VCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.57291808
2collagen fibril organization (GO:0030199)5.28280232
3cell adhesion mediated by integrin (GO:0033627)5.25760821
4endodermal cell differentiation (GO:0035987)4.95872217
5plasma membrane repair (GO:0001778)4.73112984
6protein heterotrimerization (GO:0070208)4.70195546
7wound healing, spreading of epidermal cells (GO:0035313)4.49582620
8sequestering of extracellular ligand from receptor (GO:0035581)4.42459575
9positive regulation of endothelial cell apoptotic process (GO:2000353)4.37113615
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.35661764
11negative regulation of fatty acid transport (GO:2000192)4.30022295
12skin morphogenesis (GO:0043589)4.22587563
13basement membrane organization (GO:0071711)3.99663242
14endocardial cushion development (GO:0003197)3.95811415
15hippo signaling (GO:0035329)3.91682221
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.83261636
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.82449447
18axon extension involved in axon guidance (GO:0048846)3.82449447
19nuclear pore complex assembly (GO:0051292)3.80084848
20vascular endothelial growth factor signaling pathway (GO:0038084)3.75188142
21wound healing, spreading of cells (GO:0044319)3.68526620
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.64942449
23apoptotic cell clearance (GO:0043277)3.63945780
24cell-substrate junction assembly (GO:0007044)3.62759865
25regulation of tight junction assembly (GO:2000810)3.62368032
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.61771629
27cell migration involved in sprouting angiogenesis (GO:0002042)3.60043107
28glomerular basement membrane development (GO:0032836)3.58454571
29bone trabecula formation (GO:0060346)3.58253226
30substrate adhesion-dependent cell spreading (GO:0034446)3.47991478
31stress fiber assembly (GO:0043149)3.43297680
32collagen metabolic process (GO:0032963)3.38350584
33* epithelial cell-cell adhesion (GO:0090136)3.36903805
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.36698820
35regulation of transforming growth factor beta2 production (GO:0032909)3.32661853
36collagen catabolic process (GO:0030574)3.28126657
37renal filtration (GO:0097205)3.27762608
38COPI coating of Golgi vesicle (GO:0048205)3.25952701
39Golgi transport vesicle coating (GO:0048200)3.25952701
40regulation of SMAD protein import into nucleus (GO:0060390)3.24875673
41extracellular fibril organization (GO:0043206)3.23061020
42hypotonic response (GO:0006971)3.21324170
43fibroblast migration (GO:0010761)3.20614220
44mesodermal cell differentiation (GO:0048333)3.20134199
45multicellular organismal macromolecule metabolic process (GO:0044259)3.19502947
46insulin-like growth factor receptor signaling pathway (GO:0048009)3.17706748
47extracellular matrix disassembly (GO:0022617)3.16695169
48muscle cell migration (GO:0014812)3.14028529
49negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.11760456
50nuclear pore organization (GO:0006999)3.11386056
51blood vessel endothelial cell migration (GO:0043534)3.11024267
52paraxial mesoderm development (GO:0048339)3.10889162
53mesenchymal-epithelial cell signaling (GO:0060638)3.10058595
54positive regulation of receptor recycling (GO:0001921)3.08774248
55endothelial cell morphogenesis (GO:0001886)3.07911777
56* platelet aggregation (GO:0070527)3.07752618
57protein localization to endosome (GO:0036010)3.07001573
58notochord development (GO:0030903)3.04445928
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.04249021
60regulation of hippo signaling (GO:0035330)3.03773995
61multicellular organismal catabolic process (GO:0044243)3.01975857
62multicellular organismal metabolic process (GO:0044236)3.00863403
63positive regulation of catenin import into nucleus (GO:0035413)2.98810634
64metanephric mesenchyme development (GO:0072075)2.98606612
65cardiac myofibril assembly (GO:0055003)2.97129045
66positive regulation of blood vessel endothelial cell migration (GO:0043536)2.97079453
67cell-substrate adherens junction assembly (GO:0007045)2.96409490
68focal adhesion assembly (GO:0048041)2.96409490
69* adherens junction assembly (GO:0034333)2.96230791
70craniofacial suture morphogenesis (GO:0097094)2.94420965
71positive regulation of epithelial to mesenchymal transition (GO:0010718)2.92680104
72negative regulation of chondrocyte differentiation (GO:0032331)2.92527720
73negative regulation of smooth muscle cell migration (GO:0014912)2.91425392
74positive regulation of SMAD protein import into nucleus (GO:0060391)2.89097114
75negative regulation of fibroblast apoptotic process (GO:2000270)2.88574636
76sarcomere organization (GO:0045214)2.87885570
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.87880866
78cellular response to interferon-alpha (GO:0035457)2.87815869
79kidney mesenchyme development (GO:0072074)2.87254608
80cellular response to vitamin D (GO:0071305)2.85155710
81glomerular filtration (GO:0003094)2.84691713
82cellular response to vitamin (GO:0071295)2.84506335
83glomerular visceral epithelial cell development (GO:0072015)2.84044180
84hemidesmosome assembly (GO:0031581)2.83098023
85positive regulation of osteoblast proliferation (GO:0033690)2.83022005
86polarized epithelial cell differentiation (GO:0030859)2.81851690
87atrioventricular valve morphogenesis (GO:0003181)2.81003208
88branching involved in salivary gland morphogenesis (GO:0060445)2.79797774
89substrate-dependent cell migration (GO:0006929)2.79519257
90positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79196721
91barbed-end actin filament capping (GO:0051016)2.78884433
92fibril organization (GO:0097435)2.78135985
93response to fluid shear stress (GO:0034405)2.76547422
94regulation of cardioblast differentiation (GO:0051890)2.75384067
95positive regulation of macrophage activation (GO:0043032)2.74739346
96regulation of early endosome to late endosome transport (GO:2000641)2.73730719
97cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73075828
98negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69135120
99germ cell migration (GO:0008354)2.69013323
100peptidyl-proline hydroxylation (GO:0019511)2.68641461
101ventricular cardiac muscle cell development (GO:0055015)2.67961550
102regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.67693291
103protein hydroxylation (GO:0018126)2.66941142
104positive regulation of Rho protein signal transduction (GO:0035025)2.66825045
105heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.66556305
106convergent extension (GO:0060026)2.65858710
107regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.65765731
108lymphangiogenesis (GO:0001946)2.64229866
109mRNA transcription (GO:0009299)2.63791752
110regulation of integrin-mediated signaling pathway (GO:2001044)2.62608213
111epoxygenase P450 pathway (GO:0019373)2.62434122
112gap junction assembly (GO:0016264)2.59733723
113dermatan sulfate biosynthetic process (GO:0030208)2.59483251
114extracellular matrix organization (GO:0030198)2.58692173
115* platelet degranulation (GO:0002576)2.58287440
116extracellular structure organization (GO:0043062)2.57944650
117actomyosin structure organization (GO:0031032)2.57784284
118* protein localization to cell surface (GO:0034394)2.57100321
119positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.56625878
120* cell-substrate adhesion (GO:0031589)2.56494228
121heterochromatin organization (GO:0070828)2.56226198
122regulation of cell fate specification (GO:0042659)2.55952835
123atrial septum morphogenesis (GO:0060413)2.55781376
124NLS-bearing protein import into nucleus (GO:0006607)2.55039555
125cellular protein complex localization (GO:0034629)2.54766108
126chondrocyte development (GO:0002063)2.54568250
127pore complex assembly (GO:0046931)2.54304961
128extracellular matrix assembly (GO:0085029)2.52888293
129anterior/posterior axis specification, embryo (GO:0008595)2.52224648
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51884426
131* cell junction assembly (GO:0034329)2.50725838
132* cell-matrix adhesion (GO:0007160)2.50571009
133negative regulation of focal adhesion assembly (GO:0051895)2.50523280
134negative regulation of cell junction assembly (GO:1901889)2.50523280
135negative regulation of adherens junction organization (GO:1903392)2.50523280
136protein complex localization (GO:0031503)2.50513546
137regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50295304
138SMAD protein complex assembly (GO:0007183)2.48732491
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48243483
140regulation of posttranscriptional gene silencing (GO:0060147)2.47220763
141regulation of gene silencing by miRNA (GO:0060964)2.47220763
142regulation of gene silencing by RNA (GO:0060966)2.47220763
143cell migration involved in heart development (GO:0060973)2.46264656
144regulation of integrin activation (GO:0033623)2.45730672
145negative regulation of protein localization to plasma membrane (GO:1903077)2.44326268
146thrombin receptor signaling pathway (GO:0070493)2.42276751
147establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.42230944
148phagocytosis, engulfment (GO:0006911)2.41040680
149cortical actin cytoskeleton organization (GO:0030866)2.40550173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.45274317
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.25350176
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.67107466
4E2F7_22180533_ChIP-Seq_HELA_Human4.18882730
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.61531548
6* CLOCK_20551151_ChIP-Seq_293T_Human3.31387142
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.00591478
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.91116789
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75919093
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.58998523
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56800868
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.50596502
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39169960
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.35706958
15* CJUN_26792858_Chip-Seq_BT549_Human2.32499209
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.30028872
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.28464159
18* BRD4_25478319_ChIP-Seq_HGPS_Human2.18754386
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17646417
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.08595646
21* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06353386
22* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06353386
23PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04235246
24* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.02296956
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01543716
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.98619778
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96348415
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.95641178
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93407435
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.92794248
31* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.78616877
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77940805
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.74272867
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.73741117
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73153354
36ATF3_27146783_Chip-Seq_COLON_Human1.69241485
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66172204
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66172204
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66172204
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64761599
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63961993
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63961993
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61565197
44TP53_16413492_ChIP-PET_HCT116_Human1.61229992
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.60779629
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.60779629
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58871614
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57729253
49ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.50773620
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50625789
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.49951137
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48127427
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46871331
54* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43992031
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43513958
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43162608
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42780906
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.41138135
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40835034
60* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.39649286
61TP53_22127205_ChIP-Seq_IMR90_Human1.38101637
62* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.37690211
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36649458
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.35224790
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32184254
66SOX2_20726797_ChIP-Seq_SW620_Human1.31299011
67* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30939930
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30655062
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30516149
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30216692
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29834792
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29759339
73* RACK7_27058665_Chip-Seq_MCF-7_Human1.27771329
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27392796
75SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27097258
76AR_21909140_ChIP-Seq_LNCAP_Human1.26956007
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25679888
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24702790
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.23438011
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22238763
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21914710
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.21581979
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20955346
84ZNF263_19887448_ChIP-Seq_K562_Human1.19755461
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19208597
86* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18877033
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18695276
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18051182
89* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17517230
90TP53_23651856_ChIP-Seq_MEFs_Mouse1.17429976
91DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17195429
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16215944
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14028542
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13936298
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13908662
96TP53_18474530_ChIP-ChIP_U2OS_Human1.13606063
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.13125014
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12274328
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10634597
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10178200
101* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09267531
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08844440
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08453542
104* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08292765
105* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07827379
106UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05759242
107GATA1_19941826_ChIP-Seq_K562_Human1.05429293
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04364352
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.04274192
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03581029
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.03027141
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02899005
113KDM2B_26808549_Chip-Seq_DND41_Human1.02458271
114* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01834730
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00975687
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99770562
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99692555
118* KLF5_25053715_ChIP-Seq_YYC3_Human0.98032593
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.97585268
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.97518171
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97386962
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97373757
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96354250
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.96021448
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95972817
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95112671
127NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93383641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.51365466
2MP0003705_abnormal_hypodermis_morpholog4.20246968
3MP0005275_abnormal_skin_tensile4.11827338
4MP0003279_aneurysm3.52324095
5MP0005503_abnormal_tendon_morphology3.37027333
6MP0005623_abnormal_meninges_morphology3.25483587
7MP0004272_abnormal_basement_membrane3.17284989
8MP0003566_abnormal_cell_adhesion2.95889201
9MP0010352_gastrointestinal_tract_polyps2.89959957
10MP0001958_emphysema2.78653856
11MP0009384_cardiac_valve_regurgitation2.54515462
12MP0006054_spinal_hemorrhage2.03058161
13MP0005023_abnormal_wound_healing1.98734475
14* MP0003091_abnormal_cell_migration1.91829442
15MP0004084_abnormal_cardiac_muscle1.88283383
16MP0000733_abnormal_muscle_development1.81369874
17MP0010030_abnormal_orbit_morphology1.81185277
18MP0005464_abnormal_platelet_physiology1.71769395
19MP0000767_abnormal_smooth_muscle1.65656950
20MP0005508_abnormal_skeleton_morphology1.63308614
21MP0002295_abnormal_pulmonary_circulatio1.58669368
22MP0002060_abnormal_skin_morphology1.58205196
23MP0009053_abnormal_anal_canal1.56122939
24MP0003385_abnormal_body_wall1.52246809
25MP0005257_abnormal_intraocular_pressure1.49926243
26MP0000750_abnormal_muscle_regeneration1.48436557
27MP0010368_abnormal_lymphatic_system1.47401072
28MP0000751_myopathy1.45824683
29MP0002877_abnormal_melanocyte_morpholog1.43281115
30MP0003045_fibrosis1.41169619
31MP0002254_reproductive_system_inflammat1.37044059
32MP0005076_abnormal_cell_differentiation1.34770300
33MP0008004_abnormal_stomach_pH1.33063079
34MP0006138_congestive_heart_failure1.29701072
35MP0002896_abnormal_bone_mineralization1.29048998
36MP0003300_gastrointestinal_ulcer1.28087182
37MP0001299_abnormal_eye_distance/1.27962971
38MP0003950_abnormal_plasma_membrane1.27736502
39MP0002108_abnormal_muscle_morphology1.24867412
40MP0000537_abnormal_urethra_morphology1.24709030
41MP0000013_abnormal_adipose_tissue1.24638984
42MP0003941_abnormal_skin_development1.24299157
43MP0001243_abnormal_dermal_layer1.23314126
44* MP0004087_abnormal_muscle_fiber1.23264576
45MP0009250_abnormal_appendicular_skeleto1.22451723
46MP0001348_abnormal_lacrimal_gland1.14372617
47MP0000762_abnormal_tongue_morphology1.13622101
48MP0005330_cardiomyopathy1.13284407
49MP0000749_muscle_degeneration1.13227880
50MP0004957_abnormal_blastocyst_morpholog1.13058855
51* MP0010630_abnormal_cardiac_muscle1.12449352
52MP0003115_abnormal_respiratory_system1.12288226
53MP0002168_other_aberrant_phenotype1.10745745
54MP0001661_extended_life_span1.10546510
55MP0000428_abnormal_craniofacial_morphol1.10231882
56MP0002128_abnormal_blood_circulation1.09700997
57MP0000534_abnormal_ureter_morphology1.06658838
58MP0002282_abnormal_trachea_morphology1.05828554
59* MP0001730_embryonic_growth_arrest1.04129710
60MP0003942_abnormal_urinary_system1.03517164
61MP0001542_abnormal_bone_strength1.02785089
62MP0001879_abnormal_lymphatic_vessel1.01839756
63* MP0001614_abnormal_blood_vessel1.00194577
64* MP0002925_abnormal_cardiovascular_devel1.00193357
65MP0008775_abnormal_heart_ventricle0.98626479
66MP0005409_darkened_coat_color0.97845762
67MP0003828_pulmonary_edema0.96194282
68MP0000858_altered_metastatic_potential0.95058306
69MP0000003_abnormal_adipose_tissue0.94975532
70MP0003283_abnormal_digestive_organ0.94908766
71* MP0002085_abnormal_embryonic_tissue0.94440576
72MP0009697_abnormal_copulation0.94244053
73* MP0008932_abnormal_embryonic_tissue0.94207853
74MP0004510_myositis0.93858312
75* MP0002084_abnormal_developmental_patter0.93526108
76* MP0003984_embryonic_growth_retardation0.93058145
77* MP0001672_abnormal_embryogenesis/_devel0.92805367
78* MP0005380_embryogenesis_phenotype0.92805367
79MP0009672_abnormal_birth_weight0.92621597
80MP0005501_abnormal_skin_physiology0.92559518
81MP0002837_dystrophic_cardiac_calcinosis0.92345673
82MP0005595_abnormal_vascular_smooth0.92165992
83MP0004858_abnormal_nervous_system0.91747896
84MP0004233_abnormal_muscle_weight0.91464466
85MP0000163_abnormal_cartilage_morphology0.91203778
86MP0004036_abnormal_muscle_relaxation0.90748592
87MP0005390_skeleton_phenotype0.89789887
88MP0001915_intracranial_hemorrhage0.88961086
89MP0002932_abnormal_joint_morphology0.88783888
90MP0001544_abnormal_cardiovascular_syste0.87819380
91MP0005385_cardiovascular_system_phenoty0.87819380
92MP0002115_abnormal_skeleton_extremities0.87655216
93MP0003755_abnormal_palate_morphology0.87527167
94* MP0005621_abnormal_cell_physiology0.86836658
95* MP0002088_abnormal_embryonic_growth/wei0.86674674
96MP0000579_abnormal_nail_morphology0.86311870
97MP0003111_abnormal_nucleus_morphology0.86197831
98MP0000759_abnormal_skeletal_muscle0.86028126
99MP0004197_abnormal_fetal_growth/weight/0.84794611
100MP0003453_abnormal_keratinocyte_physiol0.84066762
101MP0002113_abnormal_skeleton_development0.83250524
102* MP0003935_abnormal_craniofacial_develop0.82470192
103MP0002796_impaired_skin_barrier0.80458267
104* MP0000266_abnormal_heart_morphology0.80393585
105* MP0002972_abnormal_cardiac_muscle0.80018173
106MP0000516_abnormal_urinary_system0.79473774
107MP0005367_renal/urinary_system_phenotyp0.79473774
108MP0005165_increased_susceptibility_to0.79387331
109* MP0002080_prenatal_lethality0.79315717
110MP0000350_abnormal_cell_proliferation0.78941453
111MP0004134_abnormal_chest_morphology0.78240512
112MP0000467_abnormal_esophagus_morphology0.77673080
113MP0002697_abnormal_eye_size0.77620111
114MP0004185_abnormal_adipocyte_glucose0.77518003
115MP0005197_abnormal_uvea_morphology0.77321613
116MP0002269_muscular_atrophy0.76968331
117MP0005375_adipose_tissue_phenotype0.76287671
118* MP0000432_abnormal_head_morphology0.75915685
119* MP0005620_abnormal_muscle_contractility0.75796310
120MP0009780_abnormal_chondrocyte_physiolo0.74792351
121MP0009278_abnormal_bone_marrow0.73525162
122MP0001849_ear_inflammation0.72347769
123MP0001175_abnormal_lung_morphology0.71353514
124* MP0003937_abnormal_limbs/digits/tail_de0.69770771
125MP0003567_abnormal_fetal_cardiomyocyte0.69390040
126MP0002089_abnormal_postnatal_growth/wei0.69084458
127MP0002086_abnormal_extraembryonic_tissu0.68902678
128MP0003448_altered_tumor_morphology0.68601737
129MP0000747_muscle_weakness0.68349734
130MP0005369_muscle_phenotype0.66886621
131MP0002933_joint_inflammation0.66807335
132MP0005193_abnormal_anterior_eye0.66755014

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.84603046
2Protrusio acetabuli (HP:0003179)6.77814918
3Aortic dissection (HP:0002647)4.67419188
4Ankle contracture (HP:0006466)4.62180932
5Shallow orbits (HP:0000586)4.47529657
6Cerebral aneurysm (HP:0004944)4.13309093
7Aortic aneurysm (HP:0004942)4.13202380
8Peritonitis (HP:0002586)4.03000350
9Atrophic scars (HP:0001075)4.02298038
10Abnormal platelet volume (HP:0011876)3.93935551
11Cervical subluxation (HP:0003308)3.75639066
12Dilatation of the ascending aorta (HP:0005111)3.62796314
13Broad metatarsal (HP:0001783)3.49219548
14Increased connective tissue (HP:0009025)3.48795110
15Soft skin (HP:0000977)3.47029250
16Bladder diverticulum (HP:0000015)3.38004627
17Fragile skin (HP:0001030)3.34436659
18Type 1 muscle fiber predominance (HP:0003803)3.26926821
19Abnormality of dentin (HP:0010299)3.20193411
20Mitral valve prolapse (HP:0001634)3.18766221
21Spinal rigidity (HP:0003306)3.14023297
22Menorrhagia (HP:0000132)3.12590717
23Wrist flexion contracture (HP:0001239)3.02571080
24Genu recurvatum (HP:0002816)2.95100994
25Wormian bones (HP:0002645)2.94302616
26Neonatal short-limb short stature (HP:0008921)2.84845734
27Blue sclerae (HP:0000592)2.79696208
28Right ventricular cardiomyopathy (HP:0011663)2.78871615
29Aneurysm (HP:0002617)2.66538197
30Osteolytic defects of the hand bones (HP:0009699)2.64527370
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.64527370
32Short nail (HP:0001799)2.60548381
33Increased density of long bones (HP:0006392)2.55304973
34Bowel diverticulosis (HP:0005222)2.54560887
35Mildly elevated creatine phosphokinase (HP:0008180)2.51843153
36Abnormality of the calcaneus (HP:0008364)2.51727423
37Muscle fiber splitting (HP:0003555)2.51542436
38Scapular winging (HP:0003691)2.51003050
39Radial bowing (HP:0002986)2.48782671
40Vascular tortuosity (HP:0004948)2.46244927
41Increased variability in muscle fiber diameter (HP:0003557)2.45535839
42Difficulty climbing stairs (HP:0003551)2.45212424
43Camptodactyly of toe (HP:0001836)2.43868962
44Biconcave vertebral bodies (HP:0004586)2.42811118
45Follicular hyperkeratosis (HP:0007502)2.40284460
46Lower limb amyotrophy (HP:0007210)2.39808604
47Short 4th metacarpal (HP:0010044)2.37978627
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37978627
49Ulnar bowing (HP:0003031)2.36781144
50Mesomelia (HP:0003027)2.31076728
51Vertebral compression fractures (HP:0002953)2.30814333
52Distal upper limb amyotrophy (HP:0007149)2.30647204
53Upper limb amyotrophy (HP:0009129)2.30647204
54Hyporeflexia of lower limbs (HP:0002600)2.28785289
55Disproportionate tall stature (HP:0001519)2.27424038
56Elbow flexion contracture (HP:0002987)2.26714585
57Infantile muscular hypotonia (HP:0008947)2.26328076
58Tibial bowing (HP:0002982)2.26069866
59Abnormality of skeletal muscle fiber size (HP:0012084)2.24867041
60Abnormality of the acetabulum (HP:0003170)2.23776664
61Round ear (HP:0100830)2.20093028
62Abnormal delivery (HP:0001787)2.20049057
63Broad face (HP:0000283)2.19028687
64Hyperextensible skin (HP:0000974)2.18434900
65Abnormality of oral frenula (HP:0000190)2.12399788
66Bowing of the arm (HP:0006488)2.11828887
67Bowed forearm bones (HP:0003956)2.11828887
68Abnormality of the peritoneum (HP:0002585)2.11278810
69Prolonged bleeding time (HP:0003010)2.09700348
70Spinal cord lesions (HP:0100561)2.09646057
71Syringomyelia (HP:0003396)2.09646057
72Thin bony cortex (HP:0002753)2.08398430
73Knee flexion contracture (HP:0006380)2.08088404
74Distal lower limb muscle weakness (HP:0009053)2.07478826
75Deviation of the hallux (HP:0010051)2.07424772
76Mitral regurgitation (HP:0001653)2.04965361
77Overgrowth (HP:0001548)2.04168392
78Ectopia lentis (HP:0001083)2.04112459
79Buphthalmos (HP:0000557)2.03998469
80Arterial tortuosity (HP:0005116)2.03575263
81Hallux valgus (HP:0001822)2.01054049
82Fused cervical vertebrae (HP:0002949)2.00507719
83Distal lower limb amyotrophy (HP:0008944)1.99656036
84Slender build (HP:0001533)1.99333005
85Abnormality of the 4th metacarpal (HP:0010012)1.99300118
86Wide anterior fontanel (HP:0000260)1.99224101
87Joint laxity (HP:0001388)1.99142211
88Nemaline bodies (HP:0003798)1.98968412
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.97720441
90Ankyloglossia (HP:0010296)1.96586399
91Joint contractures involving the joints of the feet (HP:0100492)1.92551327
92Flexion contracture of toe (HP:0005830)1.92551327
93Selective tooth agenesis (HP:0001592)1.90372162
94Increased mean platelet volume (HP:0011877)1.89540418
95Tarsal synostosis (HP:0008368)1.87912812
96Broad long bones (HP:0005622)1.86006727
97Absent frontal sinuses (HP:0002688)1.85083244
98Aortic regurgitation (HP:0001659)1.81922737
99Natal tooth (HP:0000695)1.81200676
100Short hallux (HP:0010109)1.80817512
101Bell-shaped thorax (HP:0001591)1.80055548
102Broad ribs (HP:0000885)1.76668689
103Muscle fiber inclusion bodies (HP:0100299)1.75146886
104Myocardial infarction (HP:0001658)1.74796864
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.74738242
106Back pain (HP:0003418)1.74676903
107Persistence of primary teeth (HP:0006335)1.73839585
108Coronal craniosynostosis (HP:0004440)1.73789962
109Hip contracture (HP:0003273)1.73493561
110Vertebral arch anomaly (HP:0008438)1.73055482
111Venous abnormality (HP:0002624)1.71729186
112Femoral bowing (HP:0002980)1.71058651
113Hand muscle atrophy (HP:0009130)1.70887682
114Delayed cranial suture closure (HP:0000270)1.70722778
115Breech presentation (HP:0001623)1.70579084
116Relative macrocephaly (HP:0004482)1.69943953
117Hyperacusis (HP:0010780)1.69115589
118Spondylolisthesis (HP:0003302)1.69021641
119Mitral stenosis (HP:0001718)1.68909696
120Difficulty running (HP:0009046)1.68593486
121Spastic diplegia (HP:0001264)1.63609370
122Abnormality of the umbilical cord (HP:0010881)1.61484351
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.61291550
124Achilles tendon contracture (HP:0001771)1.60987342
125Aortic valve stenosis (HP:0001650)1.60917090
126Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60045880
127Petechiae (HP:0000967)1.59290226
128Limb-girdle muscle weakness (HP:0003325)1.58909462
129Arnold-Chiari malformation (HP:0002308)1.58691609
130Generalized amyotrophy (HP:0003700)1.57493075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.67000527
2TRIB33.93949835
3DDR23.39884898
4LATS13.17701169
5PDGFRA2.91179012
6PKN22.79459426
7EPHA22.43636668
8RIPK12.26114233
9DMPK2.21065736
10PAK22.09690860
11TRPM72.04395749
12LATS22.00068665
13SIK11.93385816
14ERN11.82598155
15PTK21.78247260
16MYLK1.77708911
17EPHB21.73777123
18PTK61.63248478
19BMX1.63098250
20EIF2AK11.62829893
21SMG11.61262065
22CDK121.59589454
23LRRK21.59375496
24PAK31.53765830
25STK31.48710016
26PIK3CA1.47243303
27EEF2K1.46228813
28FER1.44590981
29TESK11.44146060
30TTK1.41375018
31PAK41.38568118
32MET1.30243466
33TGFBR21.29634854
34MTOR1.24552778
35PTK2B1.21750949
36LIMK11.19850527
37BRSK21.18362438
38ILK1.16431435
39STK101.13845438
40STK38L1.12770980
41PDGFRB1.12545127
42EPHB11.12238272
43ROCK11.11625632
44MST41.10120504
45FGFR11.08466189
46EPHA31.07457495
47MAP3K101.05791455
48FRK1.04217307
49TSSK61.01193824
50CAMK1D0.99331654
51MOS0.94679180
52STK240.89015038
53LMTK20.87937197
54NUAK10.86101248
55STK40.84865841
56NEK90.84303701
57CDC70.82558298
58MELK0.81400369
59PIK3CG0.81257506
60STK380.81227932
61PLK30.77368359
62TGFBR10.76092318
63RPS6KA40.75084216
64FLT30.73995436
65CDK60.73856174
66ERBB30.71750358
67RPS6KB20.71448386
68SCYL20.70969529
69PNCK0.70724058
70MAP3K30.70318672
71ROCK20.69097926
72MAP3K60.68469817
73MAP2K10.68195979
74CDC42BPA0.68043259
75MAP2K30.67631032
76MAP3K80.65285310
77MAPKAPK30.65155722
78KDR0.64497784
79PRKG20.61116347
80KSR20.60230054
81ZAK0.60217378
82BUB10.60077954
83PDK40.58261059
84PDK30.58261059
85INSR0.58207107
86KSR10.58173234
87RET0.57980842
88FGFR20.57904188
89NEK10.57854515
90TIE10.57196654
91CLK10.56947842
92PRKD10.53483324
93PAK10.52340183
94CAMK1G0.51677754
95GSK3A0.51354064
96CDK80.50715771
97PDK20.48206274
98TAF10.43807677
99NEK20.43262158
100FGFR30.42352102
101YES10.41138312
102PBK0.40322351
103CDK90.40162654
104MST1R0.40082108
105TAOK20.39959554
106TEC0.38327128
107RAF10.37209305
108ICK0.37049555
109FGFR40.36809862
110CDK70.36338015
111AKT30.35256159
112DAPK30.34770239
113CHEK20.34730212
114ZAP700.34367231
115NTRK10.34236805
116PRKD30.32520315
117ERBB40.31562416
118* SRC0.31341988
119JAK10.30987898
120PRKD20.28008137
121MAPKAPK20.27592488
122EGFR0.27079419
123CHEK10.26898966
124ALK0.26879054
125AURKB0.26719155
126RPS6KA20.25721509
127AKT20.24418608
128WNK10.24269791
129ABL20.24015733
130OBSCN0.23606053
131PIM20.23553991
132MAPK10.23516299
133PRKCH0.23469356

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.17128570
2* Focal adhesion_Homo sapiens_hsa045103.25191514
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.79989385
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.75062176
5Dilated cardiomyopathy_Homo sapiens_hsa054142.65995432
6Proteoglycans in cancer_Homo sapiens_hsa052052.60289165
7* Adherens junction_Homo sapiens_hsa045202.47865408
8Small cell lung cancer_Homo sapiens_hsa052222.36876533
9* Amoebiasis_Homo sapiens_hsa051462.16999753
10* Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.16494284
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.08688444
12Bladder cancer_Homo sapiens_hsa052192.05125063
13TGF-beta signaling pathway_Homo sapiens_hsa043502.02887598
14Hippo signaling pathway_Homo sapiens_hsa043902.00416048
15MicroRNAs in cancer_Homo sapiens_hsa052061.93972583
16Protein digestion and absorption_Homo sapiens_hsa049741.78876656
17Viral myocarditis_Homo sapiens_hsa054161.73565772
18Tight junction_Homo sapiens_hsa045301.70334455
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68483394
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66008228
21* Leukocyte transendothelial migration_Homo sapiens_hsa046701.62563384
22* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.59457114
23Chronic myeloid leukemia_Homo sapiens_hsa052201.56496482
24Malaria_Homo sapiens_hsa051441.53556551
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44887860
26Basal cell carcinoma_Homo sapiens_hsa052171.40726951
27p53 signaling pathway_Homo sapiens_hsa041151.39561183
28Platelet activation_Homo sapiens_hsa046111.22367856
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21892714
30Melanoma_Homo sapiens_hsa052181.19572741
31Toxoplasmosis_Homo sapiens_hsa051451.19003994
32Pathways in cancer_Homo sapiens_hsa052001.11295209
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10932751
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10707029
35Pancreatic cancer_Homo sapiens_hsa052121.08769086
36Rap1 signaling pathway_Homo sapiens_hsa040151.08219608
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.06451651
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06418401
39Pentose phosphate pathway_Homo sapiens_hsa000301.06002084
40Salmonella infection_Homo sapiens_hsa051321.05431708
41Hedgehog signaling pathway_Homo sapiens_hsa043401.04189645
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00769083
43* Shigellosis_Homo sapiens_hsa051310.98298149
44Prostate cancer_Homo sapiens_hsa052150.96436388
45HIF-1 signaling pathway_Homo sapiens_hsa040660.95914504
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95698002
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94288423
48HTLV-I infection_Homo sapiens_hsa051660.92857039
49Glioma_Homo sapiens_hsa052140.88007120
50TNF signaling pathway_Homo sapiens_hsa046680.85210433
51Viral carcinogenesis_Homo sapiens_hsa052030.83063954
52Insulin resistance_Homo sapiens_hsa049310.82350615
53Biosynthesis of amino acids_Homo sapiens_hsa012300.82312679
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82249223
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81012516
56Galactose metabolism_Homo sapiens_hsa000520.79561149
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.79470965
58mTOR signaling pathway_Homo sapiens_hsa041500.79418642
59Renal cell carcinoma_Homo sapiens_hsa052110.78945267
60Endometrial cancer_Homo sapiens_hsa052130.74431755
61Leishmaniasis_Homo sapiens_hsa051400.74288544
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73527530
63Apoptosis_Homo sapiens_hsa042100.72789485
64Axon guidance_Homo sapiens_hsa043600.72695255
65Notch signaling pathway_Homo sapiens_hsa043300.70659083
66Colorectal cancer_Homo sapiens_hsa052100.69801363
67AMPK signaling pathway_Homo sapiens_hsa041520.69770218
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69204685
69Wnt signaling pathway_Homo sapiens_hsa043100.67569525
70ErbB signaling pathway_Homo sapiens_hsa040120.67425354
71Lysine degradation_Homo sapiens_hsa003100.66465571
72VEGF signaling pathway_Homo sapiens_hsa043700.65746131
73FoxO signaling pathway_Homo sapiens_hsa040680.64920123
74Mismatch repair_Homo sapiens_hsa034300.64568517
75Ovarian steroidogenesis_Homo sapiens_hsa049130.63156774
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.62318359
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60908616
78Hepatitis B_Homo sapiens_hsa051610.60640379
79Renin-angiotensin system_Homo sapiens_hsa046140.60120108
80Fatty acid biosynthesis_Homo sapiens_hsa000610.58861446
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57457628
82DNA replication_Homo sapiens_hsa030300.54965401
83Insulin signaling pathway_Homo sapiens_hsa049100.54965222
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.54860814
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54774687
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54525912
87Choline metabolism in cancer_Homo sapiens_hsa052310.54382896
88Phagosome_Homo sapiens_hsa041450.54049171
89Dorso-ventral axis formation_Homo sapiens_hsa043200.53834467
90PPAR signaling pathway_Homo sapiens_hsa033200.53520939
91Melanogenesis_Homo sapiens_hsa049160.50996810
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50886178
93Cell cycle_Homo sapiens_hsa041100.50724715
94Estrogen signaling pathway_Homo sapiens_hsa049150.50515417
95Steroid biosynthesis_Homo sapiens_hsa001000.50145791
96Thyroid cancer_Homo sapiens_hsa052160.49646582
97Gap junction_Homo sapiens_hsa045400.48086729
98Endocytosis_Homo sapiens_hsa041440.47907907
99N-Glycan biosynthesis_Homo sapiens_hsa005100.47306740
100Selenocompound metabolism_Homo sapiens_hsa004500.45923156
101Ras signaling pathway_Homo sapiens_hsa040140.43472391
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43200605
103Inositol phosphate metabolism_Homo sapiens_hsa005620.42497603
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.42141587
105Non-homologous end-joining_Homo sapiens_hsa034500.41360367
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.41232717
107One carbon pool by folate_Homo sapiens_hsa006700.41184022
108mRNA surveillance pathway_Homo sapiens_hsa030150.41142720
109Carbon metabolism_Homo sapiens_hsa012000.40987463
110RNA transport_Homo sapiens_hsa030130.40561667
111Non-small cell lung cancer_Homo sapiens_hsa052230.40243078
112Fatty acid metabolism_Homo sapiens_hsa012120.39377329
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39109192
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38418793
115Thyroid hormone synthesis_Homo sapiens_hsa049180.38313118
116Pertussis_Homo sapiens_hsa051330.38019598
117Nucleotide excision repair_Homo sapiens_hsa034200.37317412
118MAPK signaling pathway_Homo sapiens_hsa040100.37293414
119Acute myeloid leukemia_Homo sapiens_hsa052210.37215014
120Osteoclast differentiation_Homo sapiens_hsa043800.34941361
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34839220
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34220602
123Glucagon signaling pathway_Homo sapiens_hsa049220.34111024
124Fatty acid degradation_Homo sapiens_hsa000710.33885492

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