VAV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.08984834
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.80465486
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.80465486
4antigen processing and presentation of endogenous antigen (GO:0019883)5.44938693
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.26047973
6regulation of B cell receptor signaling pathway (GO:0050855)4.96952218
7positive regulation of B cell differentiation (GO:0045579)4.66060905
8regulation of gamma-delta T cell differentiation (GO:0045586)4.57044247
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.51381140
10negative regulation of cell killing (GO:0031342)4.51381140
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.43148362
12regulation of gamma-delta T cell activation (GO:0046643)4.34223482
13positive regulation by symbiont of host defense response (GO:0052509)4.21041670
14modulation by symbiont of host defense response (GO:0052031)4.21041670
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21041670
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21041670
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.21041670
18modulation by symbiont of host immune response (GO:0052553)4.21041670
19B cell receptor signaling pathway (GO:0050853)4.19901341
20regulation of B cell differentiation (GO:0045577)4.17202321
21regulation of interferon-beta biosynthetic process (GO:0045357)4.08421628
22detection of other organism (GO:0098543)4.08205706
23detection of bacterium (GO:0016045)3.90794148
24immunoglobulin mediated immune response (GO:0016064)3.88478367
25leukocyte aggregation (GO:0070486)3.88222050
26positive thymic T cell selection (GO:0045059)3.84426563
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.83964277
28microglial cell activation (GO:0001774)3.76205181
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.62785789
30antigen processing and presentation via MHC class Ib (GO:0002475)3.61985050
31negative regulation of phagocytosis (GO:0050765)3.58962681
32detection of external biotic stimulus (GO:0098581)3.56152123
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.56043639
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.54026935
35negative regulation of T cell mediated immunity (GO:0002710)3.53727309
36detection of molecule of bacterial origin (GO:0032490)3.53560505
37respiratory burst (GO:0045730)3.50862632
38neutrophil activation involved in immune response (GO:0002283)3.49381519
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.48822832
40negative T cell selection (GO:0043383)3.48220922
41regulation of mast cell degranulation (GO:0043304)3.48196574
42T-helper 1 type immune response (GO:0042088)3.48184895
43negative thymic T cell selection (GO:0045060)3.45990692
44macrophage activation (GO:0042116)3.44820142
45positive regulation of interferon-alpha production (GO:0032727)3.43752357
46mast cell activation (GO:0045576)3.43157496
47regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39830942
48positive regulation of mast cell activation (GO:0033005)3.34820650
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.33216064
50negative regulation of leukocyte mediated immunity (GO:0002704)3.32587547
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.29471443
52macrophage activation involved in immune response (GO:0002281)3.29150626
53regulation of interferon-alpha production (GO:0032647)3.28768264
54T cell migration (GO:0072678)3.28059276
55negative regulation of cytokine production involved in immune response (GO:0002719)3.24497295
56regulation of mast cell activation involved in immune response (GO:0033006)3.20794354
57defense response to protozoan (GO:0042832)3.19170315
58response to peptidoglycan (GO:0032494)3.17727622
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.17480687
60positive regulation of antigen processing and presentation (GO:0002579)3.17378368
61response to interleukin-15 (GO:0070672)3.17261968
62tolerance induction (GO:0002507)3.16519931
63B cell mediated immunity (GO:0019724)3.16196732
64T cell homeostasis (GO:0043029)3.15081404
65detection of biotic stimulus (GO:0009595)3.14761756
66regulation of mast cell activation (GO:0033003)3.13895251
67myeloid cell activation involved in immune response (GO:0002275)3.13312855
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11798123
69cellular extravasation (GO:0045123)3.10798616
70myeloid dendritic cell activation (GO:0001773)3.10754126
71regulation of T cell tolerance induction (GO:0002664)3.09955376
72interferon-gamma production (GO:0032609)3.08891461
73response to protozoan (GO:0001562)3.08593167
74response to muramyl dipeptide (GO:0032495)3.06346777
75mature B cell differentiation (GO:0002335)3.06183227
76positive T cell selection (GO:0043368)3.05960629
77regulation of leukocyte degranulation (GO:0043300)3.05384992
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.05030594
79positive regulation of mast cell degranulation (GO:0043306)3.05030594
80ribosomal small subunit assembly (GO:0000028)3.02724582
81response to type I interferon (GO:0034340)3.02114421
82regulation of tolerance induction (GO:0002643)3.01740372
83NIK/NF-kappaB signaling (GO:0038061)2.99330993
84type I interferon signaling pathway (GO:0060337)2.99286075
85cellular response to type I interferon (GO:0071357)2.99286075
86regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99031589
87lymphocyte homeostasis (GO:0002260)2.95807972
88regulation of alpha-beta T cell proliferation (GO:0046640)2.95775089
89interferon-gamma-mediated signaling pathway (GO:0060333)2.95719041
90thymic T cell selection (GO:0045061)2.95278600
91pinocytosis (GO:0006907)2.94604791
92antigen receptor-mediated signaling pathway (GO:0050851)2.94146955
93negative regulation of interleukin-12 production (GO:0032695)2.92077039
94neutrophil activation (GO:0042119)2.89940608
95B cell homeostasis (GO:0001782)2.89730757
96negative regulation of innate immune response (GO:0045824)2.88845573
97neutrophil mediated immunity (GO:0002446)2.87875414
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86999063
99regulation of natural killer cell mediated immunity (GO:0002715)2.86999063
100myeloid leukocyte activation (GO:0002274)2.86628343
101negative regulation of interleukin-6 production (GO:0032715)2.85644523
102T cell selection (GO:0045058)2.82158214
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82050664
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.81654292
105regulation of T cell mediated cytotoxicity (GO:0001914)2.80642587
106mast cell degranulation (GO:0043303)2.80442487
107mast cell activation involved in immune response (GO:0002279)2.80442487
108regulation of T cell receptor signaling pathway (GO:0050856)2.79492118
109leukocyte cell-cell adhesion (GO:0007159)2.78632633
110positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78176947
111response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77861238
112response to host immune response (GO:0052572)2.77861238
113cellular response to zinc ion (GO:0071294)2.76990590
114myeloid dendritic cell differentiation (GO:0043011)2.76772471
115regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75923504
116cellular response to interleukin-15 (GO:0071350)2.73945114
117germinal center formation (GO:0002467)2.73846587
118actin nucleation (GO:0045010)2.73289906
119mature B cell differentiation involved in immune response (GO:0002313)2.71321501
120granulocyte activation (GO:0036230)2.70036100
121response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.69239557
122response to host (GO:0075136)2.69239557
123response to host defenses (GO:0052200)2.69239557
124positive regulation of granulocyte differentiation (GO:0030854)2.68170827
125JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68099009
126leukocyte homeostasis (GO:0001776)2.67803799
127regulation of antigen processing and presentation (GO:0002577)2.67755775
128positive regulation of isotype switching (GO:0045830)2.67699419
129positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62822048
130negative regulation of granulocyte differentiation (GO:0030853)2.61796837
131negative regulation of erythrocyte differentiation (GO:0045647)2.61626307
132leukocyte degranulation (GO:0043299)2.61026325
133negative regulation of B cell proliferation (GO:0030889)2.60351457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20902355
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.46621301
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.85403579
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68111510
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.51833373
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49816430
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41589170
8MYC_22102868_ChIP-Seq_BL_Human3.07235945
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.97494384
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.88955280
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.80668437
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80365093
13* VDR_21846776_ChIP-Seq_THP-1_Human2.79761625
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77267169
15* SCL_19346495_ChIP-Seq_HPC-7_Human2.70804118
16* EGR1_19374776_ChIP-ChIP_THP-1_Human2.68505547
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61511150
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.58664269
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43638495
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42358000
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41033080
22* SPI1_23547873_ChIP-Seq_NB4_Human2.40902750
23MYB_26560356_Chip-Seq_TH2_Human2.38457384
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35588577
25MAF_26560356_Chip-Seq_TH1_Human2.26889070
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.19698996
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16806700
28* VDR_24763502_ChIP-Seq_THP-1_Human2.13519204
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.13169971
30MYB_26560356_Chip-Seq_TH1_Human2.12930066
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12599872
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.10275125
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04132042
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03085545
35UTX_26944678_Chip-Seq_JUKART_Human2.01952745
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01127733
37* RUNX_20019798_ChIP-Seq_JUKART_Human2.00215881
38VDR_24787735_ChIP-Seq_THP-1_Human1.96677935
39* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90244266
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89178946
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.81301487
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78509773
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76462762
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74320028
45* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70780205
46* SPI1_23127762_ChIP-Seq_K562_Human1.69833391
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68571223
48GATA1_22025678_ChIP-Seq_K562_Human1.64157957
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64004008
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.59168296
51CIITA_25753668_ChIP-Seq_RAJI_Human1.52950955
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51585194
53MAF_26560356_Chip-Seq_TH2_Human1.46986282
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44217023
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43117019
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42580450
57GATA3_27048872_Chip-Seq_THYMUS_Human1.42125235
58PU_27001747_Chip-Seq_BMDM_Mouse1.41855969
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41444105
60* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36064868
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35400551
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30363750
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28353161
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27577562
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27069990
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26756060
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26519763
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25938566
69GATA1_19941826_ChIP-Seq_K562_Human1.25849505
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.25818330
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25293928
72VDR_23849224_ChIP-Seq_CD4+_Human1.22794991
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22474180
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19021203
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18160579
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17913637
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17727677
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17181914
79KDM2B_26808549_Chip-Seq_DND41_Human1.16972308
80FOXP3_21729870_ChIP-Seq_TREG_Human1.13934633
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.13928956
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13922936
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13613774
84BCL6_27268052_Chip-Seq_Bcells_Human1.12770720
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11748488
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09755762
87TFEB_21752829_ChIP-Seq_HELA_Human1.07757531
88LXR_22292898_ChIP-Seq_THP-1_Human1.06916617
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.04788328
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.04684953
91GATA3_26560356_Chip-Seq_TH2_Human1.04177342
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03449870
93BCOR_27268052_Chip-Seq_Bcells_Human1.03120148
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03032286
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00639288
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00396524
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99793945
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99051610
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98440187
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98438929
101E2F1_21310950_ChIP-Seq_MCF-7_Human0.98012987
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97742211
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96223410
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93995628
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92124638
106EST1_17652178_ChIP-ChIP_JURKAT_Human0.90553137
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89927090
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.89908106
109GATA2_19941826_ChIP-Seq_K562_Human0.89690884
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.88639833
111* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85885607
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85024315
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83415576
114XRN2_22483619_ChIP-Seq_HELA_Human0.82981377
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82626371
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.81341511
117STAT1_20625510_ChIP-Seq_HELA_Human0.81282505
118NCOR1_26117541_ChIP-Seq_K562_Human0.79416502
119MYC_18358816_ChIP-ChIP_MESCs_Mouse0.78876396
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78573171
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.78445848
122ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78335144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.27362633
2MP0005671_abnormal_response_to3.28572581
3MP0000685_abnormal_immune_system3.11786333
4* MP0001800_abnormal_humoral_immune3.07932013
5MP0003436_decreased_susceptibility_to3.02782265
6MP0003303_peritoneal_inflammation2.97753817
7MP0009785_altered_susceptibility_to2.88429172
8MP0005000_abnormal_immune_tolerance2.87424789
9MP0001790_abnormal_immune_system2.86228558
10MP0005387_immune_system_phenotype2.86228558
11* MP0002452_abnormal_antigen_presenting2.80161281
12MP0002396_abnormal_hematopoietic_system2.79804116
13MP0003763_abnormal_thymus_physiology2.73160213
14* MP0002723_abnormal_immune_serum2.67860416
15* MP0002420_abnormal_adaptive_immunity2.64314291
16* MP0005025_abnormal_response_to2.62524772
17* MP0001819_abnormal_immune_cell2.62159012
18* MP0002419_abnormal_innate_immunity2.62034216
19* MP0002398_abnormal_bone_marrow2.47757916
20MP0005464_abnormal_platelet_physiology2.47539783
21MP0002148_abnormal_hypersensitivity_rea2.34939279
22MP0002166_altered_tumor_susceptibility2.28205196
23MP0006082_CNS_inflammation2.27247738
24* MP0000716_abnormal_immune_system2.23994588
25MP0002405_respiratory_system_inflammati2.19134259
26* MP0000689_abnormal_spleen_morphology2.15954125
27MP0009333_abnormal_splenocyte_physiolog2.07117536
28* MP0002722_abnormal_immune_system2.04644885
29MP0005058_abnormal_lysosome_morphology2.04218958
30MP0003172_abnormal_lysosome_physiology1.99865764
31MP0004808_abnormal_hematopoietic_stem1.97503775
32MP0001545_abnormal_hematopoietic_system1.93957687
33MP0005397_hematopoietic_system_phenotyp1.93957687
34* MP0002429_abnormal_blood_cell1.92635829
35MP0001873_stomach_inflammation1.92447863
36MP0010155_abnormal_intestine_physiology1.92045922
37MP0000465_gastrointestinal_hemorrhage1.85911133
38MP0009278_abnormal_bone_marrow1.85649051
39MP0003724_increased_susceptibility_to1.84347003
40MP0001853_heart_inflammation1.80122234
41MP0001845_abnormal_inflammatory_respons1.79868751
42MP0004947_skin_inflammation1.79604558
43MP0002006_tumorigenesis1.79232476
44MP0005174_abnormal_tail_pigmentation1.78912129
45* MP0000703_abnormal_thymus_morphology1.72049460
46MP0004510_myositis1.60427831
47MP0000490_abnormal_crypts_of1.51254163
48MP0001533_abnormal_skeleton_physiology1.49522198
49MP0003191_abnormal_cellular_cholesterol1.48582511
50MP0003866_abnormal_defecation1.47378369
51MP0005451_abnormal_body_composition1.46496702
52MP0003690_abnormal_glial_cell1.40601919
53MP0008469_abnormal_protein_level1.40103758
54MP0003183_abnormal_peptide_metabolism1.34442445
55MP0002933_joint_inflammation1.33334948
56MP0010307_abnormal_tumor_latency1.33186714
57MP0002254_reproductive_system_inflammat1.27123968
58MP0000858_altered_metastatic_potential1.26714202
59MP0005310_abnormal_salivary_gland1.23829703
60* MP0003300_gastrointestinal_ulcer1.21212967
61MP0008260_abnormal_autophagy1.21107246
62MP0005075_abnormal_melanosome_morpholog1.18570512
63MP0003448_altered_tumor_morphology1.18413768
64MP0000015_abnormal_ear_pigmentation1.17642806
65MP0000569_abnormal_digit_pigmentation1.17180303
66MP0010094_abnormal_chromosome_stability1.14676648
67MP0002277_abnormal_respiratory_mucosa1.13455033
68MP0004883_abnormal_blood_vessel1.13428657
69MP0008057_abnormal_DNA_replication1.12497647
70MP0009840_abnormal_foam_cell1.10974269
71MP0002019_abnormal_tumor_incidence1.08370744
72MP0001851_eye_inflammation1.08226005
73MP0003806_abnormal_nucleotide_metabolis1.06073729
74MP0003077_abnormal_cell_cycle1.02617655
75MP0000343_altered_response_to1.00877216
76MP0008004_abnormal_stomach_pH0.97754832
77MP0010352_gastrointestinal_tract_polyps0.96141853
78MP0005164_abnormal_response_to0.94265909
79MP0005167_abnormal_blood-brain_barrier0.93116589
80MP0002095_abnormal_skin_pigmentation0.92308285
81MP0008007_abnormal_cellular_replicative0.88850528
82MP0003656_abnormal_erythrocyte_physiolo0.88204659
83MP0002998_abnormal_bone_remodeling0.85250014
84MP0002138_abnormal_hepatobiliary_system0.83562397
85MP0003111_abnormal_nucleus_morphology0.82916187
86MP0004381_abnormal_hair_follicle0.82409438
87MP0009764_decreased_sensitivity_to0.82043403
88MP0009765_abnormal_xenobiotic_induced0.80886563
89MP0009763_increased_sensitivity_to0.77764078
90MP0003075_altered_response_to0.76955654
91MP0005076_abnormal_cell_differentiation0.76116119
92MP0000313_abnormal_cell_death0.74853467
93MP0002332_abnormal_exercise_endurance0.73644688
94MP0005166_decreased_susceptibility_to0.72422744
95MP0001663_abnormal_digestive_system0.70360338
96MP0002139_abnormal_hepatobiliary_system0.70085032
97MP0008058_abnormal_DNA_repair0.69926644
98MP0000371_diluted_coat_color0.68627405
99MP0002132_abnormal_respiratory_system0.67162729
100MP0000604_amyloidosis0.66961479
101MP0003453_abnormal_keratinocyte_physiol0.66743992
102MP0003566_abnormal_cell_adhesion0.66661480
103MP0003828_pulmonary_edema0.65086251
104MP0008874_decreased_physiological_sensi0.62475385
105MP0002693_abnormal_pancreas_physiology0.60787921
106* MP0003693_abnormal_embryo_hatching0.60387719
107MP0008873_increased_physiological_sensi0.59862968
108MP0000249_abnormal_blood_vessel0.59151536
109MP0000920_abnormal_myelination0.58374419
110MP0005390_skeleton_phenotype0.56781588
111MP0006054_spinal_hemorrhage0.56729742
112MP0003795_abnormal_bone_structure0.56672538
113MP0004957_abnormal_blastocyst_morpholog0.56639685
114MP0003329_amyloid_beta_deposits0.56266762
115MP0005381_digestive/alimentary_phenotyp0.54174962
116MP0002136_abnormal_kidney_physiology0.53679826
117MP0003221_abnormal_cardiomyocyte_apopto0.53226045
118MP0000598_abnormal_liver_morphology0.52649717
119MP0000609_abnormal_liver_physiology0.51243644
120MP0001986_abnormal_taste_sensitivity0.50866967
121MP0000350_abnormal_cell_proliferation0.50677191
122MP0002928_abnormal_bile_duct0.49690725

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.66836075
2Recurrent bacterial skin infections (HP:0005406)5.07944129
3Eczematoid dermatitis (HP:0000976)5.05807301
4Recurrent viral infections (HP:0004429)4.37626023
5Elevated erythrocyte sedimentation rate (HP:0003565)4.36997480
6Chronic otitis media (HP:0000389)4.35506444
7IgM deficiency (HP:0002850)4.26304036
8Recurrent fungal infections (HP:0002841)4.25908402
9Myositis (HP:0100614)4.12578205
10Recurrent bronchitis (HP:0002837)3.74691536
11Cellulitis (HP:0100658)3.73113335
12Thrombocytosis (HP:0001894)3.60097745
13Meningitis (HP:0001287)3.58995721
14Recurrent skin infections (HP:0001581)3.57594028
15Panhypogammaglobulinemia (HP:0003139)3.54434685
16Recurrent gram-negative bacterial infections (HP:0005420)3.53800218
17Mediastinal lymphadenopathy (HP:0100721)3.53415053
18T lymphocytopenia (HP:0005403)3.49932584
19Abnormality of macrophages (HP:0004311)3.45962413
20Chronic obstructive pulmonary disease (HP:0006510)3.45187773
21Obstructive lung disease (HP:0006536)3.45187773
22Keratoconjunctivitis sicca (HP:0001097)3.41768181
23Keratoconjunctivitis (HP:0001096)3.41744828
24Inflammation of the large intestine (HP:0002037)3.39882789
25Abnormality of T cell number (HP:0011839)3.36509487
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.35012838
27Gastrointestinal inflammation (HP:0004386)3.33512621
28Agammaglobulinemia (HP:0004432)3.26417107
29Gastrointestinal infarctions (HP:0005244)3.24729585
30Colitis (HP:0002583)3.23735156
31Recurrent cutaneous fungal infections (HP:0011370)3.23057476
32Chronic mucocutaneous candidiasis (HP:0002728)3.23057476
33Abnormality of T cells (HP:0002843)3.21961798
34Nasal polyposis (HP:0100582)3.16653526
35Stomatitis (HP:0010280)3.09668358
36Vasculitis (HP:0002633)3.08507083
37Thyroiditis (HP:0100646)3.08411706
38Increased IgM level (HP:0003496)3.00873343
39Autoimmune thrombocytopenia (HP:0001973)2.98458551
40B lymphocytopenia (HP:0010976)2.98326086
41Abnormality of B cell number (HP:0010975)2.98326086
42Petechiae (HP:0000967)2.97620382
43Vacuolated lymphocytes (HP:0001922)2.97016448
44Orchitis (HP:0100796)2.90975281
45Pustule (HP:0200039)2.88878876
46Abnormality of T cell physiology (HP:0011840)2.84597914
47Increased cerebral lipofuscin (HP:0011813)2.82869113
48Abnormality of the nasal mucosa (HP:0000433)2.82178463
49Lymphopenia (HP:0001888)2.81764937
50Prolonged bleeding time (HP:0003010)2.80746808
51Spontaneous hematomas (HP:0007420)2.78371518
52Optic neuritis (HP:0100653)2.78295739
53Retrobulbar optic neuritis (HP:0100654)2.78295739
54Leukocytosis (HP:0001974)2.78074294
55Eosinophilia (HP:0001880)2.77336525
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.75348234
57Osteomyelitis (HP:0002754)2.70879215
58Gingivitis (HP:0000230)2.65095736
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.60721863
60Gastrointestinal stroma tumor (HP:0100723)2.59919615
61IgG deficiency (HP:0004315)2.59858510
62Granulocytopenia (HP:0001913)2.57857229
63Abnormality of the fingertips (HP:0001211)2.57696383
64Periodontitis (HP:0000704)2.56737886
65Interstitial pulmonary disease (HP:0006530)2.55430473
66Severe combined immunodeficiency (HP:0004430)2.53939437
67Abnormality of eosinophils (HP:0001879)2.52759719
68Abnormal platelet function (HP:0011869)2.48348388
69Impaired platelet aggregation (HP:0003540)2.48348388
70Epistaxis (HP:0000421)2.47689549
71Combined immunodeficiency (HP:0005387)2.47390558
72Episodic fever (HP:0001954)2.41382235
73Autoimmune hemolytic anemia (HP:0001890)2.41357442
74Anorexia (HP:0002039)2.41132515
75Arterial thrombosis (HP:0004420)2.41003645
76Chronic diarrhea (HP:0002028)2.39277494
77Increased serum ferritin (HP:0003281)2.38934970
78Verrucae (HP:0200043)2.38537206
79Papilloma (HP:0012740)2.38537206
80Chronic sinusitis (HP:0011109)2.37398486
81Pulmonary embolism (HP:0002204)2.37085780
82Pulmonary infiltrates (HP:0002113)2.36537449
83Systemic lupus erythematosus (HP:0002725)2.35792833
84Hypergammaglobulinemia (HP:0010702)2.35649287
85Dysostosis multiplex (HP:0000943)2.34290411
86Recurrent sinusitis (HP:0011108)2.34064364
87Lymphoma (HP:0002665)2.33712982
88Increased IgE level (HP:0003212)2.33274714
89Gangrene (HP:0100758)2.32823680
90Encephalitis (HP:0002383)2.32493786
91Hematochezia (HP:0002573)2.30683949
92Abnormality of the prostate (HP:0008775)2.29098688
93Purpura (HP:0000979)2.27300736
94Hemoptysis (HP:0002105)2.25698170
95Agnosia (HP:0010524)2.25612688
96Abnormality of the pleura (HP:0002103)2.25371756
97Amyloidosis (HP:0011034)2.25084201
98Abnormality of glycolipid metabolism (HP:0010969)2.24531984
99Abnormality of liposaccharide metabolism (HP:0010968)2.24531984
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.24531984
101Chest pain (HP:0100749)2.24068111
102Recurrent pneumonia (HP:0006532)2.23552168
103Gingival bleeding (HP:0000225)2.22997507
104Mutism (HP:0002300)2.20315956
105IgA deficiency (HP:0002720)2.19911310
106Hypochromic anemia (HP:0001931)2.16681311
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16075338
108Emphysema (HP:0002097)2.15164178
109Polyneuropathy (HP:0001271)2.13422489
110Loss of speech (HP:0002371)2.13068114
111Urticaria (HP:0001025)2.10630271
112Abnormality of iron homeostasis (HP:0011031)2.10020228
113Recurrent lower respiratory tract infections (HP:0002783)2.09777373
114Skin ulcer (HP:0200042)2.08667598
115Sepsis (HP:0100806)2.08185125
116Abnormality of polysaccharide metabolism (HP:0011012)2.08172748
117Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08172748
118Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08172748
119Disinhibition (HP:0000734)2.07468398
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05727183
121Hepatosplenomegaly (HP:0001433)2.04276958
122Thoracic kyphosis (HP:0002942)2.03376558
123Restrictive lung disease (HP:0002091)2.01331633
124Vertigo (HP:0002321)1.98311056
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98216328
126Glomerulopathy (HP:0100820)1.94351699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.99461791
2KIT2.77125017
3BLK2.67334652
4TYK22.58894728
5TXK2.58768491
6EEF2K2.45025581
7CSF1R2.38324534
8ZAP702.35249089
9TBK12.33343924
10IRAK42.30392779
11BTK2.25766805
12JAK32.23825514
13PRPF4B2.21265582
14STK102.04336198
15SYK2.01162341
16TEC2.00000880
17IKBKE1.95620088
18MAP3K141.93877111
19ITK1.85803055
20TGFBR21.80465871
21FES1.75943362
22GRK61.75732837
23MAP3K101.73891887
24RIPK41.73437138
25ERN11.67770793
26PKN21.65743803
27HCK1.58505469
28MAP2K31.58364836
29JAK11.51935331
30NME21.48281118
31IRAK31.47599744
32GRK71.45924297
33* LCK1.40443389
34CLK11.40206212
35IKBKB1.39171598
36CSK1.37370399
37LRRK21.34831569
38FLT31.33598847
39TAOK31.32966413
40TAOK21.29179087
41BMPR21.28653236
42LYN1.27693637
43PIM11.11207938
44TRIB31.11207370
45RPS6KA41.08308824
46MAP3K131.07599688
47MAP3K11.06596004
48SIK21.01323744
49FGFR41.01203840
50NEK20.98733344
51SIK30.98646754
52EPHB10.96768708
53IRAK10.93794924
54FGFR30.92830647
55PIM20.91612957
56CDC42BPA0.86524843
57SCYL20.86154964
58CAMKK20.84403063
59JAK20.83082721
60MATK0.81961356
61STK40.81551168
62CDK40.80625395
63CAMKK10.77156416
64TESK20.74807276
65IRAK20.73378394
66MARK30.72125649
67CHUK0.71048450
68RPS6KB20.69491216
69NLK0.68525778
70KSR20.68421549
71KDR0.66773283
72MARK20.65355512
73CDK120.65046464
74MAP3K110.64414948
75YES10.61597198
76TGFBR10.60817945
77TRPM70.60666931
78PTK60.59791186
79MAPK70.58718215
80MAP3K50.57920726
81MAP3K80.57543686
82MAPK120.57515490
83PASK0.57254748
84CDC70.56212592
85PAK40.55460803
86MOS0.54553096
87PDPK10.53911840
88MAPK40.53696662
89MST40.52787202
90CDK60.52530096
91MAP2K60.52250712
92ADRBK20.51890148
93TNK20.51379071
94FYN0.51292902
95ATR0.50479838
96PRKCQ0.50098511
97RPS6KA60.48854713
98MAPKAPK30.48125874
99MAP3K30.46444203
100ALK0.46411323
101MAPKAPK20.45786917
102NEK90.45408119
103TSSK60.43650208
104HIPK20.42231483
105MAPK110.41523870
106TAOK10.41413637
107TTN0.40562104
108PRKD20.40316223
109PDK10.40228461
110CAMK1D0.40006041
111CDK90.38359032
112VRK10.37654577
113EGFR0.37134176
114PIK3CG0.36846457
115EIF2AK30.36605266
116RPS6KL10.36231512
117RPS6KC10.36231512
118FGR0.32200569
119EIF2AK10.32142027
120STK160.31676283
121MAP3K70.31352261
122PRKCD0.30695397
123DAPK20.29349441
124PRKCH0.29300352
125* ABL10.29157491
126ACVR1B0.27148725
127EPHA30.26775649
128MAP2K20.26506466
129SMG10.26252290
130STK110.25635379
131SGK30.25084652
132DYRK1B0.23679253
133MAP3K60.23381069

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.62430464
2Leishmaniasis_Homo sapiens_hsa051402.79423428
3* B cell receptor signaling pathway_Homo sapiens_hsa046622.65642329
4Antigen processing and presentation_Homo sapiens_hsa046122.44731635
5Osteoclast differentiation_Homo sapiens_hsa043802.42181573
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.42028363
7Measles_Homo sapiens_hsa051622.24217207
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13558542
9DNA replication_Homo sapiens_hsa030302.11295402
10Hematopoietic cell lineage_Homo sapiens_hsa046402.03881092
11* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02127592
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.99153803
13Staphylococcus aureus infection_Homo sapiens_hsa051501.87397182
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86723903
15Other glycan degradation_Homo sapiens_hsa005111.85768359
16* T cell receptor signaling pathway_Homo sapiens_hsa046601.76142319
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76042370
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75776232
19* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74271729
20Herpes simplex infection_Homo sapiens_hsa051681.73224489
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.67033359
22Legionellosis_Homo sapiens_hsa051341.55590131
23Tuberculosis_Homo sapiens_hsa051521.52661911
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51771525
25Pertussis_Homo sapiens_hsa051331.51104403
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.48619002
27* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48441681
28Influenza A_Homo sapiens_hsa051641.47347431
29Base excision repair_Homo sapiens_hsa034101.45300389
30Toxoplasmosis_Homo sapiens_hsa051451.44431613
31Allograft rejection_Homo sapiens_hsa053301.42385320
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41116858
33Shigellosis_Homo sapiens_hsa051311.39812215
34Ribosome_Homo sapiens_hsa030101.37210213
35Acute myeloid leukemia_Homo sapiens_hsa052211.35813894
36Mismatch repair_Homo sapiens_hsa034301.34804936
37Hepatitis B_Homo sapiens_hsa051611.33147820
38Apoptosis_Homo sapiens_hsa042101.32249007
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31290104
40Graft-versus-host disease_Homo sapiens_hsa053321.27541728
41Lysosome_Homo sapiens_hsa041421.26457584
42Malaria_Homo sapiens_hsa051441.24762095
43Non-homologous end-joining_Homo sapiens_hsa034501.21132747
44* Chemokine signaling pathway_Homo sapiens_hsa040621.20617682
45Asthma_Homo sapiens_hsa053101.17967270
46Chronic myeloid leukemia_Homo sapiens_hsa052201.16596754
47TNF signaling pathway_Homo sapiens_hsa046681.11193220
48* Leukocyte transendothelial migration_Homo sapiens_hsa046701.08889344
49Epstein-Barr virus infection_Homo sapiens_hsa051691.07666253
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07091135
51Platelet activation_Homo sapiens_hsa046111.06158755
52Viral myocarditis_Homo sapiens_hsa054161.01231174
53Salmonella infection_Homo sapiens_hsa051320.99191083
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97795757
55Pancreatic cancer_Homo sapiens_hsa052120.96439163
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93903449
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93338202
58Homologous recombination_Homo sapiens_hsa034400.93251021
59Viral carcinogenesis_Homo sapiens_hsa052030.90378751
60Spliceosome_Homo sapiens_hsa030400.90004682
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89848107
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83839364
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.82289407
64Hepatitis C_Homo sapiens_hsa051600.80930419
65HTLV-I infection_Homo sapiens_hsa051660.78113878
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77885744
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77675423
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77203794
69Non-small cell lung cancer_Homo sapiens_hsa052230.72684333
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68520139
71Caffeine metabolism_Homo sapiens_hsa002320.68126378
72Phagosome_Homo sapiens_hsa041450.66454341
73p53 signaling pathway_Homo sapiens_hsa041150.64835616
74Nucleotide excision repair_Homo sapiens_hsa034200.61475727
75Colorectal cancer_Homo sapiens_hsa052100.61291305
76VEGF signaling pathway_Homo sapiens_hsa043700.60395195
77Systemic lupus erythematosus_Homo sapiens_hsa053220.59962835
78Cell cycle_Homo sapiens_hsa041100.59868924
79Rheumatoid arthritis_Homo sapiens_hsa053230.58836015
80Pentose phosphate pathway_Homo sapiens_hsa000300.57986818
81Small cell lung cancer_Homo sapiens_hsa052220.57363736
82Autoimmune thyroid disease_Homo sapiens_hsa053200.54944107
83African trypanosomiasis_Homo sapiens_hsa051430.49909213
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49509775
85Prolactin signaling pathway_Homo sapiens_hsa049170.49228425
86One carbon pool by folate_Homo sapiens_hsa006700.46398767
87Collecting duct acid secretion_Homo sapiens_hsa049660.45350325
88Fanconi anemia pathway_Homo sapiens_hsa034600.45078366
89Notch signaling pathway_Homo sapiens_hsa043300.45026389
90Renal cell carcinoma_Homo sapiens_hsa052110.44862052
91Dorso-ventral axis formation_Homo sapiens_hsa043200.44567024
92N-Glycan biosynthesis_Homo sapiens_hsa005100.44086049
93Endocytosis_Homo sapiens_hsa041440.43779620
94Pyrimidine metabolism_Homo sapiens_hsa002400.43560832
95Type II diabetes mellitus_Homo sapiens_hsa049300.42635487
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42608244
97Type I diabetes mellitus_Homo sapiens_hsa049400.42475840
98HIF-1 signaling pathway_Homo sapiens_hsa040660.42018142
99Amoebiasis_Homo sapiens_hsa051460.41378935
100Prion diseases_Homo sapiens_hsa050200.38951313
101Bladder cancer_Homo sapiens_hsa052190.38460764
102MAPK signaling pathway_Homo sapiens_hsa040100.38321721
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.38054574
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.37641132
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36715937
106RNA transport_Homo sapiens_hsa030130.34192206
107GnRH signaling pathway_Homo sapiens_hsa049120.32818182
108RNA degradation_Homo sapiens_hsa030180.32682947
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32296817
110Sulfur relay system_Homo sapiens_hsa041220.30586287
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30403899
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30241841
113Inositol phosphate metabolism_Homo sapiens_hsa005620.29487625
114Insulin resistance_Homo sapiens_hsa049310.29317359
115mTOR signaling pathway_Homo sapiens_hsa041500.28091166
116FoxO signaling pathway_Homo sapiens_hsa040680.27551790
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.26136057
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23496930
119Choline metabolism in cancer_Homo sapiens_hsa052310.22334814
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21089440
121Complement and coagulation cascades_Homo sapiens_hsa046100.17742189
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16910413
123Prostate cancer_Homo sapiens_hsa052150.16496418
124Regulation of autophagy_Homo sapiens_hsa041400.15985754

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »