VDAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.11631080
2ATP synthesis coupled proton transport (GO:0015986)7.46971913
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.46971913
4tricarboxylic acid cycle (GO:0006099)6.50991232
5respiratory electron transport chain (GO:0022904)5.72677088
6oxidative phosphorylation (GO:0006119)5.62407701
7electron transport chain (GO:0022900)5.61023770
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.50796886
9ATP biosynthetic process (GO:0006754)4.68813714
10NADH metabolic process (GO:0006734)4.68089205
11cullin deneddylation (GO:0010388)4.58621134
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.44292529
13purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.35593878
14purine nucleoside triphosphate biosynthetic process (GO:0009145)4.28013018
15ribosome assembly (GO:0042255)4.24085556
16regulation of cofactor metabolic process (GO:0051193)4.14648572
17regulation of coenzyme metabolic process (GO:0051196)4.14648572
18protein deneddylation (GO:0000338)4.09239929
19protein neddylation (GO:0045116)4.08617334
20regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.04700555
21regulation of acyl-CoA biosynthetic process (GO:0050812)4.03406485
22ribonucleoside triphosphate biosynthetic process (GO:0009201)4.03221682
23ATP hydrolysis coupled proton transport (GO:0015991)3.98219107
24energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.98219107
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.94294823
26NADH dehydrogenase complex assembly (GO:0010257)3.94294823
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94294823
28hydrogen ion transmembrane transport (GO:1902600)3.94090330
29sarcomere organization (GO:0045214)3.88854173
30purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.82683396
31purine nucleoside monophosphate biosynthetic process (GO:0009127)3.82683396
32mitochondrial respiratory chain complex assembly (GO:0033108)3.78822055
33protein complex biogenesis (GO:0070271)3.74855310
34nucleoside triphosphate biosynthetic process (GO:0009142)3.64588879
35inner mitochondrial membrane organization (GO:0007007)3.58152147
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54150040
37tRNA aminoacylation for protein translation (GO:0006418)3.53675114
38establishment of viral latency (GO:0019043)3.52763316
39muscle filament sliding (GO:0030049)3.46897989
40actin-myosin filament sliding (GO:0033275)3.46897989
41tRNA aminoacylation (GO:0043039)3.46395033
42amino acid activation (GO:0043038)3.46395033
43formation of translation preinitiation complex (GO:0001731)3.44798792
44DNA damage response, detection of DNA damage (GO:0042769)3.43337981
45proton transport (GO:0015992)3.41114896
46heart contraction (GO:0060047)3.38905977
47heart process (GO:0003015)3.38905977
48CENP-A containing nucleosome assembly (GO:0034080)3.37277385
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.36154194
50negative regulation of ligase activity (GO:0051352)3.35546380
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35546380
52regulation of cellular amino acid metabolic process (GO:0006521)3.34922356
53hydrogen transport (GO:0006818)3.33752784
54chromatin remodeling at centromere (GO:0031055)3.32684345
55regulation of mitochondrial translation (GO:0070129)3.31932044
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31668456
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30081784
58cardiac myofibril assembly (GO:0055003)3.29688130
59ribonucleoside monophosphate biosynthetic process (GO:0009156)3.28625635
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.25543316
61positive regulation of ligase activity (GO:0051351)3.24738425
62DNA strand elongation involved in DNA replication (GO:0006271)3.23277483
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23153101
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23153101
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22707409
66regulation of ubiquitin-protein transferase activity (GO:0051438)3.19888904
67nucleobase-containing small molecule interconversion (GO:0015949)3.19686955
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19337878
69GTP biosynthetic process (GO:0006183)3.19324454
70glycolytic process (GO:0006096)3.16915944
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16645312
72establishment of protein localization to mitochondrion (GO:0072655)3.13819890
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13560869
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13560869
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13560869
76DNA strand elongation (GO:0022616)3.12399976
77aerobic respiration (GO:0009060)3.11532997
78mitotic metaphase plate congression (GO:0007080)3.10662308
79protein localization to mitochondrion (GO:0070585)3.09925306
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.09636216
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09636216
82succinate metabolic process (GO:0006105)3.09083370
83UTP biosynthetic process (GO:0006228)3.07722934
84DNA replication checkpoint (GO:0000076)3.07593556
85chaperone-mediated protein complex assembly (GO:0051131)3.06967002
86telomere maintenance via semi-conservative replication (GO:0032201)3.06876564
87regulation of ligase activity (GO:0051340)3.06149026
88mitochondrial transport (GO:0006839)3.05420573
89nucleoside monophosphate biosynthetic process (GO:0009124)3.04255599
90translational termination (GO:0006415)3.03936702
91signal transduction involved in cell cycle checkpoint (GO:0072395)3.02498912
92de novo protein folding (GO:0006458)3.02152273
93IMP metabolic process (GO:0046040)3.02111939
94protein targeting to mitochondrion (GO:0006626)3.01790452
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01323739
96protein maturation by protein folding (GO:0022417)3.00465749
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00367333
98viral transcription (GO:0019083)2.99659324
99ribosomal large subunit biogenesis (GO:0042273)2.99510668
100nucleobase biosynthetic process (GO:0046112)2.98309368
101translational elongation (GO:0006414)2.97642430
102chaperone-mediated protein transport (GO:0072321)2.96776054
103oxaloacetate metabolic process (GO:0006107)2.96415849
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95619003
105L-serine metabolic process (GO:0006563)2.95358082
106termination of RNA polymerase III transcription (GO:0006386)2.95245039
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.95245039
108ribosome biogenesis (GO:0042254)2.93446692
109purine nucleobase biosynthetic process (GO:0009113)2.91010314
110rRNA modification (GO:0000154)2.90789197
111de novo posttranslational protein folding (GO:0051084)2.90523242
112guanosine-containing compound biosynthetic process (GO:1901070)2.89401294
113proteasome assembly (GO:0043248)2.89100074
114maturation of SSU-rRNA (GO:0030490)2.88331482
115ubiquinone biosynthetic process (GO:0006744)2.86277099
116quinone biosynthetic process (GO:1901663)2.86277099
117establishment of integrated proviral latency (GO:0075713)2.85842189
118IMP biosynthetic process (GO:0006188)2.85454528
119UTP metabolic process (GO:0046051)2.84856652
120mitochondrial fusion (GO:0008053)2.84673029
121DNA unwinding involved in DNA replication (GO:0006268)2.84315595
122regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.84042393
123mitochondrial RNA metabolic process (GO:0000959)2.80752625
124spliceosomal snRNP assembly (GO:0000387)2.79882045
125peptidyl-histidine modification (GO:0018202)2.72917857
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72017507
127transcription from mitochondrial promoter (GO:0006390)2.71628158
128G1/S transition of mitotic cell cycle (GO:0000082)2.71050348
129cell cycle G1/S phase transition (GO:0044843)2.71050348
130mitotic sister chromatid segregation (GO:0000070)2.70456218
131histone exchange (GO:0043486)2.70311615
132deoxyribonucleotide biosynthetic process (GO:0009263)2.70119305
133ventricular cardiac muscle cell development (GO:0055015)2.68055348
134ribonucleoprotein complex biogenesis (GO:0022613)2.66731867
135DNA ligation (GO:0006266)2.65632098
136DNA replication-independent nucleosome assembly (GO:0006336)2.65123547
137DNA replication-independent nucleosome organization (GO:0034724)2.65123547
138metaphase plate congression (GO:0051310)2.64819763
139maturation of 5.8S rRNA (GO:0000460)2.63205949
140protein localization to kinetochore (GO:0034501)2.62726015
141negative regulation of protein ubiquitination (GO:0031397)2.62690117
142regulation of translational fidelity (GO:0006450)2.60230043
143regulation of cellular amine metabolic process (GO:0033238)2.60207455
144translation (GO:0006412)2.60128518
145ribonucleoprotein complex disassembly (GO:0032988)2.59998552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.70790879
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38667773
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.36462661
4E2F7_22180533_ChIP-Seq_HELA_Human4.22279821
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.79920532
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.72136457
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.63964223
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42601233
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.40889147
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.32281226
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.07557117
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07125169
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.06613903
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04417613
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94740006
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88406054
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86916403
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.64734486
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64585525
20* DCP1A_22483619_ChIP-Seq_HELA_Human2.58457980
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44175852
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43563335
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36622764
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35918040
25XRN2_22483619_ChIP-Seq_HELA_Human2.33359691
26* VDR_23849224_ChIP-Seq_CD4+_Human2.24939433
27AR_21909140_ChIP-Seq_LNCAP_Human2.19658082
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.14090954
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.13846091
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03127971
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01735248
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01168372
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.99085875
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98727145
35* GABP_19822575_ChIP-Seq_HepG2_Human1.97802301
36ELK1_19687146_ChIP-ChIP_HELA_Human1.96808908
37TTF2_22483619_ChIP-Seq_HELA_Human1.95159277
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95036857
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91517984
40FOXP3_21729870_ChIP-Seq_TREG_Human1.82259022
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82117196
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70231835
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69858120
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65404575
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.64129690
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63435062
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59769719
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57217675
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51265349
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50688582
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45962841
52CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.45318356
53BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42322100
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40004286
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39652717
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34090536
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.31094932
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30418456
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30311818
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29132141
61TFEB_21752829_ChIP-Seq_HELA_Human1.24936752
62ZNF263_19887448_ChIP-Seq_K562_Human1.24694363
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20721090
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18791847
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17810911
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16570678
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15839037
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14325899
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.13799810
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13691998
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13203502
72KDM5A_27292631_Chip-Seq_BREAST_Human1.12369590
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.12051410
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12049954
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10665448
76MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10144350
77* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09868036
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.09574424
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.08491511
80* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08070726
81GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07504009
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04614158
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04310197
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03005880
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02994695
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02106141
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99998878
88TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99365113
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99091961
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97975079
91* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97458350
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96393061
93CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96148809
94HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95717835
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93944275
96MYC_18940864_ChIP-ChIP_HL60_Human0.93762531
97VDR_22108803_ChIP-Seq_LS180_Human0.93332103
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93181069
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90739256
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89415831
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89126851
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88924967
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88250846
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87988605
105* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87977503
106SOX2_16153702_ChIP-ChIP_HESCs_Human0.87597445
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86818450
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85576930
109ELF5_23300383_ChIP-Seq_T47D_Human0.84836216
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84120211
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83372163
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79998519
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.75793449
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75664513
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74778927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.11494929
2MP0002837_dystrophic_cardiac_calcinosis4.02732050
3MP0004215_abnormal_myocardial_fiber3.69729547
4MP0004036_abnormal_muscle_relaxation3.69712685
5MP0000751_myopathy3.63644990
6MP0003646_muscle_fatigue3.50314671
7MP0000749_muscle_degeneration3.34995642
8MP0006036_abnormal_mitochondrial_physio3.03946158
9MP0004957_abnormal_blastocyst_morpholog2.72364924
10MP0005330_cardiomyopathy2.61848022
11MP0004233_abnormal_muscle_weight2.52386210
12MP0003941_abnormal_skin_development2.48414869
13MP0005410_abnormal_fertilization2.40199051
14MP0002972_abnormal_cardiac_muscle2.39375908
15MP0003221_abnormal_cardiomyocyte_apopto2.35547772
16MP0003950_abnormal_plasma_membrane2.34015656
17MP0008775_abnormal_heart_ventricle2.30859370
18MP0000750_abnormal_muscle_regeneration2.22576599
19MP0003693_abnormal_embryo_hatching2.07878032
20MP0004087_abnormal_muscle_fiber2.05786886
21MP0006035_abnormal_mitochondrial_morpho2.05763898
22MP0002332_abnormal_exercise_endurance1.99967981
23MP0005620_abnormal_muscle_contractility1.97717492
24MP0003718_maternal_effect1.94515039
25MP0004484_altered_response_of1.93136459
26MP0000372_irregular_coat_pigmentation1.90435264
27MP0005385_cardiovascular_system_phenoty1.88729474
28MP0001544_abnormal_cardiovascular_syste1.88729474
29MP0003806_abnormal_nucleotide_metabolis1.84781741
30MP0003123_paternal_imprinting1.82556689
31MP0002106_abnormal_muscle_physiology1.77065348
32MP0006138_congestive_heart_failure1.76078345
33MP0000747_muscle_weakness1.71669294
34MP0002269_muscular_atrophy1.69658853
35MP0003890_abnormal_embryonic-extraembry1.64854397
36MP0005266_abnormal_metabolism1.62841046
37MP0008932_abnormal_embryonic_tissue1.62572467
38MP0004145_abnormal_muscle_electrophysio1.56176420
39MP0003137_abnormal_impulse_conducting1.51470549
40MP0010094_abnormal_chromosome_stability1.50914985
41MP0003567_abnormal_fetal_cardiomyocyte1.48762957
42MP0001730_embryonic_growth_arrest1.48718179
43MP0003077_abnormal_cell_cycle1.48685199
44MP0010630_abnormal_cardiac_muscle1.48120039
45MP0001529_abnormal_vocalization1.47347946
46MP0005623_abnormal_meninges_morphology1.47321135
47MP0008004_abnormal_stomach_pH1.45680415
48MP0000358_abnormal_cell_content/1.40512669
49MP0010030_abnormal_orbit_morphology1.34909746
50MP0006054_spinal_hemorrhage1.34533827
51MP0002102_abnormal_ear_morphology1.31094055
52MP0005369_muscle_phenotype1.29206628
53MP0000759_abnormal_skeletal_muscle1.29157557
54MP0003122_maternal_imprinting1.28735147
55MP0001727_abnormal_embryo_implantation1.22005202
56MP0003186_abnormal_redox_activity1.20364367
57MP0004085_abnormal_heartbeat1.19063976
58MP0002084_abnormal_developmental_patter1.18660201
59MP0003315_abnormal_perineum_morphology1.16822183
60MP0003111_abnormal_nucleus_morphology1.16353137
61MP0009672_abnormal_birth_weight1.14486592
62MP0005501_abnormal_skin_physiology1.13415843
63MP0003828_pulmonary_edema1.13203549
64MP0003878_abnormal_ear_physiology1.12653422
65MP0005377_hearing/vestibular/ear_phenot1.12653422
66MP0004272_abnormal_basement_membrane1.12031706
67MP0006292_abnormal_olfactory_placode1.11962061
68MP0002127_abnormal_cardiovascular_syste1.11065714
69MP0003937_abnormal_limbs/digits/tail_de1.10527478
70MP0000647_abnormal_sebaceous_gland1.10070478
71MP0004043_abnormal_pH_regulation1.09936642
72MP0004147_increased_porphyrin_level1.09589388
73MP0008877_abnormal_DNA_methylation1.08549895
74MP0001188_hyperpigmentation1.07671523
75MP0008995_early_reproductive_senescence1.07063779
76MP0001293_anophthalmia1.06164205
77MP0002938_white_spotting1.06080333
78MP0001697_abnormal_embryo_size1.05091562
79MP0002796_impaired_skin_barrier1.02414271
80MP0001661_extended_life_span1.01538940
81MP0008789_abnormal_olfactory_epithelium1.01237398
82MP0004130_abnormal_muscle_cell1.00837228
83MP0000343_altered_response_to0.99066329
84MP0005165_increased_susceptibility_to0.98614231
85MP0002210_abnormal_sex_determination0.97287072
86MP0010234_abnormal_vibrissa_follicle0.96184394
87MP0003984_embryonic_growth_retardation0.95163075
88MP0005394_taste/olfaction_phenotype0.94905447
89MP0005499_abnormal_olfactory_system0.94905447
90MP0006276_abnormal_autonomic_nervous0.93306290
91MP0008058_abnormal_DNA_repair0.92803825
92MP0002234_abnormal_pharynx_morphology0.91420465
93MP0002080_prenatal_lethality0.91145554
94MP0002088_abnormal_embryonic_growth/wei0.89995479
95MP0005187_abnormal_penis_morphology0.89857916
96MP0000537_abnormal_urethra_morphology0.88681663
97MP0005367_renal/urinary_system_phenotyp0.86589890
98MP0000516_abnormal_urinary_system0.86589890
99MP0008007_abnormal_cellular_replicative0.86499507
100MP0009379_abnormal_foot_pigmentation0.85356001
101MP0009046_muscle_twitch0.85151769
102MP0000350_abnormal_cell_proliferation0.84986335
103MP0002090_abnormal_vision0.84454153
104MP0000013_abnormal_adipose_tissue0.83959887
105MP0004197_abnormal_fetal_growth/weight/0.83662933
106MP0003385_abnormal_body_wall0.81818189
107MP0005380_embryogenesis_phenotype0.81200112
108MP0001672_abnormal_embryogenesis/_devel0.81200112
109MP0010352_gastrointestinal_tract_polyps0.80802214
110MP0003119_abnormal_digestive_system0.80541676
111MP0005376_homeostasis/metabolism_phenot0.80260137
112MP0006072_abnormal_retinal_apoptosis0.79029296
113MP0000579_abnormal_nail_morphology0.78941771
114MP0002233_abnormal_nose_morphology0.78855929
115MP0001984_abnormal_olfaction0.77609527
116MP0003698_abnormal_male_reproductive0.77324638
117MP0003566_abnormal_cell_adhesion0.77020889
118MP0002086_abnormal_extraembryonic_tissu0.75707203
119MP0001905_abnormal_dopamine_level0.74895174
120MP0005408_hypopigmentation0.74777222
121MP0001145_abnormal_male_reproductive0.74601271
122MP0003786_premature_aging0.71689005
123MP0002697_abnormal_eye_size0.70741735
124MP0001286_abnormal_eye_development0.70543587
125MP0000266_abnormal_heart_morphology0.70437853
126MP0008057_abnormal_DNA_replication0.69875186
127MP0010307_abnormal_tumor_latency0.68834933
128MP0001929_abnormal_gametogenesis0.68489567
129MP0002736_abnormal_nociception_after0.67099157
130MP0009697_abnormal_copulation0.65245029
131MP0000313_abnormal_cell_death0.63134291
132MP0001664_abnormal_digestion0.60400535
133MP0003121_genomic_imprinting0.60078390
134MP0001440_abnormal_grooming_behavior0.55403827
135MP0001485_abnormal_pinna_reflex0.55160527
136MP0003880_abnormal_central_pattern0.54146218
137MP0000230_abnormal_systemic_arterial0.53428435
138MP0002160_abnormal_reproductive_system0.52030757
139MP0004133_heterotaxia0.50689387
140MP0004142_abnormal_muscle_tone0.50445791
141MP0002085_abnormal_embryonic_tissue0.49545072
142MP0000490_abnormal_crypts_of0.49482436

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.51635151
2Abnormal mitochondria in muscle tissue (HP:0008316)6.35243625
3Abnormality of glycolysis (HP:0004366)5.67736060
4Increased serum pyruvate (HP:0003542)5.67736060
5Mitochondrial inheritance (HP:0001427)5.56162182
6Progressive macrocephaly (HP:0004481)5.41538382
7Hepatocellular necrosis (HP:0001404)5.25629458
8Acute encephalopathy (HP:0006846)5.25382374
9Increased CSF lactate (HP:0002490)5.20279039
10Exercise-induced muscle cramps (HP:0003710)4.97455140
11Hepatic necrosis (HP:0002605)4.81869356
12Respiratory failure (HP:0002878)4.09773821
13Exercise intolerance (HP:0003546)4.09378425
14Sudden death (HP:0001699)3.97307026
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74176005
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74176005
17Palpitations (HP:0001962)3.72975615
18Lactic acidosis (HP:0003128)3.62842119
19Rhabdomyolysis (HP:0003201)3.59338623
20Myoglobinuria (HP:0002913)3.56177536
21Cerebral edema (HP:0002181)3.55217060
22Increased serum lactate (HP:0002151)3.50659420
23Neuroendocrine neoplasm (HP:0100634)3.39965648
24Leukodystrophy (HP:0002415)3.31070051
25Increased hepatocellular lipid droplets (HP:0006565)3.30387558
26Pheochromocytoma (HP:0002666)3.29802228
27Ventricular tachycardia (HP:0004756)3.24672312
28Lipid accumulation in hepatocytes (HP:0006561)3.22398243
29Increased intramyocellular lipid droplets (HP:0012240)3.22100553
30Conjunctival hamartoma (HP:0100780)3.19107625
31Calf muscle hypertrophy (HP:0008981)3.15145103
32Muscle hypertrophy of the lower extremities (HP:0008968)3.11625619
33Increased muscle lipid content (HP:0009058)3.11077941
34Exercise-induced myalgia (HP:0003738)3.10449520
35Optic disc pallor (HP:0000543)3.09754066
36Abnormality of alanine metabolism (HP:0010916)3.05847621
37Hyperalaninemia (HP:0003348)3.05847621
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.05847621
39Emotional lability (HP:0000712)2.87909545
40Ragged-red muscle fibers (HP:0003200)2.84902513
41Lipoatrophy (HP:0100578)2.82397703
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82150657
43CNS demyelination (HP:0007305)2.80636926
44Abnormality of the calf musculature (HP:0001430)2.77637870
45Muscle fiber splitting (HP:0003555)2.75409490
46Abnormality of cells of the erythroid lineage (HP:0012130)2.62506626
47Atrial fibrillation (HP:0005110)2.53130437
48Abnormality of methionine metabolism (HP:0010901)2.51168967
49Neoplasm of head and neck (HP:0012288)2.49965743
50Esophageal neoplasm (HP:0100751)2.49965743
51Abnormal number of erythroid precursors (HP:0012131)2.42973228
52Type I transferrin isoform profile (HP:0003642)2.42065095
53Supraventricular tachycardia (HP:0004755)2.41723085
54EMG: myopathic abnormalities (HP:0003458)2.38653920
55Cortical dysplasia (HP:0002539)2.38642040
56Supraventricular arrhythmia (HP:0005115)2.37890175
57Shoulder girdle muscle weakness (HP:0003547)2.36964594
58Primary atrial arrhythmia (HP:0001692)2.36119427
59Abnormality of the vocal cords (HP:0008777)2.32483700
60Neoplasm of the adrenal gland (HP:0100631)2.32280253
61Respiratory difficulties (HP:0002880)2.30894337
62Myotonia (HP:0002486)2.30305672
63Abnormality of the labia minora (HP:0012880)2.27767888
64Muscle stiffness (HP:0003552)2.23566174
65Neoplasm of the peripheral nervous system (HP:0100007)2.22274615
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18660420
67Abnormality of serum amino acid levels (HP:0003112)2.18251885
68Dilated cardiomyopathy (HP:0001644)2.17073147
69Gliosis (HP:0002171)2.15159634
70Right ventricular cardiomyopathy (HP:0011663)2.14001392
71Athetosis (HP:0002305)2.13751889
72Syncope (HP:0001279)2.12478357
73Angiofibromas (HP:0010615)2.10514200
74Adenoma sebaceum (HP:0009720)2.10514200
75Multiple enchondromatosis (HP:0005701)2.09873031
76Birth length less than 3rd percentile (HP:0003561)2.08336601
77Abnormal gallbladder physiology (HP:0012438)2.07643747
78Cholecystitis (HP:0001082)2.07643747
79Abnormal protein glycosylation (HP:0012346)2.06162381
80Abnormal glycosylation (HP:0012345)2.06162381
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06162381
82Abnormal protein N-linked glycosylation (HP:0012347)2.06162381
83Amniotic constriction ring (HP:0009775)2.04904793
84Abnormality of placental membranes (HP:0011409)2.04904793
85Reduced antithrombin III activity (HP:0001976)2.04662578
86Progressive muscle weakness (HP:0003323)2.03998916
87Atrophy/Degeneration involving motor neurons (HP:0007373)2.02051075
88X-linked dominant inheritance (HP:0001423)2.00494013
89CNS hypomyelination (HP:0003429)1.98948524
90Hyperglycinemia (HP:0002154)1.98163945
91Exertional dyspnea (HP:0002875)1.97559606
92Renal Fanconi syndrome (HP:0001994)1.97067616
93Ependymoma (HP:0002888)1.93133603
94Abnormal lung lobation (HP:0002101)1.92896662
95Hypoglycemic coma (HP:0001325)1.92835821
96Postnatal microcephaly (HP:0005484)1.90384874
97Hyporeflexia of lower limbs (HP:0002600)1.88659392
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87507226
99Methylmalonic acidemia (HP:0002912)1.86222630
100Neck muscle weakness (HP:0000467)1.85326565
101Reticulocytopenia (HP:0001896)1.85136716
102Neoplasm of the rectum (HP:0100743)1.84979754
103Agnosia (HP:0010524)1.84946079
104Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84288306
105Cerebral hypomyelination (HP:0006808)1.83569901
106Left ventricular hypertrophy (HP:0001712)1.83507352
107Delayed gross motor development (HP:0002194)1.82828210
108Abnormality of the left ventricular outflow tract (HP:0011103)1.82779651
109Subaortic stenosis (HP:0001682)1.82779651
110Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.82027245
111Sparse eyelashes (HP:0000653)1.81384229
112Abnormality of the musculature of the pelvis (HP:0001469)1.80311661
113Abnormality of the hip-girdle musculature (HP:0001445)1.80311661
114Chromsome breakage (HP:0040012)1.79815276
115Muscle fiber inclusion bodies (HP:0100299)1.79076939
116Nausea (HP:0002018)1.77781371
1173-Methylglutaconic aciduria (HP:0003535)1.77533430
118Methylmalonic aciduria (HP:0012120)1.76845628
119Upper limb muscle weakness (HP:0003484)1.76363654
120Asymmetric septal hypertrophy (HP:0001670)1.76135713
121Pelvic girdle muscle weakness (HP:0003749)1.75806820
122Abnormalities of placenta or umbilical cord (HP:0001194)1.74767706
123Rimmed vacuoles (HP:0003805)1.74033685
124Respiratory insufficiency due to muscle weakness (HP:0002747)1.72943087
125Ventricular arrhythmia (HP:0004308)1.72518402
126Secondary amenorrhea (HP:0000869)1.72152268
127Abnormality of the umbilical cord (HP:0010881)1.71937172
128Abnormality of the anterior horn cell (HP:0006802)1.71057026
129Degeneration of anterior horn cells (HP:0002398)1.71057026
130Prolonged QT interval (HP:0001657)1.69050097
131Microvesicular hepatic steatosis (HP:0001414)1.68590056
132Poor suck (HP:0002033)1.67132669
133Trismus (HP:0000211)1.65899323
134Gout (HP:0001997)1.64357068
135Hypoplastic pelvis (HP:0008839)1.64209931
136Nemaline bodies (HP:0003798)1.63073531
137Lethargy (HP:0001254)1.62525467
138Hypoplastic left heart (HP:0004383)1.62360712
139Generalized aminoaciduria (HP:0002909)1.58821447
140Abnormal umbilical cord blood vessels (HP:0011403)1.58732948
141Single umbilical artery (HP:0001195)1.58732948
142Abnormality of the fetal cardiovascular system (HP:0010948)1.58732948
143Abnormality of the preputium (HP:0100587)1.58394920
144Meckel diverticulum (HP:0002245)1.57524064
145Abnormality of serine family amino acid metabolism (HP:0010894)1.54147651
146Abnormality of glycine metabolism (HP:0010895)1.54147651
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.54055683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.70971530
2PDK34.70971530
3NEK13.81032934
4PDK22.95843268
5TESK12.91697306
6TRIM282.89133456
7NME22.85522876
8BUB12.76868351
9MYLK2.74411973
10NME12.70437780
11EIF2AK12.62469697
12OBSCN2.23974354
13WEE12.21178162
14MST42.20779447
15VRK22.16774828
16TTN2.15719603
17LIMK12.10730939
18MAP3K122.09701774
19TSSK61.97837830
20LMTK21.76820914
21CCNB11.76611676
22TESK21.68797636
23PBK1.67135889
24ERBB31.48030914
25SCYL21.42072704
26PKN21.41881608
27PAK41.40845541
28ILK1.39451204
29CDC71.36401691
30ARAF1.35550316
31CSNK1G31.23973758
32EIF2AK31.16412896
33PLK21.11989859
34PTK2B1.11865006
35STK391.09970403
36STK241.08418782
37PIM21.08339085
38CSNK1G11.06869445
39WNK41.04603010
40PLK31.04091236
41BRSK11.03236509
42MAP4K21.02264690
43DAPK31.01976347
44CSNK1A1L1.00962076
45TTK0.98361622
46ERBB40.98288322
47CSNK1G20.96964664
48WNK30.95762182
49PHKG20.95706060
50PHKG10.95706060
51CASK0.95490688
52BRAF0.95318467
53NEK90.93284356
54MAP2K70.92668044
55BCKDK0.91667695
56MKNK20.85657935
57BRSK20.84082367
58CHEK20.80931887
59MAP3K110.79844441
60EIF2AK20.78940563
61ATR0.78674606
62CDK190.77962646
63STK160.77919202
64VRK10.76615009
65PAK10.71974210
66RPS6KA40.70576090
67PASK0.70200810
68DYRK20.70073903
69PLK10.69963324
70SIK30.66913457
71NEK20.65898620
72GRK70.65246558
73TLK10.65000013
74MST1R0.64926448
75STK38L0.62232950
76BMPR1B0.62197281
77AURKB0.62061489
78OXSR10.61866498
79PRKG20.61542667
80NUAK10.61439218
81AURKA0.61285200
82CHEK10.60648398
83CAMK2D0.59869232
84CDK140.59158493
85MAP3K80.58864810
86PNCK0.57862138
87FLT30.57285011
88BCR0.56866730
89CDK70.55949635
90LRRK20.55708797
91STK40.53523463
92ATM0.53506003
93ROCK20.52358531
94DMPK0.51826462
95DYRK30.50078970
96RPS6KB20.50029489
97TAF10.49381084
98MET0.48753295
99PIK3CA0.46237954
100ACVR1B0.45904195
101SRPK10.45805884
102MAP3K50.45256508
103CSNK1E0.44899358
104GRK50.43493488
105CDK180.42942942
106CSNK2A10.42592172
107MAP2K30.42374755
108MKNK10.42135907
109CDK150.40700371
110CSNK2A20.39457652
111MAP3K30.39109196
112EPHA20.38722652
113ABL20.37776804
114MAPKAPK30.37653363
115MAP3K40.37622101
116MAPKAPK50.37117929
117ALK0.36986899
118DAPK10.36630040
119CDK80.34946466
120PLK40.34133026
121CDK11A0.34032009
122ZAK0.32642062
123MINK10.32087071
124MUSK0.29231349
125CAMK2A0.29128478
126PRKD30.28852027
127KDR0.28207080
128CAMK2G0.27822005
129ADRBK10.26422362
130CAMK2B0.25918327
131AKT20.25362626
132TRIB30.23999837

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.25580956
2Oxidative phosphorylation_Homo sapiens_hsa001905.03863933
3Parkinsons disease_Homo sapiens_hsa050124.43980304
4Proteasome_Homo sapiens_hsa030503.90961496
5Huntingtons disease_Homo sapiens_hsa050163.27300682
6Alzheimers disease_Homo sapiens_hsa050103.16254059
7Cardiac muscle contraction_Homo sapiens_hsa042603.00248041
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73601548
9Ribosome_Homo sapiens_hsa030102.65254656
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.50656792
11Carbon metabolism_Homo sapiens_hsa012002.30631366
12Pyruvate metabolism_Homo sapiens_hsa006202.21759307
13Collecting duct acid secretion_Homo sapiens_hsa049662.21215783
14DNA replication_Homo sapiens_hsa030302.16825511
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.10417535
16Mismatch repair_Homo sapiens_hsa034301.85089379
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85020657
18RNA polymerase_Homo sapiens_hsa030201.77065268
19Vibrio cholerae infection_Homo sapiens_hsa051101.57488374
20Steroid biosynthesis_Homo sapiens_hsa001001.51391118
21RNA transport_Homo sapiens_hsa030131.49583202
22Propanoate metabolism_Homo sapiens_hsa006401.48510544
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46575806
24Biosynthesis of amino acids_Homo sapiens_hsa012301.42833087
25Nucleotide excision repair_Homo sapiens_hsa034201.37665845
26Spliceosome_Homo sapiens_hsa030401.34546640
27Pyrimidine metabolism_Homo sapiens_hsa002401.21388611
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19033978
29Fructose and mannose metabolism_Homo sapiens_hsa000511.18017245
30Protein export_Homo sapiens_hsa030601.14037329
31Folate biosynthesis_Homo sapiens_hsa007901.13302400
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11697635
33Vitamin B6 metabolism_Homo sapiens_hsa007501.04349347
34Sulfur relay system_Homo sapiens_hsa041221.00803317
35Synaptic vesicle cycle_Homo sapiens_hsa047211.00794717
36Pentose phosphate pathway_Homo sapiens_hsa000300.97421839
37Dilated cardiomyopathy_Homo sapiens_hsa054140.97135355
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95818368
39Base excision repair_Homo sapiens_hsa034100.93915561
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91135020
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.89041234
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88340753
43Purine metabolism_Homo sapiens_hsa002300.87180551
44Selenocompound metabolism_Homo sapiens_hsa004500.86818834
45Basal transcription factors_Homo sapiens_hsa030220.83193477
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82524674
47Homologous recombination_Homo sapiens_hsa034400.78606878
48Phagosome_Homo sapiens_hsa041450.78017445
49Glutathione metabolism_Homo sapiens_hsa004800.76331078
50Galactose metabolism_Homo sapiens_hsa000520.75063237
51Cell cycle_Homo sapiens_hsa041100.74306192
52RNA degradation_Homo sapiens_hsa030180.71142406
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68667720
54Legionellosis_Homo sapiens_hsa051340.68094372
55Fatty acid elongation_Homo sapiens_hsa000620.67765151
56Oocyte meiosis_Homo sapiens_hsa041140.67223311
57One carbon pool by folate_Homo sapiens_hsa006700.64356530
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62593014
59HIF-1 signaling pathway_Homo sapiens_hsa040660.59822049
60Butanoate metabolism_Homo sapiens_hsa006500.59394403
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59043616
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58808233
63Renin-angiotensin system_Homo sapiens_hsa046140.58523555
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57611434
65Metabolic pathways_Homo sapiens_hsa011000.56686693
66Peroxisome_Homo sapiens_hsa041460.55107982
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54983331
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54934040
69Arginine biosynthesis_Homo sapiens_hsa002200.54816051
70Rheumatoid arthritis_Homo sapiens_hsa053230.53113859
71N-Glycan biosynthesis_Homo sapiens_hsa005100.51875273
72Epstein-Barr virus infection_Homo sapiens_hsa051690.51037158
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50608934
74Mineral absorption_Homo sapiens_hsa049780.44501824
75Tight junction_Homo sapiens_hsa045300.43640632
76Phenylalanine metabolism_Homo sapiens_hsa003600.43610496
77beta-Alanine metabolism_Homo sapiens_hsa004100.41223377
78Sulfur metabolism_Homo sapiens_hsa009200.40984324
79mRNA surveillance pathway_Homo sapiens_hsa030150.40210965
80Viral myocarditis_Homo sapiens_hsa054160.40068963
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36625171
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36005116
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35516894
84Fatty acid degradation_Homo sapiens_hsa000710.33980889
85Glucagon signaling pathway_Homo sapiens_hsa049220.33138367
86Systemic lupus erythematosus_Homo sapiens_hsa053220.32614569
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32422316
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.32356540
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31749917
90Non-homologous end-joining_Homo sapiens_hsa034500.31632695
91Fatty acid metabolism_Homo sapiens_hsa012120.30837883
92Tyrosine metabolism_Homo sapiens_hsa003500.30485668
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28445280
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27989658
95Regulation of autophagy_Homo sapiens_hsa041400.27920174
96Fat digestion and absorption_Homo sapiens_hsa049750.27346576
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.27130722
98Alcoholism_Homo sapiens_hsa050340.25209762
99Fanconi anemia pathway_Homo sapiens_hsa034600.24846743
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24627535
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23518219
102Hippo signaling pathway_Homo sapiens_hsa043900.23018643
103Arginine and proline metabolism_Homo sapiens_hsa003300.22064182
104Viral carcinogenesis_Homo sapiens_hsa052030.21487369
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21015050
106Salmonella infection_Homo sapiens_hsa051320.16726794
107Thyroid cancer_Homo sapiens_hsa052160.16199719
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.15505678
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.15352629
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14429520
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14190481
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14068473
113TGF-beta signaling pathway_Homo sapiens_hsa043500.13118289
114Starch and sucrose metabolism_Homo sapiens_hsa005000.12439663
115Gastric acid secretion_Homo sapiens_hsa049710.11439157
116Shigellosis_Homo sapiens_hsa051310.11322920
117* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11070321
118Circadian rhythm_Homo sapiens_hsa047100.10872654
119Tryptophan metabolism_Homo sapiens_hsa003800.10150425
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09323675
121Dopaminergic synapse_Homo sapiens_hsa047280.09298308
122Renin secretion_Homo sapiens_hsa049240.08201199
123Antigen processing and presentation_Homo sapiens_hsa046120.06120382
124p53 signaling pathway_Homo sapiens_hsa041150.05738935
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04741182
126Long-term potentiation_Homo sapiens_hsa047200.00703032
127Gap junction_Homo sapiens_hsa045400.00694527

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