VASP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87302599
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87302599
3detection of other organism (GO:0098543)4.70001527
4leukocyte aggregation (GO:0070486)4.65079242
5positive regulation of gamma-delta T cell activation (GO:0046645)4.54598214
6detection of bacterium (GO:0016045)4.50162352
7antigen processing and presentation of endogenous antigen (GO:0019883)4.47583116
8detection of external biotic stimulus (GO:0098581)4.05328159
9detection of molecule of bacterial origin (GO:0032490)3.96591794
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.82011319
11negative regulation of cell killing (GO:0031342)3.73357484
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.73357484
13positive regulation by symbiont of host defense response (GO:0052509)3.67753464
14modulation by symbiont of host defense response (GO:0052031)3.67753464
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67753464
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67753464
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.67753464
18modulation by symbiont of host immune response (GO:0052553)3.67753464
19regulation of gamma-delta T cell differentiation (GO:0045586)3.61468385
20positive thymic T cell selection (GO:0045059)3.59128953
21regulation of mast cell degranulation (GO:0043304)3.58138445
22detection of biotic stimulus (GO:0009595)3.54743753
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53472043
24negative regulation of erythrocyte differentiation (GO:0045647)3.50247760
25regulation of gamma-delta T cell activation (GO:0046643)3.48835163
26negative regulation of interleukin-12 production (GO:0032695)3.47633430
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.45186622
28germinal center formation (GO:0002467)3.45001187
29leukocyte migration involved in inflammatory response (GO:0002523)3.39302334
30regulation of leukocyte degranulation (GO:0043300)3.36383042
31regulation of B cell receptor signaling pathway (GO:0050855)3.34424737
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.33084048
33regulation of myeloid leukocyte mediated immunity (GO:0002886)3.32368722
34myeloid cell activation involved in immune response (GO:0002275)3.28541647
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27546192
36regulation of mast cell activation involved in immune response (GO:0033006)3.24057501
37negative regulation of leukocyte mediated immunity (GO:0002704)3.21685205
38macrophage activation (GO:0042116)3.19871175
39leukocyte cell-cell adhesion (GO:0007159)3.17568663
40cellular extravasation (GO:0045123)3.15495623
41NIK/NF-kappaB signaling (GO:0038061)3.12181056
42response to peptidoglycan (GO:0032494)3.12034048
43immunoglobulin mediated immune response (GO:0016064)3.06261108
44regulation of T-helper 2 cell differentiation (GO:0045628)3.05648026
45microglial cell activation (GO:0001774)3.04662188
46production of molecular mediator involved in inflammatory response (GO:0002532)3.04210993
47negative regulation of T cell mediated immunity (GO:0002710)3.02840560
48tolerance induction (GO:0002507)3.01859277
49regulation of T cell tolerance induction (GO:0002664)3.01716408
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01268073
51neutrophil mediated immunity (GO:0002446)3.00563236
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.00541640
53negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.99174534
54response to muramyl dipeptide (GO:0032495)2.99030425
55hepatocyte apoptotic process (GO:0097284)2.97794341
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96579219
57positive regulation of mast cell activation (GO:0033005)2.92757161
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92528057
59thymic T cell selection (GO:0045061)2.92222838
60defense response to protozoan (GO:0042832)2.91702529
61positive regulation of histone deacetylation (GO:0031065)2.90427906
62negative thymic T cell selection (GO:0045060)2.90203561
63regulation of tolerance induction (GO:0002643)2.89436499
64negative regulation of phagocytosis (GO:0050765)2.88608062
65negative regulation of cytokine production involved in immune response (GO:0002719)2.88336081
66regulation of mast cell activation (GO:0033003)2.86753928
67cellular response to interleukin-15 (GO:0071350)2.85661859
68response to laminar fluid shear stress (GO:0034616)2.84119609
69positive regulation of cellular amide metabolic process (GO:0034250)2.84098466
70negative T cell selection (GO:0043383)2.83539433
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82752232
72regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82483421
73regulation of interferon-beta biosynthetic process (GO:0045357)2.80606090
74regulation of regulated secretory pathway (GO:1903305)2.78528224
75respiratory burst (GO:0045730)2.77587144
76leukocyte degranulation (GO:0043299)2.76722544
77T cell migration (GO:0072678)2.74416914
78negative regulation of interleukin-6 production (GO:0032715)2.72689425
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72442829
80neutrophil activation involved in immune response (GO:0002283)2.72014155
81negative regulation of toll-like receptor signaling pathway (GO:0034122)2.68478302
82regulation of B cell differentiation (GO:0045577)2.67966634
83antigen processing and presentation via MHC class Ib (GO:0002475)2.66911003
84T-helper 1 type immune response (GO:0042088)2.66475991
85myeloid leukocyte activation (GO:0002274)2.66124787
86morphogenesis of an endothelium (GO:0003159)2.66069034
87endothelial tube morphogenesis (GO:0061154)2.66069034
88negative regulation of innate immune response (GO:0045824)2.65581614
89B cell receptor signaling pathway (GO:0050853)2.65334653
90positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.63561175
91response to fungus (GO:0009620)2.63359022
92neutrophil chemotaxis (GO:0030593)2.62864606
93T cell apoptotic process (GO:0070231)2.62743444
94response to interleukin-15 (GO:0070672)2.62534333
95regulation of podosome assembly (GO:0071801)2.62318456
96actin nucleation (GO:0045010)2.61552093
97B cell mediated immunity (GO:0019724)2.60385405
98regulation of natural killer cell mediated immunity (GO:0002715)2.59594600
99positive regulation of B cell differentiation (GO:0045579)2.59055393
100positive regulation of interferon-alpha production (GO:0032727)2.57811716
1013-UTR-mediated mRNA stabilization (GO:0070935)2.57341119
102neutrophil activation (GO:0042119)2.56487561
103response to host (GO:0075136)2.56311679
104response to host defenses (GO:0052200)2.56311679
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56311679
106regulation of response to interferon-gamma (GO:0060330)2.55456271
107positive T cell selection (GO:0043368)2.54580997
108positive regulation of lamellipodium assembly (GO:0010592)2.53259719
109response to host immune response (GO:0052572)2.53077626
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53077626
111defense response to fungus (GO:0050832)2.51797017
112regulation of interferon-alpha production (GO:0032647)2.51472318
113granulocyte activation (GO:0036230)2.51236708
114T cell selection (GO:0045058)2.50056567
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.47611978
116macrophage activation involved in immune response (GO:0002281)2.46656958
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43541706
118apoptotic process involved in morphogenesis (GO:0060561)2.43527050
119interferon-gamma-mediated signaling pathway (GO:0060333)2.41537387
120positive regulation of isotype switching (GO:0045830)2.40769511
121response to type I interferon (GO:0034340)2.39776390
122regulation of protein heterodimerization activity (GO:0043497)2.39699264
123interferon-gamma production (GO:0032609)2.38860365
124myeloid dendritic cell differentiation (GO:0043011)2.38691627
125positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37115551
126positive regulation of tolerance induction (GO:0002645)2.35672956
127establishment of endothelial barrier (GO:0061028)2.35570468
128type I interferon signaling pathway (GO:0060337)2.33316957
129cellular response to type I interferon (GO:0071357)2.33316957
130positive regulation of protein deacetylation (GO:0090312)2.32213699
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31807650
132lymphocyte apoptotic process (GO:0070227)2.31650235
133myeloid dendritic cell activation (GO:0001773)2.31394514
134T cell costimulation (GO:0031295)2.30439411
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30021179
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29748476
137response to protozoan (GO:0001562)2.28950635
138natural killer cell differentiation (GO:0001779)2.27459057
139positive regulation of chemokine biosynthetic process (GO:0045080)2.25474857
140regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.25424661
141positive regulation of lamellipodium organization (GO:1902745)2.25139787
142lymphocyte costimulation (GO:0031294)2.24993207
143negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.24860671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.85877960
2E2F7_22180533_ChIP-Seq_HELA_Human3.61824871
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16335046
4MYC_22102868_ChIP-Seq_BL_Human3.16006213
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03795059
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.94964125
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94877247
8VDR_21846776_ChIP-Seq_THP-1_Human2.70815974
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.68200308
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57864368
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.55395599
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42533745
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.42283258
14MAF_26560356_Chip-Seq_TH1_Human2.28601296
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19669968
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14473711
17TCF7_22412390_ChIP-Seq_EML_Mouse2.10667255
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10039330
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07542279
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07128534
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.06446588
22MYB_26560356_Chip-Seq_TH2_Human2.02542059
23* UTX_26944678_Chip-Seq_JUKART_Human2.02529428
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01165942
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00416424
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.97011351
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96785601
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92225099
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90805571
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.90791004
31VDR_24763502_ChIP-Seq_THP-1_Human1.90397740
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89324043
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87360052
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84031471
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81091747
36* MYB_26560356_Chip-Seq_TH1_Human1.80928988
37* SPI1_23547873_ChIP-Seq_NB4_Human1.80160476
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.79751208
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77946640
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75167208
41* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75041243
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.74868766
43KDM2B_26808549_Chip-Seq_DND41_Human1.74407750
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67688492
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66444324
46SCL_19346495_ChIP-Seq_HPC-7_Human1.65078085
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64936453
48RUNX_20019798_ChIP-Seq_JUKART_Human1.64008512
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63908443
50* MAF_26560356_Chip-Seq_TH2_Human1.48123750
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47959749
52* SPI1_23127762_ChIP-Seq_K562_Human1.44028706
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.41636275
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40156461
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38495371
56VDR_24787735_ChIP-Seq_THP-1_Human1.37910135
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28211349
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24180440
59* NCOR1_26117541_ChIP-Seq_K562_Human1.22747278
60LXR_22292898_ChIP-Seq_THP-1_Human1.22168762
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21240634
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20416853
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19270631
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19239073
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18299151
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.18114830
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.17282664
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14963238
69* ATF3_27146783_Chip-Seq_COLON_Human1.14722425
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14231048
71GATA3_27048872_Chip-Seq_THYMUS_Human1.12696802
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12681681
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12212570
74PU_27001747_Chip-Seq_BMDM_Mouse1.11942727
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11648092
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11554161
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.11105761
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10991337
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10813720
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09727123
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09366402
82GATA1_22025678_ChIP-Seq_K562_Human1.08136594
83CLOCK_20551151_ChIP-Seq_293T_Human1.07279386
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06892055
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06284012
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05585796
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05530674
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04570713
89BCOR_27268052_Chip-Seq_Bcells_Human1.03755670
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03735110
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03306454
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02840192
93KDM2B_26808549_Chip-Seq_K562_Human1.02784072
94BCL6_27268052_Chip-Seq_Bcells_Human1.00687113
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99724285
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99544571
97TFEB_21752829_ChIP-Seq_HELA_Human0.99158529
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98276491
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98213590
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.97705349
101MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95963937
102* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95619789
103MYC_18555785_ChIP-Seq_MESCs_Mouse0.95541416
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.94749362
105* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93094897
106GATA6_25053715_ChIP-Seq_YYC3_Human0.92837280
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.92274073
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90895849
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90582103
110* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90431284
111GATA2_19941826_ChIP-Seq_K562_Human0.89431349
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87326606
113CIITA_25753668_ChIP-Seq_RAJI_Human0.86797989
114ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86762887
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86346195
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86044329
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85899306
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85866447
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85376783
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85198018
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85025331
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85025331
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84898410
124GATA1_19941826_ChIP-Seq_K562_Human0.84703830
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84437658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.53706556
2MP0003436_decreased_susceptibility_to2.89033869
3MP0003300_gastrointestinal_ulcer2.74745620
4MP0001835_abnormal_antigen_presentation2.67113425
5MP0000685_abnormal_immune_system2.64674516
6MP0010352_gastrointestinal_tract_polyps2.52889697
7MP0009278_abnormal_bone_marrow2.50133419
8MP0009785_altered_susceptibility_to2.42758816
9MP0001800_abnormal_humoral_immune2.37761054
10MP0001790_abnormal_immune_system2.32641951
11MP0005387_immune_system_phenotype2.32641951
12MP0005451_abnormal_body_composition2.21626011
13MP0005000_abnormal_immune_tolerance2.21194978
14MP0002452_abnormal_antigen_presenting2.19391933
15MP0005025_abnormal_response_to2.09458365
16MP0005671_abnormal_response_to2.07187813
17MP0008260_abnormal_autophagy2.05708793
18MP0002405_respiratory_system_inflammati2.04435766
19MP0003705_abnormal_hypodermis_morpholog2.04003932
20MP0002420_abnormal_adaptive_immunity2.03380855
21MP0001819_abnormal_immune_cell2.02510078
22MP0002419_abnormal_innate_immunity2.01872212
23MP0002723_abnormal_immune_serum2.01864222
24MP0004947_skin_inflammation2.01606744
25MP0003763_abnormal_thymus_physiology2.00825055
26MP0003566_abnormal_cell_adhesion1.99517255
27MP0010155_abnormal_intestine_physiology1.94999213
28MP0005076_abnormal_cell_differentiation1.89663339
29* MP0002398_abnormal_bone_marrow1.86857402
30MP0009333_abnormal_splenocyte_physiolog1.85741664
31MP0001873_stomach_inflammation1.85154159
32MP0004510_myositis1.79426648
33MP0006082_CNS_inflammation1.74773886
34MP0002396_abnormal_hematopoietic_system1.73553276
35MP0004808_abnormal_hematopoietic_stem1.71889305
36MP0005397_hematopoietic_system_phenotyp1.69102385
37MP0001545_abnormal_hematopoietic_system1.69102385
38MP0000716_abnormal_immune_system1.66771371
39MP0005023_abnormal_wound_healing1.64188351
40MP0000858_altered_metastatic_potential1.61949086
41MP0002148_abnormal_hypersensitivity_rea1.61362712
42* MP0005464_abnormal_platelet_physiology1.59265130
43MP0000490_abnormal_crypts_of1.56999754
44MP0001533_abnormal_skeleton_physiology1.56932910
45MP0002722_abnormal_immune_system1.56819346
46MP0003448_altered_tumor_morphology1.55909980
47MP0000689_abnormal_spleen_morphology1.55097391
48MP0001845_abnormal_inflammatory_respons1.53605815
49MP0002166_altered_tumor_susceptibility1.53130890
50MP0003724_increased_susceptibility_to1.50313388
51MP0002429_abnormal_blood_cell1.46963479
52MP0003075_altered_response_to1.43236092
53MP0000465_gastrointestinal_hemorrhage1.42686919
54MP0010307_abnormal_tumor_latency1.41373892
55MP0003866_abnormal_defecation1.40696450
56MP0001853_heart_inflammation1.39922124
57MP0003453_abnormal_keratinocyte_physiol1.35843074
58MP0002132_abnormal_respiratory_system1.34154288
59MP0002006_tumorigenesis1.30789907
60MP0000703_abnormal_thymus_morphology1.29015052
61MP0002933_joint_inflammation1.27931592
62MP0010234_abnormal_vibrissa_follicle1.27472578
63MP0006054_spinal_hemorrhage1.20744758
64MP0004883_abnormal_blood_vessel1.19550297
65MP0005058_abnormal_lysosome_morphology1.19239912
66MP0000343_altered_response_to1.18752013
67MP0003091_abnormal_cell_migration1.16594163
68MP0005164_abnormal_response_to1.11685189
69MP0002877_abnormal_melanocyte_morpholog1.10702369
70MP0002254_reproductive_system_inflammat1.10535536
71MP0003183_abnormal_peptide_metabolism1.08466883
72MP0003693_abnormal_embryo_hatching1.06995238
73MP0008469_abnormal_protein_level1.02698588
74MP0008004_abnormal_stomach_pH1.01740715
75MP0003828_pulmonary_edema1.00135437
76MP0000604_amyloidosis0.98753413
77MP0004381_abnormal_hair_follicle0.98191509
78MP0002019_abnormal_tumor_incidence0.97951372
79MP0001851_eye_inflammation0.97760283
80MP0009840_abnormal_foam_cell0.97184767
81MP0003279_aneurysm0.96846279
82MP0002277_abnormal_respiratory_mucosa0.93989920
83MP0005310_abnormal_salivary_gland0.91579945
84MP0000733_abnormal_muscle_development0.91119632
85MP0003806_abnormal_nucleotide_metabolis0.89666848
86MP0001958_emphysema0.89447737
87MP0004957_abnormal_blastocyst_morpholog0.87188282
88MP0003191_abnormal_cellular_cholesterol0.86367528
89MP0003172_abnormal_lysosome_physiology0.86265109
90MP0003077_abnormal_cell_cycle0.86115535
91MP0002998_abnormal_bone_remodeling0.85814468
92MP0000477_abnormal_intestine_morphology0.85776351
93MP0004858_abnormal_nervous_system0.83896149
94MP0009763_increased_sensitivity_to0.82193441
95MP0000350_abnormal_cell_proliferation0.81671312
96MP0005390_skeleton_phenotype0.80729585
97MP0002086_abnormal_extraembryonic_tissu0.80614502
98MP0001663_abnormal_digestive_system0.79621796
99MP0005167_abnormal_blood-brain_barrier0.78682387
100MP0003656_abnormal_erythrocyte_physiolo0.78124823
101MP0001730_embryonic_growth_arrest0.76401190
102MP0003045_fibrosis0.76238413
103MP0003690_abnormal_glial_cell0.76043035
104MP0001849_ear_inflammation0.75377289
105MP0004185_abnormal_adipocyte_glucose0.74708727
106MP0003111_abnormal_nucleus_morphology0.74426213
107MP0009764_decreased_sensitivity_to0.73260002
108MP0001216_abnormal_epidermal_layer0.72760072
109MP0000767_abnormal_smooth_muscle0.72113352
110MP0000249_abnormal_blood_vessel0.71379331
111MP0004264_abnormal_extraembryonic_tissu0.71358643
112MP0002138_abnormal_hepatobiliary_system0.70476693
113MP0005166_decreased_susceptibility_to0.70017951
114MP0008438_abnormal_cutaneous_collagen0.67780979
115MP0003221_abnormal_cardiomyocyte_apopto0.66005752
116MP0003795_abnormal_bone_structure0.64982136
117MP0009931_abnormal_skin_appearance0.64720566
118MP0002925_abnormal_cardiovascular_devel0.64325199
119MP0008874_decreased_physiological_sensi0.62814153

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.14954401
2Recurrent abscess formation (HP:0002722)4.48885698
3Recurrent bacterial skin infections (HP:0005406)3.78049895
4Recurrent fungal infections (HP:0002841)3.52709789
5Pustule (HP:0200039)3.47263136
6Elevated erythrocyte sedimentation rate (HP:0003565)3.43276470
7Myositis (HP:0100614)3.30071548
8Cellulitis (HP:0100658)3.18051108
9Recurrent viral infections (HP:0004429)3.12079844
10Nasal polyposis (HP:0100582)3.09524612
11Increased density of long bones (HP:0006392)3.09101767
12Mediastinal lymphadenopathy (HP:0100721)3.07584678
13Interstitial pulmonary disease (HP:0006530)3.00853271
14Recurrent gram-negative bacterial infections (HP:0005420)2.99293989
15Keratoconjunctivitis sicca (HP:0001097)2.99024426
16Abnormality of macrophages (HP:0004311)2.96920233
17Abnormality of the nasal mucosa (HP:0000433)2.96147729
18Chronic otitis media (HP:0000389)2.95768815
19IgM deficiency (HP:0002850)2.89950757
20Autoimmune thrombocytopenia (HP:0001973)2.89624551
21Encephalitis (HP:0002383)2.89588110
22Stomatitis (HP:0010280)2.88625390
23Abnormality of liposaccharide metabolism (HP:0010968)2.84789433
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.84789433
25Abnormality of glycolipid metabolism (HP:0010969)2.84789433
26Chronic obstructive pulmonary disease (HP:0006510)2.75728721
27Obstructive lung disease (HP:0006536)2.75728721
28Recurrent bronchitis (HP:0002837)2.74758810
29Inflammation of the large intestine (HP:0002037)2.72933284
30Keratoconjunctivitis (HP:0001096)2.72249679
31Gastrointestinal inflammation (HP:0004386)2.71815366
32Spontaneous hematomas (HP:0007420)2.69528478
33Cerebral aneurysm (HP:0004944)2.67236370
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.64827531
35Amyloidosis (HP:0011034)2.63073366
36Orchitis (HP:0100796)2.60004409
37Hematochezia (HP:0002573)2.55162176
38Abnormal platelet volume (HP:0011876)2.52483393
39Recurrent skin infections (HP:0001581)2.52466273
40Gingivitis (HP:0000230)2.52372510
41Increased IgE level (HP:0003212)2.51530615
42Loss of speech (HP:0002371)2.47609579
43Colitis (HP:0002583)2.46035385
44Petechiae (HP:0000967)2.45585701
45Thrombocytosis (HP:0001894)2.45115797
46Episodic fever (HP:0001954)2.44120603
47T lymphocytopenia (HP:0005403)2.43895937
48Meningitis (HP:0001287)2.42799096
49Vasculitis (HP:0002633)2.42709024
50Hypochromic anemia (HP:0001931)2.42530857
51Abnormality of T cells (HP:0002843)2.39887677
52Abnormality of T cell number (HP:0011839)2.38503749
53Hypochromic microcytic anemia (HP:0004840)2.35522020
54Increased IgM level (HP:0003496)2.31502496
55Anorexia (HP:0002039)2.28284569
56Premature loss of primary teeth (HP:0006323)2.26823583
57Recurrent cutaneous fungal infections (HP:0011370)2.25234805
58Chronic mucocutaneous candidiasis (HP:0002728)2.25234805
59Abnormality of T cell physiology (HP:0011840)2.24435637
60Periodontitis (HP:0000704)2.22194427
61Arterial thrombosis (HP:0004420)2.22091727
62Increased serum ferritin (HP:0003281)2.20845251
63Ulnar bowing (HP:0003031)2.20729531
64Purpura (HP:0000979)2.19859913
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.18269623
66Urticaria (HP:0001025)2.17202638
67Leukocytosis (HP:0001974)2.16816023
68Pulmonary embolism (HP:0002204)2.16806203
69Hepatosplenomegaly (HP:0001433)2.16156996
70Increased mean platelet volume (HP:0011877)2.15983715
71Aortic aneurysm (HP:0004942)2.15109642
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.13773267
73Osteolytic defects of the hand bones (HP:0009699)2.11961692
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.11961692
75Dysostosis multiplex (HP:0000943)2.11798814
76Segmental peripheral demyelination/remyelination (HP:0003481)2.11563868
77Chest pain (HP:0100749)2.11230279
78Optic neuritis (HP:0100653)2.09932912
79Retrobulbar optic neuritis (HP:0100654)2.09932912
80Sepsis (HP:0100806)2.09804840
81Osteomyelitis (HP:0002754)2.09374063
82Verrucae (HP:0200043)2.09314422
83Papilloma (HP:0012740)2.09314422
84Lymphopenia (HP:0001888)2.08975990
85Emphysema (HP:0002097)2.08674766
86Skin ulcer (HP:0200042)2.08388304
87Peritonitis (HP:0002586)2.06771700
88Malnutrition (HP:0004395)2.04469386
89Glomerulopathy (HP:0100820)2.03841440
90Prolonged bleeding time (HP:0003010)2.02611840
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00414903
92Bicuspid aortic valve (HP:0001647)1.99659994
93Granulocytopenia (HP:0001913)1.97925233
94Systemic lupus erythematosus (HP:0002725)1.97602967
95Vacuolated lymphocytes (HP:0001922)1.96955926
96Persistence of primary teeth (HP:0006335)1.96901161
97Abnormal platelet function (HP:0011869)1.94436666
98Impaired platelet aggregation (HP:0003540)1.94436666
99Slow saccadic eye movements (HP:0000514)1.93009800
100Abnormality of iron homeostasis (HP:0011031)1.89804491
101Panhypogammaglobulinemia (HP:0003139)1.88731627
102Polygenic inheritance (HP:0010982)1.88332805
103Abnormality of the fingertips (HP:0001211)1.87846752
104Abnormality of the pleura (HP:0002103)1.86438116
105IgA deficiency (HP:0002720)1.84969887
106Microcytic anemia (HP:0001935)1.84836577
107Viral hepatitis (HP:0006562)1.84398530
108Gangrene (HP:0100758)1.83977451
109Protrusio acetabuli (HP:0003179)1.83812449
110Pulmonary infiltrates (HP:0002113)1.83668439
111Abnormality of the pericardium (HP:0001697)1.82845523
112Epistaxis (HP:0000421)1.81560764
113Gastrointestinal infarctions (HP:0005244)1.80922037
114Dilatation of the ascending aorta (HP:0005111)1.80888230
115Hemoptysis (HP:0002105)1.79567530
116Abnormality of the endocardium (HP:0004306)1.78346781
117Myocardial infarction (HP:0001658)1.78304466
118Gastrointestinal stroma tumor (HP:0100723)1.77980873
119Recurrent pneumonia (HP:0006532)1.76590123
120Subacute progressive viral hepatitis (HP:0006572)1.76561670
121Restrictive lung disease (HP:0002091)1.76051673
122Gingival bleeding (HP:0000225)1.74524173
123Fatigue (HP:0012378)1.73853474
124Aortic dissection (HP:0002647)1.72451824
125Cheilitis (HP:0100825)1.72357524
126Frequent falls (HP:0002359)1.72281237
127Eosinophilia (HP:0001880)1.71047437
128Combined immunodeficiency (HP:0005387)1.70717993
129Basal cell carcinoma (HP:0002671)1.69939728
130Polycythemia (HP:0001901)1.68319239
131Cervical subluxation (HP:0003308)1.66909207
132Mitral valve prolapse (HP:0001634)1.66710054
133Increased cerebral lipofuscin (HP:0011813)1.66040489
134Agammaglobulinemia (HP:0004432)1.65789019
135Radial bowing (HP:0002986)1.65374438
136Thin bony cortex (HP:0002753)1.62901845
137Abnormality of the peritoneum (HP:0002585)1.62889153
138Hypergammaglobulinemia (HP:0010702)1.62397006
139Hyperacusis (HP:0010780)1.59841464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.98141574
2TRIB33.11066071
3PRPF4B2.84619238
4PKN22.74227362
5STK102.69722546
6EEF2K2.61974658
7MAP3K102.61247948
8ERN12.43614638
9LRRK22.04868302
10JAK32.03154026
11TYK22.01100383
12EPHB11.95568069
13ZAP701.91935176
14GRK61.91801947
15BLK1.91370107
16TBK11.90376695
17TTN1.82398147
18CSK1.74807666
19SMG11.72392977
20TAOK21.71139154
21CDK121.67904333
22TXK1.66507273
23TNK21.61941059
24MAP3K141.61472269
25PTK61.60086177
26IRAK41.54917902
27BTK1.49056764
28MAP2K31.46234299
29RPS6KA41.42615062
30IKBKE1.40802637
31PAK41.40312702
32MAP3K11.38789731
33FGFR41.35760466
34SIK31.31885885
35TESK21.31857270
36ITK1.31407518
37MST41.30333058
38TGFBR21.29346778
39HCK1.22434564
40JAK11.21945537
41KDR1.18113753
42PIM11.16051900
43IKBKB1.15826359
44CSF1R1.14295949
45KIT1.11373003
46IRAK31.09090683
47RPS6KB21.07404925
48FGFR31.06701191
49BMX1.06262176
50NEK21.05377969
51RIPK11.05285506
52CDC42BPA1.04986810
53LCK1.03072234
54PRKD21.02579857
55TESK11.01933882
56MAP3K81.01534324
57MARK30.98832117
58IRAK20.98769642
59MAP3K110.97407701
60MAP3K30.94138279
61CHUK0.93882946
62FLT30.93439321
63YES10.92721410
64CLK10.91872262
65SYK0.91652404
66MARK20.91202418
67IRAK10.89177266
68PDPK10.86037872
69TRPM70.85059971
70FGR0.83746277
71PIM20.81921306
72CDK40.81246844
73NME20.79386511
74CDK60.79167635
75TEC0.78816804
76DMPK0.77185759
77RIPK40.76621089
78TAOK10.76550168
79PDK10.75730053
80EPHA20.75056347
81MAP3K60.74684082
82SCYL20.74009684
83BMPR20.72637821
84JAK20.72354922
85PTK20.65884599
86MATK0.65787478
87MAPKAPK30.64768906
88TGFBR10.64560216
89MAP2K20.63907657
90LYN0.62929055
91MAPKAPK20.61089109
92EPHA30.60612402
93SIK20.60527844
94MAP3K50.60170243
95PDGFRA0.59934907
96FES0.59326727
97STK40.55346112
98ILK0.54217141
99PAK20.52367815
100FYN0.51418648
101STK30.51026446
102RPS6KA60.50264817
103MTOR0.49608896
104MOS0.49580143
105MAP3K20.49395291
106MAPK120.49113154
107HIPK20.48998892
108PDGFRB0.48323207
109MAPK70.47535464
110SIK10.47125650
111RPS6KA20.46676164
112EGFR0.46663280
113RPS6KL10.45668080
114RPS6KC10.45668080
115PTK2B0.43867219
116NEK90.41511695
117MAP3K70.41029248
118NLK0.40950352
119MAP3K130.39655514
120RET0.39565880
121CDK190.38123344
122ABL10.37626798
123GRK70.37519245
124TAOK30.37136921
125ICK0.35883848
126STK380.35864848
127DYRK1B0.35856421
128MELK0.35708951
129KSR20.34620568
130CDK90.34473957
131STK240.34074769
132RAF10.32961593
133SGK30.32316614
134PIK3CG0.31720296

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.77357771
2Osteoclast differentiation_Homo sapiens_hsa043802.18939126
3B cell receptor signaling pathway_Homo sapiens_hsa046622.17812904
4Primary immunodeficiency_Homo sapiens_hsa053402.13322892
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.11651429
6Measles_Homo sapiens_hsa051621.85961880
7Antigen processing and presentation_Homo sapiens_hsa046121.85428013
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83462577
9Toxoplasmosis_Homo sapiens_hsa051451.75684829
10Shigellosis_Homo sapiens_hsa051311.74718532
11Hematopoietic cell lineage_Homo sapiens_hsa046401.73488659
12* Leukocyte transendothelial migration_Homo sapiens_hsa046701.70937934
13* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69734008
14Legionellosis_Homo sapiens_hsa051341.69553251
15T cell receptor signaling pathway_Homo sapiens_hsa046601.66154785
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63328399
17Chronic myeloid leukemia_Homo sapiens_hsa052201.61434799
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59161578
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56312970
20Acute myeloid leukemia_Homo sapiens_hsa052211.55712487
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.55593699
22TNF signaling pathway_Homo sapiens_hsa046681.51432133
23Apoptosis_Homo sapiens_hsa042101.48852485
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48605983
25Viral myocarditis_Homo sapiens_hsa054161.48570962
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48371734
27Herpes simplex infection_Homo sapiens_hsa051681.43845731
28Malaria_Homo sapiens_hsa051441.42643992
29Type I diabetes mellitus_Homo sapiens_hsa049401.41408270
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.39108757
31Tuberculosis_Homo sapiens_hsa051521.38258856
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36921050
33Hepatitis B_Homo sapiens_hsa051611.36717742
34Influenza A_Homo sapiens_hsa051641.36099959
35Pertussis_Homo sapiens_hsa051331.35985678
36Graft-versus-host disease_Homo sapiens_hsa053321.34240934
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33675879
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32804739
39Asthma_Homo sapiens_hsa053101.31835071
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31433869
41Salmonella infection_Homo sapiens_hsa051321.30240464
42Small cell lung cancer_Homo sapiens_hsa052221.30049380
43Staphylococcus aureus infection_Homo sapiens_hsa051501.29377942
44Pancreatic cancer_Homo sapiens_hsa052121.26753158
45Allograft rejection_Homo sapiens_hsa053301.19683732
46Chemokine signaling pathway_Homo sapiens_hsa040621.17882790
47Rheumatoid arthritis_Homo sapiens_hsa053231.13417341
48VEGF signaling pathway_Homo sapiens_hsa043701.12851427
49Viral carcinogenesis_Homo sapiens_hsa052031.08625977
50HTLV-I infection_Homo sapiens_hsa051661.02512572
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01451213
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.99931687
53Adherens junction_Homo sapiens_hsa045200.98405555
54Proteoglycans in cancer_Homo sapiens_hsa052050.98077252
55* Platelet activation_Homo sapiens_hsa046110.97192150
56Amoebiasis_Homo sapiens_hsa051460.96888347
57Epstein-Barr virus infection_Homo sapiens_hsa051690.96536708
58Notch signaling pathway_Homo sapiens_hsa043300.95709958
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95573330
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94544780
61MicroRNAs in cancer_Homo sapiens_hsa052060.94387443
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94154730
63Hepatitis C_Homo sapiens_hsa051600.93916421
64p53 signaling pathway_Homo sapiens_hsa041150.91380234
65Bladder cancer_Homo sapiens_hsa052190.90297408
66Colorectal cancer_Homo sapiens_hsa052100.89673921
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88038561
68Non-small cell lung cancer_Homo sapiens_hsa052230.83184570
69HIF-1 signaling pathway_Homo sapiens_hsa040660.82346055
70* Focal adhesion_Homo sapiens_hsa045100.82191454
71Prolactin signaling pathway_Homo sapiens_hsa049170.81942186
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81684569
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81462386
74Other glycan degradation_Homo sapiens_hsa005110.73667591
75mTOR signaling pathway_Homo sapiens_hsa041500.73121871
76Ribosome_Homo sapiens_hsa030100.70118738
77Renal cell carcinoma_Homo sapiens_hsa052110.69380894
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.69154824
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.66313472
80DNA replication_Homo sapiens_hsa030300.65938401
81Insulin resistance_Homo sapiens_hsa049310.64799061
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.63414889
83Endocytosis_Homo sapiens_hsa041440.61149386
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59526900
85Thyroid cancer_Homo sapiens_hsa052160.59139529
86Endometrial cancer_Homo sapiens_hsa052130.58741746
87GnRH signaling pathway_Homo sapiens_hsa049120.57979546
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.57703636
89Lysosome_Homo sapiens_hsa041420.57380033
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56734406
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56524105
92Pathways in cancer_Homo sapiens_hsa052000.55731805
93Prostate cancer_Homo sapiens_hsa052150.55360893
94Base excision repair_Homo sapiens_hsa034100.55202993
95Spliceosome_Homo sapiens_hsa030400.54357853
96African trypanosomiasis_Homo sapiens_hsa051430.52289724
97FoxO signaling pathway_Homo sapiens_hsa040680.50102418
98Cell cycle_Homo sapiens_hsa041100.49623356
99Choline metabolism in cancer_Homo sapiens_hsa052310.48994120
100Galactose metabolism_Homo sapiens_hsa000520.48963856
101Prion diseases_Homo sapiens_hsa050200.47576034
102ErbB signaling pathway_Homo sapiens_hsa040120.46975497
103Pentose phosphate pathway_Homo sapiens_hsa000300.46925769
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46279366
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44777830
106Autoimmune thyroid disease_Homo sapiens_hsa053200.44105111
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.43260690
108ECM-receptor interaction_Homo sapiens_hsa045120.43180042
109Insulin signaling pathway_Homo sapiens_hsa049100.42488201
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41840532
111Phagosome_Homo sapiens_hsa041450.41662381
112MAPK signaling pathway_Homo sapiens_hsa040100.40723817
113One carbon pool by folate_Homo sapiens_hsa006700.40149650
114RNA transport_Homo sapiens_hsa030130.40074579
115* Rap1 signaling pathway_Homo sapiens_hsa040150.40016112

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