VDAC2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)9.76220293
2cellular response to interferon-beta (GO:0035458)9.48778172
3diol metabolic process (GO:0034311)8.92340929
4DNA deamination (GO:0045006)8.09925351
5centriole replication (GO:0007099)8.06115358
6sphingoid metabolic process (GO:0046519)7.78962989
7cytidine metabolic process (GO:0046087)7.75530886
8cytidine catabolic process (GO:0006216)7.75530886
9cytidine deamination (GO:0009972)7.75530886
10positive regulation of defense response to virus by host (GO:0002230)7.62553787
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.27192861
12pyrimidine ribonucleoside catabolic process (GO:0046133)6.89241076
13protein localization to microtubule (GO:0035372)6.50557099
14response to histamine (GO:0034776)6.42906108
15response to interferon-beta (GO:0035456)6.41806520
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.64941637
17galactose metabolic process (GO:0006012)5.50613811
18valine metabolic process (GO:0006573)5.44461152
19cellular response to interleukin-15 (GO:0071350)5.42082289
20centriole assembly (GO:0098534)5.41879737
21sulfate transmembrane transport (GO:1902358)5.35105016
22interleukin-6-mediated signaling pathway (GO:0070102)5.33130802
23cellular defense response (GO:0006968)5.25769883
24response to interleukin-15 (GO:0070672)4.91713115
25behavioral response to nicotine (GO:0035095)4.73206310
26sulfate transport (GO:0008272)4.71591215
27regulation of defense response to virus by host (GO:0050691)4.62934987
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.49118030
29cardiovascular system development (GO:0072358)4.46145902
30response to xenobiotic stimulus (GO:0009410)4.42823563
31growth hormone receptor signaling pathway (GO:0060396)4.39792456
32regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.33350164
33radial glial cell differentiation (GO:0060019)4.20174914
34protein-chromophore linkage (GO:0018298)4.17168351
35regulation of pigment cell differentiation (GO:0050932)4.06230113
36negative regulation of transcription regulatory region DNA binding (GO:2000678)4.05030170
37regulation of interleukin-12 biosynthetic process (GO:0045075)4.00991302
38cellular response to ammonium ion (GO:0071242)3.97327537
39pyrimidine nucleoside catabolic process (GO:0046135)3.88783098
40positive regulation of calcium-mediated signaling (GO:0050850)3.88141479
41cellular response to growth hormone stimulus (GO:0071378)3.86130397
42replication fork processing (GO:0031297)3.75461572
43pentose metabolic process (GO:0019321)3.72693039
44DNA methylation involved in gamete generation (GO:0043046)3.70480679
45sexual reproduction (GO:0019953)3.68163116
46positive regulation of developmental pigmentation (GO:0048087)3.59222078
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.58742281
48intestinal epithelial cell development (GO:0060576)3.57766164
49positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.56500544
50protein localization to microtubule cytoskeleton (GO:0072698)3.56415506
51hepatocyte apoptotic process (GO:0097284)3.56236152
52photoreceptor cell differentiation (GO:0046530)3.55838519
53eye photoreceptor cell differentiation (GO:0001754)3.55838519
54activated T cell proliferation (GO:0050798)3.55722958
55regulation of chromatin silencing (GO:0031935)3.40274169
56negative regulation of macroautophagy (GO:0016242)3.37006924
57positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.36028119
58negative regulation of cell killing (GO:0031342)3.34904772
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34904772
60regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.33577109
61positive regulation of cell killing (GO:0031343)3.26440600
62positive regulation of natural killer cell mediated immunity (GO:0002717)3.25221693
63histone H3-K4 trimethylation (GO:0080182)3.24567678
64positive regulation of gamma-delta T cell activation (GO:0046645)3.24557579
65protein localization to cytoskeleton (GO:0044380)3.24476243
66necroptotic process (GO:0070266)3.21544772
67lipopolysaccharide metabolic process (GO:0008653)3.17208378
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.15263421
69negative regulation of glycoprotein biosynthetic process (GO:0010561)3.10648247
70serotonin receptor signaling pathway (GO:0007210)3.10557858
71regulation of T cell mediated cytotoxicity (GO:0001914)3.09220931
72regulation of leukocyte mediated cytotoxicity (GO:0001910)3.09175430
73regulation of meiosis I (GO:0060631)3.08609571
74positive regulation of fatty acid oxidation (GO:0046321)3.05147477
75regulation of gamma-delta T cell differentiation (GO:0045586)3.03886534
76positive T cell selection (GO:0043368)3.03085198
77cellular response to gamma radiation (GO:0071480)3.01658158
78piRNA metabolic process (GO:0034587)2.94515443
79positive regulation of cell cycle G2/M phase transition (GO:1902751)2.93831651
80positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.93831651
81regulation of sequestering of triglyceride (GO:0010889)2.92795553
82regulation of natural killer cell mediated immunity (GO:0002715)2.89617761
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89617761
84regulation of calcium-mediated signaling (GO:0050848)2.88904463
85regulation of cell killing (GO:0031341)2.85040998
86negative regulation of translational initiation (GO:0045947)2.83088364
87positive regulation of B cell differentiation (GO:0045579)2.81686299
88regulation of platelet aggregation (GO:0090330)2.78592565
89negative regulation of interleukin-12 production (GO:0032695)2.78418734
90regulation of glycolytic process (GO:0006110)2.78175546
91astrocyte differentiation (GO:0048708)2.75367201
92regulation of transforming growth factor beta2 production (GO:0032909)2.73474884
93regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.73147411
94regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.73147411
95attachment of spindle microtubules to kinetochore (GO:0008608)2.73048751
96lipopolysaccharide biosynthetic process (GO:0009103)2.72061203
97peptidyl-histidine modification (GO:0018202)2.69093314
98regulation of hippo signaling (GO:0035330)2.67545242
99positive regulation of histone H3-K4 methylation (GO:0051571)2.66731487
100regulation of protein glycosylation (GO:0060049)2.66652056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.63521929
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.60909099
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.26488871
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.34686965
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20269738
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.77380581
7AR_21572438_ChIP-Seq_LNCaP_Human3.43736998
8VDR_22108803_ChIP-Seq_LS180_Human2.98252257
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67504239
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.66100471
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55965252
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48045422
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40838145
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.23720308
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.14707334
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.11053506
17GBX2_23144817_ChIP-Seq_PC3_Human2.04305037
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91959927
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88122217
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87314521
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84539040
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72033243
23RUNX_20019798_ChIP-Seq_JUKART_Human1.67893533
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66005585
25GATA3_26560356_Chip-Seq_TH2_Human1.65532009
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53997142
27AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50934492
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.48540788
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46487781
30HTT_18923047_ChIP-ChIP_STHdh_Human1.44992134
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41314205
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41280522
33OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34734702
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34731364
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34731364
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.34177232
37CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33788923
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33696702
39IGF1R_20145208_ChIP-Seq_DFB_Human1.27297862
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26229187
41CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21209891
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20484274
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.18371806
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15134887
45SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14614437
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14448484
47BCAT_22108803_ChIP-Seq_LS180_Human1.14378551
48MYB_26560356_Chip-Seq_TH2_Human1.14181317
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.12347006
50GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.12238755
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11265304
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10631049
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.10199683
54P300_19829295_ChIP-Seq_ESCs_Human1.10101591
55FOXH1_21741376_ChIP-Seq_ESCs_Human1.08548035
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.08545232
57CIITA_25753668_ChIP-Seq_RAJI_Human1.08303373
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.05716594
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05133834
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.05133834
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.04603356
62TAF15_26573619_Chip-Seq_HEK293_Human1.03967744
63HOXB7_26014856_ChIP-Seq_BT474_Human1.03791742
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03371141
65TP53_16413492_ChIP-PET_HCT116_Human1.01809377
66EWS_26573619_Chip-Seq_HEK293_Human1.01319491
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00735557
68ZNF274_21170338_ChIP-Seq_K562_Hela1.00098233
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99386563
70FLI1_21867929_ChIP-Seq_TH2_Mouse0.98594608
71STAT3_23295773_ChIP-Seq_U87_Human0.98296518
72SMAD4_21741376_ChIP-Seq_EPCs_Human0.95221682
73MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95058159
74TP53_22573176_ChIP-Seq_HFKS_Human0.93295919
75GATA3_21878914_ChIP-Seq_MCF-7_Human0.93011248
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91218146
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91216715
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89786217
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89635924
80GATA3_26560356_Chip-Seq_TH1_Human0.88334421
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87851411
82CDX2_22108803_ChIP-Seq_LS180_Human0.87813582
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86896087
84GATA3_27048872_Chip-Seq_THYMUS_Human0.86550021
85CBP_20019798_ChIP-Seq_JUKART_Human0.86542735
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86542735
87FOXP3_21729870_ChIP-Seq_TREG_Human0.85469511
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.84220525
89MYC_19829295_ChIP-Seq_ESCs_Human0.83077396
90SOX2_19829295_ChIP-Seq_ESCs_Human0.82658786
91NANOG_19829295_ChIP-Seq_ESCs_Human0.82658786
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82208465
93OCT4_20526341_ChIP-Seq_ESCs_Human0.81596448
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81174856
95ER_23166858_ChIP-Seq_MCF-7_Human0.81163208
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80790974
97GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.80448695
98TCF4_22108803_ChIP-Seq_LS180_Human0.80235487
99VDR_24787735_ChIP-Seq_THP-1_Human0.79922621
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79851771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis8.23511842
2MP0003045_fibrosis4.64860880
3MP0005171_absent_coat_pigmentation4.02634222
4MP0003878_abnormal_ear_physiology3.42791052
5MP0005377_hearing/vestibular/ear_phenot3.42791052
6MP0000569_abnormal_digit_pigmentation3.41273508
7MP0008057_abnormal_DNA_replication3.23156676
8MP0003136_yellow_coat_color3.07827007
9MP0001853_heart_inflammation2.97990231
10MP0004381_abnormal_hair_follicle2.64986449
11MP0003763_abnormal_thymus_physiology2.62525351
12MP0010352_gastrointestinal_tract_polyps2.62056915
13MP0002653_abnormal_ependyma_morphology2.57978092
14MP0003300_gastrointestinal_ulcer2.56735648
15MP0002138_abnormal_hepatobiliary_system2.56148821
16MP0004084_abnormal_cardiac_muscle2.41931977
17MP0003183_abnormal_peptide_metabolism2.41600823
18MP0003646_muscle_fatigue2.36891014
19MP0004036_abnormal_muscle_relaxation2.31359327
20MP0001835_abnormal_antigen_presentation2.20766109
21MP0002736_abnormal_nociception_after2.15293918
22MP0005671_abnormal_response_to2.10713269
23MP0005075_abnormal_melanosome_morpholog2.07812153
24MP0008775_abnormal_heart_ventricle2.05570628
25MP0005670_abnormal_white_adipose2.04739666
26MP0000685_abnormal_immune_system1.94338195
27MP0001968_abnormal_touch/_nociception1.86877073
28MP0003866_abnormal_defecation1.83534889
29MP0002168_other_aberrant_phenotype1.64397655
30MP0004142_abnormal_muscle_tone1.50709643
31MP0005167_abnormal_blood-brain_barrier1.43539821
32MP0002938_white_spotting1.42077516
33MP0003890_abnormal_embryonic-extraembry1.40451091
34MP0000372_irregular_coat_pigmentation1.37951269
35MP0002254_reproductive_system_inflammat1.37821542
36MP0005085_abnormal_gallbladder_physiolo1.32539378
37MP0001800_abnormal_humoral_immune1.27917428
38MP0003959_abnormal_lean_body1.25562231
39MP0000703_abnormal_thymus_morphology1.22898626
40MP0004215_abnormal_myocardial_fiber1.17291655
41MP0006082_CNS_inflammation1.12389384
42MP0002723_abnormal_immune_serum1.11035524
43MP0001790_abnormal_immune_system1.10452910
44MP0005387_immune_system_phenotype1.10452910
45MP0002163_abnormal_gland_morphology1.04699304
46MP0003879_abnormal_hair_cell1.01759967
47MP0005174_abnormal_tail_pigmentation1.01196887
48MP0005330_cardiomyopathy0.99793690
49MP0005448_abnormal_energy_balance0.98763024
50MP0000689_abnormal_spleen_morphology0.98737582
51MP0006035_abnormal_mitochondrial_morpho0.98684899
52MP0003566_abnormal_cell_adhesion0.98269618
53MP0002272_abnormal_nervous_system0.95766919
54MP0002452_abnormal_antigen_presenting0.95056770
55MP0005025_abnormal_response_to0.91289381
56MP0002420_abnormal_adaptive_immunity0.90526376
57MP0005266_abnormal_metabolism0.89355212
58MP0001819_abnormal_immune_cell0.86231393
59MP0002095_abnormal_skin_pigmentation0.85264896
60MP0005165_increased_susceptibility_to0.85161789
61MP0002722_abnormal_immune_system0.85133239
62MP0003252_abnormal_bile_duct0.84499050
63MP0005395_other_phenotype0.82134133
64MP0000716_abnormal_immune_system0.81847438
65MP0009333_abnormal_splenocyte_physiolog0.80376865
66MP0010155_abnormal_intestine_physiology0.79866112
67MP0005365_abnormal_bile_salt0.73837490
68MP0005000_abnormal_immune_tolerance0.73800837
69MP0005535_abnormal_body_temperature0.73584781
70MP0009764_decreased_sensitivity_to0.72665863
71MP0001764_abnormal_homeostasis0.71701960
72MP0004147_increased_porphyrin_level0.71264472
73MP0002751_abnormal_autonomic_nervous0.70831241
74MP0002419_abnormal_innate_immunity0.70068877
75MP0005408_hypopigmentation0.68504679
76MP0008469_abnormal_protein_level0.68039761
77MP0000358_abnormal_cell_content/0.66578484
78MP0003943_abnormal_hepatobiliary_system0.64519272
79MP0002075_abnormal_coat/hair_pigmentati0.63552754
80MP0009046_muscle_twitch0.62999515
81MP0002166_altered_tumor_susceptibility0.62378835
82MP0002398_abnormal_bone_marrow0.61589456
83MP0009763_increased_sensitivity_to0.61166267
84MP0005410_abnormal_fertilization0.60790691
85MP0001986_abnormal_taste_sensitivity0.60503702
86MP0005464_abnormal_platelet_physiology0.59673308
87MP0005319_abnormal_enzyme/_coenzyme0.59667748
88MP0008872_abnormal_physiological_respon0.58738743
89MP0001756_abnormal_urination0.58190670
90MP0002998_abnormal_bone_remodeling0.57543130
91MP0000749_muscle_degeneration0.56833923
92MP0004782_abnormal_surfactant_physiolog0.56611780
93MP0002429_abnormal_blood_cell0.56404689
94MP0000427_abnormal_hair_cycle0.56223466
95MP0001664_abnormal_digestion0.55947498
96MP0002405_respiratory_system_inflammati0.54853770
97MP0005376_homeostasis/metabolism_phenot0.53136201
98MP0005551_abnormal_eye_electrophysiolog0.51222646
99MP0006138_congestive_heart_failure0.50852412
100MP0002148_abnormal_hypersensitivity_rea0.50300399

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.46853084
2Recurrent cutaneous fungal infections (HP:0011370)6.33509593
3Chronic mucocutaneous candidiasis (HP:0002728)6.33509593
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.48060978
5Agammaglobulinemia (HP:0004432)5.33117595
6Panhypogammaglobulinemia (HP:0003139)5.24905175
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.18336211
8Pigmentary retinal degeneration (HP:0001146)4.70454776
9Petechiae (HP:0000967)4.62219895
10T lymphocytopenia (HP:0005403)4.46279099
11Colitis (HP:0002583)4.42103871
12Recurrent fungal infections (HP:0002841)4.27415682
13Abnormality of T cells (HP:0002843)4.02022267
14Prolonged neonatal jaundice (HP:0006579)4.00999732
15Eczematoid dermatitis (HP:0000976)3.89988958
16Viral hepatitis (HP:0006562)3.84898224
17Amelogenesis imperfecta (HP:0000705)3.82339635
18Abnormality of T cell number (HP:0011839)3.82314738
19Lower limb hyperreflexia (HP:0002395)3.81402684
20IgG deficiency (HP:0004315)3.71582814
21Focal motor seizures (HP:0011153)3.70490246
22Central scotoma (HP:0000603)3.58968876
23J-shaped sella turcica (HP:0002680)3.56964925
24Recurrent bronchitis (HP:0002837)3.52329734
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.51001332
26Chronic diarrhea (HP:0002028)3.50293473
27Severe combined immunodeficiency (HP:0004430)3.48288549
28Poor head control (HP:0002421)3.25278890
29Thyroiditis (HP:0100646)3.21010937
30Increased IgE level (HP:0003212)3.21002845
31Purpura (HP:0000979)3.15531023
32Persistence of primary teeth (HP:0006335)3.14615115
33Systemic lupus erythematosus (HP:0002725)3.05062267
34Recurrent skin infections (HP:0001581)3.02622249
35Abnormality of eosinophils (HP:0001879)3.01434524
36Aplastic anemia (HP:0001915)3.00722742
37Encephalitis (HP:0002383)2.96358880
38Hemorrhage of the eye (HP:0011885)2.88561007
39Hypoplasia of the thymus (HP:0000778)2.88169186
40Carpal bone hypoplasia (HP:0001498)2.87919994
41Abnormality of macular pigmentation (HP:0008002)2.84922883
42Congenital ichthyosiform erythroderma (HP:0007431)2.82274258
43Broad ribs (HP:0000885)2.81654981
44Leukocytosis (HP:0001974)2.79739796
45Abnormality of T cell physiology (HP:0011840)2.77264865
46Congenital stationary night blindness (HP:0007642)2.76044823
47Tetraplegia (HP:0002445)2.73637104
48Micronodular cirrhosis (HP:0001413)2.71919393
49Severe visual impairment (HP:0001141)2.70392634
50Horizontal nystagmus (HP:0000666)2.67869534
51Erythroderma (HP:0001019)2.64330725
52Combined immunodeficiency (HP:0005387)2.64243927
53Inflammation of the large intestine (HP:0002037)2.63247180
54Basal ganglia calcification (HP:0002135)2.62526927
55Interstitial pulmonary disease (HP:0006530)2.54139220
56Stenosis of the external auditory canal (HP:0000402)2.50934536
57Hemiparesis (HP:0001269)2.50386034
58Vertebral arch anomaly (HP:0008438)2.44184025
59Abnormality of the periventricular white matter (HP:0002518)2.43795217
60Stomach cancer (HP:0012126)2.43470507
61Recurrent viral infections (HP:0004429)2.42953494
62Diastasis recti (HP:0001540)2.39850630
63Gastrointestinal inflammation (HP:0004386)2.35768565
64Stomatitis (HP:0010280)2.30752750
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26692820
66Scotoma (HP:0000575)2.26353089
67Hypoplasia of the fovea (HP:0007750)2.26083136
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.26083136
69Abnormality of small intestinal villus morphology (HP:0011472)2.23397423
70Villous atrophy (HP:0011473)2.23397423
71Pancreatic cysts (HP:0001737)2.23191154
72Vasculitis (HP:0002633)2.23124629
73Parakeratosis (HP:0001036)2.22644394
74Deformed sella turcica (HP:0002681)2.16982913
75Acanthocytosis (HP:0001927)2.11364873
76Amyotrophic lateral sclerosis (HP:0007354)2.05029386
77Spontaneous hematomas (HP:0007420)2.04286549
78Cutaneous melanoma (HP:0012056)2.04224691
79Arthropathy (HP:0003040)2.03442820
80Hepatitis (HP:0012115)2.00920563
81Eosinophilia (HP:0001880)2.00202584
82Aplasia/Hypoplasia of the macula (HP:0008059)1.98348240
83Pustule (HP:0200039)1.95227792
84Progressive hearing impairment (HP:0001730)1.93964963
85Morphological abnormality of the pyramidal tract (HP:0002062)1.93180405
86Hyperlipoproteinemia (HP:0010980)1.90799148
87Childhood onset (HP:0011463)1.90510032
88Abnormality of the corticospinal tract (HP:0002492)1.89608035
89Chronic hepatic failure (HP:0100626)1.88863871
90Hand muscle atrophy (HP:0009130)1.88801892
91Thyroid-stimulating hormone excess (HP:0002925)1.87911273
92Thoracic kyphosis (HP:0002942)1.84876086
93Bronchitis (HP:0012387)1.84547330
94Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81154486
95Disproportionate short-trunk short stature (HP:0003521)1.80726410
96Albinism (HP:0001022)1.80638857
97Abnormality of the pericardium (HP:0001697)1.78521563
98Lymphoma (HP:0002665)1.76656379
99Meningitis (HP:0001287)1.70787046
100Dialeptic seizures (HP:0011146)1.69994839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA37.35445006
2TXK5.68814758
3EPHB14.64713101
4LATS14.28785840
5NLK4.02385439
6FGFR43.76783404
7STK38L3.59713313
8IRAK43.25230104
9IRAK12.73773725
10MAP4K12.40846803
11MAP3K32.21695999
12LATS22.16398975
13FGFR32.06852276
14MAP2K32.04313100
15SGK21.85315898
16PRKD31.72210928
17ZAK1.58124299
18FER1.54965117
19SGK31.54325117
20DYRK31.40268598
21AKT31.40022552
22HIPK21.34403772
23SGK4941.30367504
24SGK2231.30367504
25STK381.26379880
26ADRBK21.25607327
27FRK1.25073804
28RPS6KA41.24806076
29DYRK21.13898139
30MAP3K11.08232727
31PTK2B1.07799121
32DAPK21.05801347
33NUAK11.02973784
34MAPK121.02589963
35MST40.96521177
36FES0.86688830
37RPS6KA50.85773891
38JAK10.81964673
39ALK0.81529862
40MAP2K20.72886831
41ACVR1B0.70401507
42RET0.69832242
43EIF2AK30.67700456
44ITK0.64008408
45IKBKB0.59991076
46HCK0.57435369
47MAP3K80.56146243
48CSK0.55660754
49CHUK0.55390417
50BMPR1B0.51566432
51AKT20.46042934
52STK30.44224057
53TAOK30.43104048
54ZAP700.42894378
55CAMK40.40548151
56MELK0.40485739
57PRKCE0.39545640
58TEC0.37270969
59ADRBK10.37087956
60GRK50.36568672
61PIK3CG0.36320581
62SYK0.33981786
63TIE10.33210800
64TLK10.32947362
65MAPKAPK20.31806380
66IKBKE0.28830808
67CDK50.28210082
68PRKAA20.27309929
69PRKD10.26858620
70PDPK10.26251853
71NME20.24592388
72TNK20.23955944
73BLK0.23640546
74ATR0.22245429
75GRK70.21417766
76TGFBR20.21068723
77JAK20.18950735
78PRKCQ0.18924012
79PLK30.17895022
80MAP3K130.16324565
81WNK40.14849695
82PRKCI0.14651077
83TGFBR10.11632043
84PINK10.09396361
85RPS6KA60.08380298
86DYRK1B0.07873414
87BRAF0.06838055
88CAMKK20.06026258
89LCK0.04170773
90LYN0.03995419
91RPS6KL10.03752605
92RPS6KC10.03752605
93BTK0.03679811
94CAMK2A0.03403481
95SRPK10.02912459
96MARK30.02397540
97VRK10.02268437
98SGK10.00703923
99DYRK1A0.00480699
100MAP3K20.00449552

Predicted pathways (KEGG)

RankGene SetZ-score
1Antigen processing and presentation_Homo sapiens_hsa046127.39316385
2Primary immunodeficiency_Homo sapiens_hsa053405.30114766
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.78484137
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.87035301
5Phototransduction_Homo sapiens_hsa047442.78758340
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.74248793
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67413138
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.44168621
9Collecting duct acid secretion_Homo sapiens_hsa049662.33454047
10Sphingolipid metabolism_Homo sapiens_hsa006001.94311980
11Galactose metabolism_Homo sapiens_hsa000521.89697336
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84765529
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69708006
14Basal transcription factors_Homo sapiens_hsa030221.64654502
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.49338218
16Measles_Homo sapiens_hsa051621.35738957
17Graft-versus-host disease_Homo sapiens_hsa053321.25674844
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.25592089
19Taste transduction_Homo sapiens_hsa047421.24323309
20GABAergic synapse_Homo sapiens_hsa047271.23789343
21Morphine addiction_Homo sapiens_hsa050321.23354387
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14132292
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13025446
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12053545
25Autoimmune thyroid disease_Homo sapiens_hsa053201.09620788
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07026458
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04805149
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.02284427
29HIF-1 signaling pathway_Homo sapiens_hsa040660.98969444
30Acute myeloid leukemia_Homo sapiens_hsa052210.92141495
31Nitrogen metabolism_Homo sapiens_hsa009100.87838068
32Viral myocarditis_Homo sapiens_hsa054160.87177055
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84029877
34Tuberculosis_Homo sapiens_hsa051520.83308082
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82976357
36Nicotine addiction_Homo sapiens_hsa050330.82353460
37Allograft rejection_Homo sapiens_hsa053300.81904437
38Adipocytokine signaling pathway_Homo sapiens_hsa049200.79311578
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79032249
40Glycerolipid metabolism_Homo sapiens_hsa005610.78239440
41Dorso-ventral axis formation_Homo sapiens_hsa043200.77977303
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.76806324
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.76742585
44T cell receptor signaling pathway_Homo sapiens_hsa046600.76222029
45Serotonergic synapse_Homo sapiens_hsa047260.75969159
46Linoleic acid metabolism_Homo sapiens_hsa005910.70869584
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69418230
48Pancreatic cancer_Homo sapiens_hsa052120.69239257
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68962949
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68891716
51Homologous recombination_Homo sapiens_hsa034400.68771380
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68658222
53Regulation of autophagy_Homo sapiens_hsa041400.67927613
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66130147
55Platelet activation_Homo sapiens_hsa046110.62783914
56RNA degradation_Homo sapiens_hsa030180.62350906
57Toxoplasmosis_Homo sapiens_hsa051450.58807127
58Rheumatoid arthritis_Homo sapiens_hsa053230.57873823
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.56353014
60One carbon pool by folate_Homo sapiens_hsa006700.55061293
61Vitamin digestion and absorption_Homo sapiens_hsa049770.54808280
62Vibrio cholerae infection_Homo sapiens_hsa051100.52479821
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51837843
64VEGF signaling pathway_Homo sapiens_hsa043700.51674563
65Olfactory transduction_Homo sapiens_hsa047400.48799967
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46602006
67Hematopoietic cell lineage_Homo sapiens_hsa046400.46092033
68Chemokine signaling pathway_Homo sapiens_hsa040620.45166313
69Type I diabetes mellitus_Homo sapiens_hsa049400.44232124
70Glutathione metabolism_Homo sapiens_hsa004800.43969912
71Calcium signaling pathway_Homo sapiens_hsa040200.43206932
72Cholinergic synapse_Homo sapiens_hsa047250.40685710
73Circadian rhythm_Homo sapiens_hsa047100.40381195
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40313481
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39465851
76Hepatitis C_Homo sapiens_hsa051600.38168143
77Renin secretion_Homo sapiens_hsa049240.38020343
78TNF signaling pathway_Homo sapiens_hsa046680.37892655
79cAMP signaling pathway_Homo sapiens_hsa040240.37186224
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36778051
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36561587
82Mismatch repair_Homo sapiens_hsa034300.36339038
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.36031789
84Glutamatergic synapse_Homo sapiens_hsa047240.35142445
85ABC transporters_Homo sapiens_hsa020100.35125080
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34320369
87Fatty acid biosynthesis_Homo sapiens_hsa000610.33488829
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33293513
89Arachidonic acid metabolism_Homo sapiens_hsa005900.33190218
90Insulin secretion_Homo sapiens_hsa049110.32705540
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31246693
92Viral carcinogenesis_Homo sapiens_hsa052030.29600563
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28134399
94Histidine metabolism_Homo sapiens_hsa003400.25258364
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25117597
96Malaria_Homo sapiens_hsa051440.24342740
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.23395965
98Asthma_Homo sapiens_hsa053100.23005345
99Apoptosis_Homo sapiens_hsa042100.21382101
100Insulin resistance_Homo sapiens_hsa049310.21115020

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