ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	7.62244442
2	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	7.50270895
3	chromosome condensation (GO:0030261)	7.39467146
4	DNA packaging (GO:0006323)	7.20987592
5	acrosome reaction (GO:0007340)	7.16806510
6	sperm motility (GO:0030317)	6.67611795
7	regulation of retinoic acid receptor signaling pathway (GO:0048385)	6.34442745
8	male meiosis I (GO:0007141)	6.21940429
9	binding of sperm to zona pellucida (GO:0007339)	5.97672879
10	rRNA methylation (GO:0031167)	5.94734238
11	spermatid development (GO:0007286)	5.79464509
12	sperm capacitation (GO:0048240)	5.79236012
13	microtubule depolymerization (GO:0007019)	5.71430251
14	spermatid nucleus differentiation (GO:0007289)	5.65740272
15	plasma membrane fusion (GO:0045026)	5.63606558
16	rRNA modification (GO:0000154)	5.62571975
17	sperm-egg recognition (GO:0035036)	5.57453133
18	DNA methylation involved in gamete generation (GO:0043046)	5.16909071
19	oxygen transport (GO:0015671)	5.10699069
20	meiosis I (GO:0007127)	5.03441913
21	gas transport (GO:0015669)	4.87995913
22	male meiosis (GO:0007140)	4.87556818
23	response to pheromone (GO:0019236)	4.82293680
24	histone H3-K9 demethylation (GO:0033169)	4.81079746
25	synapsis (GO:0007129)	4.69572203
26	microtubule polymerization or depolymerization (GO:0031109)	4.54684001
27	cell-cell recognition (GO:0009988)	4.44183350
28	piRNA metabolic process (GO:0034587)	4.43820005
29	negative regulation of inclusion body assembly (GO:0090084)	4.40594909
30	chromosome organization involved in meiosis (GO:0070192)	4.30864502
31	calcium ion-dependent exocytosis (GO:0017156)	4.29070090
32	* spermatogenesis (GO:0007283)	4.25850110
33	* male gamete generation (GO:0048232)	4.25310419
34	multicellular organism reproduction (GO:0032504)	4.16595168
35	single strand break repair (GO:0000012)	4.15401225
36	synaptonemal complex assembly (GO:0007130)	4.12321103
37	sexual reproduction (GO:0019953)	4.08299436
38	meiotic nuclear division (GO:0007126)	4.07838275
39	reproduction (GO:0000003)	3.98623915
40	* gamete generation (GO:0007276)	3.96767109
41	nuclear pore complex assembly (GO:0051292)	3.91553320
42	urinary tract smooth muscle contraction (GO:0014848)	3.91536708
43	centriole replication (GO:0007099)	3.85532507
44	centriole assembly (GO:0098534)	3.80151376
45	protein-DNA complex disassembly (GO:0032986)	3.70136860
46	nucleosome disassembly (GO:0006337)	3.70136860
47	regulation of histone H3-K27 methylation (GO:0061085)	3.66067930
48	regulation of centriole replication (GO:0046599)	3.65375310
49	motile cilium assembly (GO:0044458)	3.61115243
50	synaptonemal complex organization (GO:0070193)	3.56486158
51	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.54942527
52	resolution of meiotic recombination intermediates (GO:0000712)	3.51278619
53	polyamine biosynthetic process (GO:0006596)	3.50981463
54	regulation of cilium movement (GO:0003352)	3.50349761
55	regulation of microtubule-based movement (GO:0060632)	3.50341697
56	protein polyglutamylation (GO:0018095)	3.42675693
57	microtubule severing (GO:0051013)	3.41275919
58	germ cell development (GO:0007281)	3.40033390
59	meiotic cell cycle process (GO:1903046)	3.39019948
60	nuclear pore organization (GO:0006999)	3.37101117
61	regulation of inclusion body assembly (GO:0090083)	3.36810365
62	proline biosynthetic process (GO:0006561)	3.34570648
63	nucleus organization (GO:0006997)	3.31668351
64	short-chain fatty acid metabolic process (GO:0046459)	3.25979527
65	negative regulation of gene silencing (GO:0060969)	3.24639845
66	muscle organ morphogenesis (GO:0048644)	3.22671289
67	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.21962728
68	* multicellular organismal reproductive process (GO:0048609)	3.17553217
69	phosphatidylethanolamine metabolic process (GO:0046337)	3.16116154
70	chaperone-mediated protein complex assembly (GO:0051131)	3.10370299
71	DNA conformation change (GO:0071103)	3.08666544
72	cellular ketone body metabolic process (GO:0046950)	3.05548433
73	DNA synthesis involved in DNA repair (GO:0000731)	3.04343160
74	regulation of histone H3-K4 methylation (GO:0051569)	3.03372305
75	axonemal dynein complex assembly (GO:0070286)	3.02742885
76	cell wall macromolecule catabolic process (GO:0016998)	3.01797818
77	chromatin silencing (GO:0006342)	3.00734484
78	RNA methylation (GO:0001510)	2.96244175
79	mitotic chromosome condensation (GO:0007076)	2.96119293
80	regulation of somitogenesis (GO:0014807)	2.94970153
81	regulation of RNA export from nucleus (GO:0046831)	2.93588145
82	autophagic vacuole fusion (GO:0000046)	2.92908710
83	fertilization (GO:0009566)	2.85895231
84	histone exchange (GO:0043486)	2.85249332
85	negative regulation of histone methylation (GO:0031061)	2.84237101
86	somite rostral/caudal axis specification (GO:0032525)	2.83068030
87	histone H4 deacetylation (GO:0070933)	2.80046582
88	protein targeting to Golgi (GO:0000042)	2.78207824
89	regulation of histone H3-K9 methylation (GO:0051570)	2.77341866
90	pore complex assembly (GO:0046931)	2.76446534
91	negative regulation of Notch signaling pathway (GO:0045746)	2.74019134
92	peristalsis (GO:0030432)	2.73090688
93	response to food (GO:0032094)	2.71839408
94	positive regulation of gene expression, epigenetic (GO:0045815)	2.66833295
95	face development (GO:0060324)	2.66141054
96	response to dietary excess (GO:0002021)	2.65861945
97	cell wall macromolecule metabolic process (GO:0044036)	2.65584118
98	ketone body metabolic process (GO:1902224)	2.65455342
99	regulation of histone methylation (GO:0031060)	2.63947265
100	regulation of translational fidelity (GO:0006450)	2.63670297

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.76924591
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.62464165
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.04206663
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.52487830
5	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.44384350
6	ZNF263_19887448_ChIP-Seq_K562_Human	2.15400850
7	P68_20966046_ChIP-Seq_HELA_Human	2.13132216
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.12753710
9	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.12731854
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.00326551
11	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.00204167
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97765375
13	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.93085176
14	SMC4_20622854_ChIP-Seq_HELA_Human	1.92921281
15	NCOR1_26117541_ChIP-Seq_K562_Human	1.91365040
16	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.90752759
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90183533
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.87173256
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.83585227
20	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.80593841
21	XRN2_22483619_ChIP-Seq_HELA_Human	1.74105728
22	LXR_22292898_ChIP-Seq_THP-1_Human	1.73077092
23	E2F1_20622854_ChIP-Seq_HELA_Human	1.72480263
24	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.69764983
25	BCOR_27268052_Chip-Seq_Bcells_Human	1.65736057
26	ERA_21632823_ChIP-Seq_H3396_Human	1.65478927
27	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.62855453
28	AR_21909140_ChIP-Seq_LNCAP_Human	1.62611087
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.62453917
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.61173175
31	RAC3_21632823_ChIP-Seq_H3396_Human	1.56851814
32	PHF8_20622854_ChIP-Seq_HELA_Human	1.56106552
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.56090878
34	BCL6_27268052_Chip-Seq_Bcells_Human	1.55994121
35	KDM5A_27292631_Chip-Seq_BREAST_Human	1.53391649
36	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.53282104
37	CTCF_20526341_ChIP-Seq_ESCs_Human	1.52918927
38	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.51921095
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.51143824
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.50747153
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.50690130
42	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.45775433
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45685269
44	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.42981043
45	CTCF_27219007_Chip-Seq_Bcells_Human	1.42647656
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.40150786
47	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.39666156
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.38503544
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.38411754
50	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.36784680
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.36098222
52	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.35352105
53	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.34451377
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.34296160
55	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.33934267
56	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.32219963
57	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.30568848
58	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.28723544
59	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.28540118
60	P300_27268052_Chip-Seq_Bcells_Human	1.26485353
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26027088
62	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25180890
63	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24756287
64	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.23161796
65	CTCF_21964334_Chip-Seq_Bcells_Human	1.22826030
66	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.22281576
67	GATA1_19941826_ChIP-Seq_K562_Human	1.19851417
68	TP63_22573176_ChIP-Seq_HFKS_Human	1.19442587
69	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.18470787
70	P53_21459846_ChIP-Seq_SAOS-2_Human	1.17707003
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.17288719
72	SA1_27219007_Chip-Seq_Bcells_Human	1.15845506
73	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.15636352
74	ELF5_23300383_ChIP-Seq_T47D_Human	1.15329687
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15123836
76	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14790455
77	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.14682173
78	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.13634046
79	RACK7_27058665_Chip-Seq_MCF-7_Human	1.13382843
80	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.09708064
81	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.09079059
82	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.07390529
83	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05969938
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05348525
85	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04858033
86	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.04429301
87	STAT1_20625510_ChIP-Seq_HELA_Human	1.02947909
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.01546245
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.00198786
90	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.99618402
91	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.99237261
92	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.97803443
93	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97056627
94	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.96871738
95	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.96750284
96	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.96031327
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95059652
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94846359
99	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94657187
100	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.92852646

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.96917024
2	MP0005377_hearing/vestibular/ear_phenot	3.74239001
3	MP0003878_abnormal_ear_physiology	3.74239001
4	MP0003698_abnormal_male_reproductive	3.64122238
5	MP0001929_abnormal_gametogenesis	3.54264056
6	MP0000678_abnormal_parathyroid_gland	3.39510631
7	MP0010234_abnormal_vibrissa_follicle	3.06043210
8	MP0003718_maternal_effect	2.83806601
9	MP0002210_abnormal_sex_determination	2.66764637
10	MP0003693_abnormal_embryo_hatching	2.63358772
11	MP0008995_early_reproductive_senescence	2.44786336
12	MP0004957_abnormal_blastocyst_morpholog	2.24855784
13	MP0005083_abnormal_biliary_tract	2.24282676
14	MP0002161_abnormal_fertility/fecundity	2.21395201
15	MP0000372_irregular_coat_pigmentation	2.14644424
16	MP0004233_abnormal_muscle_weight	2.09636460
17	MP0001145_abnormal_male_reproductive	2.03613992
18	MP0008877_abnormal_DNA_methylation	2.00056612
19	MP0001348_abnormal_lacrimal_gland	1.99345397
20	MP0008058_abnormal_DNA_repair	1.94186717
21	MP0005670_abnormal_white_adipose	1.94149911
22	MP0005451_abnormal_body_composition	1.93529304
23	MP0003077_abnormal_cell_cycle	1.91606679
24	MP0000653_abnormal_sex_gland	1.89052589
25	MP0002132_abnormal_respiratory_system	1.78950903
26	MP0005310_abnormal_salivary_gland	1.71795670
27	MP0002796_impaired_skin_barrier	1.71101750
28	MP0003123_paternal_imprinting	1.62324218
29	MP0004147_increased_porphyrin_level	1.60713957
30	MP0002249_abnormal_larynx_morphology	1.55267385
31	MP0003111_abnormal_nucleus_morphology	1.55153093
32	MP0003786_premature_aging	1.50452244
33	MP0001188_hyperpigmentation	1.42885243
34	MP0000681_abnormal_thyroid_gland	1.38346850
35	MP0005423_abnormal_somatic_nervous	1.35512279
36	MP0010094_abnormal_chromosome_stability	1.34296965
37	MP0009697_abnormal_copulation	1.26815294
38	MP0003646_muscle_fatigue	1.25298110
39	MP0004264_abnormal_extraembryonic_tissu	1.19466320
40	MP0005395_other_phenotype	1.17331231
41	MP0003699_abnormal_female_reproductive	1.17075068
42	MP0003936_abnormal_reproductive_system	1.14013876
43	MP0003136_yellow_coat_color	1.13121665
44	MP0006036_abnormal_mitochondrial_physio	1.11975682
45	MP0005397_hematopoietic_system_phenotyp	1.09273181
46	MP0001545_abnormal_hematopoietic_system	1.09273181
47	MP0005636_abnormal_mineral_homeostasis	1.09147830
48	MP0003011_delayed_dark_adaptation	1.06733628
49	MP0004885_abnormal_endolymph	1.06394251
50	MP0005408_hypopigmentation	1.05802756
51	MP0001672_abnormal_embryogenesis/_devel	1.05148687
52	MP0005380_embryogenesis_phenotype	1.05148687
53	MP0001666_abnormal_nutrient_absorption	1.04951097
54	MP0002234_abnormal_pharynx_morphology	1.04707864
55	MP0001881_abnormal_mammary_gland	1.02353332
56	MP0008932_abnormal_embryonic_tissue	1.00677299
57	MP0005058_abnormal_lysosome_morphology	0.99831667
58	MP0004019_abnormal_vitamin_homeostasis	0.98133247
59	MP0008057_abnormal_DNA_replication	0.97600419
60	MP0002160_abnormal_reproductive_system	0.96189189
61	MP0004381_abnormal_hair_follicle	0.94431182
62	MP0000350_abnormal_cell_proliferation	0.94141269
63	MP0006035_abnormal_mitochondrial_morpho	0.93748053
64	MP0000313_abnormal_cell_death	0.93293986
65	MP0001765_abnormal_ion_homeostasis	0.91239939
66	MP0002080_prenatal_lethality	0.90846054
67	MP0001730_embryonic_growth_arrest	0.89364235
68	MP0006292_abnormal_olfactory_placode	0.89087837
69	MP0005379_endocrine/exocrine_gland_phen	0.89037536
70	MP0003656_abnormal_erythrocyte_physiolo	0.88940397
71	MP0005501_abnormal_skin_physiology	0.84804812
72	MP0000647_abnormal_sebaceous_gland	0.83458527
73	MP0002098_abnormal_vibrissa_morphology	0.83426918
74	MP0001697_abnormal_embryo_size	0.82441860
75	MP0001873_stomach_inflammation	0.79320427
76	MP0003984_embryonic_growth_retardation	0.79056862
77	MP0002088_abnormal_embryonic_growth/wei	0.77192777
78	MP0010678_abnormal_skin_adnexa	0.74179826
79	MP0002085_abnormal_embryonic_tissue	0.74112212
80	MP0000566_synostosis	0.72806731
81	MP0003879_abnormal_hair_cell	0.71686624
82	MP0010307_abnormal_tumor_latency	0.71315772
83	MP0000358_abnormal_cell_content/	0.71018850
84	MP0005647_abnormal_sex_gland	0.70944975
85	MP0001346_abnormal_lacrimal_gland	0.69996179
86	MP0001968_abnormal_touch/_nociception	0.69953653
87	MP0002269_muscular_atrophy	0.68667344
88	MP0008007_abnormal_cellular_replicative	0.68006896
89	MP0004782_abnormal_surfactant_physiolog	0.66328715
90	MP0001119_abnormal_female_reproductive	0.66196626
91	MP0005075_abnormal_melanosome_morpholog	0.64411338
92	MP0000427_abnormal_hair_cycle	0.64365901
93	MP0003186_abnormal_redox_activity	0.62876018
94	MP0002127_abnormal_cardiovascular_syste	0.62632328
95	MP0000627_abnormal_mammary_gland	0.62365098
96	MP0002229_neurodegeneration	0.61091346
97	MP0004145_abnormal_muscle_electrophysio	0.59854438
98	MP0003942_abnormal_urinary_system	0.58612020
99	MP0000377_abnormal_hair_follicle	0.56667182
100	MP0008770_decreased_survivor_rate	0.56281204

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	4.83981866
2	Hyperthyroidism (HP:0000836)	4.63072427
3	Truncus arteriosus (HP:0001660)	4.54313190
4	Tubulointerstitial nephritis (HP:0001970)	4.35061153
5	Male infertility (HP:0003251)	4.21052402
6	Hypoparathyroidism (HP:0000829)	4.13738557
7	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.00520139
8	Reticulocytosis (HP:0001923)	3.87699322
9	Abnormal hemoglobin (HP:0011902)	3.78606721
10	Azoospermia (HP:0000027)	3.71725186
11	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.54294133
12	Seborrheic dermatitis (HP:0001051)	3.50623082
13	Pili torti (HP:0003777)	3.41353291
14	Hyperkalemia (HP:0002153)	3.41016119
15	Bell-shaped thorax (HP:0001591)	3.39118590
16	Bowel incontinence (HP:0002607)	3.29924017
17	Abnormality of the aortic arch (HP:0012303)	3.28393727
18	Resting tremor (HP:0002322)	3.22504984
19	Abnormal large intestine physiology (HP:0012700)	3.13338091
20	Infertility (HP:0000789)	3.05176288
21	Abnormality of reticulocytes (HP:0004312)	3.03225420
22	Atelectasis (HP:0100750)	2.95434645
23	Abnormal spermatogenesis (HP:0008669)	2.94901307
24	Hypertensive crisis (HP:0100735)	2.94508992
25	Ileus (HP:0002595)	2.93890284
26	Absent/shortened dynein arms (HP:0200106)	2.92088344
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.92088344
28	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.85349537
29	Flattened epiphyses (HP:0003071)	2.83225278
30	Generalized aminoaciduria (HP:0002909)	2.68576359
31	Curly hair (HP:0002212)	2.67466278
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.61102491
33	Abnormal gallbladder physiology (HP:0012438)	2.59015158
34	Cholecystitis (HP:0001082)	2.59015158
35	Renal dysplasia (HP:0000110)	2.56823978
36	Congenital malformation of the right heart (HP:0011723)	2.52086433
37	Double outlet right ventricle (HP:0001719)	2.52086433
38	Septate vagina (HP:0001153)	2.49692449
39	Pallor (HP:0000980)	2.47836888
40	Tinnitus (HP:0000360)	2.46656133
41	Abnormality of macular pigmentation (HP:0008002)	2.44266113
42	Hyponatremia (HP:0002902)	2.42535200
43	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.38772291
44	Enlarged epiphyses (HP:0010580)	2.32131466
45	Renal Fanconi syndrome (HP:0001994)	2.31439681
46	Abnormality of the tricuspid valve (HP:0001702)	2.30519615
47	Unilateral renal agenesis (HP:0000122)	2.26720696
48	Abnormality of lateral ventricle (HP:0030047)	2.23219365
49	Amelogenesis imperfecta (HP:0000705)	2.19798250
50	Nasal polyposis (HP:0100582)	2.19426646
51	Osteomalacia (HP:0002749)	2.15806176
52	Impulsivity (HP:0100710)	2.08744941
53	Decreased central vision (HP:0007663)	2.08636142
54	Abnormality of fatty-acid metabolism (HP:0004359)	2.07319914
55	Abnormality of chloride homeostasis (HP:0011422)	2.01268689
56	Abnormality of the parathyroid morphology (HP:0011766)	2.00059677
57	Attenuation of retinal blood vessels (HP:0007843)	1.99501843
58	Submucous cleft hard palate (HP:0000176)	1.96601838
59	Abnormality of the gallbladder (HP:0005264)	1.95287616
60	Cholelithiasis (HP:0001081)	1.95232416
61	Tetany (HP:0001281)	1.94167159
62	Concave nail (HP:0001598)	1.92834215
63	Cone-rod dystrophy (HP:0000548)	1.92454275
64	Abnormally folded helix (HP:0008544)	1.91662239
65	Abnormal ciliary motility (HP:0012262)	1.91533390
66	Hand muscle atrophy (HP:0009130)	1.86702753
67	Microretrognathia (HP:0000308)	1.84464608
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.84375977
69	Widely patent fontanelles and sutures (HP:0004492)	1.83721702
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83347871
71	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82014767
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.82014767
73	Abnormal hair laboratory examination (HP:0003328)	1.81140932
74	Glycosuria (HP:0003076)	1.78694790
75	Abnormality of urine glucose concentration (HP:0011016)	1.78694790
76	Poikilocytosis (HP:0004447)	1.75535599
77	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.72962063
78	Postural instability (HP:0002172)	1.71678267
79	Abnormal number of erythroid precursors (HP:0012131)	1.71512460
80	Diaphragmatic weakness (HP:0009113)	1.70835846
81	Gout (HP:0001997)	1.69055261
82	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.68696980
83	Hypoplastic ischia (HP:0003175)	1.68670233
84	Abnormality of the costochondral junction (HP:0000919)	1.68415732
85	Myopathic facies (HP:0002058)	1.68358147
86	Abnormal gallbladder morphology (HP:0012437)	1.67895386
87	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.67742169
88	Abnormality of the nasal mucosa (HP:0000433)	1.67583863
89	Abnormality of cells of the erythroid lineage (HP:0012130)	1.67543143
90	Sparse lateral eyebrow (HP:0005338)	1.66335642
91	Abnormality of the fingertips (HP:0001211)	1.65125486
92	Cerebral hypomyelination (HP:0006808)	1.63693327
93	Horizontal nystagmus (HP:0000666)	1.63327378
94	Patellar dislocation (HP:0002999)	1.62973466
95	Hyperbilirubinemia (HP:0002904)	1.62492747
96	Acute encephalopathy (HP:0006846)	1.62409017
97	Ankyloglossia (HP:0010296)	1.62075332
98	Severe Myopia (HP:0011003)	1.61146458
99	Abnormality of dental color (HP:0011073)	1.60655258
100	Cheekbone underdevelopment (HP:0010669)	1.59965828

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	5.87922267
2	PLK4	5.35001190
3	TESK1	4.22473061
4	PNCK	3.73799673
5	BRAF	2.91461501
6	CDK12	2.64861308
7	PBK	2.58792415
8	DDR2	2.35753702
9	TRIB3	2.25966466
10	TESK2	2.02752857
11	WNK4	1.98522483
12	PRKD3	1.95089382
13	CDK7	1.79212201
14	KSR2	1.70024212
15	CAMK1G	1.54829214
16	RPS6KB2	1.53643647
17	MAPK15	1.50400228
18	PLK2	1.48979084
19	WEE1	1.46418148
20	EPHA2	1.38559539
21	BRD4	1.36974829
22	INSRR	1.34088196
23	EIF2AK1	1.32047283
24	MAP3K2	1.30565316
25	PKN2	1.27215895
26	MET	1.27050489
27	VRK2	1.23784821
28	BMX	1.23268955
29	NEK1	1.20841642
30	BUB1	1.19836257
31	PDK2	1.16793646
32	MAP3K8	1.16689561
33	TTK	1.15402316
34	NEK6	1.15058543
35	ICK	1.12228049
36	WNK1	1.09992687
37	MST1R	1.07667204
38	STK38	1.06886005
39	RIPK4	0.99972888
40	NME1	0.96511937
41	MAPKAPK3	0.95670363
42	AURKA	0.93363578
43	MAP3K9	0.90079742
44	CHEK1	0.89277516
45	ILK	0.83159734
46	MAP2K2	0.80365079
47	PDPK1	0.79465300
48	SRPK1	0.78159968
49	MST4	0.73103051
50	LATS1	0.72416956
51	IRAK3	0.72015507
52	MTOR	0.70609774
53	AURKB	0.70230733
54	ERN1	0.68879470
55	CDK2	0.68396512
56	MAP4K2	0.68012174
57	LRRK2	0.67608147
58	LATS2	0.67061429
59	ARAF	0.66899629
60	CDK1	0.65448900
61	TSSK6	0.63863594
62	SMG1	0.63188631
63	BRSK1	0.63017350
64	NTRK3	0.61666799
65	PRKCI	0.61454493
66	CDK4	0.60241081
67	DYRK3	0.59984282
68	NEK2	0.58479739
69	PRKG2	0.56127110
70	STK4	0.55004239
71	TNK2	0.53309791
72	PDK1	0.52292907
73	CHEK2	0.49715914
74	PTK2B	0.49552441
75	RPS6KA4	0.48179199
76	GSK3B	0.47283114
77	PLK1	0.47184476
78	RAF1	0.46104196
79	CDC7	0.44483177
80	PINK1	0.43259056
81	ATR	0.42652345
82	SGK1	0.42521726
83	EEF2K	0.41865906
84	ATM	0.39351579
85	CDK3	0.39007029
86	STK16	0.38723028
87	CSNK2A2	0.38262808
88	STK39	0.37451550
89	PAK1	0.36300769
90	MARK2	0.36111566
91	CDK11A	0.35771534
92	SGK223	0.34697001
93	SGK494	0.34697001
94	TRIM28	0.34609061
95	RPS6KA1	0.33520378
96	CSNK1E	0.33280474
97	RET	0.32354896
98	CAMK1	0.32318311
99	DYRK1B	0.32128624
100	PTK6	0.29603797

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine metabolism_Homo sapiens_hsa00360	3.70199477
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.70191586
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.86326884
4	RNA transport_Homo sapiens_hsa03013	2.80110806
5	Ribosome_Homo sapiens_hsa03010	2.35341633
6	Sulfur relay system_Homo sapiens_hsa04122	2.31804802
7	Tyrosine metabolism_Homo sapiens_hsa00350	2.31598071
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.17139379
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10581825
10	Homologous recombination_Homo sapiens_hsa03440	2.06454959
11	Basal transcription factors_Homo sapiens_hsa03022	2.05483539
12	mRNA surveillance pathway_Homo sapiens_hsa03015	2.00497788
13	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.96379384
14	Arginine and proline metabolism_Homo sapiens_hsa00330	1.92022561
15	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.82443418
16	DNA replication_Homo sapiens_hsa03030	1.78547914
17	Olfactory transduction_Homo sapiens_hsa04740	1.76888613
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.73901542
19	Mismatch repair_Homo sapiens_hsa03430	1.69131909
20	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.56473366
21	Spliceosome_Homo sapiens_hsa03040	1.53764269
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.52048586
23	Thyroid cancer_Homo sapiens_hsa05216	1.46433060
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.46200624
25	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.46142735
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45349144
27	Folate biosynthesis_Homo sapiens_hsa00790	1.44365162
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.44332347
29	Huntingtons disease_Homo sapiens_hsa05016	1.41400012
30	Butanoate metabolism_Homo sapiens_hsa00650	1.40252696
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.39886319
32	RNA polymerase_Homo sapiens_hsa03020	1.39252766
33	Oocyte meiosis_Homo sapiens_hsa04114	1.34691869
34	Cell cycle_Homo sapiens_hsa04110	1.26674582
35	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.26386589
36	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26173470
37	Acute myeloid leukemia_Homo sapiens_hsa05221	1.24586664
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.24336206
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23420325
40	One carbon pool by folate_Homo sapiens_hsa00670	1.21660206
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.17288242
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.12300292
43	Taste transduction_Homo sapiens_hsa04742	1.10827079
44	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09561072
45	Pyruvate metabolism_Homo sapiens_hsa00620	1.08881547
46	Histidine metabolism_Homo sapiens_hsa00340	1.05103908
47	Carbon metabolism_Homo sapiens_hsa01200	1.01940482
48	Parkinsons disease_Homo sapiens_hsa05012	1.01081946
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.99724405
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.98982850
51	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.95634541
52	Fatty acid elongation_Homo sapiens_hsa00062	0.93446616
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.92930628
54	Purine metabolism_Homo sapiens_hsa00230	0.88238780
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82699047
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.82382883
57	Base excision repair_Homo sapiens_hsa03410	0.80350094
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78963667
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78610669
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75494830
61	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.75268032
62	Regulation of autophagy_Homo sapiens_hsa04140	0.74468355
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73437100
64	Peroxisome_Homo sapiens_hsa04146	0.73038882
65	Fatty acid degradation_Homo sapiens_hsa00071	0.71248890
66	Glutathione metabolism_Homo sapiens_hsa00480	0.70021131
67	mTOR signaling pathway_Homo sapiens_hsa04150	0.68664266
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.67820283
69	VEGF signaling pathway_Homo sapiens_hsa04370	0.65953997
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.64834399
71	Metabolic pathways_Homo sapiens_hsa01100	0.62093382
72	Propanoate metabolism_Homo sapiens_hsa00640	0.59632382
73	Non-small cell lung cancer_Homo sapiens_hsa05223	0.58899700
74	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.58259520
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57995495
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54909859
77	Prolactin signaling pathway_Homo sapiens_hsa04917	0.53789464
78	Bladder cancer_Homo sapiens_hsa05219	0.53505580
79	Insulin signaling pathway_Homo sapiens_hsa04910	0.52351191
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.51615292
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50713004
82	Other glycan degradation_Homo sapiens_hsa00511	0.50564989
83	Viral carcinogenesis_Homo sapiens_hsa05203	0.46155250
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.45278964
85	RNA degradation_Homo sapiens_hsa03018	0.44215100
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.43169738
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.40977849
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39534701
89	Proteasome_Homo sapiens_hsa03050	0.37132303
90	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.35060555
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34340612
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.33923872
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.33266784
94	Prostate cancer_Homo sapiens_hsa05215	0.30621371
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30311243
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29278718
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28860151
98	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.28695508
99	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.27930470
100	Endometrial cancer_Homo sapiens_hsa05213	0.25109191

VCX

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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