ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	purine-containing compound salvage (GO:0043101)	4.95334871
2	regulation of immunoglobulin secretion (GO:0051023)	4.17932517
3	DNA double-strand break processing (GO:0000729)	4.15346335
4	IMP metabolic process (GO:0046040)	4.08314496
5	folic acid-containing compound biosynthetic process (GO:0009396)	3.90345856
6	DNA deamination (GO:0045006)	3.84450187
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.83757501
8	protein neddylation (GO:0045116)	3.82977405
9	xenobiotic catabolic process (GO:0042178)	3.76620835
10	signal peptide processing (GO:0006465)	3.75314223
11	IMP biosynthetic process (GO:0006188)	3.66695993
12	proteasome assembly (GO:0043248)	3.64140699
13	production of molecular mediator involved in inflammatory response (GO:0002532)	3.63319648
14	ATP synthesis coupled proton transport (GO:0015986)	3.54045595
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.54045595
16	activated T cell proliferation (GO:0050798)	3.50257472
17	regulation of chronic inflammatory response (GO:0002676)	3.48934130
18	urate metabolic process (GO:0046415)	3.46075040
19	regulation of cellular amino acid metabolic process (GO:0006521)	3.44999529
20	cullin deneddylation (GO:0010388)	3.35410869
21	DNA catabolic process, exonucleolytic (GO:0000738)	3.33138384
22	cytidine metabolic process (GO:0046087)	3.30926555
23	cytidine catabolic process (GO:0006216)	3.30926555
24	cytidine deamination (GO:0009972)	3.30926555
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26819872
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26819872
27	NADH dehydrogenase complex assembly (GO:0010257)	3.26819872
28	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.22832950
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.19266548
30	DNA ligation (GO:0006266)	3.18279158
31	AMP metabolic process (GO:0046033)	3.18252487
32	mismatch repair (GO:0006298)	3.18125968
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.14575828
34	protein heterotetramerization (GO:0051290)	3.13499725
35	viral mRNA export from host cell nucleus (GO:0046784)	3.13204151
36	GMP metabolic process (GO:0046037)	3.12592338
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.10291492
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.08723351
39	protein complex biogenesis (GO:0070271)	3.08343570
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.08049881
41	deoxyribonucleotide biosynthetic process (GO:0009263)	3.07365365
42	chaperone-mediated protein transport (GO:0072321)	3.05689665
43	inner mitochondrial membrane organization (GO:0007007)	3.05496089
44	tetrahydrofolate metabolic process (GO:0046653)	3.04391403
45	cytolysis (GO:0019835)	3.04154008
46	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.03362574
47	protein-cofactor linkage (GO:0018065)	3.03150268
48	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97882707
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96264016
50	respiratory electron transport chain (GO:0022904)	2.96064984
51	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.95191540
52	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.95191540
53	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.92940004
54	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.92940004
55	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.92940004
56	establishment of integrated proviral latency (GO:0075713)	2.92447867
57	retinal cone cell development (GO:0046549)	2.91649597
58	electron transport chain (GO:0022900)	2.91042428
59	valine metabolic process (GO:0006573)	2.90977604
60	positive regulation of defense response to virus by host (GO:0002230)	2.90609107
61	glyoxylate metabolic process (GO:0046487)	2.89894906
62	protein deneddylation (GO:0000338)	2.88266413
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.87258391
64	termination of RNA polymerase III transcription (GO:0006386)	2.87258391
65	methionine biosynthetic process (GO:0009086)	2.87244734
66	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.86435796
67	oxidative demethylation (GO:0070989)	2.84774942
68	acrosome assembly (GO:0001675)	2.84757207
69	aldehyde catabolic process (GO:0046185)	2.83259915
70	mitotic metaphase plate congression (GO:0007080)	2.82220181
71	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78032516
72	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.77915968
73	negative regulation of T-helper cell differentiation (GO:0045623)	2.77915968
74	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.77196798
75	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.77196798
76	cytokine biosynthetic process (GO:0042089)	2.76589082
77	amino acid salvage (GO:0043102)	2.76238492
78	L-methionine salvage (GO:0071267)	2.76238492
79	L-methionine biosynthetic process (GO:0071265)	2.76238492
80	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.76167977
81	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.72598167
82	alkaloid metabolic process (GO:0009820)	2.69198672
83	regulation of cellular amine metabolic process (GO:0033238)	2.69142701
84	negative regulation of ligase activity (GO:0051352)	2.68850544
85	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.68850544
86	lysine metabolic process (GO:0006553)	2.68526333
87	lysine catabolic process (GO:0006554)	2.68526333
88	DNA demethylation (GO:0080111)	2.66424358
89	methionine metabolic process (GO:0006555)	2.62983396
90	branched-chain amino acid catabolic process (GO:0009083)	2.62770606
91	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.60933451
92	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.60933451
93	negative regulation of thymocyte apoptotic process (GO:0070244)	2.59626446
94	water-soluble vitamin biosynthetic process (GO:0042364)	2.58764722
95	NAD biosynthetic process (GO:0009435)	2.58704483
96	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.58412905
97	deoxyribose phosphate biosynthetic process (GO:0046385)	2.58412905
98	behavioral response to nicotine (GO:0035095)	2.56283664
99	glycosphingolipid biosynthetic process (GO:0006688)	2.55867377
100	branched-chain amino acid metabolic process (GO:0009081)	2.52935165

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.35930981
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.85503190
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.72269956
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.42060832
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.23416121
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.88788134
7	VDR_22108803_ChIP-Seq_LS180_Human	2.78150038
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76660162
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.50907356
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.50019534
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38994911
12	E2F7_22180533_ChIP-Seq_HELA_Human	2.30164327
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.19813588
14	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.17444491
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13567109
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.13508891
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11028583
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.02070189
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.01740484
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.01348336
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00850048
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99845828
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.97909889
24	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.92966145
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90540144
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86913030
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86523463
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.84941767
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.79835153
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77558930
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.68228917
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.67890649
33	EWS_26573619_Chip-Seq_HEK293_Human	1.67386460
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.66559473
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.60327837
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.57258062
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.57054076
38	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55018453
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.54496216
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50581188
41	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.49990189
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.47743241
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.46944877
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.46827472
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.43418686
46	GBX2_23144817_ChIP-Seq_PC3_Human	1.42062621
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.40702369
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.34975288
49	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.34644223
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34302828
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33463569
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.31786045
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31786045
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29544196
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27001622
56	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.26921507
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.26520007
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22644855
59	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.20875113
60	FUS_26573619_Chip-Seq_HEK293_Human	1.20772871
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20354599
62	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.19428640
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16997089
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16649010
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16334567
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.16018803
67	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15543024
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.13416656
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.13316418
70	GATA3_26560356_Chip-Seq_TH2_Human	1.10999182
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10785742
72	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.10288574
73	P300_19829295_ChIP-Seq_ESCs_Human	1.09643417
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05266530
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99973002
76	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.98141283
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.97284770
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96723452
79	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.96431850
80	NCOR_22424771_ChIP-Seq_293T_Human	0.94168256
81	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93584439
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93508223
83	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.93432562
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91646969
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90293261
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.88469476
87	XRN2_22483619_ChIP-Seq_HELA_Human	0.87287911
88	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.86920464
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86621897
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86621897
91	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.86583367
92	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85858991
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.84705309
94	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.84108252
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.84093072
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.83626876
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83349144
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.82894190
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.82797583
100	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.82350575

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.27609420
2	MP0003011_delayed_dark_adaptation	3.69790618
3	MP0008875_abnormal_xenobiotic_pharmacok	3.14896876
4	MP0002736_abnormal_nociception_after	3.06611453
5	MP0002876_abnormal_thyroid_physiology	2.69924455
6	MP0008058_abnormal_DNA_repair	2.64928917
7	MP0001348_abnormal_lacrimal_gland	2.45053577
8	MP0003195_calcinosis	2.43570978
9	MP0002102_abnormal_ear_morphology	2.37715631
10	MP0002138_abnormal_hepatobiliary_system	2.34953383
11	MP0001968_abnormal_touch/_nociception	2.33073638
12	MP0003806_abnormal_nucleotide_metabolis	2.14948168
13	MP0001984_abnormal_olfaction	2.13875489
14	MP0003880_abnormal_central_pattern	2.09221437
15	MP0005253_abnormal_eye_physiology	2.04229407
16	MP0002638_abnormal_pupillary_reflex	2.03441597
17	MP0002254_reproductive_system_inflammat	1.98061896
18	MP0001790_abnormal_immune_system	1.97028023
19	MP0005387_immune_system_phenotype	1.97028023
20	MP0005551_abnormal_eye_electrophysiolog	1.94670842
21	MP0009785_altered_susceptibility_to	1.89450201
22	MP0010094_abnormal_chromosome_stability	1.87349701
23	MP0008877_abnormal_DNA_methylation	1.76723464
24	MP0004145_abnormal_muscle_electrophysio	1.75884771
25	MP0008872_abnormal_physiological_respon	1.73781410
26	MP0005377_hearing/vestibular/ear_phenot	1.73677460
27	MP0003878_abnormal_ear_physiology	1.73677460
28	MP0009697_abnormal_copulation	1.72225534
29	MP0005310_abnormal_salivary_gland	1.68312708
30	MP0001529_abnormal_vocalization	1.67512117
31	MP0002090_abnormal_vision	1.65853407
32	MP0002166_altered_tumor_susceptibility	1.58746531
33	MP0000685_abnormal_immune_system	1.57238561
34	MP0001502_abnormal_circadian_rhythm	1.56555790
35	MP0001873_stomach_inflammation	1.56488153
36	MP0006072_abnormal_retinal_apoptosis	1.55749183
37	MP0001661_extended_life_span	1.52909292
38	MP0002006_tumorigenesis	1.51959227
39	MP0002837_dystrophic_cardiac_calcinosis	1.49917136
40	MP0004147_increased_porphyrin_level	1.48931198
41	MP0001835_abnormal_antigen_presentation	1.40634973
42	MP0003763_abnormal_thymus_physiology	1.36767024
43	MP0000747_muscle_weakness	1.36266623
44	MP0001764_abnormal_homeostasis	1.35107097
45	MP0006276_abnormal_autonomic_nervous	1.34610144
46	MP0005084_abnormal_gallbladder_morpholo	1.30468134
47	MP0000372_irregular_coat_pigmentation	1.24390365
48	MP0006035_abnormal_mitochondrial_morpho	1.23995383
49	MP0003950_abnormal_plasma_membrane	1.21847873
50	MP0003866_abnormal_defecation	1.19770135
51	MP0003693_abnormal_embryo_hatching	1.19120836
52	MP0004084_abnormal_cardiac_muscle	1.13922583
53	MP0006082_CNS_inflammation	1.11018983
54	MP0008789_abnormal_olfactory_epithelium	1.08549091
55	MP0001485_abnormal_pinna_reflex	1.06859756
56	MP0001919_abnormal_reproductive_system	1.05700465
57	MP0001486_abnormal_startle_reflex	1.05217730
58	MP0003045_fibrosis	1.05023535
59	MP0005332_abnormal_amino_acid	1.04924097
60	MP0001501_abnormal_sleep_pattern	1.03058904
61	MP0005646_abnormal_pituitary_gland	1.01191884
62	MP0002148_abnormal_hypersensitivity_rea	0.99362619
63	MP0005319_abnormal_enzyme/_coenzyme	0.99308353
64	MP0006036_abnormal_mitochondrial_physio	0.97419320
65	MP0002272_abnormal_nervous_system	0.95816250
66	MP0004957_abnormal_blastocyst_morpholog	0.93893940
67	MP0005645_abnormal_hypothalamus_physiol	0.93342592
68	MP0003436_decreased_susceptibility_to	0.91747087
69	MP0005000_abnormal_immune_tolerance	0.90316131
70	MP0002067_abnormal_sensory_capabilities	0.89880813
71	MP0005187_abnormal_penis_morphology	0.88623366
72	MP0005266_abnormal_metabolism	0.88230877
73	MP0004885_abnormal_endolymph	0.86832316
74	MP0003786_premature_aging	0.86672370
75	MP0001800_abnormal_humoral_immune	0.85705052
76	MP0000427_abnormal_hair_cycle	0.85488228
77	MP0002095_abnormal_skin_pigmentation	0.84999129
78	MP0002277_abnormal_respiratory_mucosa	0.84630846
79	MP0005499_abnormal_olfactory_system	0.82693992
80	MP0005394_taste/olfaction_phenotype	0.82693992
81	MP0001849_ear_inflammation	0.82261265
82	MP0000647_abnormal_sebaceous_gland	0.82223069
83	MP0005389_reproductive_system_phenotype	0.79899009
84	MP0003567_abnormal_fetal_cardiomyocyte	0.79702520
85	MP0010155_abnormal_intestine_physiology	0.78023085
86	MP0002139_abnormal_hepatobiliary_system	0.77984526
87	MP0001905_abnormal_dopamine_level	0.75257034
88	MP0001986_abnormal_taste_sensitivity	0.72923320
89	MP0002229_neurodegeneration	0.72640518
90	MP0003252_abnormal_bile_duct	0.71647033
91	MP0005584_abnormal_enzyme/coenzyme_acti	0.71231628
92	MP0009745_abnormal_behavioral_response	0.70983637
93	MP0004036_abnormal_muscle_relaxation	0.70945589
94	MP0005636_abnormal_mineral_homeostasis	0.70180146
95	MP0000358_abnormal_cell_content/	0.70168647
96	MP0003646_muscle_fatigue	0.69702143
97	MP0004215_abnormal_myocardial_fiber	0.67887361
98	MP0005085_abnormal_gallbladder_physiolo	0.67141647
99	MP0003718_maternal_effect	0.66532623
100	MP0001727_abnormal_embryo_implantation	0.66429460

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Visual hallucinations (HP:0002367)	4.61355799
2	Acute necrotizing encephalopathy (HP:0006965)	4.45277873
3	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.22544445
4	Acute encephalopathy (HP:0006846)	4.15856910
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.01257326
6	Progressive macrocephaly (HP:0004481)	3.79111390
7	Mitochondrial inheritance (HP:0001427)	3.73318542
8	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.63040945
9	Autoimmune hemolytic anemia (HP:0001890)	3.58628779
10	Increased CSF lactate (HP:0002490)	3.58163421
11	Increased cerebral lipofuscin (HP:0011813)	3.44622949
12	Autoimmune thrombocytopenia (HP:0001973)	3.28492812
13	3-Methylglutaconic aciduria (HP:0003535)	3.23473265
14	Congenital stationary night blindness (HP:0007642)	3.07640544
15	Cerebral edema (HP:0002181)	3.05162682
16	Spastic diplegia (HP:0001264)	3.04421035
17	Testicular atrophy (HP:0000029)	2.82593597
18	Dyschromatopsia (HP:0007641)	2.82377885
19	Abnormality of purine metabolism (HP:0004352)	2.79085775
20	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.74153770
21	Increased hepatocellular lipid droplets (HP:0006565)	2.64458284
22	Hepatocellular necrosis (HP:0001404)	2.58877876
23	Hypoproteinemia (HP:0003075)	2.58117957
24	Lactic acidosis (HP:0003128)	2.57764063
25	IgG deficiency (HP:0004315)	2.56876227
26	Congenital, generalized hypertrichosis (HP:0004540)	2.53971194
27	Methylmalonic acidemia (HP:0002912)	2.52147028
28	Optic disc pallor (HP:0000543)	2.50795342
29	Lipid accumulation in hepatocytes (HP:0006561)	2.50608243
30	Cerebral hypomyelination (HP:0006808)	2.47092951
31	Increased serum lactate (HP:0002151)	2.47026288
32	Hepatic necrosis (HP:0002605)	2.43460873
33	Exercise intolerance (HP:0003546)	2.43232424
34	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.42393486
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.42393486
36	Tetraparesis (HP:0002273)	2.42310273
37	Respiratory failure (HP:0002878)	2.40707713
38	Aplastic anemia (HP:0001915)	2.38817975
39	Abnormality of T cell physiology (HP:0011840)	2.36570565
40	Cerebral palsy (HP:0100021)	2.33555317
41	Shoulder girdle muscle weakness (HP:0003547)	2.33002261
42	Lethargy (HP:0001254)	2.31353651
43	Central scotoma (HP:0000603)	2.31094472
44	Abnormality of T cells (HP:0002843)	2.30525781
45	Renal cortical cysts (HP:0000803)	2.28703927
46	Parakeratosis (HP:0001036)	2.27472625
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.24955682
48	Increased intramyocellular lipid droplets (HP:0012240)	2.23412310
49	Prostate neoplasm (HP:0100787)	2.23283862
50	Medial flaring of the eyebrow (HP:0010747)	2.22944197
51	Hypoplasia of the fovea (HP:0007750)	2.17873690
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.17873690
53	Hemiplegia (HP:0002301)	2.17648257
54	Absent phalangeal crease (HP:0006109)	2.14945875
55	Long clavicles (HP:0000890)	2.12614613
56	Gout (HP:0001997)	2.11921423
57	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.11783783
58	Leukodystrophy (HP:0002415)	2.11204046
59	Hyperglycinemia (HP:0002154)	2.08793777
60	Palpitations (HP:0001962)	2.06578873
61	Opisthotonus (HP:0002179)	2.05601407
62	Abnormal albumin level (HP:0012116)	2.05024644
63	Hypoalbuminemia (HP:0003073)	2.05024644
64	Oral leukoplakia (HP:0002745)	2.01859746
65	Absent speech (HP:0001344)	1.99537658
66	Cholecystitis (HP:0001082)	1.99399683
67	Abnormal gallbladder physiology (HP:0012438)	1.99399683
68	Conjunctival hamartoma (HP:0100780)	1.98302820
69	Abnormal biliary tract physiology (HP:0012439)	1.95786108
70	Bile duct proliferation (HP:0001408)	1.95786108
71	Abnormality of methionine metabolism (HP:0010901)	1.94564730
72	Brittle hair (HP:0002299)	1.94025014
73	Abnormality of nucleobase metabolism (HP:0010932)	1.93794320
74	Increased serum pyruvate (HP:0003542)	1.92578402
75	Hypomagnesemia (HP:0002917)	1.90842304
76	Abnormal finger flexion creases (HP:0006143)	1.89508916
77	Malignant hyperthermia (HP:0002047)	1.88683814
78	Myoglobinuria (HP:0002913)	1.88662970
79	Abnormality of fatty-acid metabolism (HP:0004359)	1.88640951
80	Rimmed vacuoles (HP:0003805)	1.88184804
81	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.86736898
82	Abnormality of alanine metabolism (HP:0010916)	1.86736898
83	Hyperalaninemia (HP:0003348)	1.86736898
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86240358
85	Abnormality of the fovea (HP:0000493)	1.85166253
86	Pancreatic cysts (HP:0001737)	1.84269685
87	Methylmalonic aciduria (HP:0012120)	1.82976292
88	Congenital primary aphakia (HP:0007707)	1.82689449
89	Thyroid-stimulating hormone excess (HP:0002925)	1.82675428
90	Gait imbalance (HP:0002141)	1.82094506
91	Increased muscle lipid content (HP:0009058)	1.81889225
92	Amyotrophic lateral sclerosis (HP:0007354)	1.81520002
93	Severe combined immunodeficiency (HP:0004430)	1.80745976
94	Hypobetalipoproteinemia (HP:0003563)	1.79366099
95	Tetany (HP:0001281)	1.78899984
96	Pelvic girdle muscle weakness (HP:0003749)	1.78598364
97	Abnormality of the renal cortex (HP:0011035)	1.77565763
98	Pheochromocytoma (HP:0002666)	1.77267911
99	Supernumerary spleens (HP:0009799)	1.76993749
100	Abnormality of glycolysis (HP:0004366)	1.72811432

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	8.45877808
2	TXK	3.33417271
3	TSSK6	2.87527263
4	TIE1	2.73694905
5	TRIM28	2.65723772
6	NME1	2.64703531
7	BCR	2.34953394
8	VRK2	2.33999425
9	KDR	2.17150788
10	CCNB1	2.12209501
11	MAP4K1	1.83278592
12	FRK	1.77384873
13	MAP3K12	1.62179849
14	PBK	1.58843182
15	GRK1	1.57020030
16	MST4	1.52957498
17	ADRBK2	1.47378247
18	TAF1	1.45343514
19	CSNK1G3	1.40844318
20	PHKG2	1.39303012
21	PHKG1	1.39303012
22	WEE1	1.36100654
23	VRK1	1.31934704
24	CSNK1A1L	1.31310719
25	CDC7	1.31211889
26	STK38L	1.30201492
27	EIF2AK1	1.26557220
28	EIF2AK3	1.20034920
29	PLK3	1.16906571
30	SRPK1	1.15839223
31	TESK2	1.12124006
32	NUAK1	1.08818051
33	MUSK	1.06297980
34	CSNK1G2	1.05227344
35	OBSCN	1.04584044
36	GRK7	1.01476391
37	CSNK1G1	1.00693630
38	TLK1	0.96777411
39	MYLK	0.94361023
40	MKNK1	0.92471064
41	STK16	0.91493272
42	FLT3	0.91460250
43	BUB1	0.89360089
44	MAP4K2	0.84766888
45	STK39	0.81408323
46	PDK2	0.80044365
47	MAPK13	0.79439296
48	PIK3CG	0.73912489
49	BRSK1	0.68148564
50	BRSK2	0.67901988
51	ZAK	0.67049878
52	PLK4	0.66285233
53	OXSR1	0.65337301
54	WNK3	0.65073932
55	MAP2K6	0.64698222
56	BCKDK	0.64131560
57	CSNK2A1	0.61569823
58	EIF2AK2	0.60881800
59	GRK5	0.53928146
60	MKNK2	0.53501892
61	PNCK	0.52797963
62	INSRR	0.52404213
63	IGF1R	0.52092869
64	TNK2	0.51988624
65	CAMK2A	0.51970514
66	ALK	0.48666860
67	SYK	0.48296540
68	CSNK2A2	0.48247431
69	FGR	0.48087552
70	LYN	0.47706691
71	BMPR2	0.46164852
72	MARK1	0.45662645
73	PKN1	0.44450122
74	PLK1	0.44251546
75	AURKA	0.42708000
76	TAOK3	0.42598494
77	PLK2	0.41865429
78	MAP3K11	0.40487376
79	CAMK2D	0.40197635
80	CAMKK2	0.40120000
81	TEC	0.38645429
82	CSNK1A1	0.37902704
83	RPS6KB1	0.37061876
84	CDK14	0.37061822
85	PRKCG	0.36588390
86	TTK	0.36328134
87	MAPKAPK5	0.35489262
88	WNK4	0.35029697
89	PAK3	0.34134004
90	ADRBK1	0.33934842
91	PRKACA	0.33676043
92	CAMK2G	0.33017664
93	ATR	0.32636153
94	LIMK1	0.31201049
95	AURKB	0.30035586
96	FES	0.29743995
97	CSF1R	0.29217547
98	CDK18	0.27688368
99	DYRK2	0.26069527
100	CSK	0.25035398

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.98266132
2	Protein export_Homo sapiens_hsa03060	2.84120068
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.75553459
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.72965227
5	Parkinsons disease_Homo sapiens_hsa05012	2.63288413
6	One carbon pool by folate_Homo sapiens_hsa00670	2.60022654
7	Sulfur metabolism_Homo sapiens_hsa00920	2.56020644
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.38339234
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.36277718
10	Mismatch repair_Homo sapiens_hsa03430	2.27604403
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.14432969
12	Caffeine metabolism_Homo sapiens_hsa00232	2.12989514
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.07069824
14	RNA polymerase_Homo sapiens_hsa03020	2.01581052
15	Propanoate metabolism_Homo sapiens_hsa00640	1.99419910
16	Homologous recombination_Homo sapiens_hsa03440	1.94815087
17	DNA replication_Homo sapiens_hsa03030	1.72500018
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69243747
19	Huntingtons disease_Homo sapiens_hsa05016	1.67898363
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.52431421
21	Alzheimers disease_Homo sapiens_hsa05010	1.52230511
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.51067357
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.45584200
24	Spliceosome_Homo sapiens_hsa03040	1.39632665
25	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.36727265
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33502866
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33131819
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31153634
29	Phototransduction_Homo sapiens_hsa04744	1.31118040
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30538126
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26421624
32	RNA degradation_Homo sapiens_hsa03018	1.25474544
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24831107
34	Purine metabolism_Homo sapiens_hsa00230	1.21689970
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21144259
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20781300
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.19673251
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.16768500
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16483529
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.12494829
41	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.12315967
42	Butanoate metabolism_Homo sapiens_hsa00650	1.11268858
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10781879
44	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.07994261
45	Peroxisome_Homo sapiens_hsa04146	1.07881773
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.03160185
47	Asthma_Homo sapiens_hsa05310	1.01817170
48	Carbon metabolism_Homo sapiens_hsa01200	1.00868655
49	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00208009
50	Tryptophan metabolism_Homo sapiens_hsa00380	1.00193302
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.97695403
52	RNA transport_Homo sapiens_hsa03013	0.94450260
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94122289
54	Basal transcription factors_Homo sapiens_hsa03022	0.92819696
55	Retinol metabolism_Homo sapiens_hsa00830	0.91639514
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86565780
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86077367
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.85455168
59	Allograft rejection_Homo sapiens_hsa05330	0.84100582
60	Glutathione metabolism_Homo sapiens_hsa00480	0.80232060
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.78568176
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.78298723
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.76708543
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75210511
65	Metabolic pathways_Homo sapiens_hsa01100	0.75065733
66	Base excision repair_Homo sapiens_hsa03410	0.74625554
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.71896816
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.67233975
69	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.66754688
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63927665
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62620767
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62061572
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.60768152
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.60028407
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59158996
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58527532
77	Fatty acid degradation_Homo sapiens_hsa00071	0.57546274
78	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.57095342
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56538027
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54971672
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.54400032
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53334069
83	GABAergic synapse_Homo sapiens_hsa04727	0.51932777
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.50845111
85	Olfactory transduction_Homo sapiens_hsa04740	0.49772572
86	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42241631
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.41802580
88	Fatty acid elongation_Homo sapiens_hsa00062	0.41437526
89	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.41394941
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.40774262
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.39585243
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38777163
93	Sulfur relay system_Homo sapiens_hsa04122	0.38708369
94	Ribosome_Homo sapiens_hsa03010	0.38053767
95	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36609923
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.35642317
97	Folate biosynthesis_Homo sapiens_hsa00790	0.34287410
98	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.32658055
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.30784819
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29886247

VDAC1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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