VEGFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.83575621
2glomerular visceral epithelial cell development (GO:0072015)4.53272016
3skin morphogenesis (GO:0043589)4.06085733
4glomerular epithelial cell development (GO:0072310)4.01418355
5regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.00868647
6positive regulation of fatty acid beta-oxidation (GO:0032000)3.83337820
7alpha-linolenic acid metabolic process (GO:0036109)3.71313640
8glomerular basement membrane development (GO:0032836)3.67695625
9lysine metabolic process (GO:0006553)3.63524131
10lysine catabolic process (GO:0006554)3.63524131
114-hydroxyproline metabolic process (GO:0019471)3.54005815
12peptidyl-proline hydroxylation (GO:0019511)3.48188403
13positive regulation of fatty acid oxidation (GO:0046321)3.44971421
14fatty acid transmembrane transport (GO:1902001)3.43558552
15regulation of cholesterol homeostasis (GO:2000188)3.41170381
16carnitine shuttle (GO:0006853)3.39324490
17hemidesmosome assembly (GO:0031581)3.33688917
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32201567
19L-phenylalanine catabolic process (GO:0006559)3.30298223
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.30298223
21negative regulation of fatty acid transport (GO:2000192)3.30239814
22regulation of fatty acid beta-oxidation (GO:0031998)3.29843704
23regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.27621219
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.20211197
25L-phenylalanine metabolic process (GO:0006558)3.20211197
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.14383611
27regulation of fatty acid oxidation (GO:0046320)3.14242376
282-oxoglutarate metabolic process (GO:0006103)3.12490562
29fatty acid beta-oxidation (GO:0006635)3.11669165
30protein retention in ER lumen (GO:0006621)3.09819400
31basement membrane organization (GO:0071711)3.07576644
32protein hydroxylation (GO:0018126)3.06023367
33* surfactant homeostasis (GO:0043129)3.05482718
34* endothelial cell chemotaxis (GO:0035767)3.05168445
35low-density lipoprotein particle clearance (GO:0034383)3.03878903
36positive regulation of glycogen biosynthetic process (GO:0045725)3.03829324
37desmosome organization (GO:0002934)3.02568596
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02511317
39negative regulation of fibrinolysis (GO:0051918)3.01548129
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.00686866
41embryonic retina morphogenesis in camera-type eye (GO:0060059)3.00216492
42peptidyl-glutamic acid carboxylation (GO:0017187)2.97817204
43protein carboxylation (GO:0018214)2.97817204
44regulation of sequestering of triglyceride (GO:0010889)2.94904636
45semaphorin-plexin signaling pathway (GO:0071526)2.94356240
46fatty acid oxidation (GO:0019395)2.92548459
47histone H3-K9 demethylation (GO:0033169)2.92532432
48glucose 6-phosphate metabolic process (GO:0051156)2.89898559
49regulation of glucose import in response to insulin stimulus (GO:2001273)2.88854628
50tricarboxylic acid metabolic process (GO:0072350)2.88806351
51lipid oxidation (GO:0034440)2.87857229
52cell-substrate junction assembly (GO:0007044)2.84842559
53valine metabolic process (GO:0006573)2.84779951
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83853679
55atrioventricular valve morphogenesis (GO:0003181)2.83402452
56glyoxylate metabolic process (GO:0046487)2.79886578
57regulation of phospholipase A2 activity (GO:0032429)2.79664665
58positive regulation of lipid catabolic process (GO:0050996)2.78957384
59regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76942396
60cytoskeletal anchoring at plasma membrane (GO:0007016)2.76792984
61positive regulation of glycogen metabolic process (GO:0070875)2.76436294
62plasma lipoprotein particle clearance (GO:0034381)2.76348476
63regulation of triglyceride catabolic process (GO:0010896)2.75567065
64short-chain fatty acid metabolic process (GO:0046459)2.75296281
65positive regulation of glycolytic process (GO:0045821)2.74587378
66plasma membrane repair (GO:0001778)2.71433060
67aromatic amino acid family catabolic process (GO:0009074)2.69587834
68fatty acid catabolic process (GO:0009062)2.69582490
69kynurenine metabolic process (GO:0070189)2.67326228
70* positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.66827741
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66024535
72aspartate family amino acid catabolic process (GO:0009068)2.65356554
73positive regulation of fatty acid metabolic process (GO:0045923)2.64704203
74phospholipid homeostasis (GO:0055091)2.64478741
75amino-acid betaine metabolic process (GO:0006577)2.64463554
76COPI coating of Golgi vesicle (GO:0048205)2.63231852
77Golgi transport vesicle coating (GO:0048200)2.63231852
78complement activation, alternative pathway (GO:0006957)2.63159449
79carnitine transmembrane transport (GO:1902603)2.63146995
80biotin metabolic process (GO:0006768)2.61723280
81acetyl-CoA metabolic process (GO:0006084)2.61518887
82regulation of fibrinolysis (GO:0051917)2.60828587
83positive regulation of triglyceride metabolic process (GO:0090208)2.60330749
84high-density lipoprotein particle remodeling (GO:0034375)2.59908227
85triglyceride homeostasis (GO:0070328)2.59429175
86acylglycerol homeostasis (GO:0055090)2.59429175
87epithelial cell-cell adhesion (GO:0090136)2.59099271
88amino-acid betaine transport (GO:0015838)2.59036835
89carnitine transport (GO:0015879)2.59036835
90sarcomere organization (GO:0045214)2.58910389
91endocardial cushion morphogenesis (GO:0003203)2.58003454
92sulfur amino acid catabolic process (GO:0000098)2.57742591
93endodermal cell differentiation (GO:0035987)2.56079496
94drug catabolic process (GO:0042737)2.55615879
95Notch signaling involved in heart development (GO:0061314)2.55608600
96cardiac myofibril assembly (GO:0055003)2.54385579
97positive regulation of triglyceride biosynthetic process (GO:0010867)2.54208541
98dicarboxylic acid biosynthetic process (GO:0043650)2.53955962
99regulation of triglyceride biosynthetic process (GO:0010866)2.53585842
100bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53279845
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.52680546
102metanephric nephron epithelium development (GO:0072243)2.52652451
103regulation of protein activation cascade (GO:2000257)2.52583684
104retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52364755
105collagen fibril organization (GO:0030199)2.52197334
106regulation of apoptotic cell clearance (GO:2000425)2.52148422
107homocysteine metabolic process (GO:0050667)2.52033024
108metanephric tubule development (GO:0072170)2.50933168
109metanephric nephron tubule development (GO:0072234)2.50933168
110macroautophagy (GO:0016236)2.50357202
111cysteine metabolic process (GO:0006534)2.48821222
112adherens junction assembly (GO:0034333)2.47320561
113regulation of extracellular matrix disassembly (GO:0010715)2.47223071
114monocarboxylic acid catabolic process (GO:0072329)2.47055301
115apoptotic cell clearance (GO:0043277)2.46211095
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.45835053
117carnitine metabolic process (GO:0009437)2.45397175
118protein heterotrimerization (GO:0070208)2.44906849
119* chemical homeostasis within a tissue (GO:0048875)2.44485749
120regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44312682
121bile acid biosynthetic process (GO:0006699)2.44139026
122phosphate ion transmembrane transport (GO:0035435)2.44018624
123regulation of complement activation (GO:0030449)2.41924337
124reverse cholesterol transport (GO:0043691)2.41865672
125regulation of cholesterol storage (GO:0010885)2.40624291
126intracellular lipid transport (GO:0032365)2.40150100
127intestinal cholesterol absorption (GO:0030299)2.40090274
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.39907712
129cellular modified amino acid catabolic process (GO:0042219)2.39831835
130positive regulation of catenin import into nucleus (GO:0035413)2.39295415
131positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.39215138
132cellular response to epidermal growth factor stimulus (GO:0071364)2.38894274
133fatty acid homeostasis (GO:0055089)2.38640532
134collagen metabolic process (GO:0032963)2.38452017
135iron ion import (GO:0097286)2.37970144
136cell-substrate adherens junction assembly (GO:0007045)2.37803411
137focal adhesion assembly (GO:0048041)2.37803411
138positive regulation of extracellular matrix organization (GO:1903055)2.37082160
139nephron tubule development (GO:0072080)2.36453112
140cell adhesion mediated by integrin (GO:0033627)2.36288270
141growth hormone receptor signaling pathway (GO:0060396)2.35291395
142regulation of extracellular matrix organization (GO:1903053)2.35051336
143cellular response to growth hormone stimulus (GO:0071378)2.34985067
144negative regulation of catenin import into nucleus (GO:0035414)2.34816256
145positive regulation of osteoblast proliferation (GO:0033690)2.34660224
146negative regulation of fatty acid biosynthetic process (GO:0045717)2.34567446
147collagen catabolic process (GO:0030574)2.34375116
148urea metabolic process (GO:0019627)2.33853942
149urea cycle (GO:0000050)2.33853942
150regulation of triglyceride metabolic process (GO:0090207)2.33470167
151hormone catabolic process (GO:0042447)2.33358829
152negative regulation of lipase activity (GO:0060192)2.33038161
153metanephric epithelium development (GO:0072207)2.32656546
154cellular ketone body metabolic process (GO:0046950)2.32038872
155protein-lipid complex remodeling (GO:0034368)2.31508287
156macromolecular complex remodeling (GO:0034367)2.31508287
157plasma lipoprotein particle remodeling (GO:0034369)2.31508287
158cochlea morphogenesis (GO:0090103)2.29515692
159multicellular organismal macromolecule metabolic process (GO:0044259)2.29383656
160* regulation of p38MAPK cascade (GO:1900744)2.27893089
161protein localization to endosome (GO:0036010)2.25316630
162import into cell (GO:0098657)2.25233417
163activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.24363009
164positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23975098
165* cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.21916354
166extracellular matrix disassembly (GO:0022617)2.21565855
167cell volume homeostasis (GO:0006884)2.20321604
168* positive regulation of p38MAPK cascade (GO:1900745)2.20072108
169multicellular organismal catabolic process (GO:0044243)2.19414905
170heart valve formation (GO:0003188)2.19048220
171endothelial cell morphogenesis (GO:0001886)2.18386182
172endocytic recycling (GO:0032456)2.18331124
173fructose metabolic process (GO:0006000)2.18111370
174multicellular organismal metabolic process (GO:0044236)2.17678861
175response to epidermal growth factor (GO:0070849)2.17652850
176metanephric mesenchyme development (GO:0072075)2.17223940
177Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.16513540
178myelin maintenance (GO:0043217)2.16504063
179mesenchyme morphogenesis (GO:0072132)2.14050025
180cellular response to prostaglandin stimulus (GO:0071379)2.13463621
181regulation of catenin import into nucleus (GO:0035412)2.12209955
182heart valve morphogenesis (GO:0003179)2.11092411
183regulation of early endosome to late endosome transport (GO:2000641)2.10688168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.41774847
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57132840
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.02903941
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.57472276
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.56026261
6CLOCK_20551151_ChIP-Seq_293T_Human3.04508037
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93637837
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.65329932
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.57889266
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40496078
11* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36716154
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.35041868
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.05792045
14EP300_21415370_ChIP-Seq_HL-1_Mouse1.96037229
15RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95716796
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.95067229
17* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85598198
18* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83214207
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77987687
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.76255971
21TBX20_22080862_ChIP-Seq_HEART_Mouse1.76255971
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.73058677
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67037884
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.66837879
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.63848696
26GATA1_22025678_ChIP-Seq_K562_Human1.58538538
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56872437
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53569548
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52761940
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49220753
31ZNF263_19887448_ChIP-Seq_K562_Human1.47734530
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40802497
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40707496
34* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39774164
35* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37221450
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37145502
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37104974
38* FOXO3_23340844_ChIP-Seq_DLD1_Human1.34750056
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34310961
40* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32051577
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.31805814
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31793359
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29728702
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27084940
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.24243054
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23710223
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23623370
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23419485
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22779630
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22289293
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22289293
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22005286
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21230813
54* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19820853
55* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19086673
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18320113
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18201129
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18201129
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17069719
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16524723
61* UBF1/2_26484160_Chip-Seq_HMECs_Human1.15942338
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14623734
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14607905
64* KDM2B_26808549_Chip-Seq_K562_Human1.14423686
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13203797
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12800044
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12188592
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12094597
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11336606
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.09489692
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.09220190
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08750696
73* LXR_22292898_ChIP-Seq_THP-1_Human1.08333118
74* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08066140
75* RACK7_27058665_Chip-Seq_MCF-7_Human1.07884803
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07382366
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06735390
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06090848
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.04995494
80AHR_22903824_ChIP-Seq_MCF-7_Human1.04704646
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03836976
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03434990
83* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03305639
84GATA1_19941826_ChIP-Seq_K562_Human1.02311039
85CJUN_26792858_Chip-Seq_BT549_Human1.02298146
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02100213
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99182101
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.99104814
89* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99042590
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98813529
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98509628
92ISL1_27105846_Chip-Seq_CPCs_Mouse0.97651548
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96375726
94KLF5_25053715_ChIP-Seq_YYC3_Human0.95908555
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.95639314
96* RNF2_27304074_Chip-Seq_ESCs_Mouse0.95357373
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.94292076
98* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93347357
99* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93347357
100SOX2_20726797_ChIP-Seq_SW620_Human0.93053396
101TP53_22127205_ChIP-Seq_IMR90_Human0.91960650
102GATA4_25053715_ChIP-Seq_YYC3_Human0.91567609
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89806985
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87706066
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.87060846
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.86119082
107* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85670886
108* KDM2B_26808549_Chip-Seq_DND41_Human0.85564327
109DROSHA_22980978_ChIP-Seq_HELA_Human0.85006676
110CREB1_26743006_Chip-Seq_LNCaP_Human0.84328060
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83276404
112RXR_22108803_ChIP-Seq_LS180_Human0.83013024
113* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82079247
114BCAT_22108803_ChIP-Seq_LS180_Human0.81904860
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.81294090
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.80596582
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80187470
118GATA2_19941826_ChIP-Seq_K562_Human0.79661433
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79386597
120GATA6_25053715_ChIP-Seq_YYC3_Human0.78201615
121* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77671039
122* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77306374
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77226360
124* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77203418
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76114131
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.76050780
127* ATF3_27146783_Chip-Seq_COLON_Human0.75900707
128TP53_16413492_ChIP-PET_HCT116_Human0.75860017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.18915559
2MP0005360_urolithiasis3.32266430
3MP0005365_abnormal_bile_salt3.24637635
4MP0002837_dystrophic_cardiac_calcinosis3.12818044
5MP0005085_abnormal_gallbladder_physiolo2.91825135
6MP0003252_abnormal_bile_duct2.69017645
7MP0009379_abnormal_foot_pigmentation2.53640180
8MP0003705_abnormal_hypodermis_morpholog2.52324746
9MP0005257_abnormal_intraocular_pressure2.52165625
10MP0005076_abnormal_cell_differentiation2.46471204
11MP0004130_abnormal_muscle_cell2.43520377
12* MP0004084_abnormal_cardiac_muscle2.27198735
13MP0010368_abnormal_lymphatic_system2.23207445
14MP0008875_abnormal_xenobiotic_pharmacok2.16631783
15MP0009780_abnormal_chondrocyte_physiolo2.14803893
16MP0010329_abnormal_lipoprotein_level2.14643435
17MP0000579_abnormal_nail_morphology2.12998633
18MP0005409_darkened_coat_color2.10874523
19MP0003123_paternal_imprinting2.06732651
20MP0005670_abnormal_white_adipose2.01132168
21MP0003195_calcinosis1.95319395
22MP0005503_abnormal_tendon_morphology1.93240452
23MP0005666_abnormal_adipose_tissue1.92184457
24MP0004272_abnormal_basement_membrane1.89814143
25MP0004858_abnormal_nervous_system1.89590334
26MP0000751_myopathy1.85398446
27MP0002060_abnormal_skin_morphology1.84162353
28MP0004043_abnormal_pH_regulation1.82252730
29MP0005332_abnormal_amino_acid1.80835050
30MP0002877_abnormal_melanocyte_morpholog1.80320382
31MP0005083_abnormal_biliary_tract1.80314840
32MP0002138_abnormal_hepatobiliary_system1.78028070
33MP0009840_abnormal_foam_cell1.77999407
34* MP0004036_abnormal_muscle_relaxation1.76085731
35MP0008438_abnormal_cutaneous_collagen1.72803402
36MP0002909_abnormal_adrenal_gland1.72450255
37MP0004185_abnormal_adipocyte_glucose1.72199111
38MP0005023_abnormal_wound_healing1.68263220
39MP0003283_abnormal_digestive_organ1.68155623
40MP0003646_muscle_fatigue1.66399727
41MP0002118_abnormal_lipid_homeostasis1.62652913
42MP0000762_abnormal_tongue_morphology1.62029368
43MP0006138_congestive_heart_failure1.61169909
44MP0005330_cardiomyopathy1.59325477
45MP0004215_abnormal_myocardial_fiber1.57655758
46MP0005375_adipose_tissue_phenotype1.56246672
47MP0003300_gastrointestinal_ulcer1.54910640
48MP0009643_abnormal_urine_homeostasis1.53348902
49MP0000013_abnormal_adipose_tissue1.52243258
50* MP0004087_abnormal_muscle_fiber1.48829838
51MP0008961_abnormal_basal_metabolism1.47056001
52MP0003566_abnormal_cell_adhesion1.46915269
53MP0001849_ear_inflammation1.46560345
54MP0001666_abnormal_nutrient_absorption1.46451502
55MP0003453_abnormal_keratinocyte_physiol1.44023947
56MP0000383_abnormal_hair_follicle1.42314693
57MP0010678_abnormal_skin_adnexa1.40523155
58* MP0010630_abnormal_cardiac_muscle1.37147556
59* MP0002972_abnormal_cardiac_muscle1.35063777
60MP0000534_abnormal_ureter_morphology1.34793921
61MP0000003_abnormal_adipose_tissue1.34635598
62MP0003191_abnormal_cellular_cholesterol1.33288336
63MP0005623_abnormal_meninges_morphology1.32318225
64MP0000609_abnormal_liver_physiology1.31027041
65* MP0005385_cardiovascular_system_phenoty1.29731730
66* MP0001544_abnormal_cardiovascular_syste1.29731730
67MP0005167_abnormal_blood-brain_barrier1.27855185
68MP0003115_abnormal_respiratory_system1.27189196
69MP0004782_abnormal_surfactant_physiolog1.26730806
70MP0003942_abnormal_urinary_system1.26063554
71MP0000733_abnormal_muscle_development1.25432686
72MP0002078_abnormal_glucose_homeostasis1.24790787
73MP0010352_gastrointestinal_tract_polyps1.24057566
74MP0005319_abnormal_enzyme/_coenzyme1.23718231
75MP0000467_abnormal_esophagus_morphology1.21788638
76* MP0005620_abnormal_muscle_contractility1.20600848
77MP0000749_muscle_degeneration1.20472648
78MP0000750_abnormal_muscle_regeneration1.19606823
79MP0002971_abnormal_brown_adipose1.18289888
80MP0002896_abnormal_bone_mineralization1.15935567
81MP0003329_amyloid_beta_deposits1.15669393
82MP0001502_abnormal_circadian_rhythm1.15117329
83* MP0008775_abnormal_heart_ventricle1.15011064
84MP0000230_abnormal_systemic_arterial1.14144867
85MP0009384_cardiac_valve_regurgitation1.13906262
86MP0000537_abnormal_urethra_morphology1.12958403
87MP0003045_fibrosis1.12724346
88MP0004264_abnormal_extraembryonic_tissu1.11582694
89MP0005451_abnormal_body_composition1.10440301
90MP0003279_aneurysm1.09771868
91MP0001944_abnormal_pancreas_morphology1.09695922
92MP0001756_abnormal_urination1.07658338
93MP0001958_emphysema1.07234695
94MP0002249_abnormal_larynx_morphology1.06792818
95* MP0002269_muscular_atrophy1.03604489
96MP0000566_synostosis1.03318131
97MP0003868_abnormal_feces_composition1.01812570
98MP0005275_abnormal_skin_tensile1.00690211
99MP0001661_extended_life_span1.00158024
100MP0004233_abnormal_muscle_weight1.00027739
101MP0002234_abnormal_pharynx_morphology0.98060641
102MP0004510_myositis0.95463477
103MP0005058_abnormal_lysosome_morphology0.94252759
104MP0003806_abnormal_nucleotide_metabolis0.92969053
105MP0005334_abnormal_fat_pad0.92956632
106MP0002168_other_aberrant_phenotype0.92000494
107MP0005508_abnormal_skeleton_morphology0.91807219
108MP0005187_abnormal_penis_morphology0.90704287
109MP0002295_abnormal_pulmonary_circulatio0.90612646
110MP0002697_abnormal_eye_size0.90332287
111* MP0001879_abnormal_lymphatic_vessel0.90070079
112MP0004484_altered_response_of0.89097533
113MP0003385_abnormal_body_wall0.88964742
114MP0000462_abnormal_digestive_system0.87635189
115MP0005197_abnormal_uvea_morphology0.86965821
116MP0002089_abnormal_postnatal_growth/wei0.86684226
117MP0001915_intracranial_hemorrhage0.86083592
118MP0001765_abnormal_ion_homeostasis0.86036787
119MP0000759_abnormal_skeletal_muscle0.85063847
120* MP0004085_abnormal_heartbeat0.84699930
121MP0003122_maternal_imprinting0.84500531
122* MP0001614_abnormal_blood_vessel0.84205687
123* MP0002925_abnormal_cardiovascular_devel0.84184866
124MP0005584_abnormal_enzyme/coenzyme_acti0.83644794
125MP0005220_abnormal_exocrine_pancreas0.83131950
126MP0002822_catalepsy0.83058888
127MP0003828_pulmonary_edema0.82921329
128MP0001299_abnormal_eye_distance/0.82225056
129* MP0002128_abnormal_blood_circulation0.81328031
130MP0002693_abnormal_pancreas_physiology0.81306147
131MP0010234_abnormal_vibrissa_follicle0.79146695
132MP0002136_abnormal_kidney_physiology0.77260471
133* MP0003634_abnormal_glial_cell0.76980625
134* MP0002106_abnormal_muscle_physiology0.75127251
135MP0002928_abnormal_bile_duct0.74855634
136* MP0000678_abnormal_parathyroid_gland0.73578642
137MP0004019_abnormal_vitamin_homeostasis0.72418021
138MP0000767_abnormal_smooth_muscle0.72320315
139MP0002108_abnormal_muscle_morphology0.71696315
140* MP0000747_muscle_weakness0.71609885
141MP0005595_abnormal_vascular_smooth0.69617479
142MP0004859_abnormal_synaptic_plasticity0.68913344
143MP0005164_abnormal_response_to0.68553482
144* MP0003935_abnormal_craniofacial_develop0.68340182
145MP0003953_abnormal_hormone_level0.67833327
146* MP0005369_muscle_phenotype0.67798689
147* MP0000266_abnormal_heart_morphology0.67565172
148MP0002098_abnormal_vibrissa_morphology0.67371419
149MP0005165_increased_susceptibility_to0.67370663
150MP0003091_abnormal_cell_migration0.66420454
151MP0005535_abnormal_body_temperature0.66271747
152MP0003690_abnormal_glial_cell0.65606209
153MP0003879_abnormal_hair_cell0.64272289
154MP0001177_atelectasis0.63958074
155MP0002092_abnormal_eye_morphology0.61783342
156* MP0002116_abnormal_craniofacial_bone0.61292930
157MP0010771_integument_phenotype0.61089968
158* MP0000432_abnormal_head_morphology0.60616383

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.99786094
2Hypoglycemic coma (HP:0001325)4.49200268
3Deep venous thrombosis (HP:0002625)4.21369007
4Ketoacidosis (HP:0001993)4.06282099
5Premature rupture of membranes (HP:0001788)3.98434009
6Atrophic scars (HP:0001075)3.74321630
7Hyperinsulinemic hypoglycemia (HP:0000825)3.70012457
8Neonatal short-limb short stature (HP:0008921)3.55276189
9Ketosis (HP:0001946)3.50440236
10Arterial tortuosity (HP:0005116)3.46409753
11Xanthomatosis (HP:0000991)3.44596717
12Right ventricular cardiomyopathy (HP:0011663)3.34778533
13Vascular tortuosity (HP:0004948)3.28649261
14Myoglobinuria (HP:0002913)3.26846890
15Hypoglycemic seizures (HP:0002173)3.20539636
16Sudden death (HP:0001699)3.17316068
17Intrahepatic cholestasis (HP:0001406)3.17150556
18Focal segmental glomerulosclerosis (HP:0000097)3.15835970
19Hyperglycemia (HP:0003074)2.97933622
20Bladder diverticulum (HP:0000015)2.95575470
21Shallow orbits (HP:0000586)2.86371804
22Aortic dissection (HP:0002647)2.81437268
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.81253115
24Exercise-induced muscle cramps (HP:0003710)2.81195833
25Hyperacusis (HP:0010780)2.77906905
26Lymphangioma (HP:0100764)2.76556625
27Hypoalphalipoproteinemia (HP:0003233)2.74893672
28Polycythemia (HP:0001901)2.74570338
29Mesangial abnormality (HP:0001966)2.73074465
30Nuclear cataract (HP:0100018)2.72111507
31Skin nodule (HP:0200036)2.71248665
32Hyporeflexia of lower limbs (HP:0002600)2.70508731
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70318952
34Vertebral arch anomaly (HP:0008438)2.69457632
35Ventricular tachycardia (HP:0004756)2.68877863
36Hyperglycinuria (HP:0003108)2.68825392
37Glomerulosclerosis (HP:0000096)2.64697487
38Broad metatarsal (HP:0001783)2.61569236
39Hyperlipoproteinemia (HP:0010980)2.61218163
40Late onset (HP:0003584)2.59641099
41Obstructive sleep apnea (HP:0002870)2.59501668
42Fragile skin (HP:0001030)2.57752057
43Increased connective tissue (HP:0009025)2.56243266
44Abnormality of the common coagulation pathway (HP:0010990)2.53746739
45Soft skin (HP:0000977)2.52193847
46Wormian bones (HP:0002645)2.51600127
47Biconcave vertebral bodies (HP:0004586)2.50549650
48Muscle fiber splitting (HP:0003555)2.48168777
49Epidermoid cyst (HP:0200040)2.48048361
50Exercise-induced myalgia (HP:0003738)2.47989223
51Abnormality of dentin (HP:0010299)2.47393996
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46962701
53Asymmetric septal hypertrophy (HP:0001670)2.46828450
54Hyperammonemia (HP:0001987)2.45875449
55Complement deficiency (HP:0004431)2.44553545
56Gout (HP:0001997)2.44458998
57Insulin-resistant diabetes mellitus (HP:0000831)2.40114411
58Abnormality of the intrinsic pathway (HP:0010989)2.38686077
59Aneurysm (HP:0002617)2.38575183
60Neurofibrillary tangles (HP:0002185)2.35831711
61Abnormality of glycine metabolism (HP:0010895)2.34861935
62Abnormality of serine family amino acid metabolism (HP:0010894)2.34861935
63Difficulty running (HP:0009046)2.34509937
64Abnormality of proline metabolism (HP:0010907)2.31970549
65Hydroxyprolinuria (HP:0003080)2.31970549
66Mitral valve prolapse (HP:0001634)2.31467312
67Nephritis (HP:0000123)2.31051345
68Symptomatic seizures (HP:0011145)2.28849377
69Hyperkalemia (HP:0002153)2.28150091
70Abnormality of fatty-acid metabolism (HP:0004359)2.28002647
71Bronchomalacia (HP:0002780)2.27068661
72Atrioventricular block (HP:0001678)2.26856746
73Asymmetry of the thorax (HP:0001555)2.24670676
74Cerebral aneurysm (HP:0004944)2.24012986
75Visceral angiomatosis (HP:0100761)2.23901322
76Esophageal varix (HP:0002040)2.22843959
77Abnormality of purine metabolism (HP:0004352)2.22247483
78Hyperextensible skin (HP:0000974)2.22149975
79Segmental peripheral demyelination/remyelination (HP:0003481)2.21359677
80Mitral regurgitation (HP:0001653)2.20304922
81Interstitial pulmonary disease (HP:0006530)2.20063075
82Myocardial infarction (HP:0001658)2.19573051
83Turricephaly (HP:0000262)2.18037316
84Atrial fibrillation (HP:0005110)2.17825279
85Pancreatic islet-cell hyperplasia (HP:0004510)2.16553335
86Abnormality of the pancreatic islet cells (HP:0006476)2.15600955
87Abnormality of endocrine pancreas physiology (HP:0012093)2.15600955
88Syncope (HP:0001279)2.15290370
89Broad face (HP:0000283)2.15235629
90Aortic aneurysm (HP:0004942)2.12395833
91Mild short stature (HP:0003502)2.12189302
92Glomerulonephritis (HP:0000099)2.11756839
93Ulnar bowing (HP:0003031)2.11615124
94Bundle branch block (HP:0011710)2.11575918
95Hypoplastic ischia (HP:0003175)2.11400333
96Hypolipoproteinemia (HP:0010981)2.10999715
97Abnormality of complement system (HP:0005339)2.10858361
98Type 1 muscle fiber predominance (HP:0003803)2.10617600
99Hemangiomatosis (HP:0007461)2.09428490
100Advanced eruption of teeth (HP:0006288)2.06580504
101Blue sclerae (HP:0000592)2.03403059
102Ankyloglossia (HP:0010296)2.03217477
103Abnormality of the left ventricular outflow tract (HP:0011103)2.02520662
104Subaortic stenosis (HP:0001682)2.02520662
105Increased variability in muscle fiber diameter (HP:0003557)2.02031177
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01360562
107Tibial bowing (HP:0002982)2.01258962
108Abnormality of the ischium (HP:0003174)2.00357842
109Lipoatrophy (HP:0100578)1.99629712
110Cholecystitis (HP:0001082)1.99407366
111Abnormal gallbladder physiology (HP:0012438)1.99407366
112Mildly elevated creatine phosphokinase (HP:0008180)1.99203613
113Facial shape deformation (HP:0011334)1.99129385
114Potter facies (HP:0002009)1.99129385
115Hyperglycinemia (HP:0002154)1.98418919
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97825801
117Primary atrial arrhythmia (HP:0001692)1.97766996
118Hematochezia (HP:0002573)1.97652856
119Spinal rigidity (HP:0003306)1.97617787
120Natal tooth (HP:0000695)1.96793866
121Hyperactive renin-angiotensin system (HP:0000841)1.96790544
122Back pain (HP:0003418)1.96013716
123Large for gestational age (HP:0001520)1.95012400
124Heart block (HP:0012722)1.94572398
125Insulin resistance (HP:0000855)1.94097325
126Calf muscle hypertrophy (HP:0008981)1.93705396
127Overgrowth (HP:0001548)1.93666120
128Cervical subluxation (HP:0003308)1.93011324
129Aortic regurgitation (HP:0001659)1.92757143
130Wide anterior fontanel (HP:0000260)1.92085181
131Renovascular hypertension (HP:0100817)1.91082986
132Vertebral compression fractures (HP:0002953)1.90818606
133Enlarged penis (HP:0000040)1.90405612
134Abnormal atrioventricular conduction (HP:0005150)1.89587432
135Rhabdomyolysis (HP:0003201)1.89526475
136Prolonged QT interval (HP:0001657)1.88876063
137Hammertoe (HP:0001765)1.88420388
138Morphological abnormality of the middle ear (HP:0008609)1.87363318
139Ventricular arrhythmia (HP:0004308)1.87170871
140Bowel diverticulosis (HP:0005222)1.85763773
141Prolonged partial thromboplastin time (HP:0003645)1.85730101
142Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85561071
143Genu recurvatum (HP:0002816)1.85001106
144Insomnia (HP:0100785)1.84744427
145Renal duplication (HP:0000075)1.84694396
146Palpitations (HP:0001962)1.84678319
147Cerebral inclusion bodies (HP:0100314)1.84651007
148Long toe (HP:0010511)1.83732038
149Supraventricular arrhythmia (HP:0005115)1.82549739
150Thin ribs (HP:0000883)1.82148859
151Flat acetabular roof (HP:0003180)1.81331220
152Mitral stenosis (HP:0001718)1.80810860
153Dilated cardiomyopathy (HP:0001644)1.80006517
154Flat cornea (HP:0007720)1.79308777
155Hemorrhage of the eye (HP:0011885)1.79222899
156Metaphyseal cupping (HP:0003021)1.79028018
157Breech presentation (HP:0001623)1.78820202
158Supraventricular tachycardia (HP:0004755)1.78461114
159Peritonitis (HP:0002586)1.78074632
160Generalized aminoaciduria (HP:0002909)1.78004746
161Abnormality of the calf musculature (HP:0001430)1.77201107
162Axonal loss (HP:0003447)1.76451763
163Disproportionate tall stature (HP:0001519)1.74252038
164Venous abnormality (HP:0002624)1.73080358
165Distal lower limb amyotrophy (HP:0008944)1.72713859
166Abnormality of the acetabulum (HP:0003170)1.72324251
167Hypoplasia of the iris (HP:0007676)1.71836052
168Nonimmune hydrops fetalis (HP:0001790)1.68603418
169Joint laxity (HP:0001388)1.68110799
170Pterygium (HP:0001059)1.67757757
171Upper limb amyotrophy (HP:0009129)1.67621473
172Distal upper limb amyotrophy (HP:0007149)1.67621473
173Aplasia involving bones of the extremities (HP:0009825)1.66537756
174Aplasia involving bones of the upper limbs (HP:0009823)1.66537756
175Aplasia of the phalanges of the hand (HP:0009802)1.66537756
176Macroorchidism (HP:0000053)1.66496296
177Venous insufficiency (HP:0005293)1.66380665
178Thin bony cortex (HP:0002753)1.65415109
179Abnormality of skeletal muscle fiber size (HP:0012084)1.64005983
180Onion bulb formation (HP:0003383)1.63559109
181Abnormality of the calcaneus (HP:0008364)1.63460198
182Cupped ribs (HP:0000887)1.62753179
183Abnormal delivery (HP:0001787)1.62366193
184Dilatation of the ascending aorta (HP:0005111)1.61523663
185Osteoarthritis (HP:0002758)1.59942881
186Elfin facies (HP:0004428)1.59423320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.45302207
2PKN23.35942774
3SIK13.12365464
4INSRR2.93878979
5ERN12.91837875
6TTN2.46616987
7CDK122.43707963
8EEF2K2.33666401
9LATS22.29122456
10PDGFRA2.26692100
11TAOK32.24165472
12LATS12.22956247
13RIPK12.14905973
14WNK42.04844043
15TIE12.04432194
16BCKDK2.04208021
17FGFR42.00101683
18PTK61.87912154
19MOS1.57377514
20EPHB11.56008041
21FLT31.54025206
22EPHB21.53397581
23CAMK1D1.50728140
24CAMK1G1.46709819
25PHKG21.36126988
26PHKG11.36126988
27DMPK1.34460462
28MAP3K131.31441208
29FRK1.30334197
30LMTK21.30161722
31FGFR21.29241418
32SIK21.29184796
33AKT31.26375607
34TYRO31.25450354
35TGFBR21.22745019
36MYLK1.22667322
37EPHA31.22521629
38PRKD31.19298743
39PTK21.18570157
40OBSCN1.17809023
41MAP3K71.11840908
42PAK31.11285034
43RET1.09812849
44PIK3CA1.07144165
45FER1.06865523
46MAP3K21.06535136
47MET1.04393634
48PRKD11.04019003
49MST1R1.01164939
50FGFR31.00819688
51TNIK1.00427736
52PDK41.00044323
53PDK31.00044323
54PRKAA20.97811011
55BMX0.96573398
56PDGFRB0.94562909
57JAK10.92928919
58PRKCH0.92334236
59DDR20.92234082
60MAP3K60.90116024
61MAPK150.87502405
62PAK40.86397625
63HIPK20.85520213
64MAP3K10.84901889
65MTOR0.84728144
66EPHA20.81858806
67MAP3K90.81254410
68PRKAA10.81096224
69MAP3K30.77891443
70PRPF4B0.77766439
71MAP3K100.77471313
72NEK90.77385928
73GSK3A0.75301670
74DYRK1B0.73861942
75MARK10.73758973
76MAPKAPK30.73448377
77CDC42BPA0.73099378
78JAK20.72916041
79NTRK10.71726873
80IRAK30.71515881
81MAP2K30.70157440
82RPS6KA20.69859641
83FGFR10.69640542
84LRRK20.68065810
85NTRK30.67689976
86SGK2230.66639256
87SGK4940.66639256
88SGK30.66546458
89ROCK20.66212228
90PKN10.64897632
91ROCK10.63283803
92PDPK10.62769907
93SMG10.60807736
94BRD40.60611102
95WNK10.60210552
96NEK20.58895954
97KSR10.58777599
98ICK0.57464270
99NEK10.56765042
100PRKD20.52569561
101PAK20.52312816
102STK240.52213176
103PIK3CG0.51346508
104MAP2K10.51018376
105ERBB20.50020085
106KDR0.48180654
107MAPK110.47500766
108MAPK100.47307367
109KSR20.46934827
110PRKACG0.46539789
111ERBB40.45757248
112RPS6KC10.44912961
113RPS6KL10.44912961
114MAPK70.44889691
115STK38L0.44301898
116MAP2K60.43319592
117PDK20.43150642
118ARAF0.43064014
119NTRK20.42744799
120CDK60.42477414
121DAPK20.42048000
122ILK0.41235143
123IGF1R0.40729951
124STK380.40364508
125CAMK40.39606244
126CAMK2G0.39026097
127STK30.38324742
128TRPM70.36202774
129YES10.35839320
130MARK20.34705597
131CAMK2D0.33981523
132STK390.31969861
133MAPK120.31787081
134PRKCE0.30897203

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.74765565
2Nitrogen metabolism_Homo sapiens_hsa009102.62225286
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42163983
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39891419
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.31510440
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30324719
7Propanoate metabolism_Homo sapiens_hsa006402.25483025
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.24428392
9Fatty acid metabolism_Homo sapiens_hsa012122.18596697
10Tryptophan metabolism_Homo sapiens_hsa003802.18545704
11Arginine biosynthesis_Homo sapiens_hsa002202.08037830
12PPAR signaling pathway_Homo sapiens_hsa033202.05068353
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02868439
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94142397
15Butanoate metabolism_Homo sapiens_hsa006501.79099553
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78165658
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68401034
18Complement and coagulation cascades_Homo sapiens_hsa046101.60731458
19Notch signaling pathway_Homo sapiens_hsa043301.55413390
20Bile secretion_Homo sapiens_hsa049761.52297569
21Starch and sucrose metabolism_Homo sapiens_hsa005001.44696451
22Lysine degradation_Homo sapiens_hsa003101.42482519
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33883019
24Other glycan degradation_Homo sapiens_hsa005111.33384528
25Insulin resistance_Homo sapiens_hsa049311.32768429
26* Renal cell carcinoma_Homo sapiens_hsa052111.32635219
27Fat digestion and absorption_Homo sapiens_hsa049751.32180240
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31360199
29* Bladder cancer_Homo sapiens_hsa052191.29577691
30Carbon metabolism_Homo sapiens_hsa012001.28550462
31Chronic myeloid leukemia_Homo sapiens_hsa052201.27448837
32Peroxisome_Homo sapiens_hsa041461.27410082
33Dilated cardiomyopathy_Homo sapiens_hsa054141.27332716
34Pyruvate metabolism_Homo sapiens_hsa006201.26039613
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.24017260
36Endometrial cancer_Homo sapiens_hsa052131.22529617
37Caffeine metabolism_Homo sapiens_hsa002321.20817909
38* HIF-1 signaling pathway_Homo sapiens_hsa040661.20272369
39Sulfur metabolism_Homo sapiens_hsa009201.19120610
40ErbB signaling pathway_Homo sapiens_hsa040121.17309878
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16608655
42beta-Alanine metabolism_Homo sapiens_hsa004101.15970529
43Selenocompound metabolism_Homo sapiens_hsa004501.15741406
44ECM-receptor interaction_Homo sapiens_hsa045121.14909772
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14478149
46Fatty acid biosynthesis_Homo sapiens_hsa000611.11906049
47Type II diabetes mellitus_Homo sapiens_hsa049301.10795642
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.10365387
49* MicroRNAs in cancer_Homo sapiens_hsa052061.09569051
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07610669
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04586079
52ABC transporters_Homo sapiens_hsa020101.04561682
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04062749
54GnRH signaling pathway_Homo sapiens_hsa049120.99070917
55Glioma_Homo sapiens_hsa052140.98762587
56Non-small cell lung cancer_Homo sapiens_hsa052230.98368482
57Tyrosine metabolism_Homo sapiens_hsa003500.97681610
58Estrogen signaling pathway_Homo sapiens_hsa049150.97073205
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96423523
60* Pancreatic cancer_Homo sapiens_hsa052120.95165490
61Glucagon signaling pathway_Homo sapiens_hsa049220.94930714
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94366663
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93829276
64Phenylalanine metabolism_Homo sapiens_hsa003600.90978721
65Prostate cancer_Homo sapiens_hsa052150.88476322
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86843410
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.86192898
68Choline metabolism in cancer_Homo sapiens_hsa052310.85493804
69* Focal adhesion_Homo sapiens_hsa045100.84390871
70Protein digestion and absorption_Homo sapiens_hsa049740.84132862
71Chemical carcinogenesis_Homo sapiens_hsa052040.83577305
72AMPK signaling pathway_Homo sapiens_hsa041520.82770421
73Glycerolipid metabolism_Homo sapiens_hsa005610.81994568
74Thyroid cancer_Homo sapiens_hsa052160.79870969
75* VEGF signaling pathway_Homo sapiens_hsa043700.78838791
76Histidine metabolism_Homo sapiens_hsa003400.78000099
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77786788
78Insulin signaling pathway_Homo sapiens_hsa049100.77233884
79* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75987441
80Biosynthesis of amino acids_Homo sapiens_hsa012300.75164019
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74961192
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.74671516
83Prolactin signaling pathway_Homo sapiens_hsa049170.73340283
84FoxO signaling pathway_Homo sapiens_hsa040680.73043564
85Tight junction_Homo sapiens_hsa045300.72767420
86Axon guidance_Homo sapiens_hsa043600.71567041
87Insulin secretion_Homo sapiens_hsa049110.71426902
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.71400715
89Fatty acid elongation_Homo sapiens_hsa000620.70677317
90Pentose phosphate pathway_Homo sapiens_hsa000300.70387688
91Amoebiasis_Homo sapiens_hsa051460.69809627
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69018845
93Thyroid hormone synthesis_Homo sapiens_hsa049180.68926647
94Staphylococcus aureus infection_Homo sapiens_hsa051500.68876494
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.66889228
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65818723
97Acute myeloid leukemia_Homo sapiens_hsa052210.65519935
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64998815
99Arginine and proline metabolism_Homo sapiens_hsa003300.62877648
100Melanoma_Homo sapiens_hsa052180.62668163
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62038670
102Galactose metabolism_Homo sapiens_hsa000520.61699460
103Gap junction_Homo sapiens_hsa045400.61423275
104Retinol metabolism_Homo sapiens_hsa008300.59656770
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59556432
106* Pathways in cancer_Homo sapiens_hsa052000.59366950
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58368532
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57678525
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56569221
110Long-term potentiation_Homo sapiens_hsa047200.55771211
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55606299
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53028871
113Adherens junction_Homo sapiens_hsa045200.52737323
114* Rap1 signaling pathway_Homo sapiens_hsa040150.52526926
115Hippo signaling pathway_Homo sapiens_hsa043900.51984747
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50733611
117Pertussis_Homo sapiens_hsa051330.50071891
118TNF signaling pathway_Homo sapiens_hsa046680.48892630
119Hepatitis C_Homo sapiens_hsa051600.48403631
120Mineral absorption_Homo sapiens_hsa049780.47777139
121Vitamin digestion and absorption_Homo sapiens_hsa049770.46967481
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45874135
123Dorso-ventral axis formation_Homo sapiens_hsa043200.45697987
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45585762
125Small cell lung cancer_Homo sapiens_hsa052220.45480170
126TGF-beta signaling pathway_Homo sapiens_hsa043500.44685212
127* Proteoglycans in cancer_Homo sapiens_hsa052050.44414877
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43607450
129Ovarian steroidogenesis_Homo sapiens_hsa049130.42191842
130Circadian rhythm_Homo sapiens_hsa047100.41740898
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.40022050
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37067591
133Renin secretion_Homo sapiens_hsa049240.35733246
134Renin-angiotensin system_Homo sapiens_hsa046140.34798604
135Fructose and mannose metabolism_Homo sapiens_hsa000510.34568985
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33809483
137Prion diseases_Homo sapiens_hsa050200.33643651
138Pancreatic secretion_Homo sapiens_hsa049720.33615251
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.33146032
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.31222380
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30454805
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30203715
143* mTOR signaling pathway_Homo sapiens_hsa041500.28657330
144Lysosome_Homo sapiens_hsa041420.28327773
145* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24961782

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