VENTX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.69168528
2behavioral response to nicotine (GO:0035095)4.06235870
3negative regulation of mast cell activation (GO:0033004)3.95752007
4L-fucose metabolic process (GO:0042354)3.94180437
5L-fucose catabolic process (GO:0042355)3.94180437
6fucose catabolic process (GO:0019317)3.94180437
7activated T cell proliferation (GO:0050798)3.84027445
8piRNA metabolic process (GO:0034587)3.70701923
9negative regulation of interleukin-1 production (GO:0032692)3.56992973
10negative regulation of interleukin-1 beta production (GO:0032691)3.43533688
11adaptation of signaling pathway (GO:0023058)3.37043374
12tryptophan catabolic process (GO:0006569)3.24719791
13indole-containing compound catabolic process (GO:0042436)3.24719791
14indolalkylamine catabolic process (GO:0046218)3.24719791
15platelet dense granule organization (GO:0060155)3.18148811
16regulation of mast cell activation (GO:0033003)3.15444847
17respiratory chain complex IV assembly (GO:0008535)3.09907744
18regulation of meiosis I (GO:0060631)3.09609212
19indolalkylamine metabolic process (GO:0006586)3.08905225
20positive regulation of defense response to virus by host (GO:0002230)2.97391841
21cytidine deamination (GO:0009972)2.96555161
22cytidine metabolic process (GO:0046087)2.96555161
23cytidine catabolic process (GO:0006216)2.96555161
24cytochrome complex assembly (GO:0017004)2.95347320
25DNA methylation involved in gamete generation (GO:0043046)2.92285686
26positive regulation by symbiont of host defense response (GO:0052509)2.90972364
27modulation by symbiont of host defense response (GO:0052031)2.90972364
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90972364
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90972364
30positive regulation by organism of defense response of other organism involved in symbiotic interact2.90972364
31modulation by symbiont of host immune response (GO:0052553)2.90972364
32positive regulation of interleukin-1 beta secretion (GO:0050718)2.89261636
33positive regulation of mast cell activation (GO:0033005)2.88709108
34negative regulation of telomere maintenance (GO:0032205)2.88122188
35kynurenine metabolic process (GO:0070189)2.87665954
36tryptophan metabolic process (GO:0006568)2.87114533
37phosphatidylinositol acyl-chain remodeling (GO:0036149)2.86422740
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82036764
39amine catabolic process (GO:0009310)2.74403164
40cellular biogenic amine catabolic process (GO:0042402)2.74403164
41basic amino acid transport (GO:0015802)2.70528309
42water-soluble vitamin biosynthetic process (GO:0042364)2.70237867
43positive regulation of interleukin-1 secretion (GO:0050716)2.69673859
44response to pheromone (GO:0019236)2.68506710
45negative regulation of interleukin-12 production (GO:0032695)2.66376912
46protein-cofactor linkage (GO:0018065)2.65915717
47sulfation (GO:0051923)2.64085253
48neutrophil activation (GO:0042119)2.63307880
49pyrimidine ribonucleoside catabolic process (GO:0046133)2.61022863
50microglial cell activation (GO:0001774)2.59314004
51kidney morphogenesis (GO:0060993)2.59053408
52protein complex biogenesis (GO:0070271)2.58835716
53positive regulation of T-helper 1 type immune response (GO:0002827)2.58387481
54preassembly of GPI anchor in ER membrane (GO:0016254)2.56699094
55regulation of interleukin-6 biosynthetic process (GO:0045408)2.56183765
56detection of light stimulus involved in sensory perception (GO:0050962)2.56131599
57detection of light stimulus involved in visual perception (GO:0050908)2.56131599
58regulation of interleukin-1 beta secretion (GO:0050706)2.55412937
59protein polyglutamylation (GO:0018095)2.54211512
60neutrophil activation involved in immune response (GO:0002283)2.53665791
61axoneme assembly (GO:0035082)2.52986934
62glycerophospholipid catabolic process (GO:0046475)2.51982252
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51959088
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.51959088
65regulation of translation, ncRNA-mediated (GO:0045974)2.51959088
66protein K11-linked deubiquitination (GO:0035871)2.51499939
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48367497
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48367497
69RNA destabilization (GO:0050779)2.48218684
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47939141
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.46821934
72cellular extravasation (GO:0045123)2.45795326
73mitochondrial respiratory chain complex assembly (GO:0033108)2.42310682
74regulation of action potential (GO:0098900)2.41502916
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40967396
76positive regulation of prostaglandin secretion (GO:0032308)2.39635346
77positive regulation of oligodendrocyte differentiation (GO:0048714)2.39598037
78male meiosis I (GO:0007141)2.38225395
79mitochondrial respiratory chain complex I assembly (GO:0032981)2.37784052
80NADH dehydrogenase complex assembly (GO:0010257)2.37784052
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.37784052
82regulation of mesoderm development (GO:2000380)2.37644567
83response to xenobiotic stimulus (GO:0009410)2.37034997
84positive regulation of gamma-delta T cell activation (GO:0046645)2.35991406
85neutrophil mediated immunity (GO:0002446)2.35692956
86epithelial cilium movement (GO:0003351)2.35464224
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34979875
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.34979875
89pseudouridine synthesis (GO:0001522)2.34881275
90positive regulation of mast cell activation involved in immune response (GO:0033008)2.33906834
91positive regulation of mast cell degranulation (GO:0043306)2.33906834
92multicellular organism reproduction (GO:0032504)2.33639799
93phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.32912240
94regulation of B cell receptor signaling pathway (GO:0050855)2.32034112
95photoreceptor cell maintenance (GO:0045494)2.31699749
96regulation of memory T cell differentiation (GO:0043380)2.30069611
97somite rostral/caudal axis specification (GO:0032525)2.29927483
98granulocyte activation (GO:0036230)2.29320765
99cellular response to ATP (GO:0071318)2.28359922
100positive regulation of antigen processing and presentation (GO:0002579)2.27982005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.35110536
2VDR_22108803_ChIP-Seq_LS180_Human3.41690688
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.84701116
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51119635
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.41409797
6GBX2_23144817_ChIP-Seq_PC3_Human2.27806522
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.08936998
8IGF1R_20145208_ChIP-Seq_DFB_Human2.08760073
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06341706
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01276752
11EZH2_22144423_ChIP-Seq_EOC_Human1.98375176
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94224438
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86642840
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.84302572
15P300_19829295_ChIP-Seq_ESCs_Human1.70071202
16* TP53_22573176_ChIP-Seq_HFKS_Human1.69154586
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67771813
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65698241
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.61059445
20GATA3_21878914_ChIP-Seq_MCF-7_Human1.58682528
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58089987
22BCAT_22108803_ChIP-Seq_LS180_Human1.57426401
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54155629
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53240751
25IRF1_19129219_ChIP-ChIP_H3396_Human1.52606392
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49972835
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49199633
28FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48941726
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.48941726
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48198090
31ER_23166858_ChIP-Seq_MCF-7_Human1.46012660
32NANOG_19829295_ChIP-Seq_ESCs_Human1.45951758
33SOX2_19829295_ChIP-Seq_ESCs_Human1.45951758
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45268829
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44192428
36EWS_26573619_Chip-Seq_HEK293_Human1.43266831
37GATA3_26560356_Chip-Seq_TH2_Human1.42503026
38TAF15_26573619_Chip-Seq_HEK293_Human1.40866525
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38327922
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35293035
41REST_21632747_ChIP-Seq_MESCs_Mouse1.34754621
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.33272830
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33011417
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30314448
45NCOR_22424771_ChIP-Seq_293T_Human1.29616635
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27787806
47AR_20517297_ChIP-Seq_VCAP_Human1.27206839
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27076376
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27076376
50ERA_21632823_ChIP-Seq_H3396_Human1.26860447
51MYC_19829295_ChIP-Seq_ESCs_Human1.23242855
52MYC_18940864_ChIP-ChIP_HL60_Human1.22766233
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22685166
54NANOG_20526341_ChIP-Seq_ESCs_Human1.21844753
55HOXB7_26014856_ChIP-Seq_BT474_Human1.20794660
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19977939
57OCT4_20526341_ChIP-Seq_ESCs_Human1.19850786
58GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.18647468
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17682242
60TCF4_23295773_ChIP-Seq_U87_Human1.17475830
61TAF2_19829295_ChIP-Seq_ESCs_Human1.17434865
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.16183266
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16063578
64VDR_23849224_ChIP-Seq_CD4+_Human1.15058080
65STAT3_23295773_ChIP-Seq_U87_Human1.13410571
66CBP_20019798_ChIP-Seq_JUKART_Human1.13311691
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13311691
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.12801153
69TCF4_22108803_ChIP-Seq_LS180_Human1.12404173
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10150957
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09996682
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09278664
73RUNX2_22187159_ChIP-Seq_PCA_Human1.08605883
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08544729
75AR_25329375_ChIP-Seq_VCAP_Human1.08493619
76FUS_26573619_Chip-Seq_HEK293_Human1.08315716
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08103658
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07873795
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.07585053
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.07552821
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05876482
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05768473
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05413733
84SMRT_27268052_Chip-Seq_Bcells_Human1.04971792
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03448783
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.01705577
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01284017
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01203016
89* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01021380
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.00970268
91FOXH1_21741376_ChIP-Seq_ESCs_Human1.00601127
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99919271
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.99313707
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99074276
95RAC3_21632823_ChIP-Seq_H3396_Human0.96567841
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96536512
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96049054
98IRF8_27001747_Chip-Seq_BMDM_Mouse0.95108205
99FOXP3_21729870_ChIP-Seq_TREG_Human0.93754760
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92872824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.31558536
2MP0003787_abnormal_imprinting3.29514731
3MP0003195_calcinosis2.80240583
4MP0003646_muscle_fatigue2.61204471
5MP0005671_abnormal_response_to2.59993377
6MP0001986_abnormal_taste_sensitivity2.55986062
7MP0002102_abnormal_ear_morphology2.51165030
8MP0003724_increased_susceptibility_to2.46968555
9MP0002837_dystrophic_cardiac_calcinosis2.45132108
10MP0005551_abnormal_eye_electrophysiolog2.07532268
11MP0000569_abnormal_digit_pigmentation2.05361724
12MP0008872_abnormal_physiological_respon1.96760626
13MP0002277_abnormal_respiratory_mucosa1.86065472
14MP0005084_abnormal_gallbladder_morpholo1.84002886
15MP0001968_abnormal_touch/_nociception1.77492518
16MP0001835_abnormal_antigen_presentation1.75072215
17MP0002148_abnormal_hypersensitivity_rea1.71519481
18MP0002254_reproductive_system_inflammat1.65251661
19MP0001800_abnormal_humoral_immune1.64550962
20MP0003806_abnormal_nucleotide_metabolis1.63848511
21MP0004142_abnormal_muscle_tone1.63452067
22MP0009764_decreased_sensitivity_to1.63129181
23MP0006082_CNS_inflammation1.61227285
24MP0003436_decreased_susceptibility_to1.58273263
25MP0004133_heterotaxia1.55793764
26MP0003011_delayed_dark_adaptation1.52765071
27MP0002163_abnormal_gland_morphology1.47837473
28MP0001790_abnormal_immune_system1.46756434
29MP0005387_immune_system_phenotype1.46756434
30MP0002419_abnormal_innate_immunity1.46711903
31MP0009785_altered_susceptibility_to1.46121518
32MP0000685_abnormal_immune_system1.44068815
33MP0002723_abnormal_immune_serum1.43459376
34MP0005646_abnormal_pituitary_gland1.43278753
35MP0009745_abnormal_behavioral_response1.38879544
36MP0002638_abnormal_pupillary_reflex1.37785123
37MP0002653_abnormal_ependyma_morphology1.37671847
38MP0006292_abnormal_olfactory_placode1.36807573
39MP0005253_abnormal_eye_physiology1.33946807
40MP0005000_abnormal_immune_tolerance1.32942933
41MP0002452_abnormal_antigen_presenting1.32807810
42MP0001501_abnormal_sleep_pattern1.31537572
43MP0002928_abnormal_bile_duct1.31159553
44MP0005645_abnormal_hypothalamus_physiol1.28858477
45MP0009046_muscle_twitch1.28644053
46MP0005174_abnormal_tail_pigmentation1.28198540
47MP0005075_abnormal_melanosome_morpholog1.27644508
48MP0002420_abnormal_adaptive_immunity1.27414386
49MP0001819_abnormal_immune_cell1.26666929
50MP0006072_abnormal_retinal_apoptosis1.26406511
51MP0002733_abnormal_thermal_nociception1.25299256
52MP0005379_endocrine/exocrine_gland_phen1.25167810
53MP0002138_abnormal_hepatobiliary_system1.25076504
54MP0005025_abnormal_response_to1.23283881
55MP0000427_abnormal_hair_cycle1.21296427
56MP0002736_abnormal_nociception_after1.20371381
57MP0002693_abnormal_pancreas_physiology1.18915168
58MP0002876_abnormal_thyroid_physiology1.18543377
59MP0003121_genomic_imprinting1.18202991
60MP0001485_abnormal_pinna_reflex1.17035508
61MP0003136_yellow_coat_color1.12090790
62MP0008875_abnormal_xenobiotic_pharmacok1.08817025
63MP0002735_abnormal_chemical_nociception1.06419204
64MP0000631_abnormal_neuroendocrine_gland1.06171958
65MP0001970_abnormal_pain_threshold1.05867262
66MP0005377_hearing/vestibular/ear_phenot1.02627669
67MP0003878_abnormal_ear_physiology1.02627669
68MP0005167_abnormal_blood-brain_barrier1.02262335
69MP0004147_increased_porphyrin_level0.99491360
70MP0008995_early_reproductive_senescence0.99169347
71MP0000372_irregular_coat_pigmentation0.95922455
72MP0001764_abnormal_homeostasis0.95637396
73MP0005410_abnormal_fertilization0.94713727
74MP0004885_abnormal_endolymph0.93815508
75MP0000470_abnormal_stomach_morphology0.92945835
76MP0005310_abnormal_salivary_gland0.92658469
77MP0001845_abnormal_inflammatory_respons0.89943882
78MP0003283_abnormal_digestive_organ0.87870733
79MP0003718_maternal_effect0.86808307
80MP0008058_abnormal_DNA_repair0.86269885
81MP0001919_abnormal_reproductive_system0.86119698
82MP0001486_abnormal_startle_reflex0.85961629
83MP0002272_abnormal_nervous_system0.85924676
84MP0000689_abnormal_spleen_morphology0.85269362
85MP0004742_abnormal_vestibular_system0.84901285
86MP0002405_respiratory_system_inflammati0.84104638
87MP0000716_abnormal_immune_system0.82416713
88MP0000230_abnormal_systemic_arterial0.80922151
89MP0005389_reproductive_system_phenotype0.80522626
90MP0004043_abnormal_pH_regulation0.80236016
91MP0001533_abnormal_skeleton_physiology0.79901671
92MP0001905_abnormal_dopamine_level0.78781347
93MP0006035_abnormal_mitochondrial_morpho0.78657144
94MP0005195_abnormal_posterior_eye0.78605228
95MP0008469_abnormal_protein_level0.78248617
96MP0001324_abnormal_eye_pigmentation0.76586141
97MP0002064_seizures0.76534022
98MP0002067_abnormal_sensory_capabilities0.75627389
99MP0003890_abnormal_embryonic-extraembry0.75309443
100MP0002572_abnormal_emotion/affect_behav0.74250641

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.03862739
2Stomatitis (HP:0010280)3.83848166
3Congenital stationary night blindness (HP:0007642)3.66479287
4Pancreatic fibrosis (HP:0100732)3.65699688
5Abolished electroretinogram (ERG) (HP:0000550)3.61138200
6True hermaphroditism (HP:0010459)3.58012427
7Molar tooth sign on MRI (HP:0002419)3.56554408
8Abnormality of midbrain morphology (HP:0002418)3.56554408
9Nephronophthisis (HP:0000090)3.17115382
10Type II lissencephaly (HP:0007260)3.15447323
11Decreased electroretinogram (ERG) amplitude (HP:0000654)3.02168069
12Abnormal rod and cone electroretinograms (HP:0008323)2.88871614
13Pendular nystagmus (HP:0012043)2.83247092
14Abnormality of the renal medulla (HP:0100957)2.71021046
15Abnormal drinking behavior (HP:0030082)2.70436234
16Polydipsia (HP:0001959)2.70436234
17Elevated erythrocyte sedimentation rate (HP:0003565)2.67033007
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58891853
19Retrobulbar optic neuritis (HP:0100654)2.58829292
20Optic neuritis (HP:0100653)2.58829292
21Chronic hepatic failure (HP:0100626)2.55912904
22Attenuation of retinal blood vessels (HP:0007843)2.54889481
23Abnormality of the renal cortex (HP:0011035)2.52303587
24Tubular atrophy (HP:0000092)2.49277501
25Stomach cancer (HP:0012126)2.44775794
26Decreased central vision (HP:0007663)2.44328315
27Myositis (HP:0100614)2.39683637
28Cystic liver disease (HP:0006706)2.36279445
29Medial flaring of the eyebrow (HP:0010747)2.34751731
30Abnormality of the pons (HP:0007361)2.32810078
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.32612983
32Polyuria (HP:0000103)2.28642184
33Hypoplasia of the pons (HP:0012110)2.28469921
34Orchitis (HP:0100796)2.21781120
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.17329091
36Abnormal biliary tract physiology (HP:0012439)2.15489256
37Bile duct proliferation (HP:0001408)2.15489256
38Hyperventilation (HP:0002883)2.13344499
393-Methylglutaconic aciduria (HP:0003535)2.12928161
40Cerebellar dysplasia (HP:0007033)2.09618427
41Lissencephaly (HP:0001339)2.09070030
42Progressive inability to walk (HP:0002505)2.07590600
43Congenital hepatic fibrosis (HP:0002612)2.04138226
44Retinal dysplasia (HP:0007973)2.03834155
45Hyperglycinemia (HP:0002154)2.03392401
46Anencephaly (HP:0002323)2.02880560
47Sclerocornea (HP:0000647)2.01867030
48Male pseudohermaphroditism (HP:0000037)2.01343430
49Recurrent cutaneous fungal infections (HP:0011370)2.01103550
50Chronic mucocutaneous candidiasis (HP:0002728)2.01103550
51Inability to walk (HP:0002540)2.00892923
52Asplenia (HP:0001746)2.00382899
53Agitation (HP:0000713)1.99994327
54Abnormality of the labia minora (HP:0012880)1.98846208
55Abnormality of DNA repair (HP:0003254)1.97656902
56Bilateral microphthalmos (HP:0007633)1.97129590
57Furrowed tongue (HP:0000221)1.96793849
58Acute necrotizing encephalopathy (HP:0006965)1.96085432
59Retinal atrophy (HP:0001105)1.94642367
60Recurrent bacterial skin infections (HP:0005406)1.92598851
61Absent/shortened dynein arms (HP:0200106)1.91491497
62Dynein arm defect of respiratory motile cilia (HP:0012255)1.91491497
63Encephalitis (HP:0002383)1.91436346
64Large for gestational age (HP:0001520)1.91327443
65Decreased circulating renin level (HP:0003351)1.89779076
66Increased corneal curvature (HP:0100692)1.89585448
67Keratoconus (HP:0000563)1.89585448
68Methylmalonic aciduria (HP:0012120)1.89566125
69Hypoplasia of the fovea (HP:0007750)1.88161083
70Aplasia/Hypoplasia of the fovea (HP:0008060)1.88161083
71Colon cancer (HP:0003003)1.87760600
72Mitochondrial inheritance (HP:0001427)1.87431464
73Recurrent fungal infections (HP:0002841)1.86863614
74Hypochromic microcytic anemia (HP:0004840)1.86411109
75Hypochromic anemia (HP:0001931)1.84676856
76Progressive macrocephaly (HP:0004481)1.82414232
77IgG deficiency (HP:0004315)1.81211316
78Methylmalonic acidemia (HP:0002912)1.80654712
79Hypomagnesemia (HP:0002917)1.78533082
80Increased CSF lactate (HP:0002490)1.78324872
81Clumsiness (HP:0002312)1.77181519
82Abnormal urine output (HP:0012590)1.74372786
83Constricted visual fields (HP:0001133)1.73033223
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71728752
85Abnormality of alanine metabolism (HP:0010916)1.71728752
86Hyperalaninemia (HP:0003348)1.71728752
87Hyperglycinuria (HP:0003108)1.71110707
88Increased neuronal autofluorescent lipopigment (HP:0002074)1.69688947
89Polyphagia (HP:0002591)1.68947049
90Recurrent abscess formation (HP:0002722)1.68734629
91Optic disc pallor (HP:0000543)1.68592417
92Neoplasm of the adrenal cortex (HP:0100641)1.68211040
93Acute encephalopathy (HP:0006846)1.67313007
94Episodic fever (HP:0001954)1.67265111
95Severe visual impairment (HP:0001141)1.67042453
96Protruding tongue (HP:0010808)1.65159157
97Keratoconjunctivitis (HP:0001096)1.63128593
98Hematochezia (HP:0002573)1.61719259
99Aplasia/Hypoplasia affecting the retina (HP:0008061)1.61311515
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61187594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.86574463
2ZAK3.07593869
3ADRBK23.00301786
4ACVR1B2.82943388
5TAOK32.56732987
6GRK12.34520720
7WNK32.31091917
8TXK2.21598970
9BMPR1B2.20427842
10NUAK12.15172278
11TLK11.84515593
12INSRR1.84239015
13DAPK21.78652419
14PINK11.77504034
15TNK21.72506839
16IRAK41.65223985
17MAP4K11.62893759
18MAP4K21.48260494
19MARK31.45108444
20RIPK41.43916417
21WNK41.39815065
22OXSR11.39006162
23CDK191.36724195
24FES1.33409428
25IKBKB1.30187401
26PTK2B1.15908373
27KIT1.14278925
28STK161.10985274
29MAPK131.10186374
30BLK1.07325577
31STK111.07308352
32TRIM281.07165171
33PHKG21.05740999
34PHKG11.05740999
35PRKCQ1.03842304
36IRAK11.03712545
37MKNK21.00112344
38TEC0.98841932
39BCKDK0.98175283
40SYK0.96048481
41MST40.94607368
42PAK30.94069298
43ADRBK10.94024581
44CASK0.93009637
45DYRK20.91593725
46PDK20.87806711
47MAP3K40.85022680
48NME10.83973319
49LYN0.82117037
50FGFR20.81568242
51FGR0.79540433
52IKBKE0.78906801
53ITK0.77079126
54CAMKK20.74159567
55MAP2K60.71416111
56CSK0.71229571
57CSF1R0.69568728
58BTK0.68688628
59LCK0.66531115
60PRKCE0.65152167
61GRK60.64623779
62MAP3K140.64557217
63PRKCG0.63657885
64TGFBR10.63516689
65TNIK0.63446508
66HCK0.63286719
67MATK0.62255305
68GRK70.62062524
69STK100.62001100
70CSNK1G20.58025698
71PIM10.57136529
72TYK20.57037348
73SIK20.54629148
74MAPK150.53849945
75NTRK30.53596725
76PLK20.49524084
77STK390.48800443
78MAP2K70.48059214
79MAP3K70.48007919
80PRKCZ0.47168255
81PKN10.47133778
82MKNK10.44100432
83CHUK0.44020942
84PRKAA20.43358613
85PLK30.42968187
86PRKD20.42850612
87CAMK10.40787108
88VRK10.40651495
89PRKACA0.39348695
90STK38L0.39096674
91PIK3CG0.38706039
92PRKCI0.36345163
93CSNK1G10.35889773
94JAK30.34942769
95CSNK1G30.34941733
96PLK40.34869627
97DYRK30.34836085
98ZAP700.33583756
99IRAK20.33201084
100NLK0.32681408

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.92706935
2Phototransduction_Homo sapiens_hsa047442.60054104
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59063500
4Linoleic acid metabolism_Homo sapiens_hsa005912.57530458
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20726429
6Oxidative phosphorylation_Homo sapiens_hsa001902.14403101
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.13304866
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.09155712
9Ether lipid metabolism_Homo sapiens_hsa005652.04613592
10Selenocompound metabolism_Homo sapiens_hsa004501.98485015
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84418198
12Graft-versus-host disease_Homo sapiens_hsa053321.83411782
13Type I diabetes mellitus_Homo sapiens_hsa049401.81292640
14Nitrogen metabolism_Homo sapiens_hsa009101.75058984
15Homologous recombination_Homo sapiens_hsa034401.73943680
16Asthma_Homo sapiens_hsa053101.73919321
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73236598
18Regulation of autophagy_Homo sapiens_hsa041401.68923016
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66750367
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65350818
21Allograft rejection_Homo sapiens_hsa053301.64907887
22Primary immunodeficiency_Homo sapiens_hsa053401.55305286
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54297854
24Staphylococcus aureus infection_Homo sapiens_hsa051501.47171193
25Fanconi anemia pathway_Homo sapiens_hsa034601.46978127
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46278582
27Autoimmune thyroid disease_Homo sapiens_hsa053201.45337217
28Parkinsons disease_Homo sapiens_hsa050121.42287882
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40846910
30Butanoate metabolism_Homo sapiens_hsa006501.39507300
31Collecting duct acid secretion_Homo sapiens_hsa049661.38998893
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38065528
33Protein export_Homo sapiens_hsa030601.37610887
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36631593
35Arachidonic acid metabolism_Homo sapiens_hsa005901.36092006
36Basal transcription factors_Homo sapiens_hsa030221.35308705
37Tryptophan metabolism_Homo sapiens_hsa003801.32868003
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28572192
39Nicotine addiction_Homo sapiens_hsa050331.27719593
40Rheumatoid arthritis_Homo sapiens_hsa053231.25268854
41Morphine addiction_Homo sapiens_hsa050321.18365900
42RNA polymerase_Homo sapiens_hsa030201.17600811
43Leishmaniasis_Homo sapiens_hsa051401.09925640
44Olfactory transduction_Homo sapiens_hsa047401.09844189
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07235764
46Hematopoietic cell lineage_Homo sapiens_hsa046401.06395089
47Peroxisome_Homo sapiens_hsa041461.03626944
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98934309
49RNA degradation_Homo sapiens_hsa030180.96819524
50Caffeine metabolism_Homo sapiens_hsa002320.95459633
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94103221
52Taste transduction_Homo sapiens_hsa047420.93367568
53Folate biosynthesis_Homo sapiens_hsa007900.90458078
54Osteoclast differentiation_Homo sapiens_hsa043800.89747269
55One carbon pool by folate_Homo sapiens_hsa006700.89417335
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84860228
57Dorso-ventral axis formation_Homo sapiens_hsa043200.84129160
58Antigen processing and presentation_Homo sapiens_hsa046120.82950806
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.82913015
60Glycerolipid metabolism_Homo sapiens_hsa005610.81943625
61Huntingtons disease_Homo sapiens_hsa050160.80708201
62Serotonergic synapse_Homo sapiens_hsa047260.78571107
63Tuberculosis_Homo sapiens_hsa051520.75081377
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74089296
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74067290
66Alzheimers disease_Homo sapiens_hsa050100.72327017
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70324775
68Legionellosis_Homo sapiens_hsa051340.69829694
69ABC transporters_Homo sapiens_hsa020100.69050620
70Mineral absorption_Homo sapiens_hsa049780.68230231
71Insulin secretion_Homo sapiens_hsa049110.67736052
72Chemical carcinogenesis_Homo sapiens_hsa052040.64844162
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.64558230
74Ovarian steroidogenesis_Homo sapiens_hsa049130.62446669
75Chemokine signaling pathway_Homo sapiens_hsa040620.61137248
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57457528
77Cardiac muscle contraction_Homo sapiens_hsa042600.56223985
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56196299
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55132971
80Retinol metabolism_Homo sapiens_hsa008300.55031840
81GABAergic synapse_Homo sapiens_hsa047270.54536092
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49140035
83African trypanosomiasis_Homo sapiens_hsa051430.48898556
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48586839
85Phagosome_Homo sapiens_hsa041450.47586964
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46544640
87Propanoate metabolism_Homo sapiens_hsa006400.45924608
88Sulfur relay system_Homo sapiens_hsa041220.43476004
89Non-homologous end-joining_Homo sapiens_hsa034500.43029150
90Fat digestion and absorption_Homo sapiens_hsa049750.42159736
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42052906
92Metabolic pathways_Homo sapiens_hsa011000.42020006
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40943930
94T cell receptor signaling pathway_Homo sapiens_hsa046600.40815171
95Type II diabetes mellitus_Homo sapiens_hsa049300.40449475
96Purine metabolism_Homo sapiens_hsa002300.37538158
97Circadian entrainment_Homo sapiens_hsa047130.36992159
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35990394
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.34937441
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.34138097

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