VAX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of body development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeobox gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)9.12357911
2diol metabolic process (GO:0034311)8.09767395
3exogenous drug catabolic process (GO:0042738)7.96802790
4sphingoid metabolic process (GO:0046519)7.81783333
5coronary vasculature morphogenesis (GO:0060977)7.66503072
6arginine catabolic process (GO:0006527)7.48761389
7negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.26520101
8sympathetic nervous system development (GO:0048485)6.93150873
9regulation of secondary heart field cardioblast proliferation (GO:0003266)6.76901707
10regulation of cardioblast proliferation (GO:0003264)6.76901707
11enteric nervous system development (GO:0048484)6.35760324
12drug catabolic process (GO:0042737)6.25525519
13peripheral nervous system neuron development (GO:0048935)5.96124696
14cardiac ventricle formation (GO:0003211)5.88876168
15regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.67525278
16cell migration involved in heart development (GO:0060973)5.53789903
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.50180544
18cell migration in hindbrain (GO:0021535)5.41924989
19negative regulation of striated muscle cell apoptotic process (GO:0010664)5.40840010
20DNA methylation involved in gamete generation (GO:0043046)5.40195016
21positive regulation of transcription regulatory region DNA binding (GO:2000679)5.37419507
22lipopolysaccharide biosynthetic process (GO:0009103)5.36041640
23cardiac chamber formation (GO:0003207)5.34704240
24paraxial mesoderm development (GO:0048339)5.27449962
25suckling behavior (GO:0001967)5.12728766
26protein-chromophore linkage (GO:0018298)5.10568013
27neuron cell-cell adhesion (GO:0007158)5.07332358
28regulation of cardiac muscle cell apoptotic process (GO:0010665)4.94562324
29tongue development (GO:0043586)4.94561993
30regulation of meiosis I (GO:0060631)4.88854463
31negative regulation of cell cycle G2/M phase transition (GO:1902750)4.75872713
32positive regulation of cell size (GO:0045793)4.65303933
33notochord development (GO:0030903)4.53101933
34sexual reproduction (GO:0019953)4.49171983
35meiotic chromosome segregation (GO:0045132)4.45627957
36sulfate transmembrane transport (GO:1902358)4.43334836
37lipopolysaccharide metabolic process (GO:0008653)4.41031422
38response to dietary excess (GO:0002021)4.40448342
39cartilage morphogenesis (GO:0060536)4.36039969
40nitric oxide mediated signal transduction (GO:0007263)4.33863519
41negative regulation of neurotransmitter transport (GO:0051589)4.24341275
42arginine metabolic process (GO:0006525)4.23552772
43positive regulation of developmental pigmentation (GO:0048087)4.17717831
44centriole replication (GO:0007099)4.16593932
45regulation of striated muscle cell apoptotic process (GO:0010662)4.15240946
46regulation of pigment cell differentiation (GO:0050932)4.14909877
47postsynaptic membrane organization (GO:0001941)4.11259815
48organ induction (GO:0001759)4.10408266
49regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.99567915
50mesenchymal cell proliferation (GO:0010463)3.98788213
51adult heart development (GO:0007512)3.95987456
52sulfate transport (GO:0008272)3.90431359
53layer formation in cerebral cortex (GO:0021819)3.89055209
54negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.85746442
55cell proliferation in forebrain (GO:0021846)3.84895033
56positive regulation of guanylate cyclase activity (GO:0031284)3.81862734
57G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.75433522
58synaptic vesicle maturation (GO:0016188)3.75162957
59regulation of protein glycosylation (GO:0060049)3.73036329
60negative regulation of calcium ion transport into cytosol (GO:0010523)3.72965619
61innervation (GO:0060384)3.71572439
62heme transport (GO:0015886)3.67171552
63regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66238143
64apoptotic process involved in morphogenesis (GO:0060561)3.63232987
65negative regulation of sodium ion transport (GO:0010766)3.60977530
66planar cell polarity pathway involved in neural tube closure (GO:0090179)3.59548879
67piRNA metabolic process (GO:0034587)3.57235731
68ribonucleoprotein complex disassembly (GO:0032988)3.57118555
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.55310327
70dopaminergic neuron differentiation (GO:0071542)3.44135701
71neural crest cell development (GO:0014032)3.42821494
72neuron fate determination (GO:0048664)3.38828617
73regulation of guanylate cyclase activity (GO:0031282)3.38132504
74gamma-aminobutyric acid transport (GO:0015812)3.37036352
75epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.35617393
76regulation of heart morphogenesis (GO:2000826)3.34903237
77embryonic skeletal joint morphogenesis (GO:0060272)3.34342150
78neural crest cell migration (GO:0001755)3.33443691
79regulation of neurotransmitter uptake (GO:0051580)3.32538537
80response to nitrosative stress (GO:0051409)3.30013108
81regulation of respiratory gaseous exchange (GO:0043576)3.29389953
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.28099851
83glutamine family amino acid catabolic process (GO:0009065)3.27990237
84low-density lipoprotein particle remodeling (GO:0034374)3.26843122
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24763212
86limb development (GO:0060173)3.22317890
87appendage development (GO:0048736)3.22317890
88locomotory exploration behavior (GO:0035641)3.21943569
89nonmotile primary cilium assembly (GO:0035058)3.19087278
90developmental induction (GO:0031128)3.17026276
91olfactory bulb development (GO:0021772)3.14042039
92dorsal/ventral pattern formation (GO:0009953)3.13650359
93regulation of rhodopsin mediated signaling pathway (GO:0022400)3.13410909
94cell-cell signaling involved in cell fate commitment (GO:0045168)3.11953726
95positive regulation of glomerulus development (GO:0090193)3.11836271
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09491461
97central nervous system myelination (GO:0022010)3.07583801
98axon ensheathment in central nervous system (GO:0032291)3.07583801
99apoptotic process involved in development (GO:1902742)3.05035321
100tachykinin receptor signaling pathway (GO:0007217)3.04483000
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03941235
102mesenchymal cell development (GO:0014031)3.03225121
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02978420
104cellular response to prostaglandin stimulus (GO:0071379)3.02066094
105dorsal/ventral axis specification (GO:0009950)3.02046501
106organelle disassembly (GO:1903008)2.98215170
107iron coordination entity transport (GO:1901678)2.97372144
108SMAD protein complex assembly (GO:0007183)2.95623937
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94002285
110L-phenylalanine catabolic process (GO:0006559)2.94002285
111stem cell development (GO:0048864)2.93968369
112positive regulation of cGMP metabolic process (GO:0030825)2.93725441
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.91929595
114cerebral cortex neuron differentiation (GO:0021895)2.91558484
115positive regulation of extracellular matrix organization (GO:1903055)2.91239107
116proximal/distal pattern formation (GO:0009954)2.89278187
117tyrosine metabolic process (GO:0006570)2.88344737
118peptidyl-proline hydroxylation (GO:0019511)2.88096053
119negative regulation of oligodendrocyte differentiation (GO:0048715)2.86915915
120somite development (GO:0061053)2.84517150
121generation of neurons (GO:0048699)2.84325147
122snRNA transcription (GO:0009301)2.82563675
123epithelial cilium movement (GO:0003351)2.82471613
124negative regulation of glycoprotein biosynthetic process (GO:0010561)2.82452403
125regulation of cholesterol esterification (GO:0010872)2.81911203
126retinal ganglion cell axon guidance (GO:0031290)2.80642550
127skeletal muscle organ development (GO:0060538)2.79955681
128DNA damage induced protein phosphorylation (GO:0006975)2.79644647
129rhodopsin mediated signaling pathway (GO:0016056)2.78452166
130cellular sodium ion homeostasis (GO:0006883)2.77620225
131microtubule severing (GO:0051013)2.77374750
132left/right axis specification (GO:0070986)2.77314914
133lateral sprouting from an epithelium (GO:0060601)2.77289198
134response to parathyroid hormone (GO:0071107)2.77103671
135regulation of activation of Janus kinase activity (GO:0010533)2.73821177
136protein polyglutamylation (GO:0018095)2.73404984
137glycerol metabolic process (GO:0006071)2.73240409
138intraciliary transport (GO:0042073)2.71668085
139kidney morphogenesis (GO:0060993)2.70458093
140heart valve formation (GO:0003188)2.69232876
1414-hydroxyproline metabolic process (GO:0019471)2.69060162
142cerebellar Purkinje cell layer development (GO:0021680)2.68401580
143non-canonical Wnt signaling pathway (GO:0035567)2.67797923
144alanine transport (GO:0032328)2.66549035
145negative regulation of systemic arterial blood pressure (GO:0003085)2.66536928
146regulation of cholesterol biosynthetic process (GO:0045540)2.66284273
147positive regulation of cGMP biosynthetic process (GO:0030828)2.66070726
148pyrimidine nucleobase catabolic process (GO:0006208)2.65521074
149positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64902273
150regulation of organ formation (GO:0003156)2.64883689
151regulation of development, heterochronic (GO:0040034)2.64235852
152cerebellar granule cell differentiation (GO:0021707)2.64206130
153positive regulation of meiosis (GO:0045836)2.64201763
154biotin metabolic process (GO:0006768)2.63466402
155negative regulation of glial cell differentiation (GO:0045686)2.63430516
156lung-associated mesenchyme development (GO:0060484)2.63304586
157spinal cord association neuron differentiation (GO:0021527)2.63042554
158myoblast fusion (GO:0007520)2.61839577
159drinking behavior (GO:0042756)2.61695490
160neuromuscular process controlling balance (GO:0050885)2.60768485
161cilium movement (GO:0003341)2.60687662
162somite rostral/caudal axis specification (GO:0032525)2.60318825
163sodium ion export (GO:0071436)2.57640791
164positive regulation of sodium ion transmembrane transport (GO:1902307)2.57285208
165body morphogenesis (GO:0010171)2.56600389
166regulation of cGMP metabolic process (GO:0030823)2.56416823
167mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.55381220
168negative regulation of muscle cell apoptotic process (GO:0010656)2.55375241
169polarized epithelial cell differentiation (GO:0030859)2.53779687
170negative regulation of mast cell activation (GO:0033004)2.53537220
171resolution of meiotic recombination intermediates (GO:0000712)2.53193653
172response to folic acid (GO:0051593)2.53056719
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.52864394
174regulation of timing of cell differentiation (GO:0048505)2.52280669
175serotonin receptor signaling pathway (GO:0007210)2.51690538
176centriole assembly (GO:0098534)2.51340698
177nodal signaling pathway (GO:0038092)2.50659516
178cell differentiation in hindbrain (GO:0021533)2.49275256
179cell communication by electrical coupling (GO:0010644)2.48817818
180aspartate family amino acid catabolic process (GO:0009068)2.48781354
181neurotransmitter secretion (GO:0007269)2.48187078
182positive regulation of cAMP-mediated signaling (GO:0043950)2.47980976
183regulation of nuclear cell cycle DNA replication (GO:0033262)2.47602684
184calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47512718
185regulation of feeding behavior (GO:0060259)2.46920845
186auditory behavior (GO:0031223)2.46514412
187positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.45882259
188regulation of cGMP biosynthetic process (GO:0030826)2.45779587
189dorsal/ventral neural tube patterning (GO:0021904)2.45434749
190positive regulation of meiotic cell cycle (GO:0051446)2.42607665
191aromatic amino acid family catabolic process (GO:0009074)2.42584219
192indolalkylamine metabolic process (GO:0006586)2.42541197
193alditol metabolic process (GO:0019400)2.39492689
194positive regulation of heat generation (GO:0031652)2.39083463
195C4-dicarboxylate transport (GO:0015740)2.38737640
196regulation of dopamine secretion (GO:0014059)2.38290402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.02246065
2IGF1R_20145208_ChIP-Seq_DFB_Human3.98061778
3AR_21572438_ChIP-Seq_LNCaP_Human3.28489196
4* JARID2_20075857_ChIP-Seq_MESCs_Mouse3.03711485
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00579846
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.93653342
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.93301943
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.93301943
9* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.91998215
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.80714379
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.79845776
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67438244
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.61518647
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52222141
15* EZH2_27294783_Chip-Seq_ESCs_Mouse2.50841009
16* RNF2_27304074_Chip-Seq_ESCs_Mouse2.47490826
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47221664
18ERG_21242973_ChIP-ChIP_JURKAT_Human2.44223396
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42804572
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34303112
21* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30884457
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.29911455
23* EED_16625203_ChIP-ChIP_MESCs_Mouse2.28908653
24* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27913108
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27319081
26TP63_19390658_ChIP-ChIP_HaCaT_Human2.26860827
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25156267
28* RING1B_27294783_Chip-Seq_NPCs_Mouse2.20775399
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20706643
30KDM2B_26808549_Chip-Seq_K562_Human2.20544282
31DROSHA_22980978_ChIP-Seq_HELA_Human2.18011710
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17177929
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14785737
34* RING1B_27294783_Chip-Seq_ESCs_Mouse2.13429778
35RARB_27405468_Chip-Seq_BRAIN_Mouse2.11371830
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.11137028
37ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10216323
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10064889
39* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.06268519
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03981963
41* TP53_20018659_ChIP-ChIP_R1E_Mouse2.02183821
42STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00682956
43GBX2_23144817_ChIP-Seq_PC3_Human2.00584747
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98979813
45* P300_19829295_ChIP-Seq_ESCs_Human1.98595719
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.96615804
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94605140
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89567090
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87331104
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84904461
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84429226
52REST_21632747_ChIP-Seq_MESCs_Mouse1.82536718
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81824293
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.80558149
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80497579
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80141911
57* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77794044
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77497984
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72377822
60KDM2B_26808549_Chip-Seq_DND41_Human1.72320990
61FUS_26573619_Chip-Seq_HEK293_Human1.68115649
62* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65437923
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65048092
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65048092
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63538965
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.63440241
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61700251
68* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56185581
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.54448970
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53652912
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.52235719
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52019814
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51570236
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.50945365
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50124327
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.49345213
77LXR_22292898_ChIP-Seq_THP-1_Human1.49222757
78TAF15_26573619_Chip-Seq_HEK293_Human1.48683252
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47812787
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47089929
81CTCF_27219007_Chip-Seq_Bcells_Human1.46332528
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44595357
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43138151
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42642846
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.41950476
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39004109
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37924782
88ZNF274_21170338_ChIP-Seq_K562_Hela1.37754195
89* RNF2_27304074_Chip-Seq_NSC_Mouse1.36074417
90VDR_22108803_ChIP-Seq_LS180_Human1.35750743
91ER_23166858_ChIP-Seq_MCF-7_Human1.35491217
92DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34231379
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33511820
94STAT3_23295773_ChIP-Seq_U87_Human1.33094541
95EWS_26573619_Chip-Seq_HEK293_Human1.29574686
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29377712
97IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28564739
98CBP_20019798_ChIP-Seq_JUKART_Human1.28268768
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28268768
100NANOG_19829295_ChIP-Seq_ESCs_Human1.27909842
101SOX2_19829295_ChIP-Seq_ESCs_Human1.27909842
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.25409318
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25244730
104SMAD4_21799915_ChIP-Seq_A2780_Human1.25099834
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23958356
106AR_25329375_ChIP-Seq_VCAP_Human1.23911190
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22841031
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20125603
109IRF1_19129219_ChIP-ChIP_H3396_Human1.18800155
110* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18684237
111* HOXB7_26014856_ChIP-Seq_BT474_Human1.18520635
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18419669
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.18116338
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17890509
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16984473
116CREB1_26743006_Chip-Seq_LNCaP_Human1.16353547
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16342196
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16296616
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16029458
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15592345
121* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15262707
122* TCF4_23295773_ChIP-Seq_U87_Human1.14584598
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13370354
124AR_19668381_ChIP-Seq_PC3_Human1.13033613
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12742968
126TCF4_22108803_ChIP-Seq_LS180_Human1.12324260
127STAT3_18555785_ChIP-Seq_MESCs_Mouse1.12308868
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12098553
129TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11641147
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10661824
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.09713173
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07750788
133RACK7_27058665_Chip-Seq_MCF-7_Human1.07301064
134AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06838448
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06629282
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06412661
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06191413
138SMAD3_21741376_ChIP-Seq_ESCs_Human1.05464153
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05362477
140GATA3_21878914_ChIP-Seq_MCF-7_Human1.04626109
141NCOR_22424771_ChIP-Seq_293T_Human1.04618638
142SOX9_26525672_Chip-Seq_HEART_Mouse1.04487342
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03389403
144SMAD3_21741376_ChIP-Seq_EPCs_Human1.02992848
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02697050
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02621692
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01520552
148SA1_27219007_Chip-Seq_ERYTHROID_Human1.00665809
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00493574
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99922209
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.98897943
152ESR2_21235772_ChIP-Seq_MCF-7_Human0.93805568
153ZNF263_19887448_ChIP-Seq_K562_Human0.91138272
154CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90892199
155SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89915658
156* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88900347
157NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88578661
158TET1_21490601_ChIP-Seq_MESCs_Mouse0.86976799
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86478367
160* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86088407
161VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84848720
162POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84419526
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83762258
164SOX3_22085726_ChIP-Seq_NPCs_Mouse0.83718530
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83393348
166RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82731479
167CLOCK_20551151_ChIP-Seq_293T_Human0.82337502
168DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80714621
169CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80477301
170TCF7_22412390_ChIP-Seq_EML_Mouse0.80196643
171YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79521238
172NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79233300
173CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76743573
174WDR5_24793694_ChIP-Seq_LNCAP_Human0.75267564
175SOX2_21211035_ChIP-Seq_LN229_Gbm0.75029886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.42321206
2MP0003136_yellow_coat_color6.27771184
3MP0005171_absent_coat_pigmentation5.78423544
4MP0004858_abnormal_nervous_system5.17525702
5MP0005167_abnormal_blood-brain_barrier3.75317700
6MP0003890_abnormal_embryonic-extraembry3.69555453
7MP0006292_abnormal_olfactory_placode3.43976433
8MP0003646_muscle_fatigue3.41698738
9MP0004859_abnormal_synaptic_plasticity3.17790134
10MP0002751_abnormal_autonomic_nervous2.99807979
11MP0005645_abnormal_hypothalamus_physiol2.88534796
12MP0004043_abnormal_pH_regulation2.84969683
13MP0000569_abnormal_digit_pigmentation2.64927255
14MP0002938_white_spotting2.58103742
15MP0003123_paternal_imprinting2.49457548
16MP0004233_abnormal_muscle_weight2.40658244
17MP0003122_maternal_imprinting2.38952313
18MP0003879_abnormal_hair_cell2.37785310
19MP0003635_abnormal_synaptic_transmissio2.28565127
20MP0000534_abnormal_ureter_morphology2.27229526
21MP0008789_abnormal_olfactory_epithelium2.25337649
22MP0000049_abnormal_middle_ear2.23203656
23MP0005423_abnormal_somatic_nervous2.19222812
24MP0006138_congestive_heart_failure2.15508594
25MP0002102_abnormal_ear_morphology2.01435405
26MP0006072_abnormal_retinal_apoptosis1.97517463
27* MP0000778_abnormal_nervous_system1.94449645
28MP0003329_amyloid_beta_deposits1.93120131
29MP0005670_abnormal_white_adipose1.92191224
30MP0003567_abnormal_fetal_cardiomyocyte1.90351080
31MP0002909_abnormal_adrenal_gland1.88800532
32MP0002127_abnormal_cardiovascular_syste1.85733357
33MP0003787_abnormal_imprinting1.83528663
34MP0002638_abnormal_pupillary_reflex1.83336866
35MP0003942_abnormal_urinary_system1.82716183
36MP0001502_abnormal_circadian_rhythm1.79201677
37MP0003075_altered_response_to1.76554094
38MP0009745_abnormal_behavioral_response1.67970658
39MP0002163_abnormal_gland_morphology1.65256760
40MP0002063_abnormal_learning/memory/cond1.64932638
41MP0003045_fibrosis1.63233042
42MP0000955_abnormal_spinal_cord1.60545753
43MP0004084_abnormal_cardiac_muscle1.60419802
44MP0004270_analgesia1.56584331
45MP0002064_seizures1.52999074
46MP0002184_abnormal_innervation1.52846210
47MP0009780_abnormal_chondrocyte_physiolo1.48577842
48MP0004885_abnormal_endolymph1.45909978
49MP0005257_abnormal_intraocular_pressure1.43961097
50MP0005377_hearing/vestibular/ear_phenot1.42195798
51MP0003878_abnormal_ear_physiology1.42195798
52MP0004142_abnormal_muscle_tone1.40363329
53MP0004147_increased_porphyrin_level1.40255990
54MP0001299_abnormal_eye_distance/1.38734714
55MP0001440_abnormal_grooming_behavior1.36505815
56MP0008961_abnormal_basal_metabolism1.36093256
57MP0002822_catalepsy1.34883864
58MP0009384_cardiac_valve_regurgitation1.34755160
59MP0002095_abnormal_skin_pigmentation1.34030426
60MP0004811_abnormal_neuron_physiology1.33290688
61MP0004381_abnormal_hair_follicle1.33225227
62MP0002234_abnormal_pharynx_morphology1.32841784
63MP0000762_abnormal_tongue_morphology1.30281765
64MP0010030_abnormal_orbit_morphology1.30267646
65MP0001293_anophthalmia1.29868625
66MP0002249_abnormal_larynx_morphology1.29374092
67MP0005197_abnormal_uvea_morphology1.28531827
68MP0004883_abnormal_blood_vessel1.24235128
69MP0000427_abnormal_hair_cycle1.23128856
70* MP0002653_abnormal_ependyma_morphology1.22586324
71MP0002557_abnormal_social/conspecific_i1.21293530
72MP0001664_abnormal_digestion1.21230310
73MP0003195_calcinosis1.19836772
74MP0000538_abnormal_urinary_bladder1.19123953
75MP0001984_abnormal_olfaction1.19112006
76MP0002572_abnormal_emotion/affect_behav1.17899584
77MP0001501_abnormal_sleep_pattern1.16907312
78MP0005623_abnormal_meninges_morphology1.15057494
79MP0001270_distended_abdomen1.14467126
80MP0006054_spinal_hemorrhage1.14261951
81MP0002138_abnormal_hepatobiliary_system1.13339194
82* MP0002882_abnormal_neuron_morphology1.12149114
83MP0009840_abnormal_foam_cell1.10468749
84MP0009046_muscle_twitch1.08474908
85MP0002089_abnormal_postnatal_growth/wei1.08132759
86MP0000026_abnormal_inner_ear1.06484054
87MP0008775_abnormal_heart_ventricle1.05027619
88MP0002160_abnormal_reproductive_system1.03641905
89MP0001849_ear_inflammation1.02231222
90MP0003880_abnormal_central_pattern1.01888610
91MP0000467_abnormal_esophagus_morphology1.01495546
92MP0003634_abnormal_glial_cell1.01188600
93* MP0002152_abnormal_brain_morphology0.99587751
94MP0000639_abnormal_adrenal_gland0.97948876
95* MP0003861_abnormal_nervous_system0.97179944
96MP0002733_abnormal_thermal_nociception0.96122834
97MP0003137_abnormal_impulse_conducting0.96042295
98MP0002272_abnormal_nervous_system0.95951699
99MP0001486_abnormal_startle_reflex0.95803377
100MP0002075_abnormal_coat/hair_pigmentati0.95711184
101MP0002168_other_aberrant_phenotype0.95417240
102MP0005085_abnormal_gallbladder_physiolo0.95160923
103MP0004036_abnormal_muscle_relaxation0.94708293
104MP0003121_genomic_imprinting0.94360869
105MP0005646_abnormal_pituitary_gland0.93958596
106* MP0003755_abnormal_palate_morphology0.90875109
107MP0005248_abnormal_Harderian_gland0.90607658
108MP0006276_abnormal_autonomic_nervous0.89976294
109MP0004484_altered_response_of0.89690994
110MP0003632_abnormal_nervous_system0.89690358
111MP0003633_abnormal_nervous_system0.89064286
112MP0003172_abnormal_lysosome_physiology0.89005257
113MP0000631_abnormal_neuroendocrine_gland0.88966769
114MP0005551_abnormal_eye_electrophysiolog0.87628895
115MP0001963_abnormal_hearing_physiology0.87559481
116MP0001485_abnormal_pinna_reflex0.87509392
117MP0003115_abnormal_respiratory_system0.84595752
118MP0005499_abnormal_olfactory_system0.84399429
119MP0005394_taste/olfaction_phenotype0.84399429
120MP0003631_nervous_system_phenotype0.84332359
121MP0001348_abnormal_lacrimal_gland0.84001406
122MP0003937_abnormal_limbs/digits/tail_de0.83768904
123MP0004130_abnormal_muscle_cell0.83368033
124MP0005253_abnormal_eye_physiology0.82674074
125MP0008872_abnormal_physiological_respon0.82402006
126MP0005075_abnormal_melanosome_morpholog0.82228411
127MP0000749_muscle_degeneration0.81194008
128MP0004133_heterotaxia0.80289747
129MP0001529_abnormal_vocalization0.79342973
130* MP0001286_abnormal_eye_development0.79242764
131MP0003690_abnormal_glial_cell0.77621935
132MP0002233_abnormal_nose_morphology0.77072217
133MP0002277_abnormal_respiratory_mucosa0.76925507
134MP0004742_abnormal_vestibular_system0.76024027
135MP0002972_abnormal_cardiac_muscle0.75491575
136MP0005379_endocrine/exocrine_gland_phen0.74891040
137MP0000604_amyloidosis0.74019682
138MP0002734_abnormal_mechanical_nocicepti0.74014012
139MP0002069_abnormal_eating/drinking_beha0.73949436
140MP0001324_abnormal_eye_pigmentation0.73689898
141MP0002735_abnormal_chemical_nociception0.73679098
142MP0002066_abnormal_motor_capabilities/c0.73181534
143* MP0002752_abnormal_somatic_nervous0.72444741
144MP0001970_abnormal_pain_threshold0.72085665
145MP0001968_abnormal_touch/_nociception0.72068904
146MP0003868_abnormal_feces_composition0.72052470
147MP0009250_abnormal_appendicular_skeleto0.71864714
148MP0000428_abnormal_craniofacial_morphol0.71377427
149* MP0002116_abnormal_craniofacial_bone0.71178451
150MP0008770_decreased_survivor_rate0.68518865
151MP0009053_abnormal_anal_canal0.68374762
152MP0001186_pigmentation_phenotype0.67903011
153MP0005174_abnormal_tail_pigmentation0.66461282
154* MP0005195_abnormal_posterior_eye0.64628987
155MP0002736_abnormal_nociception_after0.63480241
156MP0008932_abnormal_embryonic_tissue0.61405338
157MP0005391_vision/eye_phenotype0.61233240
158MP0002697_abnormal_eye_size0.60139465
159MP0005395_other_phenotype0.59168127

Predicted human phenotypes

RankGene SetZ-score
1Facial shape deformation (HP:0011334)6.89329343
2Potter facies (HP:0002009)6.89329343
3Focal motor seizures (HP:0011153)6.10408880
4Pheochromocytoma (HP:0002666)5.27151925
5Hypercortisolism (HP:0001578)5.05199737
6Amelogenesis imperfecta (HP:0000705)4.82807225
7Abnormality of the parathyroid morphology (HP:0011766)4.78829874
8Colon cancer (HP:0003003)4.59663966
9Pancreatic cysts (HP:0001737)4.48464961
10Parakeratosis (HP:0001036)4.47715406
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.46480185
12Neuroendocrine neoplasm (HP:0100634)4.33528073
13Acanthocytosis (HP:0001927)4.17148523
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.00810823
15Abnormality of calcium-phosphate metabolism (HP:0100530)3.99460795
16True hermaphroditism (HP:0010459)3.93428609
17Pancreatic fibrosis (HP:0100732)3.87346229
18Amblyopia (HP:0000646)3.80184503
19Agitation (HP:0000713)3.72148346
20Nephronophthisis (HP:0000090)3.72105233
21Hyperacusis (HP:0010780)3.70922252
22Hyperthyroidism (HP:0000836)3.65761426
23Hypoventilation (HP:0002791)3.59300836
24Hyperparathyroidism (HP:0000843)3.58939214
25Failure to thrive in infancy (HP:0001531)3.43152637
26Enlarged penis (HP:0000040)3.42961847
27Large eyes (HP:0001090)3.39286508
28Aplasia/Hypoplasia of the uvula (HP:0010293)3.35604636
29Insomnia (HP:0100785)3.28948826
30Abnormality of the renal medulla (HP:0100957)3.25917019
31Dialeptic seizures (HP:0011146)3.16977953
32Bicornuate uterus (HP:0000813)3.08962069
33Bowel diverticulosis (HP:0005222)3.08782105
34Neoplasm of the peripheral nervous system (HP:0100007)3.04607714
35Mesangial abnormality (HP:0001966)2.98975569
36Cystic liver disease (HP:0006706)2.96162198
37Abnormality of midbrain morphology (HP:0002418)2.94854391
38Molar tooth sign on MRI (HP:0002419)2.94854391
39Abnormality of the aortic arch (HP:0012303)2.91502536
40Neurofibrillary tangles (HP:0002185)2.89999456
41Ankyloglossia (HP:0010296)2.85009786
42Cerebral inclusion bodies (HP:0100314)2.83378093
43Elfin facies (HP:0004428)2.74714602
44Renal duplication (HP:0000075)2.73949018
45Anencephaly (HP:0002323)2.72286050
46Depression (HP:0000716)2.72039151
47Rectal prolapse (HP:0002035)2.70382255
48Widely patent fontanelles and sutures (HP:0004492)2.69300653
49Proximal amyotrophy (HP:0007126)2.68892668
50Erythroderma (HP:0001019)2.68708083
51Focal seizures (HP:0007359)2.68090509
52Menstrual irregularities (HP:0000858)2.67200739
53Hypoplastic pelvis (HP:0008839)2.67093759
54Synostosis of carpal bones (HP:0005048)2.65522541
55Cerebral hemorrhage (HP:0001342)2.63643831
56Megalencephaly (HP:0001355)2.62390970
57Myokymia (HP:0002411)2.61576968
58Overriding aorta (HP:0002623)2.58273827
59Exotropia (HP:0000577)2.55990517
60Macroorchidism (HP:0000053)2.49273733
61Pendular nystagmus (HP:0012043)2.49241669
62Wide cranial sutures (HP:0010537)2.48820490
63Abnormality of the 4th metacarpal (HP:0010012)2.47730870
64Postaxial foot polydactyly (HP:0001830)2.43625301
65Irregular epiphyses (HP:0010582)2.42874486
66Chronic hepatic failure (HP:0100626)2.42337853
67Medial flaring of the eyebrow (HP:0010747)2.40655275
68Abnormality of the diencephalon (HP:0010662)2.40570381
69Restlessness (HP:0000711)2.40047450
70Chin dimple (HP:0010751)2.39794451
71Nephrogenic diabetes insipidus (HP:0009806)2.39737759
72Renovascular hypertension (HP:0100817)2.39021337
73Hyperglycinemia (HP:0002154)2.38770287
74Supranuclear gaze palsy (HP:0000605)2.35403042
75Abnormality of binocular vision (HP:0011514)2.34967708
76Diplopia (HP:0000651)2.34967708
77Hypoplastic iliac wings (HP:0002866)2.32021785
78Aplasia/Hypoplasia of the tongue (HP:0010295)2.31986527
79Cerebellar dysplasia (HP:0007033)2.31485582
80Annular pancreas (HP:0001734)2.30054593
81Sclerocornea (HP:0000647)2.29936648
82Hemiparesis (HP:0001269)2.29356120
83Scapular winging (HP:0003691)2.29039649
84Hypercalcemia (HP:0003072)2.28690393
85Congenital ichthyosiform erythroderma (HP:0007431)2.27965796
86Bronchomalacia (HP:0002780)2.27637525
87Gait imbalance (HP:0002141)2.26101212
88Abnormality of the renal cortex (HP:0011035)2.22843684
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22227191
90Occipital encephalocele (HP:0002085)2.20129863
91Oligodactyly (hands) (HP:0001180)2.17574247
92Adrenal overactivity (HP:0002717)2.17509651
93Adducted thumb (HP:0001181)2.17497975
94Tubular atrophy (HP:0000092)2.15861367
95Congenital primary aphakia (HP:0007707)2.15272514
96Carpal synostosis (HP:0009702)2.14926336
97Abnormal ciliary motility (HP:0012262)2.13845314
98Hematochezia (HP:0002573)2.13059777
99Split foot (HP:0001839)2.12923079
100Striae distensae (HP:0001065)2.11768100
101Disproportionate tall stature (HP:0001519)2.11020358
102Primitive neuroectodermal tumor (HP:0030065)2.10785233
103Neuroblastic tumors (HP:0004376)2.10785233
104Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.10785233
105Neuroblastoma (HP:0003006)2.10785233
106Septo-optic dysplasia (HP:0100842)2.10445107
107Abnormality of the corticospinal tract (HP:0002492)2.09834701
108Action tremor (HP:0002345)2.09675747
109Goiter (HP:0000853)2.09455600
110Progressive cerebellar ataxia (HP:0002073)2.08290378
111Overlapping toe (HP:0001845)2.06961439
112Retinitis pigmentosa (HP:0000510)2.05896738
113Congenital hepatic fibrosis (HP:0002612)2.05031099
114Ulnar deviation of finger (HP:0009465)2.04520539
115Aplasia/Hypoplasia of the tibia (HP:0005772)2.04033050
116Abnormality of oral frenula (HP:0000190)2.03843217
117Ulnar claw (HP:0001178)2.02706314
118Flat cornea (HP:0007720)2.02382425
119Aplastic anemia (HP:0001915)2.02324710
120Rhabdomyosarcoma (HP:0002859)2.02119019
121Vertebral arch anomaly (HP:0008438)2.00210473
122Pointed chin (HP:0000307)2.00151661
123Shallow orbits (HP:0000586)1.96355078
124Testicular neoplasm (HP:0010788)1.95667277
125Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.94840319
126Humeroradial synostosis (HP:0003041)1.94172951
127Synostosis involving the elbow (HP:0003938)1.94172951
128Oligodactyly (HP:0012165)1.93274700
129J-shaped sella turcica (HP:0002680)1.93226615
130Postural tremor (HP:0002174)1.92895786
131Intestinal polyposis (HP:0200008)1.92894302
132Vitreoretinal degeneration (HP:0000655)1.92107290
133Short foot (HP:0001773)1.91772073
134Fibular hypoplasia (HP:0003038)1.91257734
135Ankle clonus (HP:0011448)1.90550715
136Neoplasm of the thyroid gland (HP:0100031)1.89251707
137Thyroid carcinoma (HP:0002890)1.89194922
138Radial bowing (HP:0002986)1.89184241
139Growth hormone excess (HP:0000845)1.88122442
140Neoplasm of striated muscle (HP:0009728)1.88119678
141Abnormality of macular pigmentation (HP:0008002)1.86596126
142Spastic diplegia (HP:0001264)1.86494629
143Vertebral hypoplasia (HP:0008417)1.86219925
144Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86219925
145Truncus arteriosus (HP:0001660)1.85556891
146Fibular aplasia (HP:0002990)1.84022520
147Dyskinesia (HP:0100660)1.83875675
148Holoprosencephaly (HP:0001360)1.82814851
149Type II lissencephaly (HP:0007260)1.81987184
150Turricephaly (HP:0000262)1.79686224
151Intestinal polyp (HP:0005266)1.78780080
152Precocious puberty (HP:0000826)1.78629512
153Enlarged kidneys (HP:0000105)1.78564339
154Increased nuchal translucency (HP:0010880)1.78054376
155Genital tract atresia (HP:0001827)1.77785380
156Vaginal atresia (HP:0000148)1.76653437
157Broad ribs (HP:0000885)1.76594346
158Renal dysplasia (HP:0000110)1.75241214
159Synostosis involving bones of the hand (HP:0004278)1.74019989
160Preaxial hand polydactyly (HP:0001177)1.72335794
161Male pseudohermaphroditism (HP:0000037)1.72311777
162Dandy-Walker malformation (HP:0001305)1.72110883
163Short humerus (HP:0005792)1.71768745
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70923662
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.69664489
166Hyperglycinuria (HP:0003108)1.68741826
167Psychosis (HP:0000709)1.68081430
168Optic nerve hypoplasia (HP:0000609)1.67761750
169Bladder diverticulum (HP:0000015)1.67690817
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67593662
171Short 4th metacarpal (HP:0010044)1.67593662
172Ectopic kidney (HP:0000086)1.67555690
173Abnormality of the humerus (HP:0003063)1.67289203
174Abnormality of the pubic bones (HP:0003172)1.66663708
175Abnormality of the upper arm (HP:0001454)1.65384372
176Congenital stationary night blindness (HP:0007642)1.65201812
177Cholecystitis (HP:0001082)1.65146907
178Abnormal gallbladder physiology (HP:0012438)1.65146907
179Postaxial hand polydactyly (HP:0001162)1.64815349
180Aqueductal stenosis (HP:0002410)1.64811346
181Urinary bladder sphincter dysfunction (HP:0002839)1.64706581
182Synostosis involving bones of the feet (HP:0009140)1.64256987
183Synostosis involving bones of the lower limbs (HP:0009138)1.64256987
184Anxiety (HP:0000739)1.64146742
185Neuroepithelial neoplasm (HP:0030063)1.64052720
186Sloping forehead (HP:0000340)1.63282306
187Supernumerary spleens (HP:0009799)1.61894519
188Aplasia/hypoplasia of the humerus (HP:0006507)1.61814988
189Tarsal synostosis (HP:0008368)1.60742972
190Patellar aplasia (HP:0006443)1.60478927
191Aplasia/Hypoplasia of the patella (HP:0006498)1.60456759
192Poor coordination (HP:0002370)1.59725993
193Adrenal hypoplasia (HP:0000835)1.59341140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.83823897
2STK38L6.41905844
3MAP3K93.37991825
4ZAK3.12997199
5MARK13.09908234
6FLT33.05833911
7NTRK13.05733092
8SIK12.83962124
9PTK22.54268910
10ALK2.49833158
11PKN22.46720223
12PDGFRA2.40438733
13EEF2K2.39325214
14FRK2.36937863
15TNIK2.29598758
16RET2.26276981
17TESK22.25788654
18CAMK42.20219304
19NTRK22.18787618
20STK32.17184948
21PINK12.05868278
22ACVR1B1.95734085
23BMPR1B1.94036859
24NLK1.92276057
25DAPK21.88676669
26TYRO31.86663013
27SCYL21.86068078
28STK381.83326875
29RIPK11.79285253
30MAP2K21.72249190
31CAMK11.71664654
32DDR21.64710032
33CAMK1G1.64432760
34PRKD31.63585859
35UHMK11.62239363
36PAK61.61073982
37MELK1.61058778
38MET1.55069828
39ICK1.54382630
40CAMK1D1.50644593
41KSR21.48733924
42CCNB11.45387863
43PDGFRB1.36185486
44TTK1.32439600
45EPHA41.26377329
46WNK31.21509860
47NTRK31.20393703
48LIMK11.18074365
49TRIB31.13762373
50ROCK11.13678350
51MKNK21.11670459
52MAP3K41.09498573
53NEK11.08669441
54CDC71.05829614
55LATS21.04867591
56NME11.02868014
57CDC42BPA1.02543371
58MINK11.00167979
59GRK70.98965454
60MAP4K20.98814288
61SIK20.98566952
62TAF10.96582202
63MAP2K70.95654991
64DYRK1B0.95275554
65RPS6KC10.93878986
66RPS6KL10.93878986
67MKNK10.91485342
68CAMKK10.89397185
69CDK50.86567295
70CASK0.85088386
71LMTK20.84298744
72ERBB20.83103160
73DYRK20.82735415
74PLK10.82272389
75MARK20.81923000
76FES0.81218101
77PLK20.81159964
78EPHB20.80076523
79PRKAA20.77978076
80RPS6KA20.77943974
81DYRK30.77507877
82RPS6KA60.75524828
83FGFR10.74283658
84CSNK1A1L0.73277567
85CDK150.72965691
86ROCK20.72026189
87MAPK150.71221168
88ERBB30.69299759
89TGFBR10.68964099
90CDK180.67884675
91NUAK10.67420575
92SGK2230.66880630
93SGK4940.66880630
94MAPK100.64878331
95CDK11A0.63267584
96CDK140.62908059
97FGFR20.61969898
98BMX0.60975472
99WNK40.60400398
100PAK30.60166156
101ADRBK20.59762434
102BCKDK0.57994239
103MAPK130.57507646
104PRKCG0.57241910
105EPHA30.56763178
106CSNK1G10.55551069
107CSNK1G30.55015755
108TRIM280.54947272
109CHEK20.54751554
110STK160.54083008
111PLK30.53996428
112PNCK0.53840692
113IGF1R0.53357970
114PLK40.53123450
115STK110.50557138
116GRK10.50108133
117CSNK1G20.49887599
118PHKG10.49858179
119PHKG20.49858179
120STK390.49510913
121CDK190.49064056
122CAMK2A0.47609826
123SRPK10.47452901
124MTOR0.47037858
125MAP3K20.46810919
126KSR10.45988247
127PIK3CA0.44701637
128WEE10.44579273
129BCR0.44357174
130PRKACG0.44325732
131BRD40.43613972
132SRC0.43313086
133GRK50.43046113
134CDK30.41883642
135ADRBK10.41245996
136TNK20.41124443
137FGR0.41075363
138PRKD10.38520214
139INSR0.37994350
140PRKCE0.37917862
141MAP2K40.37622658
142ERN10.37350643
143MAPK80.37265560
144NEK20.37189768
145SGK30.36879672
146RPS6KA40.36822880
147ATR0.36105482
148VRK10.36035745
149MAPK120.35266798
150MAPK90.35249606
151EIF2AK30.35228717
152BRAF0.34564999
153ZAP700.34395279
154ILK0.33981903
155RPS6KA30.33592581
156CSNK1E0.33558957
157FYN0.31782891
158DYRK1A0.31132762
159MOS0.27238102
160CSNK1A10.25159781
161PDPK10.24304361
162BRSK10.23066962
163PRKACA0.22903841
164PIK3CG0.22427599
165CSNK1D0.21915101
166AKT20.20665453
167MAP3K70.18952727
168AURKA0.18611278
169AURKB0.18425642
170OXSR10.16409887
171PRKCI0.16195341

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.19267028
2Phototransduction_Homo sapiens_hsa047443.79455307
3Arginine biosynthesis_Homo sapiens_hsa002203.71328374
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.91830472
5Nitrogen metabolism_Homo sapiens_hsa009102.60773235
6Sphingolipid metabolism_Homo sapiens_hsa006002.46272164
7Circadian entrainment_Homo sapiens_hsa047132.32042555
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.28220255
9Dorso-ventral axis formation_Homo sapiens_hsa043202.08772011
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08633205
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08311141
12Long-term depression_Homo sapiens_hsa047302.02980562
13Salivary secretion_Homo sapiens_hsa049701.96738493
14Renin secretion_Homo sapiens_hsa049241.96148597
15GABAergic synapse_Homo sapiens_hsa047271.87591648
16Fanconi anemia pathway_Homo sapiens_hsa034601.82022059
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.75308951
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.64850509
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64794477
20Basal cell carcinoma_Homo sapiens_hsa052171.60822726
21Notch signaling pathway_Homo sapiens_hsa043301.58208543
22Thyroid cancer_Homo sapiens_hsa052161.57388325
23Melanogenesis_Homo sapiens_hsa049161.57246468
24Bile secretion_Homo sapiens_hsa049761.54383598
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52025896
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51599076
27Hedgehog signaling pathway_Homo sapiens_hsa043401.49101635
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48095948
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47828605
30Axon guidance_Homo sapiens_hsa043601.47828109
31Glutamatergic synapse_Homo sapiens_hsa047241.43803904
32Steroid biosynthesis_Homo sapiens_hsa001001.43789525
33Insulin secretion_Homo sapiens_hsa049111.41904611
34Basal transcription factors_Homo sapiens_hsa030221.41253559
35Arginine and proline metabolism_Homo sapiens_hsa003301.39831490
36Synaptic vesicle cycle_Homo sapiens_hsa047211.37833120
37Morphine addiction_Homo sapiens_hsa050321.35913239
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.35771742
39Gap junction_Homo sapiens_hsa045401.32630855
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31284627
41Nicotine addiction_Homo sapiens_hsa050331.31167061
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26056028
43One carbon pool by folate_Homo sapiens_hsa006701.25700744
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.22837826
45Phenylalanine metabolism_Homo sapiens_hsa003601.22257554
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22232132
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20095107
48Gastric acid secretion_Homo sapiens_hsa049711.19475043
49Cocaine addiction_Homo sapiens_hsa050301.19226488
50Long-term potentiation_Homo sapiens_hsa047201.18795617
51Estrogen signaling pathway_Homo sapiens_hsa049151.18511563
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18062340
53Dopaminergic synapse_Homo sapiens_hsa047281.17725435
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15593819
55Type II diabetes mellitus_Homo sapiens_hsa049301.14261200
56N-Glycan biosynthesis_Homo sapiens_hsa005101.13491566
57Cholinergic synapse_Homo sapiens_hsa047251.12679925
58Hippo signaling pathway_Homo sapiens_hsa043901.12220226
59Glioma_Homo sapiens_hsa052141.09135447
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05617523
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05132221
62Amphetamine addiction_Homo sapiens_hsa050311.04230620
63MicroRNAs in cancer_Homo sapiens_hsa052061.03314326
64Tryptophan metabolism_Homo sapiens_hsa003801.01145387
65Propanoate metabolism_Homo sapiens_hsa006401.00691825
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97210293
67Cell cycle_Homo sapiens_hsa041100.96087848
68Renal cell carcinoma_Homo sapiens_hsa052110.95968335
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95564503
70Biosynthesis of amino acids_Homo sapiens_hsa012300.94895177
71Taste transduction_Homo sapiens_hsa047420.92923531
72Non-small cell lung cancer_Homo sapiens_hsa052230.92286625
73GnRH signaling pathway_Homo sapiens_hsa049120.91766889
74cAMP signaling pathway_Homo sapiens_hsa040240.91171493
75Homologous recombination_Homo sapiens_hsa034400.90984341
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87453123
77Butanoate metabolism_Homo sapiens_hsa006500.87410283
78Pyruvate metabolism_Homo sapiens_hsa006200.87390925
79Oxytocin signaling pathway_Homo sapiens_hsa049210.87088467
80Olfactory transduction_Homo sapiens_hsa047400.86052879
81Wnt signaling pathway_Homo sapiens_hsa043100.86046659
82mTOR signaling pathway_Homo sapiens_hsa041500.85348239
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84822374
84ErbB signaling pathway_Homo sapiens_hsa040120.84217994
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82579540
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82101637
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80673019
88Renin-angiotensin system_Homo sapiens_hsa046140.79998076
89Sulfur relay system_Homo sapiens_hsa041220.79091014
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.78908571
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78346194
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77166511
93Lysine degradation_Homo sapiens_hsa003100.77054079
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76476840
95Adherens junction_Homo sapiens_hsa045200.76264639
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.76137100
97Rap1 signaling pathway_Homo sapiens_hsa040150.76075526
98Protein export_Homo sapiens_hsa030600.76023575
99Colorectal cancer_Homo sapiens_hsa052100.75125077
100Serotonergic synapse_Homo sapiens_hsa047260.74834076
101Ovarian steroidogenesis_Homo sapiens_hsa049130.74102025
102Thyroid hormone synthesis_Homo sapiens_hsa049180.73825655
103Calcium signaling pathway_Homo sapiens_hsa040200.73509307
104Dilated cardiomyopathy_Homo sapiens_hsa054140.71969648
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71802641
106Fatty acid elongation_Homo sapiens_hsa000620.71588123
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69420142
108RNA degradation_Homo sapiens_hsa030180.69117935
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69080875
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68664144
111Linoleic acid metabolism_Homo sapiens_hsa005910.68580750
112Mismatch repair_Homo sapiens_hsa034300.68544242
113Proteoglycans in cancer_Homo sapiens_hsa052050.67917171
114Endometrial cancer_Homo sapiens_hsa052130.67477440
115Histidine metabolism_Homo sapiens_hsa003400.66637792
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.66359254
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64216177
118Vibrio cholerae infection_Homo sapiens_hsa051100.62585468
119Insulin signaling pathway_Homo sapiens_hsa049100.61421137
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60241318
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59939441
122beta-Alanine metabolism_Homo sapiens_hsa004100.59705971
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59398722
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59201287
125AMPK signaling pathway_Homo sapiens_hsa041520.58016295
126Peroxisome_Homo sapiens_hsa041460.57807876
127Prion diseases_Homo sapiens_hsa050200.57758658
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57240927
129Glucagon signaling pathway_Homo sapiens_hsa049220.56988492
130Bladder cancer_Homo sapiens_hsa052190.55854924
131TGF-beta signaling pathway_Homo sapiens_hsa043500.55807133
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54610487
133Fatty acid biosynthesis_Homo sapiens_hsa000610.53311420
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52867019
135Oocyte meiosis_Homo sapiens_hsa041140.51874103
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.50737066
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50697522
138Platelet activation_Homo sapiens_hsa046110.50336257
139Collecting duct acid secretion_Homo sapiens_hsa049660.49775589
140Fatty acid degradation_Homo sapiens_hsa000710.48723453
141Pancreatic secretion_Homo sapiens_hsa049720.48531734
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47978871
143Insulin resistance_Homo sapiens_hsa049310.47958926
144Non-homologous end-joining_Homo sapiens_hsa034500.46779811
145Selenocompound metabolism_Homo sapiens_hsa004500.46728341
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46513859
147Fructose and mannose metabolism_Homo sapiens_hsa000510.46019831
148Tight junction_Homo sapiens_hsa045300.44766216
149Ribosome_Homo sapiens_hsa030100.44727666
150Tyrosine metabolism_Homo sapiens_hsa003500.44496876
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44132997
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.43463263
153Pathways in cancer_Homo sapiens_hsa052000.43087192
154Fatty acid metabolism_Homo sapiens_hsa012120.42949723
155Folate biosynthesis_Homo sapiens_hsa007900.41298933
156Metabolic pathways_Homo sapiens_hsa011000.40834996
157DNA replication_Homo sapiens_hsa030300.36038455
158Glycerolipid metabolism_Homo sapiens_hsa005610.32499326
159Base excision repair_Homo sapiens_hsa034100.30356284

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