VDAC1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cytokine production involved in inflammatory response (GO:1900015)8.63921227
2negative regulation of thymocyte apoptotic process (GO:0070244)5.52985041
3positive regulation of transcription regulatory region DNA binding (GO:2000679)5.46220168
4cullin deneddylation (GO:0010388)5.39366878
5DNA double-strand break processing (GO:0000729)5.28973998
6DNA catabolic process, exonucleolytic (GO:0000738)5.22791236
7regulation of immunoglobulin secretion (GO:0051023)5.10939856
8protein deneddylation (GO:0000338)4.70703370
9DNA damage response, detection of DNA damage (GO:0042769)4.68206626
10positive regulation of T cell cytokine production (GO:0002726)4.63669364
11chaperone-mediated protein transport (GO:0072321)4.62380251
12positive regulation of osteoclast differentiation (GO:0045672)4.60377735
13membrane protein intracellular domain proteolysis (GO:0031293)4.44805406
14proteasome assembly (GO:0043248)4.32735781
15rRNA methylation (GO:0031167)4.27850351
16signal peptide processing (GO:0006465)4.27557122
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.25816677
18rRNA modification (GO:0000154)4.05434670
19regulation of cellular amino acid metabolic process (GO:0006521)4.02298449
20regulation of interleukin-6 biosynthetic process (GO:0045408)3.91657205
21peptidyl-arginine omega-N-methylation (GO:0035247)3.90209101
22pseudouridine synthesis (GO:0001522)3.87895734
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.83710416
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68607271
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55071041
26peptidyl-arginine N-methylation (GO:0035246)3.53248326
27peptidyl-arginine methylation (GO:0018216)3.53248326
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.44803250
29activated T cell proliferation (GO:0050798)3.40991237
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37076748
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37076748
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37076748
33folic acid-containing compound biosynthetic process (GO:0009396)3.35535185
34intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34843547
35signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34843547
36regulation of thymocyte apoptotic process (GO:0070243)3.34195111
37peroxisome fission (GO:0016559)3.31626178
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.30385372
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.29536579
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29536579
41signal transduction involved in cell cycle checkpoint (GO:0072395)3.26486529
42protein-cofactor linkage (GO:0018065)3.26284339
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24504855
447-methylguanosine mRNA capping (GO:0006370)3.24449173
45COPII vesicle coating (GO:0048208)3.22406198
46mitotic metaphase plate congression (GO:0007080)3.19924262
47nucleotide transmembrane transport (GO:1901679)3.19366345
48histone arginine methylation (GO:0034969)3.16240275
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16159843
50response to pheromone (GO:0019236)3.15966031
51negative regulation of glycogen metabolic process (GO:0070874)3.15704369
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15180077
53negative regulation of ligase activity (GO:0051352)3.15180077
54RNA capping (GO:0036260)3.14797399
557-methylguanosine RNA capping (GO:0009452)3.14797399
56myeloid dendritic cell differentiation (GO:0043011)3.13915808
57ether lipid metabolic process (GO:0046485)3.13093047
58attachment of spindle microtubules to kinetochore (GO:0008608)3.09841383
59type B pancreatic cell proliferation (GO:0044342)3.09620322
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05276127
61spliceosomal snRNP assembly (GO:0000387)3.04443536
62negative regulation of telomere maintenance (GO:0032205)3.01954305
63intracellular protein transmembrane import (GO:0044743)2.99220807
64DNA deamination (GO:0045006)2.98912023
65inner mitochondrial membrane organization (GO:0007007)2.97783121
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96900673
67DNA excision (GO:0044349)2.95513392
68nucleotide-excision repair, DNA damage removal (GO:0000718)2.95513392
69protein peptidyl-prolyl isomerization (GO:0000413)2.95414087
70nucleotide-sugar biosynthetic process (GO:0009226)2.95266657
71negative regulation of DNA-dependent DNA replication (GO:2000104)2.93889520
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93662573
73positive regulation of prostaglandin secretion (GO:0032308)2.93153820
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90381526
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89956691
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.89293618
77termination of RNA polymerase III transcription (GO:0006386)2.89293618
78GDP-mannose metabolic process (GO:0019673)2.88434320
79regulation of cellular amine metabolic process (GO:0033238)2.88401125
80water-soluble vitamin biosynthetic process (GO:0042364)2.81384927
81intra-S DNA damage checkpoint (GO:0031573)2.80546950
82positive regulation of ligase activity (GO:0051351)2.77473000
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74287026
84regulation of mitotic spindle checkpoint (GO:1903504)2.74287026
85protein targeting to mitochondrion (GO:0006626)2.74170257
86IMP biosynthetic process (GO:0006188)2.72925765
87negative regulation of T-helper cell differentiation (GO:0045623)2.72131002
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72131002
89regulation of T cell cytokine production (GO:0002724)2.71940016
90cytokine biosynthetic process (GO:0042089)2.71836593
91interleukin-1-mediated signaling pathway (GO:0070498)2.71140412
92ATP synthesis coupled proton transport (GO:0015986)2.69138246
93energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69138246
94establishment of protein localization to mitochondrion (GO:0072655)2.69007209
95positive regulation of uterine smooth muscle contraction (GO:0070474)2.63005451
96tRNA modification (GO:0006400)2.61191905
97glycerol ether metabolic process (GO:0006662)2.59737737
98T-helper 1 type immune response (GO:0042088)2.59661879
99positive regulation of cell cycle arrest (GO:0071158)2.59579679
100branched-chain amino acid catabolic process (GO:0009083)2.59216779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59257189
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.31482419
3ZNF274_21170338_ChIP-Seq_K562_Hela4.23422928
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.82561113
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45904042
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45050352
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.33826266
8VDR_22108803_ChIP-Seq_LS180_Human3.32414012
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27016148
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09654377
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.01561456
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.81442714
13IGF1R_20145208_ChIP-Seq_DFB_Human2.74101555
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72620673
15VDR_23849224_ChIP-Seq_CD4+_Human2.58523436
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.57730823
17DCP1A_22483619_ChIP-Seq_HELA_Human2.50971292
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27879474
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27819829
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.23605409
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21467427
22ELK1_19687146_ChIP-ChIP_HELA_Human2.16272651
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15278524
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.98690728
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95233797
26TTF2_22483619_ChIP-Seq_HELA_Human1.83681961
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80377039
28GABP_19822575_ChIP-Seq_HepG2_Human1.75052336
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68653212
30FOXP3_21729870_ChIP-Seq_TREG_Human1.66928793
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54061033
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52884710
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50268052
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.50131912
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47677319
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47278785
37CIITA_25753668_ChIP-Seq_RAJI_Human1.46387512
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43032665
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41789549
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41079625
41MYC_18940864_ChIP-ChIP_HL60_Human1.40352404
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.40068314
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38087460
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36139076
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35067809
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33190105
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.32989975
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29836501
49TAF15_26573619_Chip-Seq_HEK293_Human1.28659537
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28291411
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28237945
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28234467
53TP53_22573176_ChIP-Seq_HFKS_Human1.27288603
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26520900
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25813949
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24425084
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23449609
58ELF5_23300383_ChIP-Seq_T47D_Human1.22157442
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17928948
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15736348
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15195165
62KDM5A_27292631_Chip-Seq_BREAST_Human1.14322610
63CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14296446
64XRN2_22483619_ChIP-Seq_HELA_Human1.12685494
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11520293
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05309406
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03882554
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.02763874
69P300_18555785_Chip-Seq_ESCs_Mouse1.02633021
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.01708407
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01495026
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.01034271
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00954803
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00736985
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00691691
76ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99742975
77SOX2_18555785_Chip-Seq_ESCs_Mouse0.99099969
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98823421
79OCT4_20526341_ChIP-Seq_ESCs_Human0.98084879
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.98062496
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97807346
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97473053
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95154054
84P53_22387025_ChIP-Seq_ESCs_Mouse0.94145818
85E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93343199
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92077847
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90197351
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90020193
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.89568422
90ZFX_18555785_Chip-Seq_ESCs_Mouse0.88850258
91IRF1_19129219_ChIP-ChIP_H3396_Human0.88759519
92MYC_19829295_ChIP-Seq_ESCs_Human0.88661611
93CTCF_18555785_Chip-Seq_ESCs_Mouse0.88587345
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88433205
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.87890881
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87660180
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86972048
98RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86300101
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.84248833
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82828180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok4.80453802
2MP0005645_abnormal_hypothalamus_physiol3.60683704
3MP0003806_abnormal_nucleotide_metabolis3.56018355
4MP0001529_abnormal_vocalization3.38270570
5MP0006276_abnormal_autonomic_nervous3.24958057
6MP0009785_altered_susceptibility_to2.90327940
7MP0001849_ear_inflammation2.80062111
8MP0005187_abnormal_penis_morphology2.59231240
9MP0002933_joint_inflammation2.33539739
10MP0001790_abnormal_immune_system2.27228329
11MP0005387_immune_system_phenotype2.27228329
12MP0002736_abnormal_nociception_after2.21463645
13MP0008872_abnormal_physiological_respon2.18943578
14MP0005671_abnormal_response_to2.14218858
15MP0005083_abnormal_biliary_tract2.01141427
16MP0003011_delayed_dark_adaptation1.94012807
17MP0008873_increased_physiological_sensi1.93308081
18MP0001986_abnormal_taste_sensitivity1.91054516
19MP0001968_abnormal_touch/_nociception1.86628227
20MP0000647_abnormal_sebaceous_gland1.81937881
21MP0004957_abnormal_blastocyst_morpholog1.80339159
22MP0002095_abnormal_skin_pigmentation1.77287146
23MP0008058_abnormal_DNA_repair1.71596400
24MP0005379_endocrine/exocrine_gland_phen1.68474484
25MP0003436_decreased_susceptibility_to1.66245249
26MP0002822_catalepsy1.64145616
27MP0000490_abnormal_crypts_of1.54865555
28MP0002254_reproductive_system_inflammat1.54434575
29MP0010155_abnormal_intestine_physiology1.48880877
30MP0004859_abnormal_synaptic_plasticity1.45039710
31MP0005253_abnormal_eye_physiology1.44224794
32MP0002163_abnormal_gland_morphology1.43114543
33MP0001905_abnormal_dopamine_level1.39256728
34MP0009780_abnormal_chondrocyte_physiolo1.38920682
35MP0001188_hyperpigmentation1.32629141
36MP0006072_abnormal_retinal_apoptosis1.32558720
37MP0001764_abnormal_homeostasis1.27465348
38MP0003786_premature_aging1.26494892
39MP0002148_abnormal_hypersensitivity_rea1.22927850
40MP0002102_abnormal_ear_morphology1.22781884
41MP0010094_abnormal_chromosome_stability1.22605513
42MP0005085_abnormal_gallbladder_physiolo1.20536265
43MP0001502_abnormal_circadian_rhythm1.12463360
44MP0002405_respiratory_system_inflammati1.12329377
45MP0003718_maternal_effect1.12218028
46MP0004885_abnormal_endolymph1.09182873
47MP0004133_heterotaxia1.04552443
48MP0004742_abnormal_vestibular_system1.04323049
49MP0001853_heart_inflammation1.03276473
50MP0002733_abnormal_thermal_nociception1.01557657
51MP0004043_abnormal_pH_regulation1.01142582
52MP0000427_abnormal_hair_cycle1.01094430
53MP0002557_abnormal_social/conspecific_i1.00147312
54MP0005319_abnormal_enzyme/_coenzyme0.98365989
55MP0004270_analgesia0.97309823
56MP0005084_abnormal_gallbladder_morpholo0.97283830
57MP0001661_extended_life_span0.97117731
58MP0003878_abnormal_ear_physiology0.96181769
59MP0005377_hearing/vestibular/ear_phenot0.96181769
60MP0004019_abnormal_vitamin_homeostasis0.94603442
61MP0005584_abnormal_enzyme/coenzyme_acti0.93869018
62MP0003119_abnormal_digestive_system0.92985333
63MP0001533_abnormal_skeleton_physiology0.90661925
64MP0003763_abnormal_thymus_physiology0.89983262
65MP0003693_abnormal_embryo_hatching0.88293749
66MP0004142_abnormal_muscle_tone0.87388781
67MP0001485_abnormal_pinna_reflex0.86057290
68MP0008770_decreased_survivor_rate0.85434824
69MP0001873_stomach_inflammation0.83469859
70MP0008569_lethality_at_weaning0.82198873
71MP0009697_abnormal_copulation0.81731996
72MP0001970_abnormal_pain_threshold0.81609717
73MP0009745_abnormal_behavioral_response0.81362694
74MP0005551_abnormal_eye_electrophysiolog0.81095448
75MP0006036_abnormal_mitochondrial_physio0.79871198
76MP0004782_abnormal_surfactant_physiolog0.78455394
77MP0005636_abnormal_mineral_homeostasis0.75558091
78MP0000747_muscle_weakness0.74976901
79MP0008469_abnormal_protein_level0.73866212
80MP0001243_abnormal_dermal_layer0.72848027
81MP0003252_abnormal_bile_duct0.72031799
82MP0004147_increased_porphyrin_level0.71832998
83MP0000653_abnormal_sex_gland0.71175107
84MP0002210_abnormal_sex_determination0.71065417
85MP0001765_abnormal_ion_homeostasis0.70290374
86MP0002067_abnormal_sensory_capabilities0.70268593
87MP0001216_abnormal_epidermal_layer0.70203912
88MP0003698_abnormal_male_reproductive0.67404715
89MP0002572_abnormal_emotion/affect_behav0.67203604
90MP0002735_abnormal_chemical_nociception0.67183383
91MP0002653_abnormal_ependyma_morphology0.66805545
92MP0004924_abnormal_behavior0.66642876
93MP0005386_behavior/neurological_phenoty0.66642876
94MP0003866_abnormal_defecation0.65926812
95MP0000013_abnormal_adipose_tissue0.64742268
96MP0002138_abnormal_hepatobiliary_system0.64178236
97MP0003077_abnormal_cell_cycle0.63985211
98MP0001919_abnormal_reproductive_system0.62432297
99MP0001145_abnormal_male_reproductive0.61120549
100MP0001929_abnormal_gametogenesis0.59220758

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.81195337
2Methylmalonic acidemia (HP:0002912)4.63384284
3Increased hepatocellular lipid droplets (HP:0006565)4.45178519
4Congenital, generalized hypertrichosis (HP:0004540)4.02636328
5Median cleft lip (HP:0000161)3.90499746
6Acute necrotizing encephalopathy (HP:0006965)3.78139586
7Methylmalonic aciduria (HP:0012120)3.59618284
8Increased CSF lactate (HP:0002490)3.54173516
9Mitochondrial inheritance (HP:0001427)3.51890475
10Abnormal mitochondria in muscle tissue (HP:0008316)3.49532109
11Hypoplasia of the pons (HP:0012110)3.46748546
12Tongue fasciculations (HP:0001308)3.35339538
13Progressive macrocephaly (HP:0004481)3.33238827
14Increased intramyocellular lipid droplets (HP:0012240)3.18604398
15Entropion (HP:0000621)3.15808576
16Submucous cleft hard palate (HP:0000176)3.10870737
17Renal Fanconi syndrome (HP:0001994)3.05487212
18Acute encephalopathy (HP:0006846)3.04245431
19Increased muscle lipid content (HP:0009058)3.03516531
20Abnormality of the pons (HP:0007361)2.95226250
21Homocystinuria (HP:0002156)2.89940102
22Abnormality of homocysteine metabolism (HP:0010919)2.89940102
233-Methylglutaconic aciduria (HP:0003535)2.86720565
24Brittle hair (HP:0002299)2.79414169
25Muscle fibrillation (HP:0010546)2.78849084
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75761064
27Abnormality of the vitamin B12 metabolism (HP:0004341)2.74440621
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74219303
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74219303
30Abnormality of the distal phalanges of the toes (HP:0010182)2.69443734
31Prominent metopic ridge (HP:0005487)2.66645180
32Cerebral edema (HP:0002181)2.62985561
33Nonimmune hydrops fetalis (HP:0001790)2.61960104
34Restlessness (HP:0000711)2.59002871
35Abnormality of vitamin B metabolism (HP:0004340)2.54311832
36Abnormality of methionine metabolism (HP:0010901)2.53338368
37CNS hypomyelination (HP:0003429)2.52178187
38Respiratory difficulties (HP:0002880)2.50896310
39Inability to walk (HP:0002540)2.47741337
40Agitation (HP:0000713)2.47366354
4111 pairs of ribs (HP:0000878)2.46688222
42Hepatocellular necrosis (HP:0001404)2.42632861
43Absent speech (HP:0001344)2.40081630
44Malignant hyperthermia (HP:0002047)2.35488078
45Periodontitis (HP:0000704)2.33721696
46Premature loss of primary teeth (HP:0006323)2.33192277
47Dicarboxylic aciduria (HP:0003215)2.29534584
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29534584
49Hepatic necrosis (HP:0002605)2.28542342
50Severe muscular hypotonia (HP:0006829)2.27985310
51Exercise intolerance (HP:0003546)2.25356024
52Progressive microcephaly (HP:0000253)2.24545536
53Progressive inability to walk (HP:0002505)2.23527186
54Increased serum lactate (HP:0002151)2.23510420
55Chronic mucocutaneous candidiasis (HP:0002728)2.23371171
56Recurrent cutaneous fungal infections (HP:0011370)2.23371171
57Cheilitis (HP:0100825)2.23146241
58Opisthotonus (HP:0002179)2.22475896
59Type II lissencephaly (HP:0007260)2.21586519
60Epiphyseal stippling (HP:0010655)2.18429195
61Glucose intolerance (HP:0000833)2.16515276
62Postaxial foot polydactyly (HP:0001830)2.14301054
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12184045
64Lactic acidosis (HP:0003128)2.11930574
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11536597
66Short nail (HP:0001799)2.11327918
67Exertional dyspnea (HP:0002875)2.09111887
68Delayed CNS myelination (HP:0002188)2.06841107
69Abnormality of the metopic suture (HP:0005556)2.06419267
70Generalized aminoaciduria (HP:0002909)2.04732611
71Bony spicule pigmentary retinopathy (HP:0007737)2.03346664
72Limb-girdle muscle atrophy (HP:0003797)2.03172886
73Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03126893
74Hypoplasia of the brainstem (HP:0002365)2.03126893
75Cerebral hypomyelination (HP:0006808)2.02123982
76Congenital sensorineural hearing impairment (HP:0008527)2.00326047
77Symptomatic seizures (HP:0011145)2.00201856
78Hypoglycemic seizures (HP:0002173)2.00067604
79Late onset (HP:0003584)1.95562054
80Lethargy (HP:0001254)1.94376881
81Hypoglycemic coma (HP:0001325)1.91822615
82Pancreatic islet-cell hyperplasia (HP:0004510)1.90605550
83Leukodystrophy (HP:0002415)1.90071532
84Clumsiness (HP:0002312)1.89152198
85Sparse eyelashes (HP:0000653)1.88503581
86Toxemia of pregnancy (HP:0100603)1.88473301
87Bifid uvula (HP:0000193)1.87362184
88Hyperphosphaturia (HP:0003109)1.86525326
89Abnormality of sulfur amino acid metabolism (HP:0004339)1.85886307
90Cerebellar dysplasia (HP:0007033)1.83406186
91Abnormality of renal resorption (HP:0011038)1.83291211
92Hyperbilirubinemia (HP:0002904)1.82539040
93Back pain (HP:0003418)1.82109285
94Global brain atrophy (HP:0002283)1.81268908
95Long clavicles (HP:0000890)1.80757802
96Abnormality of midbrain morphology (HP:0002418)1.77115500
97Molar tooth sign on MRI (HP:0002419)1.77115500
98Prolonged partial thromboplastin time (HP:0003645)1.75963759
99Shoulder girdle muscle weakness (HP:0003547)1.73900977
100Hypothermia (HP:0002045)1.72975543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK18.93456624
2MAP4K25.38517218
3TLK13.93739794
4TSSK63.84968751
5TXK2.39421310
6MST42.37987101
7ZAK2.25224586
8MAP3K122.22590707
9MAP2K72.21503445
10CLK12.03466942
11MAP3K41.96811797
12BCKDK1.90711833
13CSNK1G21.76228005
14OXSR11.71508174
15PHKG21.71494638
16PHKG11.71494638
17BUB11.50765985
18CSNK1G31.47159339
19MAPK131.45570492
20CSNK1A1L1.42307981
21BCR1.32526672
22WNK41.32413085
23BLK1.29641365
24VRK21.28769338
25VRK11.25407633
26LMTK21.11896333
27CASK1.09251332
28SRPK11.07712631
29CSNK1G11.01926865
30ADRBK21.01028951
31STK38L0.94966813
32STK390.93003226
33MAPKAPK30.92306489
34STK160.90019282
35ALK0.89761109
36MUSK0.87609628
37PRKD30.85286833
38MARK10.82544853
39EPHA20.71891468
40TTK0.69229201
41PLK30.67592145
42FGFR10.64210152
43TESK20.62502301
44PRKCH0.61600850
45EPHA30.60807783
46GRK60.60064656
47CDK190.59970760
48RPS6KA50.58914515
49DAPK20.55662179
50MAP3K30.55547153
51TESK10.55273824
52NME10.54645934
53ACVR1B0.54096029
54MST1R0.52647014
55PRKCE0.51069696
56PIM20.49385543
57LIMK10.49011372
58MAPKAPK50.48503140
59EEF2K0.48446028
60MYLK0.47704001
61AURKA0.45664856
62PBK0.44213408
63FER0.42283705
64TRIM280.42056121
65MATK0.40390975
66PRKCG0.39684417
67ATR0.38386400
68PAK40.36953238
69EIF2AK20.36327054
70TIE10.34465596
71MAP2K60.34218344
72CDK150.33842495
73CDK180.33803260
74TGFBR20.33784578
75RPS6KB20.32804945
76RPS6KB10.32788946
77PRKCI0.31343928
78DYRK20.31174343
79CDK11A0.30044481
80CDK140.28869508
81MAPK90.28842300
82TAOK20.28389048
83PLK10.27682483
84CAMK2A0.27661959
85FRK0.27136547
86JAK30.26604495
87CHUK0.26367485
88MAP3K140.26062297
89CSNK2A10.25863322
90EIF2AK30.25706139
91CDK70.23024629
92AURKB0.22737282
93PKN10.21830572
94PRKACB0.20959717
95CAMKK20.20442269
96IKBKB0.19650020
97ATM0.19564585
98TAOK30.18598957
99GRK10.16330774
100PRKCA0.15524254

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.19344254
2Proteasome_Homo sapiens_hsa030504.79490450
3Oxidative phosphorylation_Homo sapiens_hsa001902.86231016
4Parkinsons disease_Homo sapiens_hsa050122.81115200
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64926528
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.56002015
7Protein export_Homo sapiens_hsa030602.48772667
8Phototransduction_Homo sapiens_hsa047442.19130163
9One carbon pool by folate_Homo sapiens_hsa006702.15310698
10RNA polymerase_Homo sapiens_hsa030202.08015396
11Sulfur relay system_Homo sapiens_hsa041222.07003993
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06194989
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91918187
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.89755840
15Huntingtons disease_Homo sapiens_hsa050161.82407287
16Sulfur metabolism_Homo sapiens_hsa009201.78046218
17Basal transcription factors_Homo sapiens_hsa030221.75322674
18Alzheimers disease_Homo sapiens_hsa050101.73623823
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71483847
20RNA degradation_Homo sapiens_hsa030181.59076457
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58218622
22Homologous recombination_Homo sapiens_hsa034401.55788910
23Propanoate metabolism_Homo sapiens_hsa006401.51779287
24Mismatch repair_Homo sapiens_hsa034301.50373100
25Spliceosome_Homo sapiens_hsa030401.44906093
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43207090
27Selenocompound metabolism_Homo sapiens_hsa004501.40135311
28Ether lipid metabolism_Homo sapiens_hsa005651.39903219
29Peroxisome_Homo sapiens_hsa041461.33844732
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25446245
31Nucleotide excision repair_Homo sapiens_hsa034201.24530647
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23297650
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22354324
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19669168
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17685848
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.14981079
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12429068
38Nitrogen metabolism_Homo sapiens_hsa009101.10337870
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07439374
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04907984
41Cardiac muscle contraction_Homo sapiens_hsa042600.98125460
42Tryptophan metabolism_Homo sapiens_hsa003800.95925118
43Base excision repair_Homo sapiens_hsa034100.94370293
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92597871
45RNA transport_Homo sapiens_hsa030130.90815483
46Systemic lupus erythematosus_Homo sapiens_hsa053220.90630064
47Fatty acid elongation_Homo sapiens_hsa000620.90461211
48Collecting duct acid secretion_Homo sapiens_hsa049660.89881493
49Alcoholism_Homo sapiens_hsa050340.87296414
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86909447
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84196463
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83188526
53Pyrimidine metabolism_Homo sapiens_hsa002400.80294451
54Butanoate metabolism_Homo sapiens_hsa006500.78307705
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77300350
56Regulation of autophagy_Homo sapiens_hsa041400.76573366
57Metabolic pathways_Homo sapiens_hsa011000.76466529
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76239627
59Purine metabolism_Homo sapiens_hsa002300.75954309
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74041903
61beta-Alanine metabolism_Homo sapiens_hsa004100.73430150
62Folate biosynthesis_Homo sapiens_hsa007900.73237129
63Circadian rhythm_Homo sapiens_hsa047100.71740375
64Fatty acid metabolism_Homo sapiens_hsa012120.67149362
65Glutathione metabolism_Homo sapiens_hsa004800.63747632
66GABAergic synapse_Homo sapiens_hsa047270.60607786
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57812411
68Chemical carcinogenesis_Homo sapiens_hsa052040.57687197
69Primary immunodeficiency_Homo sapiens_hsa053400.56816780
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.56329028
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55751967
72Vibrio cholerae infection_Homo sapiens_hsa051100.55499034
73Linoleic acid metabolism_Homo sapiens_hsa005910.52549124
74DNA replication_Homo sapiens_hsa030300.51393866
75Pyruvate metabolism_Homo sapiens_hsa006200.50495504
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49476433
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47264315
78Olfactory transduction_Homo sapiens_hsa047400.46052019
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.45264494
80Fanconi anemia pathway_Homo sapiens_hsa034600.41265099
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39550824
82Fatty acid degradation_Homo sapiens_hsa000710.37926484
83Retinol metabolism_Homo sapiens_hsa008300.36735491
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.34916873
85Salivary secretion_Homo sapiens_hsa049700.33845286
86Morphine addiction_Homo sapiens_hsa050320.33479144
87Synaptic vesicle cycle_Homo sapiens_hsa047210.33031414
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32617937
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.32051561
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.31813639
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31396444
92Epstein-Barr virus infection_Homo sapiens_hsa051690.29873740
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29850394
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29822936
95Carbon metabolism_Homo sapiens_hsa012000.28250252
96Measles_Homo sapiens_hsa051620.27705872
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24139392
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23808972
99Dopaminergic synapse_Homo sapiens_hsa047280.23705360
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23487652

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