VCAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.33391773
2lymphangiogenesis (GO:0001946)4.75911605
3vascular endothelial growth factor signaling pathway (GO:0038084)4.72120127
4positive regulation of protein kinase C signaling (GO:0090037)4.47083226
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.39385571
6endocardial cushion morphogenesis (GO:0003203)4.35322014
7protein heterotrimerization (GO:0070208)4.31942632
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.23756735
9positive regulation of astrocyte differentiation (GO:0048711)3.95555478
10negative regulation of protein localization to cell surface (GO:2000009)3.86349429
11dermatan sulfate biosynthetic process (GO:0030208)3.76257459
12interleukin-6-mediated signaling pathway (GO:0070102)3.75259280
13phenol-containing compound catabolic process (GO:0019336)3.60376321
14dermatan sulfate metabolic process (GO:0030205)3.58144130
15collagen fibril organization (GO:0030199)3.57376410
16vascular smooth muscle contraction (GO:0014829)3.53902929
17regulation of cardioblast differentiation (GO:0051890)3.48006387
18blood vessel maturation (GO:0001955)3.44867424
19negative regulation of hormone biosynthetic process (GO:0032353)3.42961018
20regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.40118891
21axon extension involved in axon guidance (GO:0048846)3.39156635
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.39156635
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36358764
24heart valve formation (GO:0003188)3.35300189
25* cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.34989063
26glial cell migration (GO:0008347)3.34457091
27glucocorticoid biosynthetic process (GO:0006704)3.34426975
28endothelium development (GO:0003158)3.33687105
29positive regulation of extracellular matrix organization (GO:1903055)3.31078597
30negative regulation of hormone metabolic process (GO:0032351)3.29720189
31cellular response to cholesterol (GO:0071397)3.26436753
32hormone catabolic process (GO:0042447)3.20670430
33response to follicle-stimulating hormone (GO:0032354)3.19128184
34positive regulation of cellular amide metabolic process (GO:0034250)3.17062294
35regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16431129
36response to lead ion (GO:0010288)3.12276265
37phagocytosis, recognition (GO:0006910)3.09808204
38complement activation, classical pathway (GO:0006958)3.09749208
39apoptotic cell clearance (GO:0043277)3.09280437
40epoxygenase P450 pathway (GO:0019373)3.08591178
41positive regulation vascular endothelial growth factor production (GO:0010575)3.04255887
42basement membrane organization (GO:0071711)3.04232645
43cardiac myofibril assembly (GO:0055003)3.03034972
44chondrocyte proliferation (GO:0035988)3.01608249
45omega-hydroxylase P450 pathway (GO:0097267)3.01577930
46growth hormone receptor signaling pathway (GO:0060396)3.01329146
47chondroitin sulfate biosynthetic process (GO:0030206)2.99925148
48regulation of endothelial cell differentiation (GO:0045601)2.98655168
49chondroitin sulfate catabolic process (GO:0030207)2.96070694
50positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.95933190
51negative regulation of platelet activation (GO:0010544)2.93692756
52cell adhesion mediated by integrin (GO:0033627)2.93279914
53regulation of vascular endothelial growth factor production (GO:0010574)2.92824894
54regulation of relaxation of muscle (GO:1901077)2.92014518
55opsonization (GO:0008228)2.91451809
56presynaptic membrane assembly (GO:0097105)2.90428675
57virion attachment to host cell (GO:0019062)2.89833631
58adhesion of symbiont to host cell (GO:0044650)2.89833631
59extracellular fibril organization (GO:0043206)2.89544836
60regulation of cardiac muscle cell contraction (GO:0086004)2.89456928
61sequestering of extracellular ligand from receptor (GO:0035581)2.88865746
62relaxation of cardiac muscle (GO:0055119)2.88775428
63regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88022155
64collagen metabolic process (GO:0032963)2.87727182
65complement activation (GO:0006956)2.87568166
66bone trabecula formation (GO:0060346)2.86061141
67otic vesicle formation (GO:0030916)2.83792780
68adhesion of symbiont to host (GO:0044406)2.83683538
69extracellular matrix assembly (GO:0085029)2.82817366
70negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.82773269
71cell communication by electrical coupling (GO:0010644)2.82543602
72complement activation, alternative pathway (GO:0006957)2.82409942
73positive regulation of endothelial cell differentiation (GO:0045603)2.81729069
74collagen catabolic process (GO:0030574)2.80982825
75endothelial cell morphogenesis (GO:0001886)2.80845191
76positive regulation of monocyte chemotaxis (GO:0090026)2.79395903
77cellular response to sterol (GO:0036315)2.78491962
78venous blood vessel morphogenesis (GO:0048845)2.78414346
79endothelial cell chemotaxis (GO:0035767)2.76907054
80cell proliferation involved in kidney development (GO:0072111)2.76615683
81regulation of axon extension involved in axon guidance (GO:0048841)2.76583317
82hyaluronan catabolic process (GO:0030214)2.76511702
83positive regulation of macrophage cytokine production (GO:0060907)2.76056801
84cellular response to interferon-alpha (GO:0035457)2.75150336
85radial glial cell differentiation (GO:0060019)2.73815195
86regulation of glucocorticoid metabolic process (GO:0031943)2.71732167
87oligodendrocyte differentiation (GO:0048709)2.71604798
88fibril organization (GO:0097435)2.69764148
89negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.69328978
90positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.68073830
91regulation of cellular extravasation (GO:0002691)2.67880467
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67446089
93heart valve morphogenesis (GO:0003179)2.66287891
94multicellular organismal macromolecule metabolic process (GO:0044259)2.65994827
95regulation of transforming growth factor beta2 production (GO:0032909)2.65987238
96regulation of the force of heart contraction (GO:0002026)2.65826284
97regulation of monocyte chemotaxis (GO:0090025)2.65663910
98cell migration involved in heart development (GO:0060973)2.64786575
99positive regulation of calcium ion import (GO:0090280)2.63505310
100cholesterol biosynthetic process (GO:0006695)2.63226338
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.62137208
102regulation of axon guidance (GO:1902667)2.60804758
103myofibril assembly (GO:0030239)2.59180345
104nephron tubule formation (GO:0072079)2.58996364
105cell proliferation involved in metanephros development (GO:0072203)2.58650487
106Notch signaling involved in heart development (GO:0061314)2.57916184
107substrate-dependent cell migration (GO:0006929)2.57650570
108skin morphogenesis (GO:0043589)2.57228449
109eye photoreceptor cell differentiation (GO:0001754)2.56765238
110photoreceptor cell differentiation (GO:0046530)2.56765238
111regulation of actin filament-based movement (GO:1903115)2.56573516
112positive regulation of natural killer cell differentiation (GO:0032825)2.55887871
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55778146
114endodermal cell differentiation (GO:0035987)2.54919393
115cellular response to growth hormone stimulus (GO:0071378)2.54035065
116sodium ion export (GO:0071436)2.53195626
117phenylpropanoid metabolic process (GO:0009698)2.52841083
118multicellular organismal catabolic process (GO:0044243)2.52287558
119positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52164405
120regulation of apoptotic cell clearance (GO:2000425)2.51553736
121antigen processing and presentation of endogenous antigen (GO:0019883)2.51068456
122smooth muscle tissue development (GO:0048745)2.50442696
123extracellular matrix disassembly (GO:0022617)2.50406343
124multicellular organismal metabolic process (GO:0044236)2.49805335
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48790428
126hyaluronan metabolic process (GO:0030212)2.48544753
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.47743564
128ganglion development (GO:0061548)2.47453389
129cGMP-mediated signaling (GO:0019934)2.47198103
130germ cell migration (GO:0008354)2.45718699
131negative regulation of chondrocyte differentiation (GO:0032331)2.45536413
132keratan sulfate catabolic process (GO:0042340)2.44519525
133limb bud formation (GO:0060174)2.44413364
134regulation of calcium ion import (GO:0090279)2.44036347
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43295251
136potassium ion import (GO:0010107)2.42826815
137glycosaminoglycan catabolic process (GO:0006027)2.42226443
138negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.41962772
139phospholipid homeostasis (GO:0055091)2.38793465
140mesenchyme morphogenesis (GO:0072132)2.38092182
141regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.37615749
142regulation of extracellular matrix organization (GO:1903053)2.37446268
143regulation of steroid hormone biosynthetic process (GO:0090030)2.37428895
144neuronal stem cell maintenance (GO:0097150)2.36925846
145negative regulation of blood vessel endothelial cell migration (GO:0043537)2.36861204
146G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.36745371
147negative regulation of leukocyte migration (GO:0002686)2.36243867
148endothelial cell migration (GO:0043542)2.35663690
149cellular response to gonadotropin stimulus (GO:0071371)2.34498951
150protein activation cascade (GO:0072376)2.34415177
151mesenchymal-epithelial cell signaling (GO:0060638)2.34005644
152positive regulation of osteoblast proliferation (GO:0033690)2.33788655
153positive regulation of smooth muscle cell migration (GO:0014911)2.33564565
154blood vessel endothelial cell migration (GO:0043534)2.33298092
155glomerular filtration (GO:0003094)2.32088861
156endothelial cell differentiation (GO:0045446)2.31853249
157regulation of platelet activation (GO:0010543)2.31844904
158reverse cholesterol transport (GO:0043691)2.31263146
159endothelial cell proliferation (GO:0001935)2.31169195
160substrate adhesion-dependent cell spreading (GO:0034446)2.30715165
161mesenchymal cell proliferation (GO:0010463)2.29270850
162* extracellular matrix organization (GO:0030198)2.29078096
163barbed-end actin filament capping (GO:0051016)2.28791563
164aminoglycan catabolic process (GO:0006026)2.28605606
165peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.28564711
166regulation of macrophage cytokine production (GO:0010935)2.28101822
167* extracellular structure organization (GO:0043062)2.28080977
168atrioventricular valve morphogenesis (GO:0003181)2.27469279
169negative chemotaxis (GO:0050919)2.26519000
170sterol biosynthetic process (GO:0016126)2.26493994
171regulation of mononuclear cell migration (GO:0071675)2.26261010
172atrial septum morphogenesis (GO:0060413)2.26056790
173regulation of protein activation cascade (GO:2000257)2.25717669
174low-density lipoprotein particle remodeling (GO:0034374)2.25690445
175phagocytosis, engulfment (GO:0006911)2.25319669
176retinal metabolic process (GO:0042574)2.24890938
177regulation of complement activation (GO:0030449)2.23806182
178negative regulation of oligodendrocyte differentiation (GO:0048715)2.23331939
179C4-dicarboxylate transport (GO:0015740)2.21951704
180cardiac chamber formation (GO:0003207)2.21896360
181thyroid hormone generation (GO:0006590)2.21878111
182toxin transport (GO:1901998)2.21460535
183negative regulation of astrocyte differentiation (GO:0048712)2.20833627
184glucocorticoid metabolic process (GO:0008211)2.20732411
185adrenal gland development (GO:0030325)2.19670420
186cellular sodium ion homeostasis (GO:0006883)2.18230979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.95284673
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.88481979
3CLOCK_20551151_ChIP-Seq_293T_Human2.79021782
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73218654
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.64832906
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61874467
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.58730514
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.51987267
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41182117
10EZH2_22144423_ChIP-Seq_EOC_Human2.27876516
11* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.23619970
12CJUN_26792858_Chip-Seq_BT549_Human2.19191369
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17354570
14* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12939914
15GATA1_22025678_ChIP-Seq_K562_Human2.11138987
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.07741380
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06214819
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.04035718
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.03126135
20IRF8_22096565_ChIP-ChIP_GC-B_Human1.91690022
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90107939
22* EP300_21415370_ChIP-Seq_HL-1_Mouse1.89484626
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89372200
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85110277
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83279112
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.81197874
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79618366
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79618366
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79372223
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74930704
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72504796
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70725220
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69244666
34* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68690456
35* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67944645
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.64287497
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62309642
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58969835
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58943498
40TP53_18474530_ChIP-ChIP_U2OS_Human1.58061776
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55454067
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55291347
43TAF15_26573619_Chip-Seq_HEK293_Human1.52408893
44P300_19829295_ChIP-Seq_ESCs_Human1.51964944
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51923088
46SMAD4_21799915_ChIP-Seq_A2780_Human1.51325492
47AR_21572438_ChIP-Seq_LNCaP_Human1.48876968
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48131511
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47631248
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.46702477
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45222611
52* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44212252
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44110676
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43985705
55* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42946834
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.42667694
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42179349
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41372333
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40199480
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.39844406
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.38733971
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38721585
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37942626
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.36747469
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34737356
66BRD4_25478319_ChIP-Seq_HGPS_Human1.34690511
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32586348
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32586348
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31323473
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.30987273
71SOX2_20726797_ChIP-Seq_SW620_Human1.29610273
72* VDR_24787735_ChIP-Seq_THP-1_Human1.28357372
73TP53_16413492_ChIP-PET_HCT116_Human1.26102409
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25577549
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25491265
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24800395
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24745863
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23926262
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22379857
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21757852
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.21693209
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.20632345
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19608071
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.19347778
85RXR_22108803_ChIP-Seq_LS180_Human1.18590838
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.18006998
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17737614
88* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16969074
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15794785
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15755326
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14323903
92HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14260708
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12228153
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12177781
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.11702098
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11457242
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11226305
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11214708
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.10519762
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.10346657
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09940945
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09940945
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09790972
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.09635703
105AR_25329375_ChIP-Seq_VCAP_Human1.09147721
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09132493
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.08475681
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07320276
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07053118
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07039287
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06587603
112BCAT_22108803_ChIP-Seq_LS180_Human1.06337707
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.06172134
114STAT3_23295773_ChIP-Seq_U87_Human1.05913513
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.05282841
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05062427
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02810035
118LXR_22158963_ChIP-Seq_LIVER_Mouse1.01025376
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00515000
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00162055
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00142374
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99387578
123* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99098151
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98969927
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98679786
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98675374
127DROSHA_22980978_ChIP-Seq_HELA_Human0.98564391
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98487746
129VDR_22108803_ChIP-Seq_LS180_Human0.98336065
130P53_22387025_ChIP-Seq_ESCs_Mouse0.98282750
131ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98144367
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.98017395
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.98017395
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97975419
135* SMAD3_21741376_ChIP-Seq_HESCs_Human0.97600775
136RUNX_20019798_ChIP-Seq_JUKART_Human0.97240137
137RXR_22158963_ChIP-Seq_LIVER_Mouse0.97157728
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96912869
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96807277
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96050838
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.95817996
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94997451
143* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94920679
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94427412
145* TCF4_22108803_ChIP-Seq_LS180_Human0.93500630
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.93212985
147GBX2_23144817_ChIP-Seq_PC3_Human0.92077924
148STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91989654
149TP63_23658742_ChIP-Seq_EP156T_Human0.91742704
150KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91690346
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90169612
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.88047089
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87586636
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.86921815
155JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86075692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.79789362
2MP0010368_abnormal_lymphatic_system4.76746572
3MP0006054_spinal_hemorrhage4.17587276
4MP0001879_abnormal_lymphatic_vessel4.05796654
5MP0005503_abnormal_tendon_morphology3.95568431
6MP0003136_yellow_coat_color3.70105453
7MP0003279_aneurysm3.69704181
8MP0003724_increased_susceptibility_to3.53602807
9MP0005275_abnormal_skin_tensile3.44208485
10MP0002254_reproductive_system_inflammat3.17018825
11MP0004272_abnormal_basement_membrane3.01114644
12MP0004084_abnormal_cardiac_muscle2.98550883
13MP0000566_synostosis2.49176286
14MP0001958_emphysema2.47652962
15MP0003011_delayed_dark_adaptation2.44728075
16MP0008004_abnormal_stomach_pH2.36698155
17MP0004145_abnormal_muscle_electrophysio2.32684699
18MP0008775_abnormal_heart_ventricle2.28974775
19MP0000462_abnormal_digestive_system2.25676559
20MP0003300_gastrointestinal_ulcer2.11715107
21MP0000013_abnormal_adipose_tissue2.04948478
22MP0003705_abnormal_hypodermis_morpholog1.96082569
23MP0009384_cardiac_valve_regurgitation1.92078155
24MP0000767_abnormal_smooth_muscle1.85550295
25MP0002295_abnormal_pulmonary_circulatio1.84354123
26MP0005248_abnormal_Harderian_gland1.82358110
27MP0005508_abnormal_skeleton_morphology1.80389024
28MP0003868_abnormal_feces_composition1.72394664
29MP0005187_abnormal_penis_morphology1.62350321
30MP0003329_amyloid_beta_deposits1.62120194
31MP0003566_abnormal_cell_adhesion1.61733694
32MP0004036_abnormal_muscle_relaxation1.61538656
33MP0005058_abnormal_lysosome_morphology1.56569735
34MP0000751_myopathy1.50212888
35MP0005257_abnormal_intraocular_pressure1.48935382
36MP0003091_abnormal_cell_migration1.46836444
37MP0004858_abnormal_nervous_system1.45169603
38MP0003828_pulmonary_edema1.45103805
39MP0002933_joint_inflammation1.45022960
40MP0002060_abnormal_skin_morphology1.44499610
41MP0003385_abnormal_body_wall1.43187387
42MP0000639_abnormal_adrenal_gland1.41414735
43MP0005023_abnormal_wound_healing1.41260339
44MP0005164_abnormal_response_to1.40992768
45MP0000343_altered_response_to1.38624912
46MP0001533_abnormal_skeleton_physiology1.37428735
47MP0005390_skeleton_phenotype1.35806750
48MP0005085_abnormal_gallbladder_physiolo1.32013102
49MP0005595_abnormal_vascular_smooth1.31997313
50MP0000537_abnormal_urethra_morphology1.31698361
51MP0004147_increased_porphyrin_level1.31081572
52MP0005330_cardiomyopathy1.29406859
53MP0001542_abnormal_bone_strength1.28584037
54MP0001851_eye_inflammation1.27233739
55MP0003950_abnormal_plasma_membrane1.27024869
56MP0005623_abnormal_meninges_morphology1.26903206
57MP0001835_abnormal_antigen_presentation1.25726183
58MP0001243_abnormal_dermal_layer1.25310119
59MP0000538_abnormal_urinary_bladder1.22336802
60MP0001984_abnormal_olfaction1.21374318
61MP0009840_abnormal_foam_cell1.20924527
62MP0009250_abnormal_appendicular_skeleto1.20109896
63MP0000604_amyloidosis1.18864768
64MP0004883_abnormal_blood_vessel1.18638748
65MP0002998_abnormal_bone_remodeling1.17841350
66MP0005620_abnormal_muscle_contractility1.16845256
67MP0000685_abnormal_immune_system1.13793036
68MP0003690_abnormal_glial_cell1.13779093
69MP0003303_peritoneal_inflammation1.13774572
70MP0000733_abnormal_muscle_development1.12391156
71MP0010329_abnormal_lipoprotein_level1.11261137
72MP0009764_decreased_sensitivity_to1.10396827
73MP0002233_abnormal_nose_morphology1.09881554
74MP0002638_abnormal_pupillary_reflex1.09740326
75MP0002128_abnormal_blood_circulation1.08123817
76MP0005253_abnormal_eye_physiology1.07656411
77MP0002148_abnormal_hypersensitivity_rea1.07209960
78MP0001177_atelectasis1.05812164
79MP0003075_altered_response_to1.05016017
80MP0002108_abnormal_muscle_morphology1.03779213
81MP0002419_abnormal_innate_immunity1.03396151
82MP0004085_abnormal_heartbeat1.02445916
83MP0002896_abnormal_bone_mineralization1.02344098
84MP0005165_increased_susceptibility_to1.02047367
85MP0000249_abnormal_blood_vessel1.01422065
86MP0010030_abnormal_orbit_morphology1.01193300
87MP0001661_extended_life_span0.99782789
88MP0001915_intracranial_hemorrhage0.99272551
89MP0003137_abnormal_impulse_conducting0.98854200
90MP0002133_abnormal_respiratory_system0.98798688
91MP0005388_respiratory_system_phenotype0.98798688
92MP0004510_myositis0.97956871
93MP0000465_gastrointestinal_hemorrhage0.95745763
94MP0005167_abnormal_blood-brain_barrier0.95215898
95MP0000383_abnormal_hair_follicle0.94942354
96MP0002282_abnormal_trachea_morphology0.93542911
97MP0000647_abnormal_sebaceous_gland0.92757241
98MP0004215_abnormal_myocardial_fiber0.92404760
99MP0003045_fibrosis0.91483700
100MP0003448_altered_tumor_morphology0.91383232
101MP0001873_stomach_inflammation0.90324540
102MP0000778_abnormal_nervous_system0.89700586
103MP0002932_abnormal_joint_morphology0.89148456
104MP0001614_abnormal_blood_vessel0.89111723
105MP0005397_hematopoietic_system_phenotyp0.88954773
106MP0001545_abnormal_hematopoietic_system0.88954773
107MP0001853_heart_inflammation0.88597237
108MP0005171_absent_coat_pigmentation0.88371879
109MP0010386_abnormal_urinary_bladder0.87745623
110MP0004782_abnormal_surfactant_physiolog0.86803090
111MP0000749_muscle_degeneration0.86344957
112MP0005670_abnormal_white_adipose0.86149793
113MP0000049_abnormal_middle_ear0.86099895
114MP0003115_abnormal_respiratory_system0.85955031
115MP0002249_abnormal_larynx_morphology0.85604142
116MP0003634_abnormal_glial_cell0.84921801
117MP0005551_abnormal_eye_electrophysiolog0.83579528
118MP0003632_abnormal_nervous_system0.83076676
119MP0005365_abnormal_bile_salt0.82999771
120MP0002166_altered_tumor_susceptibility0.82730008
121MP0001544_abnormal_cardiovascular_syste0.82527157
122MP0005385_cardiovascular_system_phenoty0.82527157
123MP0004484_altered_response_of0.82390020
124MP0000750_abnormal_muscle_regeneration0.82030021
125MP0000747_muscle_weakness0.81783864
126MP0001175_abnormal_lung_morphology0.81762320
127* MP0002127_abnormal_cardiovascular_syste0.81756543
128MP0000003_abnormal_adipose_tissue0.81451331
129MP0002115_abnormal_skeleton_extremities0.79427631
130MP0001790_abnormal_immune_system0.77676120
131MP0005387_immune_system_phenotype0.77676120
132MP0003795_abnormal_bone_structure0.77226980
133MP0000762_abnormal_tongue_morphology0.76907824
134MP0006276_abnormal_autonomic_nervous0.76727730
135MP0002138_abnormal_hepatobiliary_system0.76085579
136MP0002090_abnormal_vision0.75881916
137MP0001346_abnormal_lacrimal_gland0.75305032
138MP0005584_abnormal_enzyme/coenzyme_acti0.74995503
139MP0002113_abnormal_skeleton_development0.74640806
140MP0009278_abnormal_bone_marrow0.73893919
141MP0000163_abnormal_cartilage_morphology0.71646624
142MP0003755_abnormal_palate_morphology0.71201633
143MP0010630_abnormal_cardiac_muscle0.71173149
144MP0000428_abnormal_craniofacial_morphol0.69087430
145MP0000858_altered_metastatic_potential0.68879807
146MP0002925_abnormal_cardiovascular_devel0.68676107
147MP0006138_congestive_heart_failure0.67527570
148MP0002168_other_aberrant_phenotype0.66704135
149MP0002332_abnormal_exercise_endurance0.65432241
150MP0000534_abnormal_ureter_morphology0.65191348
151MP0005197_abnormal_uvea_morphology0.64673104
152MP0009785_altered_susceptibility_to0.61258737
153MP0003942_abnormal_urinary_system0.59702650
154MP0001299_abnormal_eye_distance/0.57978125
155MP0002972_abnormal_cardiac_muscle0.57560994
156MP0002405_respiratory_system_inflammati0.56925488
157MP0002006_tumorigenesis0.55318192

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.78588924
2Premature rupture of membranes (HP:0001788)5.32380474
3Broad metatarsal (HP:0001783)5.18293298
4Nonimmune hydrops fetalis (HP:0001790)4.84629097
5Complement deficiency (HP:0004431)4.56325573
6Follicular hyperkeratosis (HP:0007502)4.36966399
7Aortic dissection (HP:0002647)4.28352905
8Aortic aneurysm (HP:0004942)4.16430250
9Cerebral aneurysm (HP:0004944)4.04934226
10Short hallux (HP:0010109)4.02824432
11Soft skin (HP:0000977)3.87169453
12Aplasia/Hypoplasia of the hallux (HP:0008362)3.78466963
13Abnormality of complement system (HP:0005339)3.77367636
14Bladder diverticulum (HP:0000015)3.66503761
15Vitreoretinal degeneration (HP:0000655)3.66084504
16Ankle contracture (HP:0006466)3.65139151
17Vascular tortuosity (HP:0004948)3.59651604
18Shallow orbits (HP:0000586)3.56848961
19Limited hip movement (HP:0008800)3.31383395
20Vertebral compression fractures (HP:0002953)3.30659054
21Atrophic scars (HP:0001075)3.15333064
22Dilatation of the ascending aorta (HP:0005111)3.14142682
23Peritonitis (HP:0002586)3.08283034
24Biconcave vertebral bodies (HP:0004586)3.08189692
25Arterial tortuosity (HP:0005116)3.06731217
26Abnormality of the calf musculature (HP:0001430)2.95552035
27Ventricular tachycardia (HP:0004756)2.93169129
28Hip contracture (HP:0003273)2.93131827
29Hematochezia (HP:0002573)2.91311719
30Cervical subluxation (HP:0003308)2.89234028
31Neonatal short-limb short stature (HP:0008921)2.86988468
32Glomerulonephritis (HP:0000099)2.82196694
33Wormian bones (HP:0002645)2.73851097
34Abnormality of dentin (HP:0010299)2.71189647
35Increased corneal curvature (HP:0100692)2.62941256
36Keratoconus (HP:0000563)2.62941256
37Blue sclerae (HP:0000592)2.56915979
38Abnormality of the phalanges of the 2nd finger (HP:0009541)2.55863052
39Osteolytic defects of the hand bones (HP:0009699)2.53457990
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.53457990
41Mitral valve prolapse (HP:0001634)2.53020052
42Vertebral clefting (HP:0008428)2.51696108
43Mitral stenosis (HP:0001718)2.50828498
44Right ventricular cardiomyopathy (HP:0011663)2.49196219
45Abnormality of the diencephalon (HP:0010662)2.48806855
46Coronal craniosynostosis (HP:0004440)2.48071368
47Sensorimotor neuropathy (HP:0007141)2.47135940
48Myocardial infarction (HP:0001658)2.42465377
49Aplasia involving bones of the extremities (HP:0009825)2.42237773
50Aplasia involving bones of the upper limbs (HP:0009823)2.42237773
51Aplasia of the phalanges of the hand (HP:0009802)2.42237773
52Patent foramen ovale (HP:0001655)2.39189226
53Visceral angiomatosis (HP:0100761)2.38485608
54Partial duplication of thumb phalanx (HP:0009944)2.38178221
55Aneurysm (HP:0002617)2.37549350
56Fragile skin (HP:0001030)2.37544550
57Metaphyseal cupping (HP:0003021)2.37108927
58Cardiovascular calcification (HP:0011915)2.32956384
59Split foot (HP:0001839)2.32312786
60Dysostosis multiplex (HP:0000943)2.29875581
61Bronchomalacia (HP:0002780)2.29761664
62Polyphagia (HP:0002591)2.28669845
63Metaphyseal dysplasia (HP:0100255)2.27491636
64Asymmetry of the thorax (HP:0001555)2.26863685
65Vertebral hypoplasia (HP:0008417)2.24538293
66Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.24538293
67Spondylolisthesis (HP:0003302)2.24434349
68Spinal rigidity (HP:0003306)2.22251202
69Overgrowth (HP:0001548)2.22194712
70Pulmonary artery stenosis (HP:0004415)2.18858590
71Hypoalphalipoproteinemia (HP:0003233)2.18016793
72Alopecia of scalp (HP:0002293)2.16528972
73Turricephaly (HP:0000262)2.16452894
74Broad ribs (HP:0000885)2.15444791
75Spontaneous hematomas (HP:0007420)2.15363312
76Hemangiomatosis (HP:0007461)2.14980945
77Sudden death (HP:0001699)2.14767022
78Spinal cord lesions (HP:0100561)2.14470874
79Syringomyelia (HP:0003396)2.14470874
80Broad hallux (HP:0010055)2.14359897
81Absent toe (HP:0010760)2.12218802
82Venous abnormality (HP:0002624)2.11443169
83Hyperextensible skin (HP:0000974)2.10504536
84Venous insufficiency (HP:0005293)2.09612095
85Abnormality of the middle phalanges of the toes (HP:0010183)2.06698241
86Wrist flexion contracture (HP:0001239)2.06402095
87Partial duplication of the phalanx of hand (HP:0009999)2.04206784
88Chorioretinal atrophy (HP:0000533)2.03970149
89Broad toe (HP:0001837)2.03934471
90Type 1 muscle fiber predominance (HP:0003803)2.03126949
91Increased connective tissue (HP:0009025)2.03020612
92Genital tract atresia (HP:0001827)2.02696813
93Knee flexion contracture (HP:0006380)2.02434889
94Intrahepatic cholestasis (HP:0001406)2.00393306
95Hemiplegia (HP:0002301)1.99661475
96Atrial fibrillation (HP:0005110)1.99309820
97Short 4th metacarpal (HP:0010044)1.98975553
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98975553
99Vaginal atresia (HP:0000148)1.98696877
100Mitral regurgitation (HP:0001653)1.98673009
101Short tibia (HP:0005736)1.97257187
102Ectopia lentis (HP:0001083)1.97076111
103Systemic lupus erythematosus (HP:0002725)1.96974260
104Hemiparesis (HP:0001269)1.96566067
105Buphthalmos (HP:0000557)1.96432788
106Lymphangioma (HP:0100764)1.96392854
107Aortic valve stenosis (HP:0001650)1.96019652
108Craniofacial hyperostosis (HP:0004493)1.94592601
109Preaxial foot polydactyly (HP:0001841)1.93785606
110Megalencephaly (HP:0001355)1.93664698
111Infantile muscular hypotonia (HP:0008947)1.93350875
112Rectal prolapse (HP:0002035)1.91516373
113Genu recurvatum (HP:0002816)1.91390106
114Neurofibrillary tangles (HP:0002185)1.90842933
115Ileus (HP:0002595)1.90812639
116Abnormality of incisor morphology (HP:0011063)1.90721423
117Abnormality of the peritoneum (HP:0002585)1.90380922
118Tarsal synostosis (HP:0008368)1.88819583
119Joint laxity (HP:0001388)1.88558192
120Aortic regurgitation (HP:0001659)1.86377745
121Nephritis (HP:0000123)1.86098622
122Conjunctival telangiectasia (HP:0000524)1.85846954
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85783463
124Hypoplastic ischia (HP:0003175)1.85668586
125Camptodactyly of toe (HP:0001836)1.85262054
126Abnormality of skull ossification (HP:0002703)1.85010510
127Bell-shaped thorax (HP:0001591)1.83929678
128Absent frontal sinuses (HP:0002688)1.83818000
129Lipoatrophy (HP:0100578)1.83770849
130Polycythemia (HP:0001901)1.82923227
131Cutaneous finger syndactyly (HP:0010554)1.82719478
132Ovoid vertebral bodies (HP:0003300)1.82295806
133Hydroxyprolinuria (HP:0003080)1.82022494
134Abnormality of proline metabolism (HP:0010907)1.82022494
135Gingival overgrowth (HP:0000212)1.79991257
136Chondrocalcinosis (HP:0000934)1.79979945
137Alacrima (HP:0000522)1.79575399
138Short middle phalanx of the 5th finger (HP:0004220)1.79488140
139Hypoplasia of the iris (HP:0007676)1.77016516
140Tetraparesis (HP:0002273)1.77013987
141Epidermoid cyst (HP:0200040)1.76164965
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.75927240
143Short nail (HP:0001799)1.75724973
144Abnormality of the ischium (HP:0003174)1.74823284
145Asymmetric septal hypertrophy (HP:0001670)1.74329317
146Aplasia/Hypoplasia of the lens (HP:0008063)1.73386701
147Fibular hypoplasia (HP:0003038)1.73243027
148Mesomelia (HP:0003027)1.73128347
149Vascular calcification (HP:0004934)1.72330847
150Abnormality of Sharpey fibers (HP:0100685)1.72126132
151Capillary hemangiomas (HP:0005306)1.71953158
152Striae distensae (HP:0001065)1.71943285
153Thin ribs (HP:0000883)1.71633953
154Wide anterior fontanel (HP:0000260)1.70705194
155Left ventricular hypertrophy (HP:0001712)1.70248812
156Joint stiffness (HP:0001387)1.69784806
157Ulnar bowing (HP:0003031)1.69067565
158Diaphragmatic weakness (HP:0009113)1.68819148
159Facial shape deformation (HP:0011334)1.67581015
160Potter facies (HP:0002009)1.67581015
161Primary atrial arrhythmia (HP:0001692)1.65413169
162Congenital primary aphakia (HP:0007707)1.64202115
163Trigonocephaly (HP:0000243)1.63268872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.16503810
2TIE14.89708922
3TGFBR24.17201152
4PKN23.90171076
5OBSCN3.10265865
6PNCK3.05633568
7FLT32.88920370
8CASK2.59314889
9JAK12.36255858
10EPHA32.30502071
11EPHA42.28097420
12MAP3K142.13593817
13FGFR42.11191344
14TNIK2.05191808
15ERN12.03961708
16TTN1.98563621
17DDR21.97448513
18PTK2B1.96768090
19EPHB11.90349318
20STK38L1.86449810
21JAK31.78730683
22PDGFRA1.66092539
23BMX1.63876709
24EPHB21.61679632
25TYK21.57966791
26PTK61.57424878
27MYLK1.49491412
28TGFBR11.42932479
29SIK11.41542945
30CAMK1G1.40102967
31MET1.38556598
32NTRK21.38052706
33LMTK21.30868449
34STK391.30812074
35NTRK11.30509113
36FGFR31.30117803
37FRK1.28973850
38MOS1.23459480
39BMPR1B1.20098819
40BCR1.17944457
41TBK11.17254969
42KIT1.14004172
43FER1.11401692
44DMPK1.09966232
45TRIB31.08473620
46RIPK11.06460825
47ERBB31.06326244
48ROCK11.06285430
49PTK21.03941921
50MKNK21.01536752
51PAK21.01122817
52CAMK1D1.00797953
53TRPM70.99266663
54JAK20.91932042
55CSF1R0.91903790
56STK100.90926920
57LATS10.89725200
58CLK10.89402693
59NEK90.88885232
60CAMK40.83794600
61IKBKB0.81500573
62NTRK30.79627759
63CHUK0.78876658
64FGR0.77826855
65IKBKE0.76150539
66PDGFRB0.75525187
67PINK10.73617039
68EIF2AK20.73368490
69NUAK10.72886366
70RPS6KA40.71206882
71CSK0.69690756
72PAK30.68035742
73GRK10.65611990
74INSR0.65234261
75CDC42BPA0.65011290
76MAPKAPK30.64608104
77IRAK10.64596660
78IGF1R0.64393257
79CDK90.64178565
80CAMK2D0.63724423
81PAK40.63599836
82PIK3CA0.62847892
83PAK60.62741196
84MUSK0.61116609
85ERBB20.60789865
86PRKD10.60300066
87CSNK1G10.60041414
88RET0.59565945
89LRRK20.58062953
90CAMK2G0.56714862
91MAP3K20.56421489
92TSSK60.56172341
93MAP2K10.56050631
94STK30.55082889
95GRK70.54057509
96MAPK70.53966680
97ADRBK10.53739388
98FGFR20.52926334
99PRKG20.52566019
100ZAK0.52405681
101DYRK30.52404608
102BCKDK0.52395480
103SGK20.51263049
104KSR10.50389933
105EGFR0.50302819
106SRC0.50265450
107MAP3K60.47650052
108MAPK120.47496093
109MAPK150.47382451
110PRKCE0.47199941
111CAMK2A0.46805541
112MAP3K100.45347342
113PRKACG0.45121386
114MKNK10.44185701
115CSNK1A1L0.43953903
116PRKAA20.43902247
117NLK0.43870698
118CSNK1G20.42544486
119PLK20.42071991
120PHKG10.41081407
121PHKG20.41081407
122PKN10.39316700
123PIK3CG0.39277575
124WNK30.38829811
125PRKD30.38086415
126PRKCH0.37429634
127PRKG10.37273248
128FGFR10.37008484
129WEE10.36560803
130BMPR20.36352570
131IRAK30.36229074
132LYN0.36172024
133ILK0.35735350
134STK380.34153598
135PDK20.33358835
136MAPKAPK20.31942010
137YES10.31896655
138INSRR0.31578630
139ROCK20.31546191
140RAF10.31532692
141SGK2230.31257778
142SGK4940.31257778
143MAP3K50.31178798
144GSK3A0.30949264
145MAPK130.30437002
146LATS20.29614059
147STK240.29281767
148MARK10.28784348
149CDK80.28782348
150PRKCD0.27797005
151MAPK30.27599477

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.41264052
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.17495896
3* Malaria_Homo sapiens_hsa051443.07652346
4Steroid biosynthesis_Homo sapiens_hsa001003.05694458
5Nitrogen metabolism_Homo sapiens_hsa009102.80717174
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76030099
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.68833901
8ECM-receptor interaction_Homo sapiens_hsa045122.62833723
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60106094
10Focal adhesion_Homo sapiens_hsa045102.12356336
11Complement and coagulation cascades_Homo sapiens_hsa046102.11919619
12* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.00329148
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.97120702
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79940447
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.69734430
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66780570
17Amoebiasis_Homo sapiens_hsa051461.66709414
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65278928
19Small cell lung cancer_Homo sapiens_hsa052221.62513329
20Propanoate metabolism_Homo sapiens_hsa006401.61066396
21Staphylococcus aureus infection_Homo sapiens_hsa051501.59923672
22Adherens junction_Homo sapiens_hsa045201.57877127
23* TNF signaling pathway_Homo sapiens_hsa046681.55959858
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55722834
25Proteoglycans in cancer_Homo sapiens_hsa052051.53865919
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53632557
27Histidine metabolism_Homo sapiens_hsa003401.49579180
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47458525
29Butanoate metabolism_Homo sapiens_hsa006501.45285347
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43293452
31Leishmaniasis_Homo sapiens_hsa051401.42569045
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.41222636
33* Leukocyte transendothelial migration_Homo sapiens_hsa046701.39774034
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39368151
35TGF-beta signaling pathway_Homo sapiens_hsa043501.36797220
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33285684
37Protein digestion and absorption_Homo sapiens_hsa049741.27478909
38Dilated cardiomyopathy_Homo sapiens_hsa054141.27276993
39Viral myocarditis_Homo sapiens_hsa054161.26474347
40Osteoclast differentiation_Homo sapiens_hsa043801.26204577
41* African trypanosomiasis_Homo sapiens_hsa051431.26007963
42Fat digestion and absorption_Homo sapiens_hsa049751.25173327
43Toxoplasmosis_Homo sapiens_hsa051451.23776213
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22810180
45Lysosome_Homo sapiens_hsa041421.18811141
46Antigen processing and presentation_Homo sapiens_hsa046121.18113863
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16709724
48Bile secretion_Homo sapiens_hsa049761.15645529
49* NF-kappa B signaling pathway_Homo sapiens_hsa040641.11619409
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10488675
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06349000
52PPAR signaling pathway_Homo sapiens_hsa033201.05263747
53Fatty acid biosynthesis_Homo sapiens_hsa000611.04006085
54Legionellosis_Homo sapiens_hsa051341.02067868
55Pertussis_Homo sapiens_hsa051331.02058087
56Retinol metabolism_Homo sapiens_hsa008301.00949065
57Thyroid hormone synthesis_Homo sapiens_hsa049180.99108735
58Tryptophan metabolism_Homo sapiens_hsa003800.95320929
59Glycerolipid metabolism_Homo sapiens_hsa005610.94160577
60* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92992857
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.92762864
62Rheumatoid arthritis_Homo sapiens_hsa053230.91389938
63Notch signaling pathway_Homo sapiens_hsa043300.90318264
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90081603
65Basal cell carcinoma_Homo sapiens_hsa052170.89718765
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88723111
67Rap1 signaling pathway_Homo sapiens_hsa040150.87999865
68Chemokine signaling pathway_Homo sapiens_hsa040620.87865575
69Pathways in cancer_Homo sapiens_hsa052000.87768366
70Fatty acid elongation_Homo sapiens_hsa000620.86519806
71Hippo signaling pathway_Homo sapiens_hsa043900.86072417
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84519863
73Other glycan degradation_Homo sapiens_hsa005110.83263091
74Platelet activation_Homo sapiens_hsa046110.82801800
75Mineral absorption_Homo sapiens_hsa049780.82653084
76Caffeine metabolism_Homo sapiens_hsa002320.82251936
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81969397
78MicroRNAs in cancer_Homo sapiens_hsa052060.81517211
79Arachidonic acid metabolism_Homo sapiens_hsa005900.81348231
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80694752
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.79763923
82Dorso-ventral axis formation_Homo sapiens_hsa043200.79596283
83Apoptosis_Homo sapiens_hsa042100.79471372
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78298260
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78118733
86Measles_Homo sapiens_hsa051620.77422823
87Tuberculosis_Homo sapiens_hsa051520.75520416
88Pancreatic cancer_Homo sapiens_hsa052120.75089890
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74529226
90Circadian rhythm_Homo sapiens_hsa047100.74496261
91Peroxisome_Homo sapiens_hsa041460.74073978
92Salmonella infection_Homo sapiens_hsa051320.72672962
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70774611
94Hematopoietic cell lineage_Homo sapiens_hsa046400.70525420
95Influenza A_Homo sapiens_hsa051640.70455207
96Pancreatic secretion_Homo sapiens_hsa049720.70018982
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68922424
98Tight junction_Homo sapiens_hsa045300.68885694
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68586169
100Hepatitis B_Homo sapiens_hsa051610.66986559
101Chronic myeloid leukemia_Homo sapiens_hsa052200.66606247
102Melanoma_Homo sapiens_hsa052180.66337254
103Starch and sucrose metabolism_Homo sapiens_hsa005000.65097156
104Cocaine addiction_Homo sapiens_hsa050300.64915572
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64769573
106Arginine and proline metabolism_Homo sapiens_hsa003300.64555833
107Renin-angiotensin system_Homo sapiens_hsa046140.63446475
108Hedgehog signaling pathway_Homo sapiens_hsa043400.62961713
109Vitamin B6 metabolism_Homo sapiens_hsa007500.62715621
110ABC transporters_Homo sapiens_hsa020100.61944015
111Hepatitis C_Homo sapiens_hsa051600.61256811
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60776538
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60662975
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60626391
115Selenocompound metabolism_Homo sapiens_hsa004500.60084620
116* HTLV-I infection_Homo sapiens_hsa051660.59451979
117Glutathione metabolism_Homo sapiens_hsa004800.59443865
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.59240174
119Linoleic acid metabolism_Homo sapiens_hsa005910.58275407
120Fatty acid degradation_Homo sapiens_hsa000710.57230932
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57020065
122Fatty acid metabolism_Homo sapiens_hsa012120.56953455
123beta-Alanine metabolism_Homo sapiens_hsa004100.56937121
124Arginine biosynthesis_Homo sapiens_hsa002200.56131707
125Shigellosis_Homo sapiens_hsa051310.54532559
126Insulin resistance_Homo sapiens_hsa049310.54259229
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52555415
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52356924
129Phagosome_Homo sapiens_hsa041450.50868572
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50566049
131Ras signaling pathway_Homo sapiens_hsa040140.49555135
132Ovarian steroidogenesis_Homo sapiens_hsa049130.49140069
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48302675
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48199559
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47942234
136Vitamin digestion and absorption_Homo sapiens_hsa049770.47549878
137B cell receptor signaling pathway_Homo sapiens_hsa046620.47083629
138Bladder cancer_Homo sapiens_hsa052190.46544876
139Axon guidance_Homo sapiens_hsa043600.46115557
140Prostate cancer_Homo sapiens_hsa052150.45738264
141Choline metabolism in cancer_Homo sapiens_hsa052310.45439372
142Herpes simplex infection_Homo sapiens_hsa051680.44691570
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44135868
144Renin secretion_Homo sapiens_hsa049240.43533520
145Chemical carcinogenesis_Homo sapiens_hsa052040.43393659
146Prion diseases_Homo sapiens_hsa050200.43261046
147cAMP signaling pathway_Homo sapiens_hsa040240.42648099
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.42343533
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40394883
150Folate biosynthesis_Homo sapiens_hsa007900.39761031
151Asthma_Homo sapiens_hsa053100.36942357
152Pyruvate metabolism_Homo sapiens_hsa006200.36215463
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35952060
154Tyrosine metabolism_Homo sapiens_hsa003500.30481157
155Lysine degradation_Homo sapiens_hsa003100.29126497
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.27002827

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