.92251626
47MAP3K110.92004966
48BRD40.91540532
49NME20.90341054
50ALK0.90034246
51MAP3K80.89516285
52EPHA20.88061689
53AKT20.86742572
54NME10.84863249
55MAP2K20.84187251
56MST1R0.82836527
57MAPK120.82191713
58MAPK110.80718447
59CDK70.80528831
60PIM10.78163655
61TNK20.76075505
62PAK20.75602558
63RET0.73986769
64FGFR20.73926839
65ZAP700.70932938
66NEK90.70020778
67FGFR30.69591733
68PRKD20.68329465
69TLK10.68318312
70LMTK20.68012696
71PDPK10.67880788
72CHEK20.66494021
73TGFBR10.66262873
74ILK0.65248808
75CAMK1D0.65134919
76TTK0.64958993
77FGFR10.64714463
78ARAF0.64023991
79TESK20.63413695
80EPHB10.62720377
81LATS20.62297751
82CDC70.61409610
83CDK11A0.60143567
84MAP3K90.59793871
85RPS6KC10.59169261
86RPS6KL10.59169261
87TYK20.58935209
88RPS6KA60.58568125
89PRKD10.58037135
90MAPKAPK30.56844557
91DAPK20.56645112
92PTK20.56192383
93WNK10.55700693
94PRKCI0.55194488
95CDK150.54990375
96EIF2AK10.54610404
97BRAF0.53172467
98KSR10.52985074
99AURKA0.52657298
100MAPKAPK50.52088333
101CAMK1G0.52045342
102TGFBR20.51447827
103MAP2K30.50474508
104CCNB10.50430373
105PASK0.50235491
106JAK20.49249480
107CHEK10.48466733
108RAF10.46411910
109CSK0.45836801
110STK110.45800656
111PHKG20.44791033
112PHKG10.44791033
113RPS6KA10.44673782
114ATR0.44079436
115STK40.43412738
116RPS6KA20.43402505
117CDK10.42953879
118MARK20.42776520
119CDK180.42721155
120PRKAA10.42375591
121CDC42BPA0.42249357
122PRKCH0.41300094
123CSF1R0.40930864
124MAPK150.40461478
125EPHA40.40369535
126MAPK100.40292127
127CHUK0.40002762
128MAP3K10.39863509
129MAP3K60.39805929
130DDR20.39121512
131PAK60.39035392
132CDK20.38814914
133PDK10.37726478
134CDK90.37525963
135DMPK0.37209854
136PRKD30.36516532
137HIPK20.35629164
138DYRK1B0.35607393
139GSK3A0.35455471
140CSNK1D0.35185790
141ERBB20.35169217
142CAMK40.34737011
143GSK3B0.32866166

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.65728595
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.03835145
3Nitrogen metabolism_Homo sapiens_hsa009102.84303770
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66531360
5Arginine biosynthesis_Homo sapiens_hsa002202.60416367
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56777428
7Fatty acid degradation_Homo sapiens_hsa000712.56597720
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49425645
9Other glycan degradation_Homo sapiens_hsa005112.43589038
10Lysine degradation_Homo sapiens_hsa003102.42171265
11Tryptophan metabolism_Homo sapiens_hsa003802.10702904
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07488612
13Sulfur relay system_Homo sapiens_hsa041222.07126146
14Fatty acid metabolism_Homo sapiens_hsa012121.91984411
15Biosynthesis of amino acids_Homo sapiens_hsa012301.91368693
16PPAR signaling pathway_Homo sapiens_hsa033201.82284120
17Selenocompound metabolism_Homo sapiens_hsa004501.81036510
18Propanoate metabolism_Homo sapiens_hsa006401.72966787
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.72925931
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72612640
21Carbon metabolism_Homo sapiens_hsa012001.71690901
22One carbon pool by folate_Homo sapiens_hsa006701.67725169
23Caffeine metabolism_Homo sapiens_hsa002321.63625176
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58209720
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57918448
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54516755
27Complement and coagulation cascades_Homo sapiens_hsa046101.53131972
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.52832097
29Bile secretion_Homo sapiens_hsa049761.46836352
30Ribosome_Homo sapiens_hsa030101.38638227
31ErbB signaling pathway_Homo sapiens_hsa040121.36907131
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.27411806
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26265403
34Butanoate metabolism_Homo sapiens_hsa006501.20160512
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20028537
36Pyruvate metabolism_Homo sapiens_hsa006201.19663889
37Choline metabolism in cancer_Homo sapiens_hsa052311.18544834
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.18017917
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.14125903
40Vitamin B6 metabolism_Homo sapiens_hsa007501.10609743
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09714135
42Folate biosynthesis_Homo sapiens_hsa007901.09365041
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09141292
44GnRH signaling pathway_Homo sapiens_hsa049121.09047446
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.08490769
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05867808
47beta-Alanine metabolism_Homo sapiens_hsa004100.98629292
48Insulin resistance_Homo sapiens_hsa049310.98155683
49Pentose phosphate pathway_Homo sapiens_hsa000300.98118118
50Bladder cancer_Homo sapiens_hsa052190.97776118
51Peroxisome_Homo sapiens_hsa041460.97705210
52Fat digestion and absorption_Homo sapiens_hsa049750.97346356
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96794197
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.96629539
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96579939
56Fatty acid biosynthesis_Homo sapiens_hsa000610.92342174
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.90586805
58Starch and sucrose metabolism_Homo sapiens_hsa005000.89637670
59Chronic myeloid leukemia_Homo sapiens_hsa052200.89535421
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.84741283
61ABC transporters_Homo sapiens_hsa020100.82577193
62Non-small cell lung cancer_Homo sapiens_hsa052230.82198594
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.78301702
64Spliceosome_Homo sapiens_hsa030400.78235985
65DNA replication_Homo sapiens_hsa030300.76613459
66Histidine metabolism_Homo sapiens_hsa003400.76339228
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75436046
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73927673
69mTOR signaling pathway_Homo sapiens_hsa041500.73673139
70Arginine and proline metabolism_Homo sapiens_hsa003300.72699402
71Acute myeloid leukemia_Homo sapiens_hsa052210.72369782
72Long-term potentiation_Homo sapiens_hsa047200.71054568
73Chemical carcinogenesis_Homo sapiens_hsa052040.70887411
74Phenylalanine metabolism_Homo sapiens_hsa003600.70700198
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69724876
76Insulin signaling pathway_Homo sapiens_hsa049100.67794246
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67074881
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66833510
79AMPK signaling pathway_Homo sapiens_hsa041520.66392498
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66183259
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64997562
82Inositol phosphate metabolism_Homo sapiens_hsa005620.63901658
83Small cell lung cancer_Homo sapiens_hsa052220.63792809
84Alcoholism_Homo sapiens_hsa050340.63509596
85Renal cell carcinoma_Homo sapiens_hsa052110.62934289
86Glycerolipid metabolism_Homo sapiens_hsa005610.62689902
87Axon guidance_Homo sapiens_hsa043600.62588135
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61638998
89Prostate cancer_Homo sapiens_hsa052150.61262771
90Viral carcinogenesis_Homo sapiens_hsa052030.60764066
91Wnt signaling pathway_Homo sapiens_hsa043100.60015234
92Glucagon signaling pathway_Homo sapiens_hsa049220.59685523
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57929804
94Notch signaling pathway_Homo sapiens_hsa043300.57188809
95Cell cycle_Homo sapiens_hsa041100.56116296
96Hippo signaling pathway_Homo sapiens_hsa043900.55433799
97Fructose and mannose metabolism_Homo sapiens_hsa000510.55424190
98Melanogenesis_Homo sapiens_hsa049160.55267304
99Staphylococcus aureus infection_Homo sapiens_hsa051500.54560847
100Mismatch repair_Homo sapiens_hsa034300.54518264
101VEGF signaling pathway_Homo sapiens_hsa043700.53317391
102Systemic lupus erythematosus_Homo sapiens_hsa053220.51710964
103Nucleotide excision repair_Homo sapiens_hsa034200.51328939
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50035952
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50032213
106Thyroid cancer_Homo sapiens_hsa052160.47715661
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47117402
108Endometrial cancer_Homo sapiens_hsa052130.47023438
109Glioma_Homo sapiens_hsa052140.46398586
110* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45825578
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44294864
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43914398
113Galactose metabolism_Homo sapiens_hsa000520.43814796
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42982043
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42240095
116Thyroid hormone synthesis_Homo sapiens_hsa049180.42188971
117N-Glycan biosynthesis_Homo sapiens_hsa005100.42027776
118MAPK signaling pathway_Homo sapiens_hsa040100.41323377
119Prolactin signaling pathway_Homo sapiens_hsa049170.40717488
120Tyrosine metabolism_Homo sapiens_hsa003500.39527590
121MicroRNAs in cancer_Homo sapiens_hsa052060.39444472
122Proteoglycans in cancer_Homo sapiens_hsa052050.39216899
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39007822
124Focal adhesion_Homo sapiens_hsa045100.38694673
125B cell receptor signaling pathway_Homo sapiens_hsa046620.35268156
126Prion diseases_Homo sapiens_hsa050200.34771057
127mRNA surveillance pathway_Homo sapiens_hsa030150.33879970
128Dorso-ventral axis formation_Homo sapiens_hsa043200.31302046
129Pancreatic cancer_Homo sapiens_hsa052120.31157604
130Base excision repair_Homo sapiens_hsa034100.30857076
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.30117020
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29925041
133HTLV-I infection_Homo sapiens_hsa051660.29196100
134Retinol metabolism_Homo sapiens_hsa008300.28825565
135Basal cell carcinoma_Homo sapiens_hsa052170.28731953
136Glutathione metabolism_Homo sapiens_hsa004800.25315478
137Adherens junction_Homo sapiens_hsa045200.25309864
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23224967
139Dilated cardiomyopathy_Homo sapiens_hsa054140.23040808
140Estrogen signaling pathway_Homo sapiens_hsa049150.22584543
141RNA transport_Homo sapiens_hsa030130.22259942
142Colorectal cancer_Homo sapiens_hsa052100.22072378

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