VDAC1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activation of protein kinase A activity (GO:0034199)9.87121432
2negative regulation of type 2 immune response (GO:0002829)9.79763818
3regulation of T-helper 2 cell differentiation (GO:0045628)9.75098358
4positive regulation of RNA splicing (GO:0033120)9.46692241
5negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)9.44598159
6seminiferous tubule development (GO:0072520)9.40878594
7cAMP biosynthetic process (GO:0006171)8.67408583
8negative regulation of alpha-beta T cell differentiation (GO:0046639)8.46133889
9detection of chemical stimulus involved in sensory perception (GO:0050907)8.45977815
10enteric nervous system development (GO:0048484)7.71056109
11regulation of protein sumoylation (GO:0033233)7.35015546
12synaptic transmission, dopaminergic (GO:0001963)7.15135402
13positive regulation of mitochondrial fission (GO:0090141)7.03598134
14righting reflex (GO:0060013)6.95440663
15dendritic spine morphogenesis (GO:0060997)6.94024335
16positive regulation of T-helper 1 type immune response (GO:0002827)6.52971331
17heterotypic cell-cell adhesion (GO:0034113)6.38688128
18detection of chemical stimulus (GO:0009593)6.07713685
19hepatocyte apoptotic process (GO:0097284)5.97923773
20icosanoid secretion (GO:0032309)5.93817995
21arachidonic acid secretion (GO:0050482)5.93817995
22endothelial cell differentiation (GO:0045446)5.79292187
23positive regulation of T-helper cell differentiation (GO:0045624)5.69021711
24phosphatidylinositol acyl-chain remodeling (GO:0036149)5.45303995
25regulation of mitochondrial fission (GO:0090140)5.17863235
26drug transmembrane transport (GO:0006855)5.16775800
27phosphatidylserine acyl-chain remodeling (GO:0036150)5.05207935
28negative regulation of alpha-beta T cell activation (GO:0046636)5.04983521
29icosanoid transport (GO:0071715)4.88166641
30fatty acid derivative transport (GO:1901571)4.88166641
31phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.84162988
32neuronal ion channel clustering (GO:0045161)4.73242058
33regulation of T-helper 1 type immune response (GO:0002825)4.72208315
34neural tube formation (GO:0001841)4.70919755
35chemosensory behavior (GO:0007635)4.61003705
36energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.52202864
37ATP hydrolysis coupled proton transport (GO:0015991)4.52202864
38hyaluronan catabolic process (GO:0030214)4.47230725
39embryonic digestive tract morphogenesis (GO:0048557)4.46349664
40cilium or flagellum-dependent cell motility (GO:0001539)4.44781618
41attachment of spindle microtubules to kinetochore (GO:0008608)4.43758870
42nephron epithelium morphogenesis (GO:0072088)4.42967319
43nephron tubule morphogenesis (GO:0072078)4.42967319
44vocalization behavior (GO:0071625)4.42535190
45positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.33736506
46positive regulation of membrane potential (GO:0045838)4.32217416
47regulation of T-helper cell differentiation (GO:0045622)4.31010693
48cyclic purine nucleotide metabolic process (GO:0052652)4.29219027
49response to dietary excess (GO:0002021)4.28311580
50retina layer formation (GO:0010842)4.23427836
51cyclic nucleotide biosynthetic process (GO:0009190)4.17221309
52cellular response to glucagon stimulus (GO:0071377)4.13212578
53regulation of type 2 immune response (GO:0002828)4.03538798
54regulation of cAMP-mediated signaling (GO:0043949)4.02685117
55negative regulation of actin filament bundle assembly (GO:0032232)4.01975391
56cAMP metabolic process (GO:0046058)4.00025109
57water transport (GO:0006833)3.95429791
58mitochondrial fusion (GO:0008053)3.94621381
59protein localization to synapse (GO:0035418)3.92920340
60negative regulation of T cell differentiation (GO:0045581)3.91677486
61positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.88627844
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.86338903
63dendritic spine organization (GO:0097061)3.85676762
64cellular zinc ion homeostasis (GO:0006882)3.76433155
65monoamine transport (GO:0015844)3.75130476
66leukotriene biosynthetic process (GO:0019370)3.70320394
67drug transport (GO:0015893)3.60333631
68cellular response to ATP (GO:0071318)3.59098701
69positive regulation of protein targeting to membrane (GO:0090314)3.59003940
70phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.57511349
71fluid transport (GO:0042044)3.51659012
72pre-miRNA processing (GO:0031054)3.47476809
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.44122790
74sequestering of metal ion (GO:0051238)3.41901324
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.39462706
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38659469
77positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.36149102
78sulfur amino acid catabolic process (GO:0000098)3.31110351
79neurofilament cytoskeleton organization (GO:0060052)3.28084297
80positive regulation of alpha-beta T cell differentiation (GO:0046638)3.27651353
81left/right axis specification (GO:0070986)3.24243285
82negative regulation of astrocyte differentiation (GO:0048712)3.17038359
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16969381
84renal tubule morphogenesis (GO:0061333)3.15675944
85negative regulation of homotypic cell-cell adhesion (GO:0034111)3.14313067
86reflex (GO:0060004)3.14238586
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13680657
88neuromuscular process controlling posture (GO:0050884)3.11852964
89response to glucagon (GO:0033762)3.09984381
90phosphatidylcholine acyl-chain remodeling (GO:0036151)3.09424143
91adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.03060526
92prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.03044820
93negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.02849173
94tooth mineralization (GO:0034505)13.9394009
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)13.5445963
96positive regulation of protein sumoylation (GO:0033235)11.6801805
97negative regulation of T-helper cell differentiation (GO:0045623)11.5666856
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)11.5666856
99protein K11-linked deubiquitination (GO:0035871)10.3639246
100regulation of T-helper 1 cell differentiation (GO:0045625)10.2028854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.30064912
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.33467273
3IGF1R_20145208_ChIP-Seq_DFB_Human4.92246461
4AR_21572438_ChIP-Seq_LNCaP_Human4.66374886
5VDR_22108803_ChIP-Seq_LS180_Human4.56241574
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.38256546
7TP53_16413492_ChIP-PET_HCT116_Human2.16306670
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.10771727
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.6102229
10YY1_22570637_ChIP-Seq_MALME-3M_Human1.93220552
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86566718
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.86566718
13ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80631677
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76721738
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76088515
16NR3C1_23031785_ChIP-Seq_PC12_Mouse1.74194701
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65561523
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65272342
19GATA1_19941826_ChIP-Seq_K562_Human1.62203085
20DROSHA_22980978_ChIP-Seq_HELA_Human1.60746962
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52776715
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52343287
23EGR1_19032775_ChIP-ChIP_M12_Human1.50866721
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.47504582
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.47455701
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.43176003
27SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41681096
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.38601507
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.35409139
30GBX2_23144817_ChIP-Seq_PC3_Human1.33048424
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30019971
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27636282
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27529600
34RXR_22108803_ChIP-Seq_LS180_Human1.26428312
35RNF2_27304074_Chip-Seq_NSC_Mouse1.26054946
36TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.24530625
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19957255
38ZNF274_21170338_ChIP-Seq_K562_Hela1.19734057
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.19538635
40ER_23166858_ChIP-Seq_MCF-7_Human1.18821627
41SOX2_18555785_Chip-Seq_ESCs_Mouse1.14536291
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13123318
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12826556
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11596540
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.10837809
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.10316311
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09878051
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08818817
49EZH2_22144423_ChIP-Seq_EOC_Human1.08460440
50GATA6_21074721_ChIP-Seq_CACO-2_Human1.06435471
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.05898940
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.05872843
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05421506
54BCAT_22108803_ChIP-Seq_LS180_Human1.04823069
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04539876
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.02903463
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02870092
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.02181470
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01839578
60STAT3_23295773_ChIP-Seq_U87_Human1.01251674
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01129978
62SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99559249
63BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99461742
64SMAD4_21741376_ChIP-Seq_HESCs_Human0.98467532
65SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98339636
66PHF8_20622853_ChIP-Seq_HELA_Human0.98316263
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97631229
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97351210
69TBL1_22424771_ChIP-Seq_293T_Human0.97317482
70ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97307105
71EZH2_27294783_Chip-Seq_NPCs_Mouse0.94399156
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94040161
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93737438
74E2F1_18555785_Chip-Seq_ESCs_Mouse0.93346429
75NMYC_18555785_Chip-Seq_ESCs_Mouse0.93084078
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.92379258
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92109414
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91951804
79DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91930668
80KLF4_18555785_Chip-Seq_ESCs_Mouse0.91068226
81HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90716531
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90705973
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90657725
84CJUN_26792858_Chip-Seq_BT549_Human0.88954085
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88677999
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88564867
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88145917
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87052754
89P53_22387025_ChIP-Seq_ESCs_Mouse0.86776682
90CBP_20019798_ChIP-Seq_JUKART_Human0.86192886
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86192886
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85718069
93SMAD4_21799915_ChIP-Seq_A2780_Human0.85367128
94TCF4_22108803_ChIP-Seq_LS180_Human0.85111163
95REST_21632747_ChIP-Seq_MESCs_Mouse0.84592622
96NANOG_16518401_ChIP-PET_MESCs_Mouse0.84150945
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84019137
98NANOG_20526341_ChIP-Seq_ESCs_Human0.83441466
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81773950
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.81288867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism9.36751881
2MP0004130_abnormal_muscle_cell4.69850938
3MP0004264_abnormal_extraembryonic_tissu3.85791111
4MP0003252_abnormal_bile_duct3.63794535
5MP0004133_heterotaxia2.77262056
6MP0002928_abnormal_bile_duct2.62722318
7MP0006072_abnormal_retinal_apoptosis2.50624327
8MP0005448_abnormal_energy_balance2.23951310
9MP0005408_hypopigmentation2.22308057
10MP0002751_abnormal_autonomic_nervous2.21194007
11MP0001270_distended_abdomen2.03638631
12MP0005084_abnormal_gallbladder_morpholo12.5622489
13MP0004272_abnormal_basement_membrane1.90302228
14MP0003329_amyloid_beta_deposits1.89366305
15MP0005379_endocrine/exocrine_gland_phen1.75227045
16MP0005165_increased_susceptibility_to1.58147903
17MP0005220_abnormal_exocrine_pancreas1.55505112
18MP0003943_abnormal_hepatobiliary_system1.54473203
19MP0009764_decreased_sensitivity_to1.50026101
20MP0001529_abnormal_vocalization1.49641294
21MP0003718_maternal_effect1.47495836
22MP0000604_amyloidosis1.20677991
23MP0001905_abnormal_dopamine_level1.19615262
24MP0001958_emphysema1.16428824
25MP0005646_abnormal_pituitary_gland1.12593814
26MP0008875_abnormal_xenobiotic_pharmacok1.09307469
27MP0002909_abnormal_adrenal_gland1.07005084
28MP0002572_abnormal_emotion/affect_behav1.04487610
29MP0001800_abnormal_humoral_immune0.98148198
30MP0000470_abnormal_stomach_morphology0.97844720
31MP0001944_abnormal_pancreas_morphology0.95996759
32MP0003638_abnormal_response/metabolism_0.94541629
33MP0008469_abnormal_protein_level0.94275906
34MP0000465_gastrointestinal_hemorrhage0.92016945
35MP0008569_lethality_at_weaning0.90237661
36MP0001790_abnormal_immune_system0.88567808
37MP0005387_immune_system_phenotype0.88567808
38MP0003121_genomic_imprinting0.87667207
39MP0002405_respiratory_system_inflammati0.84997417
40MP0002693_abnormal_pancreas_physiology0.84138013
41MP0000371_diluted_coat_color0.83693837
42MP0001986_abnormal_taste_sensitivity0.83044260
43MP0004019_abnormal_vitamin_homeostasis0.81880357
44MP0005253_abnormal_eye_physiology0.78198498
45MP0003866_abnormal_defecation0.75517750
46MP0001915_intracranial_hemorrhage0.73710300
47MP0000609_abnormal_liver_physiology0.71197493
48MP0001533_abnormal_skeleton_physiology0.69797370
49MP0000703_abnormal_thymus_morphology0.67847213
50MP0005164_abnormal_response_to0.66382087
51MP0002078_abnormal_glucose_homeostasis0.65106319
52MP0002136_abnormal_kidney_physiology0.64371765
53MP0001835_abnormal_antigen_presentation0.61952263
54MP0002822_catalepsy0.61601054
55MP0003953_abnormal_hormone_level0.60555404
56MP0001845_abnormal_inflammatory_respons0.60478637
57MP0002098_abnormal_vibrissa_morphology0.58714702
58MP0002998_abnormal_bone_remodeling0.56862956
59MP0004947_skin_inflammation0.55868301
60MP0005551_abnormal_eye_electrophysiolog0.53536627
61MP0005671_abnormal_response_to0.52792554
62MP0002722_abnormal_immune_system0.52178276
63MP0001851_eye_inflammation0.49550914
64MP0002452_abnormal_antigen_presenting0.49168371
65MP0009642_abnormal_blood_homeostasis0.48648879
66MP0005000_abnormal_immune_tolerance0.48262484
67MP0002723_abnormal_immune_serum0.47306270
68MP0001501_abnormal_sleep_pattern0.45778844
69MP0002420_abnormal_adaptive_immunity0.45611552
70MP0001299_abnormal_eye_distance/0.45292208
71MP0002429_abnormal_blood_cell0.45224992
72MP0003195_calcinosis0.44940901
73MP0001819_abnormal_immune_cell0.44752060
74MP0002419_abnormal_innate_immunity0.43850341
75MP0000716_abnormal_immune_system0.41820472
76MP0002736_abnormal_nociception_after0.41389877
77MP0000920_abnormal_myelination0.41205889
78MP0009785_altered_susceptibility_to0.39532776
79MP0005645_abnormal_hypothalamus_physiol0.39234185
80MP0002102_abnormal_ear_morphology0.38811594
81MP0002735_abnormal_chemical_nociception0.37739645
82MP0002398_abnormal_bone_marrow0.37446588
83MP0002229_neurodegeneration0.37082882
84MP0005636_abnormal_mineral_homeostasis0.37055549
85MP0005395_other_phenotype0.36291114
86MP0000477_abnormal_intestine_morphology0.36112766
87MP0000598_abnormal_liver_morphology0.36025519
88MP0003436_decreased_susceptibility_to0.35342277
89MP0005334_abnormal_fat_pad0.34862857
90MP0002882_abnormal_neuron_morphology0.34401768
91MP0009931_abnormal_skin_appearance0.34128659
92MP0005390_skeleton_phenotype0.33674442
93MP0004484_altered_response_of0.33002156
94MP0000689_abnormal_spleen_morphology0.31614495
95MP0001968_abnormal_touch/_nociception0.30925809
96MP0002837_dystrophic_cardiac_calcinosis0.29612027
97MP0005319_abnormal_enzyme/_coenzyme0.29054452
98MP0005423_abnormal_somatic_nervous0.28712198
99MP0005365_abnormal_bile_salt0.28404619
100MP0002066_abnormal_motor_capabilities/c0.28082102

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.89532402
2Abnormality of dental color (HP:0011073)8.38518309
3Abnormality of renal resorption (HP:0011038)8.27465199
4Polyuria (HP:0000103)7.55436579
5Osteomalacia (HP:0002749)7.39450797
6Abnormality of the dental pulp (HP:0006479)7.21318351
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.64935533
8Abnormal urine output (HP:0012590)6.43971052
9Abnormality of renal excretion (HP:0011036)5.59858272
10Round ear (HP:0100830)5.44193399
11Chronic bronchitis (HP:0004469)4.76863666
12Autoimmune thrombocytopenia (HP:0001973)4.55740843
13Volvulus (HP:0002580)4.27472586
14IgM deficiency (HP:0002850)4.27446229
15Molar tooth sign on MRI (HP:0002419)4.11656109
16Abnormality of midbrain morphology (HP:0002418)4.11656109
17Toxemia of pregnancy (HP:0100603)4.05352215
18Lip pit (HP:0100267)3.80977981
19Nephrocalcinosis (HP:0000121)3.71893946
20Esophageal varix (HP:0002040)3.65155297
21Tachypnea (HP:0002789)3.33292648
22Abnormal respiratory motile cilium physiology (HP:0012261)3.31589748
23Depressed nasal tip (HP:0000437)3.26425750
24Rhinitis (HP:0012384)3.25542902
25Panhypogammaglobulinemia (HP:0003139)3.25469376
26Lipoatrophy (HP:0100578)3.24255973
27Large earlobe (HP:0009748)3.18992872
28Drooling (HP:0002307)3.13119587
29Hyperphosphaturia (HP:0003109)3.12600423
30Intestinal fistula (HP:0100819)3.02076648
31Nephronophthisis (HP:0000090)3.01443039
32Sparse lateral eyebrow (HP:0005338)2.99621335
33Excessive salivation (HP:0003781)2.98850766
34Recurrent cutaneous fungal infections (HP:0011370)2.89737792
35Chronic mucocutaneous candidiasis (HP:0002728)2.89737792
36Hypoparathyroidism (HP:0000829)2.87463260
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.86267107
38Ureteral stenosis (HP:0000071)2.71544723
39Thick eyebrow (HP:0000574)2.68421143
40Personality changes (HP:0000751)2.62059132
41Abnormality of urine glucose concentration (HP:0011016)2.60761724
42Glycosuria (HP:0003076)2.60761724
43Abnormal urine phosphate concentration (HP:0012599)2.60505931
44Inability to walk (HP:0002540)2.49880730
45Ureteral obstruction (HP:0006000)2.49498279
46Hepatitis (HP:0012115)2.44783391
47Petechiae (HP:0000967)2.43979050
48Dilated cardiomyopathy (HP:0001644)2.39197053
49Abnormality of transition element cation homeostasis (HP:0011030)2.32949372
50Nephropathy (HP:0000112)2.32010390
51Gingival overgrowth (HP:0000212)2.28952533
52Abnormality of the renal medulla (HP:0100957)2.27004252
53Striae distensae (HP:0001065)2.22760259
54Short 5th finger (HP:0009237)2.17903009
55Agammaglobulinemia (HP:0004432)2.16208404
56Colitis (HP:0002583)2.15760304
57Hypercalciuria (HP:0002150)2.14606361
58Decreased muscle mass (HP:0003199)2.14193654
59Bronchitis (HP:0012387)2.14165395
60Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.07816614
61Recurrent otitis media (HP:0000403)2.05416819
62Sudden cardiac death (HP:0001645)2.05270893
63Overgrowth (HP:0001548)11.8640295
64Amelogenesis imperfecta (HP:0000705)11.3234204
65Abnormality of salivation (HP:0100755)1.97266761
66Abnormality of the fingertips (HP:0001211)1.94493023
67Renal tubular dysfunction (HP:0000124)1.93797645
68Chorioretinal coloboma (HP:0000567)1.91068204
69Periauricular skin pits (HP:0100277)1.87444332
70Preauricular pit (HP:0004467)1.87444332
71Prominent supraorbital ridges (HP:0000336)1.87195908
72Polyneuropathy (HP:0001271)1.85366785
73Delayed eruption of teeth (HP:0000684)1.84600463
74Chondrocalcinosis (HP:0000934)1.75931478
75Anal stenosis (HP:0002025)1.75243645
76Abnormality of Sharpey fibers (HP:0100685)1.72573966
77Stage 5 chronic kidney disease (HP:0003774)1.72312519
78Abnormality of small intestinal villus morphology (HP:0011472)1.66279811
79Villous atrophy (HP:0011473)1.66279811
80Ectropion (HP:0000656)1.66218066
81Ectopic kidney (HP:0000086)1.65391290
82Small hand (HP:0200055)1.64207818
83Encephalitis (HP:0002383)1.62333020
84Preauricular skin tag (HP:0000384)1.61858280
85Oculomotor apraxia (HP:0000657)1.59455781
86Bronchiectasis (HP:0002110)1.58173801
87Torticollis (HP:0000473)1.56076217
88Palmoplantar keratoderma (HP:0000982)1.55187205
89Truncal ataxia (HP:0002078)1.54743863
90Prenatal maternal abnormality (HP:0002686)1.42352232
91Limited elbow extension (HP:0001377)1.41996030
92Delayed gross motor development (HP:0002194)1.41114761
93Highly arched eyebrow (HP:0002553)1.40656704
94Blepharitis (HP:0000498)1.40121503
95Inflammation of the large intestine (HP:0002037)1.39286270
96Abnormality of T cell physiology (HP:0011840)1.36053070
97Severe muscular hypotonia (HP:0006829)1.35207574
98Skin tags (HP:0010609)1.29897006
99Autoimmune hemolytic anemia (HP:0001890)1.29645132
100Viral hepatitis (HP:0006562)1.28108484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.63209833
2STK34.02849701
3BLK4.01450962
4RIPK42.90410529
5NTRK213.9601268
6CDC42BPA1.94785267
7BMPR21.92162258
8HIPK21.13280998
9TXK1.03405367
10MAP4K21.02892304
11TAOK30.95084478
12FGFR10.86790905
13ROCK20.72102724
14GRK10.70196682
15SYK0.69899598
16WNK30.68832923
17PRKCQ0.63543921
18INSRR0.62955062
19OBSCN0.62041241
20ADRBK20.61308323
21SRC0.59872035
22GRK70.57832559
23WNK40.57329053
24SRPK10.55917734
25PIK3CG0.55865322
26PRKAA10.53458548
27ROCK10.53240850
28OXSR10.52956722
29TLK10.52834616
30MUSK0.49813159
31ABL10.45038331
32MAP2K60.44899462
33PRKACG0.44536280
34TIE10.44142584
35PRKACA0.40269393
36PRKACB0.39842301
37CAMK2A0.39092551
38NEK10.38217990
39PHKG10.35425471
40PHKG20.35425471
41ZAK0.33342249
42MAPK150.32887724
43KIT0.32075416
44BCKDK0.30667157
45ERBB40.28730799
46MAP2K70.28675924
47PLK10.28172432
48LYN0.27644938
49EPHA40.26826775
50STK390.26585821
51PRKCA0.25912385
52MARK10.24904662
53MAP3K40.24659057
54KDR0.24443382
55MATK0.23996932
56FRK0.23136855
57IRAK40.22566470
58ITK0.21680561
59PRKCB0.21607790
60CSNK1A10.21071161
61MAPK140.20760862
62LCK0.19325590
63FYN0.18727087
64GSK3B0.18617648
65RPS6KA30.18506677
66EPHA30.17584100
67TNK20.16151626
68PRKCG0.15279567
69VRK10.15254429
70GRK50.13908002
71PRKCD0.12679319
72CHUK0.12541593
73PKN10.12124249
74PINK10.12116613
75LMTK20.11958912
76IGF1R0.11858246
77MAPK90.11746382
78ACVR1B0.11186999
79TEC0.10890128
80CDK10.10745531
81IKBKE0.10622919
82CASK0.10562319
83MAPK130.10374791
84BTK0.10188216
85RPS6KA50.09971353
86CAMK2G0.09680344
87PRKG10.09466935
88PRKCE0.09166302
89ADRBK10.09049637
90EGFR0.08474884
91TGFBR20.08241317
92CAMK2D0.07920047
93PLK40.07647906
94CSF1R0.07272093
95PRKDC0.07002457
96MYLK0.06532469
97PRKG20.06445621
98CDK30.06362756
99EPHA20.06002068
100CAMK2B0.05921259

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.28740981
2Sulfur metabolism_Homo sapiens_hsa009203.90023787
3Sulfur relay system_Homo sapiens_hsa041223.74348697
4Ovarian steroidogenesis_Homo sapiens_hsa049133.31390420
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26574029
6Linoleic acid metabolism_Homo sapiens_hsa005913.00938656
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.68957247
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.60096353
9Collecting duct acid secretion_Homo sapiens_hsa049662.58481210
10Vibrio cholerae infection_Homo sapiens_hsa051102.38293712
11Bile secretion_Homo sapiens_hsa049762.28020980
12Pancreatic secretion_Homo sapiens_hsa049722.18841217
13Fat digestion and absorption_Homo sapiens_hsa049752.18358650
14Salivary secretion_Homo sapiens_hsa049702.17128302
15Thyroid hormone synthesis_Homo sapiens_hsa049182.12562733
16Synaptic vesicle cycle_Homo sapiens_hsa047212.05547306
17Gastric acid secretion_Homo sapiens_hsa049712.04024484
18Cocaine addiction_Homo sapiens_hsa050301.99402804
19Circadian entrainment_Homo sapiens_hsa047131.86984261
20Insulin secretion_Homo sapiens_hsa049111.84384037
21Ether lipid metabolism_Homo sapiens_hsa005651.75505961
22Taste transduction_Homo sapiens_hsa047421.74809954
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74175029
24Glutamatergic synapse_Homo sapiens_hsa047241.71310461
25GABAergic synapse_Homo sapiens_hsa047271.71294480
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.69816331
27Morphine addiction_Homo sapiens_hsa050321.69601876
28Dilated cardiomyopathy_Homo sapiens_hsa054141.55195336
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47159027
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46419269
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.44526054
32Amphetamine addiction_Homo sapiens_hsa050311.43161417
33Gap junction_Homo sapiens_hsa045401.39446695
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39219623
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35806450
36Arachidonic acid metabolism_Homo sapiens_hsa005901.34165407
37Melanogenesis_Homo sapiens_hsa049161.20600900
38GnRH signaling pathway_Homo sapiens_hsa049121.20500089
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07386658
40Cholinergic synapse_Homo sapiens_hsa047251.06851281
41Oxytocin signaling pathway_Homo sapiens_hsa049211.05528362
42Platelet activation_Homo sapiens_hsa046111.05105130
43Calcium signaling pathway_Homo sapiens_hsa040201.02854621
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02082532
45Circadian rhythm_Homo sapiens_hsa047100.97839707
46Estrogen signaling pathway_Homo sapiens_hsa049150.89769760
47Rheumatoid arthritis_Homo sapiens_hsa053230.87657202
48Pyruvate metabolism_Homo sapiens_hsa006200.82478851
49Caffeine metabolism_Homo sapiens_hsa002320.78928791
50Dorso-ventral axis formation_Homo sapiens_hsa043200.78312015
51Serotonergic synapse_Homo sapiens_hsa047260.77459716
52RNA degradation_Homo sapiens_hsa030180.72494092
53Parkinsons disease_Homo sapiens_hsa050120.69003894
54Chemokine signaling pathway_Homo sapiens_hsa040620.68920829
55Oocyte meiosis_Homo sapiens_hsa041140.66108858
56Primary immunodeficiency_Homo sapiens_hsa053400.62857911
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58535046
58Oxidative phosphorylation_Homo sapiens_hsa001900.55594759
59ECM-receptor interaction_Homo sapiens_hsa045120.55404669
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43353560
61Asthma_Homo sapiens_hsa053100.41761571
62cAMP signaling pathway_Homo sapiens_hsa040240.40859685
63Alcoholism_Homo sapiens_hsa050340.38214342
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.37380970
65Dopaminergic synapse_Homo sapiens_hsa047280.37366271
66Autoimmune thyroid disease_Homo sapiens_hsa053200.35742866
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35642372
68Purine metabolism_Homo sapiens_hsa002300.34478763
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.32827926
70Staphylococcus aureus infection_Homo sapiens_hsa051500.31768572
71Type I diabetes mellitus_Homo sapiens_hsa049400.30589622
72Allograft rejection_Homo sapiens_hsa053300.30563013
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.30045931
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29013766
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26648885
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.26584158
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26094082
78Retinol metabolism_Homo sapiens_hsa008300.22849513
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.17484992
80Graft-versus-host disease_Homo sapiens_hsa053320.17061757
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16071201
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.15376735
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.15196093
84Hematopoietic cell lineage_Homo sapiens_hsa046400.14692739
85Chemical carcinogenesis_Homo sapiens_hsa052040.13962031
86Nicotine addiction_Homo sapiens_hsa050330.13064813
87Tuberculosis_Homo sapiens_hsa051520.12902053
88Systemic lupus erythematosus_Homo sapiens_hsa053220.12264527
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12119685
90Prion diseases_Homo sapiens_hsa050200.11357675
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11202509
92African trypanosomiasis_Homo sapiens_hsa051430.11021306
93Rap1 signaling pathway_Homo sapiens_hsa040150.10397252
94Phagosome_Homo sapiens_hsa041450.09727034
95Leishmaniasis_Homo sapiens_hsa051400.09651053
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.09608796
97Antigen processing and presentation_Homo sapiens_hsa046120.08730416
98Hedgehog signaling pathway_Homo sapiens_hsa043400.07420693
99Ras signaling pathway_Homo sapiens_hsa040140.06499991
100HTLV-I infection_Homo sapiens_hsa051660.06154816

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