VAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)4.58915357
2apoptotic cell clearance (GO:0043277)4.53098609
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.35841851
4cell adhesion mediated by integrin (GO:0033627)4.30640912
5low-density lipoprotein particle clearance (GO:0034383)4.16022421
6melanin biosynthetic process (GO:0042438)4.12175858
7basement membrane organization (GO:0071711)3.90684127
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.88423759
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.85006021
10negative regulation of fatty acid transport (GO:2000192)3.83121400
11endodermal cell differentiation (GO:0035987)3.82198959
12plasma membrane repair (GO:0001778)3.77087824
13protein heterotrimerization (GO:0070208)3.69285990
14regulation of early endosome to late endosome transport (GO:2000641)3.68468667
15positive regulation by symbiont of host defense response (GO:0052509)3.64657465
16modulation by symbiont of host defense response (GO:0052031)3.64657465
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64657465
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64657465
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.64657465
20modulation by symbiont of host immune response (GO:0052553)3.64657465
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.60370109
22skin morphogenesis (GO:0043589)3.59439072
23protein localization to endosome (GO:0036010)3.58827471
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.53600251
25protein maturation by protein folding (GO:0022417)3.49611572
26semaphorin-plexin signaling pathway (GO:0071526)3.43618491
27melanin metabolic process (GO:0006582)3.42722636
28neuron projection extension involved in neuron projection guidance (GO:1902284)3.40830882
29axon extension involved in axon guidance (GO:0048846)3.40830882
30retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39188327
31regulation of cholesterol storage (GO:0010885)3.37971975
32retina vasculature morphogenesis in camera-type eye (GO:0061299)3.33072295
33paraxial mesoderm development (GO:0048339)3.32518409
34positive regulation of p38MAPK cascade (GO:1900745)3.31907970
35wound healing, spreading of epidermal cells (GO:0035313)3.31793900
36stress fiber assembly (GO:0043149)3.29604933
37regulation of integrin activation (GO:0033623)3.26276910
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.24318158
39collagen fibril organization (GO:0030199)3.24110242
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22584457
41response to laminar fluid shear stress (GO:0034616)3.15044808
42chondrocyte proliferation (GO:0035988)3.14891312
43glucose 6-phosphate metabolic process (GO:0051156)3.14130198
44adhesion of symbiont to host (GO:0044406)3.12879048
45collagen metabolic process (GO:0032963)3.12144851
46collagen catabolic process (GO:0030574)3.11918989
47cell-substrate junction assembly (GO:0007044)3.10425064
48mannose metabolic process (GO:0006013)3.10161283
49secondary metabolite biosynthetic process (GO:0044550)3.09571972
50negative regulation of cell size (GO:0045792)3.09173123
51cytoskeletal anchoring at plasma membrane (GO:0007016)3.07996782
52epithelial cell-cell adhesion (GO:0090136)3.06995118
53protein hydroxylation (GO:0018126)3.05098824
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.04496496
55barbed-end actin filament capping (GO:0051016)3.03222852
56positive regulation of endothelial cell apoptotic process (GO:2000353)2.99649856
57axon extension (GO:0048675)2.98947866
58keratan sulfate catabolic process (GO:0042340)2.98180525
59multicellular organismal macromolecule metabolic process (GO:0044259)2.97710082
60L-alpha-amino acid transmembrane transport (GO:1902475)2.95814224
61extracellular matrix disassembly (GO:0022617)2.94303604
62adhesion of symbiont to host cell (GO:0044650)2.94200414
63virion attachment to host cell (GO:0019062)2.94200414
64regulation of interferon-beta biosynthetic process (GO:0045357)2.93464486
65multicellular organismal catabolic process (GO:0044243)2.92310418
66cortical actin cytoskeleton organization (GO:0030866)2.91334458
67positive regulation of nuclease activity (GO:0032075)2.90663031
68endothelial cell morphogenesis (GO:0001886)2.90519007
69regulation of membrane protein ectodomain proteolysis (GO:0051043)2.88563351
70receptor catabolic process (GO:0032801)2.88470107
71epithelial cell differentiation involved in prostate gland development (GO:0060742)2.88178136
72response to fluid shear stress (GO:0034405)2.86925759
73type B pancreatic cell proliferation (GO:0044342)2.86213738
74negative regulation of chondrocyte differentiation (GO:0032331)2.85673263
75hyaluronan catabolic process (GO:0030214)2.84886425
76vascular endothelial growth factor signaling pathway (GO:0038084)2.84285537
77Golgi transport vesicle coating (GO:0048200)2.83489825
78COPI coating of Golgi vesicle (GO:0048205)2.83489825
79multicellular organismal metabolic process (GO:0044236)2.80131683
80adherens junction assembly (GO:0034333)2.79463993
81regulation of SMAD protein import into nucleus (GO:0060390)2.79139085
82ganglion development (GO:0061548)2.77197829
83apoptotic process involved in morphogenesis (GO:0060561)2.76537448
84positive regulation of histone deacetylation (GO:0031065)2.75932994
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.75163150
86positive regulation of axon extension (GO:0045773)2.74308293
87cellular response to interferon-alpha (GO:0035457)2.74051454
88hemidesmosome assembly (GO:0031581)2.73121378
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71620327
90glial cell migration (GO:0008347)2.71560379
91endoplasmic reticulum unfolded protein response (GO:0030968)2.70253864
92heterochromatin organization (GO:0070828)2.68694996
93cell-cell junction maintenance (GO:0045217)2.67162980
94regulation of hippo signaling (GO:0035330)2.66210957
95L-serine transport (GO:0015825)2.64881708
96endothelial cell chemotaxis (GO:0035767)2.64394303
97Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64201287
98macrophage activation involved in immune response (GO:0002281)2.64153348
99platelet aggregation (GO:0070527)2.63307162
100vesicle coating (GO:0006901)2.62646596
101convergent extension (GO:0060026)2.62055334
102regulation of macrophage cytokine production (GO:0010935)2.61996481
103glycosphingolipid catabolic process (GO:0046479)2.61633452
104regulation of nuclease activity (GO:0032069)2.61483153
105positive regulation of SMAD protein import into nucleus (GO:0060391)2.60846369
106cell migration involved in sprouting angiogenesis (GO:0002042)2.59990963
107polarized epithelial cell differentiation (GO:0030859)2.59243040
108substrate adhesion-dependent cell spreading (GO:0034446)2.58979215
109maternal placenta development (GO:0001893)2.57057569
110neuron projection extension (GO:1990138)2.56742199
111cellular response to unfolded protein (GO:0034620)2.56604310
112regulation of tight junction assembly (GO:2000810)2.55042140
113extracellular fibril organization (GO:0043206)2.54650980
114negative regulation of smooth muscle cell migration (GO:0014912)2.54128497
115negative regulation of adherens junction organization (GO:1903392)2.50790948
116negative regulation of focal adhesion assembly (GO:0051895)2.50790948
117negative regulation of cell junction assembly (GO:1901889)2.50790948
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49980512
119cellular response to vitamin (GO:0071295)2.49472531
120regulation of establishment of planar polarity (GO:0090175)2.49209020
121pinocytosis (GO:0006907)2.47098980
122pentose-phosphate shunt (GO:0006098)2.46820572
123peptidyl-proline hydroxylation (GO:0019511)2.46605497
124germ cell migration (GO:0008354)2.46349530
125wound healing, spreading of cells (GO:0044319)2.45950610
126serine transport (GO:0032329)2.45669212
127ER-nucleus signaling pathway (GO:0006984)2.44929282
128cellular copper ion homeostasis (GO:0006878)2.44736092
129regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.43849533
130regulation of p38MAPK cascade (GO:1900744)2.43641546
131positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43526752
132mating behavior (GO:0007617)2.43521231
1334-hydroxyproline metabolic process (GO:0019471)2.42789060
134oligosaccharide catabolic process (GO:0009313)2.42676779
135heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.42300216
136regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41122332
137substrate-dependent cell migration (GO:0006929)2.40743916
138blood vessel endothelial cell migration (GO:0043534)2.40506143
139positive regulation of bone resorption (GO:0045780)2.40279297
140positive regulation of bone remodeling (GO:0046852)2.40279297
141positive regulation of receptor recycling (GO:0001921)2.40011366
142cochlea morphogenesis (GO:0090103)2.39007151
143cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.38537691
144regulation of mononuclear cell migration (GO:0071675)2.38184631
145regulation of extracellular matrix disassembly (GO:0010715)2.37568759
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37456955
147fibroblast migration (GO:0010761)2.36853164
148cortical cytoskeleton organization (GO:0030865)2.36851534
149cell migration involved in heart development (GO:0060973)2.35149312
150embryo implantation (GO:0007566)2.32168971
151glycolipid catabolic process (GO:0019377)2.31714306
152positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.31180215
153NADPH regeneration (GO:0006740)2.31060493
154craniofacial suture morphogenesis (GO:0097094)2.29775897
155negative regulation of microtubule polymerization (GO:0031115)2.28846431
156endocytic recycling (GO:0032456)2.28330837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.45705056
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.74054252
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.40188383
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.15358725
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.82196589
6* ELK3_25401928_ChIP-Seq_HUVEC_Human2.49763602
7CLOCK_20551151_ChIP-Seq_293T_Human2.41030653
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.27587412
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24934844
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18425294
11LXR_22292898_ChIP-Seq_THP-1_Human1.97431994
12KDM2B_26808549_Chip-Seq_DND41_Human1.96801004
13* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.94808426
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92374173
15RACK7_27058665_Chip-Seq_MCF-7_Human1.90344611
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85268355
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84957831
18VDR_21846776_ChIP-Seq_THP-1_Human1.84452277
19ATF3_27146783_Chip-Seq_COLON_Human1.83727185
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82025980
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80911281
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79389074
23MYC_22102868_ChIP-Seq_BL_Human1.75892902
24* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74568174
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72877122
26TCF7_22412390_ChIP-Seq_EML_Mouse1.72743731
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.71504147
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70381785
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66355569
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66062926
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65645490
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63576131
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63560885
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.62599426
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61169064
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.60604118
37ZNF263_19887448_ChIP-Seq_K562_Human1.59459692
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58112615
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57887453
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57690378
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57251578
42* ERG_21242973_ChIP-ChIP_JURKAT_Human1.55370381
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52985190
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52566216
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52201454
46KDM2B_26808549_Chip-Seq_K562_Human1.51130859
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51053984
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50708435
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.49332855
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48887442
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48296141
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45262703
53TFEB_21752829_ChIP-Seq_HELA_Human1.44960621
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41173020
55TP53_22127205_ChIP-Seq_IMR90_Human1.40880608
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39755045
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38748764
58* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37640834
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.36221721
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36199968
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.34925171
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.33353695
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32118374
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31977188
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31962675
66* TET1_21490601_ChIP-Seq_MESCs_Mouse1.31736952
67FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.31280591
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31039639
69* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30182463
70* KDM2B_26808549_Chip-Seq_JURKAT_Human1.30003425
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29916759
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29864772
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27716042
74SPI1_23127762_ChIP-Seq_K562_Human1.27571288
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27519964
76* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27453014
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27210971
78VDR_24763502_ChIP-Seq_THP-1_Human1.27050089
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26868566
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26600365
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26402758
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26275085
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26275085
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26082563
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25986500
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.25317577
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.24822656
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22917058
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22847890
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21623008
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.20452959
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.19564408
93MAF_26560356_Chip-Seq_TH1_Human1.18466516
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17290704
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17268942
96* NCOR1_26117541_ChIP-Seq_K562_Human1.17001410
97* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16875127
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15993851
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15931994
100* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14842651
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14784983
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14556150
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12376867
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11106754
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11021654
106GATA1_19941826_ChIP-Seq_K562_Human1.10352227
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10189590
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09714747
109OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08774451
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08718218
111* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08698739
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07778406
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06397552
114* UTX_26944678_Chip-Seq_JUKART_Human1.06310597
115CREB1_26743006_Chip-Seq_LNCaP_Human1.06093648
116BRD4_25478319_ChIP-Seq_HGPS_Human1.05903195
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05666376
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.05565867
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04756088
120* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04249118
121CTCF_27219007_Chip-Seq_Bcells_Human1.03101302
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.02988275
123CJUN_26792858_Chip-Seq_BT549_Human1.02596936
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02596202
125P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02232650
126CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02074629
127SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00401131
128* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99814752
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.99635376
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99252866
131* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99110378
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98594923
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98441036
134* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97728782
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96708065
136RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96646272
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96646272
138SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95913512
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.95885646
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.95885646
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92806840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.69950214
2MP0003705_abnormal_hypodermis_morpholog4.89991850
3MP0005058_abnormal_lysosome_morphology3.52913036
4MP0005171_absent_coat_pigmentation3.36884814
5MP0005257_abnormal_intraocular_pressure3.29420639
6MP0005275_abnormal_skin_tensile3.25306330
7MP0003566_abnormal_cell_adhesion3.12634923
8MP0003172_abnormal_lysosome_physiology2.66906467
9MP0001958_emphysema2.66829066
10MP0003303_peritoneal_inflammation2.64918709
11MP0010352_gastrointestinal_tract_polyps2.38782835
12MP0005623_abnormal_meninges_morphology2.37640836
13MP0003300_gastrointestinal_ulcer2.31245671
14MP0003279_aneurysm2.29210269
15MP0002877_abnormal_melanocyte_morpholog2.26806717
16MP0004272_abnormal_basement_membrane2.16781206
17MP0005076_abnormal_cell_differentiation2.12776567
18MP0003091_abnormal_cell_migration2.10888762
19MP0004858_abnormal_nervous_system2.07221734
20MP0005409_darkened_coat_color2.01389670
21MP0009840_abnormal_foam_cell1.99586108
22MP0005023_abnormal_wound_healing1.95553100
23MP0003329_amyloid_beta_deposits1.92519373
24MP0005503_abnormal_tendon_morphology1.90324884
25MP0000733_abnormal_muscle_development1.79631195
26MP0006054_spinal_hemorrhage1.78530417
27MP0003136_yellow_coat_color1.77307110
28MP0010307_abnormal_tumor_latency1.76437606
29MP0005408_hypopigmentation1.66260377
30MP0000569_abnormal_digit_pigmentation1.62061441
31MP0001849_ear_inflammation1.61993062
32MP0009278_abnormal_bone_marrow1.60985617
33MP0003448_altered_tumor_morphology1.49807469
34MP0003283_abnormal_digestive_organ1.37437930
35MP0000372_irregular_coat_pigmentation1.36121859
36MP0002060_abnormal_skin_morphology1.33867695
37MP0003045_fibrosis1.33083149
38MP0006082_CNS_inflammation1.32850367
39MP0003191_abnormal_cellular_cholesterol1.32370063
40MP0000015_abnormal_ear_pigmentation1.30503923
41MP0010234_abnormal_vibrissa_follicle1.28941372
42MP0000858_altered_metastatic_potential1.25754992
43MP0003950_abnormal_plasma_membrane1.22873641
44MP0003436_decreased_susceptibility_to1.22407309
45MP0004185_abnormal_adipocyte_glucose1.20119964
46MP0008260_abnormal_autophagy1.19861581
47MP0004947_skin_inflammation1.19108941
48MP0003634_abnormal_glial_cell1.19007668
49MP0002998_abnormal_bone_remodeling1.18912617
50MP0001533_abnormal_skeleton_physiology1.18713344
51MP0000604_amyloidosis1.16387484
52MP0003122_maternal_imprinting1.16180669
53MP0005508_abnormal_skeleton_morphology1.16132622
54MP0004510_myositis1.15252273
55MP0001348_abnormal_lacrimal_gland1.15231396
56MP0001542_abnormal_bone_strength1.13851606
57MP0003942_abnormal_urinary_system1.13517492
58MP0000767_abnormal_smooth_muscle1.12970169
59MP0002896_abnormal_bone_mineralization1.11286639
60MP0000750_abnormal_muscle_regeneration1.10730222
61MP0001879_abnormal_lymphatic_vessel1.09635839
62MP0002075_abnormal_coat/hair_pigmentati1.05767050
63MP0003453_abnormal_keratinocyte_physiol1.04743351
64MP0000537_abnormal_urethra_morphology1.03861802
65MP0005451_abnormal_body_composition1.01607245
66MP0001915_intracranial_hemorrhage1.01184194
67MP0005197_abnormal_uvea_morphology0.99772720
68MP0001186_pigmentation_phenotype0.98468743
69MP0002089_abnormal_postnatal_growth/wei0.97710540
70MP0005390_skeleton_phenotype0.97220995
71MP0005595_abnormal_vascular_smooth0.95334147
72MP0003123_paternal_imprinting0.93260262
73MP0005464_abnormal_platelet_physiology0.90925367
74MP0000343_altered_response_to0.90843027
75MP0001243_abnormal_dermal_layer0.90252860
76MP0003941_abnormal_skin_development0.88935650
77MP0000003_abnormal_adipose_tissue0.88111408
78MP0002295_abnormal_pulmonary_circulatio0.87365936
79MP0002168_other_aberrant_phenotype0.85381446
80MP0000371_diluted_coat_color0.85096633
81MP0000428_abnormal_craniofacial_morphol0.84588684
82MP0000778_abnormal_nervous_system0.84480367
83MP0002697_abnormal_eye_size0.83082070
84MP0008961_abnormal_basal_metabolism0.82519591
85MP0002092_abnormal_eye_morphology0.82483051
86MP0010030_abnormal_orbit_morphology0.82172509
87MP0005164_abnormal_response_to0.81426951
88MP0001299_abnormal_eye_distance/0.79992498
89MP0004130_abnormal_muscle_cell0.79828522
90MP0005167_abnormal_blood-brain_barrier0.79642626
91MP0000462_abnormal_digestive_system0.78201953
92MP0001614_abnormal_blood_vessel0.77938972
93MP0005375_adipose_tissue_phenotype0.77230972
94MP0002933_joint_inflammation0.76912444
95MP0005397_hematopoietic_system_phenotyp0.76740985
96MP0001545_abnormal_hematopoietic_system0.76740985
97MP0000534_abnormal_ureter_morphology0.76189574
98MP0003795_abnormal_bone_structure0.75782000
99MP0009384_cardiac_valve_regurgitation0.75176748
100MP0002938_white_spotting0.73859689
101MP0005083_abnormal_biliary_tract0.73630726
102MP0000013_abnormal_adipose_tissue0.73564829
103MP0003385_abnormal_body_wall0.72538036
104MP0000751_myopathy0.72492063
105MP0002419_abnormal_innate_immunity0.71439657
106MP0005193_abnormal_anterior_eye0.71009657
107MP0002925_abnormal_cardiovascular_devel0.70038637
108MP0004197_abnormal_fetal_growth/weight/0.69856710
109MP0002090_abnormal_vision0.69075073
110MP0010368_abnormal_lymphatic_system0.67831287
111MP0000747_muscle_weakness0.67654435
112MP0009250_abnormal_appendicular_skeleto0.67120712
113MP0002128_abnormal_blood_circulation0.66718884
114MP0004087_abnormal_muscle_fiber0.66375410
115MP0003075_altered_response_to0.65688360
116MP0002254_reproductive_system_inflammat0.65436604
117MP0005621_abnormal_cell_physiology0.64959053
118MP0001324_abnormal_eye_pigmentation0.64198439
119MP0000432_abnormal_head_morphology0.62753862
120MP0008770_decreased_survivor_rate0.62670570
121MP0004233_abnormal_muscle_weight0.62219760
122MP0002113_abnormal_skeleton_development0.62142836
123MP0006138_congestive_heart_failure0.62007252
124MP0000249_abnormal_blood_vessel0.61997923
125MP0002177_abnormal_outer_ear0.61649634
126MP0004883_abnormal_blood_vessel0.61207655
127MP0002796_impaired_skin_barrier0.60576737
128MP0003115_abnormal_respiratory_system0.60373498
129MP0001175_abnormal_lung_morphology0.60250008
130MP0009053_abnormal_anal_canal0.60072778
131MP0000049_abnormal_middle_ear0.60031479
132MP0003690_abnormal_glial_cell0.59695866
133MP0003935_abnormal_craniofacial_develop0.59676782
134MP0002116_abnormal_craniofacial_bone0.58599721
135MP0000163_abnormal_cartilage_morphology0.58406086
136MP0000759_abnormal_skeletal_muscle0.57206828
137MP0000762_abnormal_tongue_morphology0.55214329
138MP0009672_abnormal_birth_weight0.54060112
139MP0004859_abnormal_synaptic_plasticity0.52402283
140MP0000467_abnormal_esophagus_morphology0.50028700
141MP0005248_abnormal_Harderian_gland0.49902846

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.28076113
2Protrusio acetabuli (HP:0003179)5.21227938
3Cerebral aneurysm (HP:0004944)4.35707103
4Increased cerebral lipofuscin (HP:0011813)4.32868564
5Ankle contracture (HP:0006466)3.77874822
6Cervical subluxation (HP:0003308)3.65332086
7Shallow orbits (HP:0000586)3.53957136
8Dysostosis multiplex (HP:0000943)3.25895763
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.19519696
10Peritonitis (HP:0002586)3.17761319
11Urinary glycosaminoglycan excretion (HP:0003541)3.12239295
12Mucopolysacchariduria (HP:0008155)3.12239295
13Distal upper limb amyotrophy (HP:0007149)3.10167201
14Upper limb amyotrophy (HP:0009129)3.10167201
15Neurofibrillary tangles (HP:0002185)2.99503952
16Aortic dissection (HP:0002647)2.97197832
17Vertebral compression fractures (HP:0002953)2.92797695
18Abnormality of polysaccharide metabolism (HP:0011012)2.92274574
19Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92274574
20Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92274574
21Atrophic scars (HP:0001075)2.90387534
22Hand muscle atrophy (HP:0009130)2.86917278
23Bladder diverticulum (HP:0000015)2.81313937
24Dilatation of the ascending aorta (HP:0005111)2.79339578
25Increased connective tissue (HP:0009025)2.78019997
26Genu recurvatum (HP:0002816)2.74702620
27Fragile skin (HP:0001030)2.70115240
28Aortic aneurysm (HP:0004942)2.69490166
29Mitral valve prolapse (HP:0001634)2.66642927
30Nuclear cataract (HP:0100018)2.64403904
31Vacuolated lymphocytes (HP:0001922)2.54913539
32Abnormality of liposaccharide metabolism (HP:0010968)2.49951222
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.49951222
34Abnormality of glycolipid metabolism (HP:0010969)2.49951222
35Broad metatarsal (HP:0001783)2.48926038
36Insomnia (HP:0100785)2.43220373
37Ulnar bowing (HP:0003031)2.41099196
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.38300672
39Osteolytic defects of the hand bones (HP:0009699)2.38300672
40Wrist flexion contracture (HP:0001239)2.37401057
41Aneurysm (HP:0002617)2.35689651
42Soft skin (HP:0000977)2.33212848
43Spinal rigidity (HP:0003306)2.32043074
44Cortical dysplasia (HP:0002539)2.31603444
45Blue sclerae (HP:0000592)2.29930042
46Increased density of long bones (HP:0006392)2.29190009
47Axonal loss (HP:0003447)2.28365055
48Hypoventilation (HP:0002791)2.27998604
49Asymmetric septal hypertrophy (HP:0001670)2.26230402
50Wormian bones (HP:0002645)2.25901849
51Loss of speech (HP:0002371)2.25182715
52Achilles tendon contracture (HP:0001771)2.24231028
53White forelock (HP:0002211)2.22150307
54Myocardial infarction (HP:0001658)2.18514328
55Thin bony cortex (HP:0002753)2.13788567
56Long toe (HP:0010511)2.13523275
57Striae distensae (HP:0001065)2.13279494
58Biconcave vertebral bodies (HP:0004586)2.11924962
59Difficulty climbing stairs (HP:0003551)2.11296970
60Mitral regurgitation (HP:0001653)2.10248448
61Abnormality of the acetabulum (HP:0003170)2.08667451
62Tetraparesis (HP:0002273)2.08338005
63Bowel diverticulosis (HP:0005222)2.08325113
64Turricephaly (HP:0000262)2.04987512
65Hyperacusis (HP:0010780)2.04658175
66Disinhibition (HP:0000734)2.04145764
67Neonatal short-limb short stature (HP:0008921)2.02950062
68Subacute progressive viral hepatitis (HP:0006572)2.02271703
69Natal tooth (HP:0000695)2.00993155
70Type 1 muscle fiber predominance (HP:0003803)2.00535369
71Abnormality of the Achilles tendon (HP:0005109)1.99803552
72Nonimmune hydrops fetalis (HP:0001790)1.99081953
73Enlarged penis (HP:0000040)1.98503414
74Cholecystitis (HP:0001082)1.97339528
75Abnormal gallbladder physiology (HP:0012438)1.97339528
76Back pain (HP:0003418)1.96251436
77Hyperextensible skin (HP:0000974)1.92749147
78Global brain atrophy (HP:0002283)1.92712633
79Renal duplication (HP:0000075)1.91147953
80Slender build (HP:0001533)1.90529080
81Vascular tortuosity (HP:0004948)1.89509299
82Hammertoe (HP:0001765)1.88347145
83Mildly elevated creatine phosphokinase (HP:0008180)1.88140066
84Upper limb muscle weakness (HP:0003484)1.87981183
85Lower limb amyotrophy (HP:0007210)1.85990951
86Frequent falls (HP:0002359)1.85370706
87Radial bowing (HP:0002986)1.84681241
88J-shaped sella turcica (HP:0002680)1.83585357
89Bowed forearm bones (HP:0003956)1.83287603
90Bowing of the arm (HP:0006488)1.83287603
91Hypoplasia of the iris (HP:0007676)1.83247130
92Ovoid vertebral bodies (HP:0003300)1.83129127
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83007924
94Spondylolisthesis (HP:0003302)1.82665885
95Abnormality of dentin (HP:0010299)1.82155276
96Deviation of the hallux (HP:0010051)1.82041323
97Hypercortisolism (HP:0001578)1.82018246
98Elbow flexion contracture (HP:0002987)1.81927515
99Camptodactyly of toe (HP:0001836)1.81915637
100Increased variability in muscle fiber diameter (HP:0003557)1.81451452
101Joint stiffness (HP:0001387)1.80723313
102Scapular winging (HP:0003691)1.80240789
103Hallux valgus (HP:0001822)1.79789113
104Patchy hypopigmentation of hair (HP:0011365)1.79081790
105Distal lower limb amyotrophy (HP:0008944)1.78931672
106Disproportionate tall stature (HP:0001519)1.78207659
107Increased CSF protein (HP:0002922)1.76911775
108Mitral stenosis (HP:0001718)1.75591378
109Diminished motivation (HP:0000745)1.74661765
110Generalized amyotrophy (HP:0003700)1.73352742
111Follicular hyperkeratosis (HP:0007502)1.70947279
112Apathy (HP:0000741)1.70551668
113Supranuclear gaze palsy (HP:0000605)1.70081710
114Arterial tortuosity (HP:0005116)1.69619295
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69062051
116Short nail (HP:0001799)1.67214749
117Abnormality of the peritoneum (HP:0002585)1.66372770
118Osteopenia (HP:0000938)1.65784262
119Abnormality of skeletal muscle fiber size (HP:0012084)1.65370678
120Increased mean platelet volume (HP:0011877)1.65283757
121Abnormal delivery (HP:0001787)1.65201033
122Skin nodule (HP:0200036)1.64565174
123Hematochezia (HP:0002573)1.64512547
124Cerebral inclusion bodies (HP:0100314)1.64139535
125Long palpebral fissure (HP:0000637)1.63814750
126Arnold-Chiari malformation (HP:0002308)1.63676768
127Joint laxity (HP:0001388)1.63439152
128Breech presentation (HP:0001623)1.62590555
129Distal lower limb muscle weakness (HP:0009053)1.62326001
130Delayed cranial suture closure (HP:0000270)1.61998582
131Wide anterior fontanel (HP:0000260)1.61659968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.34500793
2PKN24.04542807
3ERN13.46282000
4TTN3.10538742
5EEF2K2.65912187
6BMX2.56504139
7DDR22.54178364
8RIPK12.44753208
9PDGFRA2.42129894
10TIE12.19723633
11PTK62.11903521
12SCYL22.11650625
13IRAK31.88667770
14MARK11.82912044
15LRRK21.80535269
16LATS21.75642258
17PAK41.68241794
18MAP3K101.59235447
19PTK21.56197737
20CDK121.54228348
21SIK11.51908949
22PAK21.47596484
23TBK11.41921299
24MAP3K61.39404130
25CAMK1D1.38847113
26MST1R1.38268727
27ERBB41.35912476
28ICK1.31153144
29EPHB11.29470322
30KSR21.26382953
31ARAF1.24493957
32SMG11.20864660
33TESK11.18124444
34NTRK11.17358060
35TGFBR21.16284001
36MET1.15695575
37PIM21.11601282
38LATS11.11498296
39MTOR1.11292384
40RET1.11025085
41KIT1.07521772
42ALK1.05791633
43KDR1.03770508
44EPHB21.02088101
45CAMKK11.00565089
46PDGFRB0.97912949
47PRKD20.97865327
48EPHA20.96247861
49MYLK0.94890303
50TAOK20.93930886
51CDK60.92457416
52CAMK1G0.91800249
53PAK60.91724387
54CDC42BPA0.90527181
55PRPF4B0.89683197
56TAOK10.89663045
57MAP2K30.89497634
58FER0.89462575
59ILK0.86728789
60CDK150.86209579
61MARK20.85551038
62MAP3K20.85535575
63CDK11A0.85158464
64CDK180.84116941
65CDK140.84076356
66TRPM70.83596670
67RPS6KA40.82663889
68ROCK20.81845521
69MATK0.80079315
70MAP3K90.78027694
71MOS0.75639839
72DMPK0.75485091
73STK30.74392326
74PRKG20.74274301
75DYRK1B0.74016352
76CSNK1G30.73114796
77MAP3K30.72655851
78STK100.72546076
79MAPKAPK30.71984608
80LIMK10.70719010
81MAP2K10.70608766
82MAP3K110.70155630
83RPS6KA20.68565278
84CSNK1G20.68249549
85ABL20.66834332
86DYRK20.65200498
87PRKD30.64041238
88MAP3K80.63919143
89CSNK1A1L0.63091207
90NEK10.62981280
91TESK20.62953286
92DAPK30.62238860
93FLT30.60997044
94TYRO30.58585226
95DYRK30.57880754
96NEK90.57369888
97PRKCH0.56657534
98BRAF0.56143145
99FGR0.55687179
100NME20.55653058
101HCK0.55533749
102BLK0.55214837
103MAP2K70.55027620
104CSK0.54144938
105STK380.53826628
106CDK70.53613037
107MAP2K20.53073020
108PAK10.52932747
109EGFR0.52427034
110PTK2B0.52281950
111JAK10.52175896
112FGFR40.51281142
113MAP3K10.50753431
114AKT20.49084516
115EPHA30.48722710
116FGFR10.48623306
117SRC0.47974113
118TYK20.47313155
119LMTK20.46901668
120ZAP700.45767824
121PAK30.45586083
122TAOK30.44415855
123ROCK10.43389922
124GSK3A0.42898947
125KSR10.42728770
126JAK20.42340011
127PRKD10.41399327
128CLK10.40323387
129SIK20.38790027
130CSNK1G10.37750505
131NEK20.36463814
132RPS6KC10.35576288
133RPS6KL10.35576288
134CDK90.34910511
135AURKA0.34797997
136BCR0.33020349
137CAMK2G0.30358107

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.05453852
2Lysosome_Homo sapiens_hsa041422.85462798
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.20038139
4ECM-receptor interaction_Homo sapiens_hsa045122.02695285
5Focal adhesion_Homo sapiens_hsa045101.91953532
6Chronic myeloid leukemia_Homo sapiens_hsa052201.88672728
7Amoebiasis_Homo sapiens_hsa051461.80767659
8Proteoglycans in cancer_Homo sapiens_hsa052051.78863450
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72864729
10Bladder cancer_Homo sapiens_hsa052191.67026762
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64038939
12Pentose phosphate pathway_Homo sapiens_hsa000301.60451913
13Phagosome_Homo sapiens_hsa041451.57343208
14Other glycan degradation_Homo sapiens_hsa005111.52906072
15Biosynthesis of amino acids_Homo sapiens_hsa012301.43919186
16Steroid biosynthesis_Homo sapiens_hsa001001.41120135
17Leishmaniasis_Homo sapiens_hsa051401.41030480
18Fructose and mannose metabolism_Homo sapiens_hsa000511.40210580
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38840024
20Adherens junction_Homo sapiens_hsa045201.37634196
21Osteoclast differentiation_Homo sapiens_hsa043801.37546818
22Axon guidance_Homo sapiens_hsa043601.36418821
23Tuberculosis_Homo sapiens_hsa051521.34711884
24Small cell lung cancer_Homo sapiens_hsa052221.33735693
25mTOR signaling pathway_Homo sapiens_hsa041501.31795604
26Shigellosis_Homo sapiens_hsa051311.30574826
27Apoptosis_Homo sapiens_hsa042101.30535579
28Malaria_Homo sapiens_hsa051441.30063206
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.29185092
30Synaptic vesicle cycle_Homo sapiens_hsa047211.25302496
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.24424263
32Pancreatic cancer_Homo sapiens_hsa052121.23445824
33Toxoplasmosis_Homo sapiens_hsa051451.23422524
34Salmonella infection_Homo sapiens_hsa051321.20669615
35Glioma_Homo sapiens_hsa052141.18445833
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17962603
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.15553999
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15338980
39VEGF signaling pathway_Homo sapiens_hsa043701.13713900
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11906867
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11190427
42MicroRNAs in cancer_Homo sapiens_hsa052061.11031891
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08241690
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07463780
45Endocytosis_Homo sapiens_hsa041441.06105921
46Carbon metabolism_Homo sapiens_hsa012001.06042181
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05790070
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04843212
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04353874
50Acute myeloid leukemia_Homo sapiens_hsa052211.04159879
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04104088
52Renal cell carcinoma_Homo sapiens_hsa052111.04063604
53Pertussis_Homo sapiens_hsa051331.01755180
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01520939
55Endometrial cancer_Homo sapiens_hsa052131.00548623
56Melanogenesis_Homo sapiens_hsa049161.00234440
57Platelet activation_Homo sapiens_hsa046110.98990441
58N-Glycan biosynthesis_Homo sapiens_hsa005100.97817494
59Sphingolipid metabolism_Homo sapiens_hsa006000.97731035
60Basal cell carcinoma_Homo sapiens_hsa052170.97061067
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96866765
62Viral myocarditis_Homo sapiens_hsa054160.96345521
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95927906
64Renin-angiotensin system_Homo sapiens_hsa046140.95641240
65Protein digestion and absorption_Homo sapiens_hsa049740.94889191
66HIF-1 signaling pathway_Homo sapiens_hsa040660.91553147
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91341143
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90796556
69Colorectal cancer_Homo sapiens_hsa052100.90490692
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90326883
71TNF signaling pathway_Homo sapiens_hsa046680.90286287
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.87001171
73Melanoma_Homo sapiens_hsa052180.86028324
74Notch signaling pathway_Homo sapiens_hsa043300.85969642
75Non-small cell lung cancer_Homo sapiens_hsa052230.84240310
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84062993
77Staphylococcus aureus infection_Homo sapiens_hsa051500.82540888
78Hippo signaling pathway_Homo sapiens_hsa043900.82185980
79Insulin resistance_Homo sapiens_hsa049310.81882830
80Estrogen signaling pathway_Homo sapiens_hsa049150.80297430
81Antigen processing and presentation_Homo sapiens_hsa046120.79116363
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79099081
83Galactose metabolism_Homo sapiens_hsa000520.78933894
84Prolactin signaling pathway_Homo sapiens_hsa049170.77445372
85Hepatitis B_Homo sapiens_hsa051610.77375995
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76982905
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75129076
88Dilated cardiomyopathy_Homo sapiens_hsa054140.74800098
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73810316
90Vitamin B6 metabolism_Homo sapiens_hsa007500.73664048
91Legionellosis_Homo sapiens_hsa051340.73310307
92Fatty acid elongation_Homo sapiens_hsa000620.73211212
93Viral carcinogenesis_Homo sapiens_hsa052030.72901546
94Insulin signaling pathway_Homo sapiens_hsa049100.72025001
95Collecting duct acid secretion_Homo sapiens_hsa049660.71165114
96B cell receptor signaling pathway_Homo sapiens_hsa046620.71117282
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69594375
98Dorso-ventral axis formation_Homo sapiens_hsa043200.69448928
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68609021
100Complement and coagulation cascades_Homo sapiens_hsa046100.67896822
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.67585837
102ErbB signaling pathway_Homo sapiens_hsa040120.67573893
103Thyroid cancer_Homo sapiens_hsa052160.67546301
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.67495332
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66486419
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65849080
107Caffeine metabolism_Homo sapiens_hsa002320.65723493
108Prion diseases_Homo sapiens_hsa050200.65631595
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65194288
110Rap1 signaling pathway_Homo sapiens_hsa040150.65145804
111Prostate cancer_Homo sapiens_hsa052150.64370841
112TGF-beta signaling pathway_Homo sapiens_hsa043500.63259609
113Vibrio cholerae infection_Homo sapiens_hsa051100.61922208
114Pathways in cancer_Homo sapiens_hsa052000.59792007
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59402265
116AMPK signaling pathway_Homo sapiens_hsa041520.59301194
117Rheumatoid arthritis_Homo sapiens_hsa053230.58917455
118Hedgehog signaling pathway_Homo sapiens_hsa043400.58418452
119p53 signaling pathway_Homo sapiens_hsa041150.57867757
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57643989
121Type II diabetes mellitus_Homo sapiens_hsa049300.57377496
122Tyrosine metabolism_Homo sapiens_hsa003500.55181531
123Tight junction_Homo sapiens_hsa045300.55006550
124HTLV-I infection_Homo sapiens_hsa051660.54114842
125Gap junction_Homo sapiens_hsa045400.52433729
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51969501
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51218432
128Wnt signaling pathway_Homo sapiens_hsa043100.50609702
129GnRH signaling pathway_Homo sapiens_hsa049120.48989799
130Ras signaling pathway_Homo sapiens_hsa040140.44146999
131Sulfur relay system_Homo sapiens_hsa041220.43879833
132Glutathione metabolism_Homo sapiens_hsa004800.41744447
133Lysine degradation_Homo sapiens_hsa003100.41288706

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