ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	8.47677044
2	DNA packaging (GO:0006323)	8.15383206
3	chromosome condensation (GO:0030261)	8.15026608
4	fusion of sperm to egg plasma membrane (GO:0007342)	8.07351661
5	sperm motility (GO:0030317)	7.97512347
6	male meiosis I (GO:0007141)	7.32606353
7	ribosome assembly (GO:0042255)	7.10786420
8	synapsis (GO:0007129)	6.97532661
9	rRNA methylation (GO:0031167)	6.90617157
10	microtubule depolymerization (GO:0007019)	6.90336173
11	spermatid development (GO:0007286)	6.84109676
12	binding of sperm to zona pellucida (GO:0007339)	6.61785694
13	rRNA modification (GO:0000154)	6.43714008
14	sperm-egg recognition (GO:0035036)	6.34310682
15	sperm capacitation (GO:0048240)	6.32539862
16	spermatid nucleus differentiation (GO:0007289)	6.25522122
17	chromosome organization involved in meiosis (GO:0070192)	6.08510145
18	piRNA metabolic process (GO:0034587)	6.06901046
19	negative regulation of inclusion body assembly (GO:0090084)	6.04448820
20	DNA methylation involved in gamete generation (GO:0043046)	6.02717184
21	plasma membrane fusion (GO:0045026)	6.01838331
22	male meiosis (GO:0007140)	5.99225557
23	meiosis I (GO:0007127)	5.93427574
24	synaptonemal complex assembly (GO:0007130)	5.65104891
25	response to pheromone (GO:0019236)	5.62481030
26	microtubule polymerization or depolymerization (GO:0031109)	5.23156867
27	spermatogenesis (GO:0007283)	5.14746164
28	male gamete generation (GO:0048232)	5.13824962
29	single strand break repair (GO:0000012)	5.09721431
30	cell-cell recognition (GO:0009988)	5.08533901
31	histone H3-K9 demethylation (GO:0033169)	5.07293192
32	meiotic nuclear division (GO:0007126)	4.98922006
33	synaptonemal complex organization (GO:0070193)	4.98253787
34	sexual reproduction (GO:0019953)	4.82382721
35	gamete generation (GO:0007276)	4.79781654
36	multicellular organism reproduction (GO:0032504)	4.63861240
37	calcium ion-dependent exocytosis (GO:0017156)	4.62226115
38	DNA synthesis involved in DNA repair (GO:0000731)	4.56997963
39	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.51889919
40	reproduction (GO:0000003)	4.51577421
41	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.38739795
42	regulation of inclusion body assembly (GO:0090083)	4.28140943
43	protein polyglutamylation (GO:0018095)	4.19161014
44	meiotic cell cycle process (GO:1903046)	4.18449041
45	regulation of cilium movement (GO:0003352)	4.17597732
46	microtubule severing (GO:0051013)	4.09072287
47	centriole assembly (GO:0098534)	4.08947245
48	germ cell development (GO:0007281)	4.07979306
49	nuclear pore complex assembly (GO:0051292)	4.06895147
50	resolution of meiotic recombination intermediates (GO:0000712)	4.05796920
51	motile cilium assembly (GO:0044458)	4.03005121
52	phosphatidylethanolamine metabolic process (GO:0046337)	3.98964809
53	centriole replication (GO:0007099)	3.98025880
54	cellular ketone body metabolic process (GO:0046950)	3.89135026
55	regulation of microtubule-based movement (GO:0060632)	3.88146832
56	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.85393774
57	multicellular organismal reproductive process (GO:0048609)	3.84254127
58	chaperone-mediated protein complex assembly (GO:0051131)	3.75398068
59	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.73660379
60	nucleus organization (GO:0006997)	3.66577529
61	axonemal dynein complex assembly (GO:0070286)	3.62305076
62	histone exchange (GO:0043486)	3.58448258
63	regulation of centriole replication (GO:0046599)	3.58209157
64	fertilization (GO:0009566)	3.52161579
65	protein-DNA complex disassembly (GO:0032986)	3.43704139
66	nucleosome disassembly (GO:0006337)	3.43704139
67	negative regulation of gene silencing (GO:0060969)	3.39630517
68	ketone body metabolic process (GO:1902224)	3.39388476
69	nuclear pore organization (GO:0006999)	3.37831872
70	protein targeting to Golgi (GO:0000042)	3.37479167
71	DNA conformation change (GO:0071103)	3.35468050
72	regulation of histone H3-K27 methylation (GO:0061085)	3.30601622
73	RNA methylation (GO:0001510)	3.20998111
74	gas transport (GO:0015669)	3.20467748
75	chromatin silencing (GO:0006342)	3.18008999
76	single fertilization (GO:0007338)	3.17493729
77	establishment of protein localization to Golgi (GO:0072600)	3.14427630
78	meiotic chromosome segregation (GO:0045132)	3.09328065
79	polyamine biosynthetic process (GO:0006596)	3.05636777
80	cell wall macromolecule catabolic process (GO:0016998)	3.05328968
81	regulation of meiosis I (GO:0060631)	3.04762736
82	tRNA methylation (GO:0030488)	3.04239029
83	oxygen transport (GO:0015671)	3.01648164
84	regulation of histone H3-K9 methylation (GO:0051570)	2.99240938
85	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.94151147
86	pore complex assembly (GO:0046931)	2.91645638
87	negative regulation of histone methylation (GO:0031061)	2.89830587
88	chromosome organization (GO:0051276)	2.84202235
89	protein refolding (GO:0042026)	2.81784370
90	histone H4 deacetylation (GO:0070933)	2.80245195
91	organic cation transport (GO:0015695)	2.78635123
92	muscle organ morphogenesis (GO:0048644)	2.76486763
93	mitotic chromosome condensation (GO:0007076)	2.75938494
94	gene silencing (GO:0016458)	2.75204137
95	sister chromatid cohesion (GO:0007062)	2.74361307
96	coenzyme catabolic process (GO:0009109)	2.72287308
97	cilium or flagellum-dependent cell motility (GO:0001539)	2.72237543
98	peptidyl-threonine dephosphorylation (GO:0035970)	2.71597373
99	proteasome assembly (GO:0043248)	2.70563597
100	somite rostral/caudal axis specification (GO:0032525)	2.69393670

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.38065549
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.75744615
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.29444979
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.91906020
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.70767388
6	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.55284492
7	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.42800170
8	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.41851716
9	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.11814277
10	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.06298307
11	P68_20966046_ChIP-Seq_HELA_Human	2.03982451
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.03847041
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.92728391
14	ERA_21632823_ChIP-Seq_H3396_Human	1.88425940
15	E2F1_20622854_ChIP-Seq_HELA_Human	1.87759435
16	SMC4_20622854_ChIP-Seq_HELA_Human	1.87528784
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.87478248
18	RAC3_21632823_ChIP-Seq_H3396_Human	1.81860339
19	BCOR_27268052_Chip-Seq_Bcells_Human	1.79409773
20	PHF8_20622854_ChIP-Seq_HELA_Human	1.77337755
21	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.73036807
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.72090295
23	NCOR1_26117541_ChIP-Seq_K562_Human	1.69092958
24	BCL6_27268052_Chip-Seq_Bcells_Human	1.66061135
25	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.63678485
26	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.63231539
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.62704439
28	CTCF_20526341_ChIP-Seq_ESCs_Human	1.62214371
29	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.60949527
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.52459361
31	CTCF_27219007_Chip-Seq_Bcells_Human	1.50239989
32	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.44684534
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.43186276
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.41754466
35	P300_27268052_Chip-Seq_Bcells_Human	1.40842991
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.37744249
37	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.36918796
38	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.36533026
39	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.35484770
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.35444621
41	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.34136016
42	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.32102165
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.31144728
44	P53_21459846_ChIP-Seq_SAOS-2_Human	1.30315366
45	TP63_22573176_ChIP-Seq_HFKS_Human	1.27665618
46	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.27427138
47	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.27057420
48	CTCF_21964334_Chip-Seq_Bcells_Human	1.25045363
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.24473366
50	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.24354800
51	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.24252934
52	SA1_27219007_Chip-Seq_Bcells_Human	1.24170457
53	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.23494363
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.23248277
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.23030100
56	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.22794208
57	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.22113966
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.21623623
59	ZNF263_19887448_ChIP-Seq_K562_Human	1.21547138
60	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20358120
61	RBPJ_21746931_ChIP-Seq_IB4_Human	1.19682692
62	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.19490900
63	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.19339972
64	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.19018409
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18484168
66	GABP_19822575_ChIP-Seq_HepG2_Human	1.17841898
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.17749922
68	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.17048304
69	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.16256109
70	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.16158241
71	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.16020887
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14892581
73	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.14739856
74	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.14100271
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13601788
76	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.13461954
77	GATA1_19941826_ChIP-Seq_K562_Human	1.12564943
78	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.12467698
79	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.12320300
80	OCT4_20526341_ChIP-Seq_ESCs_Human	1.11801265
81	PHF8_20622853_ChIP-Seq_HELA_Human	1.07875597
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07306174
83	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.07202579
84	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05118210
85	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04624687
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04232258
87	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.04187396
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03573812
89	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.03480965
90	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02812727
91	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02253068
92	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.01509102
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99285687
94	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.98164916
95	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97568729
96	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97543857
97	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97380720
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.96676998
99	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.96649119
100	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.95481733

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.35465118
2	MP0003698_abnormal_male_reproductive	4.43858167
3	MP0001929_abnormal_gametogenesis	4.37516163
4	MP0000678_abnormal_parathyroid_gland	3.71978115
5	MP0005377_hearing/vestibular/ear_phenot	3.58931895
6	MP0003878_abnormal_ear_physiology	3.58931895
7	MP0002210_abnormal_sex_determination	3.26873615
8	MP0005670_abnormal_white_adipose	3.12084353
9	MP0003718_maternal_effect	3.11172540
10	MP0008877_abnormal_DNA_methylation	3.05908624
11	MP0002161_abnormal_fertility/fecundity	2.67856937
12	MP0001145_abnormal_male_reproductive	2.52354717
13	MP0008058_abnormal_DNA_repair	2.40633368
14	MP0008995_early_reproductive_senescence	2.40496557
15	MP0000653_abnormal_sex_gland	2.34036484
16	MP0003693_abnormal_embryo_hatching	2.22566951
17	MP0002132_abnormal_respiratory_system	2.12215368
18	MP0005083_abnormal_biliary_tract	2.07488649
19	MP0004957_abnormal_blastocyst_morpholog	2.02391819
20	MP0003077_abnormal_cell_cycle	1.87650601
21	MP0002249_abnormal_larynx_morphology	1.75093002
22	MP0001348_abnormal_lacrimal_gland	1.70074623
23	MP0003646_muscle_fatigue	1.65052986
24	MP0010234_abnormal_vibrissa_follicle	1.59143021
25	MP0005451_abnormal_body_composition	1.58395932
26	MP0004233_abnormal_muscle_weight	1.53396312
27	MP0003111_abnormal_nucleus_morphology	1.44419147
28	MP0005310_abnormal_salivary_gland	1.39878658
29	MP0003786_premature_aging	1.39129872
30	MP0003699_abnormal_female_reproductive	1.33518132
31	MP0009697_abnormal_copulation	1.32629221
32	MP0005423_abnormal_somatic_nervous	1.32106282
33	MP0005395_other_phenotype	1.25536031
34	MP0010094_abnormal_chromosome_stability	1.23326745
35	MP0006036_abnormal_mitochondrial_physio	1.19653876
36	MP0003011_delayed_dark_adaptation	1.18536963
37	MP0002234_abnormal_pharynx_morphology	1.15513596
38	MP0000681_abnormal_thyroid_gland	1.14980233
39	MP0004019_abnormal_vitamin_homeostasis	1.13621099
40	MP0000372_irregular_coat_pigmentation	1.13216641
41	MP0002160_abnormal_reproductive_system	1.12240308
42	MP0002796_impaired_skin_barrier	1.09070578
43	MP0006035_abnormal_mitochondrial_morpho	1.03270507
44	MP0008932_abnormal_embryonic_tissue	1.02946386
45	MP0001666_abnormal_nutrient_absorption	1.02929398
46	MP0005636_abnormal_mineral_homeostasis	1.01024587
47	MP0003936_abnormal_reproductive_system	0.96749899
48	MP0004264_abnormal_extraembryonic_tissu	0.95859652
49	MP0005408_hypopigmentation	0.93220936
50	MP0000313_abnormal_cell_death	0.91604570
51	MP0004147_increased_porphyrin_level	0.91173367
52	MP0001672_abnormal_embryogenesis/_devel	0.90539970
53	MP0005380_embryogenesis_phenotype	0.90539970
54	MP0001730_embryonic_growth_arrest	0.90414176
55	MP0001119_abnormal_female_reproductive	0.89580465
56	MP0001765_abnormal_ion_homeostasis	0.86086164
57	MP0002080_prenatal_lethality	0.85890833
58	MP0008007_abnormal_cellular_replicative	0.82522732
59	MP0001188_hyperpigmentation	0.81483179
60	MP0000350_abnormal_cell_proliferation	0.80416166
61	MP0001697_abnormal_embryo_size	0.79267151
62	MP0000358_abnormal_cell_content/	0.77737256
63	MP0001764_abnormal_homeostasis	0.76179606
64	MP0002085_abnormal_embryonic_tissue	0.74813305
65	MP0006292_abnormal_olfactory_placode	0.73640855
66	MP0008789_abnormal_olfactory_epithelium	0.73360613
67	MP0005666_abnormal_adipose_tissue	0.72893655
68	MP0002282_abnormal_trachea_morphology	0.71425230
69	MP0010307_abnormal_tumor_latency	0.68098467
70	MP0002269_muscular_atrophy	0.67766675
71	MP0002127_abnormal_cardiovascular_syste	0.64936155
72	MP0001881_abnormal_mammary_gland	0.64716811
73	MP0005365_abnormal_bile_salt	0.64445339
74	MP0003806_abnormal_nucleotide_metabolis	0.63418566
75	MP0005647_abnormal_sex_gland	0.62795259
76	MP0005389_reproductive_system_phenotype	0.61240085
77	MP0002084_abnormal_developmental_patter	0.61226845
78	MP0003984_embryonic_growth_retardation	0.59711309
79	MP0003879_abnormal_hair_cell	0.59334753
80	MP0005397_hematopoietic_system_phenotyp	0.58813450
81	MP0001545_abnormal_hematopoietic_system	0.58813450
82	MP0008057_abnormal_DNA_replication	0.57364395
83	MP0003186_abnormal_redox_activity	0.56917538
84	MP0002088_abnormal_embryonic_growth/wei	0.56546066
85	MP0002229_neurodegeneration	0.56330394
86	MP0000534_abnormal_ureter_morphology	0.56047543
87	MP0005499_abnormal_olfactory_system	0.51270320
88	MP0005394_taste/olfaction_phenotype	0.51270320
89	MP0004782_abnormal_surfactant_physiolog	0.51023160
90	MP0001661_extended_life_span	0.50933377
91	MP0002653_abnormal_ependyma_morphology	0.50098640
92	MP0000647_abnormal_sebaceous_gland	0.48881891
93	MP0002086_abnormal_extraembryonic_tissu	0.47938890
94	MP0004085_abnormal_heartbeat	0.47273952
95	MP0001968_abnormal_touch/_nociception	0.47258379
96	MP0003942_abnormal_urinary_system	0.45976105
97	MP0008770_decreased_survivor_rate	0.45861515
98	MP0005332_abnormal_amino_acid	0.45837263
99	MP0005058_abnormal_lysosome_morphology	0.45008402
100	MP0002139_abnormal_hepatobiliary_system	0.44444725

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.17939839
2	Tubulointerstitial nephritis (HP:0001970)	5.14697362
3	Azoospermia (HP:0000027)	4.92566646
4	Male infertility (HP:0003251)	4.32287569
5	Abnormal spermatogenesis (HP:0008669)	4.11477329
6	Hyperthyroidism (HP:0000836)	4.02333747
7	Truncus arteriosus (HP:0001660)	3.89492836
8	Hyperkalemia (HP:0002153)	3.81779869
9	Resting tremor (HP:0002322)	3.77946254
10	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.74053192
11	Hypoparathyroidism (HP:0000829)	3.63541741
12	Bell-shaped thorax (HP:0001591)	3.59799758
13	Absent/shortened dynein arms (HP:0200106)	3.51210072
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.51210072
15	Infertility (HP:0000789)	3.46683674
16	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.39258084
17	Bony spicule pigmentary retinopathy (HP:0007737)	3.30524778
18	Seborrheic dermatitis (HP:0001051)	3.08174610
19	Reticulocytosis (HP:0001923)	3.05062857
20	Bowel incontinence (HP:0002607)	3.04629876
21	Abnormality of the aortic arch (HP:0012303)	3.04258065
22	Flattened epiphyses (HP:0003071)	2.94319352
23	Attenuation of retinal blood vessels (HP:0007843)	2.93797680
24	Atelectasis (HP:0100750)	2.87214442
25	Abnormal large intestine physiology (HP:0012700)	2.86862156
26	Abnormality of macular pigmentation (HP:0008002)	2.84236480
27	Generalized aminoaciduria (HP:0002909)	2.79841754
28	Nasal polyposis (HP:0100582)	2.60977868
29	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.58445715
30	Unilateral renal agenesis (HP:0000122)	2.57710412
31	Hypertensive crisis (HP:0100735)	2.55977228
32	Abnormal respiratory motile cilium physiology (HP:0012261)	2.51060903
33	Abnormal gallbladder physiology (HP:0012438)	2.48909694
34	Cholecystitis (HP:0001082)	2.48909694
35	Congenital malformation of the right heart (HP:0011723)	2.47604653
36	Double outlet right ventricle (HP:0001719)	2.47604653
37	Abnormal ciliary motility (HP:0012262)	2.41707597
38	Osteomalacia (HP:0002749)	2.41600582
39	Pili torti (HP:0003777)	2.38858744
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.36224155
41	Amelogenesis imperfecta (HP:0000705)	2.35606188
42	Hand muscle atrophy (HP:0009130)	2.35161305
43	Tetany (HP:0001281)	2.33825526
44	Enlarged epiphyses (HP:0010580)	2.32758772
45	Upper limb muscle weakness (HP:0003484)	2.31442566
46	Hyponatremia (HP:0002902)	2.30158458
47	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.29061048
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.28543605
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.28543605
50	Renal Fanconi syndrome (HP:0001994)	2.27924749
51	Renal dysplasia (HP:0000110)	2.27829491
52	Abnormality of reticulocytes (HP:0004312)	2.27111176
53	Abnormality of the parathyroid morphology (HP:0011766)	2.21209695
54	Cone-rod dystrophy (HP:0000548)	2.20143584
55	Ileus (HP:0002595)	2.10679818
56	Tinnitus (HP:0000360)	2.09790393
57	Facial shape deformation (HP:0011334)	2.09752411
58	Potter facies (HP:0002009)	2.09752411
59	Abnormality of lateral ventricle (HP:0030047)	2.08383707
60	Abnormality of the tricuspid valve (HP:0001702)	2.07848398
61	Abnormality of chloride homeostasis (HP:0011422)	2.05156649
62	Horizontal nystagmus (HP:0000666)	2.03321831
63	Abnormal hemoglobin (HP:0011902)	2.03025685
64	Impulsivity (HP:0100710)	2.00331510
65	Spontaneous abortion (HP:0005268)	1.98070069
66	Abnormality of the nasal mucosa (HP:0000433)	1.97622540
67	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.93484187
68	Duodenal stenosis (HP:0100867)	1.91967934
69	Small intestinal stenosis (HP:0012848)	1.91967934
70	Chronic hepatic failure (HP:0100626)	1.90696830
71	Cholelithiasis (HP:0001081)	1.90678798
72	Hypoplastic left heart (HP:0004383)	1.88358835
73	Postural instability (HP:0002172)	1.84886693
74	Hypoplasia of the thymus (HP:0000778)	1.83235739
75	Glycosuria (HP:0003076)	1.82998242
76	Abnormality of urine glucose concentration (HP:0011016)	1.82998242
77	Obsessive-compulsive behavior (HP:0000722)	1.82890678
78	Abnormality of potassium homeostasis (HP:0011042)	1.82072669
79	Progressive sensorineural hearing impairment (HP:0000408)	1.80407392
80	Asymmetric septal hypertrophy (HP:0001670)	1.79911079
81	Hypoplastic ischia (HP:0003175)	1.79445469
82	Spastic paraparesis (HP:0002313)	1.79197268
83	Stage 5 chronic kidney disease (HP:0003774)	1.78103650
84	Cerebral hypomyelination (HP:0006808)	1.76511863
85	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.72627174
86	Distal upper limb amyotrophy (HP:0007149)	1.72120733
87	Upper limb amyotrophy (HP:0009129)	1.72120733
88	Increased purine levels (HP:0004368)	1.71984945
89	Hyperuricemia (HP:0002149)	1.71984945
90	Progressive hearing impairment (HP:0001730)	1.71841031
91	Abnormality of the gallbladder (HP:0005264)	1.71248450
92	Peripheral hypomyelination (HP:0007182)	1.71093380
93	Insulin-resistant diabetes mellitus (HP:0000831)	1.70784049
94	Subcapsular cataract (HP:0000523)	1.70735229
95	Abnormality of dental color (HP:0011073)	1.69609145
96	Truncal obesity (HP:0001956)	1.68693266
97	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.67977509
98	Absent epiphyses (HP:0010577)	1.67977509
99	Septate vagina (HP:0001153)	1.67367402
100	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.66176932

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.18718336
2	TESK1	4.73404648
3	PNCK	4.26145290
4	AKT3	3.99749908
5	DDR2	2.83581532
6	CDK12	2.61358103
7	BRAF	2.46588809
8	PDK2	2.15144306
9	STK38	2.09239773
10	PBK	2.00252076
11	PLK2	1.98728323
12	INSRR	1.98609952
13	KSR2	1.83938627
14	MAP4K2	1.82782964
15	WNK4	1.68423621
16	MAP3K2	1.64669545
17	CAMK1G	1.60899748
18	CDK7	1.60483057
19	TTK	1.59064981
20	MET	1.57348070
21	EIF2AK1	1.57094375
22	MAPK15	1.52929142
23	MST1R	1.52578495
24	EPHA2	1.47267810
25	BRD4	1.37207872
26	STK38L	1.37148325
27	PRKD3	1.29373056
28	MAP3K8	1.28498032
29	MST4	1.25095183
30	TESK2	1.24986064
31	WNK1	1.20968302
32	NEK6	1.18694497
33	PDPK1	1.17449292
34	SRPK1	1.17365167
35	NEK1	1.16938911
36	RIPK4	1.15136762
37	MAP3K9	1.13299611
38	BMX	1.13040357
39	WEE1	1.09583185
40	RPS6KB2	1.05846542
41	ERBB4	1.01319062
42	CHEK1	0.97768841
43	TRIB3	0.97343916
44	CDK19	0.96163650
45	PTK2B	0.94926775
46	LATS2	0.91934065
47	MAP2K2	0.89563755
48	PDK1	0.81407329
49	AURKA	0.79932035
50	NME1	0.79091072
51	IRAK3	0.77191773
52	VRK2	0.77059662
53	ARAF	0.75388756
54	BUB1	0.72950106
55	CDK2	0.69811613
56	CDK4	0.68292636
57	CDK1	0.67397072
58	TSSK6	0.67362642
59	PRKCI	0.66924531
60	BRSK1	0.66343856
61	PLK1	0.62748585
62	NEK2	0.62474257
63	MTOR	0.61536108
64	LATS1	0.59202161
65	OXSR1	0.58378007
66	PINK1	0.55616449
67	CDK3	0.55191924
68	DYRK3	0.52177961
69	NME2	0.50488655
70	ILK	0.49788624
71	GSK3B	0.48472998
72	AURKB	0.48331261
73	STK39	0.48198656
74	RPS6KA1	0.46520443
75	PIK3CG	0.44854784
76	CHEK2	0.44713837
77	PRKG2	0.43830647
78	PKN2	0.43657522
79	PAK1	0.42758981
80	SGK1	0.41933288
81	ATM	0.40253215
82	ICK	0.38412416
83	NTRK3	0.37596971
84	ATR	0.37066268
85	MAP3K1	0.34039186
86	CSNK2A2	0.33243899
87	RAF1	0.32914949
88	PRKG1	0.32867136
89	LRRK2	0.31817999
90	MAPK1	0.30678538
91	DYRK1B	0.30517006
92	CSNK1E	0.30168741
93	VRK1	0.30023727
94	RET	0.29157294
95	CAMK1	0.28466015
96	AKT2	0.28437405
97	STK16	0.27221312
98	ROCK1	0.26830128
99	BRSK2	0.26643378
100	CCNB1	0.25801268

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.07200774
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.95402442
3	RNA transport_Homo sapiens_hsa03013	3.09608475
4	Phenylalanine metabolism_Homo sapiens_hsa00360	3.07876684
5	Homologous recombination_Homo sapiens_hsa03440	2.47680183
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.35688792
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.31756329
8	Mismatch repair_Homo sapiens_hsa03430	2.31459123
9	DNA replication_Homo sapiens_hsa03030	2.11890965
10	Sulfur relay system_Homo sapiens_hsa04122	2.04919220
11	Basal transcription factors_Homo sapiens_hsa03022	2.00151356
12	Tyrosine metabolism_Homo sapiens_hsa00350	2.00055894
13	Olfactory transduction_Homo sapiens_hsa04740	2.00040697
14	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.92119207
15	mRNA surveillance pathway_Homo sapiens_hsa03015	1.91368255
16	Arginine biosynthesis_Homo sapiens_hsa00220	1.85169728
17	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.82818142
18	Ribosome_Homo sapiens_hsa03010	1.75215301
19	Butanoate metabolism_Homo sapiens_hsa00650	1.74230775
20	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.66822669
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.65430835
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.63113439
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56843910
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53149741
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.52766602
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.52547592
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.45395729
28	Folate biosynthesis_Homo sapiens_hsa00790	1.43003356
29	Oocyte meiosis_Homo sapiens_hsa04114	1.38121461
30	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.35316680
31	Huntingtons disease_Homo sapiens_hsa05016	1.34367662
32	Cell cycle_Homo sapiens_hsa04110	1.33401752
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.33275974
34	One carbon pool by folate_Homo sapiens_hsa00670	1.33141718
35	Spliceosome_Homo sapiens_hsa03040	1.29879509
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.26770968
37	Carbon metabolism_Homo sapiens_hsa01200	1.26742618
38	Base excision repair_Homo sapiens_hsa03410	1.26501953
39	RNA polymerase_Homo sapiens_hsa03020	1.17101472
40	Fatty acid degradation_Homo sapiens_hsa00071	1.07735723
41	Proteasome_Homo sapiens_hsa03050	1.07576130
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06620420
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.05992957
44	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.04282979
45	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.03711646
46	Thyroid cancer_Homo sapiens_hsa05216	1.01088104
47	Purine metabolism_Homo sapiens_hsa00230	0.95074578
48	Parkinsons disease_Homo sapiens_hsa05012	0.93625248
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.93567904
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93434836
51	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.93096500
52	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89579528
53	Oxidative phosphorylation_Homo sapiens_hsa00190	0.86431186
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83624955
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.82488395
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78943444
57	Propanoate metabolism_Homo sapiens_hsa00640	0.78425931
58	Taste transduction_Homo sapiens_hsa04742	0.76727694
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.75673303
60	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75279319
61	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73973720
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.71862130
63	Peroxisome_Homo sapiens_hsa04146	0.68120527
64	Metabolic pathways_Homo sapiens_hsa01100	0.67213902
65	Glutathione metabolism_Homo sapiens_hsa00480	0.66299844
66	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.65099145
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.64141368
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.60099797
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59468768
70	RNA degradation_Homo sapiens_hsa03018	0.58959015
71	Retinol metabolism_Homo sapiens_hsa00830	0.57177940
72	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55743503
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.54848436
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54724103
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.54347679
76	Histidine metabolism_Homo sapiens_hsa00340	0.52627708
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52313470
78	Fatty acid elongation_Homo sapiens_hsa00062	0.49892764
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49040647
80	mTOR signaling pathway_Homo sapiens_hsa04150	0.48381828
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47072034
82	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46360890
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46297737
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44130644
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40417323
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39817476
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.39680123
88	Galactose metabolism_Homo sapiens_hsa00052	0.37032799
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35228366
90	Insulin signaling pathway_Homo sapiens_hsa04910	0.34652585
91	Endocytosis_Homo sapiens_hsa04144	0.34520394
92	Viral carcinogenesis_Homo sapiens_hsa05203	0.34489472
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.34230569
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34170060
95	ErbB signaling pathway_Homo sapiens_hsa04012	0.34098660
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32063763
97	VEGF signaling pathway_Homo sapiens_hsa04370	0.31752748
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30765294
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.29197627
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27844397

VCX3B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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