VDAC3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.17710082
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.53255601
3positive regulation of interleukin-8 secretion (GO:2000484)5.78600476
4regulation of regulatory T cell differentiation (GO:0045589)5.33532735
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.01165861
6neurofilament cytoskeleton organization (GO:0060052)4.87423021
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.54783578
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.54783578
9regulation of interleukin-8 secretion (GO:2000482)4.38727757
10eosinophil chemotaxis (GO:0048245)4.37807974
11pyrimidine nucleoside catabolic process (GO:0046135)4.32016069
12intestinal epithelial cell development (GO:0060576)4.16638832
13negative regulation of B cell proliferation (GO:0030889)4.16455162
14negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.16167566
15positive regulation of amino acid transport (GO:0051957)3.95911714
16eosinophil migration (GO:0072677)3.94834350
17DNA demethylation (GO:0080111)3.85019465
18regulation of cellular amino acid metabolic process (GO:0006521)3.75035435
19negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.72798070
20rRNA modification (GO:0000154)3.72525088
21regulation of meiosis I (GO:0060631)3.65513739
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54358088
23rRNA methylation (GO:0031167)3.48974762
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43806040
25platelet dense granule organization (GO:0060155)3.31811100
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.30232259
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29291133
28behavioral response to nicotine (GO:0035095)3.27550738
29negative regulation by host of viral transcription (GO:0043922)3.26695187
30neurotransmitter catabolic process (GO:0042135)3.23555570
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22699200
32DNA dealkylation (GO:0035510)3.21921533
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21309079
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21309079
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21309079
36negative regulation of calcium ion transport into cytosol (GO:0010523)3.20877577
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20438699
38pyrimidine-containing compound catabolic process (GO:0072529)3.20010787
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19757352
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19757352
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16519343
42pyrimidine ribonucleoside metabolic process (GO:0046131)3.13721930
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10280646
44protein neddylation (GO:0045116)3.09260109
45regulation of action potential (GO:0098900)3.08477667
46regulation of chemokine-mediated signaling pathway (GO:0070099)3.08395972
47iron-sulfur cluster assembly (GO:0016226)3.07488159
48metallo-sulfur cluster assembly (GO:0031163)3.07488159
49positive regulation of interleukin-1 beta secretion (GO:0050718)3.03080001
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02981683
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.02981683
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.02413393
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99434201
54positive regulation of B cell differentiation (GO:0045579)2.94184464
55positive regulation of lymphocyte migration (GO:2000403)2.94041269
56negative regulation of ligase activity (GO:0051352)2.93802459
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93802459
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90896496
59positive regulation of T cell migration (GO:2000406)2.89064101
60energy coupled proton transport, down electrochemical gradient (GO:0015985)2.86996346
61ATP synthesis coupled proton transport (GO:0015986)2.86996346
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86768168
63positive regulation of defense response to virus by host (GO:0002230)2.86129720
64regulation of T cell migration (GO:2000404)2.85734112
65negative regulation of T cell apoptotic process (GO:0070233)2.84982667
66signal peptide processing (GO:0006465)2.84948900
67positive regulation of interleukin-1 secretion (GO:0050716)2.84248565
68respiratory electron transport chain (GO:0022904)2.82310569
69negative regulation of B cell activation (GO:0050869)2.82225572
70positive regulation of T cell chemotaxis (GO:0010820)2.81819959
71regulation of T cell chemotaxis (GO:0010819)2.81819959
72electron transport chain (GO:0022900)2.81345238
73monocyte chemotaxis (GO:0002548)2.81134255
74positive regulation of T cell apoptotic process (GO:0070234)2.79412302
75protein localization to microtubule (GO:0035372)2.79406693
76positive regulation of translational initiation (GO:0045948)2.79096054
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78345101
78regulation of interleukin-1 beta secretion (GO:0050706)2.77234475
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75462540
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75101988
81single strand break repair (GO:0000012)2.73073869
82DNA strand renaturation (GO:0000733)2.71079490
83proteasome assembly (GO:0043248)2.70130956
84GPI anchor metabolic process (GO:0006505)2.69498605
85positive regulation of ligase activity (GO:0051351)2.68940720
86positive regulation of organic acid transport (GO:0032892)2.68270236
87positive regulation of action potential (GO:0045760)2.67526136
88response to pheromone (GO:0019236)2.65924012
89antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62954192
90preassembly of GPI anchor in ER membrane (GO:0016254)2.62854494
91regulation of cellular amine metabolic process (GO:0033238)2.61906227
92negative regulation of viral genome replication (GO:0045071)2.61375866
93positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.58384715
94cytolysis (GO:0019835)2.58241864
95positive regulation of cell killing (GO:0031343)2.57958247
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56974830
97cytidine metabolic process (GO:0046087)10.3966957
98cytidine catabolic process (GO:0006216)10.3966957
99cytidine deamination (GO:0009972)10.3966957
100DNA deamination (GO:0045006)10.0789791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.91509341
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52299077
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.36496210
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.30035093
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85073799
6VDR_22108803_ChIP-Seq_LS180_Human2.82049605
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.79749884
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.60162281
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54576093
10EZH2_22144423_ChIP-Seq_EOC_Human2.50609240
11ZNF274_21170338_ChIP-Seq_K562_Hela2.40266532
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37813801
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37656929
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33877850
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.32100690
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28699333
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.26741854
18TAF15_26573619_Chip-Seq_HEK293_Human2.26653038
19IGF1R_20145208_ChIP-Seq_DFB_Human2.09383419
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04944835
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03902888
22GBX2_23144817_ChIP-Seq_PC3_Human1.90019341
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87569846
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83206873
25VDR_23849224_ChIP-Seq_CD4+_Human1.75761828
26P300_19829295_ChIP-Seq_ESCs_Human1.74469276
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72202750
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66573597
29FUS_26573619_Chip-Seq_HEK293_Human1.66430809
30NANOG_19829295_ChIP-Seq_ESCs_Human1.64384734
31SOX2_19829295_ChIP-Seq_ESCs_Human1.64384734
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.63651725
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.63538991
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57122344
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.54516832
36ELK1_19687146_ChIP-ChIP_HELA_Human1.52718482
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.50888976
38EWS_26573619_Chip-Seq_HEK293_Human1.49705661
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.49456892
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49279832
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48650015
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.46087333
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44772402
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44399484
45TP53_22573176_ChIP-Seq_HFKS_Human1.39855034
46ER_23166858_ChIP-Seq_MCF-7_Human1.37709902
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35479539
48IRF1_19129219_ChIP-ChIP_H3396_Human1.34271026
49HTT_18923047_ChIP-ChIP_STHdh_Human1.33966917
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31203627
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27677983
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26068217
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25163866
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22963841
55AR_21572438_ChIP-Seq_LNCaP_Human1.21289142
56BCAT_22108803_ChIP-Seq_LS180_Human1.21105757
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20038944
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.18875656
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17881460
60SMAD4_21799915_ChIP-Seq_A2780_Human1.15464503
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14182729
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.14025934
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.13785403
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13785403
65FOXH1_21741376_ChIP-Seq_EPCs_Human1.13763642
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13490758
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.10181332
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08046531
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07513655
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07270109
71FOXP3_21729870_ChIP-Seq_TREG_Human1.06612302
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06383198
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05933644
74P300_18555785_Chip-Seq_ESCs_Mouse1.05685099
75RUNX2_22187159_ChIP-Seq_PCA_Human1.04469536
76P53_22387025_ChIP-Seq_ESCs_Mouse1.04132080
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.03775489
78TCF4_22108803_ChIP-Seq_LS180_Human1.03287892
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03051039
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03037861
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02880001
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02768231
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.02018895
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01882318
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99856572
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97197752
87NCOR_22424771_ChIP-Seq_293T_Human0.97046790
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96491393
89SMAD_19615063_ChIP-ChIP_OVARY_Human0.96404946
90MYC_18940864_ChIP-ChIP_HL60_Human0.96393438
91SOX2_18555785_Chip-Seq_ESCs_Mouse0.96104109
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95777423
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95763209
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.95683092
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.95474097
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94763704
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94419065
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.94034363
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92575054
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92490727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.13820859
2MP0002735_abnormal_chemical_nociception3.82461129
3MP0002736_abnormal_nociception_after2.82587616
4MP0000372_irregular_coat_pigmentation2.60719486
5MP0001968_abnormal_touch/_nociception2.38352202
6MP0006082_CNS_inflammation2.27369138
7MP0010386_abnormal_urinary_bladder2.26778949
8MP0005075_abnormal_melanosome_morpholog2.21634943
9MP0006036_abnormal_mitochondrial_physio2.17744185
10MP0009785_altered_susceptibility_to2.10372739
11MP0004145_abnormal_muscle_electrophysio2.07442892
12MP0006035_abnormal_mitochondrial_morpho1.95721261
13MP0002638_abnormal_pupillary_reflex1.90591296
14MP0003011_delayed_dark_adaptation1.85960910
15MP0009333_abnormal_splenocyte_physiolog1.84653046
16MP0008872_abnormal_physiological_respon1.75422095
17MP0002272_abnormal_nervous_system1.69945922
18MP0005377_hearing/vestibular/ear_phenot1.68657053
19MP0003878_abnormal_ear_physiology1.68657053
20MP0001873_stomach_inflammation1.53839659
21MP0002095_abnormal_skin_pigmentation1.50658614
22MP0009046_muscle_twitch1.48746419
23MP0001919_abnormal_reproductive_system1.45985551
24MP0003763_abnormal_thymus_physiology1.45115432
25MP0001970_abnormal_pain_threshold1.41935879
26MP0002163_abnormal_gland_morphology1.41905499
27MP0005083_abnormal_biliary_tract1.41867775
28MP0001835_abnormal_antigen_presentation1.39761562
29MP0006054_spinal_hemorrhage1.39266200
30MP0005387_immune_system_phenotype1.38980008
31MP0001790_abnormal_immune_system1.38980008
32MP0002148_abnormal_hypersensitivity_rea1.33666545
33MP0000685_abnormal_immune_system1.33478322
34MP0002102_abnormal_ear_morphology1.31495884
35MP0001486_abnormal_startle_reflex1.30279674
36MP0001905_abnormal_dopamine_level1.29367237
37MP0004142_abnormal_muscle_tone1.28681020
38MP0002234_abnormal_pharynx_morphology1.28360472
39MP0009745_abnormal_behavioral_response1.28319954
40MP0005551_abnormal_eye_electrophysiolog1.27155233
41MP0005423_abnormal_somatic_nervous1.26843742
42MP0004147_increased_porphyrin_level1.24851023
43MP0004215_abnormal_myocardial_fiber1.24588452
44MP0001485_abnormal_pinna_reflex1.24490723
45MP0002572_abnormal_emotion/affect_behav1.20656070
46MP0008058_abnormal_DNA_repair1.19381251
47MP0005410_abnormal_fertilization1.16974215
48MP0002277_abnormal_respiratory_mucosa1.16190595
49MP0005000_abnormal_immune_tolerance1.16168253
50MP0001800_abnormal_humoral_immune1.16079447
51MP0005646_abnormal_pituitary_gland1.14957008
52MP0004036_abnormal_muscle_relaxation1.13595729
53MP0003866_abnormal_defecation1.13332882
54MP0005253_abnormal_eye_physiology1.13207989
55MP0005645_abnormal_hypothalamus_physiol1.12846086
56MP0004924_abnormal_behavior1.12223618
57MP0005386_behavior/neurological_phenoty1.12223618
58MP0001986_abnormal_taste_sensitivity1.09705121
59MP0003635_abnormal_synaptic_transmissio1.06576088
60MP0002733_abnormal_thermal_nociception1.06022985
61MP0002837_dystrophic_cardiac_calcinosis1.05584127
62MP0009765_abnormal_xenobiotic_induced1.05535331
63MP0003880_abnormal_central_pattern1.05176297
64MP0003137_abnormal_impulse_conducting1.05109657
65MP0005174_abnormal_tail_pigmentation1.04824534
66MP0002693_abnormal_pancreas_physiology1.01865820
67MP0003195_calcinosis1.00647733
68MP0002064_seizures0.99936388
69MP0008873_increased_physiological_sensi0.98041958
70MP0005025_abnormal_response_to0.97669499
71MP0002063_abnormal_learning/memory/cond0.96738954
72MP0002723_abnormal_immune_serum0.95949538
73MP0004885_abnormal_endolymph0.95768282
74MP0008875_abnormal_xenobiotic_pharmacok0.94373710
75MP0002067_abnormal_sensory_capabilities0.93540239
76MP0002876_abnormal_thyroid_physiology0.93509061
77MP0005389_reproductive_system_phenotype0.93230186
78MP0002734_abnormal_mechanical_nocicepti0.93205991
79MP0001661_extended_life_span0.93045009
80MP0002229_neurodegeneration0.92805400
81MP0002282_abnormal_trachea_morphology0.92605793
82MP0000569_abnormal_digit_pigmentation0.91823406
83MP0002933_joint_inflammation0.91050681
84MP0002420_abnormal_adaptive_immunity0.90755779
85MP0005167_abnormal_blood-brain_barrier0.90534130
86MP0002557_abnormal_social/conspecific_i0.89711893
87MP0001819_abnormal_immune_cell0.87489620
88MP0002090_abnormal_vision0.85345023
89MP0003786_premature_aging0.84226146
90MP0001764_abnormal_homeostasis0.81334860
91MP0000703_abnormal_thymus_morphology0.81095320
92MP0003567_abnormal_fetal_cardiomyocyte0.80746127
93MP0004084_abnormal_cardiac_muscle0.80625045
94MP0003718_maternal_effect0.79489680
95MP0003045_fibrosis0.79140630
96MP0008569_lethality_at_weaning0.79138170
97MP0006072_abnormal_retinal_apoptosis0.78642987
98MP0005379_endocrine/exocrine_gland_phen0.78007139
99MP0002396_abnormal_hematopoietic_system0.77897012
100MP0005084_abnormal_gallbladder_morpholo0.77373142

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.26720098
2Acute necrotizing encephalopathy (HP:0006965)4.80367521
3Abnormal mitochondria in muscle tissue (HP:0008316)4.39568827
4Progressive macrocephaly (HP:0004481)4.27762909
5Mitochondrial inheritance (HP:0001427)4.16268993
6Acute encephalopathy (HP:0006846)4.10588968
7Ulnar claw (HP:0001178)3.98867751
8Hypoproteinemia (HP:0003075)3.76899556
9Increased CSF lactate (HP:0002490)3.64976449
10Hypothermia (HP:0002045)3.60077075
11Hepatocellular necrosis (HP:0001404)3.56074696
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41630082
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41630082
14Hypoalbuminemia (HP:0003073)3.36154609
15Abnormal albumin level (HP:0012116)3.36154609
16Abnormality of midbrain morphology (HP:0002418)3.29344796
17Molar tooth sign on MRI (HP:0002419)3.29344796
18Abnormality of the pons (HP:0007361)3.28106369
19Abnormality of the prostate (HP:0008775)3.26938352
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.16666309
21Autoimmune hemolytic anemia (HP:0001890)3.16142593
22Amyotrophic lateral sclerosis (HP:0007354)3.12525277
23Hepatic necrosis (HP:0002605)3.03388666
24Cerebral edema (HP:0002181)3.01571216
25Congenital stationary night blindness (HP:0007642)2.90862314
26Pulmonary fibrosis (HP:0002206)2.86188933
27Colon cancer (HP:0003003)2.85985396
28Oral leukoplakia (HP:0002745)2.80538708
29Hypoplasia of the pons (HP:0012110)2.67322964
30Seborrheic dermatitis (HP:0001051)2.61234922
31Increased hepatocellular lipid droplets (HP:0006565)2.56028066
32Optic disc pallor (HP:0000543)2.54188616
33Renal cortical cysts (HP:0000803)2.50691595
34Lethargy (HP:0001254)2.48072151
35Pendular nystagmus (HP:0012043)2.41865913
36Increased serum lactate (HP:0002151)2.40012437
37Neoplasm of the adrenal cortex (HP:0100641)2.36921341
38Increased intramyocellular lipid droplets (HP:0012240)2.36634757
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34233372
40Atrophy/Degeneration involving motor neurons (HP:0007373)2.34072715
41IgG deficiency (HP:0004315)2.32920375
42Renal Fanconi syndrome (HP:0001994)2.30040300
43Chest pain (HP:0100749)2.29888437
44Thyroiditis (HP:0100646)2.28276608
45Ketoacidosis (HP:0001993)2.26351561
46Lipid accumulation in hepatocytes (HP:0006561)2.23712461
47Aplastic anemia (HP:0001915)2.23546809
48Severe combined immunodeficiency (HP:0004430)2.20460817
49Exercise intolerance (HP:0003546)2.20319220
50Cerebral hypomyelination (HP:0006808)2.18771141
51Abolished electroretinogram (ERG) (HP:0000550)2.17749322
52Lactic acidosis (HP:0003128)2.17282057
53Leukodystrophy (HP:0002415)2.16803647
54Ketosis (HP:0001946)2.15465401
55Ureteral stenosis (HP:0000071)2.14731098
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.12074744
57Encephalitis (HP:0002383)2.09944682
58Focal motor seizures (HP:0011153)2.07477718
59Generalized aminoaciduria (HP:0002909)2.04912116
60Respiratory failure (HP:0002878)2.02514891
61Hematochezia (HP:0002573)2.00766842
62Large for gestational age (HP:0001520)1.98093333
63Progressive external ophthalmoplegia (HP:0000590)1.97872571
64Attenuation of retinal blood vessels (HP:0007843)1.97821868
65Methylmalonic acidemia (HP:0002912)1.97216865
66Upper limb muscle weakness (HP:0003484)1.97164581
67Limb dystonia (HP:0002451)1.96171791
68Nephronophthisis (HP:0000090)1.95800205
69Tachypnea (HP:0002789)1.95203384
70Ureteral obstruction (HP:0006000)1.92521345
71Gangrene (HP:0100758)1.92094198
72Gaze-evoked nystagmus (HP:0000640)1.90632233
73Abnormality of T cells (HP:0002843)1.90038490
74Stomatitis (HP:0010280)1.89399389
75Abnormality of the corticospinal tract (HP:0002492)1.88746739
76Panhypogammaglobulinemia (HP:0003139)1.85429824
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85170735
78Atonic seizures (HP:0010819)1.85139953
79Erythroderma (HP:0001019)1.80719278
80Opisthotonus (HP:0002179)1.80473664
81Stomach cancer (HP:0012126)1.79035199
82Severe visual impairment (HP:0001141)1.78235837
83Amaurosis fugax (HP:0100576)1.77146097
84Morphological abnormality of the pyramidal tract (HP:0002062)1.77066813
85Increased muscle lipid content (HP:0009058)1.76486180
86X-linked dominant inheritance (HP:0001423)1.76330660
87Methylmalonic aciduria (HP:0012120)1.76234237
88Emotional lability (HP:0000712)1.74729812
89Abnormality of T cell number (HP:0011839)1.73410588
90CNS demyelination (HP:0007305)1.72911169
91Pancreatic cysts (HP:0001737)1.71651596
92T lymphocytopenia (HP:0005403)1.70961653
93Progressive microcephaly (HP:0000253)1.70021572
94CNS hypomyelination (HP:0003429)1.67585186
95Meningitis (HP:0001287)1.67297336
96Abnormality of the labia minora (HP:0012880)1.67224949
97Cerebral palsy (HP:0100021)1.66814996
98Bifid tongue (HP:0010297)1.66047859
99Congenital sensorineural hearing impairment (HP:0008527)1.65731476
100Hemoptysis (HP:0002105)1.65111628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.96961405
2BMPR1B3.13653200
3PNCK3.01136287
4MST42.86389719
5VRK22.84390426
6TRIM282.80850965
7TIE12.46827269
8TAF12.42760090
9NUAK12.36377344
10EIF2AK32.35477377
11FRK2.32554564
12GRK12.25095587
13ADRBK22.19672286
14KDR2.04024167
15MAP3K122.02910445
16STK162.00270846
17TSSK61.97140383
18MAP2K71.94965882
19WNK31.75900403
20VRK11.71958692
21PIK3CA1.62327149
22MINK11.61482861
23MARK11.58377197
24BCKDK1.58344720
25ERBB31.50859614
26ZAK1.50704790
27DYRK21.46918615
28ACVR1B1.28934129
29EIF2AK11.26848454
30FES1.24802707
31EIF2AK21.24412265
32ITK1.22328408
33BUB11.21677878
34CSNK1G21.17145783
35CSNK1A1L1.16260591
36PIK3CG1.15738064
37MAP4K21.13282420
38CSNK1G31.10682704
39PLK31.08391717
40CSNK1G11.08022304
41GRK50.91274101
42DAPK10.88891844
43NEK10.87169321
44TYRO30.86980557
45MAP2K60.86621838
46PRKCG0.85482153
47TEC0.78620249
48EPHA40.75057459
49WNK40.74347178
50PRKCQ0.73569159
51INSRR0.71538299
52MAP3K50.70815411
53PLK20.68650301
54RPS6KB10.64027726
55CAMK1G0.62729097
56LIMK10.60752439
57CAMK2A0.60051094
58ADRBK10.59559411
59BCR0.59461784
60PHKG20.59288683
61PHKG10.59288683
62SYK0.59180435
63TAOK30.56552560
64MAPK130.55863862
65PIM20.52656409
66GSK3A0.50672629
67IKBKB0.50264319
68OBSCN0.48111727
69OXSR10.46597727
70LCK0.45881647
71MAPKAPK50.45226819
72DAPK20.43224655
73PRKCE0.41084661
74IGF1R0.40744428
75CLK10.39650722
76FGFR20.38830050
77GRK70.38653892
78MKNK20.37865430
79WNK10.36433518
80CSNK1A10.34825222
81SGK20.34752018
82ATR0.33386162
83PRKCH0.31582468
84PRKCA0.31401328
85AURKA0.31288834
86SRPK10.31172603
87MYLK0.31022593
88NEK90.30511278
89MKNK10.30440638
90BMPR20.29943952
91PRKACA0.29227684
92LYN0.24705932
93PRKG10.23727863
94CDK30.22294186
95TGFBR10.22061344
96CSF1R0.21739306
97ATM0.21681414
98PLK40.21638275
99KIT0.21262288
100PRKACB0.21205809

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.86468220
2Oxidative phosphorylation_Homo sapiens_hsa001903.55294652
3Graft-versus-host disease_Homo sapiens_hsa053322.96056013
4Parkinsons disease_Homo sapiens_hsa050122.93881420
5Primary immunodeficiency_Homo sapiens_hsa053402.79195516
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78767413
7Autoimmune thyroid disease_Homo sapiens_hsa053202.63918269
8Protein export_Homo sapiens_hsa030602.56847764
9Allograft rejection_Homo sapiens_hsa053302.22842869
10Alzheimers disease_Homo sapiens_hsa050102.11642288
11Rheumatoid arthritis_Homo sapiens_hsa053232.09777365
12RNA polymerase_Homo sapiens_hsa030202.06406237
13Type I diabetes mellitus_Homo sapiens_hsa049402.04771429
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98729146
15Phototransduction_Homo sapiens_hsa047441.95001186
16Antigen processing and presentation_Homo sapiens_hsa046121.89699423
17Huntingtons disease_Homo sapiens_hsa050161.86717103
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78074254
19Basal transcription factors_Homo sapiens_hsa030221.58916792
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48847002
21RNA degradation_Homo sapiens_hsa030181.48036905
22Non-homologous end-joining_Homo sapiens_hsa034501.42103386
23Hematopoietic cell lineage_Homo sapiens_hsa046401.23709975
24Nitrogen metabolism_Homo sapiens_hsa009101.19881533
25Collecting duct acid secretion_Homo sapiens_hsa049661.19389165
26Propanoate metabolism_Homo sapiens_hsa006401.17978156
27Cardiac muscle contraction_Homo sapiens_hsa042601.16805723
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.14544534
29Nicotine addiction_Homo sapiens_hsa050331.14286454
30Peroxisome_Homo sapiens_hsa041461.13760383
31Fatty acid elongation_Homo sapiens_hsa000621.11275325
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09479917
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03902031
34Caffeine metabolism_Homo sapiens_hsa002321.02354501
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99158985
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96026675
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94823312
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94493286
39GABAergic synapse_Homo sapiens_hsa047270.94382147
40Morphine addiction_Homo sapiens_hsa050320.89729293
41Butanoate metabolism_Homo sapiens_hsa006500.86503568
42Vitamin digestion and absorption_Homo sapiens_hsa049770.84720413
43Regulation of autophagy_Homo sapiens_hsa041400.84307918
44Linoleic acid metabolism_Homo sapiens_hsa005910.81652877
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78995574
46Taste transduction_Homo sapiens_hsa047420.78504031
47Asthma_Homo sapiens_hsa053100.75300738
48Steroid biosynthesis_Homo sapiens_hsa001000.75296819
49T cell receptor signaling pathway_Homo sapiens_hsa046600.74701252
50Tryptophan metabolism_Homo sapiens_hsa003800.74077434
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.73780116
52Ether lipid metabolism_Homo sapiens_hsa005650.72894253
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71377224
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70087806
55Purine metabolism_Homo sapiens_hsa002300.68317472
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67324169
57Homologous recombination_Homo sapiens_hsa034400.65592403
58Pyrimidine metabolism_Homo sapiens_hsa002400.65536349
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65250551
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64671248
61Olfactory transduction_Homo sapiens_hsa047400.63929357
62Selenocompound metabolism_Homo sapiens_hsa004500.60661825
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60441180
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56374096
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56257400
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.54179994
67Retinol metabolism_Homo sapiens_hsa008300.53202482
68Measles_Homo sapiens_hsa051620.52833762
69Circadian rhythm_Homo sapiens_hsa047100.52795803
70Vitamin B6 metabolism_Homo sapiens_hsa007500.52471877
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52144365
72Glutamatergic synapse_Homo sapiens_hsa047240.51548419
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51298849
74Pyruvate metabolism_Homo sapiens_hsa006200.49954239
75Metabolic pathways_Homo sapiens_hsa011000.49747426
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49700176
77One carbon pool by folate_Homo sapiens_hsa006700.48568598
78beta-Alanine metabolism_Homo sapiens_hsa004100.47047808
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.45544945
80Fatty acid metabolism_Homo sapiens_hsa012120.45212052
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44886575
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41869797
83RNA transport_Homo sapiens_hsa030130.38992896
84Pancreatic secretion_Homo sapiens_hsa049720.37841338
85Salmonella infection_Homo sapiens_hsa051320.37769188
86Viral myocarditis_Homo sapiens_hsa054160.37177805
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37133079
88Epstein-Barr virus infection_Homo sapiens_hsa051690.36363548
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35842979
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35428985
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35001495
92Salivary secretion_Homo sapiens_hsa049700.34931765
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34912410
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34535477
95Insulin secretion_Homo sapiens_hsa049110.32591279
96Calcium signaling pathway_Homo sapiens_hsa040200.31767580
97Circadian entrainment_Homo sapiens_hsa047130.30930545
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29352484
99Fanconi anemia pathway_Homo sapiens_hsa034600.28393667
100Spliceosome_Homo sapiens_hsa030400.27453054

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