VEGFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.58016005
2sarcomere organization (GO:0045214)7.57227242
3tricarboxylic acid cycle (GO:0006099)6.79588207
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.76927900
5myofibril assembly (GO:0030239)6.58848693
6negative regulation of potassium ion transmembrane transport (GO:1901380)6.46883170
7* cardiac muscle contraction (GO:0060048)5.89054713
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.87736356
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.84562809
10muscle filament sliding (GO:0030049)5.74773647
11actin-myosin filament sliding (GO:0033275)5.74773647
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.70106664
13plasma membrane repair (GO:0001778)5.69028040
14regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.54749084
15cardiac muscle cell development (GO:0055013)5.46601242
16regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.34723905
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.25158365
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.21414744
19carnitine shuttle (GO:0006853)5.16152836
20cardiac cell development (GO:0055006)5.12394442
21regulation of actin filament-based movement (GO:1903115)5.10203528
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.92721055
23ATP synthesis coupled proton transport (GO:0015986)4.90211414
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90211414
25respiratory electron transport chain (GO:0022904)4.88579355
26regulation of acyl-CoA biosynthetic process (GO:0050812)4.88262341
27ventricular cardiac muscle cell action potential (GO:0086005)4.88123516
28adult heart development (GO:0007512)4.86008042
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.83283751
30regulation of relaxation of muscle (GO:1901077)4.79947032
31regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.76061473
32actomyosin structure organization (GO:0031032)4.75574695
33electron transport chain (GO:0022900)4.74956852
34oxidative phosphorylation (GO:0006119)4.69180269
35cardiac muscle tissue morphogenesis (GO:0055008)4.67313505
36regulation of skeletal muscle contraction (GO:0014819)4.66107196
37heart trabecula formation (GO:0060347)4.64886905
38actin-mediated cell contraction (GO:0070252)4.59830360
39regulation of coenzyme metabolic process (GO:0051196)4.59172949
40regulation of cofactor metabolic process (GO:0051193)4.59172949
41ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.51826791
42NADH metabolic process (GO:0006734)4.50128706
43* striated muscle contraction (GO:0006941)4.48739832
44sarcoplasmic reticulum calcium ion transport (GO:0070296)4.48208698
45regulation of membrane repolarization (GO:0060306)4.47596875
46fatty acid transmembrane transport (GO:1902001)4.44296949
47cardiac muscle hypertrophy (GO:0003300)4.41873480
48virion attachment to host cell (GO:0019062)4.39485677
49adhesion of symbiont to host cell (GO:0044650)4.39485677
50regulation of cell communication by electrical coupling (GO:0010649)4.34214757
51regulation of the force of heart contraction (GO:0002026)4.33124735
52cell communication involved in cardiac conduction (GO:0086065)4.31037911
53cell communication by electrical coupling (GO:0010644)4.30290229
54bundle of His cell to Purkinje myocyte communication (GO:0086069)4.28460829
55adhesion of symbiont to host (GO:0044406)4.20350902
56striated muscle hypertrophy (GO:0014897)4.19552208
57regulation of striated muscle contraction (GO:0006942)4.18028870
58muscle tissue morphogenesis (GO:0060415)4.17670792
59heart contraction (GO:0060047)4.16128171
60heart process (GO:0003015)4.16128171
61low-density lipoprotein particle clearance (GO:0034383)4.04483667
62regulation of sequestering of triglyceride (GO:0010889)4.03090221
63regulation of sarcomere organization (GO:0060297)4.02653946
642-oxoglutarate metabolic process (GO:0006103)3.94563652
65regulation of fatty acid oxidation (GO:0046320)3.77471854
66carnitine transmembrane transport (GO:1902603)3.74957726
67regulation of early endosome to late endosome transport (GO:2000641)3.74792178
68muscle hypertrophy (GO:0014896)3.68009327
69barbed-end actin filament capping (GO:0051016)3.62941294
70succinate metabolic process (GO:0006105)3.62180542
71negative regulation of potassium ion transport (GO:0043267)3.61080661
72cardiac muscle cell action potential involved in contraction (GO:0086002)3.60708728
73regulation of heart rate (GO:0002027)3.57149399
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.55732223
75regulation of sulfur metabolic process (GO:0042762)3.55166731
76activation of MAPKKK activity (GO:0000185)3.55045782
77regulation of cardiac muscle cell contraction (GO:0086004)3.54416853
78cardiac muscle cell action potential (GO:0086001)3.52734945
79regulation of cardiac muscle contraction (GO:0055117)3.51127239
80oxaloacetate metabolic process (GO:0006107)3.50440938
81negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.47273796
82cell migration involved in heart development (GO:0060973)3.46634226
83carnitine transport (GO:0015879)3.45664628
84amino-acid betaine transport (GO:0015838)3.45664628
85creatine metabolic process (GO:0006600)3.42805156
86actin filament-based movement (GO:0030048)3.40010455
87regulation of heart contraction (GO:0008016)3.37733298
88negative regulation of striated muscle cell apoptotic process (GO:0010664)3.36769132
89response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.36426017
90fatty acid beta-oxidation (GO:0006635)3.35446330
91aspartate family amino acid catabolic process (GO:0009068)3.31672234
92ATP biosynthetic process (GO:0006754)3.29753196
93tricarboxylic acid metabolic process (GO:0072350)3.28999946
94regulation of ATP catabolic process (GO:1903289)3.28731792
95regulation of ATPase activity (GO:0043462)3.28731792
96negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26480954
97oxygen transport (GO:0015671)3.26242236
98cardiac conduction (GO:0061337)3.24701903
99regulation of calcium ion transmembrane transporter activity (GO:1901019)3.23316554
100regulation of calcium ion transmembrane transport (GO:1903169)3.23316554
101cardiac muscle adaptation (GO:0014887)3.21741270
102cardiac muscle hypertrophy in response to stress (GO:0014898)3.21741270
103muscle hypertrophy in response to stress (GO:0003299)3.21741270
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21206897
105lysine metabolic process (GO:0006553)3.19882234
106lysine catabolic process (GO:0006554)3.19882234
107relaxation of cardiac muscle (GO:0055119)3.19881104
108protein heterotrimerization (GO:0070208)3.17340211
109keratan sulfate catabolic process (GO:0042340)3.17195095
110regulation of heart rate by cardiac conduction (GO:0086091)3.17077699
111striated muscle cell development (GO:0055002)3.13973500
112regulation of cholesterol storage (GO:0010885)3.10754336
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07767651
114response to dietary excess (GO:0002021)3.00850562
115stress fiber assembly (GO:0043149)2.90556989
116endothelial cell chemotaxis (GO:0035767)2.90499551
117regulation of extracellular matrix disassembly (GO:0010715)2.90042079
118triglyceride catabolic process (GO:0019433)2.86205785
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.84999458
120astrocyte differentiation (GO:0048708)2.74889423
121positive regulation of protein dephosphorylation (GO:0035307)2.73900286
122neutral lipid catabolic process (GO:0046461)2.71441911
123acylglycerol catabolic process (GO:0046464)2.71441911
124apoptotic cell clearance (GO:0043277)2.69554719
125positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.66941574
126vascular endothelial growth factor signaling pathway (GO:0038084)2.66129703
127cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.65329391
128positive regulation of receptor recycling (GO:0001921)2.62734813
129regulation of glycogen (starch) synthase activity (GO:2000465)2.62405117
130venous blood vessel morphogenesis (GO:0048845)2.53384652
131extracellular fibril organization (GO:0043206)2.51935308
132chondroitin sulfate catabolic process (GO:0030207)2.51066994
133cellular response to epinephrine stimulus (GO:0071872)2.44787422
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.41499315
135lipid storage (GO:0019915)2.40297056
136endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.39293574
137cAMP biosynthetic process (GO:0006171)2.38339544
138basement membrane organization (GO:0071711)2.37190357
139protein retention in ER lumen (GO:0006621)2.37186567
140mannose metabolic process (GO:0006013)2.35390120
141regulation of membrane protein ectodomain proteolysis (GO:0051043)2.35283844
142tooth mineralization (GO:0034505)2.33409289
143positive regulation of lipid storage (GO:0010884)2.32824463
144negative regulation of erythrocyte differentiation (GO:0045647)2.32593972
145response to parathyroid hormone (GO:0071107)2.30707293
146regulation of integrin-mediated signaling pathway (GO:2001044)2.29220993
147extracellular matrix assembly (GO:0085029)2.29175424
148positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.28878669
149UV protection (GO:0009650)2.28495201
150cellular response to monoamine stimulus (GO:0071868)2.27617775
151cellular response to catecholamine stimulus (GO:0071870)2.27617775
152protein localization to endosome (GO:0036010)2.27435091
153amino sugar catabolic process (GO:0046348)2.27396533
154response to acidic pH (GO:0010447)2.26611269
155glial cell migration (GO:0008347)2.26034909
156potassium ion export (GO:0071435)2.24737763
157glycerolipid catabolic process (GO:0046503)2.24456884
158activation of protein kinase A activity (GO:0034199)2.22403599
159fibril organization (GO:0097435)2.20773113
160cellular response to nutrient (GO:0031670)2.19495555
161* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.18662527
162negative regulation of smooth muscle cell proliferation (GO:0048662)2.17761219
163adenosine receptor signaling pathway (GO:0001973)2.16058948
164pattern specification involved in kidney development (GO:0061004)2.15992824
165skeletal muscle organ development (GO:0060538)2.15873557
166negative regulation of granulocyte differentiation (GO:0030853)2.15806721
167cortical actin cytoskeleton organization (GO:0030866)2.15074989
168protein maturation by protein folding (GO:0022417)2.14175308
169fatty acid homeostasis (GO:0055089)2.13845790
170gluconeogenesis (GO:0006094)2.13290111
171endocytic recycling (GO:0032456)2.12471544
172positive regulation of fat cell differentiation (GO:0045600)2.11468637
173calcium-mediated signaling using intracellular calcium source (GO:0035584)2.10843697
174positive regulation of extracellular matrix organization (GO:1903055)2.10557486
175macroautophagy (GO:0016236)2.09428616
176negative regulation of cell size (GO:0045792)2.09010437
177semaphorin-plexin signaling pathway (GO:0071526)2.08686597
178regulation of protein dephosphorylation (GO:0035304)2.08597257
179cell-cell junction maintenance (GO:0045217)2.08506165
180apoptotic process involved in morphogenesis (GO:0060561)2.08023048
181skin morphogenesis (GO:0043589)2.07699982
182negative regulation of adherens junction organization (GO:1903392)2.07482793
183negative regulation of focal adhesion assembly (GO:0051895)2.07482793
184negative regulation of cell junction assembly (GO:1901889)2.07482793
185response to epinephrine (GO:0071871)2.07187008
186regulation of autophagic vacuole assembly (GO:2000785)2.06969919
187adherens junction assembly (GO:0034333)2.06215812
188maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.06117183
189cellular response to thyroid hormone stimulus (GO:0097067)2.06086463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.39893075
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.84861620
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.08296469
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.07560651
5ZNF263_19887448_ChIP-Seq_K562_Human3.01459434
6TBX20_22080862_ChIP-Seq_HEART_Mouse2.96161832
7TBX20_22328084_ChIP-Seq_HEART_Mouse2.96161832
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92133701
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63642771
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45355691
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32099473
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.25737823
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25070289
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.17180175
15MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.11048463
16* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.09470912
17* LXR_22292898_ChIP-Seq_THP-1_Human2.08276889
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03475780
19EZH2_22144423_ChIP-Seq_EOC_Human1.98323443
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94176058
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93365454
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92860107
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84236719
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80366712
25GATA4_21415370_ChIP-Seq_HL-1_Mouse1.76975609
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70449948
27* KDM2B_26808549_Chip-Seq_DND41_Human1.65471333
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62063029
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59203161
30CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58850624
31CLOCK_20551151_ChIP-Seq_293T_Human1.56884144
32RACK7_27058665_Chip-Seq_MCF-7_Human1.48761044
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48643051
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47962170
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46843423
36* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46642430
37CTCF_27219007_Chip-Seq_Bcells_Human1.44104979
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43905524
39P68_20966046_ChIP-Seq_HELA_Human1.43716817
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40648667
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39723107
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38504980
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37903731
44KDM2B_26808549_Chip-Seq_K562_Human1.36356345
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36162132
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34500269
47NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34476020
48TCF7_22412390_ChIP-Seq_EML_Mouse1.32795174
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.32644304
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31798240
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29438169
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.29305020
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.28547173
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28375645
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27399110
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27326865
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27099040
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26346004
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25673814
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23818426
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.22994211
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22321889
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21633513
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20149809
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.20058143
66DROSHA_22980978_ChIP-Seq_HELA_Human1.19563750
67TP63_22573176_ChIP-Seq_HFKS_Human1.19241351
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.18433634
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17446279
70CREB1_26743006_Chip-Seq_LNCaP_Human1.17092089
71ATF3_27146783_Chip-Seq_COLON_Human1.17078474
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15700375
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15037624
74VDR_21846776_ChIP-Seq_THP-1_Human1.14367755
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14073390
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.13578110
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12864656
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12296703
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.11959255
80STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11952012
81* SA1_27219007_Chip-Seq_Bcells_Human1.11526958
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11239118
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.10831755
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10591813
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07937718
86SMC4_20622854_ChIP-Seq_HELA_Human1.07892548
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07519217
88MYC_22102868_ChIP-Seq_BL_Human1.07310240
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06911484
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06524273
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06280723
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.05614226
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05357394
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05033697
95CTCF_21964334_Chip-Seq_Bcells_Human1.04991763
96CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04765262
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04416788
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04416788
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.04222589
100TP53_22127205_ChIP-Seq_IMR90_Human1.03747783
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03502109
102CTCF_26484167_Chip-Seq_Bcells_Mouse1.03203987
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03050391
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.02256119
105BCL6_27268052_Chip-Seq_Bcells_Human1.00893025
106VDR_24763502_ChIP-Seq_THP-1_Human1.00362813
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99692085
108SPI1_20517297_ChIP-Seq_HL60_Human0.99515004
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99511647
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98136105
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97927493
112BCOR_27268052_Chip-Seq_Bcells_Human0.97854795
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97812402
114JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97361065
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.97273027
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96715812
117PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96554758
118MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94228984
119TP53_23651856_ChIP-Seq_MEFs_Mouse0.94198857
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.93705384
121* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93207548
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92155843
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91924878
124* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91762199
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91577166
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90926031
127E2F1_20622854_ChIP-Seq_HELA_Human0.90698829
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90204056
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.89560146
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88808500
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88427503
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88190414
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.87669489
134EZH2_27304074_Chip-Seq_ESCs_Mouse0.87625159
135GATA1_19941826_ChIP-Seq_K562_Human0.87386733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.35143528
2MP0003646_muscle_fatigue5.64982705
3MP0000751_myopathy5.06976329
4MP0004084_abnormal_cardiac_muscle5.06160390
5MP0004215_abnormal_myocardial_fiber4.35137076
6MP0004036_abnormal_muscle_relaxation3.78043836
7MP0005330_cardiomyopathy3.71196587
8MP0000749_muscle_degeneration3.66443537
9MP0005058_abnormal_lysosome_morphology3.48218736
10MP0004087_abnormal_muscle_fiber3.03441101
11MP0004130_abnormal_muscle_cell3.00784731
12MP0005503_abnormal_tendon_morphology2.90699687
13MP0002972_abnormal_cardiac_muscle2.88440136
14MP0008775_abnormal_heart_ventricle2.80937248
15MP0000750_abnormal_muscle_regeneration2.77041661
16* MP0003137_abnormal_impulse_conducting2.72270914
17MP0005620_abnormal_muscle_contractility2.52231158
18MP0009840_abnormal_foam_cell2.51124602
19MP0002106_abnormal_muscle_physiology2.49060537
20MP0004145_abnormal_muscle_electrophysio2.48719116
21MP0010630_abnormal_cardiac_muscle2.48077702
22* MP0001544_abnormal_cardiovascular_syste2.44249406
23* MP0005385_cardiovascular_system_phenoty2.44249406
24MP0002269_muscular_atrophy2.35041562
25MP0004233_abnormal_muscle_weight2.33281165
26MP0001958_emphysema2.33013132
27MP0004484_altered_response_of2.32838286
28MP0006138_congestive_heart_failure2.32313069
29MP0005257_abnormal_intraocular_pressure2.20247139
30MP0003828_pulmonary_edema2.07812205
31MP0000759_abnormal_skeletal_muscle2.06580161
32MP0005369_muscle_phenotype2.04163964
33MP0006036_abnormal_mitochondrial_physio2.02908308
34MP0000747_muscle_weakness2.00611729
35MP0004085_abnormal_heartbeat1.99367783
36MP0005670_abnormal_white_adipose1.99167243
37MP0003221_abnormal_cardiomyocyte_apopto1.94211953
38MP0005666_abnormal_adipose_tissue1.86837326
39MP0003879_abnormal_hair_cell1.70910057
40MP0002332_abnormal_exercise_endurance1.59623153
41MP0003172_abnormal_lysosome_physiology1.57916450
42MP0005451_abnormal_body_composition1.52199545
43MP0004185_abnormal_adipocyte_glucose1.47920262
44MP0002127_abnormal_cardiovascular_syste1.47046879
45MP0009384_cardiac_valve_regurgitation1.46973311
46MP0003329_amyloid_beta_deposits1.44529242
47MP0005375_adipose_tissue_phenotype1.36791025
48MP0003567_abnormal_fetal_cardiomyocyte1.35838754
49MP0005508_abnormal_skeleton_morphology1.30735036
50MP0003690_abnormal_glial_cell1.29187678
51MP0005409_darkened_coat_color1.28197771
52MP0002295_abnormal_pulmonary_circulatio1.25979278
53MP0004510_myositis1.25034627
54MP0000604_amyloidosis1.23997424
55MP0003634_abnormal_glial_cell1.17471155
56MP0003191_abnormal_cellular_cholesterol1.14684425
57* MP0000266_abnormal_heart_morphology1.13286699
58MP0001542_abnormal_bone_strength1.11623862
59MP0004043_abnormal_pH_regulation1.11256560
60MP0002234_abnormal_pharynx_morphology1.10888481
61MP0002909_abnormal_adrenal_gland1.09623193
62MP0003705_abnormal_hypodermis_morpholog1.09530954
63MP0003075_altered_response_to1.09446468
64MP0000013_abnormal_adipose_tissue1.08264966
65MP0009379_abnormal_foot_pigmentation1.05653619
66MP0002896_abnormal_bone_mineralization1.02698430
67MP0006035_abnormal_mitochondrial_morpho1.02407047
68MP0000003_abnormal_adipose_tissue1.02234696
69MP0002249_abnormal_larynx_morphology1.00510655
70MP0003279_aneurysm0.98658875
71MP0003303_peritoneal_inflammation0.98249492
72MP0003453_abnormal_keratinocyte_physiol0.98200496
73MP0001502_abnormal_circadian_rhythm0.96461831
74MP0005623_abnormal_meninges_morphology0.96263762
75MP0005165_increased_susceptibility_to0.95943348
76MP0002998_abnormal_bone_remodeling0.95806979
77MP0000858_altered_metastatic_potential0.95628867
78MP0005171_absent_coat_pigmentation0.95334020
79MP0003091_abnormal_cell_migration0.93679065
80MP0002933_joint_inflammation0.92515056
81MP0002108_abnormal_muscle_morphology0.92135644
82MP0005266_abnormal_metabolism0.92111442
83MP0000681_abnormal_thyroid_gland0.90912881
84MP0002638_abnormal_pupillary_reflex0.88893775
85MP0002971_abnormal_brown_adipose0.87215410
86MP0008961_abnormal_basal_metabolism0.86847439
87MP0001849_ear_inflammation0.83231485
88MP0009780_abnormal_chondrocyte_physiolo0.81885571
89* MP0000343_altered_response_to0.80274976
90MP0005023_abnormal_wound_healing0.79709084
91MP0003950_abnormal_plasma_membrane0.78755524
92MP0000230_abnormal_systemic_arterial0.78492031
93MP0005390_skeleton_phenotype0.78365905
94MP0003011_delayed_dark_adaptation0.77119886
95MP0003186_abnormal_redox_activity0.75796662
96MP0000920_abnormal_myelination0.75741506
97MP0005379_endocrine/exocrine_gland_phen0.72156144
98MP0000678_abnormal_parathyroid_gland0.71799641
99MP0002060_abnormal_skin_morphology0.70170043
100MP0004858_abnormal_nervous_system0.68612890
101MP0002128_abnormal_blood_circulation0.68536351
102MP0005535_abnormal_body_temperature0.68486261
103MP0003283_abnormal_digestive_organ0.68402944
104MP0003300_gastrointestinal_ulcer0.67796207
105MP0002078_abnormal_glucose_homeostasis0.66408160
106MP0010368_abnormal_lymphatic_system0.65696392
107MP0008438_abnormal_cutaneous_collagen0.64786152
108MP0000733_abnormal_muscle_development0.61720007
109MP0003566_abnormal_cell_adhesion0.56154774
110MP0004272_abnormal_basement_membrane0.48948371
111MP0005334_abnormal_fat_pad0.48804169
112MP0009115_abnormal_fat_cell0.48426742
113MP0002970_abnormal_white_adipose0.48059395
114MP0002877_abnormal_melanocyte_morpholog0.47366917
115MP0005319_abnormal_enzyme/_coenzyme0.46732518
116MP0008569_lethality_at_weaning0.45202760
117MP0003948_abnormal_gas_homeostasis0.43549999
118MP0005386_behavior/neurological_phenoty0.42353401
119MP0004924_abnormal_behavior0.42353401
120MP0002822_catalepsy0.41681542
121* MP0002925_abnormal_cardiovascular_devel0.41134780
122MP0004859_abnormal_synaptic_plasticity0.40755709
123MP0010030_abnormal_orbit_morphology0.40242760
124MP0001879_abnormal_lymphatic_vessel0.39478838
125MP0003984_embryonic_growth_retardation0.39471916
126MP0002088_abnormal_embryonic_growth/wei0.38831214
127MP0005452_abnormal_adipose_tissue0.37896302
128MP0001784_abnormal_fluid_regulation0.34733146
129MP0005584_abnormal_enzyme/coenzyme_acti0.34024047
130MP0005275_abnormal_skin_tensile0.33453159
131MP0002118_abnormal_lipid_homeostasis0.32723653
132MP0005332_abnormal_amino_acid0.31874741
133MP0003959_abnormal_lean_body0.31261138
134MP0005167_abnormal_blood-brain_barrier0.29532525
135MP0005448_abnormal_energy_balance0.29374624
136MP0005595_abnormal_vascular_smooth0.27756768
137* MP0001614_abnormal_blood_vessel0.27723894
138MP0003122_maternal_imprinting0.26814392
139MP0000767_abnormal_smooth_muscle0.26059447
140MP0003953_abnormal_hormone_level0.24727847
141MP0009672_abnormal_birth_weight0.24640188
142MP0004147_increased_porphyrin_level0.23592176

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.04440532
2Ventricular tachycardia (HP:0004756)6.00911635
3Exercise-induced muscle cramps (HP:0003710)5.68750358
4Exercise-induced myalgia (HP:0003738)5.59834220
5Calf muscle hypertrophy (HP:0008981)5.51809645
6Atrial fibrillation (HP:0005110)5.34502978
7Myoglobinuria (HP:0002913)5.17098687
8Muscle hypertrophy of the lower extremities (HP:0008968)5.07877743
9Primary atrial arrhythmia (HP:0001692)5.05955586
10Supraventricular tachycardia (HP:0004755)4.91317581
11Supraventricular arrhythmia (HP:0005115)4.81528762
12Muscle fiber splitting (HP:0003555)4.63993951
13Abnormality of the calf musculature (HP:0001430)4.62204852
14Lipoatrophy (HP:0100578)4.62189275
15Subaortic stenosis (HP:0001682)4.55176891
16Abnormality of the left ventricular outflow tract (HP:0011103)4.55176891
17Bundle branch block (HP:0011710)4.49785717
18Protrusio acetabuli (HP:0003179)4.36369424
19Palpitations (HP:0001962)4.25800969
20Hyporeflexia of lower limbs (HP:0002600)4.19959082
21Asymmetric septal hypertrophy (HP:0001670)4.19195773
22Syncope (HP:0001279)4.07639884
23Abnormality of glycolipid metabolism (HP:0010969)4.05131063
24Abnormality of liposaccharide metabolism (HP:0010968)4.05131063
25Abnormality of glycosphingolipid metabolism (HP:0004343)4.05131063
26Right ventricular cardiomyopathy (HP:0011663)4.02317565
27Prolonged QT interval (HP:0001657)3.98793339
28Vertebral compression fractures (HP:0002953)3.94431847
29Dilated cardiomyopathy (HP:0001644)3.84910365
30Rhabdomyolysis (HP:0003201)3.74268953
31EMG: myopathic abnormalities (HP:0003458)3.73577553
32Ventricular arrhythmia (HP:0004308)3.70749822
33Heart block (HP:0012722)3.64480071
34Ventricular fibrillation (HP:0001663)3.62575765
35Abnormal mitochondria in muscle tissue (HP:0008316)3.59765298
36Acute necrotizing encephalopathy (HP:0006965)3.53549932
37Myotonia (HP:0002486)3.49878014
38Increased connective tissue (HP:0009025)3.48483202
39Abnormal atrioventricular conduction (HP:0005150)3.43474498
40Nuclear cataract (HP:0100018)3.42113951
41Difficulty running (HP:0009046)3.38732081
42Atrioventricular block (HP:0001678)3.36709082
43Hepatic necrosis (HP:0002605)3.32153838
44Axonal loss (HP:0003447)3.31011782
45Premature rupture of membranes (HP:0001788)3.28717913
46Acute encephalopathy (HP:0006846)3.24146150
47Ketoacidosis (HP:0001993)3.17915910
48Dysostosis multiplex (HP:0000943)3.13835491
49Abnormal EKG (HP:0003115)3.06173929
50Systemic lupus erythematosus (HP:0002725)2.92712966
51Progressive macrocephaly (HP:0004481)2.91810281
52Hepatocellular necrosis (HP:0001404)2.91208063
53Increased muscle lipid content (HP:0009058)2.89758476
54Spinal rigidity (HP:0003306)2.89341983
55Left ventricular hypertrophy (HP:0001712)2.82818451
56Mitochondrial inheritance (HP:0001427)2.82146041
57Cerebral aneurysm (HP:0004944)2.76049023
58Hypoglycemic coma (HP:0001325)2.71082205
59Muscle stiffness (HP:0003552)2.69483016
60Increased CSF lactate (HP:0002490)2.67812414
61Round ear (HP:0100830)2.65563274
62Difficulty climbing stairs (HP:0003551)2.65310560
63Retinal atrophy (HP:0001105)2.62836300
64Ragged-red muscle fibers (HP:0003200)2.61613485
65Conjunctival hamartoma (HP:0100780)2.58787699
66Neurofibrillary tangles (HP:0002185)2.57690265
67Pheochromocytoma (HP:0002666)2.57380356
68Abnormality of polysaccharide metabolism (HP:0011012)2.54133995
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54133995
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54133995
71Increased variability in muscle fiber diameter (HP:0003557)2.53781790
72Cerebral edema (HP:0002181)2.51801776
73Shallow orbits (HP:0000586)2.50241630
74Mucopolysacchariduria (HP:0008155)2.49753101
75Urinary glycosaminoglycan excretion (HP:0003541)2.49753101
76Testicular atrophy (HP:0000029)2.45816516
77Exercise intolerance (HP:0003546)2.45176876
78Achilles tendon contracture (HP:0001771)2.42473126
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41763469
80Dicarboxylic aciduria (HP:0003215)2.41763469
81Increased intramyocellular lipid droplets (HP:0012240)2.38884963
82Obstructive sleep apnea (HP:0002870)2.38485762
83Respiratory failure (HP:0002878)2.37944119
84Cervical subluxation (HP:0003308)2.36516907
85Lactic acidosis (HP:0003128)2.36125915
86Oligomenorrhea (HP:0000876)2.35411023
87Congenital glaucoma (HP:0001087)2.34991051
88Myopathic facies (HP:0002058)2.34832399
89Abnormality of fatty-acid metabolism (HP:0004359)2.33303197
90Centrally nucleated skeletal muscle fibers (HP:0003687)2.32739677
91Acanthosis nigricans (HP:0000956)2.31983277
92Type 1 muscle fiber predominance (HP:0003803)2.31947183
93Supranuclear gaze palsy (HP:0000605)2.31743005
94Hamartoma of the eye (HP:0010568)2.31657729
95Buphthalmos (HP:0000557)2.30459152
96Hypercortisolism (HP:0001578)2.29593005
97Neuroendocrine neoplasm (HP:0100634)2.27988766
98Ketosis (HP:0001946)2.26911391
99Muscle fiber inclusion bodies (HP:0100299)2.26847573
100Stridor (HP:0010307)2.26843498
101Bladder diverticulum (HP:0000015)2.26756520
102Cerebral inclusion bodies (HP:0100314)2.25263533
103Abnormality of skeletal muscle fiber size (HP:0012084)2.24940146
104Bulbar palsy (HP:0001283)2.23416047
105Mitral regurgitation (HP:0001653)2.22584357
106Distal lower limb amyotrophy (HP:0008944)2.21989445
107Limb-girdle muscle atrophy (HP:0003797)2.20147466
108Palmoplantar keratoderma (HP:0000982)2.19836409
109Esophageal neoplasm (HP:0100751)2.19313927
110Neoplasm of head and neck (HP:0012288)2.19313927
111Slender build (HP:0001533)2.18989412
112Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18492877
113Neoplasm of the adrenal gland (HP:0100631)2.18128095
114Fragile skin (HP:0001030)2.17687594
115Joint stiffness (HP:0001387)2.17660033
116Hyperparathyroidism (HP:0000843)2.17380386
117Abnormality of the Achilles tendon (HP:0005109)2.15452585
118Distal lower limb muscle weakness (HP:0009053)2.13076217
119Ulnar deviation of the wrist (HP:0003049)2.12097335
120Distal upper limb amyotrophy (HP:0007149)2.12067116
121Upper limb amyotrophy (HP:0009129)2.12067116
122Nemaline bodies (HP:0003798)2.10028087
123Athetosis (HP:0002305)2.09413545
124J-shaped sella turcica (HP:0002680)2.09077323
125Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07837644
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07837644
127Large for gestational age (HP:0001520)2.07431505
128Neck muscle weakness (HP:0000467)2.06217508
129Hyperacusis (HP:0010780)2.04822599
130Aortic aneurysm (HP:0004942)2.04432595
131Hypertriglyceridemia (HP:0002155)2.04248419
132Foot dorsiflexor weakness (HP:0009027)2.04097621
133Blue sclerae (HP:0000592)2.03693887
134Wormian bones (HP:0002645)2.03018962
135Turricephaly (HP:0000262)2.02984922
136Ankle contracture (HP:0006466)2.01759010
137Dysmetric saccades (HP:0000641)1.99791261
138Abnormality of complement system (HP:0005339)1.99108555
139Vascular tortuosity (HP:0004948)1.99023314
140Areflexia of lower limbs (HP:0002522)1.98810710
141Complement deficiency (HP:0004431)1.98540490
142Increased cerebral lipofuscin (HP:0011813)1.95564190
143Mesangial abnormality (HP:0001966)1.95411158
144EMG: neuropathic changes (HP:0003445)1.91744725
145Mildly elevated creatine phosphokinase (HP:0008180)1.88931087
146Lymphangioma (HP:0100764)1.88171718
147Sudden cardiac death (HP:0001645)1.86885330
148Emphysema (HP:0002097)1.86786847
149Multiple enchondromatosis (HP:0005701)1.86460381
150Abnormality of alanine metabolism (HP:0010916)1.86429098
151Hyperalaninemia (HP:0003348)1.86429098
152Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86429098
153Biconcave vertebral bodies (HP:0004586)1.85150236
154Progressive muscle weakness (HP:0003323)1.83980200
155Hyperglycinuria (HP:0003108)1.83163765
156Loss of speech (HP:0002371)1.82419335
157Growth hormone excess (HP:0000845)1.81848545
158Tinnitus (HP:0000360)1.81523777
159Generalized aminoaciduria (HP:0002909)1.80986844
160Glomerulonephritis (HP:0000099)1.79461719
161Lipid accumulation in hepatocytes (HP:0006561)1.78579896
162Neoplasm of the peripheral nervous system (HP:0100007)1.78264043
163Generalized muscle weakness (HP:0003324)1.78211607
164Distal arthrogryposis (HP:0005684)1.77896404
165Venous abnormality (HP:0002624)1.77676610
166Congestive heart failure (HP:0001635)1.77593354
167Hyperthyroidism (HP:0000836)1.76467593
168Abnormality of the foot musculature (HP:0001436)1.75690128
169Hyperinsulinemic hypoglycemia (HP:0000825)1.73794643
170Broad metatarsal (HP:0001783)1.71909692
171Hypercalcemia (HP:0003072)1.71283002
172Diaphragmatic weakness (HP:0009113)1.70157512
173Generalized amyotrophy (HP:0003700)1.69810855
174Genu recurvatum (HP:0002816)1.68185332
175Xanthomatosis (HP:0000991)1.67839294
176Skin nodule (HP:0200036)1.66605922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.08320511
2TRIB34.04352139
3PHKG13.84689849
4PHKG23.84689849
5LMTK23.72390841
6PKN23.62529870
7PDK33.10961875
8PDK43.10961875
9MYLK3.05981382
10OBSCN3.02705299
11BCKDK2.99228391
12DMPK2.68537852
13NEK12.48467062
14PINK12.44471277
15TESK12.20619180
16PRPF4B2.19091921
17IRAK32.13265074
18ARAF2.04045283
19PDK21.66492404
20PRKD31.65052293
21LIMK11.62207638
22ILK1.51283440
23MUSK1.50265564
24PIM21.50220185
25ABL21.48193645
26PIK3CA1.47363349
27WNK41.44353055
28MOS1.43674063
29TGFBR21.35108630
30ICK1.34151008
31TAOK21.33840746
32MAP3K131.28384252
33EEF2K1.28297318
34RIPK11.28280817
35STK241.24629018
36PAK31.23676196
37PRKD11.22397361
38CDC42BPA1.18724064
39PDGFRA1.17817916
40TIE11.15350908
41MARK21.12946251
42SMG11.12920113
43NME21.10774555
44DAPK31.06518677
45MAP3K71.05496294
46CAMK2D1.04384297
47LATS21.04148660
48STK381.04073171
49PTK21.03972206
50MAP3K101.03447504
51GRK71.02738126
52TBK10.98342841
53EPHB10.93284050
54PRKAA10.92832393
55ROCK10.88688780
56CAMK40.88603602
57MAPK120.87916198
58NTRK10.85946870
59BRAF0.85591057
60MARK30.83008151
61RPS6KC10.82261762
62RPS6KL10.82261762
63FLT30.81154345
64HIPK20.80613060
65UHMK10.80343503
66FGFR40.77740897
67MAPK70.77170625
68ERN10.75502277
69MAPK40.75453091
70SIK10.73308360
71WNK10.72835206
72PRKAA20.71260361
73RPS6KA60.70363319
74CAMK10.65860092
75PAK20.62608073
76MAP3K110.62591240
77RIPK40.61626492
78PAK60.60911475
79MAPKAPK30.60426294
80STK38L0.60392413
81PAK40.60309077
82IRAK20.60126514
83CAMK2B0.59714160
84CAMK1D0.58743972
85MAP2K30.57903609
86PRKD20.57178823
87SIK20.55854796
88MAP2K60.55601550
89AKT20.55079357
90EPHB20.53842461
91MAP2K20.53272333
92ROCK20.52420925
93MARK10.52287312
94MAP3K50.51902498
95CAMK1G0.51681466
96CAMK2A0.50885855
97NME10.50256733
98PRKCH0.49199255
99DYRK1B0.49011942
100TNK20.48998448
101NEK90.48556951
102TAOK10.48121358
103BMX0.48081218
104KSR20.47744089
105DDR20.47286353
106GSK3A0.47211019
107PTK2B0.46781020
108PDPK10.46342685
109RPS6KA10.45639468
110PRKACG0.44906927
111MAP2K40.44834135
112TYK20.44439381
113LRRK20.43175752
114GRK50.43114953
115MAP3K90.42005194
116PDGFRB0.41777728
117RET0.40648213
118STK40.39490630
119MTOR0.38920811
120PRKACB0.38391289
121PRKG20.37976655
122PRKACA0.37745236
123RPS6KA20.37316755
124MAP3K60.34357134
125PDK10.32190459
126CAMKK10.31914653
127MAP3K40.31409628
128CAMK2G0.31154622
129PTK60.29056259
130TYRO30.28309792
131MAP3K10.27768284
132RPS6KA30.26180013
133MAPK110.25932020
134TRPM70.25118619
135KDR0.24388864
136PRKCE0.22547820
137ALK0.22365201
138MAP3K30.22098814
139NTRK30.21210993
140SGK10.20055664
141PKN10.17714120

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.92284463
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.43150489
3Cardiac muscle contraction_Homo sapiens_hsa042604.05567262
4Parkinsons disease_Homo sapiens_hsa050123.50286676
5Oxidative phosphorylation_Homo sapiens_hsa001903.41692513
6Other glycan degradation_Homo sapiens_hsa005113.23956318
7Propanoate metabolism_Homo sapiens_hsa006403.15836795
8Dilated cardiomyopathy_Homo sapiens_hsa054142.94829369
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.72268769
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.69142573
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62329538
12Alzheimers disease_Homo sapiens_hsa050102.57272370
13Fatty acid degradation_Homo sapiens_hsa000712.51896613
14Carbon metabolism_Homo sapiens_hsa012002.50041404
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34503207
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22734372
17Huntingtons disease_Homo sapiens_hsa050162.20306945
18Fatty acid metabolism_Homo sapiens_hsa012122.14840990
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.07467282
20Lysosome_Homo sapiens_hsa041422.06908923
21Prion diseases_Homo sapiens_hsa050201.89125280
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88690487
23Pyruvate metabolism_Homo sapiens_hsa006201.78342356
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70588039
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58422736
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.47463813
27Biosynthesis of amino acids_Homo sapiens_hsa012301.36259737
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33574599
29Butanoate metabolism_Homo sapiens_hsa006501.27118944
30Vibrio cholerae infection_Homo sapiens_hsa051101.21959471
31Pentose phosphate pathway_Homo sapiens_hsa000301.15232026
32ECM-receptor interaction_Homo sapiens_hsa045121.15210082
33PPAR signaling pathway_Homo sapiens_hsa033201.13512642
34Synaptic vesicle cycle_Homo sapiens_hsa047211.11534374
35Fatty acid biosynthesis_Homo sapiens_hsa000611.11374114
36Viral myocarditis_Homo sapiens_hsa054161.08006754
37Glucagon signaling pathway_Homo sapiens_hsa049221.07398703
38Insulin signaling pathway_Homo sapiens_hsa049101.05983074
39Bladder cancer_Homo sapiens_hsa052191.01265716
40Adipocytokine signaling pathway_Homo sapiens_hsa049200.99934005
41Insulin resistance_Homo sapiens_hsa049310.97089045
42* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95213476
43Osteoclast differentiation_Homo sapiens_hsa043800.93755710
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90306070
45AMPK signaling pathway_Homo sapiens_hsa041520.86518296
46Amoebiasis_Homo sapiens_hsa051460.83614877
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.83072236
48Malaria_Homo sapiens_hsa051440.81901162
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81427736
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81080271
51Arginine biosynthesis_Homo sapiens_hsa002200.80955040
52Starch and sucrose metabolism_Homo sapiens_hsa005000.80518558
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.80266059
54Fatty acid elongation_Homo sapiens_hsa000620.79816962
55Chronic myeloid leukemia_Homo sapiens_hsa052200.78829405
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78564049
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77716492
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.76620119
59Cocaine addiction_Homo sapiens_hsa050300.76168563
60Galactose metabolism_Homo sapiens_hsa000520.75423893
61Lysine degradation_Homo sapiens_hsa003100.75126451
62Type II diabetes mellitus_Homo sapiens_hsa049300.74144754
63Fructose and mannose metabolism_Homo sapiens_hsa000510.73374525
64Calcium signaling pathway_Homo sapiens_hsa040200.71447118
65Acute myeloid leukemia_Homo sapiens_hsa052210.71408633
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70307679
67Phagosome_Homo sapiens_hsa041450.68761394
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68149045
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67924141
70HIF-1 signaling pathway_Homo sapiens_hsa040660.67854537
71Oxytocin signaling pathway_Homo sapiens_hsa049210.67593261
72Tyrosine metabolism_Homo sapiens_hsa003500.65147899
73Insulin secretion_Homo sapiens_hsa049110.64545279
74Collecting duct acid secretion_Homo sapiens_hsa049660.62097314
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61535071
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61468886
77Pertussis_Homo sapiens_hsa051330.61465248
78beta-Alanine metabolism_Homo sapiens_hsa004100.59726826
79Gastric acid secretion_Homo sapiens_hsa049710.59650895
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58994408
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57049237
82Toxoplasmosis_Homo sapiens_hsa051450.56554346
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56476530
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55840857
85Arginine and proline metabolism_Homo sapiens_hsa003300.53959400
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53525191
87Endocytosis_Homo sapiens_hsa041440.53474354
88Renin secretion_Homo sapiens_hsa049240.53355536
89Staphylococcus aureus infection_Homo sapiens_hsa051500.52344303
90Tryptophan metabolism_Homo sapiens_hsa003800.51437954
91mTOR signaling pathway_Homo sapiens_hsa041500.50635836
92Pancreatic cancer_Homo sapiens_hsa052120.50392330
93Rheumatoid arthritis_Homo sapiens_hsa053230.50337976
94Salmonella infection_Homo sapiens_hsa051320.49246013
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.49147599
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47786817
97B cell receptor signaling pathway_Homo sapiens_hsa046620.47508491
98cAMP signaling pathway_Homo sapiens_hsa040240.47471982
99Circadian entrainment_Homo sapiens_hsa047130.46674121
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46423391
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46210208
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46148006
103MAPK signaling pathway_Homo sapiens_hsa040100.45467866
104Ovarian steroidogenesis_Homo sapiens_hsa049130.45407174
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45358344
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.45265769
107* Focal adhesion_Homo sapiens_hsa045100.44336464
108Gap junction_Homo sapiens_hsa045400.43951111
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43008984
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42077590
111Non-small cell lung cancer_Homo sapiens_hsa052230.41974452
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36803124
113Nitrogen metabolism_Homo sapiens_hsa009100.35934352
114Peroxisome_Homo sapiens_hsa041460.35518117
115Phenylalanine metabolism_Homo sapiens_hsa003600.35508741
116Tight junction_Homo sapiens_hsa045300.35042973
117VEGF signaling pathway_Homo sapiens_hsa043700.31923208
118Cholinergic synapse_Homo sapiens_hsa047250.29877311
119Long-term potentiation_Homo sapiens_hsa047200.29349414
120Salivary secretion_Homo sapiens_hsa049700.28065646
121GnRH signaling pathway_Homo sapiens_hsa049120.27808839
122Circadian rhythm_Homo sapiens_hsa047100.27743066
123Estrogen signaling pathway_Homo sapiens_hsa049150.26507689
124Taste transduction_Homo sapiens_hsa047420.25728202
125Glycerolipid metabolism_Homo sapiens_hsa005610.24048506
126Melanogenesis_Homo sapiens_hsa049160.23505804
127Metabolic pathways_Homo sapiens_hsa011000.23189032
128GABAergic synapse_Homo sapiens_hsa047270.21449418
129Morphine addiction_Homo sapiens_hsa050320.20135222
130Proteoglycans in cancer_Homo sapiens_hsa052050.19997018
131Dorso-ventral axis formation_Homo sapiens_hsa043200.18884749
132Renal cell carcinoma_Homo sapiens_hsa052110.18378563
133Notch signaling pathway_Homo sapiens_hsa043300.17860507
134Olfactory transduction_Homo sapiens_hsa047400.17616842
135Pancreatic secretion_Homo sapiens_hsa049720.17116244
136Glioma_Homo sapiens_hsa052140.16764975
137Dopaminergic synapse_Homo sapiens_hsa047280.16757799
138Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16721596
139Adherens junction_Homo sapiens_hsa045200.15616698
140Bile secretion_Homo sapiens_hsa049760.14878134
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.14557569
142Fat digestion and absorption_Homo sapiens_hsa049750.14125551
143Sulfur relay system_Homo sapiens_hsa041220.13530440
144Amphetamine addiction_Homo sapiens_hsa050310.12050031

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