

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of cytokine production involved in inflammatory response (GO:1900015) | 8.63921227 |
| 2 | negative regulation of thymocyte apoptotic process (GO:0070244) | 5.52985041 |
| 3 | positive regulation of transcription regulatory region DNA binding (GO:2000679) | 5.46220168 |
| 4 | cullin deneddylation (GO:0010388) | 5.39366878 |
| 5 | DNA double-strand break processing (GO:0000729) | 5.28973998 |
| 6 | DNA catabolic process, exonucleolytic (GO:0000738) | 5.22791236 |
| 7 | regulation of immunoglobulin secretion (GO:0051023) | 5.10939856 |
| 8 | protein deneddylation (GO:0000338) | 4.70703370 |
| 9 | DNA damage response, detection of DNA damage (GO:0042769) | 4.68206626 |
| 10 | positive regulation of T cell cytokine production (GO:0002726) | 4.63669364 |
| 11 | chaperone-mediated protein transport (GO:0072321) | 4.62380251 |
| 12 | positive regulation of osteoclast differentiation (GO:0045672) | 4.60377735 |
| 13 | membrane protein intracellular domain proteolysis (GO:0031293) | 4.44805406 |
| 14 | proteasome assembly (GO:0043248) | 4.32735781 |
| 15 | rRNA methylation (GO:0031167) | 4.27850351 |
| 16 | signal peptide processing (GO:0006465) | 4.27557122 |
| 17 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.25816677 |
| 18 | rRNA modification (GO:0000154) | 4.05434670 |
| 19 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.02298449 |
| 20 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 3.91657205 |
| 21 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.90209101 |
| 22 | pseudouridine synthesis (GO:0001522) | 3.87895734 |
| 23 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.83710416 |
| 24 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.68607271 |
| 25 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.55071041 |
| 26 | peptidyl-arginine N-methylation (GO:0035246) | 3.53248326 |
| 27 | peptidyl-arginine methylation (GO:0018216) | 3.53248326 |
| 28 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.44803250 |
| 29 | activated T cell proliferation (GO:0050798) | 3.40991237 |
| 30 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.37076748 |
| 31 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.37076748 |
| 32 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.37076748 |
| 33 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.35535185 |
| 34 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.34843547 |
| 35 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.34843547 |
| 36 | regulation of thymocyte apoptotic process (GO:0070243) | 3.34195111 |
| 37 | peroxisome fission (GO:0016559) | 3.31626178 |
| 38 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.30385372 |
| 39 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.29536579 |
| 40 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.29536579 |
| 41 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.26486529 |
| 42 | protein-cofactor linkage (GO:0018065) | 3.26284339 |
| 43 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.24504855 |
| 44 | 7-methylguanosine mRNA capping (GO:0006370) | 3.24449173 |
| 45 | COPII vesicle coating (GO:0048208) | 3.22406198 |
| 46 | mitotic metaphase plate congression (GO:0007080) | 3.19924262 |
| 47 | nucleotide transmembrane transport (GO:1901679) | 3.19366345 |
| 48 | histone arginine methylation (GO:0034969) | 3.16240275 |
| 49 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.16159843 |
| 50 | response to pheromone (GO:0019236) | 3.15966031 |
| 51 | negative regulation of glycogen metabolic process (GO:0070874) | 3.15704369 |
| 52 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.15180077 |
| 53 | negative regulation of ligase activity (GO:0051352) | 3.15180077 |
| 54 | RNA capping (GO:0036260) | 3.14797399 |
| 55 | 7-methylguanosine RNA capping (GO:0009452) | 3.14797399 |
| 56 | myeloid dendritic cell differentiation (GO:0043011) | 3.13915808 |
| 57 | ether lipid metabolic process (GO:0046485) | 3.13093047 |
| 58 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.09841383 |
| 59 | type B pancreatic cell proliferation (GO:0044342) | 3.09620322 |
| 60 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.05276127 |
| 61 | spliceosomal snRNP assembly (GO:0000387) | 3.04443536 |
| 62 | negative regulation of telomere maintenance (GO:0032205) | 3.01954305 |
| 63 | intracellular protein transmembrane import (GO:0044743) | 2.99220807 |
| 64 | DNA deamination (GO:0045006) | 2.98912023 |
| 65 | inner mitochondrial membrane organization (GO:0007007) | 2.97783121 |
| 66 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.96900673 |
| 67 | DNA excision (GO:0044349) | 2.95513392 |
| 68 | nucleotide-excision repair, DNA damage removal (GO:0000718) | 2.95513392 |
| 69 | protein peptidyl-prolyl isomerization (GO:0000413) | 2.95414087 |
| 70 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.95266657 |
| 71 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.93889520 |
| 72 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.93662573 |
| 73 | positive regulation of prostaglandin secretion (GO:0032308) | 2.93153820 |
| 74 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.90381526 |
| 75 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.89956691 |
| 76 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.89293618 |
| 77 | termination of RNA polymerase III transcription (GO:0006386) | 2.89293618 |
| 78 | GDP-mannose metabolic process (GO:0019673) | 2.88434320 |
| 79 | regulation of cellular amine metabolic process (GO:0033238) | 2.88401125 |
| 80 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.81384927 |
| 81 | intra-S DNA damage checkpoint (GO:0031573) | 2.80546950 |
| 82 | positive regulation of ligase activity (GO:0051351) | 2.77473000 |
| 83 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.74287026 |
| 84 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.74287026 |
| 85 | protein targeting to mitochondrion (GO:0006626) | 2.74170257 |
| 86 | IMP biosynthetic process (GO:0006188) | 2.72925765 |
| 87 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.72131002 |
| 88 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.72131002 |
| 89 | regulation of T cell cytokine production (GO:0002724) | 2.71940016 |
| 90 | cytokine biosynthetic process (GO:0042089) | 2.71836593 |
| 91 | interleukin-1-mediated signaling pathway (GO:0070498) | 2.71140412 |
| 92 | ATP synthesis coupled proton transport (GO:0015986) | 2.69138246 |
| 93 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.69138246 |
| 94 | establishment of protein localization to mitochondrion (GO:0072655) | 2.69007209 |
| 95 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 2.63005451 |
| 96 | tRNA modification (GO:0006400) | 2.61191905 |
| 97 | glycerol ether metabolic process (GO:0006662) | 2.59737737 |
| 98 | T-helper 1 type immune response (GO:0042088) | 2.59661879 |
| 99 | positive regulation of cell cycle arrest (GO:0071158) | 2.59579679 |
| 100 | branched-chain amino acid catabolic process (GO:0009083) | 2.59216779 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.59257189 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.31482419 |
| 3 | ZNF274_21170338_ChIP-Seq_K562_Hela | 4.23422928 |
| 4 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 3.82561113 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.45904042 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.45050352 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.33826266 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 3.32414012 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.27016148 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.09654377 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.01561456 |
| 12 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.81442714 |
| 13 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.74101555 |
| 14 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.72620673 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.58523436 |
| 16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.57730823 |
| 17 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.50971292 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.27879474 |
| 19 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.27819829 |
| 20 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.23605409 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.21467427 |
| 22 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.16272651 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.15278524 |
| 24 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.98690728 |
| 25 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.95233797 |
| 26 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.83681961 |
| 27 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.80377039 |
| 28 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.75052336 |
| 29 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.68653212 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.66928793 |
| 31 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.54061033 |
| 32 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.52884710 |
| 33 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.50268052 |
| 34 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.50131912 |
| 35 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.47677319 |
| 36 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.47278785 |
| 37 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.46387512 |
| 38 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.43032665 |
| 39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.41789549 |
| 40 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.41079625 |
| 41 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.40352404 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.40068314 |
| 43 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.38087460 |
| 44 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.36139076 |
| 45 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.35067809 |
| 46 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.33190105 |
| 47 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.32989975 |
| 48 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29836501 |
| 49 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.28659537 |
| 50 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.28291411 |
| 51 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.28237945 |
| 52 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.28234467 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.27288603 |
| 54 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.26520900 |
| 55 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25813949 |
| 56 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.24425084 |
| 57 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.23449609 |
| 58 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.22157442 |
| 59 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.17928948 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.15736348 |
| 61 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.15195165 |
| 62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.14322610 |
| 63 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.14296446 |
| 64 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.12685494 |
| 65 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.11520293 |
| 66 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05309406 |
| 67 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.03882554 |
| 68 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.02763874 |
| 69 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.02633021 |
| 70 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.01708407 |
| 71 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.01495026 |
| 72 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.01034271 |
| 73 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.00954803 |
| 74 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.00736985 |
| 75 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.00691691 |
| 76 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.99742975 |
| 77 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.99099969 |
| 78 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.98823421 |
| 79 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.98084879 |
| 80 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.98062496 |
| 81 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.97807346 |
| 82 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.97473053 |
| 83 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.95154054 |
| 84 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.94145818 |
| 85 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.93343199 |
| 86 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.92077847 |
| 87 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.90197351 |
| 88 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.90020193 |
| 89 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89568422 |
| 90 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.88850258 |
| 91 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.88759519 |
| 92 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.88661611 |
| 93 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 0.88587345 |
| 94 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.88433205 |
| 95 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.87890881 |
| 96 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.87660180 |
| 97 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.86972048 |
| 98 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.86300101 |
| 99 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.84248833 |
| 100 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.82828180 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008875_abnormal_xenobiotic_pharmacok | 4.80453802 |
| 2 | MP0005645_abnormal_hypothalamus_physiol | 3.60683704 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.56018355 |
| 4 | MP0001529_abnormal_vocalization | 3.38270570 |
| 5 | MP0006276_abnormal_autonomic_nervous | 3.24958057 |
| 6 | MP0009785_altered_susceptibility_to | 2.90327940 |
| 7 | MP0001849_ear_inflammation | 2.80062111 |
| 8 | MP0005187_abnormal_penis_morphology | 2.59231240 |
| 9 | MP0002933_joint_inflammation | 2.33539739 |
| 10 | MP0001790_abnormal_immune_system | 2.27228329 |
| 11 | MP0005387_immune_system_phenotype | 2.27228329 |
| 12 | MP0002736_abnormal_nociception_after | 2.21463645 |
| 13 | MP0008872_abnormal_physiological_respon | 2.18943578 |
| 14 | MP0005671_abnormal_response_to | 2.14218858 |
| 15 | MP0005083_abnormal_biliary_tract | 2.01141427 |
| 16 | MP0003011_delayed_dark_adaptation | 1.94012807 |
| 17 | MP0008873_increased_physiological_sensi | 1.93308081 |
| 18 | MP0001986_abnormal_taste_sensitivity | 1.91054516 |
| 19 | MP0001968_abnormal_touch/_nociception | 1.86628227 |
| 20 | MP0000647_abnormal_sebaceous_gland | 1.81937881 |
| 21 | MP0004957_abnormal_blastocyst_morpholog | 1.80339159 |
| 22 | MP0002095_abnormal_skin_pigmentation | 1.77287146 |
| 23 | MP0008058_abnormal_DNA_repair | 1.71596400 |
| 24 | MP0005379_endocrine/exocrine_gland_phen | 1.68474484 |
| 25 | MP0003436_decreased_susceptibility_to | 1.66245249 |
| 26 | MP0002822_catalepsy | 1.64145616 |
| 27 | MP0000490_abnormal_crypts_of | 1.54865555 |
| 28 | MP0002254_reproductive_system_inflammat | 1.54434575 |
| 29 | MP0010155_abnormal_intestine_physiology | 1.48880877 |
| 30 | MP0004859_abnormal_synaptic_plasticity | 1.45039710 |
| 31 | MP0005253_abnormal_eye_physiology | 1.44224794 |
| 32 | MP0002163_abnormal_gland_morphology | 1.43114543 |
| 33 | MP0001905_abnormal_dopamine_level | 1.39256728 |
| 34 | MP0009780_abnormal_chondrocyte_physiolo | 1.38920682 |
| 35 | MP0001188_hyperpigmentation | 1.32629141 |
| 36 | MP0006072_abnormal_retinal_apoptosis | 1.32558720 |
| 37 | MP0001764_abnormal_homeostasis | 1.27465348 |
| 38 | MP0003786_premature_aging | 1.26494892 |
| 39 | MP0002148_abnormal_hypersensitivity_rea | 1.22927850 |
| 40 | MP0002102_abnormal_ear_morphology | 1.22781884 |
| 41 | MP0010094_abnormal_chromosome_stability | 1.22605513 |
| 42 | MP0005085_abnormal_gallbladder_physiolo | 1.20536265 |
| 43 | MP0001502_abnormal_circadian_rhythm | 1.12463360 |
| 44 | MP0002405_respiratory_system_inflammati | 1.12329377 |
| 45 | MP0003718_maternal_effect | 1.12218028 |
| 46 | MP0004885_abnormal_endolymph | 1.09182873 |
| 47 | MP0004133_heterotaxia | 1.04552443 |
| 48 | MP0004742_abnormal_vestibular_system | 1.04323049 |
| 49 | MP0001853_heart_inflammation | 1.03276473 |
| 50 | MP0002733_abnormal_thermal_nociception | 1.01557657 |
| 51 | MP0004043_abnormal_pH_regulation | 1.01142582 |
| 52 | MP0000427_abnormal_hair_cycle | 1.01094430 |
| 53 | MP0002557_abnormal_social/conspecific_i | 1.00147312 |
| 54 | MP0005319_abnormal_enzyme/_coenzyme | 0.98365989 |
| 55 | MP0004270_analgesia | 0.97309823 |
| 56 | MP0005084_abnormal_gallbladder_morpholo | 0.97283830 |
| 57 | MP0001661_extended_life_span | 0.97117731 |
| 58 | MP0003878_abnormal_ear_physiology | 0.96181769 |
| 59 | MP0005377_hearing/vestibular/ear_phenot | 0.96181769 |
| 60 | MP0004019_abnormal_vitamin_homeostasis | 0.94603442 |
| 61 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.93869018 |
| 62 | MP0003119_abnormal_digestive_system | 0.92985333 |
| 63 | MP0001533_abnormal_skeleton_physiology | 0.90661925 |
| 64 | MP0003763_abnormal_thymus_physiology | 0.89983262 |
| 65 | MP0003693_abnormal_embryo_hatching | 0.88293749 |
| 66 | MP0004142_abnormal_muscle_tone | 0.87388781 |
| 67 | MP0001485_abnormal_pinna_reflex | 0.86057290 |
| 68 | MP0008770_decreased_survivor_rate | 0.85434824 |
| 69 | MP0001873_stomach_inflammation | 0.83469859 |
| 70 | MP0008569_lethality_at_weaning | 0.82198873 |
| 71 | MP0009697_abnormal_copulation | 0.81731996 |
| 72 | MP0001970_abnormal_pain_threshold | 0.81609717 |
| 73 | MP0009745_abnormal_behavioral_response | 0.81362694 |
| 74 | MP0005551_abnormal_eye_electrophysiolog | 0.81095448 |
| 75 | MP0006036_abnormal_mitochondrial_physio | 0.79871198 |
| 76 | MP0004782_abnormal_surfactant_physiolog | 0.78455394 |
| 77 | MP0005636_abnormal_mineral_homeostasis | 0.75558091 |
| 78 | MP0000747_muscle_weakness | 0.74976901 |
| 79 | MP0008469_abnormal_protein_level | 0.73866212 |
| 80 | MP0001243_abnormal_dermal_layer | 0.72848027 |
| 81 | MP0003252_abnormal_bile_duct | 0.72031799 |
| 82 | MP0004147_increased_porphyrin_level | 0.71832998 |
| 83 | MP0000653_abnormal_sex_gland | 0.71175107 |
| 84 | MP0002210_abnormal_sex_determination | 0.71065417 |
| 85 | MP0001765_abnormal_ion_homeostasis | 0.70290374 |
| 86 | MP0002067_abnormal_sensory_capabilities | 0.70268593 |
| 87 | MP0001216_abnormal_epidermal_layer | 0.70203912 |
| 88 | MP0003698_abnormal_male_reproductive | 0.67404715 |
| 89 | MP0002572_abnormal_emotion/affect_behav | 0.67203604 |
| 90 | MP0002735_abnormal_chemical_nociception | 0.67183383 |
| 91 | MP0002653_abnormal_ependyma_morphology | 0.66805545 |
| 92 | MP0004924_abnormal_behavior | 0.66642876 |
| 93 | MP0005386_behavior/neurological_phenoty | 0.66642876 |
| 94 | MP0003866_abnormal_defecation | 0.65926812 |
| 95 | MP0000013_abnormal_adipose_tissue | 0.64742268 |
| 96 | MP0002138_abnormal_hepatobiliary_system | 0.64178236 |
| 97 | MP0003077_abnormal_cell_cycle | 0.63985211 |
| 98 | MP0001919_abnormal_reproductive_system | 0.62432297 |
| 99 | MP0001145_abnormal_male_reproductive | 0.61120549 |
| 100 | MP0001929_abnormal_gametogenesis | 0.59220758 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Lipid accumulation in hepatocytes (HP:0006561) | 4.81195337 |
| 2 | Methylmalonic acidemia (HP:0002912) | 4.63384284 |
| 3 | Increased hepatocellular lipid droplets (HP:0006565) | 4.45178519 |
| 4 | Congenital, generalized hypertrichosis (HP:0004540) | 4.02636328 |
| 5 | Median cleft lip (HP:0000161) | 3.90499746 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 3.78139586 |
| 7 | Methylmalonic aciduria (HP:0012120) | 3.59618284 |
| 8 | Increased CSF lactate (HP:0002490) | 3.54173516 |
| 9 | Mitochondrial inheritance (HP:0001427) | 3.51890475 |
| 10 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.49532109 |
| 11 | Hypoplasia of the pons (HP:0012110) | 3.46748546 |
| 12 | Tongue fasciculations (HP:0001308) | 3.35339538 |
| 13 | Progressive macrocephaly (HP:0004481) | 3.33238827 |
| 14 | Increased intramyocellular lipid droplets (HP:0012240) | 3.18604398 |
| 15 | Entropion (HP:0000621) | 3.15808576 |
| 16 | Submucous cleft hard palate (HP:0000176) | 3.10870737 |
| 17 | Renal Fanconi syndrome (HP:0001994) | 3.05487212 |
| 18 | Acute encephalopathy (HP:0006846) | 3.04245431 |
| 19 | Increased muscle lipid content (HP:0009058) | 3.03516531 |
| 20 | Abnormality of the pons (HP:0007361) | 2.95226250 |
| 21 | Homocystinuria (HP:0002156) | 2.89940102 |
| 22 | Abnormality of homocysteine metabolism (HP:0010919) | 2.89940102 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 2.86720565 |
| 24 | Brittle hair (HP:0002299) | 2.79414169 |
| 25 | Muscle fibrillation (HP:0010546) | 2.78849084 |
| 26 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.75761064 |
| 27 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.74440621 |
| 28 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.74219303 |
| 29 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.74219303 |
| 30 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.69443734 |
| 31 | Prominent metopic ridge (HP:0005487) | 2.66645180 |
| 32 | Cerebral edema (HP:0002181) | 2.62985561 |
| 33 | Nonimmune hydrops fetalis (HP:0001790) | 2.61960104 |
| 34 | Restlessness (HP:0000711) | 2.59002871 |
| 35 | Abnormality of vitamin B metabolism (HP:0004340) | 2.54311832 |
| 36 | Abnormality of methionine metabolism (HP:0010901) | 2.53338368 |
| 37 | CNS hypomyelination (HP:0003429) | 2.52178187 |
| 38 | Respiratory difficulties (HP:0002880) | 2.50896310 |
| 39 | Inability to walk (HP:0002540) | 2.47741337 |
| 40 | Agitation (HP:0000713) | 2.47366354 |
| 41 | 11 pairs of ribs (HP:0000878) | 2.46688222 |
| 42 | Hepatocellular necrosis (HP:0001404) | 2.42632861 |
| 43 | Absent speech (HP:0001344) | 2.40081630 |
| 44 | Malignant hyperthermia (HP:0002047) | 2.35488078 |
| 45 | Periodontitis (HP:0000704) | 2.33721696 |
| 46 | Premature loss of primary teeth (HP:0006323) | 2.33192277 |
| 47 | Dicarboxylic aciduria (HP:0003215) | 2.29534584 |
| 48 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.29534584 |
| 49 | Hepatic necrosis (HP:0002605) | 2.28542342 |
| 50 | Severe muscular hypotonia (HP:0006829) | 2.27985310 |
| 51 | Exercise intolerance (HP:0003546) | 2.25356024 |
| 52 | Progressive microcephaly (HP:0000253) | 2.24545536 |
| 53 | Progressive inability to walk (HP:0002505) | 2.23527186 |
| 54 | Increased serum lactate (HP:0002151) | 2.23510420 |
| 55 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.23371171 |
| 56 | Recurrent cutaneous fungal infections (HP:0011370) | 2.23371171 |
| 57 | Cheilitis (HP:0100825) | 2.23146241 |
| 58 | Opisthotonus (HP:0002179) | 2.22475896 |
| 59 | Type II lissencephaly (HP:0007260) | 2.21586519 |
| 60 | Epiphyseal stippling (HP:0010655) | 2.18429195 |
| 61 | Glucose intolerance (HP:0000833) | 2.16515276 |
| 62 | Postaxial foot polydactyly (HP:0001830) | 2.14301054 |
| 63 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.12184045 |
| 64 | Lactic acidosis (HP:0003128) | 2.11930574 |
| 65 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.11536597 |
| 66 | Short nail (HP:0001799) | 2.11327918 |
| 67 | Exertional dyspnea (HP:0002875) | 2.09111887 |
| 68 | Delayed CNS myelination (HP:0002188) | 2.06841107 |
| 69 | Abnormality of the metopic suture (HP:0005556) | 2.06419267 |
| 70 | Generalized aminoaciduria (HP:0002909) | 2.04732611 |
| 71 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.03346664 |
| 72 | Limb-girdle muscle atrophy (HP:0003797) | 2.03172886 |
| 73 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.03126893 |
| 74 | Hypoplasia of the brainstem (HP:0002365) | 2.03126893 |
| 75 | Cerebral hypomyelination (HP:0006808) | 2.02123982 |
| 76 | Congenital sensorineural hearing impairment (HP:0008527) | 2.00326047 |
| 77 | Symptomatic seizures (HP:0011145) | 2.00201856 |
| 78 | Hypoglycemic seizures (HP:0002173) | 2.00067604 |
| 79 | Late onset (HP:0003584) | 1.95562054 |
| 80 | Lethargy (HP:0001254) | 1.94376881 |
| 81 | Hypoglycemic coma (HP:0001325) | 1.91822615 |
| 82 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.90605550 |
| 83 | Leukodystrophy (HP:0002415) | 1.90071532 |
| 84 | Clumsiness (HP:0002312) | 1.89152198 |
| 85 | Sparse eyelashes (HP:0000653) | 1.88503581 |
| 86 | Toxemia of pregnancy (HP:0100603) | 1.88473301 |
| 87 | Bifid uvula (HP:0000193) | 1.87362184 |
| 88 | Hyperphosphaturia (HP:0003109) | 1.86525326 |
| 89 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.85886307 |
| 90 | Cerebellar dysplasia (HP:0007033) | 1.83406186 |
| 91 | Abnormality of renal resorption (HP:0011038) | 1.83291211 |
| 92 | Hyperbilirubinemia (HP:0002904) | 1.82539040 |
| 93 | Back pain (HP:0003418) | 1.82109285 |
| 94 | Global brain atrophy (HP:0002283) | 1.81268908 |
| 95 | Long clavicles (HP:0000890) | 1.80757802 |
| 96 | Abnormality of midbrain morphology (HP:0002418) | 1.77115500 |
| 97 | Molar tooth sign on MRI (HP:0002419) | 1.77115500 |
| 98 | Prolonged partial thromboplastin time (HP:0003645) | 1.75963759 |
| 99 | Shoulder girdle muscle weakness (HP:0003547) | 1.73900977 |
| 100 | Hypothermia (HP:0002045) | 1.72975543 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NEK1 | 8.93456624 |
| 2 | MAP4K2 | 5.38517218 |
| 3 | TLK1 | 3.93739794 |
| 4 | TSSK6 | 3.84968751 |
| 5 | TXK | 2.39421310 |
| 6 | MST4 | 2.37987101 |
| 7 | ZAK | 2.25224586 |
| 8 | MAP3K12 | 2.22590707 |
| 9 | MAP2K7 | 2.21503445 |
| 10 | CLK1 | 2.03466942 |
| 11 | MAP3K4 | 1.96811797 |
| 12 | BCKDK | 1.90711833 |
| 13 | CSNK1G2 | 1.76228005 |
| 14 | OXSR1 | 1.71508174 |
| 15 | PHKG2 | 1.71494638 |
| 16 | PHKG1 | 1.71494638 |
| 17 | BUB1 | 1.50765985 |
| 18 | CSNK1G3 | 1.47159339 |
| 19 | MAPK13 | 1.45570492 |
| 20 | CSNK1A1L | 1.42307981 |
| 21 | BCR | 1.32526672 |
| 22 | WNK4 | 1.32413085 |
| 23 | BLK | 1.29641365 |
| 24 | VRK2 | 1.28769338 |
| 25 | VRK1 | 1.25407633 |
| 26 | LMTK2 | 1.11896333 |
| 27 | CASK | 1.09251332 |
| 28 | SRPK1 | 1.07712631 |
| 29 | CSNK1G1 | 1.01926865 |
| 30 | ADRBK2 | 1.01028951 |
| 31 | STK38L | 0.94966813 |
| 32 | STK39 | 0.93003226 |
| 33 | MAPKAPK3 | 0.92306489 |
| 34 | STK16 | 0.90019282 |
| 35 | ALK | 0.89761109 |
| 36 | MUSK | 0.87609628 |
| 37 | PRKD3 | 0.85286833 |
| 38 | MARK1 | 0.82544853 |
| 39 | EPHA2 | 0.71891468 |
| 40 | TTK | 0.69229201 |
| 41 | PLK3 | 0.67592145 |
| 42 | FGFR1 | 0.64210152 |
| 43 | TESK2 | 0.62502301 |
| 44 | PRKCH | 0.61600850 |
| 45 | EPHA3 | 0.60807783 |
| 46 | GRK6 | 0.60064656 |
| 47 | CDK19 | 0.59970760 |
| 48 | RPS6KA5 | 0.58914515 |
| 49 | DAPK2 | 0.55662179 |
| 50 | MAP3K3 | 0.55547153 |
| 51 | TESK1 | 0.55273824 |
| 52 | NME1 | 0.54645934 |
| 53 | ACVR1B | 0.54096029 |
| 54 | MST1R | 0.52647014 |
| 55 | PRKCE | 0.51069696 |
| 56 | PIM2 | 0.49385543 |
| 57 | LIMK1 | 0.49011372 |
| 58 | MAPKAPK5 | 0.48503140 |
| 59 | EEF2K | 0.48446028 |
| 60 | MYLK | 0.47704001 |
| 61 | AURKA | 0.45664856 |
| 62 | PBK | 0.44213408 |
| 63 | FER | 0.42283705 |
| 64 | TRIM28 | 0.42056121 |
| 65 | MATK | 0.40390975 |
| 66 | PRKCG | 0.39684417 |
| 67 | ATR | 0.38386400 |
| 68 | PAK4 | 0.36953238 |
| 69 | EIF2AK2 | 0.36327054 |
| 70 | TIE1 | 0.34465596 |
| 71 | MAP2K6 | 0.34218344 |
| 72 | CDK15 | 0.33842495 |
| 73 | CDK18 | 0.33803260 |
| 74 | TGFBR2 | 0.33784578 |
| 75 | RPS6KB2 | 0.32804945 |
| 76 | RPS6KB1 | 0.32788946 |
| 77 | PRKCI | 0.31343928 |
| 78 | DYRK2 | 0.31174343 |
| 79 | CDK11A | 0.30044481 |
| 80 | CDK14 | 0.28869508 |
| 81 | MAPK9 | 0.28842300 |
| 82 | TAOK2 | 0.28389048 |
| 83 | PLK1 | 0.27682483 |
| 84 | CAMK2A | 0.27661959 |
| 85 | FRK | 0.27136547 |
| 86 | JAK3 | 0.26604495 |
| 87 | CHUK | 0.26367485 |
| 88 | MAP3K14 | 0.26062297 |
| 89 | CSNK2A1 | 0.25863322 |
| 90 | EIF2AK3 | 0.25706139 |
| 91 | CDK7 | 0.23024629 |
| 92 | AURKB | 0.22737282 |
| 93 | PKN1 | 0.21830572 |
| 94 | PRKACB | 0.20959717 |
| 95 | CAMKK2 | 0.20442269 |
| 96 | IKBKB | 0.19650020 |
| 97 | ATM | 0.19564585 |
| 98 | TAOK3 | 0.18598957 |
| 99 | GRK1 | 0.16330774 |
| 100 | PRKCA | 0.15524254 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.19344254 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.79490450 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.86231016 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.81115200 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.64926528 |
| 6 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.56002015 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.48772667 |
| 8 | Phototransduction_Homo sapiens_hsa04744 | 2.19130163 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.15310698 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.08015396 |
| 11 | Sulfur relay system_Homo sapiens_hsa04122 | 2.07003993 |
| 12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.06194989 |
| 13 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.91918187 |
| 14 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.89755840 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.82407287 |
| 16 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.78046218 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75322674 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.73623823 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.71483847 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.59076457 |
| 21 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.58218622 |
| 22 | Homologous recombination_Homo sapiens_hsa03440 | 1.55788910 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.51779287 |
| 24 | Mismatch repair_Homo sapiens_hsa03430 | 1.50373100 |
| 25 | Spliceosome_Homo sapiens_hsa03040 | 1.44906093 |
| 26 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.43207090 |
| 27 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.40135311 |
| 28 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.39903219 |
| 29 | Peroxisome_Homo sapiens_hsa04146 | 1.33844732 |
| 30 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.25446245 |
| 31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.24530647 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.23297650 |
| 33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.22354324 |
| 34 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.19669168 |
| 35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.17685848 |
| 36 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.14981079 |
| 37 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.12429068 |
| 38 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.10337870 |
| 39 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.07439374 |
| 40 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.04907984 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.98125460 |
| 42 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.95925118 |
| 43 | Base excision repair_Homo sapiens_hsa03410 | 0.94370293 |
| 44 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.92597871 |
| 45 | RNA transport_Homo sapiens_hsa03013 | 0.90815483 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.90630064 |
| 47 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.90461211 |
| 48 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.89881493 |
| 49 | Alcoholism_Homo sapiens_hsa05034 | 0.87296414 |
| 50 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.86909447 |
| 51 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.84196463 |
| 52 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.83188526 |
| 53 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.80294451 |
| 54 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.78307705 |
| 55 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.77300350 |
| 56 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76573366 |
| 57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76466529 |
| 58 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.76239627 |
| 59 | Purine metabolism_Homo sapiens_hsa00230 | 0.75954309 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.74041903 |
| 61 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.73430150 |
| 62 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73237129 |
| 63 | Circadian rhythm_Homo sapiens_hsa04710 | 0.71740375 |
| 64 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.67149362 |
| 65 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.63747632 |
| 66 | GABAergic synapse_Homo sapiens_hsa04727 | 0.60607786 |
| 67 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.57812411 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.57687197 |
| 69 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.56816780 |
| 70 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.56329028 |
| 71 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.55751967 |
| 72 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.55499034 |
| 73 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.52549124 |
| 74 | DNA replication_Homo sapiens_hsa03030 | 0.51393866 |
| 75 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50495504 |
| 76 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49476433 |
| 77 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.47264315 |
| 78 | Olfactory transduction_Homo sapiens_hsa04740 | 0.46052019 |
| 79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45264494 |
| 80 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.41265099 |
| 81 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39550824 |
| 82 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37926484 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36735491 |
| 84 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.34916873 |
| 85 | Salivary secretion_Homo sapiens_hsa04970 | 0.33845286 |
| 86 | Morphine addiction_Homo sapiens_hsa05032 | 0.33479144 |
| 87 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.33031414 |
| 88 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.32617937 |
| 89 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.32051561 |
| 90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31813639 |
| 91 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.31396444 |
| 92 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.29873740 |
| 93 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.29850394 |
| 94 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.29822936 |
| 95 | Carbon metabolism_Homo sapiens_hsa01200 | 0.28250252 |
| 96 | Measles_Homo sapiens_hsa05162 | 0.27705872 |
| 97 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24139392 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.23808972 |
| 99 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.23705360 |
| 100 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.23487652 |

