

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of cytokine production involved in inflammatory response (GO:1900015) | 8.25535808 |
| 2 | DNA double-strand break processing (GO:0000729) | 6.24555155 |
| 3 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 5.07400160 |
| 4 | negative regulation of thymocyte apoptotic process (GO:0070244) | 4.89784198 |
| 5 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 4.83191452 |
| 6 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 4.72251970 |
| 7 | regulation of mitotic spindle checkpoint (GO:1903504) | 4.72251970 |
| 8 | DNA catabolic process, exonucleolytic (GO:0000738) | 4.26690895 |
| 9 | DNA strand renaturation (GO:0000733) | 4.24771203 |
| 10 | microtubule depolymerization (GO:0007019) | 4.16889872 |
| 11 | lactate metabolic process (GO:0006089) | 4.16080547 |
| 12 | rRNA methylation (GO:0031167) | 4.13227144 |
| 13 | positive regulation of transcription regulatory region DNA binding (GO:2000679) | 4.12754881 |
| 14 | DNA deamination (GO:0045006) | 4.08277431 |
| 15 | rRNA modification (GO:0000154) | 4.08235959 |
| 16 | signal peptide processing (GO:0006465) | 3.97121446 |
| 17 | retinal cone cell development (GO:0046549) | 3.93853361 |
| 18 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.82728755 |
| 19 | regulation of immunoglobulin secretion (GO:0051023) | 3.78061181 |
| 20 | parturition (GO:0007567) | 3.73675926 |
| 21 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.72523654 |
| 22 | positive regulation of cell cycle checkpoint (GO:1901978) | 3.68727134 |
| 23 | DNA damage response, detection of DNA damage (GO:0042769) | 3.59285184 |
| 24 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.54319219 |
| 25 | postreplication repair (GO:0006301) | 3.50145214 |
| 26 | positive regulation of osteoclast differentiation (GO:0045672) | 3.50009409 |
| 27 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.44107175 |
| 28 | chromatin remodeling at centromere (GO:0031055) | 3.43390841 |
| 29 | CENP-A containing nucleosome assembly (GO:0034080) | 3.41107879 |
| 30 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.40360662 |
| 31 | cytokine biosynthetic process (GO:0042089) | 3.36148851 |
| 32 | inner mitochondrial membrane organization (GO:0007007) | 3.27227160 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.25720536 |
| 34 | recombinational repair (GO:0000725) | 3.18412942 |
| 35 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.17562140 |
| 36 | negative regulation of DNA recombination (GO:0045910) | 3.16725585 |
| 37 | regulation of helicase activity (GO:0051095) | 3.15837082 |
| 38 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.15669827 |
| 39 | regulation of thymocyte apoptotic process (GO:0070243) | 3.15188569 |
| 40 | regulation of spindle checkpoint (GO:0090231) | 3.14568237 |
| 41 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.13588900 |
| 42 | double-strand break repair via homologous recombination (GO:0000724) | 3.12087525 |
| 43 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.10707530 |
| 44 | telomere maintenance via recombination (GO:0000722) | 3.09866258 |
| 45 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.09375930 |
| 46 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.08459965 |
| 47 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.08459965 |
| 48 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.08459965 |
| 49 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.08234901 |
| 50 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.08234901 |
| 51 | isotype switching (GO:0045190) | 3.08234901 |
| 52 | replication fork processing (GO:0031297) | 3.08132915 |
| 53 | protein complex biogenesis (GO:0070271) | 3.08022209 |
| 54 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.04227461 |
| 55 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.02246857 |
| 56 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.01969436 |
| 57 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.01969436 |
| 58 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.01806554 |
| 59 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.00897427 |
| 60 | protein neddylation (GO:0045116) | 3.00597029 |
| 61 | DNA ligation (GO:0006266) | 3.00029700 |
| 62 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.99109882 |
| 63 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.98656145 |
| 64 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.98656145 |
| 65 | negative regulation of ligase activity (GO:0051352) | 2.96750922 |
| 66 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.96750922 |
| 67 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.95162036 |
| 68 | retinal rod cell development (GO:0046548) | 2.94826503 |
| 69 | histone H2A acetylation (GO:0043968) | 2.92929575 |
| 70 | pseudouridine synthesis (GO:0001522) | 2.88285184 |
| 71 | mitotic recombination (GO:0006312) | 2.88226886 |
| 72 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.84672596 |
| 73 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.84672596 |
| 74 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.84169268 |
| 75 | NADH dehydrogenase complex assembly (GO:0010257) | 2.84169268 |
| 76 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.84169268 |
| 77 | ether lipid metabolic process (GO:0046485) | 2.83131525 |
| 78 | establishment of integrated proviral latency (GO:0075713) | 2.80361264 |
| 79 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.80294863 |
| 80 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.78621437 |
| 81 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 2.77640230 |
| 82 | spindle assembly involved in mitosis (GO:0090307) | 2.77239181 |
| 83 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.76519701 |
| 84 | respiratory chain complex IV assembly (GO:0008535) | 2.75189847 |
| 85 | GMP metabolic process (GO:0046037) | 2.74136832 |
| 86 | histone exchange (GO:0043486) | 2.72974635 |
| 87 | piRNA metabolic process (GO:0034587) | 2.72039664 |
| 88 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.70760028 |
| 89 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.68530095 |
| 90 | detection of light stimulus involved in visual perception (GO:0050908) | 2.68530095 |
| 91 | cytokine metabolic process (GO:0042107) | 2.67337824 |
| 92 | positive regulation of ligase activity (GO:0051351) | 2.66823966 |
| 93 | DNA strand elongation (GO:0022616) | 2.66637592 |
| 94 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.66042920 |
| 95 | protein localization to kinetochore (GO:0034501) | 2.64849137 |
| 96 | negative regulation of telomere maintenance (GO:0032205) | 2.64717643 |
| 97 | aldehyde catabolic process (GO:0046185) | 2.62786568 |
| 98 | L-fucose catabolic process (GO:0042355) | 2.62785066 |
| 99 | fucose catabolic process (GO:0019317) | 2.62785066 |
| 100 | L-fucose metabolic process (GO:0042354) | 2.62785066 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.40221483 |
| 2 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 3.89487002 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.64660179 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.57742929 |
| 5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.52138235 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.35873920 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.05297897 |
| 8 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 3.02848586 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.93589765 |
| 10 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.77063095 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.73567710 |
| 12 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.66789512 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.40157775 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.34369014 |
| 15 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.29625775 |
| 16 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.27715010 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.25512407 |
| 18 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.10985481 |
| 19 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.05457547 |
| 20 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 2.03865274 |
| 21 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.03520585 |
| 22 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.99428826 |
| 23 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.96088373 |
| 24 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.91531844 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.84551540 |
| 26 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.83219977 |
| 27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.81453608 |
| 28 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.75959902 |
| 29 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.75539928 |
| 30 | EWS_26573619_Chip-Seq_HEK293_Human | 1.74065300 |
| 31 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.69170766 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.67306361 |
| 33 | FUS_26573619_Chip-Seq_HEK293_Human | 1.67030095 |
| 34 | VDR_22108803_ChIP-Seq_LS180_Human | 1.66318225 |
| 35 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.66304160 |
| 36 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.64778125 |
| 37 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.60784641 |
| 38 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.57640421 |
| 39 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.55243668 |
| 40 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.54581311 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.43018785 |
| 42 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.42094230 |
| 43 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.41068023 |
| 44 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.38692635 |
| 45 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.38296832 |
| 46 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.37922916 |
| 47 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.36546752 |
| 48 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.35247123 |
| 49 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.34892712 |
| 50 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.30552915 |
| 51 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.30200739 |
| 52 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.29456751 |
| 53 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.29248549 |
| 54 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.28460167 |
| 55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.27133293 |
| 56 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.23033171 |
| 57 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.22306473 |
| 58 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.21913705 |
| 59 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.20539213 |
| 60 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.20515656 |
| 61 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.19758190 |
| 62 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.19664753 |
| 63 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.19137703 |
| 64 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.19006086 |
| 65 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.18590922 |
| 66 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.18290462 |
| 67 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.17823274 |
| 68 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 1.17454341 |
| 69 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 1.17195513 |
| 70 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.15866048 |
| 71 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.15866048 |
| 72 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.14469040 |
| 73 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 1.13715442 |
| 74 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.12386396 |
| 75 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.09376621 |
| 76 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.09259165 |
| 77 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08811744 |
| 78 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.07867160 |
| 79 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.06400001 |
| 80 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.06372998 |
| 81 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.06077959 |
| 82 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.05230104 |
| 83 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.04824860 |
| 84 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.03603804 |
| 85 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.03119839 |
| 86 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.01895466 |
| 87 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01742631 |
| 88 | NFYB_21822215_ChIP-Seq_K562_Human | 1.01402330 |
| 89 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.01275655 |
| 90 | PU1_27457419_Chip-Seq_LIVER_Mouse | 1.01095304 |
| 91 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.01071344 |
| 92 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.00913359 |
| 93 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.00807823 |
| 94 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.00611773 |
| 95 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 1.00067138 |
| 96 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.99875245 |
| 97 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99842821 |
| 98 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.98616613 |
| 99 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.98518971 |
| 100 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.98514253 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001529_abnormal_vocalization | 3.06493291 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 2.67817966 |
| 3 | MP0009785_altered_susceptibility_to | 2.47705396 |
| 4 | MP0010094_abnormal_chromosome_stability | 2.47502229 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 2.46821849 |
| 6 | MP0001790_abnormal_immune_system | 2.45951610 |
| 7 | MP0005387_immune_system_phenotype | 2.45951610 |
| 8 | MP0006292_abnormal_olfactory_placode | 2.40901362 |
| 9 | MP0001849_ear_inflammation | 2.22878752 |
| 10 | MP0005253_abnormal_eye_physiology | 2.16851146 |
| 11 | MP0005671_abnormal_response_to | 2.15558280 |
| 12 | MP0002933_joint_inflammation | 2.12244383 |
| 13 | MP0003693_abnormal_embryo_hatching | 2.10445386 |
| 14 | MP0002163_abnormal_gland_morphology | 2.09362565 |
| 15 | MP0002638_abnormal_pupillary_reflex | 2.08714940 |
| 16 | MP0005551_abnormal_eye_electrophysiolog | 2.07544203 |
| 17 | MP0005187_abnormal_penis_morphology | 2.05015258 |
| 18 | MP0004215_abnormal_myocardial_fiber | 2.03850415 |
| 19 | MP0006072_abnormal_retinal_apoptosis | 2.02040640 |
| 20 | MP0001661_extended_life_span | 1.91005957 |
| 21 | MP0008058_abnormal_DNA_repair | 1.89629484 |
| 22 | MP0002822_catalepsy | 1.83064712 |
| 23 | MP0005084_abnormal_gallbladder_morpholo | 1.72075524 |
| 24 | MP0010155_abnormal_intestine_physiology | 1.71878978 |
| 25 | MP0003011_delayed_dark_adaptation | 1.71582017 |
| 26 | MP0005379_endocrine/exocrine_gland_phen | 1.70810583 |
| 27 | MP0000647_abnormal_sebaceous_gland | 1.69903888 |
| 28 | MP0001919_abnormal_reproductive_system | 1.68917626 |
| 29 | MP0003880_abnormal_central_pattern | 1.67020228 |
| 30 | MP0001873_stomach_inflammation | 1.61708236 |
| 31 | MP0003111_abnormal_nucleus_morphology | 1.60165789 |
| 32 | MP0008873_increased_physiological_sensi | 1.58098868 |
| 33 | MP0005645_abnormal_hypothalamus_physiol | 1.57876910 |
| 34 | MP0002095_abnormal_skin_pigmentation | 1.57614798 |
| 35 | MP0002938_white_spotting | 1.56592525 |
| 36 | MP0008877_abnormal_DNA_methylation | 1.54237481 |
| 37 | MP0008872_abnormal_physiological_respon | 1.53453767 |
| 38 | MP0001986_abnormal_taste_sensitivity | 1.51025669 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.45442556 |
| 40 | MP0002148_abnormal_hypersensitivity_rea | 1.43956940 |
| 41 | MP0000490_abnormal_crypts_of | 1.42374068 |
| 42 | MP0004957_abnormal_blastocyst_morpholog | 1.39139529 |
| 43 | MP0003567_abnormal_fetal_cardiomyocyte | 1.37176696 |
| 44 | MP0001764_abnormal_homeostasis | 1.36784409 |
| 45 | MP0001984_abnormal_olfaction | 1.34946392 |
| 46 | MP0000372_irregular_coat_pigmentation | 1.34811985 |
| 47 | MP0005171_absent_coat_pigmentation | 1.34083706 |
| 48 | MP0006036_abnormal_mitochondrial_physio | 1.27636036 |
| 49 | MP0008007_abnormal_cellular_replicative | 1.24017577 |
| 50 | MP0001835_abnormal_antigen_presentation | 1.21874841 |
| 51 | MP0004782_abnormal_surfactant_physiolog | 1.15718455 |
| 52 | MP0009333_abnormal_splenocyte_physiolog | 1.15301920 |
| 53 | MP0002396_abnormal_hematopoietic_system | 1.14254686 |
| 54 | MP0005389_reproductive_system_phenotype | 1.13587693 |
| 55 | MP0003077_abnormal_cell_cycle | 1.12769460 |
| 56 | MP0002876_abnormal_thyroid_physiology | 1.11093707 |
| 57 | MP0002282_abnormal_trachea_morphology | 1.10173595 |
| 58 | MP0001800_abnormal_humoral_immune | 1.09943983 |
| 59 | MP0001346_abnormal_lacrimal_gland | 1.07878082 |
| 60 | MP0008057_abnormal_DNA_replication | 1.07215733 |
| 61 | MP0003195_calcinosis | 1.03163554 |
| 62 | MP0003786_premature_aging | 1.02568564 |
| 63 | MP0008932_abnormal_embryonic_tissue | 0.99809000 |
| 64 | MP0005365_abnormal_bile_salt | 0.98961294 |
| 65 | MP0001293_anophthalmia | 0.98748423 |
| 66 | MP0004019_abnormal_vitamin_homeostasis | 0.97048214 |
| 67 | MP0005310_abnormal_salivary_gland | 0.96295244 |
| 68 | MP0001243_abnormal_dermal_layer | 0.95237306 |
| 69 | MP0001177_atelectasis | 0.92988886 |
| 70 | MP0002138_abnormal_hepatobiliary_system | 0.92055902 |
| 71 | MP0006276_abnormal_autonomic_nervous | 0.91467763 |
| 72 | MP0005410_abnormal_fertilization | 0.89134267 |
| 73 | MP0005195_abnormal_posterior_eye | 0.89012384 |
| 74 | MP0003936_abnormal_reproductive_system | 0.85516520 |
| 75 | MP0005391_vision/eye_phenotype | 0.82976891 |
| 76 | MP0003436_decreased_susceptibility_to | 0.82444338 |
| 77 | MP0003718_maternal_effect | 0.79445075 |
| 78 | MP0001929_abnormal_gametogenesis | 0.79440843 |
| 79 | MP0005386_behavior/neurological_phenoty | 0.79057636 |
| 80 | MP0004924_abnormal_behavior | 0.79057636 |
| 81 | MP0000653_abnormal_sex_gland | 0.78136198 |
| 82 | MP0009697_abnormal_copulation | 0.77470593 |
| 83 | MP0002723_abnormal_immune_serum | 0.77292260 |
| 84 | MP0000383_abnormal_hair_follicle | 0.76593020 |
| 85 | MP0005647_abnormal_sex_gland | 0.75634730 |
| 86 | MP0005319_abnormal_enzyme/_coenzyme | 0.72893804 |
| 87 | MP0000778_abnormal_nervous_system | 0.72820113 |
| 88 | MP0004147_increased_porphyrin_level | 0.72216081 |
| 89 | MP0003698_abnormal_male_reproductive | 0.71971024 |
| 90 | MP0002210_abnormal_sex_determination | 0.71882907 |
| 91 | MP0001145_abnormal_male_reproductive | 0.71167202 |
| 92 | MP0000358_abnormal_cell_content/ | 0.69442124 |
| 93 | MP0003943_abnormal_hepatobiliary_system | 0.69015766 |
| 94 | MP0004484_altered_response_of | 0.68476119 |
| 95 | MP0002452_abnormal_antigen_presenting | 0.66546645 |
| 96 | MP0000703_abnormal_thymus_morphology | 0.64903982 |
| 97 | MP0002405_respiratory_system_inflammati | 0.64875824 |
| 98 | MP0002229_neurodegeneration | 0.63174848 |
| 99 | MP0002272_abnormal_nervous_system | 0.62954709 |
| 100 | MP0005085_abnormal_gallbladder_physiolo | 0.62887278 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.85482256 |
| 2 | Recurrent cutaneous fungal infections (HP:0011370) | 4.85482256 |
| 3 | Increased hepatocellular lipid droplets (HP:0006565) | 3.89186728 |
| 4 | Lipid accumulation in hepatocytes (HP:0006561) | 3.80877345 |
| 5 | Submucous cleft hard palate (HP:0000176) | 3.56447497 |
| 6 | Central scotoma (HP:0000603) | 3.37786947 |
| 7 | Pendular nystagmus (HP:0012043) | 3.32797211 |
| 8 | Attenuation of retinal blood vessels (HP:0007843) | 3.01698927 |
| 9 | Entropion (HP:0000621) | 3.00955851 |
| 10 | Posterior subcapsular cataract (HP:0007787) | 2.91798401 |
| 11 | Mitochondrial inheritance (HP:0001427) | 2.83650930 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.82274236 |
| 13 | Constricted visual fields (HP:0001133) | 2.81744270 |
| 14 | Carpal bone hypoplasia (HP:0001498) | 2.75516992 |
| 15 | Increased CSF lactate (HP:0002490) | 2.73602582 |
| 16 | Methylmalonic acidemia (HP:0002912) | 2.72734542 |
| 17 | Mesangial abnormality (HP:0001966) | 2.66739224 |
| 18 | Renal Fanconi syndrome (HP:0001994) | 2.66253883 |
| 19 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.63148491 |
| 20 | Decreased central vision (HP:0007663) | 2.62163792 |
| 21 | Acute necrotizing encephalopathy (HP:0006965) | 2.61846116 |
| 22 | Congenital, generalized hypertrichosis (HP:0004540) | 2.55153068 |
| 23 | Abnormality of chromosome stability (HP:0003220) | 2.51827629 |
| 24 | IgG deficiency (HP:0004315) | 2.51516092 |
| 25 | Congenital stationary night blindness (HP:0007642) | 2.49555441 |
| 26 | Abolished electroretinogram (ERG) (HP:0000550) | 2.46064544 |
| 27 | Hepatocellular necrosis (HP:0001404) | 2.43947995 |
| 28 | Cerebellar dysplasia (HP:0007033) | 2.43568319 |
| 29 | Scotoma (HP:0000575) | 2.43082733 |
| 30 | Severe combined immunodeficiency (HP:0004430) | 2.42625828 |
| 31 | Abnormality of macular pigmentation (HP:0008002) | 2.41740786 |
| 32 | Stomatitis (HP:0010280) | 2.41610583 |
| 33 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.37502032 |
| 34 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.37502032 |
| 35 | Increased intramyocellular lipid droplets (HP:0012240) | 2.36309579 |
| 36 | Glucose intolerance (HP:0000833) | 2.34481876 |
| 37 | Cheilitis (HP:0100825) | 2.31877838 |
| 38 | Increased serum pyruvate (HP:0003542) | 2.31712513 |
| 39 | Abnormality of T cell physiology (HP:0011840) | 2.29884366 |
| 40 | Meckel diverticulum (HP:0002245) | 2.29794965 |
| 41 | Medial flaring of the eyebrow (HP:0010747) | 2.25047871 |
| 42 | Thyroiditis (HP:0100646) | 2.20799670 |
| 43 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.19946552 |
| 44 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.17326890 |
| 45 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.16029105 |
| 46 | Methylmalonic aciduria (HP:0012120) | 2.14205767 |
| 47 | Hepatic necrosis (HP:0002605) | 2.13202946 |
| 48 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.11997073 |
| 49 | Abnormality of the ileum (HP:0001549) | 2.09040091 |
| 50 | Optic disc pallor (HP:0000543) | 2.07738611 |
| 51 | Increased serum lactate (HP:0002151) | 2.07661290 |
| 52 | Colon cancer (HP:0003003) | 2.07493748 |
| 53 | Absent speech (HP:0001344) | 2.06708969 |
| 54 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.06535654 |
| 55 | Hypothermia (HP:0002045) | 2.05659392 |
| 56 | Exertional dyspnea (HP:0002875) | 2.04936249 |
| 57 | Increased muscle lipid content (HP:0009058) | 2.04421497 |
| 58 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.03379530 |
| 59 | Pancreatic cysts (HP:0001737) | 2.02778552 |
| 60 | Abnormality of glycolysis (HP:0004366) | 2.02510149 |
| 61 | Acute encephalopathy (HP:0006846) | 2.02486361 |
| 62 | Nephrogenic diabetes insipidus (HP:0009806) | 2.02453400 |
| 63 | Renal cortical cysts (HP:0000803) | 2.01963292 |
| 64 | Increased IgM level (HP:0003496) | 2.01795117 |
| 65 | Progressive macrocephaly (HP:0004481) | 2.01654415 |
| 66 | Short 4th metacarpal (HP:0010044) | 2.00978196 |
| 67 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.00978196 |
| 68 | Adactyly (HP:0009776) | 2.00010881 |
| 69 | Stillbirth (HP:0003826) | 1.97650099 |
| 70 | Combined immunodeficiency (HP:0005387) | 1.97618585 |
| 71 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.97117142 |
| 72 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.97098656 |
| 73 | Abnormal lung lobation (HP:0002101) | 1.96909081 |
| 74 | Intestinal atresia (HP:0011100) | 1.96600561 |
| 75 | Cerebral edema (HP:0002181) | 1.96037819 |
| 76 | Chronic diarrhea (HP:0002028) | 1.92463013 |
| 77 | Brittle hair (HP:0002299) | 1.92348487 |
| 78 | Postaxial foot polydactyly (HP:0001830) | 1.92011101 |
| 79 | Adrenal hypoplasia (HP:0000835) | 1.91134359 |
| 80 | Congenital primary aphakia (HP:0007707) | 1.90810884 |
| 81 | Chorioretinal atrophy (HP:0000533) | 1.85895593 |
| 82 | Severe muscular hypotonia (HP:0006829) | 1.82670302 |
| 83 | Panhypogammaglobulinemia (HP:0003139) | 1.81792109 |
| 84 | Type II lissencephaly (HP:0007260) | 1.81458500 |
| 85 | Gait imbalance (HP:0002141) | 1.80254278 |
| 86 | Keratoconjunctivitis (HP:0001096) | 1.79885423 |
| 87 | Median cleft lip (HP:0000161) | 1.79141105 |
| 88 | True hermaphroditism (HP:0010459) | 1.77514113 |
| 89 | Lactic acidosis (HP:0003128) | 1.77035141 |
| 90 | Hypoproteinemia (HP:0003075) | 1.76990954 |
| 91 | Clubbing of toes (HP:0100760) | 1.76617016 |
| 92 | Dyschromatopsia (HP:0007641) | 1.75860539 |
| 93 | Sloping forehead (HP:0000340) | 1.72914693 |
| 94 | Neuroendocrine neoplasm (HP:0100634) | 1.72593111 |
| 95 | Abnormality of renal resorption (HP:0011038) | 1.72477342 |
| 96 | Hypoplastic pelvis (HP:0008839) | 1.71396777 |
| 97 | Rhabdomyosarcoma (HP:0002859) | 1.71029371 |
| 98 | Abnormal protein glycosylation (HP:0012346) | 1.68732267 |
| 99 | Abnormal glycosylation (HP:0012345) | 1.68732267 |
| 100 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.68732267 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NEK1 | 7.04993663 |
| 2 | TSSK6 | 3.56221413 |
| 3 | ZAK | 3.26176410 |
| 4 | NUAK1 | 3.07418174 |
| 5 | VRK2 | 2.64308569 |
| 6 | EIF2AK3 | 2.63297989 |
| 7 | TLK1 | 2.55136883 |
| 8 | TXK | 2.46575299 |
| 9 | VRK1 | 2.43463987 |
| 10 | SRPK1 | 2.35606962 |
| 11 | PBK | 2.20103216 |
| 12 | TAF1 | 2.13893752 |
| 13 | BCKDK | 2.08400056 |
| 14 | PLK3 | 2.03351437 |
| 15 | BUB1 | 2.02033512 |
| 16 | ADRBK2 | 1.81559723 |
| 17 | TRIM28 | 1.81425121 |
| 18 | CSNK1G2 | 1.79102150 |
| 19 | MST4 | 1.72024731 |
| 20 | MAPK13 | 1.69366192 |
| 21 | BCR | 1.66004121 |
| 22 | GRK1 | 1.46507201 |
| 23 | CSNK1G3 | 1.45255120 |
| 24 | CCNB1 | 1.45064727 |
| 25 | TTK | 1.41519354 |
| 26 | MAP4K2 | 1.37961033 |
| 27 | WNK4 | 1.34802116 |
| 28 | MAP2K7 | 1.30483277 |
| 29 | CSNK1G1 | 1.29645845 |
| 30 | MAP3K4 | 1.28285395 |
| 31 | FLT3 | 1.22167529 |
| 32 | EIF2AK1 | 1.20888193 |
| 33 | CSNK1A1L | 1.16040765 |
| 34 | CLK1 | 0.99994533 |
| 35 | EPHA4 | 0.96485830 |
| 36 | ACVR1B | 0.95404866 |
| 37 | EIF2AK2 | 0.93016917 |
| 38 | STK38L | 0.90716850 |
| 39 | WEE1 | 0.87360425 |
| 40 | PLK4 | 0.86126366 |
| 41 | STK39 | 0.79809301 |
| 42 | STK24 | 0.78853858 |
| 43 | DYRK2 | 0.76967153 |
| 44 | STK16 | 0.76548808 |
| 45 | ATR | 0.76543055 |
| 46 | CDC7 | 0.76297964 |
| 47 | DAPK1 | 0.74423477 |
| 48 | PRKD3 | 0.74024773 |
| 49 | FRK | 0.73015611 |
| 50 | PLK1 | 0.71994536 |
| 51 | AURKA | 0.70702102 |
| 52 | CAMKK2 | 0.69417068 |
| 53 | WNK3 | 0.67947319 |
| 54 | PASK | 0.65534261 |
| 55 | OXSR1 | 0.65193541 |
| 56 | AURKB | 0.63885486 |
| 57 | DAPK2 | 0.62501017 |
| 58 | TIE1 | 0.59170126 |
| 59 | PNCK | 0.58297916 |
| 60 | MKNK1 | 0.58021856 |
| 61 | PLK2 | 0.56986378 |
| 62 | BRSK2 | 0.54771560 |
| 63 | UHMK1 | 0.49837014 |
| 64 | MAPKAPK5 | 0.48628586 |
| 65 | TAOK3 | 0.45918785 |
| 66 | MKNK2 | 0.45799702 |
| 67 | CDK7 | 0.44875271 |
| 68 | PRKCQ | 0.42521246 |
| 69 | DAPK3 | 0.39700906 |
| 70 | ATM | 0.39394506 |
| 71 | CSNK2A1 | 0.38714075 |
| 72 | TEC | 0.36039415 |
| 73 | GRK5 | 0.35667408 |
| 74 | ILK | 0.35118103 |
| 75 | INSRR | 0.34673806 |
| 76 | MAP3K5 | 0.34556047 |
| 77 | MINK1 | 0.34421154 |
| 78 | CDK3 | 0.34251233 |
| 79 | NEK2 | 0.34191036 |
| 80 | NME1 | 0.34066961 |
| 81 | PHKG2 | 0.33395929 |
| 82 | PHKG1 | 0.33395929 |
| 83 | CHEK1 | 0.32161321 |
| 84 | CHEK2 | 0.31895901 |
| 85 | CSF1R | 0.30117196 |
| 86 | CDK18 | 0.30012528 |
| 87 | KIT | 0.29950706 |
| 88 | RPS6KB1 | 0.29451974 |
| 89 | OBSCN | 0.28564781 |
| 90 | CSNK2A2 | 0.28244176 |
| 91 | MAP3K14 | 0.28213138 |
| 92 | CAMK2A | 0.27977069 |
| 93 | PRKCE | 0.27714334 |
| 94 | MAP2K6 | 0.27694832 |
| 95 | CSNK1D | 0.26341869 |
| 96 | STK3 | 0.26325698 |
| 97 | RPS6KB2 | 0.25939732 |
| 98 | MAP3K12 | 0.25814918 |
| 99 | CSNK1A1 | 0.25767178 |
| 100 | CDK15 | 0.24848789 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.42851946 |
| 2 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.90474181 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.34547119 |
| 4 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.87086848 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.74757764 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.72546710 |
| 7 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.43496434 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.40506327 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.29898906 |
| 10 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.24185947 |
| 11 | Phototransduction_Homo sapiens_hsa04744 | 2.15426320 |
| 12 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.09547120 |
| 13 | Parkinsons disease_Homo sapiens_hsa05012 | 2.08145041 |
| 14 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.06571670 |
| 15 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.02981496 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.96209742 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.91835191 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.91287381 |
| 19 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.89780998 |
| 20 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.78531405 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.74781833 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.73214710 |
| 23 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.72037228 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.69494800 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.66407837 |
| 26 | Spliceosome_Homo sapiens_hsa03040 | 1.45621661 |
| 27 | RNA transport_Homo sapiens_hsa03013 | 1.44707776 |
| 28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.41449769 |
| 29 | RNA polymerase_Homo sapiens_hsa03020 | 1.32166921 |
| 30 | Huntingtons disease_Homo sapiens_hsa05016 | 1.31349428 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.25102895 |
| 32 | Base excision repair_Homo sapiens_hsa03410 | 1.19218041 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.19155385 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.16773145 |
| 35 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16558571 |
| 36 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.15714169 |
| 37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.13906657 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.12945563 |
| 39 | Ribosome_Homo sapiens_hsa03010 | 1.12638915 |
| 40 | Alcoholism_Homo sapiens_hsa05034 | 1.06453471 |
| 41 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.02805979 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.02693688 |
| 43 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.98675351 |
| 44 | Allograft rejection_Homo sapiens_hsa05330 | 0.96325503 |
| 45 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.95168445 |
| 46 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.91778504 |
| 47 | Cell cycle_Homo sapiens_hsa04110 | 0.86568153 |
| 48 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.84370776 |
| 49 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.80986516 |
| 50 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.79693743 |
| 51 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.79601375 |
| 52 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.78973730 |
| 53 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.78234924 |
| 54 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.76904782 |
| 55 | Peroxisome_Homo sapiens_hsa04146 | 0.75335104 |
| 56 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.70435463 |
| 57 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.69888155 |
| 58 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.69343595 |
| 59 | Metabolic pathways_Homo sapiens_hsa01100 | 0.66458845 |
| 60 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.66253718 |
| 61 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.65487034 |
| 62 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.64376591 |
| 63 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.63888978 |
| 64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.63297856 |
| 65 | Measles_Homo sapiens_hsa05162 | 0.62295405 |
| 66 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.62247364 |
| 67 | Carbon metabolism_Homo sapiens_hsa01200 | 0.60651501 |
| 68 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.56655210 |
| 69 | Olfactory transduction_Homo sapiens_hsa04740 | 0.56485845 |
| 70 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.55607158 |
| 71 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.53215684 |
| 72 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.51858463 |
| 73 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.51511022 |
| 74 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.49623590 |
| 75 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.49279748 |
| 76 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.48674224 |
| 77 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.48662439 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.45064056 |
| 79 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.44856190 |
| 80 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.43849705 |
| 81 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.42699827 |
| 82 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.41539218 |
| 83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.41071450 |
| 84 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.40931599 |
| 85 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.38665283 |
| 86 | Asthma_Homo sapiens_hsa05310 | 0.37093767 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36396220 |
| 88 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.35861267 |
| 89 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.34218922 |
| 90 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.33782616 |
| 91 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.33056264 |
| 92 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.29396940 |
| 93 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.28380733 |
| 94 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.27510449 |
| 95 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.25918031 |
| 96 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.24497358 |
| 97 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.24318617 |
| 98 | Sulfur relay system_Homo sapiens_hsa04122 | 0.22611168 |
| 99 | Morphine addiction_Homo sapiens_hsa05032 | 0.22095711 |
| 100 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.21457395 |

