VDAC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.44663968
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.86956770
3ATP synthesis coupled proton transport (GO:0015986)7.86956770
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.61138192
5respiratory electron transport chain (GO:0022904)6.19904089
6electron transport chain (GO:0022900)6.06821976
7cullin deneddylation (GO:0010388)5.49224879
8protein neddylation (GO:0045116)5.15812067
9chaperone-mediated protein transport (GO:0072321)5.08098330
10protein deneddylation (GO:0000338)5.04129867
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.90720198
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.90720198
13NADH dehydrogenase complex assembly (GO:0010257)4.90720198
14oxidative phosphorylation (GO:0006119)4.89264550
15protein complex biogenesis (GO:0070271)4.84457883
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.75403743
17tricarboxylic acid cycle (GO:0006099)4.60583936
18mitochondrial respiratory chain complex assembly (GO:0033108)4.44923448
19ATP biosynthetic process (GO:0006754)4.37915754
20purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.20272309
21inner mitochondrial membrane organization (GO:0007007)4.17737302
22purine nucleoside triphosphate biosynthetic process (GO:0009145)4.15666585
23hydrogen ion transmembrane transport (GO:1902600)3.99669232
24energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.94862865
25ATP hydrolysis coupled proton transport (GO:0015991)3.94862865
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88780640
27regulation of cellular amino acid metabolic process (GO:0006521)3.77132419
28ribonucleoside triphosphate biosynthetic process (GO:0009201)3.69388805
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61689789
30aerobic respiration (GO:0009060)3.59533056
31GTP biosynthetic process (GO:0006183)3.58520251
32proteasome assembly (GO:0043248)3.58115860
33regulation of acyl-CoA biosynthetic process (GO:0050812)3.56432468
34NADH metabolic process (GO:0006734)3.55435701
35negative regulation of ligase activity (GO:0051352)3.54689924
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.54689924
37proton transport (GO:0015992)3.51153427
38CENP-A containing nucleosome assembly (GO:0034080)3.50636495
39chromatin remodeling at centromere (GO:0031055)3.46339954
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45856313
41regulation of coenzyme metabolic process (GO:0051196)3.45322758
42regulation of cofactor metabolic process (GO:0051193)3.45322758
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.43456736
44hydrogen transport (GO:0006818)3.42789762
45nucleoside triphosphate biosynthetic process (GO:0009142)3.42693470
46DNA ligation (GO:0006266)3.40201080
47dopamine transport (GO:0015872)3.37878143
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35836365
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35836365
50DNA double-strand break processing (GO:0000729)3.35616052
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31395286
52succinate metabolic process (GO:0006105)3.29979354
53positive regulation of mitochondrial fission (GO:0090141)3.28840627
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28135924
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28135924
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28135924
57protein targeting to mitochondrion (GO:0006626)3.21569784
58establishment of protein localization to mitochondrion (GO:0072655)3.20881349
59negative regulation of microtubule polymerization (GO:0031115)3.18608896
60regulation of mitochondrial translation (GO:0070129)3.18332068
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17889685
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.17889685
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14340707
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.14301327
65protein localization to mitochondrion (GO:0070585)3.13718252
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.12195421
67establishment of integrated proviral latency (GO:0075713)3.09672026
68purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.08439528
69purine nucleoside monophosphate biosynthetic process (GO:0009127)3.08439528
70actin-myosin filament sliding (GO:0033275)3.07858884
71muscle filament sliding (GO:0030049)3.07858884
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07284077
73cellular respiration (GO:0045333)3.03646068
74regulation of oxidative phosphorylation (GO:0002082)3.03337702
75guanosine-containing compound biosynthetic process (GO:1901070)3.02508264
76ubiquinone metabolic process (GO:0006743)3.01629757
77UTP biosynthetic process (GO:0006228)3.01074932
78respiratory chain complex IV assembly (GO:0008535)3.00526491
79heart process (GO:0003015)2.99573256
80heart contraction (GO:0060047)2.99573256
81histone exchange (GO:0043486)2.94170714
82transferrin transport (GO:0033572)2.93761792
83regulation of cellular amine metabolic process (GO:0033238)2.93655033
84positive regulation of ligase activity (GO:0051351)2.93467550
85protein-cofactor linkage (GO:0018065)2.93324463
86de novo posttranslational protein folding (GO:0051084)2.92662016
87cytochrome complex assembly (GO:0017004)2.92278141
88synapsis (GO:0007129)2.91756651
89mitochondrial transport (GO:0006839)2.91511925
90de novo protein folding (GO:0006458)2.89454970
91ubiquinone biosynthetic process (GO:0006744)2.87017023
92protein localization to cilium (GO:0061512)2.86809758
93DNA damage response, detection of DNA damage (GO:0042769)2.85264797
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84526292
95regulation of cellular respiration (GO:0043457)2.84062011
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83554719
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81588075
98establishment of viral latency (GO:0019043)2.79100465
99substantia nigra development (GO:0021762)2.76632881
1007-methylguanosine mRNA capping (GO:0006370)2.75938314
101resolution of meiotic recombination intermediates (GO:0000712)2.73122921
102regulation of ligase activity (GO:0051340)2.73039784
103RNA capping (GO:0036260)2.72213982
1047-methylguanosine RNA capping (GO:0009452)2.72213982
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72154405
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.70636575
107trivalent inorganic cation transport (GO:0072512)2.70092531
108ferric iron transport (GO:0015682)2.70092531
109nucleoside diphosphate phosphorylation (GO:0006165)2.70043601
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.69778335
111synaptic vesicle exocytosis (GO:0016079)2.69190216
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68433043
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68433043
114IMP biosynthetic process (GO:0006188)2.66667084
115UTP metabolic process (GO:0046051)2.66241021
116aldehyde catabolic process (GO:0046185)2.66022017
117protein K6-linked ubiquitination (GO:0085020)2.65780004
118regulation of cell communication by electrical coupling (GO:0010649)2.65239438
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64944583
120deoxyribose phosphate biosynthetic process (GO:0046385)2.64521979
121microtubule depolymerization (GO:0007019)2.62002724
122DNA catabolic process, exonucleolytic (GO:0000738)2.61397205
123replication fork processing (GO:0031297)2.61123303
124kinetochore assembly (GO:0051382)2.57499966
125telomere maintenance via semi-conservative replication (GO:0032201)2.57138839
126purine nucleobase biosynthetic process (GO:0009113)2.56584576
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54155558
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.54082257
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.52781679
130termination of RNA polymerase III transcription (GO:0006386)2.52781679
131IMP metabolic process (GO:0046040)2.52467258
132DNA replication-independent nucleosome organization (GO:0034724)2.51676145
133DNA replication-independent nucleosome assembly (GO:0006336)2.51676145
134branched-chain amino acid catabolic process (GO:0009083)2.51154341
135sarcoplasmic reticulum calcium ion transport (GO:0070296)2.50430323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09682464
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.35821769
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.17441009
4EZH2_22144423_ChIP-Seq_EOC_Human2.87960187
5E2F7_22180533_ChIP-Seq_HELA_Human2.85643178
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80498974
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79221884
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67949371
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67850554
10TAF15_26573619_Chip-Seq_HEK293_Human2.66870056
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62253874
12GBX2_23144817_ChIP-Seq_PC3_Human2.60156328
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57984249
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42798392
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.42739778
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39693905
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37861912
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36798616
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.20661604
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19305488
21FUS_26573619_Chip-Seq_HEK293_Human2.15855220
22* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.15041406
23VDR_22108803_ChIP-Seq_LS180_Human2.13368149
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06708440
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04614372
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.03243708
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89688955
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88163071
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87068599
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86206157
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82918195
32ELK1_19687146_ChIP-ChIP_HELA_Human1.79585504
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77793758
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77436743
35DCP1A_22483619_ChIP-Seq_HELA_Human1.73744466
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73165598
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70790217
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64935957
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64765447
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.63062185
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57957102
42VDR_23849224_ChIP-Seq_CD4+_Human1.57222821
43EWS_26573619_Chip-Seq_HEK293_Human1.57170569
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.49819153
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47986112
46P300_19829295_ChIP-Seq_ESCs_Human1.47352091
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46615086
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45194057
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.43902871
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.43689157
51* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41306462
52ZNF274_21170338_ChIP-Seq_K562_Hela1.40908393
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39342983
54ER_23166858_ChIP-Seq_MCF-7_Human1.33512245
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30973942
56TTF2_22483619_ChIP-Seq_HELA_Human1.30970987
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30408553
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29699538
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28604806
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.27695035
61RNF2_27304074_Chip-Seq_NSC_Mouse1.27599054
62IGF1R_20145208_ChIP-Seq_DFB_Human1.26604860
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26294580
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25567880
65FOXP3_21729870_ChIP-Seq_TREG_Human1.24551332
66* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22502474
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21833472
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21109737
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20717089
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20078744
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.19974544
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18450799
73* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.18110357
74AR_21909140_ChIP-Seq_LNCAP_Human1.17541547
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17245488
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17079644
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16988896
78* GABP_19822575_ChIP-Seq_HepG2_Human1.16485278
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15825341
80JUN_21703547_ChIP-Seq_K562_Human1.15205651
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15192220
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.13098829
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12479004
84REST_21632747_ChIP-Seq_MESCs_Mouse1.12471369
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12305630
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12238218
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09362853
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07643738
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05156343
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.04659390
91XRN2_22483619_ChIP-Seq_HELA_Human1.04405049
92NANOG_16153702_ChIP-ChIP_HESCs_Human1.02298490
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01567531
94SOX2_16153702_ChIP-ChIP_HESCs_Human1.00761854
95SMAD4_21799915_ChIP-Seq_A2780_Human1.00387890
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00336496
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99272218
98MYC_18940864_ChIP-ChIP_HL60_Human0.98497037
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.97353640
100E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97097938
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97049760
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96616657
103HTT_18923047_ChIP-ChIP_STHdh_Human0.95523434
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94310317
105* ELK1_22589737_ChIP-Seq_MCF10A_Human0.93124760
106IRF1_19129219_ChIP-ChIP_H3396_Human0.92816826
107CBP_20019798_ChIP-Seq_JUKART_Human0.92602147
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92602147
109SOX9_26525672_Chip-Seq_HEART_Mouse0.91564245
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89339706
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89286656
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.87730949
113TP53_22573176_ChIP-Seq_HFKS_Human0.86681288
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84955866
115NANOG_19829295_ChIP-Seq_ESCs_Human0.84775277
116SOX2_19829295_ChIP-Seq_ESCs_Human0.84775277
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84695258
118EED_16625203_ChIP-ChIP_MESCs_Mouse0.84659880
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84620448
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84221688
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.83643683
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81261770
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.81190373
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79983082
125* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79250003
126KDM5A_27292631_Chip-Seq_BREAST_Human0.78643248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.85773343
2MP0003880_abnormal_central_pattern3.83244738
3MP0008058_abnormal_DNA_repair3.29879509
4MP0002837_dystrophic_cardiac_calcinosis3.15644520
5MP0006276_abnormal_autonomic_nervous2.95803149
6MP0003646_muscle_fatigue2.82352949
7MP0000751_myopathy2.80327712
8MP0010094_abnormal_chromosome_stability2.66559417
9MP0002736_abnormal_nociception_after2.55547297
10MP0001905_abnormal_dopamine_level2.47454501
11MP0003122_maternal_imprinting2.46206970
12MP0001968_abnormal_touch/_nociception2.34783129
13MP0002822_catalepsy2.20503141
14MP0004036_abnormal_muscle_relaxation2.16824399
15MP0004215_abnormal_myocardial_fiber2.14592416
16MP0009745_abnormal_behavioral_response2.11786717
17MP0009046_muscle_twitch2.11161601
18MP0000749_muscle_degeneration2.09568627
19MP0004084_abnormal_cardiac_muscle2.09533595
20MP0002735_abnormal_chemical_nociception2.03591443
21* MP0003635_abnormal_synaptic_transmissio2.00441168
22MP0008877_abnormal_DNA_methylation1.97638647
23MP0001440_abnormal_grooming_behavior1.94834280
24* MP0006036_abnormal_mitochondrial_physio1.93560183
25MP0002734_abnormal_mechanical_nocicepti1.91406519
26MP0002064_seizures1.88666436
27MP0004859_abnormal_synaptic_plasticity1.84230932
28MP0002272_abnormal_nervous_system1.83127000
29MP0003693_abnormal_embryo_hatching1.82321312
30MP0004270_analgesia1.81290557
31MP0003806_abnormal_nucleotide_metabolis1.80962834
32MP0002572_abnormal_emotion/affect_behav1.77723862
33MP0003718_maternal_effect1.76126212
34MP0004145_abnormal_muscle_electrophysio1.74633930
35MP0003111_abnormal_nucleus_morphology1.73994493
36MP0003186_abnormal_redox_activity1.73061862
37* MP0002063_abnormal_learning/memory/cond1.72737785
38MP0002638_abnormal_pupillary_reflex1.71899299
39MP0003123_paternal_imprinting1.67991660
40MP0004142_abnormal_muscle_tone1.67225277
41MP0004924_abnormal_behavior1.67159688
42MP0005386_behavior/neurological_phenoty1.67159688
43MP0009379_abnormal_foot_pigmentation1.67082452
44MP0009697_abnormal_copulation1.60385762
45* MP0006035_abnormal_mitochondrial_morpho1.55334258
46MP0005646_abnormal_pituitary_gland1.54106939
47MP0003786_premature_aging1.52930634
48MP0003121_genomic_imprinting1.52394082
49MP0003077_abnormal_cell_cycle1.51713100
50MP0002067_abnormal_sensory_capabilities1.49527073
51MP0001984_abnormal_olfaction1.44000997
52MP0005171_absent_coat_pigmentation1.43954033
53MP0008995_early_reproductive_senescence1.42159886
54MP0000372_irregular_coat_pigmentation1.41591323
55MP0002332_abnormal_exercise_endurance1.37218067
56MP0001970_abnormal_pain_threshold1.37069608
57MP0002184_abnormal_innervation1.36153061
58MP0001188_hyperpigmentation1.34459225
59MP0008007_abnormal_cellular_replicative1.32048490
60MP0004484_altered_response_of1.31096041
61MP0005410_abnormal_fertilization1.30378373
62MP0005620_abnormal_muscle_contractility1.30139535
63MP0010386_abnormal_urinary_bladder1.29402429
64MP0002733_abnormal_thermal_nociception1.28565847
65MP0002163_abnormal_gland_morphology1.28139033
66MP0002102_abnormal_ear_morphology1.27953687
67MP0001501_abnormal_sleep_pattern1.22339980
68MP0002972_abnormal_cardiac_muscle1.19976921
69MP0004147_increased_porphyrin_level1.19086461
70MP0000778_abnormal_nervous_system1.18915940
71MP0001727_abnormal_embryo_implantation1.16610384
72MP0003221_abnormal_cardiomyocyte_apopto1.15805187
73MP0004233_abnormal_muscle_weight1.15599283
74MP0005253_abnormal_eye_physiology1.14718806
75MP0005330_cardiomyopathy1.11025909
76* MP0002106_abnormal_muscle_physiology1.10715407
77MP0001486_abnormal_startle_reflex1.09035241
78MP0002234_abnormal_pharynx_morphology1.06995257
79MP0003787_abnormal_imprinting1.06786751
80MP0002876_abnormal_thyroid_physiology1.05694355
81MP0005084_abnormal_gallbladder_morpholo1.05143644
82MP0002210_abnormal_sex_determination1.04972484
83MP0000747_muscle_weakness0.99757729
84* MP0005369_muscle_phenotype0.99044628
85* MP0001929_abnormal_gametogenesis0.98836656
86MP0003137_abnormal_impulse_conducting0.98728113
87MP0002557_abnormal_social/conspecific_i0.98702115
88MP0005551_abnormal_eye_electrophysiolog0.97730947
89MP0004085_abnormal_heartbeat0.97114719
90MP0005187_abnormal_penis_morphology0.95727077
91MP0001485_abnormal_pinna_reflex0.95512741
92* MP0000358_abnormal_cell_content/0.95337636
93MP0003011_delayed_dark_adaptation0.94334965
94MP0008932_abnormal_embryonic_tissue0.92735252
95MP0008775_abnormal_heart_ventricle0.91812823
96MP0002066_abnormal_motor_capabilities/c0.91732673
97MP0006138_congestive_heart_failure0.91489012
98MP0003567_abnormal_fetal_cardiomyocyte0.91337797
99MP0002751_abnormal_autonomic_nervous0.90957307
100MP0008057_abnormal_DNA_replication0.90025866
101MP0004811_abnormal_neuron_physiology0.88871344
102MP0002938_white_spotting0.87586901
103MP0000631_abnormal_neuroendocrine_gland0.86647033
104MP0005423_abnormal_somatic_nervous0.84961042
105MP0000653_abnormal_sex_gland0.84512176
106MP0000013_abnormal_adipose_tissue0.83510284
107MP0005266_abnormal_metabolism0.83187020
108MP0004957_abnormal_blastocyst_morpholog0.82605162
109MP0001145_abnormal_male_reproductive0.81177129
110MP0002127_abnormal_cardiovascular_syste0.81136104
111* MP0000759_abnormal_skeletal_muscle0.80470888
112MP0002882_abnormal_neuron_morphology0.79085851
113MP0005636_abnormal_mineral_homeostasis0.78486635
114MP0008789_abnormal_olfactory_epithelium0.77645042
115MP0002269_muscular_atrophy0.75786401
116MP0004087_abnormal_muscle_fiber0.74959304
117MP0006292_abnormal_olfactory_placode0.74894745
118MP0005385_cardiovascular_system_phenoty0.74435444
119MP0001544_abnormal_cardiovascular_syste0.74435444
120MP0000955_abnormal_spinal_cord0.74353053
121MP0001963_abnormal_hearing_physiology0.74151428
122MP0005645_abnormal_hypothalamus_physiol0.73806164
123MP0008872_abnormal_physiological_respon0.73534938
124* MP0003698_abnormal_male_reproductive0.73038935
125MP0006072_abnormal_retinal_apoptosis0.69680113
126MP0005499_abnormal_olfactory_system0.68678314
127MP0005394_taste/olfaction_phenotype0.68678314

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.20364924
2Abnormal mitochondria in muscle tissue (HP:0008316)6.78352079
3Progressive macrocephaly (HP:0004481)6.20022061
4Mitochondrial inheritance (HP:0001427)5.88554095
5Acute encephalopathy (HP:0006846)5.71395711
6Abnormality of glycolysis (HP:0004366)5.38658096
7Increased serum pyruvate (HP:0003542)5.38658096
8Increased CSF lactate (HP:0002490)5.33225818
9Hepatocellular necrosis (HP:0001404)5.05936808
10Hepatic necrosis (HP:0002605)4.34283474
11Exercise intolerance (HP:0003546)3.97849341
12Cerebral edema (HP:0002181)3.89455983
13Neuroendocrine neoplasm (HP:0100634)3.80358896
14Increased hepatocellular lipid droplets (HP:0006565)3.77860647
15Pheochromocytoma (HP:0002666)3.76028494
16Optic disc pallor (HP:0000543)3.61710210
17Respiratory failure (HP:0002878)3.60513821
18Lactic acidosis (HP:0003128)3.56700546
19Leukodystrophy (HP:0002415)3.49569071
20Lipid accumulation in hepatocytes (HP:0006561)3.39766273
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.36121643
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.36121643
23Hypothermia (HP:0002045)3.31229804
24Increased serum lactate (HP:0002151)3.28741681
25Focal motor seizures (HP:0011153)3.07223901
26Increased intramyocellular lipid droplets (HP:0012240)3.01477528
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96358470
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.73422587
29Exercise-induced muscle cramps (HP:0003710)2.72946591
30Atonic seizures (HP:0010819)2.71344578
31Renal Fanconi syndrome (HP:0001994)2.68761912
32Muscle hypertrophy of the lower extremities (HP:0008968)2.67965848
33Medial flaring of the eyebrow (HP:0010747)2.66669983
343-Methylglutaconic aciduria (HP:0003535)2.65178152
35Gait imbalance (HP:0002141)2.54950482
36Abnormal hair whorl (HP:0010721)2.52713666
37Increased muscle lipid content (HP:0009058)2.50712858
38Exercise-induced myalgia (HP:0003738)2.50307295
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48536981
40Abnormality of alanine metabolism (HP:0010916)2.48536981
41Hyperalaninemia (HP:0003348)2.48536981
42X-linked dominant inheritance (HP:0001423)2.48122190
43Conjunctival hamartoma (HP:0100780)2.47862018
44Calf muscle hypertrophy (HP:0008981)2.47156341
45Emotional lability (HP:0000712)2.44326015
46Methylmalonic acidemia (HP:0002912)2.40992266
47Congenital primary aphakia (HP:0007707)2.40330756
48Rimmed vacuoles (HP:0003805)2.39517540
49Palpitations (HP:0001962)2.35187358
50Respiratory difficulties (HP:0002880)2.33525233
51Nephrogenic diabetes insipidus (HP:0009806)2.30808328
52CNS demyelination (HP:0007305)2.30427484
53Limb dystonia (HP:0002451)2.30328343
54Generalized aminoaciduria (HP:0002909)2.27966733
55Neoplasm of the adrenal gland (HP:0100631)2.26408448
56Myokymia (HP:0002411)2.25856465
57Lethargy (HP:0001254)2.23199425
58Hyperglycinemia (HP:0002154)2.22156345
59Colon cancer (HP:0003003)2.19387527
60Myotonia (HP:0002486)2.19278265
61Poor suck (HP:0002033)2.18069062
62Microvesicular hepatic steatosis (HP:0001414)2.17487526
63Hypoglycemic coma (HP:0001325)2.14678602
64Delayed gross motor development (HP:0002194)2.14332318
65Absence seizures (HP:0002121)2.13108853
66Abnormality of the vocal cords (HP:0008777)2.10749191
67Degeneration of anterior horn cells (HP:0002398)2.09656647
68Abnormality of the anterior horn cell (HP:0006802)2.09656647
69Neoplasm of the peripheral nervous system (HP:0100007)2.08786140
70Exertional dyspnea (HP:0002875)2.05203856
71Type 2 muscle fiber atrophy (HP:0003554)2.00733196
72Nemaline bodies (HP:0003798)2.00552836
73Unsteady gait (HP:0002317)1.98132320
74Muscle fiber inclusion bodies (HP:0100299)1.97267642
75Methylmalonic aciduria (HP:0012120)1.96911331
76Cerebral hypomyelination (HP:0006808)1.93414958
77Hypoplastic left heart (HP:0004383)1.92829551
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.92247317
79Renal cortical cysts (HP:0000803)1.92080666
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85525953
81Dicarboxylic aciduria (HP:0003215)1.85525953
82Ragged-red muscle fibers (HP:0003200)1.85202135
83Abnormality of the calf musculature (HP:0001430)1.84969725
84Hyperventilation (HP:0002883)1.84753005
85Genital tract atresia (HP:0001827)1.83579756
86Irregular epiphyses (HP:0010582)1.83368287
87Rhabdomyolysis (HP:0003201)1.82989939
88Distal arthrogryposis (HP:0005684)1.82808096
89Shoulder girdle muscle weakness (HP:0003547)1.82243509
90Esophageal neoplasm (HP:0100751)1.82012350
91Neoplasm of head and neck (HP:0012288)1.82012350
92Hyperglycinuria (HP:0003108)1.80973839
93Delusions (HP:0000746)1.80229598
94Type I transferrin isoform profile (HP:0003642)1.79895690
95Abnormality of placental membranes (HP:0011409)1.79885317
96Amniotic constriction ring (HP:0009775)1.79885317
97Abnormality of serum amino acid levels (HP:0003112)1.79757906
98Dialeptic seizures (HP:0011146)1.78513711
99Absent/shortened dynein arms (HP:0200106)1.78453821
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.78453821
101Epileptic encephalopathy (HP:0200134)1.78280464
102Progressive inability to walk (HP:0002505)1.77622612
103Vaginal atresia (HP:0000148)1.76969430
104Abnormal pupillary function (HP:0007686)1.76966220
105Febrile seizures (HP:0002373)1.76938439
106Glycosuria (HP:0003076)1.76733486
107Abnormality of urine glucose concentration (HP:0011016)1.76733486
108Abnormal respiratory motile cilium morphology (HP:0005938)1.76100766
109Abnormal respiratory epithelium morphology (HP:0012253)1.76100766
110Pancreatic cysts (HP:0001737)1.75161871
111Abnormality of methionine metabolism (HP:0010901)1.74769773
112Generalized tonic-clonic seizures (HP:0002069)1.73802872
113Abnormality of glycine metabolism (HP:0010895)1.71844990
114Abnormality of serine family amino acid metabolism (HP:0010894)1.71844990
115Sudden death (HP:0001699)1.71757344
116Autoamputation (HP:0001218)1.71755991
117Abnormal gallbladder physiology (HP:0012438)1.71536094
118Cholecystitis (HP:0001082)1.71536094
119Myoglobinuria (HP:0002913)1.70902517
120Muscle fiber atrophy (HP:0100295)1.70819041
121Pancreatic fibrosis (HP:0100732)1.70423170
122True hermaphroditism (HP:0010459)1.70079592
123Abnormality of the labia minora (HP:0012880)1.69792312
124Poor coordination (HP:0002370)1.69678779
125Cerebral hemorrhage (HP:0001342)1.69563780
126Gliosis (HP:0002171)1.68831209
127Oligomenorrhea (HP:0000876)1.68813252
128Blindness (HP:0000618)1.67839341
129Nausea (HP:0002018)1.66880398
130Molar tooth sign on MRI (HP:0002419)1.64781848
131Abnormality of midbrain morphology (HP:0002418)1.64781848
132Meckel diverticulum (HP:0002245)1.64698532
133Abnormality of the hip-girdle musculature (HP:0001445)1.64585659
134Abnormality of the musculature of the pelvis (HP:0001469)1.64585659
135Pancreatic islet-cell hyperplasia (HP:0004510)1.64562845
136EMG: myopathic abnormalities (HP:0003458)1.63863500
137Nephronophthisis (HP:0000090)1.63032569
138Hyperinsulinemic hypoglycemia (HP:0000825)1.62750626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.96618350
2CASK3.33039658
3NME12.90663509
4PDK32.88715169
5PDK42.88715169
6VRK22.61617454
7MYLK2.47242142
8MAP2K72.45164192
9MAP3K42.40317124
10TRIM282.39575410
11STK162.36156107
12OBSCN2.35973456
13BUB12.31086473
14PLK22.23281370
15EIF2AK12.07189089
16BCKDK1.90055110
17TSSK61.90006110
18LIMK11.88958966
19PDK21.77057354
20BCR1.73335573
21MAP4K21.72901930
22ARAF1.72579160
23NUAK11.70859571
24TTK1.69830618
25NEK11.68016001
26NTRK31.57565924
27CCNB11.53426764
28MARK11.52312235
29MINK11.50440095
30MAPK131.49437909
31PNCK1.46382728
32GRK71.43487889
33VRK11.38435710
34WEE11.34930711
35STK241.33837980
36MST41.27852077
37MUSK1.26530478
38DAPK11.24807684
39GRK51.24189101
40SIK31.22074063
41MAP2K41.21659092
42PLK31.18435203
43EIF2AK31.17426530
44CSNK1G11.16486437
45PHKG21.15179137
46PHKG11.15179137
47MKNK21.10248944
48ERBB31.10008261
49TESK11.07193315
50DYRK21.05904432
51BMPR1B1.04372789
52CDK191.02230724
53BRAF1.00724266
54MKNK10.97254244
55ADRBK20.94057372
56CSNK1A1L0.90948577
57CDK80.90920879
58PBK0.90808055
59STK38L0.89725376
60CSNK1G30.88656460
61SRPK10.88498921
62OXSR10.86983630
63CAMK2A0.84076174
64TAF10.83921264
65PTK2B0.81348916
66PLK40.79487453
67MAPKAPK50.79393940
68PIK3CA0.77788410
69STK390.75470764
70ADRBK10.75133719
71PRKCG0.74045936
72ATR0.69529071
73WNK30.68322294
74UHMK10.67598898
75CAMK2B0.67274079
76ACVR1B0.67050982
77ILK0.66973079
78ZAK0.66681371
79CDK140.65680294
80CDK180.65546505
81AURKB0.63314570
82CSNK1G20.62689102
83KSR10.62356923
84CAMK2D0.60212680
85FRK0.59561628
86CDC70.58723242
87INSRR0.58309851
88TNIK0.58002358
89BMPR20.56811500
90PRKCE0.55496024
91WNK40.55423571
92CDK150.55136590
93EPHA40.54159280
94AKT30.53844901
95GRK10.52807990
96NME20.52803532
97NTRK20.50542307
98AURKA0.50219756
99BRSK20.49633842
100ERBB40.49249990
101LMTK20.48776974
102BRSK10.48757872
103ATM0.47511191
104YES10.46102990
105CDK11A0.45096618
106CHEK20.45044246
107CSNK2A20.44550166
108PLK10.44417262
109MAP3K50.43353590
110CSNK2A10.43221052
111ROCK20.43111986
112PINK10.42520515
113CAMK2G0.42292944
114PAK30.41639766
115PRKACA0.40871407
116PIM20.40529662
117STK40.40466747
118DAPK30.39364284
119DYRK30.38980254
120MAPKAPK30.38792091
121TGFBR10.38180221
122CDK50.37380978
123RPS6KA50.36131155
124EIF2AK20.35924755
125CSNK1E0.34923328
126PRKACB0.33558712
127NEK20.32388670

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.74882221
2Parkinsons disease_Homo sapiens_hsa050125.00309827
3Proteasome_Homo sapiens_hsa030504.37067882
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.77455121
5Alzheimers disease_Homo sapiens_hsa050103.73792767
6Huntingtons disease_Homo sapiens_hsa050163.58798758
7Cardiac muscle contraction_Homo sapiens_hsa042602.81528911
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.74265792
9Collecting duct acid secretion_Homo sapiens_hsa049662.55142125
10Nicotine addiction_Homo sapiens_hsa050331.96802978
11Ribosome_Homo sapiens_hsa030101.91390789
12Synaptic vesicle cycle_Homo sapiens_hsa047211.91166706
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81513822
14Pyruvate metabolism_Homo sapiens_hsa006201.79900130
15Vibrio cholerae infection_Homo sapiens_hsa051101.78092741
16RNA polymerase_Homo sapiens_hsa030201.76883880
17Protein export_Homo sapiens_hsa030601.67858885
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63206522
19Fanconi anemia pathway_Homo sapiens_hsa034601.54711039
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25648990
21Carbon metabolism_Homo sapiens_hsa012001.24884039
22One carbon pool by folate_Homo sapiens_hsa006701.19606238
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18724834
24Pyrimidine metabolism_Homo sapiens_hsa002401.16268969
25DNA replication_Homo sapiens_hsa030301.14844947
26Propanoate metabolism_Homo sapiens_hsa006401.13622694
27Fatty acid elongation_Homo sapiens_hsa000621.09835422
28Mismatch repair_Homo sapiens_hsa034301.09105496
29Nucleotide excision repair_Homo sapiens_hsa034201.08573505
30Peroxisome_Homo sapiens_hsa041461.07313437
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03873963
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02314976
33Serotonergic synapse_Homo sapiens_hsa047260.98211144
34Folate biosynthesis_Homo sapiens_hsa007900.98117475
35Steroid biosynthesis_Homo sapiens_hsa001000.95581291
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95558496
37Fatty acid metabolism_Homo sapiens_hsa012120.95343788
38Purine metabolism_Homo sapiens_hsa002300.94926814
39GABAergic synapse_Homo sapiens_hsa047270.93322592
40Amphetamine addiction_Homo sapiens_hsa050310.92367521
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91463628
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90261456
43Vitamin B6 metabolism_Homo sapiens_hsa007500.89158512
44Dopaminergic synapse_Homo sapiens_hsa047280.88858416
45Spliceosome_Homo sapiens_hsa030400.87841862
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87323366
47Basal transcription factors_Homo sapiens_hsa030220.87120533
48Nitrogen metabolism_Homo sapiens_hsa009100.86207471
49Fatty acid degradation_Homo sapiens_hsa000710.83135535
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81587733
51RNA transport_Homo sapiens_hsa030130.81310867
52Arginine and proline metabolism_Homo sapiens_hsa003300.81148736
53Phagosome_Homo sapiens_hsa041450.80757490
54RNA degradation_Homo sapiens_hsa030180.79631569
55Oocyte meiosis_Homo sapiens_hsa041140.78960680
56Rheumatoid arthritis_Homo sapiens_hsa053230.75904758
57Circadian entrainment_Homo sapiens_hsa047130.74690224
58Morphine addiction_Homo sapiens_hsa050320.74520098
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73093781
60Taste transduction_Homo sapiens_hsa047420.71601650
61beta-Alanine metabolism_Homo sapiens_hsa004100.71462652
62Long-term potentiation_Homo sapiens_hsa047200.71039578
63Tryptophan metabolism_Homo sapiens_hsa003800.70918315
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.68490470
65Olfactory transduction_Homo sapiens_hsa047400.68410284
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67854122
67Metabolic pathways_Homo sapiens_hsa011000.66886956
68Selenocompound metabolism_Homo sapiens_hsa004500.65967850
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63578212
70Homologous recombination_Homo sapiens_hsa034400.63231752
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62505598
72Biosynthesis of amino acids_Homo sapiens_hsa012300.59316807
73Sulfur metabolism_Homo sapiens_hsa009200.58488041
74Sulfur relay system_Homo sapiens_hsa041220.57665292
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56540785
76Dilated cardiomyopathy_Homo sapiens_hsa054140.55322000
77Renin secretion_Homo sapiens_hsa049240.53697741
78Butanoate metabolism_Homo sapiens_hsa006500.53606672
79Phenylalanine metabolism_Homo sapiens_hsa003600.53521876
80* Calcium signaling pathway_Homo sapiens_hsa040200.53100694
81Glutamatergic synapse_Homo sapiens_hsa047240.52902151
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52698154
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52232664
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50602027
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50105091
86Long-term depression_Homo sapiens_hsa047300.49658779
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49524071
88Tyrosine metabolism_Homo sapiens_hsa003500.48570997
89Cell cycle_Homo sapiens_hsa041100.47804193
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47741274
91Base excision repair_Homo sapiens_hsa034100.47380530
92Fructose and mannose metabolism_Homo sapiens_hsa000510.46903216
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.45658644
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44602022
95Cocaine addiction_Homo sapiens_hsa050300.44494647
96Alcoholism_Homo sapiens_hsa050340.43611928
97Circadian rhythm_Homo sapiens_hsa047100.42994265
98Oxytocin signaling pathway_Homo sapiens_hsa049210.42876516
99Phototransduction_Homo sapiens_hsa047440.40926539
100Cholinergic synapse_Homo sapiens_hsa047250.38522450
101Glutathione metabolism_Homo sapiens_hsa004800.37046551
102Gap junction_Homo sapiens_hsa045400.34401719
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33672376
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33603752
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.33380869
106Non-homologous end-joining_Homo sapiens_hsa034500.32773090
107Epstein-Barr virus infection_Homo sapiens_hsa051690.31973228
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31951501
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30300862
110Type I diabetes mellitus_Homo sapiens_hsa049400.28502639
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27296403
112Arginine biosynthesis_Homo sapiens_hsa002200.27255836
113Glucagon signaling pathway_Homo sapiens_hsa049220.25145978
114Regulation of autophagy_Homo sapiens_hsa041400.23938631
115Insulin secretion_Homo sapiens_hsa049110.22705513
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22512727
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22213639
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21590046
119Gastric acid secretion_Homo sapiens_hsa049710.21264721
120Chemical carcinogenesis_Homo sapiens_hsa052040.20928394
121Salivary secretion_Homo sapiens_hsa049700.19583465
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18710422
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.17005689
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16743378
125Pentose phosphate pathway_Homo sapiens_hsa000300.16417178
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16385789
127mRNA surveillance pathway_Homo sapiens_hsa030150.15826033

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