ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K9 demethylation (GO:0033169)	5.79839598
2	synapsis (GO:0007129)	4.95082007
3	nuclear pore complex assembly (GO:0051292)	4.85701315
4	DNA replication checkpoint (GO:0000076)	4.77815758
5	nuclear pore organization (GO:0006999)	4.53220513
6	formation of translation preinitiation complex (GO:0001731)	4.42231865
7	proteasome assembly (GO:0043248)	4.38200932
8	regulation of translational fidelity (GO:0006450)	4.28655329
9	diterpenoid biosynthetic process (GO:0016102)	4.20271665
10	mitotic metaphase plate congression (GO:0007080)	4.17389785
11	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	4.07751979
12	gas transport (GO:0015669)	4.06918315
13	regulation of histone H3-K4 methylation (GO:0051569)	4.00529837
14	resolution of meiotic recombination intermediates (GO:0000712)	3.98907598
15	DNA methylation involved in gamete generation (GO:0043046)	3.95633952
16	mitotic chromosome condensation (GO:0007076)	3.88867713
17	regulation of histone H3-K9 methylation (GO:0051570)	3.86084262
18	chromosome organization involved in meiosis (GO:0070192)	3.76762868
19	DNA replication initiation (GO:0006270)	3.75491484
20	male meiosis (GO:0007140)	3.75301759
21	mitotic nuclear envelope disassembly (GO:0007077)	3.73351884
22	binding of sperm to zona pellucida (GO:0007339)	3.71914102
23	pore complex assembly (GO:0046931)	3.70696156
24	mitotic sister chromatid segregation (GO:0000070)	3.67408328
25	sister chromatid segregation (GO:0000819)	3.57848925
26	protoporphyrinogen IX metabolic process (GO:0046501)	3.48265505
27	N-terminal protein amino acid acetylation (GO:0006474)	3.47098822
28	proline biosynthetic process (GO:0006561)	3.45653078
29	negative regulation of histone methylation (GO:0031061)	3.45450301
30	positive regulation of histone H3-K4 methylation (GO:0051571)	3.43184272
31	protein localization to kinetochore (GO:0034501)	3.42905959
32	nuclear envelope disassembly (GO:0051081)	3.42655999
33	membrane disassembly (GO:0030397)	3.42655999
34	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.42227109
35	erythrocyte development (GO:0048821)	3.40488874
36	metaphase plate congression (GO:0051310)	3.40014625
37	DNA strand elongation involved in DNA replication (GO:0006271)	3.39837789
38	DNA unwinding involved in DNA replication (GO:0006268)	3.37167331
39	oxygen transport (GO:0015671)	3.37015930
40	gonadal mesoderm development (GO:0007506)	3.34620284
41	DNA strand elongation (GO:0022616)	3.31992148
42	oxidative phosphorylation (GO:0006119)	3.31502518
43	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.30745367
44	synaptonemal complex assembly (GO:0007130)	3.30508598
45	terpenoid biosynthetic process (GO:0016114)	3.29657072
46	regulation of DNA methylation (GO:0044030)	3.29303793
47	protein localization to chromosome, centromeric region (GO:0071459)	3.28969865
48	telomere maintenance via semi-conservative replication (GO:0032201)	3.27411501
49	regulation of RNA export from nucleus (GO:0046831)	3.24095036
50	purine nucleobase biosynthetic process (GO:0009113)	3.21983804
51	male meiosis I (GO:0007141)	3.20128957
52	regulation of mitotic spindle organization (GO:0060236)	3.18993976
53	tRNA aminoacylation for protein translation (GO:0006418)	3.18564886
54	piRNA metabolic process (GO:0034587)	3.18161996
55	chromosome segregation (GO:0007059)	3.17228457
56	regulation of histone methylation (GO:0031060)	3.15469056
57	ribosomal small subunit assembly (GO:0000028)	3.14375456
58	phosphorelay signal transduction system (GO:0000160)	3.13124043
59	vitamin A metabolic process (GO:0006776)	3.08030758
60	DNA topological change (GO:0006265)	3.07343462
61	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.05436276
62	ribosome biogenesis (GO:0042254)	3.03916330
63	regulation of spindle organization (GO:0090224)	3.03616124
64	amino acid activation (GO:0043038)	3.03186465
65	tRNA aminoacylation (GO:0043039)	3.03186465
66	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.02179371
67	positive regulation of histone methylation (GO:0031062)	3.02002838
68	synaptonemal complex organization (GO:0070193)	3.00218381
69	response to vitamin A (GO:0033189)	3.00050246
70	ribosome assembly (GO:0042255)	2.99623826
71	meiosis I (GO:0007127)	2.97899184
72	ribosomal large subunit biogenesis (GO:0042273)	2.96743678
73	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.96388168
74	CENP-A containing nucleosome assembly (GO:0034080)	2.92963477
75	folic acid-containing compound biosynthetic process (GO:0009396)	2.92450754
76	one-carbon compound transport (GO:0019755)	2.92303404
77	establishment of chromosome localization (GO:0051303)	2.91093235
78	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.90710744
79	regulation of exit from mitosis (GO:0007096)	2.89853028
80	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.89655049
81	centriole replication (GO:0007099)	2.88107800
82	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.87169065
83	meiotic cell cycle process (GO:1903046)	2.86873712
84	meiotic cell cycle (GO:0051321)	2.85385117
85	ribonucleoprotein complex biogenesis (GO:0022613)	2.85085258
86	IMP biosynthetic process (GO:0006188)	2.83582816
87	regulation of translational elongation (GO:0006448)	2.82615344
88	regulation of chromosome segregation (GO:0051983)	2.82084616
89	negative regulation of chromosome segregation (GO:0051985)	2.82042281
90	mitotic recombination (GO:0006312)	2.81751648
91	attachment of spindle microtubules to kinetochore (GO:0008608)	2.81154928
92	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.81061378
93	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.81061378
94	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.81061378
95	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.81061378
96	negative regulation of sister chromatid segregation (GO:0033046)	2.81061378
97	sperm-egg recognition (GO:0035036)	2.80225630
98	mitotic spindle checkpoint (GO:0071174)	2.79829328
99	telomere maintenance via recombination (GO:0000722)	2.79262324
100	positive regulation of ligase activity (GO:0051351)	2.79229710

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.29818852
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.21389428
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.77221602
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.68388360
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.63716592
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.49052536
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.38706513
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.31083757
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.13430716
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.06214095
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02966575
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.95633208
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.92176403
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86685742
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.73543926
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.61834868
17	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.45156135
18	NCOR1_26117541_ChIP-Seq_K562_Human	2.30027435
19	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.28578245
20	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.27184232
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.26738541
22	XRN2_22483619_ChIP-Seq_HELA_Human	2.23187132
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.16577138
24	TTF2_22483619_ChIP-Seq_HELA_Human	2.13717739
25	AR_21909140_ChIP-Seq_LNCAP_Human	2.12243774
26	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.09638519
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09395778
28	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.08714038
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.04693523
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.02009769
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99608774
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97045908
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.90542657
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.84928405
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84301492
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.83335130
37	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.78741843
38	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.76060758
39	EZH2_22144423_ChIP-Seq_EOC_Human	1.75445746
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.74699371
41	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.74429141
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.68453931
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.64833726
44	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.62483730
45	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.61350376
46	GATA1_19941826_ChIP-Seq_K562_Human	1.58725620
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.58385129
48	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.55508178
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.54160829
50	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.52921918
51	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.49452262
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49353899
53	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49241194
54	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.48399050
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37917024
56	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.35469713
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.34828717
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.33970167
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.32051217
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.31889936
61	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.30626463
62	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.29556072
63	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26324372
64	CIITA_25753668_ChIP-Seq_RAJI_Human	1.18447477
65	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.15726598
66	VDR_22108803_ChIP-Seq_LS180_Human	1.15356378
67	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.13881417
68	GATA2_19941826_ChIP-Seq_K562_Human	1.12542969
69	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.12330389
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10467765
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.09449366
72	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.09211570
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06353610
74	TFEB_21752829_ChIP-Seq_HELA_Human	1.02244920
75	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.02158300
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00370149
77	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.00200406
78	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.99556993
79	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.98293659
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97261446
81	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.95722722
82	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.95722722
83	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.95722722
84	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.94849227
85	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93560331
86	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90240930
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.90073420
88	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87438651
89	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86090242
90	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.85349665
91	GATA1_22025678_ChIP-Seq_K562_Human	0.83895920
92	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.83572989
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.80612373
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.80091605
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.78700354
96	SPI1_23127762_ChIP-Seq_K562_Human	0.78293536
97	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.76963927
98	SCL_19346495_ChIP-Seq_HPC-7_Human	0.76502631
99	ZNF263_19887448_ChIP-Seq_K562_Human	0.75441764
100	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.75117982

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.50540644
2	MP0008058_abnormal_DNA_repair	4.00738488
3	MP0003718_maternal_effect	3.81608947
4	MP0004957_abnormal_blastocyst_morpholog	3.75374409
5	MP0004147_increased_porphyrin_level	3.63420393
6	MP0003111_abnormal_nucleus_morphology	3.37557400
7	MP0010094_abnormal_chromosome_stability	3.28235988
8	MP0009697_abnormal_copulation	3.22767163
9	MP0000678_abnormal_parathyroid_gland	3.14227102
10	MP0008995_early_reproductive_senescence	3.03233888
11	MP0003077_abnormal_cell_cycle	2.80520426
12	MP0006292_abnormal_olfactory_placode	2.73186130
13	MP0008932_abnormal_embryonic_tissue	2.62433482
14	MP0001929_abnormal_gametogenesis	2.26263734
15	MP0005410_abnormal_fertilization	2.25972887
16	MP0005451_abnormal_body_composition	2.19028435
17	MP0001730_embryonic_growth_arrest	2.09257861
18	MP0002132_abnormal_respiratory_system	2.07246421
19	MP0002210_abnormal_sex_determination	2.06924986
20	MP0003656_abnormal_erythrocyte_physiolo	2.04046387
21	MP0008057_abnormal_DNA_replication	2.03095076
22	MP0003786_premature_aging	2.01069915
23	MP0005360_urolithiasis	1.95680820
24	MP0008877_abnormal_DNA_methylation	1.95194036
25	MP0003186_abnormal_redox_activity	1.92891041
26	MP0004145_abnormal_muscle_electrophysio	1.82885708
27	MP0000372_irregular_coat_pigmentation	1.80256540
28	MP0006036_abnormal_mitochondrial_physio	1.76444597
29	MP0008007_abnormal_cellular_replicative	1.71528363
30	MP0003806_abnormal_nucleotide_metabolis	1.70024521
31	MP0000350_abnormal_cell_proliferation	1.63741059
32	MP0001545_abnormal_hematopoietic_system	1.61748566
33	MP0005397_hematopoietic_system_phenotyp	1.61748566
34	MP0006035_abnormal_mitochondrial_morpho	1.58645463
35	MP0003950_abnormal_plasma_membrane	1.57050400
36	MP0003699_abnormal_female_reproductive	1.52733730
37	MP0000653_abnormal_sex_gland	1.51623080
38	MP0003890_abnormal_embryonic-extraembry	1.50326149
39	MP0003698_abnormal_male_reproductive	1.47137862
40	MP0001697_abnormal_embryo_size	1.43840710
41	MP0001145_abnormal_male_reproductive	1.38302234
42	MP0001672_abnormal_embryogenesis/_devel	1.35991848
43	MP0005380_embryogenesis_phenotype	1.35991848
44	MP0002139_abnormal_hepatobiliary_system	1.34839557
45	MP0010234_abnormal_vibrissa_follicle	1.30044478
46	MP0005646_abnormal_pituitary_gland	1.29982710
47	MP0002161_abnormal_fertility/fecundity	1.28409415
48	MP0009840_abnormal_foam_cell	1.26453093
49	MP0002080_prenatal_lethality	1.25333396
50	MP0002160_abnormal_reproductive_system	1.22182528
51	MP0000313_abnormal_cell_death	1.20173733
52	MP0001661_extended_life_span	1.19573419
53	MP0005395_other_phenotype	1.19463296
54	MP0004233_abnormal_muscle_weight	1.17747896
55	MP0005171_absent_coat_pigmentation	1.11314240
56	MP0010307_abnormal_tumor_latency	1.09907746
57	MP0003136_yellow_coat_color	1.09219835
58	MP0001502_abnormal_circadian_rhythm	1.08702718
59	MP0005647_abnormal_sex_gland	1.07825139
60	MP0001764_abnormal_homeostasis	1.07612891
61	MP0001727_abnormal_embryo_implantation	1.06210703
62	MP0002084_abnormal_developmental_patter	1.03947668
63	MP0003984_embryonic_growth_retardation	1.03737270
64	MP0005083_abnormal_biliary_tract	1.03563582
65	MP0002086_abnormal_extraembryonic_tissu	1.02127498
66	MP0003959_abnormal_lean_body	0.99684042
67	MP0002088_abnormal_embryonic_growth/wei	0.98785862
68	MP0001119_abnormal_female_reproductive	0.98458711
69	MP0005636_abnormal_mineral_homeostasis	0.97810026
70	MP0000358_abnormal_cell_content/	0.96645864
71	MP0002085_abnormal_embryonic_tissue	0.94933689
72	MP0008789_abnormal_olfactory_epithelium	0.93834290
73	MP0005499_abnormal_olfactory_system	0.92660768
74	MP0005394_taste/olfaction_phenotype	0.92660768
75	MP0006276_abnormal_autonomic_nervous	0.88958551
76	MP0002249_abnormal_larynx_morphology	0.88892814
77	MP0000631_abnormal_neuroendocrine_gland	0.81388138
78	MP0001881_abnormal_mammary_gland	0.80063801
79	MP0000647_abnormal_sebaceous_gland	0.76545676
80	MP0002269_muscular_atrophy	0.76396639
81	MP0003868_abnormal_feces_composition	0.76302714
82	MP0002019_abnormal_tumor_incidence	0.74162292
83	MP0003385_abnormal_body_wall	0.73173170
84	MP0002396_abnormal_hematopoietic_system	0.71956191
85	MP0008775_abnormal_heart_ventricle	0.71168237
86	MP0005187_abnormal_penis_morphology	0.70614099
87	MP0005389_reproductive_system_phenotype	0.69499338
88	MP0003221_abnormal_cardiomyocyte_apopto	0.68897616
89	MP0001529_abnormal_vocalization	0.68176945
90	MP0005220_abnormal_exocrine_pancreas	0.68152974
91	MP0003567_abnormal_fetal_cardiomyocyte	0.62808936
92	MP0005076_abnormal_cell_differentiation	0.54381773
93	MP0003119_abnormal_digestive_system	0.54191045
94	MP0005408_hypopigmentation	0.54053130
95	MP0004019_abnormal_vitamin_homeostasis	0.53801682
96	MP0008770_decreased_survivor_rate	0.52339485
97	MP0003936_abnormal_reproductive_system	0.52257173
98	MP0005501_abnormal_skin_physiology	0.51012992
99	MP0005384_cellular_phenotype	0.50203911
100	MP0009379_abnormal_foot_pigmentation	0.49378590

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cholecystitis (HP:0001082)	7.46853309
2	Abnormal gallbladder physiology (HP:0012438)	7.46853309
3	Reticulocytosis (HP:0001923)	4.88732038
4	Truncus arteriosus (HP:0001660)	4.67851120
5	Premature ovarian failure (HP:0008209)	4.39768540
6	Abnormality of reticulocytes (HP:0004312)	4.28575953
7	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.17893846
8	Hyperthyroidism (HP:0000836)	4.01457392
9	Male infertility (HP:0003251)	3.81796651
10	Polycythemia (HP:0001901)	3.69261431
11	Poikilocytosis (HP:0004447)	3.60609462
12	Abnormal hemoglobin (HP:0011902)	3.59932305
13	Birth length less than 3rd percentile (HP:0003561)	3.49425141
14	Chromsome breakage (HP:0040012)	3.45379956
15	Cholelithiasis (HP:0001081)	3.42436086
16	Ileus (HP:0002595)	3.31951146
17	Cortical dysplasia (HP:0002539)	3.21810380
18	Upper limb muscle weakness (HP:0003484)	3.20095083
19	Abnormality of homocysteine metabolism (HP:0010919)	3.18480414
20	Homocystinuria (HP:0002156)	3.18480414
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.09673317
22	Abnormal gallbladder morphology (HP:0012437)	3.07236475
23	Reticulocytopenia (HP:0001896)	3.01579774
24	Short middle phalanx of the 5th finger (HP:0004220)	2.99533875
25	Ankyloglossia (HP:0010296)	2.96706506
26	Bowel incontinence (HP:0002607)	2.91121461
27	Pallor (HP:0000980)	2.90553457
28	Abnormal large intestine physiology (HP:0012700)	2.86225977
29	Seborrheic dermatitis (HP:0001051)	2.83796714
30	Hypoparathyroidism (HP:0000829)	2.81488241
31	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.77810386
32	Abnormality of the tricuspid valve (HP:0001702)	2.76209403
33	Acanthocytosis (HP:0001927)	2.72675022
34	Peripheral hypomyelination (HP:0007182)	2.71394793
35	Hyperbilirubinemia (HP:0002904)	2.66525438
36	Hypertensive crisis (HP:0100735)	2.63750146
37	Abnormality of glycolysis (HP:0004366)	2.51110361
38	Increased serum pyruvate (HP:0003542)	2.47540883
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.44840656
40	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.43153687
41	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.39765600
42	Acute encephalopathy (HP:0006846)	2.39440475
43	Acute necrotizing encephalopathy (HP:0006965)	2.36488894
44	Abnormality of the gallbladder (HP:0005264)	2.35292844
45	Acute myeloid leukemia (HP:0004808)	2.31713277
46	Papillary thyroid carcinoma (HP:0002895)	2.31531131
47	Abnormality of cells of the erythroid lineage (HP:0012130)	2.17974756
48	Atelectasis (HP:0100750)	2.17605398
49	Abnormality of cochlea (HP:0000375)	2.14329454
50	Macrocytic anemia (HP:0001972)	2.13136662
51	Abnormality of oral frenula (HP:0000190)	2.11265631
52	Small intestinal stenosis (HP:0012848)	2.10517680
53	Duodenal stenosis (HP:0100867)	2.10517680
54	Abnormality of the preputium (HP:0100587)	2.10289593
55	Orthostatic hypotension (HP:0001278)	2.09786665
56	Increased CSF lactate (HP:0002490)	2.08604676
57	Abnormality of lateral ventricle (HP:0030047)	2.05974026
58	Myelodysplasia (HP:0002863)	2.04521994
59	Generalized aminoaciduria (HP:0002909)	2.04461060
60	Abnormal number of erythroid precursors (HP:0012131)	1.99696099
61	Abnormality of chromosome stability (HP:0003220)	1.97284310
62	Cerebral hypomyelination (HP:0006808)	1.97114073
63	Hypokinesia (HP:0002375)	1.96118113
64	Tinnitus (HP:0000360)	1.94357274
65	Renal Fanconi syndrome (HP:0001994)	1.93222009
66	Median cleft lip (HP:0000161)	1.92828642
67	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87420526
68	Respiratory difficulties (HP:0002880)	1.86453280
69	Progressive macrocephaly (HP:0004481)	1.82153885
70	Increased hepatocellular lipid droplets (HP:0006565)	1.81873252
71	Thyroid carcinoma (HP:0002890)	1.81743011
72	Abdominal situs inversus (HP:0003363)	1.81649808
73	Abnormality of abdominal situs (HP:0011620)	1.81649808
74	Degeneration of anterior horn cells (HP:0002398)	1.79572657
75	Abnormality of the anterior horn cell (HP:0006802)	1.79572657
76	Redundant skin (HP:0001582)	1.78128197
77	Increased intramyocellular lipid droplets (HP:0012240)	1.76639103
78	Infertility (HP:0000789)	1.76301016
79	Increased serum lactate (HP:0002151)	1.75989305
80	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.75428372
81	Abnormality of DNA repair (HP:0003254)	1.74375341
82	Sandal gap (HP:0001852)	1.73667328
83	Palpitations (HP:0001962)	1.72731631
84	Limb hypertonia (HP:0002509)	1.72114778
85	Ventricular fibrillation (HP:0001663)	1.71265998
86	Morphological abnormality of the inner ear (HP:0011390)	1.70912252
87	Horseshoe kidney (HP:0000085)	1.70769953
88	Mitochondrial inheritance (HP:0001427)	1.70729428
89	Hypergonadotropic hypogonadism (HP:0000815)	1.69198720
90	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.69142317
91	Dysmetric saccades (HP:0000641)	1.68314575
92	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.67682556
93	Abnormal number of incisors (HP:0011064)	1.66867898
94	Decreased subcutaneous fat (HP:0001002)	1.66839899
95	Cerebral edema (HP:0002181)	1.66219915
96	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.66218135
97	Hypoplasia of the fovea (HP:0007750)	1.66218135
98	Entropion (HP:0000621)	1.65874588
99	Increased nuchal translucency (HP:0010880)	1.65193246
100	Lactic acidosis (HP:0003128)	1.64790755

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TTK	4.12863357
2	EIF2AK1	3.31614038
3	BUB1	3.13978439
4	KSR2	3.09054207
5	STK16	2.82177511
6	CLK1	2.79563843
7	SRPK1	2.77161191
8	RAF1	2.75408313
9	CDC7	2.61601669
10	RIPK4	2.54515532
11	PBK	2.26065521
12	PLK4	2.24559559
13	BMPR2	1.94570090
14	MAP3K8	1.92365154
15	WEE1	1.91997759
16	NTRK3	1.90609029
17	TSSK6	1.86302792
18	CDK12	1.83661724
19	ARAF	1.81578554
20	BRAF	1.80955689
21	MST4	1.80342466
22	EIF2AK3	1.74931788
23	NEK1	1.68676269
24	NME1	1.66623054
25	NME2	1.58448691
26	BRSK2	1.51482190
27	PDK2	1.51044029
28	ZAK	1.49311211
29	TESK2	1.47923463
30	EEF2K	1.47833411
31	MAP3K2	1.45770334
32	KSR1	1.43904149
33	NEK2	1.43676140
34	CHEK2	1.43141747
35	IRAK3	1.38997827
36	CCNB1	1.36774565
37	PLK1	1.35833382
38	PLK3	1.32260433
39	AURKA	1.29584521
40	TNIK	1.21102472
41	BRSK1	1.20452801
42	STK3	1.15531548
43	STK4	1.15014698
44	ICK	1.10246069
45	PAK1	1.05970128
46	CHEK1	1.05117926
47	BMX	1.04216388
48	WNK4	0.99367025
49	AURKB	0.95764764
50	TAOK3	0.90445054
51	ATR	0.89352459
52	RPS6KB2	0.88961982
53	ILK	0.84347143
54	ATM	0.83239253
55	MARK3	0.82419691
56	SCYL2	0.79635893
57	PIK3CG	0.78701643
58	CDK1	0.77830203
59	RPS6KA5	0.74959011
60	VRK1	0.71702376
61	CDK2	0.70287834
62	CDK7	0.68802920
63	WNK1	0.68446602
64	DYRK3	0.65007041
65	CSNK2A2	0.63495827
66	MAP3K13	0.57396330
67	TEC	0.56417004
68	RET	0.55347861
69	MAP3K9	0.55009274
70	LATS2	0.53806349
71	NEK6	0.52359442
72	MOS	0.50682653
73	MAP3K4	0.50657514
74	CSNK1E	0.49956309
75	PIM1	0.49792763
76	AKT2	0.47853127
77	CSNK2A1	0.47521014
78	MTOR	0.47409631
79	PKN1	0.46431445
80	CDK11A	0.45389655
81	TAOK2	0.44412857
82	STK10	0.42694494
83	JAK3	0.39847202
84	MAP2K1	0.39173122
85	MAPKAPK3	0.38769358
86	PAK2	0.37734166
87	PAK4	0.37282104
88	CDK14	0.36931565
89	DMPK	0.34716363
90	LRRK2	0.34679688
91	CDK15	0.34479392
92	LATS1	0.34420236
93	JAK2	0.31634909
94	PRKCI	0.30893763
95	NTRK1	0.29968132
96	CDK18	0.29864073
97	BRD4	0.29138431
98	PLK2	0.29013904
99	CDK8	0.28718503
100	ALK	0.27582875

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	3.72099700
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.46275139
3	DNA replication_Homo sapiens_hsa03030	3.37853629
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.27409530
5	Ribosome_Homo sapiens_hsa03010	2.92019912
6	Homologous recombination_Homo sapiens_hsa03440	2.80341552
7	Basal transcription factors_Homo sapiens_hsa03022	2.73470092
8	RNA transport_Homo sapiens_hsa03013	2.68446729
9	Proteasome_Homo sapiens_hsa03050	2.50455869
10	One carbon pool by folate_Homo sapiens_hsa00670	2.45901667
11	Cell cycle_Homo sapiens_hsa04110	2.44737850
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.35126614
13	RNA polymerase_Homo sapiens_hsa03020	2.21067149
14	Spliceosome_Homo sapiens_hsa03040	2.15836206
15	Nucleotide excision repair_Homo sapiens_hsa03420	2.15276546
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.07165054
17	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.04039476
18	Base excision repair_Homo sapiens_hsa03410	1.94424570
19	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.91423131
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86073472
21	Parkinsons disease_Homo sapiens_hsa05012	1.79811015
22	RNA degradation_Homo sapiens_hsa03018	1.73391056
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.64973054
24	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.57448725
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.57305891
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.56108925
27	Oocyte meiosis_Homo sapiens_hsa04114	1.52637658
28	Huntingtons disease_Homo sapiens_hsa05016	1.51957301
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.48002002
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.44102642
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.41998398
32	Carbon metabolism_Homo sapiens_hsa01200	1.37447817
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33116537
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28909574
35	Purine metabolism_Homo sapiens_hsa00230	1.22084392
36	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.19615708
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.07401970
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.05600944
39	Pentose phosphate pathway_Homo sapiens_hsa00030	1.05174581
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.03689477
41	Arginine biosynthesis_Homo sapiens_hsa00220	1.00275246
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.99419613
43	Sulfur relay system_Homo sapiens_hsa04122	0.98298226
44	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.93658437
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.92065696
46	Olfactory transduction_Homo sapiens_hsa04740	0.91806681
47	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.90900752
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86283214
49	Protein export_Homo sapiens_hsa03060	0.85979009
50	Alzheimers disease_Homo sapiens_hsa05010	0.81586374
51	Fatty acid elongation_Homo sapiens_hsa00062	0.79777247
52	Thyroid cancer_Homo sapiens_hsa05216	0.79498923
53	Acute myeloid leukemia_Homo sapiens_hsa05221	0.79434469
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76012113
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75761491
56	Glutathione metabolism_Homo sapiens_hsa00480	0.73678924
57	Propanoate metabolism_Homo sapiens_hsa00640	0.73492026
58	Viral carcinogenesis_Homo sapiens_hsa05203	0.65524463
59	p53 signaling pathway_Homo sapiens_hsa04115	0.64605878
60	Sulfur metabolism_Homo sapiens_hsa00920	0.64554155
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62546260
62	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.62030335
63	Metabolic pathways_Homo sapiens_hsa01100	0.59019614
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.57967520
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56812249
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55976737
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55444745
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54165873
69	mTOR signaling pathway_Homo sapiens_hsa04150	0.49997851
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49811515
71	Retinol metabolism_Homo sapiens_hsa00830	0.49404758
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.45500743
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42568490
74	Folate biosynthesis_Homo sapiens_hsa00790	0.41118761
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.37716626
76	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.36895076
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.36532283
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.32640439
79	Alcoholism_Homo sapiens_hsa05034	0.32431602
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.30528291
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27766840
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.26528766
83	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.25945684
84	Prion diseases_Homo sapiens_hsa05020	0.25323102
85	Cardiac muscle contraction_Homo sapiens_hsa04260	0.24052019
86	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23628221
87	Butanoate metabolism_Homo sapiens_hsa00650	0.22660019
88	Apoptosis_Homo sapiens_hsa04210	0.22450615
89	Insulin signaling pathway_Homo sapiens_hsa04910	0.21419129
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.19913701
91	Gap junction_Homo sapiens_hsa04540	0.18681190
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.17265250
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.15053552
94	Pancreatic cancer_Homo sapiens_hsa05212	0.12864998
95	Caffeine metabolism_Homo sapiens_hsa00232	0.10360329
96	Bile secretion_Homo sapiens_hsa04976	0.09645429
97	VEGF signaling pathway_Homo sapiens_hsa04370	0.08122000
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.07781773
99	Galactose metabolism_Homo sapiens_hsa00052	0.06846462
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.06793362

VENTXP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »