VDAC2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mast cell activation (GO:0033004)6.07898350
2tyrosine phosphorylation of STAT protein (GO:0007260)5.94166713
3interleukin-6-mediated signaling pathway (GO:0070102)5.46115700
4auditory behavior (GO:0031223)5.39944514
5righting reflex (GO:0060013)5.32835251
6water-soluble vitamin biosynthetic process (GO:0042364)5.26344965
7regulation of nuclear cell cycle DNA replication (GO:0033262)5.15769834
8regulation of cytokine production involved in inflammatory response (GO:1900015)5.13925026
9short-chain fatty acid metabolic process (GO:0046459)4.92430468
10multicellular organism reproduction (GO:0032504)4.80015215
11DNA deamination (GO:0045006)4.69096252
12positive regulation of T cell cytokine production (GO:0002726)4.56610980
13DNA double-strand break processing (GO:0000729)4.54965298
14protein K11-linked deubiquitination (GO:0035871)4.46361387
15mechanosensory behavior (GO:0007638)4.16232671
16positive regulation of osteoclast differentiation (GO:0045672)4.15698818
17apoptotic DNA fragmentation (GO:0006309)4.09549976
18protein import into peroxisome matrix (GO:0016558)4.06807698
19transcription elongation from RNA polymerase I promoter (GO:0006362)4.03723067
20peptidyl-histidine modification (GO:0018202)4.03378676
21behavioral response to nicotine (GO:0035095)3.88099796
22neuronal action potential propagation (GO:0019227)3.84972092
23negative regulation of metanephros development (GO:0072217)3.83022830
24presynaptic membrane organization (GO:0097090)3.64772936
25termination of RNA polymerase I transcription (GO:0006363)3.62400367
26protein localization to synapse (GO:0035418)3.60407463
27regulation of immunoglobulin secretion (GO:0051023)3.44721571
28detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.40809115
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31303420
30regulation of interleukin-6 biosynthetic process (GO:0045408)3.29085506
31presynaptic membrane assembly (GO:0097105)3.27844674
32otic vesicle formation (GO:0030916)3.24503968
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.22125712
34positive regulation of transcription regulatory region DNA binding (GO:2000679)3.17291281
35cullin deneddylation (GO:0010388)3.16591457
36negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.16399180
37positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12730191
38transcription initiation from RNA polymerase I promoter (GO:0006361)3.08811485
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08333131
40parental behavior (GO:0060746)3.04229398
41protein deneddylation (GO:0000338)3.03313830
42rRNA catabolic process (GO:0016075)3.02521655
43detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.02447619
44regulation of DNA endoreduplication (GO:0032875)3.01652704
45regulation of telomere maintenance (GO:0032204)3.00637764
46negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.98119816
47smooth muscle tissue development (GO:0048745)2.97621192
48regulation of interleukin-12 biosynthetic process (GO:0045075)2.96954895
49negative regulation of telomere maintenance (GO:0032205)2.93486731
50response to auditory stimulus (GO:0010996)2.93358518
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91175271
52biotin metabolic process (GO:0006768)2.88712685
53pyrimidine dimer repair (GO:0006290)2.88615018
54positive regulation of T-helper 1 type immune response (GO:0002827)2.87161808
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.86841614
56NADH dehydrogenase complex assembly (GO:0010257)2.86841614
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86841614
58reproduction (GO:0000003)2.83756730
59protein autoubiquitination (GO:0051865)2.83750515
60adaptation of signaling pathway (GO:0023058)2.81910706
61regulation of T cell cytokine production (GO:0002724)2.76495878
62respiratory chain complex IV assembly (GO:0008535)2.75986235
63positive regulation of defense response to virus by host (GO:0002230)2.73825287
64cerebral cortex radially oriented cell migration (GO:0021799)2.71550434
65base-excision repair, AP site formation (GO:0006285)2.70309535
66DNA catabolic process, exonucleolytic (GO:0000738)2.68825448
67protein targeting to vacuole (GO:0006623)2.68182713
68protein targeting to lysosome (GO:0006622)2.68182713
69establishment of protein localization to vacuole (GO:0072666)2.68182713
70positive regulation of amino acid transport (GO:0051957)2.67820134
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67192757
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67150565
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65197432
74regulation of male gonad development (GO:2000018)2.64269653
75phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62728442
76nucleotide-excision repair, DNA gap filling (GO:0006297)2.61604056
77protein localization to lysosome (GO:0061462)2.61567123
78protein localization to vacuole (GO:0072665)2.61567123
79piRNA metabolic process (GO:0034587)2.61148785
80DNA demethylation (GO:0080111)2.61090695
81positive regulation of synapse assembly (GO:0051965)2.59506599
82negative regulation of cell cycle arrest (GO:0071157)2.57263751
83mitochondrial respiratory chain complex assembly (GO:0033108)2.55491440
84replication fork processing (GO:0031297)2.55045705
85double-strand break repair via homologous recombination (GO:0000724)2.54776903
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51983298
87fusion of sperm to egg plasma membrane (GO:0007342)2.50272072
88positive regulation of male gonad development (GO:2000020)2.49909672
89recombinational repair (GO:0000725)2.49824080
90intracellular protein transmembrane import (GO:0044743)2.49294982
91cellular response to electrical stimulus (GO:0071257)2.48109839
92transcription from RNA polymerase I promoter (GO:0006360)2.48032996
93protein complex biogenesis (GO:0070271)2.47693143
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47657125
95sperm-egg recognition (GO:0035036)2.47051465
96cellular response to interleukin-6 (GO:0071354)2.44336936
97postreplication repair (GO:0006301)2.43568857
98exploration behavior (GO:0035640)2.43552873
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42980549
100positive regulation of protein homodimerization activity (GO:0090073)2.42153345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.52101203
2VDR_22108803_ChIP-Seq_LS180_Human3.78585701
3IGF1R_20145208_ChIP-Seq_DFB_Human3.49424586
4ZNF274_21170338_ChIP-Seq_K562_Hela3.33357883
5GBX2_23144817_ChIP-Seq_PC3_Human2.92597950
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74647561
7FUS_26573619_Chip-Seq_HEK293_Human2.60689677
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57036132
9EWS_26573619_Chip-Seq_HEK293_Human2.32328127
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.29005201
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.26252293
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23294423
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16489087
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14505437
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07567392
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87107276
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84443807
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.82782414
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81449534
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80861481
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78028369
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77572292
23P300_19829295_ChIP-Seq_ESCs_Human1.75714760
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73870744
25TAF15_26573619_Chip-Seq_HEK293_Human1.67991012
26ER_23166858_ChIP-Seq_MCF-7_Human1.61981454
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.61607949
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59291376
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.57189943
30BCAT_22108803_ChIP-Seq_LS180_Human1.54343903
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52026861
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52026861
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51527828
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50337717
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.50176275
36RNF2_27304074_Chip-Seq_NSC_Mouse1.47643424
37TP53_22573176_ChIP-Seq_HFKS_Human1.46803985
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45850011
39CBP_20019798_ChIP-Seq_JUKART_Human1.45850011
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44327239
41HTT_18923047_ChIP-ChIP_STHdh_Human1.43066275
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42715394
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40148488
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39605017
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38725368
46SMAD4_21799915_ChIP-Seq_A2780_Human1.38621928
47VDR_23849224_ChIP-Seq_CD4+_Human1.36399766
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35972499
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.34671814
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34539855
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33734938
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31121221
53GATA1_22025678_ChIP-Seq_K562_Human1.31020835
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30481932
55P53_22387025_ChIP-Seq_ESCs_Mouse1.28761099
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.28181557
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25689465
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25217729
59STAT3_23295773_ChIP-Seq_U87_Human1.24519513
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23861578
61AR_21572438_ChIP-Seq_LNCaP_Human1.23780483
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23125964
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21340795
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.21260558
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.20869136
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19071876
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.18225529
68NANOG_19829295_ChIP-Seq_ESCs_Human1.17950867
69SOX2_19829295_ChIP-Seq_ESCs_Human1.17950867
70AR_25329375_ChIP-Seq_VCAP_Human1.17189123
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14790437
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14460726
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14316949
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.13995458
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13630901
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.13344496
77TCF4_23295773_ChIP-Seq_U87_Human1.12444933
78KDM2B_26808549_Chip-Seq_REH_Human1.11488803
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.10131935
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.09630960
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09342577
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07333104
83TP53_16413492_ChIP-PET_HCT116_Human1.06702383
84RUNX2_22187159_ChIP-Seq_PCA_Human1.06567040
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06484003
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.06092762
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05853370
88SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05473171
89HOXB7_26014856_ChIP-Seq_BT474_Human1.05190917
90RXR_22108803_ChIP-Seq_LS180_Human1.05080219
91MYC_18940864_ChIP-ChIP_HL60_Human1.04789491
92P300_18555785_Chip-Seq_ESCs_Mouse1.04370366
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.03255441
94ELK1_19687146_ChIP-ChIP_HELA_Human1.02783027
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.02469684
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01874389
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01600548
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.00463223
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99946144
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99826505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.56293136
2MP0008877_abnormal_DNA_methylation4.35540728
3MP0002736_abnormal_nociception_after3.71014959
4MP0001968_abnormal_touch/_nociception3.42191394
5MP0005423_abnormal_somatic_nervous3.32270055
6MP0008057_abnormal_DNA_replication3.06178283
7MP0000372_irregular_coat_pigmentation2.79634855
8MP0005187_abnormal_penis_morphology2.77948897
9MP0002138_abnormal_hepatobiliary_system2.55615683
10MP0005646_abnormal_pituitary_gland2.55447227
11MP0000569_abnormal_digit_pigmentation2.50262989
12MP0003123_paternal_imprinting2.27442487
13MP0004859_abnormal_synaptic_plasticity2.18257619
14MP0005386_behavior/neurological_phenoty2.04876760
15MP0004924_abnormal_behavior2.04876760
16MP0003137_abnormal_impulse_conducting1.99295701
17MP0002735_abnormal_chemical_nociception1.97529186
18MP0003195_calcinosis1.92212791
19MP0005075_abnormal_melanosome_morpholog1.86645444
20MP0000647_abnormal_sebaceous_gland1.82278016
21MP0003880_abnormal_central_pattern1.77492242
22MP0001919_abnormal_reproductive_system1.76598162
23MP0000015_abnormal_ear_pigmentation1.75815496
24MP0002095_abnormal_skin_pigmentation1.60383804
25MP0000537_abnormal_urethra_morphology1.53782687
26MP0001188_hyperpigmentation1.53148250
27MP0001986_abnormal_taste_sensitivity1.49996795
28MP0000631_abnormal_neuroendocrine_gland1.47747339
29MP0003221_abnormal_cardiomyocyte_apopto1.47507556
30MP0003786_premature_aging1.45438805
31MP0002272_abnormal_nervous_system1.44828611
32MP0003315_abnormal_perineum_morphology1.42642999
33MP0002933_joint_inflammation1.41587970
34MP0005389_reproductive_system_phenotype1.34760481
35MP0009046_muscle_twitch1.31918526
36MP0005551_abnormal_eye_electrophysiolog1.30733818
37MP0000639_abnormal_adrenal_gland1.28718730
38MP0003787_abnormal_imprinting1.27787340
39MP0009785_altered_susceptibility_to1.27578211
40MP0002067_abnormal_sensory_capabilities1.26516545
41MP0005387_immune_system_phenotype1.25354636
42MP0001790_abnormal_immune_system1.25354636
43MP0002733_abnormal_thermal_nociception1.24374006
44MP0004133_heterotaxia1.24093131
45MP0004043_abnormal_pH_regulation1.23214520
46MP0004885_abnormal_endolymph1.22856435
47MP0008995_early_reproductive_senescence1.21505149
48MP0006072_abnormal_retinal_apoptosis1.18598465
49MP0009745_abnormal_behavioral_response1.18347087
50MP0001440_abnormal_grooming_behavior1.17338590
51MP0005410_abnormal_fertilization1.17040465
52MP0003635_abnormal_synaptic_transmissio1.15315473
53MP0001486_abnormal_startle_reflex1.11468748
54MP0002102_abnormal_ear_morphology1.10090690
55MP0010030_abnormal_orbit_morphology1.08387174
56MP0008875_abnormal_xenobiotic_pharmacok1.07841217
57MP0001501_abnormal_sleep_pattern1.07141538
58MP0005671_abnormal_response_to1.05086809
59MP0008569_lethality_at_weaning1.04247924
60MP0001970_abnormal_pain_threshold1.02182092
61MP0002332_abnormal_exercise_endurance1.01674627
62MP0005253_abnormal_eye_physiology1.01053006
63MP0001764_abnormal_homeostasis1.00458293
64MP0002063_abnormal_learning/memory/cond1.00143639
65MP0003121_genomic_imprinting0.98771504
66MP0008058_abnormal_DNA_repair0.98678986
67MP0002734_abnormal_mechanical_nocicepti0.96903302
68MP0008872_abnormal_physiological_respon0.94015463
69MP0002938_white_spotting0.93156595
70MP0002572_abnormal_emotion/affect_behav0.92313641
71MP0005266_abnormal_metabolism0.91415454
72MP0002557_abnormal_social/conspecific_i0.90784955
73MP0003828_pulmonary_edema0.84610421
74MP0003567_abnormal_fetal_cardiomyocyte0.83980491
75MP0000778_abnormal_nervous_system0.82711899
76MP0001905_abnormal_dopamine_level0.82422027
77MP0006035_abnormal_mitochondrial_morpho0.80224098
78MP0003186_abnormal_redox_activity0.79397738
79MP0002970_abnormal_white_adipose0.78317337
80MP0006276_abnormal_autonomic_nervous0.77440237
81MP0004085_abnormal_heartbeat0.77027340
82MP0000230_abnormal_systemic_arterial0.76715932
83MP0003045_fibrosis0.76218306
84MP0008873_increased_physiological_sensi0.74475047
85MP0003172_abnormal_lysosome_physiology0.74000784
86MP0002006_tumorigenesis0.73765558
87MP0005636_abnormal_mineral_homeostasis0.72928102
88MP0001119_abnormal_female_reproductive0.72391906
89MP0001929_abnormal_gametogenesis0.72357192
90MP0003698_abnormal_male_reproductive0.71530310
91MP0002210_abnormal_sex_determination0.70443686
92MP0000653_abnormal_sex_gland0.69794924
93MP0003943_abnormal_hepatobiliary_system0.69247435
94MP0000427_abnormal_hair_cycle0.67314271
95MP0004215_abnormal_myocardial_fiber0.66187885
96MP0003122_maternal_imprinting0.64873830
97MP0002822_catalepsy0.64385166
98MP0005174_abnormal_tail_pigmentation0.62219596
99MP0005448_abnormal_energy_balance0.61643812
100MP0002127_abnormal_cardiovascular_syste0.61167951

Predicted human phenotypes

RankGene SetZ-score
1Clumsiness (HP:0002312)4.80021867
2Hyperglycinemia (HP:0002154)4.56557698
3Dry hair (HP:0011359)4.40256456
4True hermaphroditism (HP:0010459)4.02308383
5Fair hair (HP:0002286)3.94832980
6Methylmalonic acidemia (HP:0002912)3.91241868
73-Methylglutaconic aciduria (HP:0003535)3.79860653
8Broad-based gait (HP:0002136)3.79505339
9Pancreatic cysts (HP:0001737)3.63512597
10Azoospermia (HP:0000027)3.34816130
11Progressive inability to walk (HP:0002505)3.27195865
12Neoplasm of the adrenal cortex (HP:0100641)3.25700962
13Cerebellar dysplasia (HP:0007033)3.15960516
14Absent speech (HP:0001344)3.15864169
15Type II lissencephaly (HP:0007260)3.04336284
16Acute necrotizing encephalopathy (HP:0006965)3.03391525
17Pancreatic fibrosis (HP:0100732)2.93588845
18Nephronophthisis (HP:0000090)2.91614620
19Sensorimotor neuropathy (HP:0007141)2.81381344
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.78441572
21Diaphragmatic weakness (HP:0009113)2.70813783
22Generalized hypopigmentation of hair (HP:0011358)2.70004728
23Impaired proprioception (HP:0010831)2.69997339
24Acute encephalopathy (HP:0006846)2.66689234
25Gonadal dysgenesis (HP:0000133)2.58407180
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55921494
27Abnormality of alanine metabolism (HP:0010916)2.55921494
28Hyperalaninemia (HP:0003348)2.55921494
29Methylmalonic aciduria (HP:0012120)2.52602185
30Focal motor seizures (HP:0011153)2.50055340
31Progressive macrocephaly (HP:0004481)2.49761078
32Abnormality of the renal medulla (HP:0100957)2.48627572
33Stridor (HP:0010307)2.47353310
34Mitochondrial inheritance (HP:0001427)2.46486643
35Abnormality of midbrain morphology (HP:0002418)2.44897315
36Molar tooth sign on MRI (HP:0002419)2.44897315
37Abnormal spermatogenesis (HP:0008669)2.44082756
38Abnormality of serum amino acid levels (HP:0003112)2.40098698
39Abnormal mitochondria in muscle tissue (HP:0008316)2.39711703
40Female pseudohermaphroditism (HP:0010458)2.35698545
41Abnormality of serine family amino acid metabolism (HP:0010894)2.33237031
42Abnormality of glycine metabolism (HP:0010895)2.33237031
43Male pseudohermaphroditism (HP:0000037)2.28672839
44Chronic hepatic failure (HP:0100626)2.28236511
45Bile duct proliferation (HP:0001408)2.23382035
46Abnormal biliary tract physiology (HP:0012439)2.23382035
47Abnormality of the ileum (HP:0001549)2.21569718
48Increased CSF lactate (HP:0002490)2.21168095
49Chronic mucocutaneous candidiasis (HP:0002728)2.16112575
50Recurrent cutaneous fungal infections (HP:0011370)2.16112575
51Brushfield spots (HP:0001088)2.15954118
52Aplasia/hypoplasia of the uterus (HP:0008684)2.14485580
53Inability to walk (HP:0002540)2.14152427
54Abnormality of the vitamin B12 metabolism (HP:0004341)2.13669723
55Hyperventilation (HP:0002883)2.13110652
56High anterior hairline (HP:0009890)2.11807953
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.11469549
58Meckel diverticulum (HP:0002245)2.09796286
59Abnormality of the axillary hair (HP:0100134)2.09536584
60Abnormality of secondary sexual hair (HP:0009888)2.09536584
61Poor eye contact (HP:0000817)2.08229447
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06023812
63Global brain atrophy (HP:0002283)2.05644115
64Fibular aplasia (HP:0002990)2.04022375
65Occipital encephalocele (HP:0002085)1.99397863
66Increased hepatocellular lipid droplets (HP:0006565)1.98910973
67Anterior segment dysgenesis (HP:0007700)1.98395717
68Testicular neoplasm (HP:0010788)1.97141725
69Stomach cancer (HP:0012126)1.95717258
70Abnormality of vitamin B metabolism (HP:0004340)1.95340650
71Periodontitis (HP:0000704)1.94695769
72Birth length less than 3rd percentile (HP:0003561)1.94253775
73Mesangial abnormality (HP:0001966)1.90835955
74Congenital, generalized hypertrichosis (HP:0004540)1.88124386
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87765960
76Degeneration of the lateral corticospinal tracts (HP:0002314)1.87765960
77Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87125025
78Abnormality of the renal cortex (HP:0011035)1.86476239
79Optic neuritis (HP:0100653)1.85740482
80Retrobulbar optic neuritis (HP:0100654)1.85740482
81Hypoplasia of the uterus (HP:0000013)1.85677554
82Severe visual impairment (HP:0001141)1.85318354
83Cerebral edema (HP:0002181)1.85292640
84Type I transferrin isoform profile (HP:0003642)1.85079028
85Growth hormone deficiency (HP:0000824)1.83288132
86Abnormality of urine glucose concentration (HP:0011016)1.80759356
87Glycosuria (HP:0003076)1.80759356
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.80615621
89Mutism (HP:0002300)1.80519597
90Congenital stationary night blindness (HP:0007642)1.78692588
91Cheilitis (HP:0100825)1.78661846
92Cystic liver disease (HP:0006706)1.77986518
93Retinal dysplasia (HP:0007973)1.77302055
94Neoplasm of the adrenal gland (HP:0100631)1.76764758
95Menstrual irregularities (HP:0000858)1.76607584
96Abolished electroretinogram (ERG) (HP:0000550)1.74712178
97Primary adrenal insufficiency (HP:0008207)1.73931788
98Increased serum lactate (HP:0002151)1.72804202
99Hepatocellular necrosis (HP:0001404)1.72348016
100Anhidrosis (HP:0000970)1.71524264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.61552318
2ZAK2.95310869
3CASK2.93274986
4AKT32.80660157
5NEK12.58083569
6FER2.55119235
7EPHA42.55104260
8TLK12.48617904
9EIF2AK32.42514351
10MAP3K42.42325838
11DYRK32.38195059
12MARK12.35413598
13WNK42.21733604
14NEK92.19099455
15PNCK2.10042861
16MST42.05374395
17WNK32.03212951
18PBK1.95650640
19MAP2K71.95443215
20OXSR11.80796435
21MAPKAPK31.79617471
22MAPK131.79389478
23CDK191.61692123
24MKNK21.58205255
25TYK21.54015659
26CAMK1G1.53063511
27PRKD31.51601461
28KIT1.50134034
29STK391.49271222
30TXK1.48712124
31TYRO31.48069726
32ADRBK21.45927050
33ACVR1B1.42580880
34FRK1.37808131
35PLK41.36908679
36CAMK1D1.21795421
37CDC71.13612696
38ATR1.07134745
39EIF2AK21.03785865
40SRPK11.02983324
41GRK11.02354487
42TSSK60.96981444
43PRKCE0.87075800
44PHKG10.87039453
45PHKG20.87039453
46PRKCG0.84088592
47TAOK30.83429317
48SIK20.78564275
49TRIM280.75449108
50JAK30.75218501
51TNK20.71862285
52BMPR1B0.70239950
53ERBB30.69865616
54MET0.69798346
55NUAK10.69362280
56NTRK30.68869704
57CSNK1A1L0.66633803
58WEE10.64044538
59CSNK1G10.61702426
60CAMKK20.61466677
61DYRK20.61359633
62SGK20.60818398
63PLK10.58138059
64BMPR20.57100888
65NEK20.55607421
66PIM10.54122812
67CAMK2D0.52201036
68MAP2K40.51648996
69VRK10.49862043
70DAPK30.49239595
71CAMK2G0.47732012
72STK160.47416700
73CSNK1G30.46749824
74RPS6KB10.46495364
75INSRR0.45473627
76IKBKE0.45258979
77WNK10.45081895
78TAOK20.43637249
79CLK10.42905005
80MKNK10.42582264
81CSNK1G20.41786332
82MINK10.40874499
83VRK20.40595998
84SGK2230.39849118
85SGK4940.39849118
86PRKCQ0.38545717
87GRK70.37808036
88PASK0.37461809
89PKN10.36305334
90ATM0.36281220
91IKBKB0.35978660
92PRKCZ0.35066498
93CAMK2B0.35036570
94RPS6KA50.34986497
95ABL10.34936530
96PRKACA0.32005348
97CCNB10.31409763
98BCKDK0.30701188
99BRAF0.29964991
100PLK30.28298171

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.95528997
2Nitrogen metabolism_Homo sapiens_hsa009103.30946610
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.07002335
4Proteasome_Homo sapiens_hsa030502.77009547
5Propanoate metabolism_Homo sapiens_hsa006402.68990055
6Fanconi anemia pathway_Homo sapiens_hsa034602.32073069
7Linoleic acid metabolism_Homo sapiens_hsa005912.22939597
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.10716205
9Basal transcription factors_Homo sapiens_hsa030222.08762845
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04976197
11Ether lipid metabolism_Homo sapiens_hsa005651.99103291
12Regulation of autophagy_Homo sapiens_hsa041401.93292654
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92737169
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79265470
15Homologous recombination_Homo sapiens_hsa034401.77634813
16Oxidative phosphorylation_Homo sapiens_hsa001901.77495690
17RNA degradation_Homo sapiens_hsa030181.70039366
18Selenocompound metabolism_Homo sapiens_hsa004501.64787853
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63720105
20Primary immunodeficiency_Homo sapiens_hsa053401.62106189
21Mismatch repair_Homo sapiens_hsa034301.57962165
22RNA polymerase_Homo sapiens_hsa030201.57818725
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57282576
24Parkinsons disease_Homo sapiens_hsa050121.45334592
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44541424
26beta-Alanine metabolism_Homo sapiens_hsa004101.44344999
27Peroxisome_Homo sapiens_hsa041461.42360927
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40619264
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39733258
30Nucleotide excision repair_Homo sapiens_hsa034201.33183904
31Phototransduction_Homo sapiens_hsa047441.32828805
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29319714
33Olfactory transduction_Homo sapiens_hsa047401.19142047
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16914608
35Protein export_Homo sapiens_hsa030601.16686716
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.16559898
37Glutamatergic synapse_Homo sapiens_hsa047241.15922407
38Morphine addiction_Homo sapiens_hsa050321.09098041
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08582283
40Circadian rhythm_Homo sapiens_hsa047101.05333163
41Huntingtons disease_Homo sapiens_hsa050161.04937038
42Taste transduction_Homo sapiens_hsa047421.03933007
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01085394
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00076433
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98792498
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98041855
47Nicotine addiction_Homo sapiens_hsa050330.97959553
48Circadian entrainment_Homo sapiens_hsa047130.92207496
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92121020
50Fat digestion and absorption_Homo sapiens_hsa049750.88729104
51Base excision repair_Homo sapiens_hsa034100.88442274
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86918014
53Arachidonic acid metabolism_Homo sapiens_hsa005900.85259453
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84028726
55Serotonergic synapse_Homo sapiens_hsa047260.81359821
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80733623
57Fatty acid biosynthesis_Homo sapiens_hsa000610.80143242
58Pyruvate metabolism_Homo sapiens_hsa006200.78585252
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.77798116
60Vitamin digestion and absorption_Homo sapiens_hsa049770.76562984
61Long-term depression_Homo sapiens_hsa047300.72726775
62Salivary secretion_Homo sapiens_hsa049700.72367042
63Pyrimidine metabolism_Homo sapiens_hsa002400.71456472
64Dopaminergic synapse_Homo sapiens_hsa047280.70928776
65DNA replication_Homo sapiens_hsa030300.70462163
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.68586376
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67195531
68Steroid biosynthesis_Homo sapiens_hsa001000.65077417
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64553984
70Fatty acid degradation_Homo sapiens_hsa000710.62718366
71Measles_Homo sapiens_hsa051620.62082294
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.61815764
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61362681
74Alzheimers disease_Homo sapiens_hsa050100.60337906
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60224072
76Purine metabolism_Homo sapiens_hsa002300.59521748
77Synaptic vesicle cycle_Homo sapiens_hsa047210.53987773
78Calcium signaling pathway_Homo sapiens_hsa040200.53539167
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.53076659
80RNA transport_Homo sapiens_hsa030130.52956396
81Tryptophan metabolism_Homo sapiens_hsa003800.51589015
82Chemical carcinogenesis_Homo sapiens_hsa052040.51187673
83Non-homologous end-joining_Homo sapiens_hsa034500.49684008
84Fatty acid metabolism_Homo sapiens_hsa012120.48895434
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48440473
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.47378374
87Amphetamine addiction_Homo sapiens_hsa050310.46749152
88One carbon pool by folate_Homo sapiens_hsa006700.45925580
89GABAergic synapse_Homo sapiens_hsa047270.45639998
90Metabolic pathways_Homo sapiens_hsa011000.41602332
91Butanoate metabolism_Homo sapiens_hsa006500.41143727
92Sulfur metabolism_Homo sapiens_hsa009200.38509245
93Histidine metabolism_Homo sapiens_hsa003400.37963323
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37477387
95Epstein-Barr virus infection_Homo sapiens_hsa051690.37032906
96Fatty acid elongation_Homo sapiens_hsa000620.36142478
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.35765549
98Lysine degradation_Homo sapiens_hsa003100.34580691
99Cocaine addiction_Homo sapiens_hsa050300.34010761
100p53 signaling pathway_Homo sapiens_hsa041150.33384421

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