VCAN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)6.84788253
2mesenchymal-epithelial cell signaling (GO:0060638)6.36057106
3craniofacial suture morphogenesis (GO:0097094)5.78293127
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.63855024
5cell proliferation involved in metanephros development (GO:0072203)5.52961874
6bone trabecula formation (GO:0060346)5.45184900
7sequestering of extracellular ligand from receptor (GO:0035581)4.97014088
8regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.86795389
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.85779151
10cell proliferation involved in kidney development (GO:0072111)4.83473737
11mesenchymal cell proliferation (GO:0010463)4.82282734
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.73194782
13regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.71464184
14prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.60347387
15regulation of non-canonical Wnt signaling pathway (GO:2000050)4.55242708
16cranial suture morphogenesis (GO:0060363)4.35785437
17radial glial cell differentiation (GO:0060019)4.29595009
18chondrocyte proliferation (GO:0035988)4.25684174
19detection of molecule of bacterial origin (GO:0032490)4.21011648
20outer ear morphogenesis (GO:0042473)4.15520965
21paraxial mesoderm development (GO:0048339)4.08761906
22embryonic cranial skeleton morphogenesis (GO:0048701)4.03375161
23head development (GO:0060322)3.98906679
24positive regulation by symbiont of host defense response (GO:0052509)3.97649701
25modulation by symbiont of host defense response (GO:0052031)3.97649701
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.97649701
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.97649701
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.97649701
29modulation by symbiont of host immune response (GO:0052553)3.97649701
30cellular extravasation (GO:0045123)3.84468604
31branching involved in prostate gland morphogenesis (GO:0060442)3.84234560
32metanephric mesenchyme development (GO:0072075)3.79523060
33hindlimb morphogenesis (GO:0035137)3.77697604
34mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.75606609
35hippo signaling (GO:0035329)3.74490646
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71457175
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.70981813
38axon extension involved in axon guidance (GO:0048846)3.70981813
39somite development (GO:0061053)3.70376373
40negative regulation of chondrocyte differentiation (GO:0032331)3.65023151
41proximal/distal pattern formation (GO:0009954)3.63997729
42convergent extension (GO:0060026)3.62221934
43positive regulation of gamma-delta T cell activation (GO:0046645)3.59429037
44response to peptidoglycan (GO:0032494)3.55293474
45kidney mesenchyme development (GO:0072074)3.55101019
46mesenchymal cell differentiation (GO:0048762)3.54083142
47negative regulation of catenin import into nucleus (GO:0035414)3.50782342
48embryonic hindlimb morphogenesis (GO:0035116)3.49292838
49branching involved in salivary gland morphogenesis (GO:0060445)3.44650879
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.44473220
51mesonephros development (GO:0001823)3.43736904
52organ induction (GO:0001759)3.42899428
53Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.40693391
54regulation of establishment of planar polarity (GO:0090175)3.39341417
55mitotic sister chromatid cohesion (GO:0007064)3.39013719
56glomerular filtration (GO:0003094)3.36464299
57embryonic skeletal joint morphogenesis (GO:0060272)3.34662734
58middle ear morphogenesis (GO:0042474)3.32172355
59regulation of macrophage cytokine production (GO:0010935)3.32069372
60embryonic forelimb morphogenesis (GO:0035115)3.31857803
61detection of other organism (GO:0098543)3.31783791
62heart morphogenesis (GO:0003007)3.30803656
63NLS-bearing protein import into nucleus (GO:0006607)3.28277477
64insulin-like growth factor receptor signaling pathway (GO:0048009)3.27886877
65regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.26731470
66chondrocyte development (GO:0002063)3.26316286
67embryonic appendage morphogenesis (GO:0035113)3.24762998
68embryonic limb morphogenesis (GO:0030326)3.24762998
69positive regulation of mesenchymal cell proliferation (GO:0002053)3.24723374
70mesenchyme morphogenesis (GO:0072132)3.24490228
71negative regulation of axon extension involved in axon guidance (GO:0048843)3.23558674
72microglial cell activation (GO:0001774)3.22165306
73renal system development (GO:0072001)3.20632273
74negative regulation of stem cell proliferation (GO:2000647)3.20574467
75appendage morphogenesis (GO:0035107)3.20451870
76limb morphogenesis (GO:0035108)3.20451870
77regulation of mesenchymal cell proliferation (GO:0010464)3.19624181
78negative regulation of DNA repair (GO:0045738)3.17807134
79branching involved in ureteric bud morphogenesis (GO:0001658)3.17568994
80endocardial cushion development (GO:0003197)3.17312523
81nerve growth factor signaling pathway (GO:0038180)3.17039194
82prostate gland epithelium morphogenesis (GO:0060740)3.15829965
83artery smooth muscle contraction (GO:0014824)3.14441553
84detection of external biotic stimulus (GO:0098581)3.12777424
85mesodermal cell differentiation (GO:0048333)3.11904823
86collagen fibril organization (GO:0030199)3.10631594
87dorsal/ventral axis specification (GO:0009950)3.10563327
88detection of biotic stimulus (GO:0009595)3.09362629
89cell migration involved in heart development (GO:0060973)3.09074418
90epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.08082671
91regulation of transforming growth factor beta2 production (GO:0032909)3.07275179
92macrophage activation involved in immune response (GO:0002281)3.06794907
93regulation of keratinocyte proliferation (GO:0010837)3.05674180
94negative regulation of cartilage development (GO:0061037)3.03646699
95regulation of chondrocyte differentiation (GO:0032330)3.03190722
96axis elongation (GO:0003401)3.03051251
97anatomical structure regression (GO:0060033)3.02660594
98body morphogenesis (GO:0010171)2.99779063
99G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.99230573
100regulation of morphogenesis of a branching structure (GO:0060688)2.97510674
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96894483
102negative regulation of cell killing (GO:0031342)2.96894483
103regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.95844515
104mesenchyme development (GO:0060485)2.95775852
105forelimb morphogenesis (GO:0035136)2.95415784
106negative chemotaxis (GO:0050919)2.95218220
107regulation of organ formation (GO:0003156)2.95200303
108renal filtration (GO:0097205)2.94561004
109regulation of catenin import into nucleus (GO:0035412)2.93502768
110organ formation (GO:0048645)2.92792306
111neutrophil mediated immunity (GO:0002446)2.92165148
112artery development (GO:0060840)2.91433507
113extracellular regulation of signal transduction (GO:1900115)2.91359956
114extracellular negative regulation of signal transduction (GO:1900116)2.91359956
115regulation of cartilage development (GO:0061035)2.90834203
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90069930
117positive regulation of smoothened signaling pathway (GO:0045880)2.89868347
118embryonic digit morphogenesis (GO:0042733)2.89365317
119midgut development (GO:0007494)2.88601331
120negative regulation of embryonic development (GO:0045992)2.87028087
121embryonic digestive tract morphogenesis (GO:0048557)2.86635381
122non-canonical Wnt signaling pathway (GO:0035567)2.86288587
123cochlea morphogenesis (GO:0090103)2.85022493
124cell wall macromolecule catabolic process (GO:0016998)2.84208780
125neutrophil activation involved in immune response (GO:0002283)2.82364885
126negative regulation of interleukin-12 production (GO:0032695)2.80376440
127pre-miRNA processing (GO:0031054)2.78105497
128phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.76316786
129response to host defenses (GO:0052200)2.73453066
130response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73453066
131response to host (GO:0075136)2.73453066
132negative regulation of translation, ncRNA-mediated (GO:0040033)2.73279170
133regulation of translation, ncRNA-mediated (GO:0045974)2.73279170
134negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73279170
135macrophage activation (GO:0042116)2.72485836
136response to host immune response (GO:0052572)2.70548560
137response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70548560
138pathway-restricted SMAD protein phosphorylation (GO:0060389)2.70466076
139gastrulation with mouth forming second (GO:0001702)2.68123921
140presynaptic membrane assembly (GO:0097105)2.65512974
141detection of bacterium (GO:0016045)2.64157973
142regulation of B cell receptor signaling pathway (GO:0050855)2.62036452
143histone H3-K36 demethylation (GO:0070544)2.61391088
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59636175
145glycoprotein catabolic process (GO:0006516)2.58310901
146activated T cell proliferation (GO:0050798)2.57142998
147positive regulation of cellular amide metabolic process (GO:0034250)2.56206576
148establishment of nucleus localization (GO:0040023)2.49140927
149regulation of NFAT protein import into nucleus (GO:0051532)2.48003224
150negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.43414196
151myeloid leukocyte mediated immunity (GO:0002444)2.43233150
152response to laminar fluid shear stress (GO:0034616)2.40220921
153regulation of gamma-delta T cell activation (GO:0046643)2.38245485
154positive regulation of mast cell activation (GO:0033005)2.38241787
155cardiac myofibril assembly (GO:0055003)2.37603131
156embryonic camera-type eye morphogenesis (GO:0048596)2.36770492
157myelin assembly (GO:0032288)2.36743101
158atrial septum morphogenesis (GO:0060413)2.36067603
159response to muramyl dipeptide (GO:0032495)2.34923769
160centrosome localization (GO:0051642)2.34714199
161cellular response to epinephrine stimulus (GO:0071872)2.33298851
162cytoplasmic mRNA processing body assembly (GO:0033962)2.32207272
163positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.31687368
164positive regulation of macrophage cytokine production (GO:0060907)2.31340686
165leukocyte migration involved in inflammatory response (GO:0002523)2.29304906
166nucleus localization (GO:0051647)2.28018656
167endodermal cell differentiation (GO:0035987)2.27103230
168pericardium development (GO:0060039)2.26960977
169regulation of cardioblast differentiation (GO:0051890)2.25967017
170platelet-derived growth factor receptor signaling pathway (GO:0048008)2.23055376
171regulation of interferon-beta biosynthetic process (GO:0045357)2.22904370
172regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.22456875
173phagocytosis, recognition (GO:0006910)2.21091457
174cellular response to fluid shear stress (GO:0071498)2.20374170
175regulation of mast cell activation (GO:0033003)2.20086171
176negative regulation of T cell mediated immunity (GO:0002710)2.19626519
177cell wall macromolecule metabolic process (GO:0044036)2.18877674
178histone H3-K9 demethylation (GO:0033169)2.18115969
179I-kappaB phosphorylation (GO:0007252)2.17557791
180basement membrane organization (GO:0071711)2.17451692
181histone lysine demethylation (GO:0070076)2.15434725
182heterotypic cell-cell adhesion (GO:0034113)2.15181873
183respiratory burst (GO:0045730)2.13228404
184regulation of chemokine-mediated signaling pathway (GO:0070099)2.12920733
185embryonic process involved in female pregnancy (GO:0060136)2.12695418
186cardiac muscle hypertrophy (GO:0003300)2.10951358
187antigen processing and presentation via MHC class Ib (GO:0002475)2.10345191
188Notch signaling involved in heart development (GO:0061314)2.10276771
189regulation of cardiac muscle cell differentiation (GO:2000725)2.10000475
190histone H3-K4 trimethylation (GO:0080182)2.09739647
191retina vasculature morphogenesis in camera-type eye (GO:0061299)2.09091080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.68147792
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.76159398
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.62267446
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.30292744
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.08615457
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.96959135
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.63281770
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.47173779
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41461913
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.41204383
11* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.29548222
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25600515
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.23711897
14* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.22934239
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13277189
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08483651
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96886309
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93233464
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.91787865
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.91598004
21* ISL1_27105846_Chip-Seq_CPCs_Mouse1.87579002
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.86113673
23EZH2_22144423_ChIP-Seq_EOC_Human1.85383609
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.82678031
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80312572
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79084852
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.76547723
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71370534
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.69283580
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69234196
31* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67808317
32* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67808317
33BRD4_25478319_ChIP-Seq_HGPS_Human1.65010982
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64150403
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.62573100
36FUS_26573619_Chip-Seq_HEK293_Human1.62077851
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60636398
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60036049
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59565910
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57980310
41E2F7_22180533_ChIP-Seq_HELA_Human1.55948771
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55760922
43AR_21572438_ChIP-Seq_LNCaP_Human1.53929883
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53105457
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52295063
46TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51682309
47TP53_18474530_ChIP-ChIP_U2OS_Human1.50962418
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50290400
49VDR_24787735_ChIP-Seq_THP-1_Human1.50271077
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49864286
51TAF15_26573619_Chip-Seq_HEK293_Human1.46760469
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46667155
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.45600216
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45135617
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.44674847
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44635388
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.43452207
58EWS_26573619_Chip-Seq_HEK293_Human1.43443831
59* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42278921
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41151661
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.40918329
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.40568684
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39515380
64GBX2_23144817_ChIP-Seq_PC3_Human1.39327448
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38538017
66* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38255881
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37727383
68* RNF2_27304074_Chip-Seq_ESCs_Mouse1.36909632
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36028107
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35246376
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33584245
72* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31586818
73* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30872752
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30277811
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.29272963
76* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28940337
77* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28940337
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.28263672
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.28211605
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25828939
81AHR_22903824_ChIP-Seq_MCF-7_Human1.24091283
82TP53_16413492_ChIP-PET_HCT116_Human1.23258531
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23002271
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.22690501
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21830981
86RUNX_20019798_ChIP-Seq_JUKART_Human1.21147257
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20998563
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20311565
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19845266
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19499484
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18870876
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18323309
93* P300_19829295_ChIP-Seq_ESCs_Human1.18102537
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17092471
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17051229
96* CJUN_26792858_Chip-Seq_BT549_Human1.16307582
97* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16171945
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.15703157
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.15614274
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15557353
101STAT3_23295773_ChIP-Seq_U87_Human1.15005425
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14515229
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13298480
104* SMAD4_21799915_ChIP-Seq_A2780_Human1.12599630
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12514938
106* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11783115
107BCAT_22108803_ChIP-Seq_LS180_Human1.10853650
108* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10731396
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09784588
110KDM2B_26808549_Chip-Seq_REH_Human1.09595722
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09132580
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09132580
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08147201
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06787227
115* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06226190
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.05660232
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05617067
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05241411
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.05219012
120RXR_22108803_ChIP-Seq_LS180_Human1.04936141
121CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04083126
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03755870
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03020573
124SOX9_26525672_Chip-Seq_HEART_Mouse1.02476095
125ZNF274_21170338_ChIP-Seq_K562_Hela1.00406750
126* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00250066
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98946334
128* TCF4_23295773_ChIP-Seq_U87_Human0.98647050
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97498162
130* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97360694
131* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97239681
132FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96268828
133* RING1B_27294783_Chip-Seq_ESCs_Mouse0.95468382
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95033272
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95033272
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95033272
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94062075
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.93867791
139GF1_26923725_Chip-Seq_HPCs_Mouse0.93723276
140* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93642044
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93401054
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92796114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.42123241
2MP0008438_abnormal_cutaneous_collagen3.46535703
3MP0002938_white_spotting3.42369135
4MP0009250_abnormal_appendicular_skeleto3.12391416
5MP0010030_abnormal_orbit_morphology2.98710378
6MP0003828_pulmonary_edema2.87850016
7MP0009053_abnormal_anal_canal2.83726557
8MP0003385_abnormal_body_wall2.81214256
9MP0003942_abnormal_urinary_system2.77259896
10MP0003724_increased_susceptibility_to2.59122412
11MP0004272_abnormal_basement_membrane2.51291697
12MP0000537_abnormal_urethra_morphology2.49460127
13MP0001299_abnormal_eye_distance/2.48595214
14MP0000566_synostosis2.43331810
15MP0003122_maternal_imprinting2.40447157
16MP0002009_preneoplasia2.31414382
17MP0001293_anophthalmia2.27024922
18MP0003937_abnormal_limbs/digits/tail_de2.26250232
19MP0005187_abnormal_penis_morphology2.25021987
20MP0005248_abnormal_Harderian_gland2.24295173
21MP0000428_abnormal_craniofacial_morphol2.22620330
22MP0003705_abnormal_hypodermis_morpholog2.18169917
23MP0002282_abnormal_trachea_morphology2.17137106
24MP0003091_abnormal_cell_migration2.16730115
25MP0000534_abnormal_ureter_morphology2.07301028
26MP0005275_abnormal_skin_tensile2.06900529
27MP0000049_abnormal_middle_ear2.06385987
28MP0003755_abnormal_palate_morphology1.99370738
29MP0003566_abnormal_cell_adhesion1.97435171
30MP0003300_gastrointestinal_ulcer1.95644096
31MP0008057_abnormal_DNA_replication1.94134082
32MP0003935_abnormal_craniofacial_develop1.94089517
33MP0005257_abnormal_intraocular_pressure1.88209207
34MP0000516_abnormal_urinary_system1.85492003
35MP0005367_renal/urinary_system_phenotyp1.85492003
36MP0005508_abnormal_skeleton_morphology1.83326835
37MP0002249_abnormal_larynx_morphology1.82170803
38MP0003283_abnormal_digestive_organ1.81699899
39MP0002932_abnormal_joint_morphology1.81323204
40MP0000569_abnormal_digit_pigmentation1.78763818
41MP0003121_genomic_imprinting1.73843424
42MP0002108_abnormal_muscle_morphology1.73359492
43MP0009384_cardiac_valve_regurgitation1.70927409
44MP0000762_abnormal_tongue_morphology1.69616592
45MP0003123_paternal_imprinting1.69364249
46MP0000733_abnormal_muscle_development1.68929389
47MP0002116_abnormal_craniofacial_bone1.64327401
48MP0004134_abnormal_chest_morphology1.64185875
49MP0003941_abnormal_skin_development1.62194077
50MP0003303_peritoneal_inflammation1.56371115
51MP0000432_abnormal_head_morphology1.55845165
52MP0002109_abnormal_limb_morphology1.55495828
53MP0002133_abnormal_respiratory_system1.51898194
54MP0005388_respiratory_system_phenotype1.51898194
55MP0003115_abnormal_respiratory_system1.47687180
56MP0003279_aneurysm1.44611164
57MP0004883_abnormal_blood_vessel1.43488836
58MP0004084_abnormal_cardiac_muscle1.42796061
59MP0005171_absent_coat_pigmentation1.40639512
60MP0001835_abnormal_antigen_presentation1.39487646
61MP0002233_abnormal_nose_morphology1.39213249
62MP0002177_abnormal_outer_ear1.38765424
63MP0003436_decreased_susceptibility_to1.38715154
64MP0000163_abnormal_cartilage_morphology1.37154804
65MP0003938_abnormal_ear_development1.36797652
66MP0002115_abnormal_skeleton_extremities1.36585446
67MP0001915_intracranial_hemorrhage1.36251864
68MP0003690_abnormal_glial_cell1.35624416
69MP0008260_abnormal_autophagy1.35150787
70MP0001851_eye_inflammation1.32812294
71MP0003172_abnormal_lysosome_physiology1.30434615
72MP0002822_catalepsy1.28616587
73MP0002998_abnormal_bone_remodeling1.27083814
74MP0005076_abnormal_cell_differentiation1.25429993
75MP0008004_abnormal_stomach_pH1.23872451
76MP0004510_myositis1.23290992
77MP0002896_abnormal_bone_mineralization1.18830649
78MP0003221_abnormal_cardiomyocyte_apopto1.18262727
79MP0001958_emphysema1.17986947
80MP0010368_abnormal_lymphatic_system1.17895576
81MP0002102_abnormal_ear_morphology1.17042504
82MP0000579_abnormal_nail_morphology1.16877190
83MP0002127_abnormal_cardiovascular_syste1.16850243
84MP0002419_abnormal_innate_immunity1.16544041
85MP0003567_abnormal_fetal_cardiomyocyte1.15371096
86MP0002092_abnormal_eye_morphology1.12932303
87MP0005409_darkened_coat_color1.12452062
88MP0002113_abnormal_skeleton_development1.11160635
89MP0002114_abnormal_axial_skeleton1.10843909
90MP0003890_abnormal_embryonic-extraembry1.09238437
91MP0001346_abnormal_lacrimal_gland1.08524431
92MP0001340_abnormal_eyelid_morphology1.07839944
93MP0010352_gastrointestinal_tract_polyps1.06546572
94MP0004197_abnormal_fetal_growth/weight/1.06165736
95MP0002166_altered_tumor_susceptibility1.05980821
96MP0009703_decreased_birth_body1.02747870
97MP0002111_abnormal_tail_morphology1.02153574
98MP0003448_altered_tumor_morphology1.00726250
99MP0002085_abnormal_embryonic_tissue0.99302871
100MP0000767_abnormal_smooth_muscle0.98129981
101MP0005390_skeleton_phenotype0.98111511
102MP0005164_abnormal_response_to0.96678845
103MP0002089_abnormal_postnatal_growth/wei0.96246748
104* MP0002925_abnormal_cardiovascular_devel0.95884728
105MP0004858_abnormal_nervous_system0.94361613
106MP0006082_CNS_inflammation0.93261064
107MP0002084_abnormal_developmental_patter0.91502347
108MP0005623_abnormal_meninges_morphology0.91488141
109MP0002060_abnormal_skin_morphology0.90652278
110MP0000465_gastrointestinal_hemorrhage0.90558346
111MP0001175_abnormal_lung_morphology0.90208676
112MP0002006_tumorigenesis0.88845551
113MP0001614_abnormal_blood_vessel0.88598346
114MP0001533_abnormal_skeleton_physiology0.88552828
115MP0002295_abnormal_pulmonary_circulatio0.88462525
116MP0003119_abnormal_digestive_system0.88370755
117MP0000462_abnormal_digestive_system0.87663969
118MP0009278_abnormal_bone_marrow0.85770985
119MP0002168_other_aberrant_phenotype0.83689102
120MP0006054_spinal_hemorrhage0.83678454
121MP0002697_abnormal_eye_size0.83617525
122MP0002128_abnormal_blood_circulation0.81839932
123MP0002088_abnormal_embryonic_growth/wei0.81764416
124MP0001849_ear_inflammation0.81355723
125MP0001286_abnormal_eye_development0.81084450
126MP0000427_abnormal_hair_cycle0.80883526
127MP0000647_abnormal_sebaceous_gland0.80555479
128MP0003045_fibrosis0.80181098
129MP0001270_distended_abdomen0.79892318
130MP0001177_atelectasis0.78907844
131MP0002751_abnormal_autonomic_nervous0.77760183
132MP0003943_abnormal_hepatobiliary_system0.77656761
133MP0004808_abnormal_hematopoietic_stem0.76600322
134MP0003984_embryonic_growth_retardation0.75185439
135MP0010630_abnormal_cardiac_muscle0.74575216
136MP0004145_abnormal_muscle_electrophysio0.74532469
137MP0008775_abnormal_heart_ventricle0.73913007
138MP0005023_abnormal_wound_healing0.73835075
139MP0001243_abnormal_dermal_layer0.72749642
140MP0003632_abnormal_nervous_system0.71964927
141MP0002081_perinatal_lethality0.71895446
142* MP0000266_abnormal_heart_morphology0.71718028
143MP0010307_abnormal_tumor_latency0.71273243
144MP0002098_abnormal_vibrissa_morphology0.71073248
145MP0003861_abnormal_nervous_system0.70360918
146MP0002933_joint_inflammation0.69678801
147MP0000778_abnormal_nervous_system0.68834314
148MP0004484_altered_response_of0.68448529
149MP0004233_abnormal_muscle_weight0.68372506
150MP0005621_abnormal_cell_physiology0.68344981
151MP0005380_embryogenesis_phenotype0.68110463
152MP0001672_abnormal_embryogenesis/_devel0.68110463
153MP0003795_abnormal_bone_structure0.67408756

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)6.65319417
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)6.65319417
3Midline defect of the nose (HP:0004122)4.98091011
4Abnormality of the parietal bone (HP:0002696)4.97655545
5Abnormality of the 4th metacarpal (HP:0010012)4.89341427
6Shallow orbits (HP:0000586)4.18825776
7Trigonocephaly (HP:0000243)4.09905067
8Broad metatarsal (HP:0001783)3.54727503
9Microglossia (HP:0000171)3.52890113
10Protrusio acetabuli (HP:0003179)3.52715649
11Papillary thyroid carcinoma (HP:0002895)3.16252203
12Abnormality of the nasal septum (HP:0000419)3.11389700
13Coronal craniosynostosis (HP:0004440)3.03818011
14Nasolacrimal duct obstruction (HP:0000579)3.03442245
15Arterial tortuosity (HP:0005116)3.02373033
16Abnormality of the nasolacrimal system (HP:0000614)3.01030767
17Absent frontal sinuses (HP:0002688)2.98975497
18Anteriorly placed anus (HP:0001545)2.98529274
19Abnormality of the distal phalanx of the thumb (HP:0009617)2.97832532
20Mitral valve prolapse (HP:0001634)2.92827633
21Spondylolisthesis (HP:0003302)2.90548145
22Overgrowth (HP:0001548)2.78275201
23Vascular tortuosity (HP:0004948)2.77795836
24Broad toe (HP:0001837)2.77249537
25Recurrent bacterial skin infections (HP:0005406)2.75436484
26Dilatation of the ascending aorta (HP:0005111)2.74844568
27Spinal cord lesions (HP:0100561)2.74249594
28Syringomyelia (HP:0003396)2.74249594
29Abnormality of the lacrimal duct (HP:0011481)2.73704786
30Eczematoid dermatitis (HP:0000976)2.72766469
31Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.70604957
32Increased number of teeth (HP:0011069)2.63771676
33Mesomelia (HP:0003027)2.62926396
34Supernumerary ribs (HP:0005815)2.62897821
35Narrow palate (HP:0000189)2.61647668
36Bell-shaped thorax (HP:0001591)2.53425626
37Recurrent abscess formation (HP:0002722)2.50417673
38Alacrima (HP:0000522)2.49004702
39Abnormal number of incisors (HP:0011064)2.45348393
40Broad hallux (HP:0010055)2.42217152
41Hepatoblastoma (HP:0002884)2.41460176
42Exostoses (HP:0100777)2.39833403
43Abnormality of the diencephalon (HP:0010662)2.38078156
44Subacute progressive viral hepatitis (HP:0006572)2.37768722
45Wide anterior fontanel (HP:0000260)2.37303160
46Recurrent gram-negative bacterial infections (HP:0005420)2.35986884
47Supernumerary bones of the axial skeleton (HP:0009144)2.35526026
48Broad thumb (HP:0011304)2.33691282
49Hypoplastic labia majora (HP:0000059)2.33318745
50Turricephaly (HP:0000262)2.32515720
51Partial duplication of the phalanx of hand (HP:0009999)2.31328455
52Premature rupture of membranes (HP:0001788)2.30892557
53Broad face (HP:0000283)2.30369567
54Hypoplasia of the maxilla (HP:0000327)2.29934941
55Cutaneous finger syndactyly (HP:0010554)2.29811425
56Gingivitis (HP:0000230)2.28912439
57Periodontitis (HP:0000704)2.25836889
58Broad ribs (HP:0000885)2.25524866
59Abnormality of the incisor (HP:0000676)2.21896687
60Short phalanx of the thumb (HP:0009660)2.20650714
61Large earlobe (HP:0009748)2.20185375
62Infantile muscular hypotonia (HP:0008947)2.19488025
63Atrophic scars (HP:0001075)2.19165659
64Renal duplication (HP:0000075)2.18747352
65Cerebral aneurysm (HP:0004944)2.18216511
66Neoplasm of the heart (HP:0100544)2.17844123
67Abnormality of the phalanges of the hallux (HP:0010057)2.15456505
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.14917147
69Sparse lateral eyebrow (HP:0005338)2.13655116
70White forelock (HP:0002211)2.12725637
71Gastrointestinal infarctions (HP:0005244)2.12446233
72Spontaneous hematomas (HP:0007420)2.12070717
73Broad long bones (HP:0005622)2.11859667
74Optic neuritis (HP:0100653)2.11288750
75Retrobulbar optic neuritis (HP:0100654)2.11288750
76Genu recurvatum (HP:0002816)2.09440799
77Abnormality of the labia majora (HP:0012881)2.08987250
78Broad phalanx (HP:0006009)2.08188175
79Ankle contracture (HP:0006466)2.07955455
80Broad palm (HP:0001169)2.07109787
81Relative macrocephaly (HP:0004482)2.06929160
82Abnormality of the labia minora (HP:0012880)2.06762057
83Aplasia cutis congenita (HP:0001057)2.06223905
84Orchitis (HP:0100796)2.06061400
85Pulmonic stenosis (HP:0001642)2.03814543
86Aortic dissection (HP:0002647)2.03576643
87Rectal fistula (HP:0100590)2.02933168
88Rectovaginal fistula (HP:0000143)2.02933168
89Decreased lacrimation (HP:0000633)2.01195931
90Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.01098466
91Broad phalanges of the hand (HP:0009768)1.98846695
92Intestinal fistula (HP:0100819)1.98780779
93Anophthalmia (HP:0000528)1.98649063
94Asymmetry of the thorax (HP:0001555)1.98460223
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98168921
96Short metatarsal (HP:0010743)1.98029214
97Myositis (HP:0100614)1.97524139
98Broad finger (HP:0001500)1.96940904
99Cutaneous syndactyly (HP:0012725)1.96893051
100Limited hip movement (HP:0008800)1.96775623
101Abnormality of incisor morphology (HP:0011063)1.96619856
102Deep philtrum (HP:0002002)1.94670140
103Abnormality of macrophages (HP:0004311)1.93745911
104Short middle phalanx of the 5th finger (HP:0004220)1.92466192
105Peritonitis (HP:0002586)1.91686739
106Aortic aneurysm (HP:0004942)1.91531801
107Hematochezia (HP:0002573)1.90687026
108Preaxial foot polydactyly (HP:0001841)1.90659595
109Amyloidosis (HP:0011034)1.90591096
110Abnormality of the middle phalanges of the hand (HP:0009833)1.90589769
111Abnormality of the proximal phalanges of the hand (HP:0009834)1.90549330
112Deviation of the hallux (HP:0010051)1.90535683
113Wide cranial sutures (HP:0010537)1.89258713
114Joint laxity (HP:0001388)1.89196047
115Fragile skin (HP:0001030)1.88991993
116Disproportionate tall stature (HP:0001519)1.88991743
117Aneurysm (HP:0002617)1.88728810
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88511019
119Wormian bones (HP:0002645)1.88333230
120Vertebral arch anomaly (HP:0008438)1.88289659
121Pulmonary artery stenosis (HP:0004415)1.87474523
122Soft skin (HP:0000977)1.86321291
123Dislocated radial head (HP:0003083)1.84862739
124Depressed nasal tip (HP:0000437)1.83823789
125Long eyelashes (HP:0000527)1.83538161
126Aqueductal stenosis (HP:0002410)1.83395989
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.83011662
128Osteolytic defects of the hand bones (HP:0009699)1.83011662
129Protruding ear (HP:0000411)1.81808419
130Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80911920
131Bilateral microphthalmos (HP:0007633)1.79950032
132Aplasia involving bones of the extremities (HP:0009825)1.79899614
133Aplasia involving bones of the upper limbs (HP:0009823)1.79899614
134Aplasia of the phalanges of the hand (HP:0009802)1.79899614
135Patchy hypopigmentation of hair (HP:0011365)1.78230318
136Gingival bleeding (HP:0000225)1.78167886
137Short clavicles (HP:0000894)1.77680440
138Cervical subluxation (HP:0003308)1.77197623
139Buphthalmos (HP:0000557)1.76909972
140Abnormality of the ischium (HP:0003174)1.76860565
141Wrist flexion contracture (HP:0001239)1.76677371
142Concave nail (HP:0001598)1.75298179
143Neoplasm of the oral cavity (HP:0100649)1.74687983
144Mitral regurgitation (HP:0001653)1.74594925
145Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.73679978
146Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72319572
147Abnormality of the 2nd finger (HP:0004100)1.71363928
148Bladder diverticulum (HP:0000015)1.71340646
149Decreased skull ossification (HP:0004331)1.71314037
150Abnormality of the peritoneum (HP:0002585)1.70741800
151Ectopia lentis (HP:0001083)1.70664859
152Thyroid carcinoma (HP:0002890)1.70065107
153Down-sloping shoulders (HP:0200021)1.70040279
154Tracheomalacia (HP:0002779)1.69787324
155Hyperextensible skin (HP:0000974)1.69755802
156Neonatal short-limb short stature (HP:0008921)1.69275677
157Blue sclerae (HP:0000592)1.68734856
158Mild short stature (HP:0003502)1.68474180
159Hip contracture (HP:0003273)1.68273006
160Difficulty running (HP:0009046)1.67155833
161Abnormality of skull ossification (HP:0002703)1.63705500
162Mitral stenosis (HP:0001718)1.63664351
163Abnormal platelet volume (HP:0011876)1.63524634
164Abnormality of the radial head (HP:0003995)1.62915759
165Recurrent skin infections (HP:0001581)1.60923641
166Flared iliac wings (HP:0002869)1.57846749
167Excessive salivation (HP:0003781)1.57653637
168Abnormality of the fingertips (HP:0001211)1.56878010
169Abnormality of dentin (HP:0010299)1.56403567
170Drooling (HP:0002307)1.55756693
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55531696
172Abnormality of the epiphyses of the hand (HP:0005924)1.54949914
173Bicuspid aortic valve (HP:0001647)1.53301946
174Keratoconjunctivitis sicca (HP:0001097)1.53202921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.18653251
2DDR24.57904889
3CASK4.13344363
4FGFR23.71063290
5EPHA33.36099640
6PDGFRA3.20446800
7SIK12.90056968
8CDK122.60031142
9BLK2.58171115
10FGFR12.43754235
11EPHB22.24251363
12STK32.17042074
13CAMK1G2.16347624
14CAMK1D2.16129767
15RIPK42.03706414
16FGR1.95150999
17LATS21.90214370
18NUAK11.88974216
19ERBB31.88376610
20MAP3K61.76558030
21DMPK1.76065608
22PRPF4B1.75292095
23PIK3CA1.73656621
24CSK1.72806548
25TTN1.65558522
26MKNK11.65229587
27FES1.60772924
28BRD41.60360192
29FLT31.57654440
30MARK11.54405913
31BMX1.51018339
32PDGFRB1.49982021
33OBSCN1.48331219
34TNIK1.46298232
35MAPK71.45857646
36TYK21.44433373
37YES11.42289325
38MAP2K31.38821046
39AKT31.38099953
40MTOR1.34678617
41WNK11.33167349
42SGK4941.23387123
43SGK2231.23387123
44NEK91.21983885
45PIK3CG1.19457165
46JAK11.15489745
47STK38L1.12356011
48RIPK11.11746946
49CSNK1A1L1.07140284
50ICK1.05517663
51MAP3K101.04545159
52ERBB21.04251421
53WNK31.03660599
54CDC71.03182424
55KSR21.02228538
56PRKD31.01057986
57PLK21.00899677
58PAK20.98480446
59ZAP700.97278857
60NLK0.96547675
61PLK30.95596975
62PTK20.94151997
63JAK20.94095354
64MAP2K40.92645596
65HCK0.89409865
66CDC42BPA0.88957711
67MAP3K20.88718874
68JAK30.86023377
69STK380.85395563
70TEC0.84228942
71MARK20.84205930
72ZAK0.79928158
73CHEK20.78948209
74EPHB10.78865799
75MAP3K140.77860390
76NTRK30.77332584
77ROCK10.76647189
78FER0.75897177
79RPS6KA40.74791052
80PTK60.73987344
81TGFBR10.73674037
82BTK0.73112117
83PKN20.73076095
84MAP3K40.72940404
85EIF2AK20.71601935
86CSF1R0.70782494
87CDK60.70278472
88MET0.68589810
89IRAK40.68440791
90KIT0.67512818
91MKNK20.67490324
92ATR0.67337857
93TRIB30.65840622
94KSR10.65053823
95RAF10.64714287
96CAMK40.64538779
97SIK30.64146352
98FGFR30.63874441
99LYN0.63628245
100ATM0.63147783
101IRAK10.63016063
102DYRK20.60588970
103CHUK0.60267176
104CDK70.59628704
105DYRK30.59453276
106TGFBR20.58225267
107FRK0.57915403
108MAPK10.57524229
109SGK30.56606869
110SYK0.56220487
111STK110.55399568
112CSNK1G10.55169320
113EGFR0.53894144
114FYN0.53678359
115RPS6KA20.53402680
116NEK20.53030429
117CDK10.51150066
118MAP3K50.50667767
119PRKCH0.49821295
120FGFR40.49054682
121DYRK1A0.48487354
122CHEK10.47513441
123ADRBK10.47441391
124MELK0.47415494
125PTK2B0.46486285
126LCK0.45900495
127SGK20.45613266
128MAPK80.45414234
129GRK60.45215952
130TRPM70.44059607
131INSR0.44033677
132MAPK140.43331771
133STK40.43067056
134IRAK20.42453336
135RPS6KC10.42220643
136RPS6KL10.42220643
137MAP3K70.42079824
138MAP3K10.41565766
139AKT10.41277842
140IGF1R0.40471593
141PRKCE0.38302659
142CDK40.37802964
143STK240.37253312
144CDK80.37175240
145PAK40.34684885
146PAK30.34583622
147GSK3A0.34139474
148GSK3B0.33860578
149CDK20.33430855
150MAPK130.33342230
151TAOK20.31410066
152CSNK1D0.30839561
153PRKD10.30717520
154CDK90.30704173
155PRKDC0.30575403
156RET0.30288931
157SRC0.30206345

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.56964669
2Hedgehog signaling pathway_Homo sapiens_hsa043404.01658223
3Adherens junction_Homo sapiens_hsa045202.67135785
4ECM-receptor interaction_Homo sapiens_hsa045122.56910666
5TGF-beta signaling pathway_Homo sapiens_hsa043502.53854130
6Hippo signaling pathway_Homo sapiens_hsa043902.48985847
7Wnt signaling pathway_Homo sapiens_hsa043102.31488170
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.21930629
9Proteoglycans in cancer_Homo sapiens_hsa052052.15151547
10MicroRNAs in cancer_Homo sapiens_hsa052062.14206582
11Focal adhesion_Homo sapiens_hsa045102.07791652
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.06058078
13Prostate cancer_Homo sapiens_hsa052151.92791507
14Melanoma_Homo sapiens_hsa052181.92389423
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91287812
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90212635
17Dilated cardiomyopathy_Homo sapiens_hsa054141.88018071
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82899340
19Osteoclast differentiation_Homo sapiens_hsa043801.80861237
20Axon guidance_Homo sapiens_hsa043601.79525532
21Pathways in cancer_Homo sapiens_hsa052001.75373207
22Colorectal cancer_Homo sapiens_hsa052101.73392144
23Viral myocarditis_Homo sapiens_hsa054161.72004373
24Small cell lung cancer_Homo sapiens_hsa052221.69640460
25Leishmaniasis_Homo sapiens_hsa051401.67051071
26Cell cycle_Homo sapiens_hsa041101.54600611
27Lysine degradation_Homo sapiens_hsa003101.54374702
28Chronic myeloid leukemia_Homo sapiens_hsa052201.43373755
29Endometrial cancer_Homo sapiens_hsa052131.41395704
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37994474
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36177817
32Protein digestion and absorption_Homo sapiens_hsa049741.33297736
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27992326
34Dorso-ventral axis formation_Homo sapiens_hsa043201.27966514
35Melanogenesis_Homo sapiens_hsa049161.27789457
36Amoebiasis_Homo sapiens_hsa051461.25279505
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24161903
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21437416
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20552620
40HTLV-I infection_Homo sapiens_hsa051661.19842714
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19068676
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18586213
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17912516
44B cell receptor signaling pathway_Homo sapiens_hsa046621.17570302
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15522235
46Tuberculosis_Homo sapiens_hsa051521.10759458
47Glioma_Homo sapiens_hsa052141.10431207
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09109329
49Rap1 signaling pathway_Homo sapiens_hsa040151.06990786
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.05458571
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99574141
52Staphylococcus aureus infection_Homo sapiens_hsa051500.97745885
53Thyroid cancer_Homo sapiens_hsa052160.96508680
54Chemokine signaling pathway_Homo sapiens_hsa040620.96310283
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95399231
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94341425
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92333004
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91659637
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90461123
60Tight junction_Homo sapiens_hsa045300.90197571
61Pancreatic cancer_Homo sapiens_hsa052120.89376379
62Renal cell carcinoma_Homo sapiens_hsa052110.86934699
63T cell receptor signaling pathway_Homo sapiens_hsa046600.86551818
64Long-term potentiation_Homo sapiens_hsa047200.85998762
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.85441534
66Legionellosis_Homo sapiens_hsa051340.82844499
67Notch signaling pathway_Homo sapiens_hsa043300.81683264
68ErbB signaling pathway_Homo sapiens_hsa040120.81385021
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80920634
70Inositol phosphate metabolism_Homo sapiens_hsa005620.80260547
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.79883587
72mTOR signaling pathway_Homo sapiens_hsa041500.78786112
73MAPK signaling pathway_Homo sapiens_hsa040100.76000858
74Long-term depression_Homo sapiens_hsa047300.76000508
75Toxoplasmosis_Homo sapiens_hsa051450.75125901
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74427083
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73310024
78mRNA surveillance pathway_Homo sapiens_hsa030150.72987119
79Salmonella infection_Homo sapiens_hsa051320.72463779
80Bladder cancer_Homo sapiens_hsa052190.72370543
81p53 signaling pathway_Homo sapiens_hsa041150.72369175
82cAMP signaling pathway_Homo sapiens_hsa040240.71936678
83FoxO signaling pathway_Homo sapiens_hsa040680.71027714
84Hepatitis B_Homo sapiens_hsa051610.70665880
85Type II diabetes mellitus_Homo sapiens_hsa049300.70462832
86Oocyte meiosis_Homo sapiens_hsa041140.69421609
87Measles_Homo sapiens_hsa051620.68983261
88Malaria_Homo sapiens_hsa051440.66478246
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66184880
90Ras signaling pathway_Homo sapiens_hsa040140.65842023
91Influenza A_Homo sapiens_hsa051640.65322194
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.64388498
93African trypanosomiasis_Homo sapiens_hsa051430.63887681
94Phagosome_Homo sapiens_hsa041450.63509247
95Viral carcinogenesis_Homo sapiens_hsa052030.62684542
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62408870
97Hematopoietic cell lineage_Homo sapiens_hsa046400.62315344
98Renin secretion_Homo sapiens_hsa049240.62288432
99Cholinergic synapse_Homo sapiens_hsa047250.62123822
100Non-small cell lung cancer_Homo sapiens_hsa052230.61698426
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61567845
102TNF signaling pathway_Homo sapiens_hsa046680.61401078
103Pertussis_Homo sapiens_hsa051330.60701687
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.59885857
105Insulin resistance_Homo sapiens_hsa049310.59760893
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57845378
107Gap junction_Homo sapiens_hsa045400.57774285
108Shigellosis_Homo sapiens_hsa051310.57742492
109Estrogen signaling pathway_Homo sapiens_hsa049150.55805790
110Platelet activation_Homo sapiens_hsa046110.54561279
111AMPK signaling pathway_Homo sapiens_hsa041520.54337164
112Ovarian steroidogenesis_Homo sapiens_hsa049130.48477460
113HIF-1 signaling pathway_Homo sapiens_hsa040660.48402683
114Acute myeloid leukemia_Homo sapiens_hsa052210.47405804
115Insulin signaling pathway_Homo sapiens_hsa049100.44249173
116RNA transport_Homo sapiens_hsa030130.40724375
117Fanconi anemia pathway_Homo sapiens_hsa034600.39639189
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.39097910
119Renin-angiotensin system_Homo sapiens_hsa046140.39048596
120Herpes simplex infection_Homo sapiens_hsa051680.38824643
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37640037
122* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37636635
123Choline metabolism in cancer_Homo sapiens_hsa052310.35788257
124RNA degradation_Homo sapiens_hsa030180.33941885
125Cocaine addiction_Homo sapiens_hsa050300.33601808
126Glucagon signaling pathway_Homo sapiens_hsa049220.31872444
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30886172
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30437150
129GnRH signaling pathway_Homo sapiens_hsa049120.29756585
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.28072544
131Prolactin signaling pathway_Homo sapiens_hsa049170.28047821
132Thyroid hormone synthesis_Homo sapiens_hsa049180.27362454
133Oxytocin signaling pathway_Homo sapiens_hsa049210.25387289

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