ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	purine-containing compound salvage (GO:0043101)	5.74575729
2	production of molecular mediator involved in inflammatory response (GO:0002532)	5.66469945
3	negative regulation of thymocyte apoptotic process (GO:0070244)	5.31605217
4	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.28128198
5	purine nucleotide salvage (GO:0032261)	4.89640933
6	DNA deamination (GO:0045006)	4.69505024
7	proteasome assembly (GO:0043248)	4.50178648
8	IMP biosynthetic process (GO:0006188)	4.46810316
9	mature B cell differentiation involved in immune response (GO:0002313)	4.45691586
10	rRNA modification (GO:0000154)	4.19059179
11	urate metabolic process (GO:0046415)	4.13675232
12	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	4.11035108
13	GMP metabolic process (GO:0046037)	4.06248523
14	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.98348987
15	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.95697167
16	negative regulation of heart rate (GO:0010459)	3.93955291
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.92266275
18	nucleotide-sugar biosynthetic process (GO:0009226)	3.89673522
19	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.79278249
20	ATP synthesis coupled proton transport (GO:0015986)	3.78515013
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.78515013
22	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.68519845
23	mismatch repair (GO:0006298)	3.65415678
24	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.64893339
25	regulation of cellular amino acid metabolic process (GO:0006521)	3.63960776
26	regulation of interleukin-6 biosynthetic process (GO:0045408)	3.60903376
27	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.60256864
28	ribosomal large subunit biogenesis (GO:0042273)	3.55685577
29	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.55168552
30	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.55168552
31	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	3.54888447
32	response to interferon-beta (GO:0035456)	3.54862431
33	activated T cell proliferation (GO:0050798)	3.53604309
34	IMP metabolic process (GO:0046040)	3.53359136
35	negative regulation of ligase activity (GO:0051352)	3.52340891
36	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.52340891
37	viral mRNA export from host cell nucleus (GO:0046784)	3.50882842
38	pseudouridine synthesis (GO:0001522)	3.40625161
39	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.40043911
40	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.39582596
41	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.24333390
42	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.24333390
43	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.24333390
44	telomere maintenance via semi-conservative replication (GO:0032201)	3.24255694
45	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.23829698
46	rRNA methylation (GO:0031167)	3.23734715
47	purine nucleobase biosynthetic process (GO:0009113)	3.21205060
48	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.18006822
49	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.18006822
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.16194146
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.15277497
52	purine nucleobase metabolic process (GO:0006144)	3.10904359
53	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	3.10628498
54	signal peptide processing (GO:0006465)	3.10580196
55	lipoxygenase pathway (GO:0019372)	3.09912627
56	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.08508818
57	inner mitochondrial membrane organization (GO:0007007)	3.08457206
58	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.08258132
59	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.08258132
60	cytokine secretion (GO:0050663)	3.06857914
61	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.06218023
62	ribosome assembly (GO:0042255)	3.05868178
63	positive regulation of defense response to virus by host (GO:0002230)	3.04846511
64	positive regulation of heart rate (GO:0010460)	3.04763043
65	regulation of thymocyte apoptotic process (GO:0070243)	3.03916971
66	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.00863509
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99355332
68	replicative senescence (GO:0090399)	2.98576196
69	grooming behavior (GO:0007625)	2.97734271
70	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.95602536
71	behavioral response to nicotine (GO:0035095)	2.94308106
72	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.89973791
73	NAD biosynthetic process (GO:0009435)	2.89884266
74	protein neddylation (GO:0045116)	2.89762071
75	cellular response to exogenous dsRNA (GO:0071360)	2.89327025
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88592660
77	NADH dehydrogenase complex assembly (GO:0010257)	2.88592660
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88592660
79	positive regulation of ligase activity (GO:0051351)	2.87861800
80	DNA strand elongation involved in DNA replication (GO:0006271)	2.87179274
81	mitochondrial fusion (GO:0008053)	2.86772326
82	telomere maintenance via recombination (GO:0000722)	2.85782970
83	mature B cell differentiation (GO:0002335)	2.85752152
84	regulation of interleukin-8 biosynthetic process (GO:0045414)	2.85717546
85	DNA catabolic process, exonucleolytic (GO:0000738)	2.85566083
86	positive regulation of osteoclast differentiation (GO:0045672)	2.83097209
87	regulation of cellular amine metabolic process (GO:0033238)	2.81080003
88	GDP-mannose metabolic process (GO:0019673)	2.80879791
89	mitotic metaphase plate congression (GO:0007080)	2.76999838
90	respiratory electron transport chain (GO:0022904)	2.72302277
91	DNA strand elongation (GO:0022616)	2.71586950
92	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.71317211
93	rRNA processing (GO:0006364)	2.68381398
94	electron transport chain (GO:0022900)	2.68183118
95	DNA double-strand break processing (GO:0000729)	2.66499346
96	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	2.63961427
97	nucleotide-sugar metabolic process (GO:0009225)	2.63075506
98	regulation of chronic inflammatory response (GO:0002676)	2.62845634
99	aspartate family amino acid catabolic process (GO:0009068)	2.62558500
100	cellular metabolic compound salvage (GO:0043094)	2.62315844

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.71415207
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.86352326
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.51838809
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.44248419
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.80151063
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.43467774
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.35016409
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.23042645
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.94129048
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.86578118
11	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.81355941
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.69296439
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.62529557
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.51252116
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.51246477
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50205349
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.49762029
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49357690
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.38546382
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.32683770
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.30230396
22	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28005688
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.14946594
24	VDR_22108803_ChIP-Seq_LS180_Human	2.07489075
25	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.02920231
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.99374502
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98429374
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.96188817
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.93615392
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.90275616
31	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.87884465
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.87596595
33	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.83991363
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.80094909
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79091457
36	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.78537188
37	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.77949659
38	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.65524770
39	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.60158805
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58199220
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.57777233
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.55233804
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.49048581
44	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.47295617
45	ZNF274_21170338_ChIP-Seq_K562_Hela	1.45706114
46	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43327800
47	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.40779276
48	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.40339626
49	XRN2_22483619_ChIP-Seq_HELA_Human	1.38458024
50	MYB_26560356_Chip-Seq_TH2_Human	1.34766847
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30726930
52	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.28771506
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28113364
54	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.27949371
55	SPI1_23547873_ChIP-Seq_NB4_Human	1.26312319
56	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25070278
57	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.23898283
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.21769968
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.20146295
60	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.18631701
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15966360
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15869927
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14458105
64	GATA1_22025678_ChIP-Seq_K562_Human	1.09130910
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.07347554
66	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.04852414
67	EWS_26573619_Chip-Seq_HEK293_Human	1.04348707
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04149518
69	GATA3_26560356_Chip-Seq_TH2_Human	1.03239365
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.01962466
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98685461
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.98488019
73	TP53_22573176_ChIP-Seq_HFKS_Human	0.98270221
74	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.97241023
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95542972
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94918254
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.94760900
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91678786
79	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89761376
80	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89621421
81	AR_21909140_ChIP-Seq_LNCAP_Human	0.89476643
82	KDM5A_27292631_Chip-Seq_BREAST_Human	0.88522155
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.87888243
84	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.87474180
85	ELF5_23300383_ChIP-Seq_T47D_Human	0.85476365
86	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.84857501
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.84778372
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84107480
89	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.79773436
90	ER_23166858_ChIP-Seq_MCF-7_Human	0.79557305
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.79132656
92	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.78979211
93	MYB_26560356_Chip-Seq_TH1_Human	0.78554105
94	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.78131304
95	AR_20517297_ChIP-Seq_VCAP_Human	0.77618275
96	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.76919465
97	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.75639039
98	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.73439468
99	CIITA_25753668_ChIP-Seq_RAJI_Human	0.73048993
100	IGF1R_20145208_ChIP-Seq_DFB_Human	0.72886563

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003436_decreased_susceptibility_to	4.05002293
2	MP0008057_abnormal_DNA_replication	3.70404512
3	MP0005671_abnormal_response_to	3.61766329
4	MP0003950_abnormal_plasma_membrane	3.46814038
5	MP0002254_reproductive_system_inflammat	3.20213097
6	MP0008058_abnormal_DNA_repair	3.07202062
7	MP0009697_abnormal_copulation	3.03067264
8	MP0002090_abnormal_vision	3.01005917
9	MP0010094_abnormal_chromosome_stability	2.96613101
10	MP0003693_abnormal_embryo_hatching	2.92139466
11	MP0001835_abnormal_antigen_presentation	2.88807224
12	MP0009785_altered_susceptibility_to	2.81254434
13	MP0001790_abnormal_immune_system	2.57383716
14	MP0005387_immune_system_phenotype	2.57383716
15	MP0003111_abnormal_nucleus_morphology	2.41874609
16	MP0002148_abnormal_hypersensitivity_rea	2.27688241
17	MP0003763_abnormal_thymus_physiology	2.11262164
18	MP0000372_irregular_coat_pigmentation	2.02564362
19	MP0009764_decreased_sensitivity_to	1.98403527
20	MP0010155_abnormal_intestine_physiology	1.92198836
21	MP0004957_abnormal_blastocyst_morpholog	1.85998093
22	MP0002933_joint_inflammation	1.85712248
23	MP0002006_tumorigenesis	1.84577244
24	MP0003195_calcinosis	1.77356229
25	MP0008007_abnormal_cellular_replicative	1.76151160
26	MP0005646_abnormal_pituitary_gland	1.75300051
27	MP0001853_heart_inflammation	1.72934333
28	MP0005000_abnormal_immune_tolerance	1.72721387
29	MP0001533_abnormal_skeleton_physiology	1.71555900
30	MP0006036_abnormal_mitochondrial_physio	1.69026898
31	MP0008875_abnormal_xenobiotic_pharmacok	1.66649555
32	MP0001873_stomach_inflammation	1.64846202
33	MP0003077_abnormal_cell_cycle	1.57792363
34	MP0000685_abnormal_immune_system	1.57713514
35	MP0003866_abnormal_defecation	1.56502201
36	MP0002405_respiratory_system_inflammati	1.56167360
37	MP0006035_abnormal_mitochondrial_morpho	1.54082870
38	MP0001800_abnormal_humoral_immune	1.53251755
39	MP0004147_increased_porphyrin_level	1.51137169
40	MP0002452_abnormal_antigen_presenting	1.50083688
41	MP0001849_ear_inflammation	1.45900852
42	MP0001819_abnormal_immune_cell	1.40902101
43	MP0008775_abnormal_heart_ventricle	1.40789892
44	MP0002723_abnormal_immune_serum	1.39234879
45	MP0003786_premature_aging	1.38477804
46	MP0002420_abnormal_adaptive_immunity	1.37395919
47	MP0005165_increased_susceptibility_to	1.35454917
48	MP0000490_abnormal_crypts_of	1.33771713
49	MP0002876_abnormal_thyroid_physiology	1.29685169
50	MP0001502_abnormal_circadian_rhythm	1.29309524
51	MP0002166_altered_tumor_susceptibility	1.29139765
52	MP0005025_abnormal_response_to	1.27706344
53	MP0003806_abnormal_nucleotide_metabolis	1.22329374
54	MP0000516_abnormal_urinary_system	1.14965116
55	MP0005367_renal/urinary_system_phenotyp	1.14965116
56	MP0002736_abnormal_nociception_after	1.11987562
57	MP0002419_abnormal_innate_immunity	1.11675725
58	MP0008877_abnormal_DNA_methylation	1.11344678
59	MP0005332_abnormal_amino_acid	1.03688158
60	MP0002277_abnormal_respiratory_mucosa	1.03548531
61	MP0002722_abnormal_immune_system	1.02106732
62	MP0005647_abnormal_sex_gland	1.01438166
63	MP0001845_abnormal_inflammatory_respons	1.00846186
64	MP0008872_abnormal_physiological_respon	1.00521258
65	MP0001542_abnormal_bone_strength	0.96802635
66	MP0003718_maternal_effect	0.93349657
67	MP0000015_abnormal_ear_pigmentation	0.93065902
68	MP0008469_abnormal_protein_level	0.92276318
69	MP0003186_abnormal_redox_activity	0.90569325
70	MP0004084_abnormal_cardiac_muscle	0.88115974
71	MP0001348_abnormal_lacrimal_gland	0.86614458
72	MP0004215_abnormal_myocardial_fiber	0.85860714
73	MP0005464_abnormal_platelet_physiology	0.85092907
74	MP0002429_abnormal_blood_cell	0.84663098
75	MP0004134_abnormal_chest_morphology	0.83716430
76	MP0002398_abnormal_bone_marrow	0.83233401
77	MP0000716_abnormal_immune_system	0.82916722
78	MP0000689_abnormal_spleen_morphology	0.78941732
79	MP0005319_abnormal_enzyme/_coenzyme	0.78202359
80	MP0003724_increased_susceptibility_to	0.76875206
81	MP0008873_increased_physiological_sensi	0.73180855
82	MP0002019_abnormal_tumor_incidence	0.73178092
83	MP0005187_abnormal_penis_morphology	0.73012568
84	MP0001881_abnormal_mammary_gland	0.72650307
85	MP0009333_abnormal_splenocyte_physiolog	0.71811489
86	MP0001243_abnormal_dermal_layer	0.69024120
87	MP0000703_abnormal_thymus_morphology	0.67937118
88	MP0005390_skeleton_phenotype	0.67277913
89	MP0002136_abnormal_kidney_physiology	0.65930119
90	MP0002332_abnormal_exercise_endurance	0.65504014
91	MP0004145_abnormal_muscle_electrophysio	0.64516087
92	MP0003448_altered_tumor_morphology	0.63927830
93	MP0002095_abnormal_skin_pigmentation	0.63884395
94	MP0000627_abnormal_mammary_gland	0.63604411
95	MP0001764_abnormal_homeostasis	0.61999106
96	MP0005266_abnormal_metabolism	0.60875149
97	MP0005670_abnormal_white_adipose	0.60860955
98	MP0005084_abnormal_gallbladder_morpholo	0.60392454
99	MP0005584_abnormal_enzyme/coenzyme_acti	0.59825535
100	MP0006082_CNS_inflammation	0.57555461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Autoimmune thrombocytopenia (HP:0001973)	6.95780258
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	6.65774394
3	Autoimmune hemolytic anemia (HP:0001890)	6.54687793
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	5.79251435
5	Visual hallucinations (HP:0002367)	5.66462903
6	Increased cerebral lipofuscin (HP:0011813)	5.62092680
7	Testicular atrophy (HP:0000029)	5.35295052
8	Tetraparesis (HP:0002273)	5.07087646
9	Spastic diplegia (HP:0001264)	5.03253768
10	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.67869080
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.67869080
12	Acute necrotizing encephalopathy (HP:0006965)	3.65864814
13	Prostate neoplasm (HP:0100787)	3.46468190
14	Abnormality of T cell physiology (HP:0011840)	3.45860365
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.41636416
16	Mitochondrial inheritance (HP:0001427)	3.19104728
17	Increased hepatocellular lipid droplets (HP:0006565)	3.07110652
18	Increased CSF lactate (HP:0002490)	2.95843227
19	Opisthotonus (HP:0002179)	2.94299697
20	Acute encephalopathy (HP:0006846)	2.89242640
21	Chronic mucocutaneous candidiasis (HP:0002728)	2.88427771
22	Recurrent cutaneous fungal infections (HP:0011370)	2.88427771
23	Progressive macrocephaly (HP:0004481)	2.86564782
24	Abnormality of purine metabolism (HP:0004352)	2.82991380
25	Dyschromatopsia (HP:0007641)	2.80606702
26	Abnormal auditory evoked potentials (HP:0006958)	2.73240499
27	Lipid accumulation in hepatocytes (HP:0006561)	2.71579732
28	Hepatic necrosis (HP:0002605)	2.66198795
29	Abnormality of placental membranes (HP:0011409)	2.58273590
30	Amniotic constriction ring (HP:0009775)	2.58273590
31	Hepatocellular necrosis (HP:0001404)	2.58071317
32	Methylmalonic acidemia (HP:0002912)	2.57427725
33	Cheilitis (HP:0100825)	2.53529536
34	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.51550017
35	Gout (HP:0001997)	2.51448915
36	Abnormality of the prostate (HP:0008775)	2.50101077
37	Cerebral edema (HP:0002181)	2.45964874
38	Hypoplastic pelvis (HP:0008839)	2.43945365
39	Parakeratosis (HP:0001036)	2.42613624
40	Congenital, generalized hypertrichosis (HP:0004540)	2.41850818
41	Nausea (HP:0002018)	2.40949948
42	Central scotoma (HP:0000603)	2.38575504
43	Renal Fanconi syndrome (HP:0001994)	2.36082540
44	Reduced antithrombin III activity (HP:0001976)	2.32402309
45	Increased intramyocellular lipid droplets (HP:0012240)	2.29937426
46	Exertional dyspnea (HP:0002875)	2.29182119
47	Abnormality of T cells (HP:0002843)	2.28533612
48	Median cleft lip (HP:0000161)	2.23326061
49	Lower limb hyperreflexia (HP:0002395)	2.17891057
50	Generalized aminoaciduria (HP:0002909)	2.17741261
51	Supernumerary spleens (HP:0009799)	2.14443441
52	Type I transferrin isoform profile (HP:0003642)	2.13287614
53	Hypoproteinemia (HP:0003075)	2.11850862
54	Keratoconjunctivitis (HP:0001096)	2.10328162
55	Insidious onset (HP:0003587)	2.08041562
56	Termporal pattern (HP:0011008)	2.08041562
57	Increased serum lactate (HP:0002151)	2.07299343
58	Abnormal protein glycosylation (HP:0012346)	2.07193108
59	Abnormal glycosylation (HP:0012345)	2.07193108
60	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.07193108
61	Abnormal protein N-linked glycosylation (HP:0012347)	2.07193108
62	Lethargy (HP:0001254)	2.05823824
63	IgG deficiency (HP:0004315)	2.04088083
64	Congenital stationary night blindness (HP:0007642)	2.03525075
65	Cerebral hypomyelination (HP:0006808)	2.02036241
66	Palpitations (HP:0001962)	2.01735126
67	Megaloblastic anemia (HP:0001889)	1.98232286
68	Abnormality of B cell number (HP:0010975)	1.97930462
69	Abnormal spermatogenesis (HP:0008669)	1.97648078
70	Asplenia (HP:0001746)	1.95641945
71	Hypoplasia of the uterus (HP:0000013)	1.95344356
72	Rough bone trabeculation (HP:0100670)	1.93725933
73	Selective tooth agenesis (HP:0001592)	1.93434553
74	Lactic acidosis (HP:0003128)	1.92556069
75	Adrenal hypoplasia (HP:0000835)	1.89647179
76	Abnormality of nucleobase metabolism (HP:0010932)	1.89494857
77	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.89351577
78	Respiratory failure (HP:0002878)	1.86899009
79	B lymphocytopenia (HP:0010976)	1.85322393
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84243257
81	Abnormality of alanine metabolism (HP:0010916)	1.84243257
82	Hyperalaninemia (HP:0003348)	1.84243257
83	Conjunctival hamartoma (HP:0100780)	1.83142860
84	Aplasia/hypoplasia of the uterus (HP:0008684)	1.81936158
85	Methylmalonic aciduria (HP:0012120)	1.81581343
86	Increased muscle lipid content (HP:0009058)	1.80950512
87	Recurrent viral infections (HP:0004429)	1.80616565
88	Abnormality of methionine metabolism (HP:0010901)	1.79959882
89	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.79806290
90	Lymphoma (HP:0002665)	1.79615394
91	Exercise intolerance (HP:0003546)	1.78979897
92	Congenital ichthyosiform erythroderma (HP:0007431)	1.78821528
93	Progressive sensorineural hearing impairment (HP:0000408)	1.78754077
94	Pelvic girdle muscle weakness (HP:0003749)	1.77515685
95	Delayed CNS myelination (HP:0002188)	1.77016567
96	Redundant skin (HP:0001582)	1.75727642
97	Shoulder girdle muscle weakness (HP:0003547)	1.71309782
98	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.71061725
99	Renal cortical cysts (HP:0000803)	1.68141186
100	Recurrent fungal infections (HP:0002841)	1.67386431

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	7.50732557
2	BUB1	3.38137707
3	TXK	3.18602307
4	TSSK6	2.97924967
5	EIF2AK3	2.65428863
6	NME2	2.62009803
7	TAOK3	2.60352769
8	ZAK	2.36537681
9	PLK4	2.33627253
10	EIF2AK1	2.32109712
11	MAP4K1	2.06282093
12	MAP3K12	2.04706951
13	STK16	1.97626541
14	MST4	1.84620805
15	BMPR2	1.79663891
16	SRPK1	1.65039536
17	PLK3	1.64264701
18	MAP3K14	1.60022773
19	STK39	1.55826104
20	VRK2	1.55057656
21	WEE1	1.53724878
22	NUAK1	1.53558871
23	TRIM28	1.51728343
24	BCKDK	1.44044910
25	TLK1	1.39782518
26	CDC7	1.31021843
27	OXSR1	1.29392631
28	WNK4	1.27900969
29	IKBKB	1.22838688
30	AKT3	1.20830213
31	MYLK	1.18168118
32	EIF2AK2	1.02963748
33	PNCK	1.02934344
34	ADRBK2	1.02157675
35	TESK2	1.01061545
36	TTK	1.00586572
37	TBK1	0.95307764
38	ACVR1B	0.93820710
39	PLK1	0.93477634
40	FES	0.91981978
41	ATR	0.91978798
42	TIE1	0.91096380
43	IKBKE	0.86452765
44	GRK1	0.86109385
45	VRK1	0.84395272
46	CHEK2	0.81566073
47	PHKG1	0.80543866
48	PHKG2	0.80543866
49	CCNB1	0.80271685
50	BLK	0.78847624
51	KDR	0.70422568
52	IRAK1	0.70241550
53	DAPK1	0.69569377
54	JAK3	0.68009564
55	AURKB	0.66474806
56	CSNK2A1	0.63922255
57	CAMK2D	0.62641876
58	BRSK1	0.62244085
59	ABL2	0.61542033
60	ATM	0.60658475
61	LIMK1	0.57065640
62	ALK	0.56887233
63	CSNK2A2	0.56196239
64	IRAK4	0.56125285
65	BTK	0.54343908
66	CSNK1A1	0.54113743
67	PAK4	0.53752646
68	TEC	0.52655879
69	CSNK1A1L	0.49866061
70	GRK7	0.49161961
71	WNK3	0.49028492
72	TRPM7	0.48994263
73	CAMK2G	0.47586791
74	STK10	0.47473430
75	CAMKK2	0.45400603
76	MAP3K8	0.43979738
77	IRAK2	0.43769416
78	RPS6KB1	0.43675549
79	BRSK2	0.42761668
80	EPHA2	0.41488735
81	CSF1R	0.41031850
82	CHEK1	0.40771803
83	SYK	0.39859300
84	ABL1	0.39694948
85	CAMK2A	0.39645713
86	MOS	0.39429839
87	ILK	0.38775742
88	PIK3CA	0.37591212
89	MAP2K6	0.37250083
90	NME1	0.36241040
91	WNK1	0.35630383
92	AURKA	0.35496625
93	GSK3A	0.34604785
94	ZAP70	0.33671785
95	LYN	0.33138062
96	STK3	0.32817999
97	IGF1R	0.32259778
98	OBSCN	0.32109553
99	MAP3K11	0.30773113
100	LCK	0.29856880

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.00148466
2	Mismatch repair_Homo sapiens_hsa03430	3.25108298
3	Caffeine metabolism_Homo sapiens_hsa00232	2.94448069
4	DNA replication_Homo sapiens_hsa03030	2.85875241
5	Homologous recombination_Homo sapiens_hsa03440	2.75093618
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68087685
7	Asthma_Homo sapiens_hsa05310	2.56738206
8	Protein export_Homo sapiens_hsa03060	2.52541124
9	Parkinsons disease_Homo sapiens_hsa05012	2.39276212
10	Spliceosome_Homo sapiens_hsa03040	2.28040059
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.27697662
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.07945016
13	Allograft rejection_Homo sapiens_hsa05330	1.97299718
14	Ribosome_Homo sapiens_hsa03010	1.93679626
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.92537592
16	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.91195973
17	RNA polymerase_Homo sapiens_hsa03020	1.83497060
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.78381406
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.68628478
20	Huntingtons disease_Homo sapiens_hsa05016	1.66217654
21	RNA degradation_Homo sapiens_hsa03018	1.66162644
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65396835
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63146925
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.62261736
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.60876812
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57324777
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.54631868
28	One carbon pool by folate_Homo sapiens_hsa00670	1.54247782
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.51964512
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.50282815
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.49291806
32	Alzheimers disease_Homo sapiens_hsa05010	1.48512102
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48189827
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40234644
35	Purine metabolism_Homo sapiens_hsa00230	1.34960625
36	RNA transport_Homo sapiens_hsa03013	1.28233408
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.24474924
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.22989691
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.19416807
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14764245
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.13837233
42	Basal transcription factors_Homo sapiens_hsa03022	1.06003276
43	Propanoate metabolism_Homo sapiens_hsa00640	0.98597975
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97788301
45	Base excision repair_Homo sapiens_hsa03410	0.97611984
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.94173622
47	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.90241278
48	Sulfur metabolism_Homo sapiens_hsa00920	0.88668267
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88649633
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.85819561
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84352759
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84275266
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.83341828
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80802209
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75820455
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.73947778
57	Cell cycle_Homo sapiens_hsa04110	0.72637752
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72245054
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.72132139
60	Legionellosis_Homo sapiens_hsa05134	0.69494569
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68723469
62	Viral myocarditis_Homo sapiens_hsa05416	0.66444621
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.64530229
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62122108
65	Leishmaniasis_Homo sapiens_hsa05140	0.62069112
66	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.61282260
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59700502
68	Phototransduction_Homo sapiens_hsa04744	0.59504469
69	Glutathione metabolism_Homo sapiens_hsa00480	0.58323996
70	Metabolic pathways_Homo sapiens_hsa01100	0.56210404
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55918230
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53174753
73	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51110000
74	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46016952
75	HTLV-I infection_Homo sapiens_hsa05166	0.45587375
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.45437309
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.42468004
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42370536
79	Measles_Homo sapiens_hsa05162	0.40488542
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40442091
81	Herpes simplex infection_Homo sapiens_hsa05168	0.38801666
82	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.37988398
83	Carbon metabolism_Homo sapiens_hsa01200	0.37488305
84	Regulation of autophagy_Homo sapiens_hsa04140	0.37068766
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35794584
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35498563
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.34855824
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33412693
89	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32680762
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.30916962
91	p53 signaling pathway_Homo sapiens_hsa04115	0.26701238
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.24782708
93	Olfactory transduction_Homo sapiens_hsa04740	0.23083117
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.22797066
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.21354676
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.19777635
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.18772179
98	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.18380407
99	Folate biosynthesis_Homo sapiens_hsa00790	0.18117578
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.17824227

VDAC1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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