VDAC1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)5.51620433
2proteasome assembly (GO:0043248)5.29959065
3chaperone-mediated protein transport (GO:0072321)4.88772935
4cytidine catabolic process (GO:0006216)4.87543971
5cytidine deamination (GO:0009972)4.87543971
6cytidine metabolic process (GO:0046087)4.87543971
7glyoxylate metabolic process (GO:0046487)4.81557495
8DNA deamination (GO:0045006)4.64814908
9folic acid-containing compound biosynthetic process (GO:0009396)4.39619933
10regulation of cellular amino acid metabolic process (GO:0006521)4.22530688
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.12131904
12IMP biosynthetic process (GO:0006188)4.11312714
13rRNA modification (GO:0000154)4.10856771
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.08747829
15attachment of spindle microtubules to kinetochore (GO:0008608)4.06696957
16DNA catabolic process, exonucleolytic (GO:0000738)4.00531068
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.99410115
18pyrimidine ribonucleoside catabolic process (GO:0046133)3.98732760
19NADH dehydrogenase complex assembly (GO:0010257)3.96183761
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96183761
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.96183761
22protein peptidyl-prolyl isomerization (GO:0000413)3.95203139
23rRNA methylation (GO:0031167)3.94885063
24pseudouridine synthesis (GO:0001522)3.83656362
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79022906
26GTP biosynthetic process (GO:0006183)3.78538069
27nuclear pore organization (GO:0006999)3.77096571
28protein deneddylation (GO:0000338)3.76438026
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74941609
30IMP metabolic process (GO:0046040)3.73516117
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70643379
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70643379
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.70615737
34pteridine-containing compound biosynthetic process (GO:0042559)3.67181192
35cullin deneddylation (GO:0010388)3.65319735
36water-soluble vitamin biosynthetic process (GO:0042364)3.65194102
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.62674229
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.62674229
39protein complex biogenesis (GO:0070271)3.60444194
40UTP biosynthetic process (GO:0006228)3.60241746
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59842358
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59842358
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59842358
44glycine metabolic process (GO:0006544)3.59407440
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.58967701
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.58967701
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.58553530
48termination of RNA polymerase III transcription (GO:0006386)3.58553530
49regulation of chronic inflammatory response (GO:0002676)3.54860153
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.54272991
51eosinophil chemotaxis (GO:0048245)3.53220877
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47081333
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45575340
54ATP synthesis coupled proton transport (GO:0015986)3.45575340
55regulation of mononuclear cell migration (GO:0071675)3.42904421
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41235733
57mitochondrial respiratory chain complex assembly (GO:0033108)3.38919328
58tetrahydrofolate metabolic process (GO:0046653)3.35074057
59positive regulation of T cell chemotaxis (GO:0010820)3.34311248
60regulation of T cell chemotaxis (GO:0010819)3.34311248
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33680136
62negative regulation of ligase activity (GO:0051352)3.33680136
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32876543
64UTP metabolic process (GO:0046051)3.31033192
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29362847
66establishment of integrated proviral latency (GO:0075713)3.28211462
67regulation of cellular amine metabolic process (GO:0033238)3.27060770
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22224879
69peptidyl-proline modification (GO:0018208)3.21655825
70mitotic metaphase plate congression (GO:0007080)3.21247913
71nucleobase biosynthetic process (GO:0046112)3.18983779
72ribosome assembly (GO:0042255)3.18904984
73DNA integration (GO:0015074)3.18351030
74DNA damage response, detection of DNA damage (GO:0042769)3.17122621
75serine family amino acid catabolic process (GO:0009071)3.16991021
76L-phenylalanine catabolic process (GO:0006559)3.16159918
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16159918
78regulation of macrophage chemotaxis (GO:0010758)3.15611246
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15316430
80L-phenylalanine metabolic process (GO:0006558)3.15316430
81eosinophil migration (GO:0072677)3.14946061
82regulation of chemokine-mediated signaling pathway (GO:0070099)3.13846185
83positive regulation of ligase activity (GO:0051351)3.11337371
84serine family amino acid metabolic process (GO:0009069)3.09406792
85purine nucleobase biosynthetic process (GO:0009113)3.06396025
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02882513
87production of molecular mediator involved in inflammatory response (GO:0002532)3.02533218
887-methylguanosine mRNA capping (GO:0006370)2.93656134
89tRNA aminoacylation (GO:0043039)2.91863256
90amino acid activation (GO:0043038)2.91863256
91positive regulation of cell cycle arrest (GO:0071158)2.89065932
92metallo-sulfur cluster assembly (GO:0031163)2.88605905
93iron-sulfur cluster assembly (GO:0016226)2.88605905
94sterol biosynthetic process (GO:0016126)2.88270349
95tRNA aminoacylation for protein translation (GO:0006418)2.86412612
96DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.86035148
97RNA capping (GO:0036260)2.85557910
987-methylguanosine RNA capping (GO:0009452)2.85557910
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84737777
100positive regulation of T cell apoptotic process (GO:0070234)2.84737593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.03199810
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.86689267
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.56528372
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.45781264
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61928223
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.43824078
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.40436474
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.12507923
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10166498
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02729843
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.01610496
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80593113
13VDR_23849224_ChIP-Seq_CD4+_Human2.77314864
14E2F7_22180533_ChIP-Seq_HELA_Human2.75231987
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71721264
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64852008
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.54380069
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50760936
19ELK1_19687146_ChIP-ChIP_HELA_Human2.41709760
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.28415378
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25513701
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25453782
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24924179
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24127213
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15838136
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11342114
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11049165
28FOXP3_21729870_ChIP-Seq_TREG_Human2.11006432
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03305186
30GABP_19822575_ChIP-Seq_HepG2_Human1.97482631
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95391145
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87144912
33DCP1A_22483619_ChIP-Seq_HELA_Human1.86362857
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85375620
35VDR_22108803_ChIP-Seq_LS180_Human1.79195307
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79072918
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.71374350
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69495014
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64991155
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62078611
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61181049
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.57635065
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55608651
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55005004
45IGF1R_20145208_ChIP-Seq_DFB_Human1.54531429
46TTF2_22483619_ChIP-Seq_HELA_Human1.51900068
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51240687
48XRN2_22483619_ChIP-Seq_HELA_Human1.51071453
49MYC_18940864_ChIP-ChIP_HL60_Human1.46703573
50ZNF274_21170338_ChIP-Seq_K562_Hela1.44543919
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38868346
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38649778
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.35453741
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34296912
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30917245
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28552608
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26098661
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25554792
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25234047
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24220765
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22321448
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20812554
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14465529
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09229692
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08781207
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04725588
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04182086
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03112637
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02740802
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01364350
71TP53_22573176_ChIP-Seq_HFKS_Human0.97166208
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97000297
73PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94841068
74ELF5_23300383_ChIP-Seq_T47D_Human0.94810482
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94559394
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91640702
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90819958
78IRF1_19129219_ChIP-ChIP_H3396_Human0.88785123
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87864799
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87791339
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87687480
82BP1_19119308_ChIP-ChIP_Hs578T_Human0.86478568
83RXR_22158963_ChIP-Seq_LIVER_Mouse0.85200095
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.84485341
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81271163
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81106378
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80837251
88FLI1_27457419_Chip-Seq_LIVER_Mouse0.77917673
89GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77520713
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76631092
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76579193
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75024569
93ERG_20517297_ChIP-Seq_VCAP_Human0.74447438
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74102663
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.74021082
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72621254
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72081483
98CSB_26484114_Chip-Seq_FIBROBLAST_Human0.72045099
99GATA3_26560356_Chip-Seq_TH2_Human0.71119156
100EWS_26573619_Chip-Seq_HEK293_Human0.70512710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.64575440
2MP0002139_abnormal_hepatobiliary_system4.38209489
3MP0003195_calcinosis3.60555510
4MP0002163_abnormal_gland_morphology3.33292171
5MP0002876_abnormal_thyroid_physiology3.30088215
6MP0003693_abnormal_embryo_hatching3.26784481
7MP0009697_abnormal_copulation3.25772765
8MP0005360_urolithiasis3.25137693
9MP0008875_abnormal_xenobiotic_pharmacok3.08069044
10MP0008058_abnormal_DNA_repair2.86033325
11MP0005084_abnormal_gallbladder_morpholo2.83377536
12MP0003806_abnormal_nucleotide_metabolis2.78246348
13MP0003186_abnormal_redox_activity2.45835523
14MP0008789_abnormal_olfactory_epithelium2.36031266
15MP0004957_abnormal_blastocyst_morpholog2.28079601
16MP0005085_abnormal_gallbladder_physiolo2.24752897
17MP0001764_abnormal_homeostasis2.20823011
18MP0003950_abnormal_plasma_membrane2.17337503
19MP0001529_abnormal_vocalization2.16320135
20MP0005379_endocrine/exocrine_gland_phen2.05243661
21MP0003252_abnormal_bile_duct2.04158460
22MP0001661_extended_life_span1.94402361
23MP0010094_abnormal_chromosome_stability1.85732705
24MP0005332_abnormal_amino_acid1.84116185
25MP0009333_abnormal_splenocyte_physiolog1.75674237
26MP0005645_abnormal_hypothalamus_physiol1.72459988
27MP0001919_abnormal_reproductive_system1.72098646
28MP0005499_abnormal_olfactory_system1.70683070
29MP0005394_taste/olfaction_phenotype1.70683070
30MP0005671_abnormal_response_to1.65629668
31MP0003718_maternal_effect1.62288654
32MP0003868_abnormal_feces_composition1.62125943
33MP0005365_abnormal_bile_salt1.59818912
34MP0005167_abnormal_blood-brain_barrier1.55446399
35MP0005377_hearing/vestibular/ear_phenot1.48404173
36MP0003878_abnormal_ear_physiology1.48404173
37MP0006036_abnormal_mitochondrial_physio1.44679048
38MP0008932_abnormal_embryonic_tissue1.40108382
39MP0002148_abnormal_hypersensitivity_rea1.39003101
40MP0002277_abnormal_respiratory_mucosa1.38386850
41MP0008872_abnormal_physiological_respon1.37461750
42MP0003786_premature_aging1.27351117
43MP0000465_gastrointestinal_hemorrhage1.25401388
44MP0005253_abnormal_eye_physiology1.23353334
45MP0001485_abnormal_pinna_reflex1.22150035
46MP0000490_abnormal_crypts_of1.17798715
47MP0001984_abnormal_olfaction1.17793888
48MP0005389_reproductive_system_phenotype1.15454951
49MP0008877_abnormal_DNA_methylation1.08300019
50MP0006035_abnormal_mitochondrial_morpho1.03291527
51MP0005636_abnormal_mineral_homeostasis1.00948503
52MP0010386_abnormal_urinary_bladder1.00835522
53MP0001849_ear_inflammation1.00832200
54MP0003763_abnormal_thymus_physiology1.00592060
55MP0003011_delayed_dark_adaptation0.99139116
56MP0003221_abnormal_cardiomyocyte_apopto0.97586765
57MP0005408_hypopigmentation0.91558845
58MP0003111_abnormal_nucleus_morphology0.90483689
59MP0005220_abnormal_exocrine_pancreas0.87992408
60MP0004084_abnormal_cardiac_muscle0.87564027
61MP0005083_abnormal_biliary_tract0.84857014
62MP0006072_abnormal_retinal_apoptosis0.83958060
63MP0002102_abnormal_ear_morphology0.83686839
64MP0005319_abnormal_enzyme/_coenzyme0.80801047
65MP0005410_abnormal_fertilization0.79894297
66MP0000427_abnormal_hair_cycle0.79179035
67MP0004147_increased_porphyrin_level0.78448184
68MP0000647_abnormal_sebaceous_gland0.75034683
69MP0003077_abnormal_cell_cycle0.74081643
70MP0010329_abnormal_lipoprotein_level0.73753807
71MP0005187_abnormal_penis_morphology0.73458497
72MP0001727_abnormal_embryo_implantation0.72606057
73MP0005551_abnormal_eye_electrophysiolog0.72023508
74MP0000609_abnormal_liver_physiology0.70335352
75MP0005330_cardiomyopathy0.70317360
76MP0005584_abnormal_enzyme/coenzyme_acti0.69559548
77MP0002090_abnormal_vision0.66782760
78MP0002723_abnormal_immune_serum0.66759692
79MP0001853_heart_inflammation0.66380562
80MP0005395_other_phenotype0.66124435
81MP0002909_abnormal_adrenal_gland0.63711465
82MP0002938_white_spotting0.62354680
83MP0010234_abnormal_vibrissa_follicle0.62334978
84MP0001790_abnormal_immune_system0.60757642
85MP0005387_immune_system_phenotype0.60757642
86MP0004782_abnormal_surfactant_physiolog0.60311600
87MP0009643_abnormal_urine_homeostasis0.59877081
88MP0008057_abnormal_DNA_replication0.59843747
89MP0001348_abnormal_lacrimal_gland0.59055878
90MP0000358_abnormal_cell_content/0.58630554
91MP0003941_abnormal_skin_development0.57925744
92MP0001346_abnormal_lacrimal_gland0.57728288
93MP0004742_abnormal_vestibular_system0.57643035
94MP0008007_abnormal_cellular_replicative0.56950637
95MP0001666_abnormal_nutrient_absorption0.56748981
96MP0002019_abnormal_tumor_incidence0.56449229
97MP0002160_abnormal_reproductive_system0.56056185
98MP0000685_abnormal_immune_system0.55942469
99MP0002210_abnormal_sex_determination0.55703078
100MP0008469_abnormal_protein_level0.54844400

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.84426037
2Abnormality of glycolysis (HP:0004366)5.35507293
3Abnormal gallbladder physiology (HP:0012438)4.68532917
4Cholecystitis (HP:0001082)4.68532917
5Acute necrotizing encephalopathy (HP:0006965)4.36284194
6Oral leukoplakia (HP:0002745)4.27185201
7Increased CSF lactate (HP:0002490)4.21556218
8Hepatocellular necrosis (HP:0001404)4.17655505
9Mitochondrial inheritance (HP:0001427)4.08507030
10Acute encephalopathy (HP:0006846)4.00002649
11Abnormal mitochondria in muscle tissue (HP:0008316)3.94065049
12Hepatic necrosis (HP:0002605)3.79716675
13Cerebral edema (HP:0002181)3.68059521
14Reduced antithrombin III activity (HP:0001976)3.55083155
15Progressive macrocephaly (HP:0004481)3.51879410
16Abnormality of alanine metabolism (HP:0010916)3.50857699
17Hyperalaninemia (HP:0003348)3.50857699
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50857699
19Increased serum lactate (HP:0002151)3.20793149
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.12458154
21Deep venous thrombosis (HP:0002625)3.07373156
22Opisthotonus (HP:0002179)3.04309657
23Abnormality of the pons (HP:0007361)2.93736950
24Hypoplasia of the pons (HP:0012110)2.89823785
25Entropion (HP:0000621)2.88392044
263-Methylglutaconic aciduria (HP:0003535)2.86800265
27Hypoproteinemia (HP:0003075)2.78712373
28Lipid accumulation in hepatocytes (HP:0006561)2.74488685
29Leukodystrophy (HP:0002415)2.74193919
30Prolonged partial thromboplastin time (HP:0003645)2.71115226
31Dyschromatopsia (HP:0007641)2.69616412
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.66177205
33Cutaneous melanoma (HP:0012056)2.64899494
34Increased hepatocellular lipid droplets (HP:0006565)2.63305575
35Increased intramyocellular lipid droplets (HP:0012240)2.62999907
36Cerebral palsy (HP:0100021)2.59666865
37Hypobetalipoproteinemia (HP:0003563)2.56602138
38Abnormality of placental membranes (HP:0011409)2.54317269
39Amniotic constriction ring (HP:0009775)2.54317269
40Palpitations (HP:0001962)2.52797960
41Lactic acidosis (HP:0003128)2.51123193
42Methylmalonic acidemia (HP:0002912)2.50673463
43Respiratory failure (HP:0002878)2.50181624
44Abnormality of methionine metabolism (HP:0010901)2.48453248
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44141495
46Abnormal biliary tract physiology (HP:0012439)2.43828128
47Bile duct proliferation (HP:0001408)2.43828128
48Methylmalonic aciduria (HP:0012120)2.38748804
49Microvesicular hepatic steatosis (HP:0001414)2.38318296
50Lethargy (HP:0001254)2.37572006
51Aplastic anemia (HP:0001915)2.34827003
52Increased muscle lipid content (HP:0009058)2.33045956
53Intrahepatic cholestasis (HP:0001406)2.31635241
54Exercise intolerance (HP:0003546)2.31434150
55Abnormality of pyrimidine metabolism (HP:0004353)2.26012373
56Sparse eyelashes (HP:0000653)2.24994184
57CNS demyelination (HP:0007305)2.24929949
58Abnormality of fatty-acid metabolism (HP:0004359)2.24843931
59Spastic paraparesis (HP:0002313)2.23538581
60Type I transferrin isoform profile (HP:0003642)2.18733681
61CNS hypomyelination (HP:0003429)2.17033981
62Abnormality of serum amino acid levels (HP:0003112)2.16681223
63Rough bone trabeculation (HP:0100670)2.16654689
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09933642
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09933642
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07863971
67Dicarboxylic aciduria (HP:0003215)2.07863971
68Renal Fanconi syndrome (HP:0001994)2.06451698
69Optic disc pallor (HP:0000543)2.04502884
70Hyperglycinemia (HP:0002154)2.03783229
71Testicular atrophy (HP:0000029)2.03137854
72Generalized aminoaciduria (HP:0002909)2.02032972
73Rhabdomyolysis (HP:0003201)1.99563464
74Prominent metopic ridge (HP:0005487)1.98709954
75Hemiplegia (HP:0002301)1.96445175
76Cerebral hypomyelination (HP:0006808)1.95273536
77Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91812423
78Metabolic acidosis (HP:0001942)1.89440491
79Abnormality of urine glucose concentration (HP:0011016)1.87556294
80Glycosuria (HP:0003076)1.87556294
81Abnormality of sulfur amino acid metabolism (HP:0004339)1.85904086
82Cholelithiasis (HP:0001081)1.85725725
83Type 2 muscle fiber atrophy (HP:0003554)1.85476104
84Abnormality of the metopic suture (HP:0005556)1.85112616
85Respiratory difficulties (HP:0002880)1.84239377
86Emotional lability (HP:0000712)1.83910140
87Vacuolated lymphocytes (HP:0001922)1.82922542
88Hyperammonemia (HP:0001987)1.80137161
89Inability to walk (HP:0002540)1.77889961
90Renal cortical cysts (HP:0000803)1.77278466
91Parakeratosis (HP:0001036)1.75265607
92Abnormal gallbladder morphology (HP:0012437)1.74662329
93Abnormality of nucleobase metabolism (HP:0010932)1.74434543
94Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73037732
95Abnormality of the labia minora (HP:0012880)1.70742999
96Muscle fiber atrophy (HP:0100295)1.70304796
97Abnormality of T cell number (HP:0011839)1.68680356
98Reduced subcutaneous adipose tissue (HP:0003758)1.68430882
99Renal tubular dysfunction (HP:0000124)1.67402323
100Myoglobinuria (HP:0002913)1.67341707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK17.27950835
2VRK24.20040610
3TSSK63.73323402
4CCNB13.42673159
5TLK13.40639222
6ZAK3.34991737
7DAPK22.87506718
8VRK12.66790844
9BUB12.65644415
10NME12.41426085
11MAP4K22.29797302
12MST42.27680510
13MUSK2.13806801
14TAF11.80963938
15INSRR1.72123545
16CDC71.67044149
17PIK3CG1.66186227
18IRAK31.56989965
19PBK1.50052061
20SRPK11.39379216
21BCR1.36666706
22EIF2AK11.31267201
23BCKDK1.27107535
24ADRBK21.23269747
25NUAK11.16339840
26DAPK31.15518533
27WNK41.14280182
28MAP3K111.08042675
29PIM21.06836015
30PLK31.06543138
31SCYL21.02357204
32LMTK21.01825000
33RPS6KA50.99577420
34GRK10.96699973
35EIF2AK30.96103770
36CSNK1A1L0.96055267
37CDK80.93587879
38CSNK1G30.92945695
39TESK20.91211906
40STK390.84715213
41CSNK1G20.84225335
42AURKA0.84052336
43PLK20.83874683
44BRSK10.82259935
45FGFR10.78613073
46CAMKK20.78274653
47LIMK10.77850360
48CSNK1G10.77671413
49DYRK20.73342526
50DAPK10.73019487
51AURKB0.71809400
52PDK20.70707160
53PAK40.68903047
54STK160.68193675
55ALK0.67693887
56MAP3K60.64140415
57MAP2K70.57089723
58GRK60.55254906
59TXK0.54412554
60TRIM280.53399073
61TAOK10.51102591
62ARAF0.50911311
63GRK50.50528392
64OXSR10.50008246
65PLK10.49610966
66BLK0.48640006
67IKBKB0.46878632
68FRK0.45600976
69PHKG20.44930096
70PHKG10.44930096
71AKT20.44108893
72RPS6KB20.43444212
73PRKCI0.41809134
74CSNK2A20.40895789
75CSNK2A10.40647987
76CLK10.38524138
77MAPKAPK30.37443492
78PRKCQ0.36326013
79MAP3K120.35787323
80TESK10.34945854
81ATR0.34869008
82PKN10.32782846
83PIM10.32514850
84IKBKE0.32486529
85MST1R0.28180159
86CHEK10.26507367
87NME20.25459414
88STK40.23805010
89ILK0.23473113
90MYLK0.21643212
91PLK40.21432389
92CASK0.21226043
93EIF2AK20.21174844
94FER0.20679406
95OBSCN0.20632912
96GRK70.20609894
97CDK90.20053001
98PASK0.19453918
99PRKCG0.18781366
100TAOK30.18509394

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42328502
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88811512
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.81357412
4One carbon pool by folate_Homo sapiens_hsa006702.78013999
5Oxidative phosphorylation_Homo sapiens_hsa001902.50944590
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45858667
7RNA polymerase_Homo sapiens_hsa030202.25798886
8Parkinsons disease_Homo sapiens_hsa050122.25321871
9Sulfur metabolism_Homo sapiens_hsa009202.19736857
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13674853
11Steroid biosynthesis_Homo sapiens_hsa001002.09498558
12Systemic lupus erythematosus_Homo sapiens_hsa053222.08622688
13Protein export_Homo sapiens_hsa030602.07553109
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07001856
15Pyruvate metabolism_Homo sapiens_hsa006201.95954390
16Propanoate metabolism_Homo sapiens_hsa006401.89110051
17RNA degradation_Homo sapiens_hsa030181.85923106
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78876655
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74719385
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70664826
21Non-homologous end-joining_Homo sapiens_hsa034501.69258489
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61357935
23DNA replication_Homo sapiens_hsa030301.61046928
24Peroxisome_Homo sapiens_hsa041461.60331561
25Huntingtons disease_Homo sapiens_hsa050161.54730876
26Mismatch repair_Homo sapiens_hsa034301.45371280
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44534016
28RNA transport_Homo sapiens_hsa030131.44106383
29Carbon metabolism_Homo sapiens_hsa012001.42307759
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42288077
31Alzheimers disease_Homo sapiens_hsa050101.40094430
32Base excision repair_Homo sapiens_hsa034101.36071945
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35455265
34Pyrimidine metabolism_Homo sapiens_hsa002401.33796661
35Spliceosome_Homo sapiens_hsa030401.32012273
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.29484378
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29180213
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27392811
39Nucleotide excision repair_Homo sapiens_hsa034201.26459776
40Alcoholism_Homo sapiens_hsa050341.24945122
41Butanoate metabolism_Homo sapiens_hsa006501.21993395
42Biosynthesis of amino acids_Homo sapiens_hsa012301.18411462
43Sulfur relay system_Homo sapiens_hsa041221.17279932
44Fatty acid elongation_Homo sapiens_hsa000621.12545858
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11718386
46Homologous recombination_Homo sapiens_hsa034401.08838175
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07612113
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06994692
49Folate biosynthesis_Homo sapiens_hsa007901.00877526
50Arginine and proline metabolism_Homo sapiens_hsa003300.98028384
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96999992
52Arginine biosynthesis_Homo sapiens_hsa002200.95984175
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94301877
54Ribosome_Homo sapiens_hsa030100.94274242
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92858076
56Fatty acid metabolism_Homo sapiens_hsa012120.91208399
57Basal transcription factors_Homo sapiens_hsa030220.91038295
58Phenylalanine metabolism_Homo sapiens_hsa003600.90959997
59Purine metabolism_Homo sapiens_hsa002300.90649871
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.84939325
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82387091
62Complement and coagulation cascades_Homo sapiens_hsa046100.81954124
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79699312
64Metabolic pathways_Homo sapiens_hsa011000.77907594
65Retinol metabolism_Homo sapiens_hsa008300.77894660
66Fanconi anemia pathway_Homo sapiens_hsa034600.77072534
67beta-Alanine metabolism_Homo sapiens_hsa004100.76775216
68Chemical carcinogenesis_Homo sapiens_hsa052040.75071469
69Fatty acid biosynthesis_Homo sapiens_hsa000610.74534947
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.74345575
71Fatty acid degradation_Homo sapiens_hsa000710.71997490
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.71784162
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71430281
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.71119349
75Tryptophan metabolism_Homo sapiens_hsa003800.70481413
76Glutathione metabolism_Homo sapiens_hsa004800.70063885
77Linoleic acid metabolism_Homo sapiens_hsa005910.66607944
78Nitrogen metabolism_Homo sapiens_hsa009100.66379684
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64715911
80Antigen processing and presentation_Homo sapiens_hsa046120.60697436
81Caffeine metabolism_Homo sapiens_hsa002320.55887232
82Viral carcinogenesis_Homo sapiens_hsa052030.52034707
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48268644
84Primary immunodeficiency_Homo sapiens_hsa053400.45565945
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.43333886
86Vibrio cholerae infection_Homo sapiens_hsa051100.43063259
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42468036
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.39115872
89Ether lipid metabolism_Homo sapiens_hsa005650.37685092
90Fat digestion and absorption_Homo sapiens_hsa049750.37380129
91N-Glycan biosynthesis_Homo sapiens_hsa005100.36672881
92Cell cycle_Homo sapiens_hsa041100.35071429
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34458110
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33383554
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27423325
96Cardiac muscle contraction_Homo sapiens_hsa042600.27010835
97Collecting duct acid secretion_Homo sapiens_hsa049660.26997052
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26708904
99Prion diseases_Homo sapiens_hsa050200.24242173
100Starch and sucrose metabolism_Homo sapiens_hsa005000.23999866

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