VCX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)7.62244442
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)7.50270895
3chromosome condensation (GO:0030261)7.39467146
4DNA packaging (GO:0006323)7.20987592
5acrosome reaction (GO:0007340)7.16806510
6sperm motility (GO:0030317)6.67611795
7regulation of retinoic acid receptor signaling pathway (GO:0048385)6.34442745
8male meiosis I (GO:0007141)6.21940429
9binding of sperm to zona pellucida (GO:0007339)5.97672879
10rRNA methylation (GO:0031167)5.94734238
11spermatid development (GO:0007286)5.79464509
12sperm capacitation (GO:0048240)5.79236012
13microtubule depolymerization (GO:0007019)5.71430251
14spermatid nucleus differentiation (GO:0007289)5.65740272
15plasma membrane fusion (GO:0045026)5.63606558
16rRNA modification (GO:0000154)5.62571975
17sperm-egg recognition (GO:0035036)5.57453133
18DNA methylation involved in gamete generation (GO:0043046)5.16909071
19oxygen transport (GO:0015671)5.10699069
20meiosis I (GO:0007127)5.03441913
21gas transport (GO:0015669)4.87995913
22male meiosis (GO:0007140)4.87556818
23response to pheromone (GO:0019236)4.82293680
24histone H3-K9 demethylation (GO:0033169)4.81079746
25synapsis (GO:0007129)4.69572203
26microtubule polymerization or depolymerization (GO:0031109)4.54684001
27cell-cell recognition (GO:0009988)4.44183350
28piRNA metabolic process (GO:0034587)4.43820005
29negative regulation of inclusion body assembly (GO:0090084)4.40594909
30chromosome organization involved in meiosis (GO:0070192)4.30864502
31calcium ion-dependent exocytosis (GO:0017156)4.29070090
32* spermatogenesis (GO:0007283)4.25850110
33* male gamete generation (GO:0048232)4.25310419
34multicellular organism reproduction (GO:0032504)4.16595168
35single strand break repair (GO:0000012)4.15401225
36synaptonemal complex assembly (GO:0007130)4.12321103
37sexual reproduction (GO:0019953)4.08299436
38meiotic nuclear division (GO:0007126)4.07838275
39reproduction (GO:0000003)3.98623915
40* gamete generation (GO:0007276)3.96767109
41nuclear pore complex assembly (GO:0051292)3.91553320
42urinary tract smooth muscle contraction (GO:0014848)3.91536708
43centriole replication (GO:0007099)3.85532507
44centriole assembly (GO:0098534)3.80151376
45nucleosome disassembly (GO:0006337)3.70136860
46protein-DNA complex disassembly (GO:0032986)3.70136860
47regulation of histone H3-K27 methylation (GO:0061085)3.66067930
48regulation of centriole replication (GO:0046599)3.65375310
49motile cilium assembly (GO:0044458)3.61115243
50synaptonemal complex organization (GO:0070193)3.56486158
51phosphatidylethanolamine biosynthetic process (GO:0006646)3.54942527
52resolution of meiotic recombination intermediates (GO:0000712)3.51278619
53polyamine biosynthetic process (GO:0006596)3.50981463
54regulation of cilium movement (GO:0003352)3.50349761
55regulation of microtubule-based movement (GO:0060632)3.50341697
56protein polyglutamylation (GO:0018095)3.42675693
57microtubule severing (GO:0051013)3.41275919
58germ cell development (GO:0007281)3.40033390
59meiotic cell cycle process (GO:1903046)3.39019948
60nuclear pore organization (GO:0006999)3.37101117
61regulation of inclusion body assembly (GO:0090083)3.36810365
62proline biosynthetic process (GO:0006561)3.34570648
63nucleus organization (GO:0006997)3.31668351
64short-chain fatty acid metabolic process (GO:0046459)3.25979527
65negative regulation of gene silencing (GO:0060969)3.24639845
66muscle organ morphogenesis (GO:0048644)3.22671289
67cellular process involved in reproduction in multicellular organism (GO:0022412)3.21962728
68* multicellular organismal reproductive process (GO:0048609)3.17553217
69phosphatidylethanolamine metabolic process (GO:0046337)3.16116154
70chaperone-mediated protein complex assembly (GO:0051131)3.10370299
71DNA conformation change (GO:0071103)3.08666544
72cellular ketone body metabolic process (GO:0046950)3.05548433
73DNA synthesis involved in DNA repair (GO:0000731)3.04343160
74regulation of histone H3-K4 methylation (GO:0051569)3.03372305
75axonemal dynein complex assembly (GO:0070286)3.02742885
76cell wall macromolecule catabolic process (GO:0016998)3.01797818
77chromatin silencing (GO:0006342)3.00734484
78RNA methylation (GO:0001510)2.96244175
79mitotic chromosome condensation (GO:0007076)2.96119293
80regulation of somitogenesis (GO:0014807)2.94970153
81regulation of RNA export from nucleus (GO:0046831)2.93588145
82autophagic vacuole fusion (GO:0000046)2.92908710
83fertilization (GO:0009566)2.85895231
84histone exchange (GO:0043486)2.85249332
85negative regulation of histone methylation (GO:0031061)2.84237101
86somite rostral/caudal axis specification (GO:0032525)2.83068030
87histone H4 deacetylation (GO:0070933)2.80046582
88protein targeting to Golgi (GO:0000042)2.78207824
89regulation of histone H3-K9 methylation (GO:0051570)2.77341866
90pore complex assembly (GO:0046931)2.76446534
91negative regulation of Notch signaling pathway (GO:0045746)2.74019134
92peristalsis (GO:0030432)2.73090688
93response to food (GO:0032094)2.71839408
94positive regulation of gene expression, epigenetic (GO:0045815)2.66833295
95face development (GO:0060324)2.66141054
96response to dietary excess (GO:0002021)2.65861945
97cell wall macromolecule metabolic process (GO:0044036)2.65584118
98ketone body metabolic process (GO:1902224)2.65455342
99regulation of histone methylation (GO:0031060)2.63947265
100regulation of translational fidelity (GO:0006450)2.63670297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.76924591
2E2F7_22180533_ChIP-Seq_HELA_Human3.62464165
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.04206663
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52487830
5POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.44384350
6ZNF263_19887448_ChIP-Seq_K562_Human2.15400850
7P68_20966046_ChIP-Seq_HELA_Human2.13132216
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.12753710
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.12731854
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00326551
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00204167
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97765375
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.93085176
14SMC4_20622854_ChIP-Seq_HELA_Human1.92921281
15NCOR1_26117541_ChIP-Seq_K562_Human1.91365040
16FOXM1_23109430_ChIP-Seq_U2OS_Human1.90752759
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90183533
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87173256
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83585227
20YY1_22570637_ChIP-Seq_MALME-3M_Human1.80593841
21XRN2_22483619_ChIP-Seq_HELA_Human1.74105728
22LXR_22292898_ChIP-Seq_THP-1_Human1.73077092
23E2F1_20622854_ChIP-Seq_HELA_Human1.72480263
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69764983
25BCOR_27268052_Chip-Seq_Bcells_Human1.65736057
26ERA_21632823_ChIP-Seq_H3396_Human1.65478927
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62855453
28AR_21909140_ChIP-Seq_LNCAP_Human1.62611087
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62453917
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.61173175
31RAC3_21632823_ChIP-Seq_H3396_Human1.56851814
32PHF8_20622854_ChIP-Seq_HELA_Human1.56106552
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56090878
34BCL6_27268052_Chip-Seq_Bcells_Human1.55994121
35KDM5A_27292631_Chip-Seq_BREAST_Human1.53391649
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53282104
37CTCF_20526341_ChIP-Seq_ESCs_Human1.52918927
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.51921095
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.51143824
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50747153
41GABP_19822575_ChIP-Seq_HepG2_Human1.50690130
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45775433
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45685269
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42981043
45CTCF_27219007_Chip-Seq_Bcells_Human1.42647656
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40150786
47CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.39666156
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38503544
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.38411754
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36784680
51TTF2_22483619_ChIP-Seq_HELA_Human1.36098222
52FOXP1_21924763_ChIP-Seq_HESCs_Human1.35352105
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34451377
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34296160
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33934267
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32219963
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.30568848
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28723544
59RUNX1_27514584_Chip-Seq_MCF-7_Human1.28540118
60P300_27268052_Chip-Seq_Bcells_Human1.26485353
61NANOG_20526341_ChIP-Seq_ESCs_Human1.26027088
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25180890
63TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24756287
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23161796
65CTCF_21964334_Chip-Seq_Bcells_Human1.22826030
66RARA_24833708_ChIP-Seq_LIVER_Mouse1.22281576
67GATA1_19941826_ChIP-Seq_K562_Human1.19851417
68TP63_22573176_ChIP-Seq_HFKS_Human1.19442587
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18470787
70P53_21459846_ChIP-Seq_SAOS-2_Human1.17707003
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17288719
72SA1_27219007_Chip-Seq_Bcells_Human1.15845506
73RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15636352
74ELF5_23300383_ChIP-Seq_T47D_Human1.15329687
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15123836
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14790455
77SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14682173
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13634046
79RACK7_27058665_Chip-Seq_MCF-7_Human1.13382843
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09708064
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09079059
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07390529
83DCP1A_22483619_ChIP-Seq_HELA_Human1.05969938
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05348525
85FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04858033
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04429301
87STAT1_20625510_ChIP-Seq_HELA_Human1.02947909
88MYC_19829295_ChIP-Seq_ESCs_Human1.01546245
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.00198786
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99618402
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99237261
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97803443
93OCT4_20526341_ChIP-Seq_ESCs_Human0.97056627
94ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96871738
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96750284
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96031327
97TAF2_19829295_ChIP-Seq_ESCs_Human0.95059652
98HOXB7_26014856_ChIP-Seq_BT474_Human0.94846359
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94657187
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92852646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.96917024
2MP0005377_hearing/vestibular/ear_phenot3.74239001
3MP0003878_abnormal_ear_physiology3.74239001
4MP0003698_abnormal_male_reproductive3.64122238
5MP0001929_abnormal_gametogenesis3.54264056
6MP0000678_abnormal_parathyroid_gland3.39510631
7MP0010234_abnormal_vibrissa_follicle3.06043210
8MP0003718_maternal_effect2.83806601
9MP0002210_abnormal_sex_determination2.66764637
10MP0003693_abnormal_embryo_hatching2.63358772
11MP0008995_early_reproductive_senescence2.44786336
12MP0004957_abnormal_blastocyst_morpholog2.24855784
13MP0005083_abnormal_biliary_tract2.24282676
14MP0002161_abnormal_fertility/fecundity2.21395201
15MP0000372_irregular_coat_pigmentation2.14644424
16MP0004233_abnormal_muscle_weight2.09636460
17MP0001145_abnormal_male_reproductive2.03613992
18MP0008877_abnormal_DNA_methylation2.00056612
19MP0001348_abnormal_lacrimal_gland1.99345397
20MP0008058_abnormal_DNA_repair1.94186717
21MP0005670_abnormal_white_adipose1.94149911
22MP0005451_abnormal_body_composition1.93529304
23MP0003077_abnormal_cell_cycle1.91606679
24MP0000653_abnormal_sex_gland1.89052589
25MP0002132_abnormal_respiratory_system1.78950903
26MP0005310_abnormal_salivary_gland1.71795670
27MP0002796_impaired_skin_barrier1.71101750
28MP0003123_paternal_imprinting1.62324218
29MP0004147_increased_porphyrin_level1.60713957
30MP0002249_abnormal_larynx_morphology1.55267385
31MP0003111_abnormal_nucleus_morphology1.55153093
32MP0003786_premature_aging1.50452244
33MP0001188_hyperpigmentation1.42885243
34MP0000681_abnormal_thyroid_gland1.38346850
35MP0005423_abnormal_somatic_nervous1.35512279
36MP0010094_abnormal_chromosome_stability1.34296965
37MP0009697_abnormal_copulation1.26815294
38MP0003646_muscle_fatigue1.25298110
39MP0004264_abnormal_extraembryonic_tissu1.19466320
40MP0005395_other_phenotype1.17331231
41MP0003699_abnormal_female_reproductive1.17075068
42MP0003936_abnormal_reproductive_system1.14013876
43MP0003136_yellow_coat_color1.13121665
44MP0006036_abnormal_mitochondrial_physio1.11975682
45MP0001545_abnormal_hematopoietic_system1.09273181
46MP0005397_hematopoietic_system_phenotyp1.09273181
47MP0005636_abnormal_mineral_homeostasis1.09147830
48MP0003011_delayed_dark_adaptation1.06733628
49MP0004885_abnormal_endolymph1.06394251
50MP0005408_hypopigmentation1.05802756
51MP0001672_abnormal_embryogenesis/_devel1.05148687
52MP0005380_embryogenesis_phenotype1.05148687
53MP0001666_abnormal_nutrient_absorption1.04951097
54MP0002234_abnormal_pharynx_morphology1.04707864
55MP0001881_abnormal_mammary_gland1.02353332
56MP0008932_abnormal_embryonic_tissue1.00677299
57MP0005058_abnormal_lysosome_morphology0.99831667
58MP0004019_abnormal_vitamin_homeostasis0.98133247
59MP0008057_abnormal_DNA_replication0.97600419
60MP0002160_abnormal_reproductive_system0.96189189
61MP0004381_abnormal_hair_follicle0.94431182
62MP0000350_abnormal_cell_proliferation0.94141269
63MP0006035_abnormal_mitochondrial_morpho0.93748053
64MP0000313_abnormal_cell_death0.93293986
65MP0001765_abnormal_ion_homeostasis0.91239939
66MP0002080_prenatal_lethality0.90846054
67MP0001730_embryonic_growth_arrest0.89364235
68MP0006292_abnormal_olfactory_placode0.89087837
69MP0005379_endocrine/exocrine_gland_phen0.89037536
70MP0003656_abnormal_erythrocyte_physiolo0.88940397
71MP0005501_abnormal_skin_physiology0.84804812
72MP0000647_abnormal_sebaceous_gland0.83458527
73MP0002098_abnormal_vibrissa_morphology0.83426918
74MP0001697_abnormal_embryo_size0.82441860
75MP0001873_stomach_inflammation0.79320427
76MP0003984_embryonic_growth_retardation0.79056862
77MP0002088_abnormal_embryonic_growth/wei0.77192777
78MP0010678_abnormal_skin_adnexa0.74179826
79MP0002085_abnormal_embryonic_tissue0.74112212
80MP0000566_synostosis0.72806731
81MP0003879_abnormal_hair_cell0.71686624
82MP0010307_abnormal_tumor_latency0.71315772
83MP0000358_abnormal_cell_content/0.71018850
84MP0005647_abnormal_sex_gland0.70944975
85MP0001346_abnormal_lacrimal_gland0.69996179
86MP0001968_abnormal_touch/_nociception0.69953653
87MP0002269_muscular_atrophy0.68667344
88MP0008007_abnormal_cellular_replicative0.68006896
89MP0004782_abnormal_surfactant_physiolog0.66328715
90MP0001119_abnormal_female_reproductive0.66196626
91MP0005075_abnormal_melanosome_morpholog0.64411338
92MP0000427_abnormal_hair_cycle0.64365901
93MP0003186_abnormal_redox_activity0.62876018
94MP0002127_abnormal_cardiovascular_syste0.62632328
95MP0000627_abnormal_mammary_gland0.62365098
96MP0002229_neurodegeneration0.61091346
97MP0004145_abnormal_muscle_electrophysio0.59854438
98MP0003942_abnormal_urinary_system0.58612020
99MP0000377_abnormal_hair_follicle0.56667182
100MP0008770_decreased_survivor_rate0.56281204

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.83981866
2Hyperthyroidism (HP:0000836)4.63072427
3Truncus arteriosus (HP:0001660)4.54313190
4Tubulointerstitial nephritis (HP:0001970)4.35061153
5Male infertility (HP:0003251)4.21052402
6Hypoparathyroidism (HP:0000829)4.13738557
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.00520139
8Reticulocytosis (HP:0001923)3.87699322
9Abnormal hemoglobin (HP:0011902)3.78606721
10Azoospermia (HP:0000027)3.71725186
11Aplasia/Hypoplasia of the earlobes (HP:0009906)3.54294133
12Seborrheic dermatitis (HP:0001051)3.50623082
13Pili torti (HP:0003777)3.41353291
14Hyperkalemia (HP:0002153)3.41016119
15Bell-shaped thorax (HP:0001591)3.39118590
16Bowel incontinence (HP:0002607)3.29924017
17Abnormality of the aortic arch (HP:0012303)3.28393727
18Resting tremor (HP:0002322)3.22504984
19Abnormal large intestine physiology (HP:0012700)3.13338091
20Infertility (HP:0000789)3.05176288
21Abnormality of reticulocytes (HP:0004312)3.03225420
22Atelectasis (HP:0100750)2.95434645
23Abnormal spermatogenesis (HP:0008669)2.94901307
24Hypertensive crisis (HP:0100735)2.94508992
25Ileus (HP:0002595)2.93890284
26Absent/shortened dynein arms (HP:0200106)2.92088344
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.92088344
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85349537
29Flattened epiphyses (HP:0003071)2.83225278
30Generalized aminoaciduria (HP:0002909)2.68576359
31Curly hair (HP:0002212)2.67466278
32Bony spicule pigmentary retinopathy (HP:0007737)2.61102491
33Abnormal gallbladder physiology (HP:0012438)2.59015158
34Cholecystitis (HP:0001082)2.59015158
35Renal dysplasia (HP:0000110)2.56823978
36Congenital malformation of the right heart (HP:0011723)2.52086433
37Double outlet right ventricle (HP:0001719)2.52086433
38Septate vagina (HP:0001153)2.49692449
39Pallor (HP:0000980)2.47836888
40Tinnitus (HP:0000360)2.46656133
41Abnormality of macular pigmentation (HP:0008002)2.44266113
42Hyponatremia (HP:0002902)2.42535200
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38772291
44Enlarged epiphyses (HP:0010580)2.32131466
45Renal Fanconi syndrome (HP:0001994)2.31439681
46Abnormality of the tricuspid valve (HP:0001702)2.30519615
47Unilateral renal agenesis (HP:0000122)2.26720696
48Abnormality of lateral ventricle (HP:0030047)2.23219365
49Amelogenesis imperfecta (HP:0000705)2.19798250
50Nasal polyposis (HP:0100582)2.19426646
51Osteomalacia (HP:0002749)2.15806176
52Impulsivity (HP:0100710)2.08744941
53Decreased central vision (HP:0007663)2.08636142
54Abnormality of fatty-acid metabolism (HP:0004359)2.07319914
55Abnormality of chloride homeostasis (HP:0011422)2.01268689
56Abnormality of the parathyroid morphology (HP:0011766)2.00059677
57Attenuation of retinal blood vessels (HP:0007843)1.99501843
58Submucous cleft hard palate (HP:0000176)1.96601838
59Abnormality of the gallbladder (HP:0005264)1.95287616
60Cholelithiasis (HP:0001081)1.95232416
61Tetany (HP:0001281)1.94167159
62Concave nail (HP:0001598)1.92834215
63Cone-rod dystrophy (HP:0000548)1.92454275
64Abnormally folded helix (HP:0008544)1.91662239
65Abnormal ciliary motility (HP:0012262)1.91533390
66Hand muscle atrophy (HP:0009130)1.86702753
67Microretrognathia (HP:0000308)1.84464608
68Abnormal rod and cone electroretinograms (HP:0008323)1.84375977
69Widely patent fontanelles and sutures (HP:0004492)1.83721702
70Abnormal respiratory motile cilium physiology (HP:0012261)1.83347871
71Abnormal respiratory motile cilium morphology (HP:0005938)1.82014767
72Abnormal respiratory epithelium morphology (HP:0012253)1.82014767
73Abnormal hair laboratory examination (HP:0003328)1.81140932
74Glycosuria (HP:0003076)1.78694790
75Abnormality of urine glucose concentration (HP:0011016)1.78694790
76Poikilocytosis (HP:0004447)1.75535599
77Abnormality of sulfur amino acid metabolism (HP:0004339)1.72962063
78Postural instability (HP:0002172)1.71678267
79Abnormal number of erythroid precursors (HP:0012131)1.71512460
80Diaphragmatic weakness (HP:0009113)1.70835846
81Gout (HP:0001997)1.69055261
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68696980
83Hypoplastic ischia (HP:0003175)1.68670233
84Abnormality of the costochondral junction (HP:0000919)1.68415732
85Myopathic facies (HP:0002058)1.68358147
86Abnormal gallbladder morphology (HP:0012437)1.67895386
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.67742169
88Abnormality of the nasal mucosa (HP:0000433)1.67583863
89Abnormality of cells of the erythroid lineage (HP:0012130)1.67543143
90Sparse lateral eyebrow (HP:0005338)1.66335642
91Abnormality of the fingertips (HP:0001211)1.65125486
92Cerebral hypomyelination (HP:0006808)1.63693327
93Horizontal nystagmus (HP:0000666)1.63327378
94Patellar dislocation (HP:0002999)1.62973466
95Hyperbilirubinemia (HP:0002904)1.62492747
96Acute encephalopathy (HP:0006846)1.62409017
97Ankyloglossia (HP:0010296)1.62075332
98Severe Myopia (HP:0011003)1.61146458
99Abnormality of dental color (HP:0011073)1.60655258
100Cheekbone underdevelopment (HP:0010669)1.59965828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.87922267
2PLK45.35001190
3TESK14.22473061
4PNCK3.73799673
5BRAF2.91461501
6CDK122.64861308
7PBK2.58792415
8DDR22.35753702
9TRIB32.25966466
10TESK22.02752857
11WNK41.98522483
12PRKD31.95089382
13CDK71.79212201
14KSR21.70024212
15CAMK1G1.54829214
16RPS6KB21.53643647
17MAPK151.50400228
18PLK21.48979084
19WEE11.46418148
20EPHA21.38559539
21BRD41.36974829
22INSRR1.34088196
23EIF2AK11.32047283
24MAP3K21.30565316
25PKN21.27215895
26MET1.27050489
27VRK21.23784821
28BMX1.23268955
29NEK11.20841642
30BUB11.19836257
31PDK21.16793646
32MAP3K81.16689561
33TTK1.15402316
34NEK61.15058543
35ICK1.12228049
36WNK11.09992687
37MST1R1.07667204
38STK381.06886005
39RIPK40.99972888
40NME10.96511937
41MAPKAPK30.95670363
42AURKA0.93363578
43MAP3K90.90079742
44CHEK10.89277516
45ILK0.83159734
46MAP2K20.80365079
47PDPK10.79465300
48SRPK10.78159968
49MST40.73103051
50LATS10.72416956
51IRAK30.72015507
52MTOR0.70609774
53AURKB0.70230733
54ERN10.68879470
55CDK20.68396512
56MAP4K20.68012174
57LRRK20.67608147
58LATS20.67061429
59ARAF0.66899629
60CDK10.65448900
61TSSK60.63863594
62SMG10.63188631
63BRSK10.63017350
64NTRK30.61666799
65PRKCI0.61454493
66CDK40.60241081
67DYRK30.59984282
68NEK20.58479739
69PRKG20.56127110
70STK40.55004239
71TNK20.53309791
72PDK10.52292907
73CHEK20.49715914
74PTK2B0.49552441
75RPS6KA40.48179199
76GSK3B0.47283114
77PLK10.47184476
78RAF10.46104196
79CDC70.44483177
80PINK10.43259056
81ATR0.42652345
82SGK10.42521726
83EEF2K0.41865906
84ATM0.39351579
85CDK30.39007029
86STK160.38723028
87CSNK2A20.38262808
88STK390.37451550
89PAK10.36300769
90MARK20.36111566
91CDK11A0.35771534
92SGK4940.34697001
93SGK2230.34697001
94TRIM280.34609061
95RPS6KA10.33520378
96CSNK1E0.33280474
97RET0.32354896
98CAMK10.32318311
99DYRK1B0.32128624
100PTK60.29603797

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.70199477
2Fatty acid biosynthesis_Homo sapiens_hsa000613.70191586
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86326884
4RNA transport_Homo sapiens_hsa030132.80110806
5Ribosome_Homo sapiens_hsa030102.35341633
6Sulfur relay system_Homo sapiens_hsa041222.31804802
7Tyrosine metabolism_Homo sapiens_hsa003502.31598071
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17139379
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10581825
10Homologous recombination_Homo sapiens_hsa034402.06454959
11Basal transcription factors_Homo sapiens_hsa030222.05483539
12mRNA surveillance pathway_Homo sapiens_hsa030152.00497788
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.96379384
14Arginine and proline metabolism_Homo sapiens_hsa003301.92022561
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82443418
16DNA replication_Homo sapiens_hsa030301.78547914
17Olfactory transduction_Homo sapiens_hsa047401.76888613
18Fatty acid metabolism_Homo sapiens_hsa012121.73901542
19Mismatch repair_Homo sapiens_hsa034301.69131909
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56473366
21Spliceosome_Homo sapiens_hsa030401.53764269
22Arginine biosynthesis_Homo sapiens_hsa002201.52048586
23Thyroid cancer_Homo sapiens_hsa052161.46433060
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46200624
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.46142735
26Fanconi anemia pathway_Homo sapiens_hsa034601.45349144
27Folate biosynthesis_Homo sapiens_hsa007901.44365162
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44332347
29Huntingtons disease_Homo sapiens_hsa050161.41400012
30Butanoate metabolism_Homo sapiens_hsa006501.40252696
31Biosynthesis of amino acids_Homo sapiens_hsa012301.39886319
32RNA polymerase_Homo sapiens_hsa030201.39252766
33Oocyte meiosis_Homo sapiens_hsa041141.34691869
34Cell cycle_Homo sapiens_hsa041101.26674582
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26386589
36beta-Alanine metabolism_Homo sapiens_hsa004101.26173470
37Acute myeloid leukemia_Homo sapiens_hsa052211.24586664
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24336206
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23420325
40One carbon pool by folate_Homo sapiens_hsa006701.21660206
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17288242
42Nucleotide excision repair_Homo sapiens_hsa034201.12300292
43Taste transduction_Homo sapiens_hsa047421.10827079
44Oxidative phosphorylation_Homo sapiens_hsa001901.09561072
45Pyruvate metabolism_Homo sapiens_hsa006201.08881547
46Histidine metabolism_Homo sapiens_hsa003401.05103908
47Carbon metabolism_Homo sapiens_hsa012001.01940482
48Parkinsons disease_Homo sapiens_hsa050121.01081946
49Steroid biosynthesis_Homo sapiens_hsa001000.99724405
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98982850
51Fructose and mannose metabolism_Homo sapiens_hsa000510.95634541
52Fatty acid elongation_Homo sapiens_hsa000620.93446616
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92930628
54Purine metabolism_Homo sapiens_hsa002300.88238780
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82699047
56Cardiac muscle contraction_Homo sapiens_hsa042600.82382883
57Base excision repair_Homo sapiens_hsa034100.80350094
58Pyrimidine metabolism_Homo sapiens_hsa002400.78963667
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.78610669
60N-Glycan biosynthesis_Homo sapiens_hsa005100.75494830
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.75268032
62Regulation of autophagy_Homo sapiens_hsa041400.74468355
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73437100
64Peroxisome_Homo sapiens_hsa041460.73038882
65Fatty acid degradation_Homo sapiens_hsa000710.71248890
66Glutathione metabolism_Homo sapiens_hsa004800.70021131
67mTOR signaling pathway_Homo sapiens_hsa041500.68664266
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67820283
69VEGF signaling pathway_Homo sapiens_hsa043700.65953997
70Type II diabetes mellitus_Homo sapiens_hsa049300.64834399
71Metabolic pathways_Homo sapiens_hsa011000.62093382
72Propanoate metabolism_Homo sapiens_hsa006400.59632382
73Non-small cell lung cancer_Homo sapiens_hsa052230.58899700
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.58259520
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57995495
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54909859
77Prolactin signaling pathway_Homo sapiens_hsa049170.53789464
78Bladder cancer_Homo sapiens_hsa052190.53505580
79Insulin signaling pathway_Homo sapiens_hsa049100.52351191
80ErbB signaling pathway_Homo sapiens_hsa040120.51615292
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50713004
82Other glycan degradation_Homo sapiens_hsa005110.50564989
83Viral carcinogenesis_Homo sapiens_hsa052030.46155250
84Selenocompound metabolism_Homo sapiens_hsa004500.45278964
85RNA degradation_Homo sapiens_hsa030180.44215100
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43169738
87AMPK signaling pathway_Homo sapiens_hsa041520.40977849
88Vibrio cholerae infection_Homo sapiens_hsa051100.39534701
89Proteasome_Homo sapiens_hsa030500.37132303
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.35060555
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.34340612
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33923872
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33266784
94Prostate cancer_Homo sapiens_hsa052150.30621371
95Epstein-Barr virus infection_Homo sapiens_hsa051690.30311243
96Vitamin digestion and absorption_Homo sapiens_hsa049770.29278718
97Synaptic vesicle cycle_Homo sapiens_hsa047210.28860151
98Chronic myeloid leukemia_Homo sapiens_hsa052200.28695508
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27930470
100Endometrial cancer_Homo sapiens_hsa052130.25109191

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