VDAC1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cytokine production involved in inflammatory response (GO:1900015)8.25535808
2DNA double-strand break processing (GO:0000729)6.24555155
3regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.07400160
4negative regulation of thymocyte apoptotic process (GO:0070244)4.89784198
5regulation of interleukin-6 biosynthetic process (GO:0045408)4.83191452
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.72251970
7regulation of mitotic spindle checkpoint (GO:1903504)4.72251970
8DNA catabolic process, exonucleolytic (GO:0000738)4.26690895
9DNA strand renaturation (GO:0000733)4.24771203
10microtubule depolymerization (GO:0007019)4.16889872
11lactate metabolic process (GO:0006089)4.16080547
12rRNA methylation (GO:0031167)4.13227144
13positive regulation of transcription regulatory region DNA binding (GO:2000679)4.12754881
14DNA deamination (GO:0045006)4.08277431
15rRNA modification (GO:0000154)4.08235959
16signal peptide processing (GO:0006465)3.97121446
17retinal cone cell development (GO:0046549)3.93853361
18activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.82728755
19regulation of immunoglobulin secretion (GO:0051023)3.78061181
20parturition (GO:0007567)3.73675926
21regulation of interleukin-8 biosynthetic process (GO:0045414)3.72523654
22positive regulation of cell cycle checkpoint (GO:1901978)3.68727134
23DNA damage response, detection of DNA damage (GO:0042769)3.59285184
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54319219
25postreplication repair (GO:0006301)3.50145214
26positive regulation of osteoclast differentiation (GO:0045672)3.50009409
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44107175
28chromatin remodeling at centromere (GO:0031055)3.43390841
29CENP-A containing nucleosome assembly (GO:0034080)3.41107879
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40360662
31cytokine biosynthetic process (GO:0042089)3.36148851
32inner mitochondrial membrane organization (GO:0007007)3.27227160
33telomere maintenance via semi-conservative replication (GO:0032201)3.25720536
34recombinational repair (GO:0000725)3.18412942
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17562140
36negative regulation of DNA recombination (GO:0045910)3.16725585
37regulation of helicase activity (GO:0051095)3.15837082
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15669827
39regulation of thymocyte apoptotic process (GO:0070243)3.15188569
40regulation of spindle checkpoint (GO:0090231)3.14568237
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13588900
42double-strand break repair via homologous recombination (GO:0000724)3.12087525
43regulation of cellular amino acid metabolic process (GO:0006521)3.10707530
44telomere maintenance via recombination (GO:0000722)3.09866258
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09375930
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08459965
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08459965
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08459965
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.08234901
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.08234901
51isotype switching (GO:0045190)3.08234901
52replication fork processing (GO:0031297)3.08132915
53protein complex biogenesis (GO:0070271)3.08022209
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04227461
55mitochondrial respiratory chain complex assembly (GO:0033108)3.02246857
56signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01969436
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01969436
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.01806554
59regulation of interleukin-12 biosynthetic process (GO:0045075)3.00897427
60protein neddylation (GO:0045116)3.00597029
61DNA ligation (GO:0006266)3.00029700
62signal transduction involved in cell cycle checkpoint (GO:0072395)2.99109882
63signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98656145
64signal transduction involved in DNA damage checkpoint (GO:0072422)2.98656145
65negative regulation of ligase activity (GO:0051352)2.96750922
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96750922
67DNA strand elongation involved in DNA replication (GO:0006271)2.95162036
68retinal rod cell development (GO:0046548)2.94826503
69histone H2A acetylation (GO:0043968)2.92929575
70pseudouridine synthesis (GO:0001522)2.88285184
71mitotic recombination (GO:0006312)2.88226886
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.84672596
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84672596
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.84169268
75NADH dehydrogenase complex assembly (GO:0010257)2.84169268
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84169268
77ether lipid metabolic process (GO:0046485)2.83131525
78establishment of integrated proviral latency (GO:0075713)2.80361264
79regulation of interleukin-2 biosynthetic process (GO:0045076)2.80294863
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.78621437
81negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.77640230
82spindle assembly involved in mitosis (GO:0090307)2.77239181
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76519701
84respiratory chain complex IV assembly (GO:0008535)2.75189847
85GMP metabolic process (GO:0046037)2.74136832
86histone exchange (GO:0043486)2.72974635
87piRNA metabolic process (GO:0034587)2.72039664
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70760028
89detection of light stimulus involved in sensory perception (GO:0050962)2.68530095
90detection of light stimulus involved in visual perception (GO:0050908)2.68530095
91cytokine metabolic process (GO:0042107)2.67337824
92positive regulation of ligase activity (GO:0051351)2.66823966
93DNA strand elongation (GO:0022616)2.66637592
94water-soluble vitamin biosynthetic process (GO:0042364)2.66042920
95protein localization to kinetochore (GO:0034501)2.64849137
96negative regulation of telomere maintenance (GO:0032205)2.64717643
97aldehyde catabolic process (GO:0046185)2.62786568
98L-fucose catabolic process (GO:0042355)2.62785066
99fucose catabolic process (GO:0019317)2.62785066
100L-fucose metabolic process (GO:0042354)2.62785066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.40221483
2FLI1_27457419_Chip-Seq_LIVER_Mouse3.89487002
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64660179
4E2F7_22180533_ChIP-Seq_HELA_Human3.57742929
5ZNF274_21170338_ChIP-Seq_K562_Hela3.52138235
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.35873920
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05297897
8PCGF2_27294783_Chip-Seq_ESCs_Mouse3.02848586
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93589765
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.77063095
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73567710
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66789512
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40157775
14ELK1_19687146_ChIP-ChIP_HELA_Human2.34369014
15IGF1R_20145208_ChIP-Seq_DFB_Human2.29625775
16IRF1_19129219_ChIP-ChIP_H3396_Human2.27715010
17VDR_23849224_ChIP-Seq_CD4+_Human2.25512407
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10985481
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05457547
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03865274
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.03520585
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.99428826
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96088373
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91531844
25FOXP3_21729870_ChIP-Seq_TREG_Human1.84551540
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83219977
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81453608
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.75959902
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75539928
30EWS_26573619_Chip-Seq_HEK293_Human1.74065300
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69170766
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67306361
33FUS_26573619_Chip-Seq_HEK293_Human1.67030095
34VDR_22108803_ChIP-Seq_LS180_Human1.66318225
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.66304160
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64778125
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.60784641
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57640421
39MYC_18940864_ChIP-ChIP_HL60_Human1.55243668
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54581311
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43018785
42DCP1A_22483619_ChIP-Seq_HELA_Human1.42094230
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.41068023
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38692635
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38296832
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.37922916
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36546752
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35247123
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.34892712
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30552915
51TTF2_22483619_ChIP-Seq_HELA_Human1.30200739
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29456751
53P53_22387025_ChIP-Seq_ESCs_Mouse1.29248549
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28460167
55P300_19829295_ChIP-Seq_ESCs_Human1.27133293
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.23033171
57P300_18555785_Chip-Seq_ESCs_Mouse1.22306473
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21913705
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.20539213
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.20515656
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.19758190
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.19664753
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.19137703
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19006086
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18590922
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.18290462
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.17823274
68CTCF_18555785_Chip-Seq_ESCs_Mouse1.17454341
69SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17195513
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.15866048
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15866048
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.14469040
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.13715442
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12386396
75HTT_18923047_ChIP-ChIP_STHdh_Human1.09376621
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09259165
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08811744
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07867160
79ETV1_20927104_ChIP-Seq_GIST48_Human1.06400001
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06372998
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.06077959
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05230104
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04824860
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03603804
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03119839
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01895466
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01742631
88NFYB_21822215_ChIP-Seq_K562_Human1.01402330
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.01275655
90PU1_27457419_Chip-Seq_LIVER_Mouse1.01095304
91PHF8_20622853_ChIP-Seq_HELA_Human1.01071344
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00913359
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00807823
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00611773
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.00067138
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99875245
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99842821
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98616613
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98518971
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98514253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.06493291
2MP0003806_abnormal_nucleotide_metabolis2.67817966
3MP0009785_altered_susceptibility_to2.47705396
4MP0010094_abnormal_chromosome_stability2.47502229
5MP0008875_abnormal_xenobiotic_pharmacok2.46821849
6MP0001790_abnormal_immune_system2.45951610
7MP0005387_immune_system_phenotype2.45951610
8MP0006292_abnormal_olfactory_placode2.40901362
9MP0001849_ear_inflammation2.22878752
10MP0005253_abnormal_eye_physiology2.16851146
11MP0005671_abnormal_response_to2.15558280
12MP0002933_joint_inflammation2.12244383
13MP0003693_abnormal_embryo_hatching2.10445386
14MP0002163_abnormal_gland_morphology2.09362565
15MP0002638_abnormal_pupillary_reflex2.08714940
16MP0005551_abnormal_eye_electrophysiolog2.07544203
17MP0005187_abnormal_penis_morphology2.05015258
18MP0004215_abnormal_myocardial_fiber2.03850415
19MP0006072_abnormal_retinal_apoptosis2.02040640
20MP0001661_extended_life_span1.91005957
21MP0008058_abnormal_DNA_repair1.89629484
22MP0002822_catalepsy1.83064712
23MP0005084_abnormal_gallbladder_morpholo1.72075524
24MP0010155_abnormal_intestine_physiology1.71878978
25MP0003011_delayed_dark_adaptation1.71582017
26MP0005379_endocrine/exocrine_gland_phen1.70810583
27MP0000647_abnormal_sebaceous_gland1.69903888
28MP0001919_abnormal_reproductive_system1.68917626
29MP0003880_abnormal_central_pattern1.67020228
30MP0001873_stomach_inflammation1.61708236
31MP0003111_abnormal_nucleus_morphology1.60165789
32MP0008873_increased_physiological_sensi1.58098868
33MP0005645_abnormal_hypothalamus_physiol1.57876910
34MP0002095_abnormal_skin_pigmentation1.57614798
35MP0002938_white_spotting1.56592525
36MP0008877_abnormal_DNA_methylation1.54237481
37MP0008872_abnormal_physiological_respon1.53453767
38MP0001986_abnormal_taste_sensitivity1.51025669
39MP0006035_abnormal_mitochondrial_morpho1.45442556
40MP0002148_abnormal_hypersensitivity_rea1.43956940
41MP0000490_abnormal_crypts_of1.42374068
42MP0004957_abnormal_blastocyst_morpholog1.39139529
43MP0003567_abnormal_fetal_cardiomyocyte1.37176696
44MP0001764_abnormal_homeostasis1.36784409
45MP0001984_abnormal_olfaction1.34946392
46MP0000372_irregular_coat_pigmentation1.34811985
47MP0005171_absent_coat_pigmentation1.34083706
48MP0006036_abnormal_mitochondrial_physio1.27636036
49MP0008007_abnormal_cellular_replicative1.24017577
50MP0001835_abnormal_antigen_presentation1.21874841
51MP0004782_abnormal_surfactant_physiolog1.15718455
52MP0009333_abnormal_splenocyte_physiolog1.15301920
53MP0002396_abnormal_hematopoietic_system1.14254686
54MP0005389_reproductive_system_phenotype1.13587693
55MP0003077_abnormal_cell_cycle1.12769460
56MP0002876_abnormal_thyroid_physiology1.11093707
57MP0002282_abnormal_trachea_morphology1.10173595
58MP0001800_abnormal_humoral_immune1.09943983
59MP0001346_abnormal_lacrimal_gland1.07878082
60MP0008057_abnormal_DNA_replication1.07215733
61MP0003195_calcinosis1.03163554
62MP0003786_premature_aging1.02568564
63MP0008932_abnormal_embryonic_tissue0.99809000
64MP0005365_abnormal_bile_salt0.98961294
65MP0001293_anophthalmia0.98748423
66MP0004019_abnormal_vitamin_homeostasis0.97048214
67MP0005310_abnormal_salivary_gland0.96295244
68MP0001243_abnormal_dermal_layer0.95237306
69MP0001177_atelectasis0.92988886
70MP0002138_abnormal_hepatobiliary_system0.92055902
71MP0006276_abnormal_autonomic_nervous0.91467763
72MP0005410_abnormal_fertilization0.89134267
73MP0005195_abnormal_posterior_eye0.89012384
74MP0003936_abnormal_reproductive_system0.85516520
75MP0005391_vision/eye_phenotype0.82976891
76MP0003436_decreased_susceptibility_to0.82444338
77MP0003718_maternal_effect0.79445075
78MP0001929_abnormal_gametogenesis0.79440843
79MP0005386_behavior/neurological_phenoty0.79057636
80MP0004924_abnormal_behavior0.79057636
81MP0000653_abnormal_sex_gland0.78136198
82MP0009697_abnormal_copulation0.77470593
83MP0002723_abnormal_immune_serum0.77292260
84MP0000383_abnormal_hair_follicle0.76593020
85MP0005647_abnormal_sex_gland0.75634730
86MP0005319_abnormal_enzyme/_coenzyme0.72893804
87MP0000778_abnormal_nervous_system0.72820113
88MP0004147_increased_porphyrin_level0.72216081
89MP0003698_abnormal_male_reproductive0.71971024
90MP0002210_abnormal_sex_determination0.71882907
91MP0001145_abnormal_male_reproductive0.71167202
92MP0000358_abnormal_cell_content/0.69442124
93MP0003943_abnormal_hepatobiliary_system0.69015766
94MP0004484_altered_response_of0.68476119
95MP0002452_abnormal_antigen_presenting0.66546645
96MP0000703_abnormal_thymus_morphology0.64903982
97MP0002405_respiratory_system_inflammati0.64875824
98MP0002229_neurodegeneration0.63174848
99MP0002272_abnormal_nervous_system0.62954709
100MP0005085_abnormal_gallbladder_physiolo0.62887278

Predicted human phenotypes

RankGene SetZ-score
1Chronic mucocutaneous candidiasis (HP:0002728)4.85482256
2Recurrent cutaneous fungal infections (HP:0011370)4.85482256
3Increased hepatocellular lipid droplets (HP:0006565)3.89186728
4Lipid accumulation in hepatocytes (HP:0006561)3.80877345
5Submucous cleft hard palate (HP:0000176)3.56447497
6Central scotoma (HP:0000603)3.37786947
7Pendular nystagmus (HP:0012043)3.32797211
8Attenuation of retinal blood vessels (HP:0007843)3.01698927
9Entropion (HP:0000621)3.00955851
10Posterior subcapsular cataract (HP:0007787)2.91798401
11Mitochondrial inheritance (HP:0001427)2.83650930
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82274236
13Constricted visual fields (HP:0001133)2.81744270
14Carpal bone hypoplasia (HP:0001498)2.75516992
15Increased CSF lactate (HP:0002490)2.73602582
16Methylmalonic acidemia (HP:0002912)2.72734542
17Mesangial abnormality (HP:0001966)2.66739224
18Renal Fanconi syndrome (HP:0001994)2.66253883
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.63148491
20Decreased central vision (HP:0007663)2.62163792
21Acute necrotizing encephalopathy (HP:0006965)2.61846116
22Congenital, generalized hypertrichosis (HP:0004540)2.55153068
23Abnormality of chromosome stability (HP:0003220)2.51827629
24IgG deficiency (HP:0004315)2.51516092
25Congenital stationary night blindness (HP:0007642)2.49555441
26Abolished electroretinogram (ERG) (HP:0000550)2.46064544
27Hepatocellular necrosis (HP:0001404)2.43947995
28Cerebellar dysplasia (HP:0007033)2.43568319
29Scotoma (HP:0000575)2.43082733
30Severe combined immunodeficiency (HP:0004430)2.42625828
31Abnormality of macular pigmentation (HP:0008002)2.41740786
32Stomatitis (HP:0010280)2.41610583
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37502032
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37502032
35Increased intramyocellular lipid droplets (HP:0012240)2.36309579
36Glucose intolerance (HP:0000833)2.34481876
37Cheilitis (HP:0100825)2.31877838
38Increased serum pyruvate (HP:0003542)2.31712513
39Abnormality of T cell physiology (HP:0011840)2.29884366
40Meckel diverticulum (HP:0002245)2.29794965
41Medial flaring of the eyebrow (HP:0010747)2.25047871
42Thyroiditis (HP:0100646)2.20799670
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.19946552
44Abnormal mitochondria in muscle tissue (HP:0008316)2.17326890
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16029105
46Methylmalonic aciduria (HP:0012120)2.14205767
47Hepatic necrosis (HP:0002605)2.13202946
48Pancreatic islet-cell hyperplasia (HP:0004510)2.11997073
49Abnormality of the ileum (HP:0001549)2.09040091
50Optic disc pallor (HP:0000543)2.07738611
51Increased serum lactate (HP:0002151)2.07661290
52Colon cancer (HP:0003003)2.07493748
53Absent speech (HP:0001344)2.06708969
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.06535654
55Hypothermia (HP:0002045)2.05659392
56Exertional dyspnea (HP:0002875)2.04936249
57Increased muscle lipid content (HP:0009058)2.04421497
58Abnormal rod and cone electroretinograms (HP:0008323)2.03379530
59Pancreatic cysts (HP:0001737)2.02778552
60Abnormality of glycolysis (HP:0004366)2.02510149
61Acute encephalopathy (HP:0006846)2.02486361
62Nephrogenic diabetes insipidus (HP:0009806)2.02453400
63Renal cortical cysts (HP:0000803)2.01963292
64Increased IgM level (HP:0003496)2.01795117
65Progressive macrocephaly (HP:0004481)2.01654415
66Short 4th metacarpal (HP:0010044)2.00978196
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00978196
68Adactyly (HP:0009776)2.00010881
69Stillbirth (HP:0003826)1.97650099
70Combined immunodeficiency (HP:0005387)1.97618585
71Bony spicule pigmentary retinopathy (HP:0007737)1.97117142
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97098656
73Abnormal lung lobation (HP:0002101)1.96909081
74Intestinal atresia (HP:0011100)1.96600561
75Cerebral edema (HP:0002181)1.96037819
76Chronic diarrhea (HP:0002028)1.92463013
77Brittle hair (HP:0002299)1.92348487
78Postaxial foot polydactyly (HP:0001830)1.92011101
79Adrenal hypoplasia (HP:0000835)1.91134359
80Congenital primary aphakia (HP:0007707)1.90810884
81Chorioretinal atrophy (HP:0000533)1.85895593
82Severe muscular hypotonia (HP:0006829)1.82670302
83Panhypogammaglobulinemia (HP:0003139)1.81792109
84Type II lissencephaly (HP:0007260)1.81458500
85Gait imbalance (HP:0002141)1.80254278
86Keratoconjunctivitis (HP:0001096)1.79885423
87Median cleft lip (HP:0000161)1.79141105
88True hermaphroditism (HP:0010459)1.77514113
89Lactic acidosis (HP:0003128)1.77035141
90Hypoproteinemia (HP:0003075)1.76990954
91Clubbing of toes (HP:0100760)1.76617016
92Dyschromatopsia (HP:0007641)1.75860539
93Sloping forehead (HP:0000340)1.72914693
94Neuroendocrine neoplasm (HP:0100634)1.72593111
95Abnormality of renal resorption (HP:0011038)1.72477342
96Hypoplastic pelvis (HP:0008839)1.71396777
97Rhabdomyosarcoma (HP:0002859)1.71029371
98Abnormal protein glycosylation (HP:0012346)1.68732267
99Abnormal glycosylation (HP:0012345)1.68732267
100Abnormal protein N-linked glycosylation (HP:0012347)1.68732267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK17.04993663
2TSSK63.56221413
3ZAK3.26176410
4NUAK13.07418174
5VRK22.64308569
6EIF2AK32.63297989
7TLK12.55136883
8TXK2.46575299
9VRK12.43463987
10SRPK12.35606962
11PBK2.20103216
12TAF12.13893752
13BCKDK2.08400056
14PLK32.03351437
15BUB12.02033512
16ADRBK21.81559723
17TRIM281.81425121
18CSNK1G21.79102150
19MST41.72024731
20MAPK131.69366192
21BCR1.66004121
22GRK11.46507201
23CSNK1G31.45255120
24CCNB11.45064727
25TTK1.41519354
26MAP4K21.37961033
27WNK41.34802116
28MAP2K71.30483277
29CSNK1G11.29645845
30MAP3K41.28285395
31FLT31.22167529
32EIF2AK11.20888193
33CSNK1A1L1.16040765
34CLK10.99994533
35EPHA40.96485830
36ACVR1B0.95404866
37EIF2AK20.93016917
38STK38L0.90716850
39WEE10.87360425
40PLK40.86126366
41STK390.79809301
42STK240.78853858
43DYRK20.76967153
44STK160.76548808
45ATR0.76543055
46CDC70.76297964
47DAPK10.74423477
48PRKD30.74024773
49FRK0.73015611
50PLK10.71994536
51AURKA0.70702102
52CAMKK20.69417068
53WNK30.67947319
54PASK0.65534261
55OXSR10.65193541
56AURKB0.63885486
57DAPK20.62501017
58TIE10.59170126
59PNCK0.58297916
60MKNK10.58021856
61PLK20.56986378
62BRSK20.54771560
63UHMK10.49837014
64MAPKAPK50.48628586
65TAOK30.45918785
66MKNK20.45799702
67CDK70.44875271
68PRKCQ0.42521246
69DAPK30.39700906
70ATM0.39394506
71CSNK2A10.38714075
72TEC0.36039415
73GRK50.35667408
74ILK0.35118103
75INSRR0.34673806
76MAP3K50.34556047
77MINK10.34421154
78CDK30.34251233
79NEK20.34191036
80NME10.34066961
81PHKG20.33395929
82PHKG10.33395929
83CHEK10.32161321
84CHEK20.31895901
85CSF1R0.30117196
86CDK180.30012528
87KIT0.29950706
88RPS6KB10.29451974
89OBSCN0.28564781
90CSNK2A20.28244176
91MAP3K140.28213138
92CAMK2A0.27977069
93PRKCE0.27714334
94MAP2K60.27694832
95CSNK1D0.26341869
96STK30.26325698
97RPS6KB20.25939732
98MAP3K120.25814918
99CSNK1A10.25767178
100CDK150.24848789

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42851946
2Caffeine metabolism_Homo sapiens_hsa002323.90474181
3Protein export_Homo sapiens_hsa030603.34547119
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.87086848
5Mismatch repair_Homo sapiens_hsa034302.74757764
6DNA replication_Homo sapiens_hsa030302.72546710
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43496434
8Homologous recombination_Homo sapiens_hsa034402.40506327
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29898906
10Non-homologous end-joining_Homo sapiens_hsa034502.24185947
11Phototransduction_Homo sapiens_hsa047442.15426320
12Oxidative phosphorylation_Homo sapiens_hsa001902.09547120
13Parkinsons disease_Homo sapiens_hsa050122.08145041
14Propanoate metabolism_Homo sapiens_hsa006402.06571670
15Primary immunodeficiency_Homo sapiens_hsa053402.02981496
16Nucleotide excision repair_Homo sapiens_hsa034201.96209742
17Fanconi anemia pathway_Homo sapiens_hsa034601.91835191
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91287381
19Vitamin B6 metabolism_Homo sapiens_hsa007501.89780998
20Systemic lupus erythematosus_Homo sapiens_hsa053221.78531405
21Basal transcription factors_Homo sapiens_hsa030221.74781833
22RNA degradation_Homo sapiens_hsa030181.73214710
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72037228
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69494800
25One carbon pool by folate_Homo sapiens_hsa006701.66407837
26Spliceosome_Homo sapiens_hsa030401.45621661
27RNA transport_Homo sapiens_hsa030131.44707776
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41449769
29RNA polymerase_Homo sapiens_hsa030201.32166921
30Huntingtons disease_Homo sapiens_hsa050161.31349428
31Purine metabolism_Homo sapiens_hsa002301.25102895
32Base excision repair_Homo sapiens_hsa034101.19218041
33Pyrimidine metabolism_Homo sapiens_hsa002401.19155385
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16773145
35Alzheimers disease_Homo sapiens_hsa050101.16558571
36Steroid biosynthesis_Homo sapiens_hsa001001.15714169
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13906657
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.12945563
39Ribosome_Homo sapiens_hsa030101.12638915
40Alcoholism_Homo sapiens_hsa050341.06453471
41Nitrogen metabolism_Homo sapiens_hsa009101.02805979
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02693688
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98675351
44Allograft rejection_Homo sapiens_hsa053300.96325503
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.95168445
46Autoimmune thyroid disease_Homo sapiens_hsa053200.91778504
47Cell cycle_Homo sapiens_hsa041100.86568153
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84370776
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80986516
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79693743
51Sulfur metabolism_Homo sapiens_hsa009200.79601375
52Ether lipid metabolism_Homo sapiens_hsa005650.78973730
53Butanoate metabolism_Homo sapiens_hsa006500.78234924
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.76904782
55Peroxisome_Homo sapiens_hsa041460.75335104
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70435463
57Regulation of autophagy_Homo sapiens_hsa041400.69888155
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.69343595
59Metabolic pathways_Homo sapiens_hsa011000.66458845
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.66253718
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65487034
62mRNA surveillance pathway_Homo sapiens_hsa030150.64376591
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63888978
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63297856
65Measles_Homo sapiens_hsa051620.62295405
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62247364
67Carbon metabolism_Homo sapiens_hsa012000.60651501
68Rheumatoid arthritis_Homo sapiens_hsa053230.56655210
69Olfactory transduction_Homo sapiens_hsa047400.56485845
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55607158
71Type I diabetes mellitus_Homo sapiens_hsa049400.53215684
72Fatty acid elongation_Homo sapiens_hsa000620.51858463
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51511022
74Viral carcinogenesis_Homo sapiens_hsa052030.49623590
75Graft-versus-host disease_Homo sapiens_hsa053320.49279748
76Linoleic acid metabolism_Homo sapiens_hsa005910.48674224
77Pyruvate metabolism_Homo sapiens_hsa006200.48662439
78Biosynthesis of amino acids_Homo sapiens_hsa012300.45064056
79Epstein-Barr virus infection_Homo sapiens_hsa051690.44856190
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43849705
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42699827
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41539218
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41071450
84Antigen processing and presentation_Homo sapiens_hsa046120.40931599
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38665283
86Asthma_Homo sapiens_hsa053100.37093767
87Chemical carcinogenesis_Homo sapiens_hsa052040.36396220
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35861267
89Cardiac muscle contraction_Homo sapiens_hsa042600.34218922
90p53 signaling pathway_Homo sapiens_hsa041150.33782616
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33056264
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29396940
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28380733
94Folate biosynthesis_Homo sapiens_hsa007900.27510449
95Oocyte meiosis_Homo sapiens_hsa041140.25918031
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.24497358
97Arginine and proline metabolism_Homo sapiens_hsa003300.24318617
98Sulfur relay system_Homo sapiens_hsa041220.22611168
99Morphine addiction_Homo sapiens_hsa050320.22095711
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.21457395

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