VDAC1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 2 cell differentiation (GO:0045628)9.90237373
2negative regulation of type 2 immune response (GO:0002829)9.86415585
3positive regulation of RNA splicing (GO:0033120)9.77330963
4activation of protein kinase A activity (GO:0034199)9.56583397
5negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.39235413
6seminiferous tubule development (GO:0072520)9.35663321
7negative regulation of alpha-beta T cell differentiation (GO:0046639)8.58898751
8detection of chemical stimulus involved in sensory perception (GO:0050907)8.42063926
9cAMP biosynthetic process (GO:0006171)8.33454599
10enteric nervous system development (GO:0048484)7.46822645
11regulation of protein sumoylation (GO:0033233)7.30814102
12positive regulation of mitochondrial fission (GO:0090141)7.21022385
13synaptic transmission, dopaminergic (GO:0001963)7.05605437
14righting reflex (GO:0060013)6.89194689
15dendritic spine morphogenesis (GO:0060997)6.83114975
16positive regulation of T-helper 1 type immune response (GO:0002827)6.47342216
17heterotypic cell-cell adhesion (GO:0034113)6.12432976
18hepatocyte apoptotic process (GO:0097284)6.10452067
19detection of chemical stimulus (GO:0009593)5.97997744
20icosanoid secretion (GO:0032309)5.82644837
21arachidonic acid secretion (GO:0050482)5.82644837
22endothelial cell differentiation (GO:0045446)5.66178813
23positive regulation of T-helper cell differentiation (GO:0045624)5.62352313
24phosphatidylinositol acyl-chain remodeling (GO:0036149)5.25357932
25regulation of mitochondrial fission (GO:0090140)5.21424436
26drug transmembrane transport (GO:0006855)5.20150132
27phosphatidylserine acyl-chain remodeling (GO:0036150)4.91114265
28negative regulation of alpha-beta T cell activation (GO:0046636)4.84973545
29neural tube formation (GO:0001841)4.79694121
30fatty acid derivative transport (GO:1901571)4.77727539
31icosanoid transport (GO:0071715)4.77727539
32regulation of T-helper 1 type immune response (GO:0002825)4.68984558
33phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.66983525
34attachment of spindle microtubules to kinetochore (GO:0008608)4.59511794
35chemosensory behavior (GO:0007635)4.59072658
36neuronal ion channel clustering (GO:0045161)4.50099029
37ATP hydrolysis coupled proton transport (GO:0015991)4.46119347
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.46119347
39embryonic digestive tract morphogenesis (GO:0048557)4.43183012
40regulation of T-helper cell differentiation (GO:0045622)4.40599485
41nephron epithelium morphogenesis (GO:0072088)4.29477646
42nephron tubule morphogenesis (GO:0072078)4.29477646
43positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.25247277
44cyclic purine nucleotide metabolic process (GO:0052652)4.23001944
45hyaluronan catabolic process (GO:0030214)4.22647752
46cyclic nucleotide biosynthetic process (GO:0009190)4.18090846
47cilium or flagellum-dependent cell motility (GO:0001539)4.17264638
48vocalization behavior (GO:0071625)4.11299403
49regulation of cAMP-mediated signaling (GO:0043949)4.10221900
50mitochondrial fusion (GO:0008053)4.05308572
51response to dietary excess (GO:0002021)4.05253287
52positive regulation of membrane potential (GO:0045838)4.03850590
53dendritic spine organization (GO:0097061)3.98500692
54cellular response to glucagon stimulus (GO:0071377)3.93581228
55cAMP metabolic process (GO:0046058)3.90490167
56protein localization to synapse (GO:0035418)3.90240075
57retina layer formation (GO:0010842)3.90208552
58negative regulation of actin filament bundle assembly (GO:0032232)3.89978616
59regulation of type 2 immune response (GO:0002828)3.84028371
60leukotriene biosynthetic process (GO:0019370)3.83920069
61negative regulation of T cell differentiation (GO:0045581)3.80754401
62water transport (GO:0006833)3.80346894
63positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.73139365
64reflex (GO:0060004)3.63320685
65cellular zinc ion homeostasis (GO:0006882)3.58861409
66monoamine transport (GO:0015844)3.55880068
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53584358
68drug transport (GO:0015893)3.52250068
69positive regulation of alpha-beta T cell differentiation (GO:0046638)3.49644924
70negative regulation of cytosolic calcium ion concentration (GO:0051481)3.47556181
71regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.45056916
72positive regulation of protein targeting to membrane (GO:0090314)3.43741704
73positive regulation of steroid hormone secretion (GO:2000833)3.42906059
74phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.41094846
75fluid transport (GO:0042044)3.38450607
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.31124839
77positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.30294314
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25788634
79cellular response to ATP (GO:0071318)3.24952265
80pre-miRNA processing (GO:0031054)3.24594263
81renal tubule morphogenesis (GO:0061333)3.22017213
82sequestering of metal ion (GO:0051238)3.21579481
83negative regulation of astrocyte differentiation (GO:0048712)3.16501793
84sulfur amino acid catabolic process (GO:0000098)3.13051844
85left/right axis specification (GO:0070986)3.12566788
86prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.10443483
87regulation of alpha-beta T cell differentiation (GO:0046637)3.08785075
88negative regulation of homotypic cell-cell adhesion (GO:0034111)3.02963360
89adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.02623585
90adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.02129029
91regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.99890952
92response to glucagon (GO:0033762)2.99740725
93regulation of relaxation of muscle (GO:1901077)2.98938784
94detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.3922424
95tooth mineralization (GO:0034505)13.3600208
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.7030797
97negative regulation of T-helper cell differentiation (GO:0045623)11.7030797
98positive regulation of protein sumoylation (GO:0033235)11.4505308
99protein K11-linked deubiquitination (GO:0035871)10.4609447
100regulation of T-helper 1 cell differentiation (GO:0045625)10.2954864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.57179193
2VDR_22108803_ChIP-Seq_LS180_Human5.43777441
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.16788148
4IGF1R_20145208_ChIP-Seq_DFB_Human5.03168038
5AR_21572438_ChIP-Seq_LNCaP_Human4.96697146
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.00962848
7PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06162290
8TP53_16413492_ChIP-PET_HCT116_Human2.02550567
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01980395
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse11.4141313
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99853962
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.99853962
13YY1_22570637_ChIP-Seq_MALME-3M_Human1.98301744
14NR3C1_23031785_ChIP-Seq_PC12_Mouse1.78185052
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71569860
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70130610
17GATA1_19941826_ChIP-Seq_K562_Human1.69809708
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66739283
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63342082
20EGR1_19032775_ChIP-ChIP_M12_Human1.52143240
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51768415
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.44660544
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.44590463
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43429499
25DROSHA_22980978_ChIP-Seq_HELA_Human1.42541313
26ER_23166858_ChIP-Seq_MCF-7_Human1.36696132
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33430861
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.32577639
29RXR_22108803_ChIP-Seq_LS180_Human1.32072427
30ZNF274_21170338_ChIP-Seq_K562_Hela1.32016091
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30187568
32TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.28665933
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.28346408
34RNF2_27304074_Chip-Seq_NSC_Mouse1.24032434
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.23341569
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21691950
37EZH2_22144423_ChIP-Seq_EOC_Human1.15105834
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15030878
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14199349
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.14113966
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12844571
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11431364
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11113680
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10303073
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09740882
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.08575901
47SOX2_18555785_Chip-Seq_ESCs_Mouse1.07495358
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04695165
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04466761
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.04443985
51GATA6_21074721_ChIP-Seq_CACO-2_Human1.03895212
52GBX2_23144817_ChIP-Seq_PC3_Human1.03698439
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.01981338
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01539771
55CMYC_18555785_Chip-Seq_ESCs_Mouse0.99536126
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98543526
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98399036
58FLI1_27457419_Chip-Seq_LIVER_Mouse0.97706723
59EZH2_27294783_Chip-Seq_ESCs_Mouse0.97454061
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96686807
61SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95735306
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94908858
63TBL1_22424771_ChIP-Seq_293T_Human0.94297631
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94144719
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93884126
66PHF8_20622853_ChIP-Seq_HELA_Human0.93874205
67STAT3_23295773_ChIP-Seq_U87_Human0.91712221
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91111719
69CBP_20019798_ChIP-Seq_JUKART_Human0.91111719
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91042705
71MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90841837
72SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90710683
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90527428
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90398957
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90095290
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89756035
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.89492777
78ESR2_21235772_ChIP-Seq_MCF-7_Human0.87822809
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87273982
80CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87068824
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86918150
82BCAT_22108803_ChIP-Seq_LS180_Human0.86735631
83SMAD4_21799915_ChIP-Seq_A2780_Human0.86524912
84KLF4_18555785_Chip-Seq_ESCs_Mouse0.85729841
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85034306
86CJUN_26792858_Chip-Seq_BT549_Human0.84851011
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.84661686
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83802248
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83728504
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.82171374
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.81812735
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81808822
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.81686964
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80420485
95P53_22387025_ChIP-Seq_ESCs_Mouse0.79772908
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79698742
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79157229
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77725196
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.77673272
100NANOG_20526341_ChIP-Seq_ESCs_Human0.77301839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.34065718
2MP0004130_abnormal_muscle_cell4.65349532
3MP0004264_abnormal_extraembryonic_tissu3.54941838
4MP0003252_abnormal_bile_duct3.44419784
5MP0004133_heterotaxia2.61923656
6MP0006072_abnormal_retinal_apoptosis2.56277794
7MP0002928_abnormal_bile_duct2.45253397
8MP0002751_abnormal_autonomic_nervous2.28217662
9MP0005408_hypopigmentation2.21370302
10MP0005448_abnormal_energy_balance2.13405181
11MP0005084_abnormal_gallbladder_morpholo12.4186997
12MP0001270_distended_abdomen1.88314094
13MP0005379_endocrine/exocrine_gland_phen1.69359983
14MP0001529_abnormal_vocalization1.64068349
15MP0004272_abnormal_basement_membrane1.60988307
16MP0003329_amyloid_beta_deposits1.60666521
17MP0003943_abnormal_hepatobiliary_system1.57518179
18MP0005165_increased_susceptibility_to1.51088151
19MP0005220_abnormal_exocrine_pancreas1.45423988
20MP0009764_decreased_sensitivity_to1.33151405
21MP0008875_abnormal_xenobiotic_pharmacok1.18018385
22MP0005646_abnormal_pituitary_gland1.16194435
23MP0001905_abnormal_dopamine_level1.15640277
24MP0003718_maternal_effect1.13571994
25MP0000604_amyloidosis1.07087557
26MP0003195_calcinosis1.04568451
27MP0000372_irregular_coat_pigmentation1.02360402
28MP0000470_abnormal_stomach_morphology1.01970888
29MP0001958_emphysema0.98786905
30MP0008569_lethality_at_weaning0.98573155
31MP0002572_abnormal_emotion/affect_behav0.97386855
32MP0002405_respiratory_system_inflammati0.96845534
33MP0005387_immune_system_phenotype0.93068057
34MP0001790_abnormal_immune_system0.93068057
35MP0000465_gastrointestinal_hemorrhage0.91560478
36MP0003866_abnormal_defecation0.89742420
37MP0003638_abnormal_response/metabolism_0.86254062
38MP0002909_abnormal_adrenal_gland0.83723272
39MP0001800_abnormal_humoral_immune0.83406011
40MP0005253_abnormal_eye_physiology0.81848486
41MP0001944_abnormal_pancreas_morphology0.80726619
42MP0004019_abnormal_vitamin_homeostasis0.79552491
43MP0000703_abnormal_thymus_morphology0.79356348
44MP0008469_abnormal_protein_level0.77196219
45MP0004145_abnormal_muscle_electrophysio0.75740937
46MP0002254_reproductive_system_inflammat0.75304288
47MP0000759_abnormal_skeletal_muscle0.74348737
48MP0004947_skin_inflammation0.71254313
49MP0000609_abnormal_liver_physiology0.71060109
50MP0002822_catalepsy0.67795705
51MP0004381_abnormal_hair_follicle0.67358991
52MP0002736_abnormal_nociception_after0.66092835
53MP0001835_abnormal_antigen_presentation0.65697172
54MP0001533_abnormal_skeleton_physiology0.64597270
55MP0000371_diluted_coat_color0.64080444
56MP0002098_abnormal_vibrissa_morphology0.61770415
57MP0003121_genomic_imprinting0.61327191
58MP0001915_intracranial_hemorrhage0.60889569
59MP0002136_abnormal_kidney_physiology0.60067994
60MP0004484_altered_response_of0.58932981
61MP0002138_abnormal_hepatobiliary_system0.56546495
62MP0002722_abnormal_immune_system0.55393835
63MP0002693_abnormal_pancreas_physiology0.54083649
64MP0003953_abnormal_hormone_level0.52600856
65MP0001502_abnormal_circadian_rhythm0.51168026
66MP0009785_altered_susceptibility_to0.51082351
67MP0003763_abnormal_thymus_physiology0.50196982
68MP0005671_abnormal_response_to0.49524890
69MP0002078_abnormal_glucose_homeostasis0.48976132
70MP0001542_abnormal_bone_strength0.48967692
71MP0001845_abnormal_inflammatory_respons0.48820867
72MP0004036_abnormal_muscle_relaxation0.48744487
73MP0005551_abnormal_eye_electrophysiolog0.48123305
74MP0003646_muscle_fatigue0.47969262
75MP0005645_abnormal_hypothalamus_physiol0.46888682
76MP0003436_decreased_susceptibility_to0.46649399
77MP0002106_abnormal_muscle_physiology0.44755789
78MP0001501_abnormal_sleep_pattern0.43675125
79MP0001968_abnormal_touch/_nociception0.43606202
80MP0005360_urolithiasis0.42570808
81MP0002723_abnormal_immune_serum0.41725286
82MP0002638_abnormal_pupillary_reflex0.41359516
83MP0002452_abnormal_antigen_presenting0.41151091
84MP0001819_abnormal_immune_cell0.40412778
85MP0002420_abnormal_adaptive_immunity0.40168913
86MP0002229_neurodegeneration0.39300555
87MP0006276_abnormal_autonomic_nervous0.39107650
88MP0001851_eye_inflammation0.39053083
89MP0005164_abnormal_response_to0.38526045
90MP0004147_increased_porphyrin_level0.36866023
91MP0009642_abnormal_blood_homeostasis0.36727841
92MP0002429_abnormal_blood_cell0.36713263
93MP0003136_yellow_coat_color0.36623445
94MP0005000_abnormal_immune_tolerance0.36565768
95MP0005620_abnormal_muscle_contractility0.36148206
96MP0002998_abnormal_bone_remodeling0.35715697
97MP0000716_abnormal_immune_system0.35150736
98MP0005167_abnormal_blood-brain_barrier0.34805574
99MP0005334_abnormal_fat_pad0.34315744
100MP0000477_abnormal_intestine_morphology0.33092134

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.50145790
2Abnormality of dental color (HP:0011073)7.70683271
3Abnormality of renal resorption (HP:0011038)7.63019501
4Polyuria (HP:0000103)7.26034886
5Osteomalacia (HP:0002749)6.81374984
6Abnormality of the dental pulp (HP:0006479)6.77627024
7Round ear (HP:0100830)6.58764130
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.27776373
9Abnormal urine output (HP:0012590)6.19326491
10Autoimmune thrombocytopenia (HP:0001973)5.70331620
11Abnormality of renal excretion (HP:0011036)5.33039008
12Chronic bronchitis (HP:0004469)4.62657302
13Volvulus (HP:0002580)4.33527155
14Toxemia of pregnancy (HP:0100603)4.24960024
15IgM deficiency (HP:0002850)4.04081328
16Lip pit (HP:0100267)4.00710784
17Molar tooth sign on MRI (HP:0002419)3.87605830
18Abnormality of midbrain morphology (HP:0002418)3.87605830
19Lipoatrophy (HP:0100578)3.42667635
20Nephrocalcinosis (HP:0000121)3.40873091
21Depressed nasal tip (HP:0000437)3.33725904
22Rhinitis (HP:0012384)3.23778163
23Esophageal varix (HP:0002040)3.15469115
24Abnormal respiratory motile cilium physiology (HP:0012261)3.04620816
25Tachypnea (HP:0002789)3.02484462
26Drooling (HP:0002307)3.01330351
27Hyperphosphaturia (HP:0003109)2.95696424
28Large earlobe (HP:0009748)2.93997405
29Excessive salivation (HP:0003781)2.85739861
30Hypoparathyroidism (HP:0000829)2.85453822
31Abnormality of the fingertips (HP:0001211)2.78705606
32Sparse lateral eyebrow (HP:0005338)2.77645512
33Nephronophthisis (HP:0000090)2.69865762
34Inability to walk (HP:0002540)2.65048797
35Panhypogammaglobulinemia (HP:0003139)2.63480526
36Autoimmune hemolytic anemia (HP:0001890)2.56531483
37Thick eyebrow (HP:0000574)2.53783518
38Mask-like facies (HP:0000298)2.53509018
39Glycosuria (HP:0003076)2.43116325
40Abnormality of urine glucose concentration (HP:0011016)2.43116325
41Dilated cardiomyopathy (HP:0001644)2.42333672
42Abnormal urine phosphate concentration (HP:0012599)2.40934404
43Intestinal fistula (HP:0100819)2.40063832
44Recurrent cutaneous fungal infections (HP:0011370)2.38839456
45Chronic mucocutaneous candidiasis (HP:0002728)2.38839456
46Ureteral stenosis (HP:0000071)2.26315049
47Abnormality of transition element cation homeostasis (HP:0011030)2.25757600
48Hepatitis (HP:0012115)2.12123565
49Personality changes (HP:0000751)2.11448488
50Decreased muscle mass (HP:0003199)2.10955788
51Nephropathy (HP:0000112)2.10513038
52Ureteral obstruction (HP:0006000)2.08640983
53Bronchitis (HP:0012387)2.08398110
54Striae distensae (HP:0001065)2.06051254
55Overgrowth (HP:0001548)11.0486842
56Amelogenesis imperfecta (HP:0000705)10.7980783
57Hypercalciuria (HP:0002150)1.94766724
58Abnormality of salivation (HP:0100755)1.93373230
59Gingival overgrowth (HP:0000212)1.91766653
60Abnormality of the renal medulla (HP:0100957)1.91156104
61Anal stenosis (HP:0002025)1.90514890
62Distal arthrogryposis (HP:0005684)1.89005074
63Petechiae (HP:0000967)1.86020305
64Sudden cardiac death (HP:0001645)1.85332969
65Short 5th finger (HP:0009237)1.84863417
66Nemaline bodies (HP:0003798)1.84529424
67Abnormal delayed hypersensitivity skin test (HP:0002963)1.84010989
68Small hand (HP:0200055)1.82508253
69Delayed eruption of teeth (HP:0000684)1.81851080
70Periauricular skin pits (HP:0100277)1.81424080
71Preauricular pit (HP:0004467)1.81424080
72Chorioretinal coloboma (HP:0000567)1.80165345
73Recurrent otitis media (HP:0000403)1.80044182
74Prominent supraorbital ridges (HP:0000336)1.79485179
75Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.78633540
76Visual hallucinations (HP:0002367)1.78121612
77Chondrocalcinosis (HP:0000934)1.76885034
78Muscle fiber inclusion bodies (HP:0100299)1.75140348
79Elevated erythrocyte sedimentation rate (HP:0003565)1.74591697
80Renal tubular dysfunction (HP:0000124)1.73845804
81Abnormality of Sharpey fibers (HP:0100685)1.73613737
82Preauricular skin tag (HP:0000384)1.71686335
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.67339865
84Ectopic kidney (HP:0000086)1.63535532
85Polyneuropathy (HP:0001271)1.59547146
86Absent phalangeal crease (HP:0006109)1.59263562
87Congenital stationary night blindness (HP:0007642)1.58094737
88Testicular atrophy (HP:0000029)1.57257260
89Abnormality of the fovea (HP:0000493)1.55415610
90Abnormality of T cell physiology (HP:0011840)1.54111346
91Palpebral edema (HP:0100540)1.51244368
92Palmoplantar keratoderma (HP:0000982)1.50768272
93Bronchiectasis (HP:0002110)1.50167653
94Skin tags (HP:0010609)1.48435470
95Delayed gross motor development (HP:0002194)1.47337870
96Calcaneovalgus deformity (HP:0001848)1.46904329
97Stage 5 chronic kidney disease (HP:0003774)1.44785937
98Blepharitis (HP:0000498)1.44740804
99Abnormality of purine metabolism (HP:0004352)1.42564272
100Limited elbow extension (HP:0001377)1.42195716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.68239869
2BLK3.78490539
3STK33.69258008
4RIPK42.43163892
5BMPR22.30412597
6NEK12.06706929
7NTRK213.3965636
8CDC42BPA1.70885600
9MUSK1.64958734
10OBSCN1.19006676
11TXK1.18094842
12WNK41.09570130
13HIPK21.05380720
14TIE11.04547670
15PHKG21.03622777
16PHKG11.03622777
17FGFR10.99289781
18TLK10.84471425
19ADRBK20.78582506
20SRPK10.75558881
21ZAK0.72820346
22VRK10.69799371
23INSRR0.61926839
24ROCK20.59750492
25PRKAA10.58416834
26SRC0.57906735
27SYK0.56671205
28WNK30.52329725
29IKBKB0.49988548
30GRK10.49354728
31PRKCQ0.48755910
32CCNB10.48706189
33CHUK0.48431188
34PRKACB0.47710911
35STK390.46331375
36PRKACG0.44350241
37TEC0.42102874
38IKBKE0.41910762
39PRKACA0.40817069
40ROCK10.40639780
41ABL10.40300272
42CAMK2A0.39636229
43OXSR10.35211713
44PIK3CA0.34703079
45PIK3CG0.34655554
46GRK60.33690365
47IRAK10.33103712
48MAP4K20.32515359
49TSSK60.32464351
50CAMK2G0.31224265
51FRK0.30678985
52MAP2K70.30637787
53MAPK130.29434777
54GRK70.28828872
55ABL20.27129287
56MAP3K40.25895444
57PLK10.25741940
58VRK20.23956547
59EPHA30.23807793
60PRKCA0.23443010
61GSK3B0.23364616
62CSNK1A10.23160793
63PINK10.22209557
64MAPK140.21917796
65MAPK150.21303359
66RPS6KA30.20911909
67PKN10.20052930
68ITK0.19961101
69LYN0.19959928
70CAMK2D0.19288626
71MAPK90.18680731
72PRKCB0.18225542
73MARK10.16941698
74FER0.16760718
75PRKD30.15383574
76RPS6KA50.14874563
77CDK10.14619147
78PRKCD0.14263933
79TRIM280.14212391
80PRKG10.13657341
81ERBB40.13033807
82WNK10.12756104
83PRKCE0.11855921
84LMTK20.11724893
85CHEK20.11240995
86LATS10.11205576
87EGFR0.10645512
88AURKA0.10420792
89FYN0.10242039
90DYRK30.10050038
91LCK0.09590465
92ADRBK10.08948480
93IGF1R0.08816125
94MAP3K50.08708984
95PIM10.08549961
96CSNK1G10.08285353
97CSNK1G30.08074749
98CSNK1G20.07838982
99BTK0.07683355
100PRKDC0.07468378

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.42693929
2Sulfur metabolism_Homo sapiens_hsa009203.85763824
3Sulfur relay system_Homo sapiens_hsa041223.50352005
4Ovarian steroidogenesis_Homo sapiens_hsa049133.17403556
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.00365629
6Linoleic acid metabolism_Homo sapiens_hsa005912.81643518
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.70504876
8Collecting duct acid secretion_Homo sapiens_hsa049662.58104493
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.43061615
10Vibrio cholerae infection_Homo sapiens_hsa051102.40580745
11Bile secretion_Homo sapiens_hsa049762.25089698
12Salivary secretion_Homo sapiens_hsa049702.13413870
13Synaptic vesicle cycle_Homo sapiens_hsa047212.11340317
14Thyroid hormone synthesis_Homo sapiens_hsa049182.10414791
15Fat digestion and absorption_Homo sapiens_hsa049752.09630266
16Gastric acid secretion_Homo sapiens_hsa049712.08881204
17Pancreatic secretion_Homo sapiens_hsa049722.07643575
18Circadian entrainment_Homo sapiens_hsa047131.90618491
19Cocaine addiction_Homo sapiens_hsa050301.89893919
20Taste transduction_Homo sapiens_hsa047421.83192648
21Insulin secretion_Homo sapiens_hsa049111.79848765
22Morphine addiction_Homo sapiens_hsa050321.74567026
23Ether lipid metabolism_Homo sapiens_hsa005651.74407325
24GABAergic synapse_Homo sapiens_hsa047271.71947321
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71864386
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.68326659
27Dilated cardiomyopathy_Homo sapiens_hsa054141.67519976
28Glutamatergic synapse_Homo sapiens_hsa047241.56925663
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50821925
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48510197
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.44488651
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44085907
33Amphetamine addiction_Homo sapiens_hsa050311.38889971
34Gap junction_Homo sapiens_hsa045401.34836042
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26877315
36Circadian rhythm_Homo sapiens_hsa047101.26548480
37Arachidonic acid metabolism_Homo sapiens_hsa005901.22289510
38Oxytocin signaling pathway_Homo sapiens_hsa049211.20042627
39Melanogenesis_Homo sapiens_hsa049161.18267768
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15376586
41GnRH signaling pathway_Homo sapiens_hsa049121.14179264
42Calcium signaling pathway_Homo sapiens_hsa040201.10035906
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07929563
44Systemic lupus erythematosus_Homo sapiens_hsa053221.07429700
45Cholinergic synapse_Homo sapiens_hsa047251.06705142
46Alcoholism_Homo sapiens_hsa050341.01862336
47Platelet activation_Homo sapiens_hsa046111.00499638
48Estrogen signaling pathway_Homo sapiens_hsa049150.95731004
49Oocyte meiosis_Homo sapiens_hsa041140.90930722
50RNA degradation_Homo sapiens_hsa030180.89176140
51Pyruvate metabolism_Homo sapiens_hsa006200.82679338
52Serotonergic synapse_Homo sapiens_hsa047260.77693348
53Rheumatoid arthritis_Homo sapiens_hsa053230.77243442
54Dorso-ventral axis formation_Homo sapiens_hsa043200.75526196
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74435398
56Parkinsons disease_Homo sapiens_hsa050120.72252238
57Caffeine metabolism_Homo sapiens_hsa002320.71905311
58Chemokine signaling pathway_Homo sapiens_hsa040620.61283836
59Oxidative phosphorylation_Homo sapiens_hsa001900.56672183
60Primary immunodeficiency_Homo sapiens_hsa053400.55894748
61Dopaminergic synapse_Homo sapiens_hsa047280.51695590
62Purine metabolism_Homo sapiens_hsa002300.51149807
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45585672
64ECM-receptor interaction_Homo sapiens_hsa045120.44687358
65Viral carcinogenesis_Homo sapiens_hsa052030.40131479
66cAMP signaling pathway_Homo sapiens_hsa040240.39076479
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38832812
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37083836
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.33388183
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29606237
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26306050
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.25469673
73Nitrogen metabolism_Homo sapiens_hsa009100.20538415
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19397865
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16519558
76Glucagon signaling pathway_Homo sapiens_hsa049220.15906055
77Phototransduction_Homo sapiens_hsa047440.15810227
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15613431
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14690370
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.14520352
81HTLV-I infection_Homo sapiens_hsa051660.14124329
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13127013
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.13037277
84Proteasome_Homo sapiens_hsa030500.13027172
85Type I diabetes mellitus_Homo sapiens_hsa049400.12291006
86Chemical carcinogenesis_Homo sapiens_hsa052040.11953968
87Antigen processing and presentation_Homo sapiens_hsa046120.10469765
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09442705
89Retinol metabolism_Homo sapiens_hsa008300.09346688
90Staphylococcus aureus infection_Homo sapiens_hsa051500.09118082
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.08267051
92Nicotine addiction_Homo sapiens_hsa050330.06855905
93Phagosome_Homo sapiens_hsa041450.06723657
94Hedgehog signaling pathway_Homo sapiens_hsa043400.06356527
95Rap1 signaling pathway_Homo sapiens_hsa040150.05713243
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.05686742
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.04514984
98Tuberculosis_Homo sapiens_hsa051520.03431040
99Autoimmune thyroid disease_Homo sapiens_hsa053200.02001823
100Renin secretion_Homo sapiens_hsa049240.01749815

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