VDAC1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.16696916
2spindle assembly involved in mitosis (GO:0090307)5.86926650
3prostate gland growth (GO:0060736)5.73818877
4regulation of cell proliferation involved in kidney development (GO:1901722)5.60907033
5sulfation (GO:0051923)5.47823480
6mitochondrial respiratory chain complex I assembly (GO:0032981)5.35954334
7NADH dehydrogenase complex assembly (GO:0010257)5.35954334
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.35954334
9DNA deamination (GO:0045006)5.35200546
10anterior/posterior axis specification, embryo (GO:0008595)5.31595408
11cell proliferation in forebrain (GO:0021846)4.91323081
12negative regulation of Rho protein signal transduction (GO:0035024)4.84276215
13regulation of tight junction assembly (GO:2000810)4.81892255
14positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.75169006
15response to lipoprotein particle (GO:0055094)4.68290682
16positive regulation of mitochondrial fission (GO:0090141)4.65012266
17centrosome duplication (GO:0051298)4.51999913
18microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.47361432
19regulation of inositol phosphate biosynthetic process (GO:0010919)4.44720825
20mitochondrion morphogenesis (GO:0070584)4.42997055
21synapsis (GO:0007129)4.40370412
22lung-associated mesenchyme development (GO:0060484)4.39172486
23protein complex biogenesis (GO:0070271)4.26717366
24cell differentiation involved in embryonic placenta development (GO:0060706)4.15038646
25positive regulation of oligodendrocyte differentiation (GO:0048714)4.13188717
26positive regulation of fatty acid oxidation (GO:0046321)4.11682253
27negative regulation of telomerase activity (GO:0051974)4.05080943
28regulation of energy homeostasis (GO:2000505)3.99927870
29mitochondrial respiratory chain complex assembly (GO:0033108)3.91119929
30preassembly of GPI anchor in ER membrane (GO:0016254)3.89951262
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.82152186
32purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.82152186
33negative regulation of kidney development (GO:0090185)3.78634059
34behavioral response to nicotine (GO:0035095)3.72160645
35inner cell mass cell proliferation (GO:0001833)3.69266837
36water-soluble vitamin biosynthetic process (GO:0042364)3.65071138
37regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.64974720
38negative regulation of mast cell activation (GO:0033004)3.64255322
39peroxisome fission (GO:0016559)3.61593117
40dentate gyrus development (GO:0021542)3.60813665
41peripheral nervous system axon ensheathment (GO:0032292)3.57688579
42myelination in peripheral nervous system (GO:0022011)3.57688579
43regulation of sequestering of triglyceride (GO:0010889)3.48645070
44negative regulation of acute inflammatory response (GO:0002674)3.48006022
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45703123
46flavonoid metabolic process (GO:0009812)3.41638383
47regulation of telomerase activity (GO:0051972)3.41272116
48serine family amino acid catabolic process (GO:0009071)3.40821851
49regulation of mitochondrial fission (GO:0090140)3.37827543
50magnesium ion transport (GO:0015693)3.37121905
51gland morphogenesis (GO:0022612)3.37013732
52white fat cell differentiation (GO:0050872)3.35199802
53positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.34137936
54somite development (GO:0061053)3.29657393
55presynaptic membrane assembly (GO:0097105)3.19182905
56regulation of mesoderm development (GO:2000380)3.16825672
57negative regulation of systemic arterial blood pressure (GO:0003085)3.11678219
58regulation of glomerulus development (GO:0090192)3.09057458
59ventricular septum development (GO:0003281)3.06980658
60regulation of collateral sprouting (GO:0048670)3.03655527
61response to caffeine (GO:0031000)3.02654835
62protein kinase C signaling (GO:0070528)3.00995988
63peristalsis (GO:0030432)2.98460374
64cellular response to ATP (GO:0071318)2.97831381
65spinal cord development (GO:0021510)2.96223951
66embryonic camera-type eye development (GO:0031076)2.95991366
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.91210226
68regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.91050447
69cellular response to lithium ion (GO:0071285)2.89401899
70regulation of DNA endoreduplication (GO:0032875)2.88800474
71negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87796762
72otic vesicle formation (GO:0030916)2.83482138
73negative regulation of astrocyte differentiation (GO:0048712)2.82398680
74chromosome organization involved in meiosis (GO:0070192)2.81997363
75negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.81078268
76DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79233242
77estrogen metabolic process (GO:0008210)2.74828633
78interferon-gamma secretion (GO:0072643)2.74780484
79replicative senescence (GO:0090399)2.73607508
80cellular response to exogenous dsRNA (GO:0071360)2.73501998
81glycine metabolic process (GO:0006544)2.73134393
82calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71905707
83mitochondrial fusion (GO:0008053)2.71899355
84presynaptic membrane organization (GO:0097090)2.67211299
85negative regulation of DNA biosynthetic process (GO:2000279)2.66350852
86signal transduction involved in regulation of gene expression (GO:0023019)2.65235536
87mannosylation (GO:0097502)2.64746076
88protein polyglutamylation (GO:0018095)2.64531463
89epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.62104594
90regulation of action potential (GO:0098900)2.60730026
91organ growth (GO:0035265)2.60701240
92pituitary gland development (GO:0021983)2.60118391
93T cell lineage commitment (GO:0002360)2.58695569
94double-strand break repair via homologous recombination (GO:0000724)2.58547206
95regulation of germinal center formation (GO:0002634)2.55998297
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.55837411
97recombinational repair (GO:0000725)2.55547599
98TOR signaling (GO:0031929)2.54430475
99mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.52551227
100branching involved in labyrinthine layer morphogenesis (GO:0060670)10.5249986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.24264099
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32449894
3GBX2_23144817_ChIP-Seq_PC3_Human3.18509161
4EZH2_22144423_ChIP-Seq_EOC_Human3.04539421
5FUS_26573619_Chip-Seq_HEK293_Human2.84226981
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.77693582
7ZNF274_21170338_ChIP-Seq_K562_Hela2.74047397
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44814488
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28694823
10IGF1R_20145208_ChIP-Seq_DFB_Human2.24665771
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22501440
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.04326277
13EWS_26573619_Chip-Seq_HEK293_Human2.02407411
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00729165
15MYC_18940864_ChIP-ChIP_HL60_Human1.93176743
16IRF1_19129219_ChIP-ChIP_H3396_Human1.92271616
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92230792
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.90047558
19VDR_22108803_ChIP-Seq_LS180_Human1.87908193
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85938577
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84648805
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83906268
23ER_23166858_ChIP-Seq_MCF-7_Human1.83048434
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82546321
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.75392970
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75007669
27P300_19829295_ChIP-Seq_ESCs_Human1.72976556
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.72340806
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69106418
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67495259
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67105757
32LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65660435
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.63765102
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61936606
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57741514
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53459609
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50839141
38RNF2_27304074_Chip-Seq_NSC_Mouse1.48787206
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.46078404
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.45725495
41TAF15_26573619_Chip-Seq_HEK293_Human1.43247205
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.36613735
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.35886059
44BCAT_22108803_ChIP-Seq_LS180_Human1.34778912
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.33645384
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31704098
47STAT3_23295773_ChIP-Seq_U87_Human1.31661568
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29623974
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29526362
50TCF4_23295773_ChIP-Seq_U87_Human1.29326439
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29203069
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28252446
53SMAD4_21799915_ChIP-Seq_A2780_Human1.28029899
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.26732426
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24996270
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24432244
57AHR_22903824_ChIP-Seq_MCF-7_Human1.23654478
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.22908173
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22050777
60NCOR_22424771_ChIP-Seq_293T_Human1.20103903
61AR_25329375_ChIP-Seq_VCAP_Human1.17761027
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17337766
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17337766
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13012634
65REST_21632747_ChIP-Seq_MESCs_Mouse1.09963240
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09782374
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09346573
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08020366
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06995622
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.06794755
71CBP_20019798_ChIP-Seq_JUKART_Human1.06532238
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06532238
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05297292
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.02316394
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.00781969
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00436212
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00318708
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99672062
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99672062
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.99524664
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99524664
82NANOG_18555785_Chip-Seq_ESCs_Mouse0.98560540
83FLI1_21867929_ChIP-Seq_TH2_Mouse0.98115242
84SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98009920
85RXR_22108803_ChIP-Seq_LS180_Human0.97432244
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96774594
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96650643
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95360530
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94394352
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94140773
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.93122922
92NANOG_19829295_ChIP-Seq_ESCs_Human0.93092781
93SOX2_19829295_ChIP-Seq_ESCs_Human0.93092781
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.92918522
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92419751
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91661457
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.91312132
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91260087
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91071443
100JUN_21703547_ChIP-Seq_K562_Human0.90610526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.46383147
2MP0005670_abnormal_white_adipose3.98681532
3MP0000516_abnormal_urinary_system3.53976577
4MP0005367_renal/urinary_system_phenotyp3.53976577
5MP0001485_abnormal_pinna_reflex3.35052652
6MP0003315_abnormal_perineum_morphology3.15419628
7MP0006292_abnormal_olfactory_placode3.10778119
8MP0000013_abnormal_adipose_tissue2.98625278
9MP0005646_abnormal_pituitary_gland2.82658867
10MP0000049_abnormal_middle_ear2.77910699
11MP0002160_abnormal_reproductive_system2.74229414
12MP0003693_abnormal_embryo_hatching2.33153465
13MP0002138_abnormal_hepatobiliary_system2.16559415
14MP0009053_abnormal_anal_canal2.08196091
15MP0008877_abnormal_DNA_methylation2.06408990
16MP0002876_abnormal_thyroid_physiology2.00420587
17MP0005389_reproductive_system_phenotype1.92733271
18MP0003937_abnormal_limbs/digits/tail_de1.86906696
19MP0000631_abnormal_neuroendocrine_gland1.81618208
20MP0003724_increased_susceptibility_to1.75814201
21MP0008872_abnormal_physiological_respon1.75615960
22MP0003119_abnormal_digestive_system1.72686603
23MP0009765_abnormal_xenobiotic_induced1.69268047
24MP0002102_abnormal_ear_morphology1.66891055
25MP0001849_ear_inflammation1.65303050
26MP0004885_abnormal_endolymph1.60773660
27MP0003283_abnormal_digestive_organ1.51313922
28MP0000569_abnormal_digit_pigmentation1.49796009
29MP0002837_dystrophic_cardiac_calcinosis1.49771858
30MP0004130_abnormal_muscle_cell1.46489943
31MP0005174_abnormal_tail_pigmentation1.44853363
32MP0006072_abnormal_retinal_apoptosis1.43336216
33MP0009250_abnormal_appendicular_skeleto1.42927125
34MP0004133_heterotaxia1.36807086
35MP0001661_extended_life_span1.36728793
36MP0003936_abnormal_reproductive_system1.32035224
37MP0009384_cardiac_valve_regurgitation1.31370776
38MP0003656_abnormal_erythrocyte_physiolo1.31236675
39MP0002282_abnormal_trachea_morphology1.30554869
40MP0008789_abnormal_olfactory_epithelium1.29106242
41MP0003718_maternal_effect1.26291313
42MP0002132_abnormal_respiratory_system1.25870339
43MP0005551_abnormal_eye_electrophysiolog1.25443839
44MP0002751_abnormal_autonomic_nervous1.20682129
45MP0003567_abnormal_fetal_cardiomyocyte1.15543139
46MP0005253_abnormal_eye_physiology1.15136530
47MP0004142_abnormal_muscle_tone1.14602081
48MP0003195_calcinosis1.10600059
49MP0003890_abnormal_embryonic-extraembry1.10433448
50MP0004185_abnormal_adipocyte_glucose1.09529863
51MP0005195_abnormal_posterior_eye1.09224815
52MP0005084_abnormal_gallbladder_morpholo1.08849692
53MP0009046_muscle_twitch1.08770720
54MP0002272_abnormal_nervous_system1.03464796
55MP0010094_abnormal_chromosome_stability1.00065217
56MP0002928_abnormal_bile_duct0.97980716
57MP0000003_abnormal_adipose_tissue0.96116360
58MP0003938_abnormal_ear_development0.94945517
59MP0001440_abnormal_grooming_behavior0.93601241
60MP0001963_abnormal_hearing_physiology0.92667620
61MP0000015_abnormal_ear_pigmentation0.91509982
62MP0004134_abnormal_chest_morphology0.91062096
63MP0002095_abnormal_skin_pigmentation0.90268601
64MP0000383_abnormal_hair_follicle0.89550982
65MP0009745_abnormal_behavioral_response0.87036852
66MP0000778_abnormal_nervous_system0.86939805
67MP0003172_abnormal_lysosome_physiology0.84702892
68MP0001188_hyperpigmentation0.82753700
69MP0002938_white_spotting0.82449737
70MP0001270_distended_abdomen0.81126096
71MP0003011_delayed_dark_adaptation0.78691155
72MP0005499_abnormal_olfactory_system0.77940916
73MP0005394_taste/olfaction_phenotype0.77940916
74MP0003635_abnormal_synaptic_transmissio0.77764633
75MP0001119_abnormal_female_reproductive0.76740158
76MP0002163_abnormal_gland_morphology0.76483629
77MP0001919_abnormal_reproductive_system0.76076685
78MP0001968_abnormal_touch/_nociception0.74406251
79MP0000613_abnormal_salivary_gland0.71304517
80MP0001764_abnormal_homeostasis0.69795151
81MP0002064_seizures0.68838682
82MP0002139_abnormal_hepatobiliary_system0.68145651
83MP0008770_decreased_survivor_rate0.68011516
84MP0001145_abnormal_male_reproductive0.67215679
85MP0008058_abnormal_DNA_repair0.66673550
86MP0002116_abnormal_craniofacial_bone0.66390830
87MP0002210_abnormal_sex_determination0.65016897
88MP0002572_abnormal_emotion/affect_behav0.63787040
89MP0000678_abnormal_parathyroid_gland0.63682316
90MP0000653_abnormal_sex_gland0.63465312
91MP0003942_abnormal_urinary_system0.62952325
92MP0000537_abnormal_urethra_morphology0.62799647
93MP0003787_abnormal_imprinting0.61692734
94MP0001502_abnormal_circadian_rhythm0.61169541
95MP0005645_abnormal_hypothalamus_physiol0.58420742
96MP0002638_abnormal_pupillary_reflex0.58303406
97MP0002557_abnormal_social/conspecific_i0.57334047
98MP0000026_abnormal_inner_ear0.56918498
99MP0001986_abnormal_taste_sensitivity0.56442201
100MP0001944_abnormal_pancreas_morphology0.56414938

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)6.30989698
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)6.30989698
3Stenosis of the external auditory canal (HP:0000402)5.52980113
4Abnormality of the 1st metacarpal (HP:0010009)5.52973957
5Ectopic kidney (HP:0000086)4.85731638
6Carpal bone hypoplasia (HP:0001498)4.39051745
7Absent thumb (HP:0009777)4.24821330
8Short phalanx of the thumb (HP:0009660)4.03670230
9Abnormality of DNA repair (HP:0003254)3.98119182
10Abnormality of the renal collecting system (HP:0004742)3.92441100
11Rectovaginal fistula (HP:0000143)3.82657491
12Rectal fistula (HP:0100590)3.82657491
13Short hallux (HP:0010109)3.82150841
14Osteomalacia (HP:0002749)3.81460439
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73236959
16Duplicated collecting system (HP:0000081)3.62812417
17Pendular nystagmus (HP:0012043)3.60461907
18Aplasia/Hypoplasia of the hallux (HP:0008362)3.55774461
19Fused cervical vertebrae (HP:0002949)3.49720790
20Chromsome breakage (HP:0040012)3.39903899
21Intestinal fistula (HP:0100819)3.28182592
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.18717622
23Vaginal fistula (HP:0004320)3.11900348
24Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.11477253
25Aplasia/Hypoplasia involving the musculature (HP:0001460)3.04153095
26Acanthocytosis (HP:0001927)2.98703910
27Synostosis of carpal bones (HP:0005048)2.97531406
28Abnormality of the parathyroid morphology (HP:0011766)2.92540082
29Horseshoe kidney (HP:0000085)2.88674742
30Abolished electroretinogram (ERG) (HP:0000550)2.88282156
31Absent radius (HP:0003974)2.78092630
32Pancreatic cysts (HP:0001737)2.74231485
33Absent forearm bone (HP:0003953)2.68527039
34Aplasia involving forearm bones (HP:0009822)2.68527039
35Congenital sensorineural hearing impairment (HP:0008527)2.63306030
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.61040470
37Short thumb (HP:0009778)2.59213061
38Abnormality of the proximal phalanges of the hand (HP:0009834)2.59129409
39Genetic anticipation (HP:0003743)2.56314731
40Pancreatic fibrosis (HP:0100732)2.53576217
41Chorioretinal atrophy (HP:0000533)2.49953842
42True hermaphroditism (HP:0010459)2.49680713
43Reticulocytopenia (HP:0001896)2.49638758
44Congenital stationary night blindness (HP:0007642)2.35322326
45Paralysis (HP:0003470)2.35263614
46Abnormality of the nasal septum (HP:0000419)2.34851418
47Short humerus (HP:0005792)2.33597652
48Meckel diverticulum (HP:0002245)2.31721507
49Decreased subcutaneous fat (HP:0001002)2.27110691
50Abnormality of the ileum (HP:0001549)2.26411456
51Aplasia/hypoplasia of the humerus (HP:0006507)2.24373741
52Triphalangeal thumb (HP:0001199)2.23726265
53Abnormality of the carotid arteries (HP:0005344)2.23133658
54Optic nerve coloboma (HP:0000588)2.22647725
55Tachypnea (HP:0002789)2.20039761
56Keratoconus (HP:0000563)2.17917757
57Increased corneal curvature (HP:0100692)2.17917757
58Abnormality of chromosome stability (HP:0003220)2.17390058
59Bony spicule pigmentary retinopathy (HP:0007737)2.15823058
60Progressive cerebellar ataxia (HP:0002073)2.15003411
61Hypoplasia of the ulna (HP:0003022)2.13271348
62Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.12194693
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09026636
64Abnormality of the middle phalanges of the toes (HP:0010183)2.07766380
65Oligomenorrhea (HP:0000876)2.04695463
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.03621712
67Absent/shortened dynein arms (HP:0200106)2.03621712
68Hypoplasia of the radius (HP:0002984)2.03342718
69Molar tooth sign on MRI (HP:0002419)2.02447388
70Abnormality of midbrain morphology (HP:0002418)2.02447388
71Acute necrotizing encephalopathy (HP:0006965)1.98663296
72Methylmalonic acidemia (HP:0002912)1.98438767
73Thyroiditis (HP:0100646)1.97665867
74Neoplasm of the oral cavity (HP:0100649)1.96830358
75Anal stenosis (HP:0002025)1.96088169
76Abnormality of the preputium (HP:0100587)1.96074157
77Abnormality of the phalanges of the 5th finger (HP:0004213)1.95450332
78Renal agenesis (HP:0000104)1.94259927
79Vitreoretinal degeneration (HP:0000655)1.93977887
80Carpal synostosis (HP:0009702)1.92405020
81Hypoplasia of the uterus (HP:0000013)1.86972850
82Abnormality of subcutaneous fat tissue (HP:0001001)1.86832725
83Clubbing of toes (HP:0100760)1.86656662
84Maternal diabetes (HP:0009800)1.84526026
85Nephronophthisis (HP:0000090)1.83139407
86Panhypogammaglobulinemia (HP:0003139)1.82381200
87Tented upper lip vermilion (HP:0010804)1.81694551
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81234035
89Abnormality of alanine metabolism (HP:0010916)1.81234035
90Hyperalaninemia (HP:0003348)1.81234035
91Vertebral fusion (HP:0002948)1.79563767
92Esotropia (HP:0000565)1.79330699
93Progressive macrocephaly (HP:0004481)1.79239734
94Symphalangism affecting the phalanges of the hand (HP:0009773)1.77844713
95Morphological abnormality of the middle ear (HP:0008609)1.76975950
96Preaxial foot polydactyly (HP:0001841)1.75100476
97Abnormality of pyrimidine metabolism (HP:0004353)1.74810671
98Abnormal mitochondria in muscle tissue (HP:0008316)1.74682424
99Aplasia/Hypoplasia of the ulna (HP:0006495)1.72286290
100Status epilepticus (HP:0002133)1.70245703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.04467166
2GRK14.59151157
3TLK13.83065695
4ADRBK23.18410219
5NUAK12.45861022
6BMPR1B2.31070414
7CDK92.28693951
8CDC72.25248721
9TAOK32.07579623
10PINK11.94813709
11ACVR1B1.92863907
12ZAK1.86157873
13INSRR1.67716116
14WNK31.66620742
15CDK191.42813867
16CSNK1G21.38090414
17STK161.34573061
18PLK21.34023644
19MAP2K71.30464994
20MAPK131.29626251
21MKNK21.28354228
22TAF11.27610075
23CSNK1G11.24697998
24CSNK1G31.23231070
25MAP2K11.20208233
26GRK71.19770483
27MAP4K21.19481050
28TRIM281.18427406
29CASK1.16301103
30CSNK1A1L1.15893717
31WNK41.14904247
32MAP3K41.14711776
33ATR1.10872946
34TNIK1.08408103
35SGK21.04861198
36PIK3CA1.03479377
37OXSR10.98242471
38PRKD20.97607030
39DYRK30.97574451
40TXK0.97560084
41SYK0.97162363
42CSNK1A10.94576016
43VRK10.90943547
44BRSK20.88732668
45SGK4940.87661615
46SGK2230.87661615
47ADRBK10.86730770
48AURKA0.84994417
49CSNK1D0.83089641
50STK390.81317951
51GRK50.78803938
52STK38L0.75301436
53DYRK20.73657564
54IKBKB0.72225280
55PRKCE0.70190558
56FGFR20.67211538
57NEK20.67101547
58FLT30.66591156
59VRK20.66369489
60PRKCG0.65452139
61BRD40.64434665
62PLK40.64024129
63PHKG20.62655120
64PHKG10.62655120
65NLK0.62541282
66PAK30.61966605
67MAP2K60.61219052
68PLK10.61067353
69ATM0.60450679
70MUSK0.58459099
71CDK30.57157536
72BLK0.56131252
73RPS6KA50.55134936
74LYN0.53586106
75TEC0.53418584
76PRKACA0.49666665
77MAP2K40.48021226
78MKNK10.47528940
79TIE10.46719009
80CSNK2A10.45580166
81NEK90.45342545
82SGK10.45321725
83CLK10.45285108
84OBSCN0.45281566
85SGK30.45265024
86PRKAA10.45221478
87TGFBR10.45017365
88CAMKK20.44171342
89PRKDC0.43636883
90PRKCQ0.42126833
91CHEK20.41740985
92MAPK110.41008234
93CCNB10.38104144
94CAMK10.36299819
95MAPK80.35669141
96MAPKAPK50.35576783
97NTRK30.35370610
98CHEK10.34975449
99PAK60.34900963
100GSK3B0.34785152

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.20967697
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.98479768
3Renin-angiotensin system_Homo sapiens_hsa046142.73004677
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.61845098
5Fanconi anemia pathway_Homo sapiens_hsa034602.57645414
6Sulfur metabolism_Homo sapiens_hsa009202.51744144
7Homologous recombination_Homo sapiens_hsa034402.50851365
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.36774222
9Nicotine addiction_Homo sapiens_hsa050332.35493720
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.33059826
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.14137163
12Phototransduction_Homo sapiens_hsa047442.10423175
13Selenocompound metabolism_Homo sapiens_hsa004501.95704237
14Collecting duct acid secretion_Homo sapiens_hsa049661.94495497
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92571313
16Nitrogen metabolism_Homo sapiens_hsa009101.70961315
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69655081
18Dorso-ventral axis formation_Homo sapiens_hsa043201.64705622
19RNA degradation_Homo sapiens_hsa030181.54887350
20Chemical carcinogenesis_Homo sapiens_hsa052041.54369882
21Linoleic acid metabolism_Homo sapiens_hsa005911.41747653
22RNA polymerase_Homo sapiens_hsa030201.41328372
23Taste transduction_Homo sapiens_hsa047421.33144182
24Butanoate metabolism_Homo sapiens_hsa006501.33078713
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32584486
26Basal cell carcinoma_Homo sapiens_hsa052171.31602565
27Oxidative phosphorylation_Homo sapiens_hsa001901.28604089
28Morphine addiction_Homo sapiens_hsa050321.27704504
29Retinol metabolism_Homo sapiens_hsa008301.23060949
30Basal transcription factors_Homo sapiens_hsa030221.23024897
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.19513348
32One carbon pool by folate_Homo sapiens_hsa006701.16565854
33Tryptophan metabolism_Homo sapiens_hsa003801.15255696
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12392807
35Systemic lupus erythematosus_Homo sapiens_hsa053221.12368554
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09618965
37Glycerolipid metabolism_Homo sapiens_hsa005611.07463475
38Ether lipid metabolism_Homo sapiens_hsa005651.05689443
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05416093
40Primary immunodeficiency_Homo sapiens_hsa053401.02815147
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01132339
42Insulin secretion_Homo sapiens_hsa049110.93643098
43Olfactory transduction_Homo sapiens_hsa047400.93020038
44Caffeine metabolism_Homo sapiens_hsa002320.89851202
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.88050478
46Alzheimers disease_Homo sapiens_hsa050100.87286412
47Vitamin digestion and absorption_Homo sapiens_hsa049770.86850639
48Melanoma_Homo sapiens_hsa052180.86608177
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86022410
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85214482
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82598041
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82358813
53Peroxisome_Homo sapiens_hsa041460.81382415
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80035318
55Parkinsons disease_Homo sapiens_hsa050120.79704867
56Huntingtons disease_Homo sapiens_hsa050160.78212028
57GABAergic synapse_Homo sapiens_hsa047270.74857195
58Protein export_Homo sapiens_hsa030600.73815564
59Fat digestion and absorption_Homo sapiens_hsa049750.70381960
60Hedgehog signaling pathway_Homo sapiens_hsa043400.69505748
61Asthma_Homo sapiens_hsa053100.69157672
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68788056
63Glutamatergic synapse_Homo sapiens_hsa047240.66858258
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66085592
65Circadian entrainment_Homo sapiens_hsa047130.65183568
66ABC transporters_Homo sapiens_hsa020100.64396518
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64080425
68Alcoholism_Homo sapiens_hsa050340.63988858
69Nucleotide excision repair_Homo sapiens_hsa034200.63801029
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61442873
71Regulation of autophagy_Homo sapiens_hsa041400.61075946
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60674193
73Sulfur relay system_Homo sapiens_hsa041220.60374742
74Calcium signaling pathway_Homo sapiens_hsa040200.58293019
75Propanoate metabolism_Homo sapiens_hsa006400.55693249
76Renin secretion_Homo sapiens_hsa049240.53772877
77TGF-beta signaling pathway_Homo sapiens_hsa043500.52199687
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50809196
79Serotonergic synapse_Homo sapiens_hsa047260.50423134
80Type II diabetes mellitus_Homo sapiens_hsa049300.49423746
81Ribosome_Homo sapiens_hsa030100.48882409
82Cholinergic synapse_Homo sapiens_hsa047250.48092056
83Hematopoietic cell lineage_Homo sapiens_hsa046400.47516070
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.47268444
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.47167666
86Axon guidance_Homo sapiens_hsa043600.44720479
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43620956
88Cardiac muscle contraction_Homo sapiens_hsa042600.43153876
89Metabolic pathways_Homo sapiens_hsa011000.39969524
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.38459643
91Hippo signaling pathway_Homo sapiens_hsa043900.37941745
92Ovarian steroidogenesis_Homo sapiens_hsa049130.37789005
93p53 signaling pathway_Homo sapiens_hsa041150.36468961
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34558377
95Purine metabolism_Homo sapiens_hsa002300.33896666
96Gastric acid secretion_Homo sapiens_hsa049710.33225780
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32176050
98Type I diabetes mellitus_Homo sapiens_hsa049400.31539569
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31127943
100Wnt signaling pathway_Homo sapiens_hsa043100.31108545

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