VDAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.02327386
2cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.97788447
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.94958172
4nuclear pore organization (GO:0006999)4.77980834
5plasma membrane repair (GO:0001778)4.74457175
6Golgi transport vesicle coating (GO:0048200)4.70165272
7COPI coating of Golgi vesicle (GO:0048205)4.70165272
8regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.66940596
9negative regulation of potassium ion transmembrane transport (GO:1901380)4.66721735
10ribosome assembly (GO:0042255)4.66333403
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.63920263
12NADH metabolic process (GO:0006734)4.57229860
13sarcomere organization (GO:0045214)4.56721391
14establishment of integrated proviral latency (GO:0075713)4.56461222
15cell communication by electrical coupling (GO:0010644)4.55082888
16nuclear pore complex assembly (GO:0051292)4.38365142
17regulation of cofactor metabolic process (GO:0051193)4.34772324
18regulation of coenzyme metabolic process (GO:0051196)4.34772324
19regulation of acyl-CoA biosynthetic process (GO:0050812)4.30602586
20cardiac myofibril assembly (GO:0055003)4.23286647
21lysine catabolic process (GO:0006554)4.21382472
22lysine metabolic process (GO:0006553)4.21382472
23IMP metabolic process (GO:0046040)4.17966821
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.16816260
25muscle filament sliding (GO:0030049)4.16804635
26actin-myosin filament sliding (GO:0033275)4.16804635
27cardiac muscle contraction (GO:0060048)4.13420153
28IMP biosynthetic process (GO:0006188)4.13337933
29nucleobase-containing small molecule interconversion (GO:0015949)4.12636312
30cell communication involved in cardiac conduction (GO:0086065)4.10487001
31DNA unwinding involved in DNA replication (GO:0006268)4.10073883
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.05643307
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.04879728
34formation of translation preinitiation complex (GO:0001731)4.04848405
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.02813836
36oxaloacetate metabolic process (GO:0006107)4.02177664
37mitotic metaphase plate congression (GO:0007080)4.02156237
38sodium ion export (GO:0071436)4.01471426
39regulation of translational fidelity (GO:0006450)3.89174793
402-oxoglutarate metabolic process (GO:0006103)3.86688779
41carnitine shuttle (GO:0006853)3.84340540
42regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.80364654
43aspartate family amino acid catabolic process (GO:0009068)3.78508794
44synaptic vesicle maturation (GO:0016188)3.77311403
45myofibril assembly (GO:0030239)3.63402034
46regulation of membrane repolarization (GO:0060306)3.62744705
47regulation of skeletal muscle contraction (GO:0014819)3.62250640
48mitotic chromosome condensation (GO:0007076)3.61785287
49synaptic vesicle docking involved in exocytosis (GO:0016081)3.56913808
50establishment of viral latency (GO:0019043)3.53700659
51folic acid-containing compound biosynthetic process (GO:0009396)3.50374132
52succinate metabolic process (GO:0006105)3.50193625
53striated muscle contraction (GO:0006941)3.49882024
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49226935
55tricarboxylic acid metabolic process (GO:0072350)3.46275451
56ventricular cardiac muscle cell action potential (GO:0086005)3.45507605
57DNA strand elongation involved in DNA replication (GO:0006271)3.44642813
58cellular potassium ion homeostasis (GO:0030007)3.41415825
59gluconeogenesis (GO:0006094)3.36733549
60tRNA aminoacylation for protein translation (GO:0006418)3.36311320
61proline biosynthetic process (GO:0006561)3.36174578
62oxidative phosphorylation (GO:0006119)3.35386685
63sarcoplasmic reticulum calcium ion transport (GO:0070296)3.34854154
64DNA strand elongation (GO:0022616)3.33773741
65glycolytic process (GO:0006096)3.33365722
66regulation of sulfur metabolic process (GO:0042762)3.33358305
67regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32086681
68protein localization to chromosome, centromeric region (GO:0071459)3.28250742
69tRNA aminoacylation (GO:0043039)3.27143698
70amino acid activation (GO:0043038)3.27143698
71actin-mediated cell contraction (GO:0070252)3.26955456
72regulation of translational termination (GO:0006449)3.26692525
73membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.25722903
74fatty acid transmembrane transport (GO:1902001)3.25268811
75regulation of synapse structural plasticity (GO:0051823)3.24271612
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23090489
77protein complex localization (GO:0031503)3.20634421
78regulation of mitotic spindle organization (GO:0060236)3.20056467
79mitotic sister chromatid segregation (GO:0000070)3.19754359
80metaphase plate congression (GO:0051310)3.19652482
81pore complex assembly (GO:0046931)3.19280602
82cardiac muscle cell development (GO:0055013)3.18553989
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18036409
84cellular protein complex localization (GO:0034629)3.14996534
85cardiac muscle cell action potential involved in contraction (GO:0086002)3.14129415
86mitotic nuclear envelope disassembly (GO:0007077)3.13680244
87protein localization to kinetochore (GO:0034501)3.12033943
88cardiac muscle cell action potential (GO:0086001)3.11818555
89glutamate secretion (GO:0014047)3.11601169
90actomyosin structure organization (GO:0031032)3.10896559
91hexose biosynthetic process (GO:0019319)3.09487483
92protein maturation by protein folding (GO:0022417)3.08785616
93negative regulation of cell size (GO:0045792)3.06990823
94activation of protein kinase A activity (GO:0034199)3.05189230
95regulation of cell communication by electrical coupling (GO:0010649)3.04934586
96purine nucleobase biosynthetic process (GO:0009113)3.01578740
97telomere maintenance via semi-conservative replication (GO:0032201)2.98937707
98synaptic vesicle exocytosis (GO:0016079)2.98814055
99AMP metabolic process (GO:0046033)2.97105272
100pyruvate metabolic process (GO:0006090)2.96970584
101sister chromatid segregation (GO:0000819)2.95733947
102membrane disassembly (GO:0030397)2.95698970
103nuclear envelope disassembly (GO:0051081)2.95698970
104regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95606247
105membrane repolarization (GO:0086009)2.95502767
106negative regulation of potassium ion transport (GO:0043267)2.95410302
107regulation of calcium ion transmembrane transport (GO:1903169)2.93614553
108regulation of calcium ion transmembrane transporter activity (GO:1901019)2.93614553
109positive regulation of synapse maturation (GO:0090129)2.93447796
110cardiac cell development (GO:0055006)2.91705737
111cardiac conduction (GO:0061337)2.90856657
112COPII vesicle coating (GO:0048208)2.90698446
113dicarboxylic acid biosynthetic process (GO:0043650)2.90326551
114regulation of heart rate by cardiac conduction (GO:0086091)2.90207970
115regulation of potassium ion transmembrane transporter activity (GO:1901016)2.89915804
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88528757
117double-strand break repair via nonhomologous end joining (GO:0006303)2.87178243
118non-recombinational repair (GO:0000726)2.87178243
119membrane repolarization during action potential (GO:0086011)2.87140314
120cardiac muscle hypertrophy (GO:0003300)2.85826161
121carnitine transport (GO:0015879)2.83049059
122amino-acid betaine transport (GO:0015838)2.83049059
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82672806
124layer formation in cerebral cortex (GO:0021819)2.81773238
125locomotory exploration behavior (GO:0035641)2.80409572
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.78177372
127L-serine metabolic process (GO:0006563)2.77764330
128carnitine transmembrane transport (GO:1902603)2.77488154
129regulation of actin filament-based movement (GO:1903115)2.77388829
130deoxyribonucleotide biosynthetic process (GO:0009263)2.77291889
131positive regulation of sodium ion transport (GO:0010765)2.77097541
132pteridine-containing compound biosynthetic process (GO:0042559)2.76682583
133positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75980479
134nucleotide-sugar biosynthetic process (GO:0009226)2.75589640
135striated muscle hypertrophy (GO:0014897)2.75386224
136monosaccharide biosynthetic process (GO:0046364)2.74881681
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74692611
138peptidyl-arginine omega-N-methylation (GO:0035247)2.73527602
139regulation of spindle organization (GO:0090224)2.73017455
140establishment of chromosome localization (GO:0051303)2.71805431
141potassium ion import (GO:0010107)2.71588983
142positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71131791
143regulation of sodium ion transmembrane transporter activity (GO:2000649)2.69701091
144nucleobase biosynthetic process (GO:0046112)2.69632667
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69004062
146proteasome assembly (GO:0043248)2.67910835
147regulation of potassium ion transmembrane transport (GO:1901379)2.67896994
148maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67339585
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66957244
150tetrahydrofolate metabolic process (GO:0046653)2.65274441
151de novo protein folding (GO:0006458)2.65193536
152phosphate ion transmembrane transport (GO:0035435)2.62499299
153phosphate ion transport (GO:0006817)2.62166033
154ribosome biogenesis (GO:0042254)2.61428652
155ventricular cardiac muscle cell development (GO:0055015)2.61255410
156positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.61101705
157regulation of mitochondrial translation (GO:0070129)2.60541526
158DNA replication initiation (GO:0006270)2.59115355
159glycogen catabolic process (GO:0005980)2.58406280
160mitochondrial fusion (GO:0008053)2.58342087
161negative regulation of microtubule polymerization (GO:0031115)2.57487480
162neurotransmitter secretion (GO:0007269)2.57378265
163ribosomal large subunit biogenesis (GO:0042273)2.56780600
164mitotic sister chromatid cohesion (GO:0007064)2.56203072
165negative regulation of ligase activity (GO:0051352)2.55708533
166negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55708533
167positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55535889
168regulation of translational elongation (GO:0006448)2.54246590
169protein retention in ER lumen (GO:0006621)2.54048119
170de novo posttranslational protein folding (GO:0051084)2.51571927
1714-hydroxyproline metabolic process (GO:0019471)2.51229466
172nucleoside diphosphate biosynthetic process (GO:0009133)2.48771422
173nuclear envelope organization (GO:0006998)2.47376929
174vesicle coating (GO:0006901)2.46888144
175positive regulation of chromosome segregation (GO:0051984)2.45481188
176glutamine metabolic process (GO:0006541)2.42316075
177telomere maintenance via recombination (GO:0000722)2.40846243
178peptidyl-arginine methylation (GO:0018216)2.34359888
179peptidyl-arginine N-methylation (GO:0035246)2.34359888
180NADPH regeneration (GO:0006740)2.34130020
181mitotic nuclear envelope reassembly (GO:0007084)2.34031960
182nuclear envelope reassembly (GO:0031468)2.34031960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93411530
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.17504579
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14167894
4ZNF263_19887448_ChIP-Seq_K562_Human3.34536451
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24071493
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.21535386
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10647220
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.89256619
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87321877
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.82651046
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80797410
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80029085
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.75179543
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.72671853
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.60521230
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59732666
17* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.48782113
18* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48600834
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46893688
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44439900
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40723494
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30944828
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30067592
24* RARB_27405468_Chip-Seq_BRAIN_Mouse2.28960765
25DCP1A_22483619_ChIP-Seq_HELA_Human2.27683824
26* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19897721
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19424989
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.17510180
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14145800
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.14112005
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12400138
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10580297
33XRN2_22483619_ChIP-Seq_HELA_Human2.08293345
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.05563054
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03601617
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98541230
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89681952
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87684231
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86048833
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85116535
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.83193993
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77939009
43CLOCK_20551151_ChIP-Seq_293T_Human1.77833280
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77365469
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.77319118
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76720820
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76164521
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74857670
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71679929
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70017885
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66631013
52TTF2_22483619_ChIP-Seq_HELA_Human1.66436753
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65054875
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.61102858
55GABP_19822575_ChIP-Seq_HepG2_Human1.61082839
56* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60400477
57* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57592905
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56661632
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.55477596
60* LXR_22292898_ChIP-Seq_THP-1_Human1.54145195
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.52840691
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52445302
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52087491
64ATF3_27146783_Chip-Seq_COLON_Human1.49774977
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.45419374
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.45419374
67ELK1_19687146_ChIP-ChIP_HELA_Human1.45158692
68* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44515794
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43862805
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.41120391
71DROSHA_22980978_ChIP-Seq_HELA_Human1.40934522
72P68_20966046_ChIP-Seq_HELA_Human1.39138063
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38847848
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37890421
75RACK7_27058665_Chip-Seq_MCF-7_Human1.37801001
76* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37748437
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.36385548
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36088808
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35813149
80CREB1_26743006_Chip-Seq_LNCaP_Human1.35357814
81KDM2B_26808549_Chip-Seq_K562_Human1.33502679
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.33254422
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33163085
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32461429
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.31378556
86* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31244541
87TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.29919421
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29899530
89KDM2B_26808549_Chip-Seq_DND41_Human1.29094291
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27477492
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27250733
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27129647
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.25441619
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.25209066
95CTCF_27219007_Chip-Seq_Bcells_Human1.24433819
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23690701
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.21831797
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21408972
99* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19415370
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19281470
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19207593
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19166572
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19160446
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17498252
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17458356
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16990234
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16713159
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16671624
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16200034
110MYC_22102868_ChIP-Seq_BL_Human1.15083889
111FOXP3_21729870_ChIP-Seq_TREG_Human1.13422059
112SMC4_20622854_ChIP-Seq_HELA_Human1.13374770
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12398224
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12156880
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11734407
116MYC_18555785_ChIP-Seq_MESCs_Mouse1.11242475
117* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11241412
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10901361
119* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10647247
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10593672
121TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10591188
122* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10107266
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.10061962
124EZH2_22144423_ChIP-Seq_EOC_Human1.09514422
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09257191
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09158244
127ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08580974
128* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08095523
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08094410
130YY1_21170310_ChIP-Seq_MESCs_Mouse1.07894064
131MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07767143
132RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07711207
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07680097
134* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07504704
135REST_21632747_ChIP-Seq_MESCs_Mouse1.06974238
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06930318
137NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05964878
138EGR1_19374776_ChIP-ChIP_THP-1_Human1.05830899
139TFEB_21752829_ChIP-Seq_HELA_Human1.05085422
140ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04876970
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03207147
142CHD1_26751641_Chip-Seq_LNCaP_Human1.02384338
143KDM5A_27292631_Chip-Seq_BREAST_Human1.02236269
144* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02008005
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01776422
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00889015
147* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00487316
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99973666
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99682599
150THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99272767
151CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98043944
152VDR_23849224_ChIP-Seq_CD4+_Human0.97864728
153* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96913200
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96844233
155* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94734949
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.94718164
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94355100
158AR_21909140_ChIP-Seq_LNCAP_Human0.94004647
159* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93875048
160ZNF274_21170338_ChIP-Seq_K562_Hela0.93589289
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93517197
162CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93494601
163GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93359002
164RXR_22158963_ChIP-Seq_LIVER_Mouse0.92380793
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92299717
166ELK3_25401928_ChIP-Seq_HUVEC_Human0.90175340
167POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90135450
168TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89887743
169TP63_22573176_ChIP-Seq_HFKS_Human0.89472106
170FOXP1_21924763_ChIP-Seq_HESCs_Human0.88073426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.24393121
2MP0000751_myopathy4.21998631
3MP0002837_dystrophic_cardiac_calcinosis4.13462364
4MP0004084_abnormal_cardiac_muscle3.99283142
5MP0004215_abnormal_myocardial_fiber3.23763665
6MP0004957_abnormal_blastocyst_morpholog3.19849149
7MP0004859_abnormal_synaptic_plasticity3.19831206
8MP0004036_abnormal_muscle_relaxation3.17113974
9MP0010094_abnormal_chromosome_stability3.16617301
10MP0003693_abnormal_embryo_hatching2.93174796
11MP0000749_muscle_degeneration2.84360355
12MP0003111_abnormal_nucleus_morphology2.80640676
13MP0003941_abnormal_skin_development2.77122177
14MP0004233_abnormal_muscle_weight2.76750082
15MP0004145_abnormal_muscle_electrophysio2.70845309
16MP0002877_abnormal_melanocyte_morpholog2.69417920
17MP0005451_abnormal_body_composition2.52133468
18MP0002269_muscular_atrophy2.45436208
19MP0004087_abnormal_muscle_fiber2.45036286
20MP0005330_cardiomyopathy2.44544118
21MP0003077_abnormal_cell_cycle2.39027239
22MP0004130_abnormal_muscle_cell2.37739867
23MP0000747_muscle_weakness2.33568460
24MP0008932_abnormal_embryonic_tissue2.24425280
25MP0005620_abnormal_muscle_contractility2.16474861
26MP0000750_abnormal_muscle_regeneration2.11316850
27MP0003950_abnormal_plasma_membrane2.08889937
28MP0002106_abnormal_muscle_physiology2.02961508
29MP0008775_abnormal_heart_ventricle1.99311151
30MP0002972_abnormal_cardiac_muscle1.97803590
31MP0008438_abnormal_cutaneous_collagen1.96699949
32MP0003705_abnormal_hypodermis_morpholog1.96420528
33MP0003137_abnormal_impulse_conducting1.92110821
34MP0008058_abnormal_DNA_repair1.91243665
35MP0009697_abnormal_copulation1.87178561
36MP0000759_abnormal_skeletal_muscle1.82320873
37MP0003806_abnormal_nucleotide_metabolis1.78381232
38MP0004272_abnormal_basement_membrane1.74430029
39MP0001661_extended_life_span1.72390587
40MP0002822_catalepsy1.70033203
41MP0004270_analgesia1.68427093
42MP0008007_abnormal_cellular_replicative1.67935488
43MP0006036_abnormal_mitochondrial_physio1.65699285
44MP0005369_muscle_phenotype1.64532304
45MP0004043_abnormal_pH_regulation1.62997966
46MP0003221_abnormal_cardiomyocyte_apopto1.61855545
47* MP0003635_abnormal_synaptic_transmissio1.61428506
48MP0010630_abnormal_cardiac_muscle1.60718805
49MP0004484_altered_response_of1.60241043
50MP0001544_abnormal_cardiovascular_syste1.59382374
51MP0005385_cardiovascular_system_phenoty1.59382374
52MP0000350_abnormal_cell_proliferation1.57397870
53MP0004858_abnormal_nervous_system1.55006275
54MP0008057_abnormal_DNA_replication1.54216947
55MP0004085_abnormal_heartbeat1.45478539
56MP0006138_congestive_heart_failure1.44532292
57MP0005380_embryogenesis_phenotype1.40782905
58MP0001672_abnormal_embryogenesis/_devel1.40782905
59MP0002909_abnormal_adrenal_gland1.36833666
60MP0001697_abnormal_embryo_size1.34702513
61MP0006035_abnormal_mitochondrial_morpho1.34290193
62* MP0002080_prenatal_lethality1.34197022
63MP0009672_abnormal_birth_weight1.32095373
64MP0008961_abnormal_basal_metabolism1.30710704
65MP0002332_abnormal_exercise_endurance1.25121850
66* MP0002063_abnormal_learning/memory/cond1.22312049
67MP0003283_abnormal_digestive_organ1.20249119
68MP0009046_muscle_twitch1.19924606
69MP0005257_abnormal_intraocular_pressure1.19135652
70MP0010234_abnormal_vibrissa_follicle1.17826520
71MP0010030_abnormal_orbit_morphology1.16079805
72MP0002653_abnormal_ependyma_morphology1.15329533
73MP0005666_abnormal_adipose_tissue1.13693947
74MP0005165_increased_susceptibility_to1.12505652
75MP0002796_impaired_skin_barrier1.11918381
76MP0005501_abnormal_skin_physiology1.10811473
77MP0000762_abnormal_tongue_morphology1.10217059
78MP0005266_abnormal_metabolism1.09491620
79MP0003123_paternal_imprinting1.08785724
80MP0009745_abnormal_behavioral_response1.08725916
81MP0005623_abnormal_meninges_morphology1.07435723
82MP0002064_seizures1.06664625
83MP0003718_maternal_effect1.05807193
84MP0000490_abnormal_crypts_of1.03828406
85MP0000579_abnormal_nail_morphology1.03806862
86MP0009780_abnormal_chondrocyte_physiolo1.02599962
87MP0002234_abnormal_pharynx_morphology1.00371731
88MP0002084_abnormal_developmental_patter1.00104287
89MP0002085_abnormal_embryonic_tissue0.99515864
90MP0003186_abnormal_redox_activity0.97563566
91MP0003329_amyloid_beta_deposits0.96254640
92MP0002060_abnormal_skin_morphology0.95978772
93MP0002127_abnormal_cardiovascular_syste0.95692283
94MP0000013_abnormal_adipose_tissue0.95272214
95MP0005187_abnormal_penis_morphology0.95152283
96MP0001346_abnormal_lacrimal_gland0.94308695
97MP0003567_abnormal_fetal_cardiomyocyte0.94059609
98MP0002086_abnormal_extraembryonic_tissu0.94024036
99MP0003315_abnormal_perineum_morphology0.92999746
100MP0004811_abnormal_neuron_physiology0.92101228
101MP0010352_gastrointestinal_tract_polyps0.91321554
102MP0002734_abnormal_mechanical_nocicepti0.89387186
103MP0001299_abnormal_eye_distance/0.86374689
104MP0004197_abnormal_fetal_growth/weight/0.85844808
105MP0004185_abnormal_adipocyte_glucose0.85680435
106MP0000313_abnormal_cell_death0.84846182
107MP0001529_abnormal_vocalization0.83893248
108MP0003566_abnormal_cell_adhesion0.81590393
109MP0005332_abnormal_amino_acid0.80505007
110MP0000462_abnormal_digestive_system0.80266663
111MP0005360_urolithiasis0.79747033
112MP0003786_premature_aging0.79602643
113MP0005375_adipose_tissue_phenotype0.79021384
114MP0004924_abnormal_behavior0.78685474
115MP0005386_behavior/neurological_phenoty0.78685474
116MP0000266_abnormal_heart_morphology0.78420895
117MP0001968_abnormal_touch/_nociception0.77196432
118MP0008569_lethality_at_weaning0.76588405
119MP0005408_hypopigmentation0.75626415
120MP0003385_abnormal_body_wall0.74874381
121MP0005384_cellular_phenotype0.74727386
122MP0001730_embryonic_growth_arrest0.74427255
123MP0002108_abnormal_muscle_morphology0.74141327
124MP0001849_ear_inflammation0.73492129
125MP0002272_abnormal_nervous_system0.72834117
126MP0000733_abnormal_muscle_development0.72105188
127MP0001727_abnormal_embryo_implantation0.71233504
128MP0002089_abnormal_postnatal_growth/wei0.71130585
129MP0002572_abnormal_emotion/affect_behav0.71128030
130MP0000534_abnormal_ureter_morphology0.70630112
131MP0005621_abnormal_cell_physiology0.69399073
132MP0002697_abnormal_eye_size0.68576443
133MP0004885_abnormal_endolymph0.65909577
134MP0010307_abnormal_tumor_latency0.65512173
135MP0001440_abnormal_grooming_behavior0.65335459
136MP0001915_intracranial_hemorrhage0.64782348
137MP0000358_abnormal_cell_content/0.64047730
138MP0002066_abnormal_motor_capabilities/c0.62919072
139MP0003984_embryonic_growth_retardation0.60376963
140MP0000003_abnormal_adipose_tissue0.60172074
141MP0000955_abnormal_spinal_cord0.59935547
142MP0002733_abnormal_thermal_nociception0.59770460
143MP0002067_abnormal_sensory_capabilities0.59607656
144MP0002735_abnormal_chemical_nociception0.59248505
145MP0005584_abnormal_enzyme/coenzyme_acti0.58871886
146MP0002088_abnormal_embryonic_growth/wei0.58787780
147MP0003880_abnormal_central_pattern0.58328986
148MP0005670_abnormal_white_adipose0.58171558
149MP0003122_maternal_imprinting0.57354332
150MP0003879_abnormal_hair_cell0.57199887
151MP0000537_abnormal_urethra_morphology0.56789224
152MP0005319_abnormal_enzyme/_coenzyme0.56432227
153MP0002078_abnormal_glucose_homeostasis0.55728043

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)5.67010600
2Exercise-induced myalgia (HP:0003738)5.11777352
3Sudden death (HP:0001699)4.78227832
4Myoglobinuria (HP:0002913)4.49440310
5Abnormal gallbladder physiology (HP:0012438)3.84963125
6Cholecystitis (HP:0001082)3.84963125
7Calf muscle hypertrophy (HP:0008981)3.70332233
8Muscle hypertrophy of the lower extremities (HP:0008968)3.51907295
9Muscle fiber splitting (HP:0003555)3.48397357
10Hyporeflexia of lower limbs (HP:0002600)3.40827849
11Rhabdomyolysis (HP:0003201)3.37058790
12Abnormality of the calf musculature (HP:0001430)3.35655488
13Ventricular tachycardia (HP:0004756)3.33993322
14Myotonia (HP:0002486)3.21636048
15Progressive muscle weakness (HP:0003323)3.18485824
16Ventricular fibrillation (HP:0001663)3.16830969
17Difficulty running (HP:0009046)3.16280532
18Muscle fiber inclusion bodies (HP:0100299)3.14518780
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.14462109
20Bundle branch block (HP:0011710)3.09906758
21Increased connective tissue (HP:0009025)3.08290244
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.02153481
23EMG: myopathic abnormalities (HP:0003458)3.01959472
24Atrial fibrillation (HP:0005110)3.00035171
25Type 1 muscle fiber predominance (HP:0003803)2.99312819
26Palpitations (HP:0001962)2.99011255
27Right ventricular cardiomyopathy (HP:0011663)2.97894376
28Primary atrial arrhythmia (HP:0001692)2.92332864
29Dysmetric saccades (HP:0000641)2.85395100
30Supraventricular tachycardia (HP:0004755)2.84885458
31Myokymia (HP:0002411)2.84149166
32Supraventricular arrhythmia (HP:0005115)2.80588018
33Difficulty climbing stairs (HP:0003551)2.79250850
34Ventricular arrhythmia (HP:0004308)2.75630271
35Gout (HP:0001997)2.75466995
36Syncope (HP:0001279)2.75083165
37Multiple enchondromatosis (HP:0005701)2.74827514
38Subaortic stenosis (HP:0001682)2.70609476
39Abnormality of the left ventricular outflow tract (HP:0011103)2.70609476
40Muscle stiffness (HP:0003552)2.70545228
41Ketoacidosis (HP:0001993)2.64578039
42Pheochromocytoma (HP:0002666)2.62061809
43Asymmetric septal hypertrophy (HP:0001670)2.58533039
44Visual hallucinations (HP:0002367)2.55029547
45Nemaline bodies (HP:0003798)2.53748361
46Prolonged QT interval (HP:0001657)2.53096075
47Abnormality of the lower motor neuron (HP:0002366)2.49632094
48Premature rupture of membranes (HP:0001788)2.48714792
49Microvesicular hepatic steatosis (HP:0001414)2.47521837
50Neck muscle weakness (HP:0000467)2.45039786
51Limb-girdle muscle atrophy (HP:0003797)2.44812002
52Lipoatrophy (HP:0100578)2.43303800
53Calcaneovalgus deformity (HP:0001848)2.41649656
54Hamartoma of the eye (HP:0010568)2.40979452
55Heart block (HP:0012722)2.40575185
56Myopathic facies (HP:0002058)2.37631167
57Atrioventricular block (HP:0001678)2.37410206
58Adenoma sebaceum (HP:0009720)2.36977639
59Angiofibromas (HP:0010615)2.36977639
60Resting tremor (HP:0002322)2.36053762
61Distal lower limb amyotrophy (HP:0008944)2.34745904
62Distal arthrogryposis (HP:0005684)2.33707003
63Progressive external ophthalmoplegia (HP:0000590)2.32969527
64Increased variability in muscle fiber diameter (HP:0003557)2.30731326
65Abnormal atrioventricular conduction (HP:0005150)2.25446482
66Ependymoma (HP:0002888)2.24033186
67Conjunctival hamartoma (HP:0100780)2.22478003
68Neuroendocrine neoplasm (HP:0100634)2.20914180
69Abnormality of skeletal muscle fiber size (HP:0012084)2.20274590
70Ragged-red muscle fibers (HP:0003200)2.19587361
71Neoplasm of the peripheral nervous system (HP:0100007)2.19503497
72Shoulder girdle muscle weakness (HP:0003547)2.18688046
73Deformed tarsal bones (HP:0008119)2.18021064
74EMG: neuropathic changes (HP:0003445)2.17371163
75Insidious onset (HP:0003587)2.17341918
76Termporal pattern (HP:0011008)2.17341918
77Central scotoma (HP:0000603)2.14842955
78Exercise intolerance (HP:0003546)2.11629239
79Dilated cardiomyopathy (HP:0001644)2.11026025
80Abnormal EKG (HP:0003115)2.10555356
81Abnormality of the umbilical cord (HP:0010881)2.08701691
82Neoplasm of the adrenal gland (HP:0100631)2.06513771
83Athetosis (HP:0002305)2.03957949
84Trismus (HP:0000211)2.03876886
85Ketosis (HP:0001946)2.03067430
86Abnormalities of placenta or umbilical cord (HP:0001194)2.02563571
87Abnormality of placental membranes (HP:0011409)2.02363329
88Amniotic constriction ring (HP:0009775)2.02363329
89Hyperglycinuria (HP:0003108)2.00366886
90Round ear (HP:0100830)1.99037226
91Impaired social interactions (HP:0000735)1.97416031
92Abnormal social behavior (HP:0012433)1.97416031
93Ulnar deviation of the wrist (HP:0003049)1.96039843
94Mildly elevated creatine phosphokinase (HP:0008180)1.95734944
95Astrocytoma (HP:0009592)1.94725362
96Abnormality of the astrocytes (HP:0100707)1.94725362
97Focal motor seizures (HP:0011153)1.94665367
98Microglossia (HP:0000171)1.94415530
99Achilles tendon contracture (HP:0001771)1.93043256
100Rimmed vacuoles (HP:0003805)1.91515931
101Poor eye contact (HP:0000817)1.90396251
102Distal lower limb muscle weakness (HP:0009053)1.90185194
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90142535
104Abnormality of alanine metabolism (HP:0010916)1.90142535
105Hyperalaninemia (HP:0003348)1.90142535
106Cortical dysplasia (HP:0002539)1.90077217
107Increased purine levels (HP:0004368)1.90037779
108Hyperuricemia (HP:0002149)1.90037779
109Lymphangioma (HP:0100764)1.89692277
110Breech presentation (HP:0001623)1.89676664
111Urinary urgency (HP:0000012)1.89641079
112Pelvic girdle muscle weakness (HP:0003749)1.89479946
113Upper limb amyotrophy (HP:0009129)1.88789540
114Distal upper limb amyotrophy (HP:0007149)1.88789540
115Lower limb amyotrophy (HP:0007210)1.88404511
116Abnormality of the Achilles tendon (HP:0005109)1.88057882
117Impaired vibration sensation in the lower limbs (HP:0002166)1.87562358
118Areflexia of lower limbs (HP:0002522)1.87046653
119Abnormality of the calcaneus (HP:0008364)1.86738081
120Pterygium (HP:0001059)1.85050526
121Hyperammonemia (HP:0001987)1.85041429
122Abnormal gallbladder morphology (HP:0012437)1.84276059
123Abnormality of glycolysis (HP:0004366)1.84098194
124Increased serum pyruvate (HP:0003542)1.84098194
125Frequent falls (HP:0002359)1.82719616
126Spinal rigidity (HP:0003306)1.82459635
127Reduced subcutaneous adipose tissue (HP:0003758)1.82447948
128Back pain (HP:0003418)1.81760375
129Reduced antithrombin III activity (HP:0001976)1.81097650
130Spastic diplegia (HP:0001264)1.80689909
131Cholelithiasis (HP:0001081)1.79497647
132Abnormality of the musculature of the pelvis (HP:0001469)1.79232691
133Abnormality of the hip-girdle musculature (HP:0001445)1.79232691
134Increased nuchal translucency (HP:0010880)1.77754528
135Impaired pain sensation (HP:0007328)1.76452567
136Abnormality of pain sensation (HP:0010832)1.76452567
137Short nail (HP:0001799)1.74572884
138Increased intramyocellular lipid droplets (HP:0012240)1.68931089
139Hypoglycemic coma (HP:0001325)1.68046861
140Limb-girdle muscle weakness (HP:0003325)1.65264445
141Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62794200
142Abnormal cartilage morphology (HP:0002763)1.62782742
143Cerebral edema (HP:0002181)1.62548220
144Osteolytic defects of the hand bones (HP:0009699)1.60689195
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.60689195
146Tetraparesis (HP:0002273)1.60368253
147Selective tooth agenesis (HP:0001592)1.58324247
148Abnormality of the foot musculature (HP:0001436)1.58288703
149Abnormal mitochondria in muscle tissue (HP:0008316)1.57736673
150Postnatal microcephaly (HP:0005484)1.57627243
151Hypobetalipoproteinemia (HP:0003563)1.56913894
152Abnormality of methionine metabolism (HP:0010901)1.55406013
153Chromsome breakage (HP:0040012)1.55214101
154Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.54856429
155Insomnia (HP:0100785)1.54201112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.53574503
2PBK3.52762921
3TTN3.27873339
4TRIB33.16538906
5BUB13.07052596
6PHKG23.06383604
7PHKG13.06383604
8EIF2AK13.03094783
9PDK33.02294503
10PDK43.02294503
11NME22.79827079
12LMTK22.73086340
13TTK2.54279384
14OBSCN2.50149473
15EIF2AK32.44005498
16SRPK12.38453887
17MAP3K92.37308583
18KSR22.05348371
19CDC72.02083106
20VRK21.95748881
21IRAK31.92816981
22MINK11.87697770
23LATS21.87060498
24MST1R1.86098067
25PAK61.85511014
26BCKDK1.75105652
27MAP3K41.74107584
28EPHA41.65435073
29SCYL21.63960734
30NTRK31.63652720
31PINK11.61830400
32PDK21.59612012
33MAP2K41.53197589
34STK381.52962655
35PRKD31.50016519
36RIPK11.48847090
37SMG11.42224430
38EEF2K1.42160539
39KSR11.31852147
40PLK31.29823545
41CAMKK11.27898737
42MARK11.27607379
43ERBB41.27092228
44MET1.26112549
45DAPK21.26067571
46EPHA21.21536111
47ALK1.12574928
48TAOK11.11086056
49DMPK1.09359878
50MAP3K71.07532812
51MST41.04755364
52PAK31.03105536
53PDGFRA1.02522203
54MAPKAPK31.02447587
55NME11.01203393
56DAPK11.00187320
57PLK10.98789753
58AURKB0.97103288
59STK160.95824627
60RET0.92779023
61WNK30.92600581
62NTRK10.92141490
63FER0.90675384
64CDK70.87836956
65MYLK0.87670942
66MKNK10.87562171
67MUSK0.85831479
68MOS0.85198479
69CDK80.84966194
70NEK90.84417038
71LIMK10.83338267
72FLT30.81877911
73PTK20.80793056
74BRAF0.80409479
75BCR0.80192124
76TSSK60.78370154
77WNK40.76720443
78CHEK20.76283947
79MAP3K80.73816627
80PLK40.73456415
81STK38L0.73413912
82DAPK30.73159213
83TAF10.71827231
84CHEK10.71090487
85TRIM280.71031735
86PRKAA10.70598441
87EIF2AK20.70574795
88ERBB30.70467640
89ILK0.70249386
90CDK140.67439217
91MAP3K50.65794668
92AURKA0.65525490
93MAP2K10.65191399
94CDK150.64678250
95PIM20.63968056
96CDK180.63931536
97AKT20.61866530
98FGFR10.61521629
99BRSK10.61432463
100CDK60.61333192
101CDC42BPA0.60933641
102LATS10.60278303
103TAOK20.60105259
104PAK40.60049916
105ATR0.59656092
106CDK50.59585066
107TYRO30.59543335
108MAPKAPK50.57654887
109MAP3K110.57248210
110VRK10.55238739
111PAK20.54739603
112CDK11A0.54219820
113CAMK40.53585996
114ROCK10.53492754
115PRKCG0.52776743
116TESK10.52347269
117MAP3K20.52145188
118CAMK2G0.51606937
119NEK20.51545079
120RPS6KB20.51035594
121RAF10.50866337
122LRRK20.49454884
123MAP2K30.49379806
124MAPK120.49168401
125PTK60.48614524
126SGK30.48381866
127BRSK20.47153233
128MAP3K120.46522094
129ICK0.46450923
130BMX0.45100842
131CDK120.45100230
132PLK20.44598934
133NTRK20.44533137
134ARAF0.44513943
135CSNK2A20.44485662
136CLK10.43631586
137MTOR0.42684753
138STK40.41953071
139RPS6KA30.41326132
140PDK10.41296896
141MAP2K60.41029970
142DDR20.40068432
143MAP3K100.40009528
144CAMK2D0.39929800
145WEE10.39852054
146CSNK1G30.39630952
147PDPK10.38760595
148CAMK10.38672909
149STK240.38184648
150PIK3CA0.37546589
151CSNK1E0.36074424
152PRKD10.35893203
153CCNB10.34815192
154MAP2K70.34429916

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.10785220
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.59047791
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.67406207
4DNA replication_Homo sapiens_hsa030302.77222902
5Proteasome_Homo sapiens_hsa030502.69535725
6Carbon metabolism_Homo sapiens_hsa012002.53853896
7Cardiac muscle contraction_Homo sapiens_hsa042602.28837335
8Mismatch repair_Homo sapiens_hsa034302.20942657
9Biosynthesis of amino acids_Homo sapiens_hsa012302.20551785
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11478626
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99250185
12Propanoate metabolism_Homo sapiens_hsa006401.96661616
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.94659839
14One carbon pool by folate_Homo sapiens_hsa006701.93411235
15Nitrogen metabolism_Homo sapiens_hsa009101.92623457
16Synaptic vesicle cycle_Homo sapiens_hsa047211.92260217
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90620192
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89543303
19Pyruvate metabolism_Homo sapiens_hsa006201.89376664
20Dilated cardiomyopathy_Homo sapiens_hsa054141.85669159
21RNA transport_Homo sapiens_hsa030131.76807966
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70404588
23Fatty acid degradation_Homo sapiens_hsa000711.69943464
24Vitamin B6 metabolism_Homo sapiens_hsa007501.66004676
25Arginine biosynthesis_Homo sapiens_hsa002201.65708366
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63319945
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58376920
28Non-homologous end-joining_Homo sapiens_hsa034501.57596891
29Nucleotide excision repair_Homo sapiens_hsa034201.55008373
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52882937
31Spliceosome_Homo sapiens_hsa030401.51773318
32Base excision repair_Homo sapiens_hsa034101.50002307
33Butanoate metabolism_Homo sapiens_hsa006501.48980251
34Cell cycle_Homo sapiens_hsa041101.47215415
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45339863
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44363430
37Fatty acid metabolism_Homo sapiens_hsa012121.33562006
38Fatty acid elongation_Homo sapiens_hsa000621.33019030
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29896085
40Fructose and mannose metabolism_Homo sapiens_hsa000511.23399541
41Olfactory transduction_Homo sapiens_hsa047401.22872893
42Pyrimidine metabolism_Homo sapiens_hsa002401.18873461
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.16676995
44Glucagon signaling pathway_Homo sapiens_hsa049221.15583135
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14832067
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13031119
47Protein export_Homo sapiens_hsa030601.12780534
48GABAergic synapse_Homo sapiens_hsa047271.09397538
49Gastric acid secretion_Homo sapiens_hsa049711.07662447
50Circadian entrainment_Homo sapiens_hsa047131.06014167
51RNA polymerase_Homo sapiens_hsa030201.04054555
52Oxytocin signaling pathway_Homo sapiens_hsa049211.03630108
53Sulfur metabolism_Homo sapiens_hsa009201.03317245
54Long-term potentiation_Homo sapiens_hsa047201.03170458
55Insulin signaling pathway_Homo sapiens_hsa049101.02870503
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.02738688
57Parkinsons disease_Homo sapiens_hsa050120.99292776
58Steroid biosynthesis_Homo sapiens_hsa001000.98877562
59Insulin secretion_Homo sapiens_hsa049110.98328092
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.98285946
61Ribosome_Homo sapiens_hsa030100.97966849
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97008708
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96362736
64mTOR signaling pathway_Homo sapiens_hsa041500.95717528
65Glutathione metabolism_Homo sapiens_hsa004800.94885645
66mRNA surveillance pathway_Homo sapiens_hsa030150.90039795
67Bile secretion_Homo sapiens_hsa049760.88784248
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88190322
69Galactose metabolism_Homo sapiens_hsa000520.88059538
70Nicotine addiction_Homo sapiens_hsa050330.86008526
71Purine metabolism_Homo sapiens_hsa002300.84406087
72Dopaminergic synapse_Homo sapiens_hsa047280.84396962
73RNA degradation_Homo sapiens_hsa030180.83588059
74Folate biosynthesis_Homo sapiens_hsa007900.81796477
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79465891
76Oxidative phosphorylation_Homo sapiens_hsa001900.78268497
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76586525
78Salivary secretion_Homo sapiens_hsa049700.76534391
79Gap junction_Homo sapiens_hsa045400.76482571
80AMPK signaling pathway_Homo sapiens_hsa041520.75807770
81Amphetamine addiction_Homo sapiens_hsa050310.75348780
82Starch and sucrose metabolism_Homo sapiens_hsa005000.75153103
83Oocyte meiosis_Homo sapiens_hsa041140.74033301
84Pentose phosphate pathway_Homo sapiens_hsa000300.71439195
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70322934
86Insulin resistance_Homo sapiens_hsa049310.69442234
87HIF-1 signaling pathway_Homo sapiens_hsa040660.69116105
88Cholinergic synapse_Homo sapiens_hsa047250.69095165
89Thyroid cancer_Homo sapiens_hsa052160.68855995
90Type II diabetes mellitus_Homo sapiens_hsa049300.67561726
91* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67338752
92Sulfur relay system_Homo sapiens_hsa041220.67193083
93Alzheimers disease_Homo sapiens_hsa050100.66573347
94Homologous recombination_Homo sapiens_hsa034400.66223148
95Morphine addiction_Homo sapiens_hsa050320.66087136
96* Calcium signaling pathway_Homo sapiens_hsa040200.65609636
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65538653
98Collecting duct acid secretion_Homo sapiens_hsa049660.65299512
99Adherens junction_Homo sapiens_hsa045200.65043267
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64968377
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64851032
102Renin secretion_Homo sapiens_hsa049240.64660278
103N-Glycan biosynthesis_Homo sapiens_hsa005100.63040204
104GnRH signaling pathway_Homo sapiens_hsa049120.61447475
105Tight junction_Homo sapiens_hsa045300.61213058
106Glioma_Homo sapiens_hsa052140.59764557
107Tryptophan metabolism_Homo sapiens_hsa003800.59154252
108PPAR signaling pathway_Homo sapiens_hsa033200.57712310
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55938712
110Glutamatergic synapse_Homo sapiens_hsa047240.54538860
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53188043
112Selenocompound metabolism_Homo sapiens_hsa004500.52531302
113Metabolic pathways_Homo sapiens_hsa011000.52482791
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52134201
115Arginine and proline metabolism_Homo sapiens_hsa003300.51913630
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.51428408
117Phenylalanine metabolism_Homo sapiens_hsa003600.50653747
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50109057
119beta-Alanine metabolism_Homo sapiens_hsa004100.49801822
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48940203
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48827463
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48628050
123Basal transcription factors_Homo sapiens_hsa030220.47066615
124Estrogen signaling pathway_Homo sapiens_hsa049150.46864897
125Huntingtons disease_Homo sapiens_hsa050160.46002559
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45824606
127Endometrial cancer_Homo sapiens_hsa052130.44307815
128p53 signaling pathway_Homo sapiens_hsa041150.42510247
129Circadian rhythm_Homo sapiens_hsa047100.40516023
130cAMP signaling pathway_Homo sapiens_hsa040240.39671020
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38914203
132Tyrosine metabolism_Homo sapiens_hsa003500.38265805
133Fatty acid biosynthesis_Homo sapiens_hsa000610.37013361
134Fanconi anemia pathway_Homo sapiens_hsa034600.36544083
135Thyroid hormone synthesis_Homo sapiens_hsa049180.36519745
136Lysine degradation_Homo sapiens_hsa003100.35567162
137VEGF signaling pathway_Homo sapiens_hsa043700.35143224
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34937522
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.33171951
140Vibrio cholerae infection_Homo sapiens_hsa051100.32072211
141Melanogenesis_Homo sapiens_hsa049160.31215340
142Focal adhesion_Homo sapiens_hsa045100.29525963
143Hippo signaling pathway_Homo sapiens_hsa043900.28537791
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28482002
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28359338
146Small cell lung cancer_Homo sapiens_hsa052220.28128514
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.28114116
148Bladder cancer_Homo sapiens_hsa052190.27844014
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27706094
150Prion diseases_Homo sapiens_hsa050200.27066047
151Viral carcinogenesis_Homo sapiens_hsa052030.23931562
152Proteoglycans in cancer_Homo sapiens_hsa052050.20815909

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