VDAC1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)7.97967016
2keratinocyte development (GO:0003334)7.75126566
3positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.74606880
4regulation of autophagic vacuole assembly (GO:2000785)4.54858847
5behavioral response to nicotine (GO:0035095)4.43920316
6pyrimidine nucleobase catabolic process (GO:0006208)4.40831724
7positive regulation of prostaglandin secretion (GO:0032308)4.39746901
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.29784967
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.29784967
10proteasome assembly (GO:0043248)4.17205882
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.14477770
12NADH dehydrogenase complex assembly (GO:0010257)4.14477770
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14477770
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05291311
15neurotransmitter-gated ion channel clustering (GO:0072578)3.88412067
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86968423
17ATP synthesis coupled proton transport (GO:0015986)3.86968423
18protein-cofactor linkage (GO:0018065)3.85613676
19regulation of vacuole organization (GO:0044088)3.81985065
20protein complex biogenesis (GO:0070271)3.73715518
21nucleobase catabolic process (GO:0046113)3.69803865
22mitochondrial respiratory chain complex assembly (GO:0033108)3.55694098
23ear development (GO:0043583)3.50595442
24negative regulation of gluconeogenesis (GO:0045721)3.48846693
25regulation of prostaglandin secretion (GO:0032306)3.48507612
26regulation of synapse structural plasticity (GO:0051823)3.46813202
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46000922
28presynaptic membrane assembly (GO:0097105)3.42537053
29proline transport (GO:0015824)3.42452650
30sequestering of actin monomers (GO:0042989)3.40942704
31protein polyglutamylation (GO:0018095)3.39420242
32positive regulation of mitochondrial fission (GO:0090141)3.35971331
33centrosome localization (GO:0051642)3.33929011
34seminiferous tubule development (GO:0072520)3.28051091
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24454394
36transepithelial transport (GO:0070633)3.24298854
37serotonin receptor signaling pathway (GO:0007210)3.21337919
38regulation of development, heterochronic (GO:0040034)3.17509134
39olfactory bulb development (GO:0021772)3.17187812
40negative regulation of protein acetylation (GO:1901984)3.14859130
41postsynaptic membrane organization (GO:0001941)3.14552019
42protein prenylation (GO:0018342)3.12902108
43prenylation (GO:0097354)3.12902108
44intraciliary transport (GO:0042073)3.10613702
45positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.09230920
46vocalization behavior (GO:0071625)3.04597733
47mannosylation (GO:0097502)3.04090057
48histone H2A acetylation (GO:0043968)2.98798170
49SMAD protein complex assembly (GO:0007183)2.98497905
50chaperone-mediated protein transport (GO:0072321)2.94951648
51presynaptic membrane organization (GO:0097090)2.92910553
52piRNA metabolic process (GO:0034587)2.92483555
53regulation of cilium movement (GO:0003352)2.91810690
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91024189
55DNA damage response, detection of DNA damage (GO:0042769)2.90762986
56regulation of timing of cell differentiation (GO:0048505)2.88524829
57autophagic vacuole fusion (GO:0000046)2.87699329
58positive regulation of amino acid transport (GO:0051957)2.85978057
59preassembly of GPI anchor in ER membrane (GO:0016254)2.84425968
60protein deneddylation (GO:0000338)2.82426029
61respiratory electron transport chain (GO:0022904)2.81826904
62positive regulation of insulin receptor signaling pathway (GO:0046628)2.81714530
63nonmotile primary cilium assembly (GO:0035058)2.81389835
64electron transport chain (GO:0022900)2.80991297
65positive regulation of organic acid transport (GO:0032892)2.80767263
66positive regulation of fatty acid transport (GO:2000193)2.77159790
67organelle membrane fusion (GO:0090174)2.76202929
68regulation of rhodopsin mediated signaling pathway (GO:0022400)2.76070903
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75818294
70establishment of protein localization to mitochondrial membrane (GO:0090151)2.74625563
71respiratory chain complex IV assembly (GO:0008535)2.73484305
72cullin deneddylation (GO:0010388)2.69813713
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68746608
74basic amino acid transport (GO:0015802)2.68149285
75activated T cell proliferation (GO:0050798)2.67144793
76positive regulation of icosanoid secretion (GO:0032305)2.66147230
77spinal cord development (GO:0021510)2.61224915
78positive regulation of protein homooligomerization (GO:0032464)2.61073797
79positive regulation of guanylate cyclase activity (GO:0031284)2.59008382
80estrogen biosynthetic process (GO:0006703)2.57961869
81histone H3-K9 methylation (GO:0051567)2.57599747
82rhodopsin mediated signaling pathway (GO:0016056)2.57063431
83GPI anchor biosynthetic process (GO:0006506)2.54079327
84myoblast migration (GO:0051451)2.53737083
85peptidyl-histidine modification (GO:0018202)2.52362305
86GPI anchor metabolic process (GO:0006505)2.49957826
87iron-sulfur cluster assembly (GO:0016226)2.47207852
88metallo-sulfur cluster assembly (GO:0031163)2.47207852
89termination of RNA polymerase III transcription (GO:0006386)2.46631677
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.46631677
91regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.45376952
92negative regulation of astrocyte differentiation (GO:0048712)2.45104240
93adenosine metabolic process (GO:0046085)2.43987066
94positive regulation of neurological system process (GO:0031646)2.42977109
95cilium organization (GO:0044782)2.42230556
96cilium assembly (GO:0042384)2.42038587
97sphingoid metabolic process (GO:0046519)2.41056878
98positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.40620931
99dopamine transport (GO:0015872)2.38762359
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37681183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.59543921
2ZNF274_21170338_ChIP-Seq_K562_Hela3.68875977
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57416243
4VDR_22108803_ChIP-Seq_LS180_Human3.33373047
5TAF15_26573619_Chip-Seq_HEK293_Human2.94829298
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.82856756
7IGF1R_20145208_ChIP-Seq_DFB_Human2.71436433
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70926120
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.64632913
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37181869
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31256785
12EZH2_22144423_ChIP-Seq_EOC_Human2.21337159
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.19575120
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.15713593
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09355651
16EWS_26573619_Chip-Seq_HEK293_Human2.08910148
17P300_19829295_ChIP-Seq_ESCs_Human2.01683760
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91148737
19GBX2_23144817_ChIP-Seq_PC3_Human1.88489243
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86331684
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85883265
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84757795
23GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.83896663
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83355584
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.82919315
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80574445
27VDR_23849224_ChIP-Seq_CD4+_Human1.78533730
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.77211752
29ER_23166858_ChIP-Seq_MCF-7_Human1.71865727
30ELK1_19687146_ChIP-ChIP_HELA_Human1.71644917
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.70975375
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67132033
33IRF1_19129219_ChIP-ChIP_H3396_Human1.66906291
34FUS_26573619_Chip-Seq_HEK293_Human1.62099908
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61303696
36BCAT_22108803_ChIP-Seq_LS180_Human1.60462340
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55807763
38SMAD4_21799915_ChIP-Seq_A2780_Human1.52928953
39TCF4_22108803_ChIP-Seq_LS180_Human1.51973871
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51690256
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49059299
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46687959
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46379095
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.46195378
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41441931
46AR_25329375_ChIP-Seq_VCAP_Human1.40152139
47RNF2_27304074_Chip-Seq_NSC_Mouse1.35284346
48TP53_22573176_ChIP-Seq_HFKS_Human1.33769714
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31412500
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.29698396
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28267000
52STAT3_18555785_Chip-Seq_ESCs_Mouse1.28015180
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26389883
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.25801331
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23506041
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23431798
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.21705775
58P53_22387025_ChIP-Seq_ESCs_Mouse1.20355645
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18665996
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18387571
61RUNX2_22187159_ChIP-Seq_PCA_Human1.17330031
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16178973
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.14788331
64TCF4_23295773_ChIP-Seq_U87_Human1.14487915
65FOXP3_21729870_ChIP-Seq_TREG_Human1.14027942
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13735132
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.13175956
68STAT3_23295773_ChIP-Seq_U87_Human1.13073193
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12723349
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12531909
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.11590254
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11558398
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11097405
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10990679
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.10559037
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10275665
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10004373
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09982564
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.09756652
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08750495
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07915497
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06214579
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.05606917
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.05083353
85CDX2_22108803_ChIP-Seq_LS180_Human1.04030373
86NANOG_19829295_ChIP-Seq_ESCs_Human1.03960542
87SOX2_19829295_ChIP-Seq_ESCs_Human1.03960542
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.03837791
89P300_18555785_Chip-Seq_ESCs_Mouse1.02360947
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02287130
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01355177
92MYC_19829295_ChIP-Seq_ESCs_Human1.01177118
93MYC_18940864_ChIP-ChIP_HL60_Human1.00438342
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00166115
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.99273002
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99247764
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97761711
98ZFX_18555785_Chip-Seq_ESCs_Mouse0.96747052
99ELF5_23300383_ChIP-Seq_T47D_Human0.96687797
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96021944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.88532529
2MP0003880_abnormal_central_pattern3.85545155
3MP0002102_abnormal_ear_morphology3.53275746
4MP0000372_irregular_coat_pigmentation2.76372282
5MP0004142_abnormal_muscle_tone2.73457694
6MP0002736_abnormal_nociception_after2.60172988
7MP0002837_dystrophic_cardiac_calcinosis2.60159110
8MP0006276_abnormal_autonomic_nervous2.53675455
9MP0008789_abnormal_olfactory_epithelium2.33642579
10MP0005551_abnormal_eye_electrophysiolog2.30944054
11MP0006035_abnormal_mitochondrial_morpho2.30154281
12MP0005646_abnormal_pituitary_gland2.27567891
13MP0001968_abnormal_touch/_nociception2.24231340
14MP0000049_abnormal_middle_ear2.21012390
15MP0005394_taste/olfaction_phenotype2.11707822
16MP0005499_abnormal_olfactory_system2.11707822
17MP0008875_abnormal_xenobiotic_pharmacok1.91725259
18MP0001529_abnormal_vocalization1.90366808
19MP0009379_abnormal_foot_pigmentation1.86262720
20MP0004147_increased_porphyrin_level1.82298135
21MP0010386_abnormal_urinary_bladder1.81238826
22MP0000427_abnormal_hair_cycle1.77461520
23MP0001984_abnormal_olfaction1.76313828
24MP0008775_abnormal_heart_ventricle1.65570030
25MP0005084_abnormal_gallbladder_morpholo1.57823013
26MP0006292_abnormal_olfactory_placode1.57657008
27MP0002272_abnormal_nervous_system1.57285502
28MP0001905_abnormal_dopamine_level1.53125283
29MP0001485_abnormal_pinna_reflex1.46168279
30MP0008872_abnormal_physiological_respon1.44051554
31MP0008058_abnormal_DNA_repair1.43463214
32MP0001764_abnormal_homeostasis1.42846009
33MP0002876_abnormal_thyroid_physiology1.41116884
34MP0000778_abnormal_nervous_system1.40699792
35MP0002139_abnormal_hepatobiliary_system1.38894495
36MP0003806_abnormal_nucleotide_metabolis1.38770919
37MP0009046_muscle_twitch1.38124629
38MP0004924_abnormal_behavior1.37208155
39MP0005386_behavior/neurological_phenoty1.37208155
40MP0000639_abnormal_adrenal_gland1.35032763
41MP0002638_abnormal_pupillary_reflex1.33532914
42MP0004859_abnormal_synaptic_plasticity1.33508793
43MP0009745_abnormal_behavioral_response1.30223858
44MP0002557_abnormal_social/conspecific_i1.29420566
45MP0001919_abnormal_reproductive_system1.27793565
46MP0003937_abnormal_limbs/digits/tail_de1.26224567
47MP0003787_abnormal_imprinting1.25941394
48MP0005647_abnormal_sex_gland1.24991763
49MP0004885_abnormal_endolymph1.24883295
50MP0001486_abnormal_startle_reflex1.24545786
51MP0000647_abnormal_sebaceous_gland1.20399012
52MP0003718_maternal_effect1.17611425
53MP0004133_heterotaxia1.16903610
54MP0001970_abnormal_pain_threshold1.15890752
55MP0005389_reproductive_system_phenotype1.14806661
56MP0002163_abnormal_gland_morphology1.14546411
57MP0002229_neurodegeneration1.14433043
58MP0005645_abnormal_hypothalamus_physiol1.14284736
59MP0002734_abnormal_mechanical_nocicepti1.13503445
60MP0001502_abnormal_circadian_rhythm1.12460853
61MP0003252_abnormal_bile_duct1.11621781
62MP0003941_abnormal_skin_development1.08860194
63MP0006072_abnormal_retinal_apoptosis1.07997349
64MP0002233_abnormal_nose_morphology1.06970980
65MP0005423_abnormal_somatic_nervous1.06275741
66MP0002210_abnormal_sex_determination1.06008723
67MP0006036_abnormal_mitochondrial_physio1.04970476
68MP0002733_abnormal_thermal_nociception1.02874286
69MP0001963_abnormal_hearing_physiology1.01330345
70MP0005253_abnormal_eye_physiology0.98246218
71MP0003936_abnormal_reproductive_system0.95384211
72MP0003121_genomic_imprinting0.94990934
73MP0002752_abnormal_somatic_nervous0.94234012
74MP0003635_abnormal_synaptic_transmissio0.93484284
75MP0002572_abnormal_emotion/affect_behav0.93132442
76MP0000653_abnormal_sex_gland0.91355559
77MP0000026_abnormal_inner_ear0.91302815
78MP0003186_abnormal_redox_activity0.90435109
79MP0003938_abnormal_ear_development0.89964768
80MP0003698_abnormal_male_reproductive0.89700557
81MP0001145_abnormal_male_reproductive0.89663859
82MP0005195_abnormal_posterior_eye0.89341215
83MP0010094_abnormal_chromosome_stability0.88273833
84MP0001756_abnormal_urination0.87718216
85MP0000358_abnormal_cell_content/0.87655964
86MP0002064_seizures0.86227225
87MP0005332_abnormal_amino_acid0.85575220
88MP0004484_altered_response_of0.85225879
89MP0001929_abnormal_gametogenesis0.83320091
90MP0005257_abnormal_intraocular_pressure0.82874300
91MP0002882_abnormal_neuron_morphology0.82279210
92MP0005410_abnormal_fertilization0.80907311
93MP0001879_abnormal_lymphatic_vessel0.80542407
94MP0002063_abnormal_learning/memory/cond0.80359381
95MP0000631_abnormal_neuroendocrine_gland0.80070123
96MP0002160_abnormal_reproductive_system0.78937400
97MP0004742_abnormal_vestibular_system0.78550591
98MP0005187_abnormal_penis_morphology0.78004702
99MP0003195_calcinosis0.76010074
100MP0009765_abnormal_xenobiotic_induced0.74348178

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.44984670
2Hyperalaninemia (HP:0003348)4.44984670
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.44984670
4Acute necrotizing encephalopathy (HP:0006965)4.08885123
5Acute encephalopathy (HP:0006846)3.81652601
6Type II lissencephaly (HP:0007260)3.67138394
7Abnormal mitochondria in muscle tissue (HP:0008316)3.58680895
8Short tibia (HP:0005736)3.55184863
9Aplasia/Hypoplasia of the tibia (HP:0005772)3.46887574
10Progressive macrocephaly (HP:0004481)3.42269876
11Tubulointerstitial nephritis (HP:0001970)3.35901468
12Lissencephaly (HP:0001339)3.32360675
13Mitochondrial inheritance (HP:0001427)3.26857365
14Increased CSF lactate (HP:0002490)3.25194890
15Infantile muscular hypotonia (HP:0008947)3.05607974
16Cerebellar dysplasia (HP:0007033)3.04381815
17CNS hypomyelination (HP:0003429)2.90958951
18Hypoplasia of the pons (HP:0012110)2.81954047
19Abnormality of the pons (HP:0007361)2.76914396
20Nephronophthisis (HP:0000090)2.73929858
21Abnormality of midbrain morphology (HP:0002418)2.64732304
22Molar tooth sign on MRI (HP:0002419)2.64732304
23Increased serum pyruvate (HP:0003542)2.64442970
24Pendular nystagmus (HP:0012043)2.62845523
25Aplasia/Hypoplasia involving the musculature (HP:0001460)2.54637342
26Cerebral edema (HP:0002181)2.53250535
27Hyperglycinuria (HP:0003108)2.53102856
28Tubular atrophy (HP:0000092)2.50934968
29Abnormal number of erythroid precursors (HP:0012131)2.50285752
30Hypothermia (HP:0002045)2.49399559
31Methylmalonic acidemia (HP:0002912)2.49115704
32Fibular hypoplasia (HP:0003038)2.43148678
33Methylmalonic aciduria (HP:0012120)2.43039930
34Optic nerve hypoplasia (HP:0000609)2.40794166
35Lipid accumulation in hepatocytes (HP:0006561)2.40572042
36Medial flaring of the eyebrow (HP:0010747)2.38791205
37Febrile seizures (HP:0002373)2.36938381
38Increased hepatocellular lipid droplets (HP:0006565)2.35368902
39Congenital primary aphakia (HP:0007707)2.30528848
40Focal motor seizures (HP:0011153)2.27034800
41Abnormality of the renal medulla (HP:0100957)2.26457581
42Hepatocellular necrosis (HP:0001404)2.24898071
43Gait imbalance (HP:0002141)2.24573924
44Hyperglycinemia (HP:0002154)2.23285731
45Poikilocytosis (HP:0004447)2.22368950
46Aplasia/Hypoplasia of the fibula (HP:0006492)2.21951204
47Patellar aplasia (HP:0006443)2.19449273
48Renal Fanconi syndrome (HP:0001994)2.19078015
49Pancreatic cysts (HP:0001737)2.17891109
50Aplasia/Hypoplasia of the patella (HP:0006498)2.17106174
51Abnormality of serum amino acid levels (HP:0003112)2.15422533
52Retinal dysplasia (HP:0007973)2.15264694
53Aplasia of the musculature (HP:0100854)2.14855100
54Delayed CNS myelination (HP:0002188)2.14725010
55Parakeratosis (HP:0001036)2.13227328
56Hyperventilation (HP:0002883)2.12996315
57Mesomelia (HP:0003027)2.10984139
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09601879
59Polyphagia (HP:0002591)2.09550266
60Congenital, generalized hypertrichosis (HP:0004540)2.07928508
61Sensorimotor neuropathy (HP:0007141)2.07486549
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06618813
63Pancreatic fibrosis (HP:0100732)2.06567574
64Colon cancer (HP:0003003)2.06501659
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06022044
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06022044
67Abnormality of glycolysis (HP:0004366)2.05659644
68Lactic acidosis (HP:0003128)2.05440590
69Brushfield spots (HP:0001088)2.04925549
70Abnormal drinking behavior (HP:0030082)2.01096718
71Polydipsia (HP:0001959)2.01096718
72Polymicrogyria (HP:0002126)2.00736312
73Gonadotropin excess (HP:0000837)1.99999713
74Abnormality of cells of the erythroid lineage (HP:0012130)1.97808942
75Sclerocornea (HP:0000647)1.97415213
76True hermaphroditism (HP:0010459)1.97238141
77Lethargy (HP:0001254)1.94340432
78Abnormality of the renal cortex (HP:0011035)1.94318964
79Abnormality of serine family amino acid metabolism (HP:0010894)1.94200806
80Abnormality of glycine metabolism (HP:0010895)1.94200806
81Optic disc pallor (HP:0000543)1.92167234
82Vaginal atresia (HP:0000148)1.91310359
83Stomach cancer (HP:0012126)1.89779888
84Respiratory failure (HP:0002878)1.89351221
85Nephrogenic diabetes insipidus (HP:0009806)1.88359207
86Genital tract atresia (HP:0001827)1.86560419
87Hepatic necrosis (HP:0002605)1.86095114
88Increased serum lactate (HP:0002151)1.85010969
89Autoamputation (HP:0001218)1.81053800
90Poor suck (HP:0002033)1.81030976
91Hypomagnesemia (HP:0002917)1.78929056
92Severe visual impairment (HP:0001141)1.78820142
93Broad-based gait (HP:0002136)1.76687438
94X-linked dominant inheritance (HP:0001423)1.76598944
95Increased intramyocellular lipid droplets (HP:0012240)1.76146510
96Abnormality of the labia minora (HP:0012880)1.76048867
97Dyskinesia (HP:0100660)1.75615454
98Abnormality of urine glucose concentration (HP:0011016)1.74682404
99Glycosuria (HP:0003076)1.74682404
100Drooling (HP:0002307)1.73452149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.91725598
2MAP3K123.80455541
3FRK3.57444925
4ZAK3.33617845
5TRIM283.07133008
6LIMK12.58428130
7NME12.25471660
8NEK12.15107068
9MAP4K22.13002345
10NTRK32.09336021
11NUAK12.07261161
12SRPK11.95948845
13BCKDK1.95637055
14BMPR21.95003544
15MAP2K71.91761754
16ERBB31.80879468
17MST41.80098489
18MARK11.75730678
19DYRK21.70713724
20MAP3K41.65277030
21TESK11.65196506
22TLK11.63896653
23WNK31.62602810
24TNIK1.56219594
25PDK21.49746048
26MAP3K91.49464554
27BMPR1B1.46340577
28MAPK131.45089941
29YES11.44062349
30BCR1.34136584
31STK391.31506581
32TAOK31.27034088
33CSNK1G21.25694054
34GRK11.22314334
35PAK31.09899748
36TNK21.03449211
37WEE11.02752897
38OXSR11.00738837
39PAK61.00646563
40CSNK1G30.95773130
41PIM20.85891957
42EIF2AK30.84804355
43PINK10.84291912
44TAOK10.83105060
45CSNK1A1L0.82999214
46ADRBK20.82826507
47MYLK0.79900276
48CSNK1G10.74941620
49MINK10.73295021
50PRKCG0.70198498
51INSRR0.68228150
52PLK10.68214289
53PLK30.68164547
54RPS6KA40.65010491
55GRK50.64513666
56RPS6KA50.63680880
57ACVR1B0.62127049
58TAF10.61066902
59PIK3CA0.60290163
60KSR10.60264539
61PRKCI0.59401798
62SIK30.58597703
63CLK10.58121127
64FES0.56754651
65DYRK1B0.56469124
66VRK10.56440211
67KDR0.56423388
68TAOK20.56059107
69CSNK2A10.50964648
70VRK20.49607959
71ARAF0.48535420
72EPHB20.48392151
73CSNK1A10.47908023
74CHEK20.47907099
75CAMK2D0.46179430
76NEK60.45905766
77PTK2B0.45796213
78BRSK20.44984423
79PRKCE0.42657654
80CDK30.39989986
81ROCK10.39221377
82CAMK2A0.38235748
83FLT30.35204169
84WNK40.34608973
85LATS10.33995426
86MOS0.33846271
87ABL20.33585287
88PRKACA0.32659375
89ATM0.30275195
90PKN10.29599081
91PLK20.29534004
92TYRO30.29086132
93EPHA40.28308599
94TIE10.27407800
95PRKCZ0.26918852
96PRKCA0.26757138
97ATR0.26286982
98AURKB0.24772499
99MUSK0.24726167
100GSK3A0.24499764

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.66459923
2Protein export_Homo sapiens_hsa030603.14428118
3Parkinsons disease_Homo sapiens_hsa050123.01735124
4Proteasome_Homo sapiens_hsa030502.96009517
5Phototransduction_Homo sapiens_hsa047442.85720686
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78206764
7Huntingtons disease_Homo sapiens_hsa050162.51816159
8RNA polymerase_Homo sapiens_hsa030202.42568313
9Nicotine addiction_Homo sapiens_hsa050332.27812163
10Fanconi anemia pathway_Homo sapiens_hsa034602.20638420
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18648772
12Alzheimers disease_Homo sapiens_hsa050102.06151758
13Propanoate metabolism_Homo sapiens_hsa006402.02356928
14Homologous recombination_Homo sapiens_hsa034401.95945154
15Base excision repair_Homo sapiens_hsa034101.95555263
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90868980
17Butanoate metabolism_Homo sapiens_hsa006501.85633620
18RNA degradation_Homo sapiens_hsa030181.85584428
19Caffeine metabolism_Homo sapiens_hsa002321.79414170
20Mismatch repair_Homo sapiens_hsa034301.76325598
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70225960
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69717183
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69559761
24Nitrogen metabolism_Homo sapiens_hsa009101.54182204
25Ribosome_Homo sapiens_hsa030101.52998669
26Peroxisome_Homo sapiens_hsa041461.52225356
27Fatty acid elongation_Homo sapiens_hsa000621.52181085
28Basal transcription factors_Homo sapiens_hsa030221.42309438
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.38304638
30DNA replication_Homo sapiens_hsa030301.32974615
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30529431
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30214899
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26677756
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25844147
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25529106
36Spliceosome_Homo sapiens_hsa030401.21043415
37Pyrimidine metabolism_Homo sapiens_hsa002401.19713219
38Linoleic acid metabolism_Homo sapiens_hsa005911.19462338
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15570307
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10337529
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03612615
42Nucleotide excision repair_Homo sapiens_hsa034201.02765157
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02557828
44Steroid biosynthesis_Homo sapiens_hsa001001.02276528
45Taste transduction_Homo sapiens_hsa047421.02179720
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.99835924
47Fat digestion and absorption_Homo sapiens_hsa049750.97064029
48Cardiac muscle contraction_Homo sapiens_hsa042600.95522749
49Purine metabolism_Homo sapiens_hsa002300.93549415
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93271523
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.92583979
52Olfactory transduction_Homo sapiens_hsa047400.90458367
53Chemical carcinogenesis_Homo sapiens_hsa052040.89893222
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89197592
55One carbon pool by folate_Homo sapiens_hsa006700.85921320
56Metabolic pathways_Homo sapiens_hsa011000.79875883
57Sulfur metabolism_Homo sapiens_hsa009200.78716038
58Regulation of autophagy_Homo sapiens_hsa041400.74492488
59Morphine addiction_Homo sapiens_hsa050320.72824949
60Retinol metabolism_Homo sapiens_hsa008300.70826709
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70022218
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69437760
63Non-homologous end-joining_Homo sapiens_hsa034500.69039914
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68514217
65Tryptophan metabolism_Homo sapiens_hsa003800.68446299
66TGF-beta signaling pathway_Homo sapiens_hsa043500.66138409
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63747923
68RNA transport_Homo sapiens_hsa030130.63131800
69Collecting duct acid secretion_Homo sapiens_hsa049660.60853780
70Fatty acid degradation_Homo sapiens_hsa000710.59145540
71Folate biosynthesis_Homo sapiens_hsa007900.58264317
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57494073
73Cocaine addiction_Homo sapiens_hsa050300.57491365
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57303287
75Fatty acid metabolism_Homo sapiens_hsa012120.52920511
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51712822
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51415882
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50560811
79Circadian rhythm_Homo sapiens_hsa047100.49631869
80Glutathione metabolism_Homo sapiens_hsa004800.48825997
81Hedgehog signaling pathway_Homo sapiens_hsa043400.48760241
82GABAergic synapse_Homo sapiens_hsa047270.48334312
83Sphingolipid metabolism_Homo sapiens_hsa006000.48148843
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46669244
85Circadian entrainment_Homo sapiens_hsa047130.46606727
86Glutamatergic synapse_Homo sapiens_hsa047240.46493857
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43383021
88Axon guidance_Homo sapiens_hsa043600.42941668
89Vitamin B6 metabolism_Homo sapiens_hsa007500.41199703
90Arachidonic acid metabolism_Homo sapiens_hsa005900.40375497
91Ether lipid metabolism_Homo sapiens_hsa005650.40257981
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.36921496
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35827273
94beta-Alanine metabolism_Homo sapiens_hsa004100.35652846
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33474750
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32990969
97Pyruvate metabolism_Homo sapiens_hsa006200.31801502
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29170740
99Salivary secretion_Homo sapiens_hsa049700.28773614
100Serotonergic synapse_Homo sapiens_hsa047260.26485817

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