VAX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.04296263
2polyketide metabolic process (GO:0030638)8.04296263
3doxorubicin metabolic process (GO:0044598)8.04296263
4interferon-gamma production (GO:0032609)5.79034372
5maintenance of protein location in nucleus (GO:0051457)5.50992930
6regulation of chromatin binding (GO:0035561)4.93552459
7DNA unwinding involved in DNA replication (GO:0006268)4.91470452
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.80646555
9aminoglycoside antibiotic metabolic process (GO:0030647)4.78468666
10somite rostral/caudal axis specification (GO:0032525)4.76638415
11regulation of mammary gland epithelial cell proliferation (GO:0033599)4.40339016
12protein heterotetramerization (GO:0051290)4.39380895
13positive regulation of developmental pigmentation (GO:0048087)4.27392622
14retinal rod cell development (GO:0046548)4.10225592
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.08884344
16bone trabecula formation (GO:0060346)4.08843785
17negative regulation of telomere maintenance (GO:0032205)4.08641115
18negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.95557762
19cochlea morphogenesis (GO:0090103)3.93730962
20tachykinin receptor signaling pathway (GO:0007217)3.84031570
21lymph vessel development (GO:0001945)3.82350571
22regulation of MHC class I biosynthetic process (GO:0045343)3.76972054
23regulation of response to osmotic stress (GO:0047484)3.63906998
24intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.63330054
25positive regulation of DNA-dependent DNA replication (GO:2000105)3.62890254
26homeostasis of number of cells within a tissue (GO:0048873)3.60761694
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.59979458
28photoreceptor cell maintenance (GO:0045494)3.49765078
29negative regulation of cell cycle G2/M phase transition (GO:1902750)3.43890674
30primitive streak formation (GO:0090009)3.43639919
31regulation of telomere maintenance via telomerase (GO:0032210)3.43210792
32branching involved in mammary gland duct morphogenesis (GO:0060444)3.42260274
33gap junction assembly (GO:0016264)3.36849598
34axon extension involved in axon guidance (GO:0048846)3.32987056
35neuron projection extension involved in neuron projection guidance (GO:1902284)3.32987056
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.25484669
37regulation of rhodopsin mediated signaling pathway (GO:0022400)3.21683312
38receptor recycling (GO:0001881)3.21092803
39rhodopsin mediated signaling pathway (GO:0016056)3.20032300
40regulation of interleukin-2 biosynthetic process (GO:0045076)3.18040053
41T cell differentiation involved in immune response (GO:0002292)3.15456747
42alpha-beta T cell differentiation involved in immune response (GO:0002293)3.15456747
43alpha-beta T cell activation involved in immune response (GO:0002287)3.15456747
44ectodermal placode formation (GO:0060788)3.15420291
45protein retention in ER lumen (GO:0006621)3.15106750
46histone H4-K12 acetylation (GO:0043983)3.15057281
47negative regulation of telomerase activity (GO:0051974)3.11230479
48regulation of apoptotic process involved in morphogenesis (GO:1902337)3.07675765
49notochord development (GO:0030903)3.07044402
50body morphogenesis (GO:0010171)3.06964464
51histone H4-K5 acetylation (GO:0043981)3.06894456
52histone H4-K8 acetylation (GO:0043982)3.06894456
53retina layer formation (GO:0010842)3.05553468
54outflow tract septum morphogenesis (GO:0003148)3.03875455
55pattern specification involved in kidney development (GO:0061004)3.02877163
56eye photoreceptor cell development (GO:0042462)3.02754138
57nucleoside transmembrane transport (GO:1901642)3.02271474
58photoreceptor cell development (GO:0042461)2.96340127
59peptidyl-proline hydroxylation (GO:0019511)2.95730922
60negative regulation of epidermis development (GO:0045683)2.94185202
61rRNA transcription (GO:0009303)2.94143778
62maintenance of protein localization in organelle (GO:0072595)2.93754639
63postsynaptic membrane organization (GO:0001941)2.93017343
64female genitalia development (GO:0030540)2.92992484
65ganglion development (GO:0061548)2.92943159
66sequestering of actin monomers (GO:0042989)2.90591521
67regulation of telomere maintenance (GO:0032204)2.88054663
68peptidyl-arginine omega-N-methylation (GO:0035247)2.87478883
69barbed-end actin filament capping (GO:0051016)2.85118812
70mitotic sister chromatid segregation (GO:0000070)2.84907758
71negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.84115241
72detection of light stimulus involved in sensory perception (GO:0050962)2.83334249
73detection of light stimulus involved in visual perception (GO:0050908)2.83334249
744-hydroxyproline metabolic process (GO:0019471)2.83122019
75negative regulation of catenin import into nucleus (GO:0035414)2.82760640
76protein localization to kinetochore (GO:0034501)2.82728539
77regulation of cilium movement (GO:0003352)2.82557372
78activation of Rac GTPase activity (GO:0032863)2.81566224
79positive regulation of fat cell differentiation (GO:0045600)2.80899590
80muscle organ morphogenesis (GO:0048644)2.80738639
81cell proliferation involved in metanephros development (GO:0072203)2.80522300
82intracellular estrogen receptor signaling pathway (GO:0030520)2.80280681
83retinal cone cell development (GO:0046549)2.79827770
84embryonic skeletal joint morphogenesis (GO:0060272)2.79298931
85embryonic camera-type eye morphogenesis (GO:0048596)2.78009623
86muscle cell fate commitment (GO:0042693)2.77904081
87uterus development (GO:0060065)2.77357491
88negative regulation of cell size (GO:0045792)2.75994744
89establishment or maintenance of monopolar cell polarity (GO:0061339)2.75593756
90establishment of monopolar cell polarity (GO:0061162)2.75593756
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75471410
92positive regulation of digestive system process (GO:0060456)2.74884314
93convergent extension (GO:0060026)2.74330863
94positive regulation of protein homooligomerization (GO:0032464)2.72984491
95regulation of hippo signaling (GO:0035330)2.72319824
96Rap protein signal transduction (GO:0032486)2.71869605
97norepinephrine metabolic process (GO:0042415)2.71803636
98ncRNA 3-end processing (GO:0043628)2.70896993
99regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.69073033
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.68640184
101vagina development (GO:0060068)2.64727438
102transcription from mitochondrial promoter (GO:0006390)2.64253688
103positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63841897
104axon extension (GO:0048675)2.63831714
105CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.62550013
106T-helper cell differentiation (GO:0042093)2.62550013
107establishment of endothelial barrier (GO:0061028)2.60786931
108heterochromatin organization (GO:0070828)2.60689778
109regulation of double-strand break repair (GO:2000779)2.59616140
110semaphorin-plexin signaling pathway (GO:0071526)2.58533950
111embryonic body morphogenesis (GO:0010172)2.56800983
112kidney mesenchyme development (GO:0072074)2.55428973
113proximal/distal pattern formation (GO:0009954)2.54035325
114negative regulation of interleukin-2 production (GO:0032703)2.54022711
115negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.53686013
116intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.53395394
117striated muscle cell proliferation (GO:0014855)2.52970890
118cytidine deamination (GO:0009972)2.51902859
119cytidine metabolic process (GO:0046087)2.51902859
120cytidine catabolic process (GO:0006216)2.51902859
121chemosensory behavior (GO:0007635)2.49680696
122apoptotic process involved in morphogenesis (GO:0060561)2.49324009
123positive regulation of tissue remodeling (GO:0034105)2.48776886
124regulation of posttranscriptional gene silencing (GO:0060147)2.48681179
125regulation of gene silencing by miRNA (GO:0060964)2.48681179
126regulation of gene silencing by RNA (GO:0060966)2.48681179
127cellular senescence (GO:0090398)2.47256212
128Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47176680
129tooth mineralization (GO:0034505)2.46220743
130negative regulation of smoothened signaling pathway (GO:0045879)2.43760048
131organ induction (GO:0001759)2.43686727
132branching involved in labyrinthine layer morphogenesis (GO:0060670)2.42775136
133phototransduction, visible light (GO:0007603)2.41736769
134mitotic G1 DNA damage checkpoint (GO:0031571)2.39769314
135regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39746423
136vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39560804
137establishment of apical/basal cell polarity (GO:0035089)2.39314006
138cardiac muscle cell proliferation (GO:0060038)2.38772513
139phototransduction (GO:0007602)2.38245717
140detection of visible light (GO:0009584)2.38224103
141trivalent inorganic anion homeostasis (GO:0072506)2.38180739
142phosphate ion homeostasis (GO:0055062)2.38180739
143basement membrane organization (GO:0071711)2.37905493
144embryonic placenta development (GO:0001892)2.37826785
145rRNA methylation (GO:0031167)2.37592013
146* embryonic eye morphogenesis (GO:0048048)2.37384392
147regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.36244786
148developmental induction (GO:0031128)2.36200394
149regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35754129
150muscle cell proliferation (GO:0033002)2.35625434
151regulation of pigment cell differentiation (GO:0050932)2.35455370
152chromatin assembly (GO:0031497)2.34876226
153mammary gland epithelial cell differentiation (GO:0060644)2.34592342
154protein localization to chromosome, centromeric region (GO:0071459)2.33686664
155cell differentiation involved in embryonic placenta development (GO:0060706)2.33594950
156vitamin A metabolic process (GO:0006776)2.33309602
157execution phase of apoptosis (GO:0097194)2.33135739
158histone H3-K4 methylation (GO:0051568)2.32555703
159positive regulation of macrophage cytokine production (GO:0060907)2.31907671
160regulation of establishment of planar polarity (GO:0090175)2.31084321
161negative regulation of interleukin-12 production (GO:0032695)2.30508106
162negative regulation of keratinocyte proliferation (GO:0010839)2.30000963
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.29282869
164neuron fate commitment (GO:0048663)2.28864945
165detection of light stimulus (GO:0009583)2.28820492
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28697550
167protein hydroxylation (GO:0018126)2.27446512
168outer ear morphogenesis (GO:0042473)2.26847278
169calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.26816908
170apoptotic process involved in development (GO:1902742)2.26727676
171protein heterotrimerization (GO:0070208)2.25858554
172glial cell migration (GO:0008347)2.25593021
173histone arginine methylation (GO:0034969)2.25591127
174regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23844437
175cranial nerve morphogenesis (GO:0021602)2.23765411
176male sex determination (GO:0030238)2.22241134
177axonal fasciculation (GO:0007413)2.22086241
178sodium ion export (GO:0071436)2.20922363
179cell-cell signaling involved in cell fate commitment (GO:0045168)2.20866554
180regulation of G0 to G1 transition (GO:0070316)2.20610856
181hippo signaling (GO:0035329)2.18532409
182positive regulation of mesonephros development (GO:0061213)2.18492776
183positive regulation of synapse maturation (GO:0090129)2.18328024
184positive regulation of blood vessel endothelial cell migration (GO:0043536)2.18106975
185* eye morphogenesis (GO:0048592)2.17847507
186locomotory exploration behavior (GO:0035641)2.17393506
187negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.17162582
188mitochondrial fusion (GO:0008053)2.16450067
189peptidyl-arginine N-methylation (GO:0035246)2.16275161
190peptidyl-arginine methylation (GO:0018216)2.16275161
191embryonic skeletal system morphogenesis (GO:0048704)2.14944440
192mitotic chromosome condensation (GO:0007076)2.13637683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.91642556
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.63514673
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.63514673
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.63514673
5TP63_19390658_ChIP-ChIP_HaCaT_Human4.39231210
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09291851
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.99323571
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.20622284
9EZH2_22144423_ChIP-Seq_EOC_Human2.91536595
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.88168939
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.70079082
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.66895922
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.58134555
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.50394235
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.42012100
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.34626896
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34058163
18* LXR_22292898_ChIP-Seq_THP-1_Human2.24319488
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20840869
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.18103070
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02019224
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01193988
23RACK7_27058665_Chip-Seq_MCF-7_Human1.97530039
24NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.94742273
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93616028
26* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92355681
27* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92355681
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91027547
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88974587
30* EED_16625203_ChIP-ChIP_MESCs_Mouse1.88345663
31IRF1_19129219_ChIP-ChIP_H3396_Human1.85127974
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85040782
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.84987024
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84720834
35* EZH2_27304074_Chip-Seq_ESCs_Mouse1.84682965
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.83922674
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82520266
38* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80837799
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80100792
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78092361
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76467307
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.75286087
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74742814
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.73696829
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.73581613
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72112649
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.71801973
48POU5F1_16518401_ChIP-PET_MESCs_Mouse1.71057577
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70458060
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68902006
51* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67528920
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.65037229
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62599923
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60244408
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59425307
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55766257
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54454037
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.54080706
59OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53932029
60CTCF_27219007_Chip-Seq_Bcells_Human1.53495160
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52766693
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52146547
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51462356
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51433262
65* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49730125
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.48947146
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47482533
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.44754712
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44727233
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44577445
71XRN2_22483619_ChIP-Seq_HELA_Human1.43816827
72P68_20966046_ChIP-Seq_HELA_Human1.43376365
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43081126
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41100044
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.40957142
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40166155
77TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37075883
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36687816
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36306545
80* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35723722
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.35428471
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35390225
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35074615
84STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.34726670
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34546042
86TP53_22127205_ChIP-Seq_IMR90_Human1.33755703
87PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32911444
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32642094
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31893424
90KDM2B_26808549_Chip-Seq_DND41_Human1.31545369
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29955915
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29269532
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28876232
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.27328409
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26892386
96NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24615088
97SMC4_20622854_ChIP-Seq_HELA_Human1.22864782
98* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22843437
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22545217
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.22336619
101ZNF263_19887448_ChIP-Seq_K562_Human1.21753827
102* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21364203
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21318269
104* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21238262
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.19287441
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18826659
107* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18614832
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18308226
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17876624
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16568705
111* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16123106
112* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14493769
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.13785964
114NANOG_16518401_ChIP-PET_MESCs_Mouse1.13757443
115KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13569417
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12937995
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12866514
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.12809705
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12735600
120* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12352758
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11459512
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10934219
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.09540889
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09387904
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09352626
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07352262
127VDR_21846776_ChIP-Seq_THP-1_Human1.07089174
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07085567
129CREB1_26743006_Chip-Seq_LNCaP_Human1.06942272
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06933279
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06660202
132TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06473211
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06071517
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03158132
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02911707
136NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02461328
137NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01749762
138RNF2_27304074_Chip-Seq_NSC_Mouse1.00341896
139E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99697168
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99536556
141POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98843398
142HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98641751
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.98335901
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.98220438
145RUNX_20019798_ChIP-Seq_JUKART_Human0.98124447
146STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97774192
147MYC_22102868_ChIP-Seq_BL_Human0.96325561
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93297983
149KDM2B_26808549_Chip-Seq_K562_Human0.92321994
150SMAD_19615063_ChIP-ChIP_OVARY_Human0.92308295
151MYB_26560356_Chip-Seq_TH1_Human0.90322888
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86891430
153ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86092651
154* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85514286
155TP53_23651856_ChIP-Seq_MEFs_Mouse0.84333409
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83865065
157RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83350685
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81740705
159TCF7_22412390_ChIP-Seq_EML_Mouse0.81150686
160RNF2_27304074_Chip-Seq_ESCs_Mouse0.80161572
161E2F4_17652178_ChIP-ChIP_JURKAT_Human0.80004993
162RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79854580
163WDR5_24793694_ChIP-Seq_LNCAP_Human0.79523097
164PHF8_20622854_ChIP-Seq_HELA_Human0.79079742
165ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78385585
166POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77991362
167CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77433357
168E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76817614
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.76593600
170NANOG_16153702_ChIP-ChIP_HESCs_Human0.76058288
171SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75321558
172SOX2_18692474_ChIP-Seq_MESCs_Mouse0.75029299
173KAP1_27257070_Chip-Seq_ESCs_Mouse0.73091889
174STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73047438
175STAT1_20625510_ChIP-Seq_HELA_Human0.72756129
176SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72658164
177PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72602077
178RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72300259
179PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71981380
180IRF8_27001747_Chip-Seq_BMDM_Mouse0.71049538
181NCOR1_26117541_ChIP-Seq_K562_Human0.69197884
182TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.68597758
183PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67587472
184CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67412888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.68373948
2MP0003011_delayed_dark_adaptation4.50575914
3MP0003136_yellow_coat_color4.41554014
4MP0005075_abnormal_melanosome_morpholog3.43511498
5MP0005257_abnormal_intraocular_pressure3.12922348
6MP0002254_reproductive_system_inflammat2.98259525
7MP0003890_abnormal_embryonic-extraembry2.95472550
8MP0005551_abnormal_eye_electrophysiolog2.71401925
9MP0005379_endocrine/exocrine_gland_phen2.71267227
10MP0002277_abnormal_respiratory_mucosa2.69432165
11MP0004858_abnormal_nervous_system2.60623307
12MP0005253_abnormal_eye_physiology2.58192749
13MP0001346_abnormal_lacrimal_gland2.55824607
14MP0006072_abnormal_retinal_apoptosis2.47307848
15MP0005499_abnormal_olfactory_system2.45000284
16MP0005394_taste/olfaction_phenotype2.45000284
17MP0002160_abnormal_reproductive_system2.31981123
18MP0008057_abnormal_DNA_replication2.31870596
19MP0006082_CNS_inflammation2.27028870
20MP0001324_abnormal_eye_pigmentation2.26315889
21MP0002249_abnormal_larynx_morphology2.19150701
22MP0000003_abnormal_adipose_tissue2.12291761
23MP0002653_abnormal_ependyma_morphology2.09501429
24MP0004264_abnormal_extraembryonic_tissu2.08353381
25MP0003315_abnormal_perineum_morphology2.02418455
26MP0002822_catalepsy1.91787820
27MP0000534_abnormal_ureter_morphology1.84215153
28MP0001542_abnormal_bone_strength1.82316206
29MP0010368_abnormal_lymphatic_system1.81724732
30MP0003942_abnormal_urinary_system1.76734779
31MP0010030_abnormal_orbit_morphology1.76568508
32MP0002234_abnormal_pharynx_morphology1.76520626
33MP0003121_genomic_imprinting1.73922986
34MP0005391_vision/eye_phenotype1.69165677
35MP0005187_abnormal_penis_morphology1.66772807
36MP0003787_abnormal_imprinting1.63687655
37MP0002089_abnormal_postnatal_growth/wei1.57248613
38MP0008789_abnormal_olfactory_epithelium1.55716489
39MP0008438_abnormal_cutaneous_collagen1.52719178
40MP0000778_abnormal_nervous_system1.51527356
41MP0005503_abnormal_tendon_morphology1.50343577
42MP0009053_abnormal_anal_canal1.49021467
43MP0005197_abnormal_uvea_morphology1.47610179
44* MP0005195_abnormal_posterior_eye1.46466801
45MP0000678_abnormal_parathyroid_gland1.44611969
46MP0003122_maternal_imprinting1.43744614
47MP0005058_abnormal_lysosome_morphology1.43000056
48MP0005671_abnormal_response_to1.40823542
49MP0000685_abnormal_immune_system1.40243555
50MP0000049_abnormal_middle_ear1.38300426
51MP0002751_abnormal_autonomic_nervous1.34437680
52MP0003283_abnormal_digestive_organ1.34050445
53MP0003172_abnormal_lysosome_physiology1.32995869
54MP0002332_abnormal_exercise_endurance1.27777767
55MP0009250_abnormal_appendicular_skeleto1.27205788
56MP0001348_abnormal_lacrimal_gland1.25814245
57MP0003115_abnormal_respiratory_system1.25318578
58MP0001293_anophthalmia1.25101885
59MP0009379_abnormal_foot_pigmentation1.25060786
60MP0001849_ear_inflammation1.22515331
61* MP0002697_abnormal_eye_size1.21631303
62MP0000733_abnormal_muscle_development1.21503711
63MP0003880_abnormal_central_pattern1.20382645
64MP0005508_abnormal_skeleton_morphology1.20042949
65MP0004272_abnormal_basement_membrane1.19997694
66MP0000647_abnormal_sebaceous_gland1.19984524
67MP0002184_abnormal_innervation1.17042569
68MP0002163_abnormal_gland_morphology1.16778794
69MP0005171_absent_coat_pigmentation1.16205162
70MP0005387_immune_system_phenotype1.14361793
71MP0001790_abnormal_immune_system1.14361793
72MP0002396_abnormal_hematopoietic_system1.14175379
73MP0005645_abnormal_hypothalamus_physiol1.13821386
74MP0004133_heterotaxia1.11754614
75MP0002233_abnormal_nose_morphology1.10866810
76MP0002090_abnormal_vision1.10527560
77MP0000372_irregular_coat_pigmentation1.09300914
78MP0005389_reproductive_system_phenotype1.09166447
79MP0003123_paternal_imprinting1.08252925
80MP0002932_abnormal_joint_morphology1.07751329
81MP0002933_joint_inflammation1.06639267
82MP0003938_abnormal_ear_development1.05430849
83MP0003385_abnormal_body_wall1.05218726
84MP0008007_abnormal_cellular_replicative1.05143557
85MP0009785_altered_susceptibility_to1.04833739
86MP0005623_abnormal_meninges_morphology1.03789729
87MP0003755_abnormal_palate_morphology1.03573667
88MP0009384_cardiac_valve_regurgitation1.03564103
89MP0001800_abnormal_humoral_immune1.03472499
90MP0002736_abnormal_nociception_after1.02154508
91MP0005409_darkened_coat_color1.01952940
92MP0005248_abnormal_Harderian_gland1.01531126
93MP0003137_abnormal_impulse_conducting1.00915916
94MP0001835_abnormal_antigen_presentation1.00601036
95MP0008961_abnormal_basal_metabolism1.00141888
96MP0005000_abnormal_immune_tolerance0.99617229
97MP0002127_abnormal_cardiovascular_syste0.97642954
98MP0004381_abnormal_hair_follicle0.97107708
99MP0004782_abnormal_surfactant_physiolog0.94531946
100MP0003705_abnormal_hypodermis_morpholog0.94097867
101MP0003935_abnormal_craniofacial_develop0.93928041
102MP0005023_abnormal_wound_healing0.93804652
103MP0000858_altered_metastatic_potential0.93691140
104MP0000579_abnormal_nail_morphology0.92057452
105* MP0001286_abnormal_eye_development0.91139239
106MP0002098_abnormal_vibrissa_morphology0.90976687
107MP0000955_abnormal_spinal_cord0.90494145
108MP0000432_abnormal_head_morphology0.90475844
109MP0003436_decreased_susceptibility_to0.90305253
110MP0002092_abnormal_eye_morphology0.90133090
111MP0003448_altered_tumor_morphology0.90032806
112MP0001984_abnormal_olfaction0.89338890
113MP0002148_abnormal_hypersensitivity_rea0.88677623
114MP0005375_adipose_tissue_phenotype0.88042205
115MP0000163_abnormal_cartilage_morphology0.87768668
116MP0002114_abnormal_axial_skeleton0.87137714
117MP0003329_amyloid_beta_deposits0.86985328
118* MP0003861_abnormal_nervous_system0.86569186
119MP0003279_aneurysm0.86364783
120* MP0002752_abnormal_somatic_nervous0.86179752
121MP0002723_abnormal_immune_serum0.84858272
122MP0002452_abnormal_antigen_presenting0.83571627
123MP0002405_respiratory_system_inflammati0.83477707
124MP0003077_abnormal_cell_cycle0.83242638
125MP0004270_analgesia0.82861718
126MP0003045_fibrosis0.82483907
127MP0005390_skeleton_phenotype0.82302162
128MP0005193_abnormal_anterior_eye0.82214618
129MP0008932_abnormal_embryonic_tissue0.82142324
130MP0004233_abnormal_muscle_weight0.82117125
131MP0002909_abnormal_adrenal_gland0.81510799
132MP0001819_abnormal_immune_cell0.81234575
133MP0001270_distended_abdomen0.80293138
134MP0000490_abnormal_crypts_of0.80126733
135MP0009780_abnormal_chondrocyte_physiolo0.80007863
136MP0001340_abnormal_eyelid_morphology0.79947690
137MP0000371_diluted_coat_color0.77964002
138MP0002420_abnormal_adaptive_immunity0.77631643
139MP0000762_abnormal_tongue_morphology0.77243664
140MP0001502_abnormal_circadian_rhythm0.76974731
141MP0003786_premature_aging0.76591905
142MP0005310_abnormal_salivary_gland0.76200810
143MP0003763_abnormal_thymus_physiology0.76000801
144MP0002109_abnormal_limb_morphology0.75286068
145* MP0002882_abnormal_neuron_morphology0.75215827
146MP0003941_abnormal_skin_development0.75136076
147MP0004859_abnormal_synaptic_plasticity0.74214645
148MP0003634_abnormal_glial_cell0.73918062
149MP0000759_abnormal_skeletal_muscle0.73500937
150MP0002398_abnormal_bone_marrow0.73405468
151MP0009764_decreased_sensitivity_to0.73269007
152MP0005451_abnormal_body_composition0.73254444
153MP0000467_abnormal_esophagus_morphology0.72572898
154MP0001243_abnormal_dermal_layer0.71139834
155MP0002111_abnormal_tail_morphology0.70489873
156MP0000689_abnormal_spleen_morphology0.69999976
157MP0004142_abnormal_muscle_tone0.69943281
158MP0002116_abnormal_craniofacial_bone0.69569358
159MP0005646_abnormal_pituitary_gland0.68861588
160MP0005025_abnormal_response_to0.68503906
161MP0002269_muscular_atrophy0.67928821
162MP0000026_abnormal_inner_ear0.67842045
163MP0003937_abnormal_limbs/digits/tail_de0.67377318
164MP0000428_abnormal_craniofacial_morphol0.67263578
165MP0002177_abnormal_outer_ear0.67078966
166MP0003111_abnormal_nucleus_morphology0.66590127
167MP0002638_abnormal_pupillary_reflex0.65506195

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)6.20563457
2Congenital stationary night blindness (HP:0007642)5.72077958
3Bilateral microphthalmos (HP:0007633)4.29136697
4Concave nail (HP:0001598)3.96827667
5Severe visual impairment (HP:0001141)3.91297386
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76082576
7Hypoplasia of the fovea (HP:0007750)3.71038892
8Aplasia/Hypoplasia of the fovea (HP:0008060)3.71038892
9Hypochromic microcytic anemia (HP:0004840)3.60371474
10Increased IgM level (HP:0003496)3.56498907
11Orchitis (HP:0100796)3.46550900
12Horizontal nystagmus (HP:0000666)3.43778196
13Rib fusion (HP:0000902)3.42003501
14Protrusio acetabuli (HP:0003179)3.34983301
15Dyschromatopsia (HP:0007641)3.33577382
16Abnormal rod and cone electroretinograms (HP:0008323)3.28350183
17Hyperthyroidism (HP:0000836)3.20595551
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19081128
19Abnormality of the aortic arch (HP:0012303)3.18486035
20Bony spicule pigmentary retinopathy (HP:0007737)3.16298268
21Chromsome breakage (HP:0040012)3.16226431
22Myositis (HP:0100614)2.96546594
23Bifid tongue (HP:0010297)2.88567259
24Abnormality of the thoracic spine (HP:0100711)2.82550926
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.81179841
26Abnormality of the lower motor neuron (HP:0002366)2.76985431
27Abnormality of the anterior chamber (HP:0000593)2.76801653
28Aplasia/Hypoplasia of the macula (HP:0008059)2.76452103
29Combined immunodeficiency (HP:0005387)2.73582006
30Abnormality of the phalanges of the hallux (HP:0010057)2.70464369
31Abnormality of the fovea (HP:0000493)2.68145617
32Abnormal sex determination (HP:0012244)2.68136422
33Sex reversal (HP:0012245)2.68136422
34Retrobulbar optic neuritis (HP:0100654)2.68082684
35Optic neuritis (HP:0100653)2.68082684
36Hepatoblastoma (HP:0002884)2.62661064
37Upper limb amyotrophy (HP:0009129)2.60325018
38Distal upper limb amyotrophy (HP:0007149)2.60325018
39Hand muscle atrophy (HP:0009130)2.57248546
40Nephroblastoma (Wilms tumor) (HP:0002667)2.46681584
41Short humerus (HP:0005792)2.46030490
42Germ cell neoplasia (HP:0100728)2.45384198
43Pigmentary retinal degeneration (HP:0001146)2.44741458
44Anomalous pulmonary venous return (HP:0010772)2.44083838
45Premature skin wrinkling (HP:0100678)2.43253891
46Abnormality of the ileum (HP:0001549)2.43198774
47Thoracic kyphosis (HP:0002942)2.41221803
48Ankle contracture (HP:0006466)2.40531500
49Meckel diverticulum (HP:0002245)2.40104744
50Congenital glaucoma (HP:0001087)2.40073564
51Thin bony cortex (HP:0002753)2.37928263
52Aplasia/hypoplasia of the humerus (HP:0006507)2.37712774
53Cheilitis (HP:0100825)2.31200672
54Scotoma (HP:0000575)2.31092254
55Rectovaginal fistula (HP:0000143)2.30837193
56Rectal fistula (HP:0100590)2.30837193
57Decreased central vision (HP:0007663)2.29909663
58Congenital malformation of the right heart (HP:0011723)2.29556131
59Double outlet right ventricle (HP:0001719)2.29556131
60Intestinal fistula (HP:0100819)2.27043506
61Type I transferrin isoform profile (HP:0003642)2.26977499
62Embryonal renal neoplasm (HP:0011794)2.25352387
63Chorioretinal atrophy (HP:0000533)2.24609284
64Hyperacusis (HP:0010780)2.23818854
65Achilles tendon contracture (HP:0001771)2.22539741
66Abnormality of the intervertebral disk (HP:0005108)2.22343651
67Septo-optic dysplasia (HP:0100842)2.21314102
68Aplasia/Hypoplasia affecting the retina (HP:0008061)2.20359884
69Elevated erythrocyte sedimentation rate (HP:0003565)2.18458355
70Reduced antithrombin III activity (HP:0001976)2.16480982
71Abnormality of macular pigmentation (HP:0008002)2.14586924
72Febrile seizures (HP:0002373)2.13903729
73Ulnar bowing (HP:0003031)2.13901541
74Buphthalmos (HP:0000557)2.12538702
75Short 5th finger (HP:0009237)2.11736240
76Macular degeneration (HP:0000608)2.11386871
77Vertebral arch anomaly (HP:0008438)2.10142242
78Attenuation of retinal blood vessels (HP:0007843)2.08218997
79Spinal rigidity (HP:0003306)2.06493229
80Flat capital femoral epiphysis (HP:0003370)2.06484188
81Albinism (HP:0001022)2.05679462
82Stridor (HP:0010307)2.05523288
83Cervical subluxation (HP:0003308)2.05226928
84Obstructive sleep apnea (HP:0002870)2.05056829
85Abnormality of the umbilical cord (HP:0010881)2.04787709
86Abnormality of the Achilles tendon (HP:0005109)2.04337287
87Hyperparathyroidism (HP:0000843)2.04239738
88Absent epiphyses (HP:0010577)2.03595871
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03595871
90Abnormality of the fetal cardiovascular system (HP:0010948)2.03537914
91Abnormal umbilical cord blood vessels (HP:0011403)2.03537914
92Single umbilical artery (HP:0001195)2.03537914
93Photophobia (HP:0000613)2.03482903
94Shallow orbits (HP:0000586)2.02933569
95Abnormality of the pulmonary veins (HP:0011718)2.00614776
96Neonatal short-limb short stature (HP:0008921)2.00133648
97Tongue fasciculations (HP:0001308)1.99587474
98Abnormality of dentin (HP:0010299)1.99164726
99Truncus arteriosus (HP:0001660)1.98963622
100Abnormality of the tricuspid valve (HP:0001702)1.97619702
101Flat acetabular roof (HP:0003180)1.97344977
102Hypoparathyroidism (HP:0000829)1.96625002
103Testicular atrophy (HP:0000029)1.95775040
104Hypoventilation (HP:0002791)1.94640096
105Glossoptosis (HP:0000162)1.94599043
106Abolished electroretinogram (ERG) (HP:0000550)1.94555199
107Disproportionate tall stature (HP:0001519)1.94543769
108Hypoplasia of the uterus (HP:0000013)1.92715199
109Osteomalacia (HP:0002749)1.92461441
110Spinal muscular atrophy (HP:0007269)1.92199952
111Abnormal number of incisors (HP:0011064)1.90836438
112Premature rupture of membranes (HP:0001788)1.90756132
113Abnormality of the preputium (HP:0100587)1.90005963
114Turricephaly (HP:0000262)1.89142067
115Short middle phalanx of the 5th finger (HP:0004220)1.87588309
116Uterine leiomyosarcoma (HP:0002891)1.87131427
117Leiomyosarcoma (HP:0100243)1.87131427
118Shawl scrotum (HP:0000049)1.85871946
119Patellar dislocation (HP:0002999)1.85427041
120Absent frontal sinuses (HP:0002688)1.85285354
121Septate vagina (HP:0001153)1.83725035
122Mesomelia (HP:0003027)1.83159281
123Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.82697065
124Thin ribs (HP:0000883)1.82336033
125Hypoplasia of the iris (HP:0007676)1.81470915
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81457354
127Long toe (HP:0010511)1.80031942
128Absent hand (HP:0004050)1.79701969
129Hyperphosphatemia (HP:0002905)1.79583250
130Abnormality of molar (HP:0011077)1.79413675
131Abnormality of molar morphology (HP:0011070)1.79413675
132Asymmetry of the thorax (HP:0001555)1.78839500
133Abnormality of permanent molar morphology (HP:0011071)1.78713245
134Abnormality of the dental root (HP:0006486)1.78713245
135Taurodontia (HP:0000679)1.78713245
136Cardiovascular calcification (HP:0011915)1.78379598
137Abnormality of the duodenum (HP:0002246)1.78289241
138Axonal loss (HP:0003447)1.78260412
139Small intestinal stenosis (HP:0012848)1.78167027
140Duodenal stenosis (HP:0100867)1.78167027
141Coronal craniosynostosis (HP:0004440)1.78022980
142Hypochromic anemia (HP:0001931)1.77454902
143Ependymoma (HP:0002888)1.76944736
144Long palpebral fissure (HP:0000637)1.75925805
145Breech presentation (HP:0001623)1.74936628
146Generalized hypotonia (HP:0001290)1.74787177
147Upper limb muscle weakness (HP:0003484)1.74608758
148Preauricular skin tag (HP:0000384)1.74254466
149Abnormality of glycolipid metabolism (HP:0010969)1.72355513
150Abnormality of liposaccharide metabolism (HP:0010968)1.72355513
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.72355513
152Preauricular pit (HP:0004467)1.72163437
153Periauricular skin pits (HP:0100277)1.72163437
154Round ear (HP:0100830)1.71927510
155Elbow flexion contracture (HP:0002987)1.71295868
156Soft skin (HP:0000977)1.70943475
157Increased corneal curvature (HP:0100692)1.70514748
158Keratoconus (HP:0000563)1.70514748
159Cone-rod dystrophy (HP:0000548)1.70462521
160Abnormality of the acetabulum (HP:0003170)1.70069480
161Renal dysplasia (HP:0000110)1.70063079
162Broad distal phalanx of finger (HP:0009836)1.69683574
163Atelectasis (HP:0100750)1.69469009
164Lip pit (HP:0100267)1.68735646
165Muscle fibrillation (HP:0010546)1.68661598
166Vascular calcification (HP:0004934)1.68557306
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.68057029
168Volvulus (HP:0002580)1.67698432
169Fused cervical vertebrae (HP:0002949)1.66523281
170Abnormality of the astrocytes (HP:0100707)1.66402175
171Astrocytoma (HP:0009592)1.66402175
172Abnormality of the frontal sinuses (HP:0002687)1.65081479
173Anterior segment dysgenesis (HP:0007700)1.64080285
174Vertebral compression fractures (HP:0002953)1.63733990
175Vaginal fistula (HP:0004320)1.63642904
176Pseudobulbar signs (HP:0002200)1.63532486
177Microretrognathia (HP:0000308)1.63394321
178Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63122824
179Oligodontia (HP:0000677)1.62435730
180Capillary hemangiomas (HP:0005306)1.62215379
181Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62111908
182Duplication of thumb phalanx (HP:0009942)1.61112495
183Proximal placement of thumb (HP:0009623)1.60677014
184Prolonged neonatal jaundice (HP:0006579)1.58709888
185Hallux valgus (HP:0001822)1.56831978
186Mitral stenosis (HP:0001718)1.56228618
187Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54424747
188Ectopic kidney (HP:0000086)1.54236007
189Vitreoretinal degeneration (HP:0000655)1.54083080
190Subcapsular cataract (HP:0000523)1.53926254
191Deviation of the thumb (HP:0009603)1.53455563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.14281192
2TRIB33.90535706
3GRK53.82031052
4ADRBK23.74862996
5GRK13.43359036
6SMG13.19647344
7GRK62.83057207
8ERN12.63573277
9RIPK12.49463233
10PRKD32.44042949
11TGFBR22.42605985
12CSF1R2.32496294
13VRK22.27381168
14NME22.20433309
15GRK72.17519555
16SIK32.06893484
17PKN21.98404556
18TYRO31.98291450
19EPHA41.91491196
20EIF2AK21.76465269
21MATK1.65858283
22SIK21.56212820
23WNK11.53009417
24PRPF4B1.51250676
25EPHB21.50025276
26BRSK11.49447691
27ZAP701.49292870
28BLK1.45822351
29TXK1.45497790
30RPS6KA21.44225510
31MAP4K11.41791460
32ADRBK11.41538474
33KDR1.41336534
34YES11.36430059
35MAPK71.35931171
36AURKA1.35413215
37ARAF1.35267625
38CDK81.33939457
39AKT31.33375292
40IRAK31.33116877
41EPHA21.33112045
42MAP2K71.32476583
43MOS1.27720334
44SIK11.27463115
45PRKG21.26278586
46CDK71.25945258
47TTK1.25504259
48PRKD21.25196955
49MUSK1.22519846
50IKBKB1.21548679
51DYRK1B1.19352763
52CSK1.16575055
53ZAK1.15860007
54MAP3K141.14010900
55MTOR1.13470516
56ITK1.12983615
57STK101.11893700
58STK38L1.11376191
59HIPK21.09165584
60RPS6KC11.08068864
61RPS6KL11.08068864
62DDR21.07563947
63STK161.07541618
64CSNK1G31.04363756
65CHUK1.04340775
66EEF2K1.02311118
67MAP3K60.99483310
68AKT20.98726201
69CAMK40.98710688
70CSNK1A1L0.98229996
71CDK150.97904529
72ILK0.97334041
73MARK20.97314324
74STK240.97067688
75TAOK10.96177590
76CHEK20.95274830
77LIMK10.94129153
78CDK11A0.92222521
79CDK180.91406625
80MAPKAPK30.89823125
81ABL20.88687018
82MAP3K70.88487056
83TAOK20.87460174
84RPS6KA60.86375579
85WNK40.84851256
86BRAF0.84262429
87CASK0.83497060
88MARK10.83433665
89JAK30.82090584
90TTN0.81015159
91CDK140.79937966
92INSRR0.79510486
93BMX0.77473848
94NTRK30.77011116
95PAK40.76478963
96RPS6KB20.74978757
97AURKB0.73798805
98MAP2K60.73290756
99CSNK1E0.73135879
100STK380.72727787
101TESK20.72680212
102DAPK10.72222176
103MAP3K120.70816832
104MINK10.70688658
105PTK20.68170563
106SCYL20.65394345
107CSNK1G10.62307987
108ERBB30.59304548
109TAF10.59053004
110INSR0.58758817
111WEE10.57919432
112PRKCI0.57337933
113LCK0.56949755
114LATS20.55329610
115TNK20.54926359
116PTK60.54863254
117DYRK20.54056349
118MAP2K20.53637684
119CSNK1G20.52449030
120TESK10.52218712
121GSK3A0.51775126
122PIM20.51132343
123CDK30.50643952
124BMPR20.50156965
125ERBB20.49890904
126RET0.49725485
127CAMK2G0.49539807
128RPS6KA10.49418463
129PRKD10.49412038
130PDGFRB0.49132735
131PRKCD0.48824980
132VRK10.47862062
133PDGFRA0.47309272
134PRKDC0.46979390
135MAP2K40.46779525
136FGFR30.46030610
137UHMK10.45959412
138CAMK2B0.45824391
139CSNK1A10.44793766
140FGFR40.44022788
141PLK10.43658627
142IRAK20.43262178
143NTRK20.43017952
144PIM10.42607632
145STK30.42604933
146HCK0.42487169
147PRKAA10.42379097
148ATR0.41504312
149IGF1R0.41443722
150ICK0.41364089
151NEK20.41020083
152PDPK10.40411300
153LYN0.40381118
154SYK0.40256019
155PRKCZ0.39757201
156CHEK10.36317528
157MAP3K100.36201799
158CDC42BPA0.34291778
159JAK10.33796096
160BUB10.33385429
161CDK20.32180948
162MAPKAPK20.31908303
163NTRK10.31715337
164AKT10.31455765
165ATM0.31111153
166MARK30.30543781
167ALK0.29859273

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.35149085
2Phototransduction_Homo sapiens_hsa047443.98147628
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.86281418
4Graft-versus-host disease_Homo sapiens_hsa053323.07944661
5Vitamin B6 metabolism_Homo sapiens_hsa007502.18640037
6Hedgehog signaling pathway_Homo sapiens_hsa043402.10441701
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.09076738
8Fructose and mannose metabolism_Homo sapiens_hsa000511.93050278
9Allograft rejection_Homo sapiens_hsa053301.89898841
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.87236268
11Primary immunodeficiency_Homo sapiens_hsa053401.81689055
12Fanconi anemia pathway_Homo sapiens_hsa034601.76532033
13Basal cell carcinoma_Homo sapiens_hsa052171.73067025
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69782516
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.68789173
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68655031
17Ribosome_Homo sapiens_hsa030101.68476839
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65157021
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61971200
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61698328
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61567649
22Arginine and proline metabolism_Homo sapiens_hsa003301.60894070
23Hematopoietic cell lineage_Homo sapiens_hsa046401.60076194
24Arachidonic acid metabolism_Homo sapiens_hsa005901.59130286
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55623747
26Axon guidance_Homo sapiens_hsa043601.54174110
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50236913
28Vibrio cholerae infection_Homo sapiens_hsa051101.46989085
29Autoimmune thyroid disease_Homo sapiens_hsa053201.40127347
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35368475
31Measles_Homo sapiens_hsa051621.33766131
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31620691
33Bladder cancer_Homo sapiens_hsa052191.29416029
34Lysine degradation_Homo sapiens_hsa003101.23109685
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22497679
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21957368
37T cell receptor signaling pathway_Homo sapiens_hsa046601.18989373
38Herpes simplex infection_Homo sapiens_hsa051681.18746945
39Chronic myeloid leukemia_Homo sapiens_hsa052201.18392147
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15680832
41Leishmaniasis_Homo sapiens_hsa051401.15154781
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14491537
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09931206
44Homologous recombination_Homo sapiens_hsa034401.09836718
45Galactose metabolism_Homo sapiens_hsa000521.09292849
46Biosynthesis of amino acids_Homo sapiens_hsa012301.09235724
47Melanogenesis_Homo sapiens_hsa049161.08698173
48Folate biosynthesis_Homo sapiens_hsa007901.08463663
49Prion diseases_Homo sapiens_hsa050201.07574517
50ECM-receptor interaction_Homo sapiens_hsa045121.07000164
51Wnt signaling pathway_Homo sapiens_hsa043101.06994185
52Non-small cell lung cancer_Homo sapiens_hsa052231.04364781
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04139791
54Melanoma_Homo sapiens_hsa052181.04043784
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03391224
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02460066
57Glioma_Homo sapiens_hsa052141.00447874
58p53 signaling pathway_Homo sapiens_hsa041151.00243977
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.99442278
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98498044
61mTOR signaling pathway_Homo sapiens_hsa041500.98211272
62Focal adhesion_Homo sapiens_hsa045100.97492582
63One carbon pool by folate_Homo sapiens_hsa006700.97205005
64mRNA surveillance pathway_Homo sapiens_hsa030150.96571443
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.95787482
66Regulation of autophagy_Homo sapiens_hsa041400.94194300
67Dilated cardiomyopathy_Homo sapiens_hsa054140.92203386
68Apoptosis_Homo sapiens_hsa042100.92174103
69Malaria_Homo sapiens_hsa051440.91639793
70ErbB signaling pathway_Homo sapiens_hsa040120.91436767
71TNF signaling pathway_Homo sapiens_hsa046680.90860203
72Linoleic acid metabolism_Homo sapiens_hsa005910.90585169
73Insulin signaling pathway_Homo sapiens_hsa049100.90559011
74Legionellosis_Homo sapiens_hsa051340.90129121
75Type I diabetes mellitus_Homo sapiens_hsa049400.89765306
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89043600
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87710403
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87302936
79Inositol phosphate metabolism_Homo sapiens_hsa005620.84454415
80Hippo signaling pathway_Homo sapiens_hsa043900.83963152
81Fatty acid biosynthesis_Homo sapiens_hsa000610.83775002
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83614076
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82935991
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.82843934
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82203312
86Notch signaling pathway_Homo sapiens_hsa043300.81595270
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81245155
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80883942
89AMPK signaling pathway_Homo sapiens_hsa041520.80533057
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80446057
91Synaptic vesicle cycle_Homo sapiens_hsa047210.79894215
92DNA replication_Homo sapiens_hsa030300.78542531
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78446454
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78038806
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77746212
96Circadian rhythm_Homo sapiens_hsa047100.77538477
97Rap1 signaling pathway_Homo sapiens_hsa040150.76054606
98Acute myeloid leukemia_Homo sapiens_hsa052210.75580940
99Basal transcription factors_Homo sapiens_hsa030220.75400063
100Base excision repair_Homo sapiens_hsa034100.74709013
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74320141
102Pentose phosphate pathway_Homo sapiens_hsa000300.73481725
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73050113
104Ovarian steroidogenesis_Homo sapiens_hsa049130.72696449
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70933180
106MicroRNAs in cancer_Homo sapiens_hsa052060.70925318
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.70697932
108Osteoclast differentiation_Homo sapiens_hsa043800.70389629
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69801974
110Phenylalanine metabolism_Homo sapiens_hsa003600.68981428
111Viral myocarditis_Homo sapiens_hsa054160.68167524
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67916386
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67825512
114Staphylococcus aureus infection_Homo sapiens_hsa051500.67663262
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.67590787
116Sphingolipid metabolism_Homo sapiens_hsa006000.67250452
117Endometrial cancer_Homo sapiens_hsa052130.66831542
118Gap junction_Homo sapiens_hsa045400.66528398
119Chemokine signaling pathway_Homo sapiens_hsa040620.65633443
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65371026
121Other glycan degradation_Homo sapiens_hsa005110.64975544
122Rheumatoid arthritis_Homo sapiens_hsa053230.64196664
123Pathways in cancer_Homo sapiens_hsa052000.63575081
124Sulfur metabolism_Homo sapiens_hsa009200.62589172
125Influenza A_Homo sapiens_hsa051640.62138721
126Small cell lung cancer_Homo sapiens_hsa052220.62122374
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62007620
128Viral carcinogenesis_Homo sapiens_hsa052030.61805560
129Glycerolipid metabolism_Homo sapiens_hsa005610.61466546
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59280809
131HTLV-I infection_Homo sapiens_hsa051660.58500381
132Insulin secretion_Homo sapiens_hsa049110.58487603
133VEGF signaling pathway_Homo sapiens_hsa043700.58269019
134Taste transduction_Homo sapiens_hsa047420.57538647
135Cardiac muscle contraction_Homo sapiens_hsa042600.57203728
136Asthma_Homo sapiens_hsa053100.57118115
137Thyroid hormone synthesis_Homo sapiens_hsa049180.56010708
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.55953887
139Thyroid cancer_Homo sapiens_hsa052160.55472787
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55264584
141Serotonergic synapse_Homo sapiens_hsa047260.55015219
142Choline metabolism in cancer_Homo sapiens_hsa052310.54354197
143Ras signaling pathway_Homo sapiens_hsa040140.54180044
144Tight junction_Homo sapiens_hsa045300.53885417
145Tuberculosis_Homo sapiens_hsa051520.52094469
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.51769890
147Hepatitis B_Homo sapiens_hsa051610.51740833
148African trypanosomiasis_Homo sapiens_hsa051430.51508600
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50961944
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50724174
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50584818
152Pancreatic cancer_Homo sapiens_hsa052120.50194428
153Adherens junction_Homo sapiens_hsa045200.50156201
154Toxoplasmosis_Homo sapiens_hsa051450.50054984
155Cell cycle_Homo sapiens_hsa041100.47482874
156RNA degradation_Homo sapiens_hsa030180.47353358
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47182982
158Proteoglycans in cancer_Homo sapiens_hsa052050.47167067
159Prolactin signaling pathway_Homo sapiens_hsa049170.46572573
160Renal cell carcinoma_Homo sapiens_hsa052110.46143846
161Steroid biosynthesis_Homo sapiens_hsa001000.45763894
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45416386
163Estrogen signaling pathway_Homo sapiens_hsa049150.45009056
164Olfactory transduction_Homo sapiens_hsa047400.44904217
165Prostate cancer_Homo sapiens_hsa052150.44470948
166ABC transporters_Homo sapiens_hsa020100.44129487
167Colorectal cancer_Homo sapiens_hsa052100.43382401
168Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43338883
169Glutathione metabolism_Homo sapiens_hsa004800.42154114
170Glucagon signaling pathway_Homo sapiens_hsa049220.42123830
171Fatty acid metabolism_Homo sapiens_hsa012120.41638656
172GABAergic synapse_Homo sapiens_hsa047270.41158548
173Adipocytokine signaling pathway_Homo sapiens_hsa049200.39633161

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