VENTXP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.42459109
2L-fucose catabolic process (GO:0042355)4.58472456
3fucose catabolic process (GO:0019317)4.58472456
4L-fucose metabolic process (GO:0042354)4.58472456
5response to pheromone (GO:0019236)4.38868511
6DNA deamination (GO:0045006)4.13194920
7cellular ketone body metabolic process (GO:0046950)4.11683899
8tryptophan catabolic process (GO:0006569)3.77996019
9indole-containing compound catabolic process (GO:0042436)3.77996019
10indolalkylamine catabolic process (GO:0046218)3.77996019
11water-soluble vitamin biosynthetic process (GO:0042364)3.77664478
12negative regulation of telomere maintenance (GO:0032205)3.76489953
13ketone body metabolic process (GO:1902224)3.68654489
14detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60023017
15indolalkylamine metabolic process (GO:0006586)3.57645823
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51356533
17platelet dense granule organization (GO:0060155)3.50912336
18kynurenine metabolic process (GO:0070189)3.30792121
19cornea development in camera-type eye (GO:0061303)3.29014448
20regulation of hexokinase activity (GO:1903299)3.25429257
21regulation of glucokinase activity (GO:0033131)3.25429257
22protein polyglutamylation (GO:0018095)3.22812598
23detection of light stimulus involved in visual perception (GO:0050908)3.20959705
24detection of light stimulus involved in sensory perception (GO:0050962)3.20959705
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.20430463
26protein complex biogenesis (GO:0070271)3.19121798
27epithelial cilium movement (GO:0003351)3.18756915
28tryptophan metabolic process (GO:0006568)3.18461104
29neural tube formation (GO:0001841)3.17612453
30piRNA metabolic process (GO:0034587)3.14627169
31kidney morphogenesis (GO:0060993)3.14169397
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10383343
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.10383343
34NADH dehydrogenase complex assembly (GO:0010257)3.10383343
35axoneme assembly (GO:0035082)3.00821805
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.00426200
37neuronal action potential (GO:0019228)2.97522318
38regulation of cilium movement (GO:0003352)2.95496961
39mitochondrial respiratory chain complex assembly (GO:0033108)2.95190662
40cellular biogenic amine catabolic process (GO:0042402)2.94389603
41amine catabolic process (GO:0009310)2.94389603
42nephron epithelium morphogenesis (GO:0072088)2.92687075
43nephron tubule morphogenesis (GO:0072078)2.92687075
44synaptic transmission, cholinergic (GO:0007271)2.90925858
45regulation of gene silencing by RNA (GO:0060966)2.90877538
46regulation of posttranscriptional gene silencing (GO:0060147)2.90877538
47regulation of gene silencing by miRNA (GO:0060964)2.90877538
48ubiquinone biosynthetic process (GO:0006744)2.86296642
49indole-containing compound metabolic process (GO:0042430)2.81332491
50preassembly of GPI anchor in ER membrane (GO:0016254)2.80563152
51regulation of rhodopsin mediated signaling pathway (GO:0022400)2.80303736
52behavioral response to ethanol (GO:0048149)2.79620181
53regulation of action potential (GO:0098900)2.79023987
54primary amino compound metabolic process (GO:1901160)2.77562222
55ubiquinone metabolic process (GO:0006743)2.73346659
56rhodopsin mediated signaling pathway (GO:0016056)2.72921420
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63088628
58negative regulation of translation, ncRNA-mediated (GO:0040033)2.63088628
59regulation of translation, ncRNA-mediated (GO:0045974)2.63088628
60cilium morphogenesis (GO:0060271)2.62648674
61protein-cofactor linkage (GO:0018065)2.61901774
62male meiosis (GO:0007140)2.61815051
63pyrimidine nucleobase catabolic process (GO:0006208)2.60664642
64energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57393435
65ATP synthesis coupled proton transport (GO:0015986)2.57393435
66regulation of telomere maintenance (GO:0032204)2.57023084
67auditory receptor cell stereocilium organization (GO:0060088)2.54878861
68somite rostral/caudal axis specification (GO:0032525)2.53688669
69cAMP catabolic process (GO:0006198)2.53248753
70negative regulation of mast cell activation (GO:0033004)2.52996800
71cilium or flagellum-dependent cell motility (GO:0001539)2.52698856
72replication fork processing (GO:0031297)2.52339207
73positive regulation of fatty acid transport (GO:2000193)2.52276629
74renal tubule morphogenesis (GO:0061333)2.51801039
75cilium movement (GO:0003341)2.51707296
76S-adenosylmethionine metabolic process (GO:0046500)2.50754777
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49563711
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49563711
79gamma-aminobutyric acid transport (GO:0015812)2.48350790
80sulfation (GO:0051923)2.48336711
81multicellular organism reproduction (GO:0032504)2.47805842
82inositol phosphate catabolic process (GO:0071545)2.47386377
83protein localization to cilium (GO:0061512)2.47352678
84phosphatidylinositol acyl-chain remodeling (GO:0036149)2.47256321
85thyroid hormone metabolic process (GO:0042403)2.46989975
86nonmotile primary cilium assembly (GO:0035058)2.46364720
87negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46014709
88pseudouridine synthesis (GO:0001522)2.45811311
89retinal cone cell development (GO:0046549)2.45557500
90positive regulation of defense response to virus by host (GO:0002230)2.45497187
91photoreceptor cell maintenance (GO:0045494)2.45451791
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45166669
93DNA methylation involved in gamete generation (GO:0043046)2.44730757
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44660255
95startle response (GO:0001964)2.43953697
96reflex (GO:0060004)2.42870824
97respiratory chain complex IV assembly (GO:0008535)2.42780848
98positive regulation of meiosis (GO:0045836)2.42509139
99neurofilament cytoskeleton organization (GO:0060052)2.41786831
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41173375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.88876748
2VDR_22108803_ChIP-Seq_LS180_Human3.43243404
3EZH2_22144423_ChIP-Seq_EOC_Human3.00377438
4GBX2_23144817_ChIP-Seq_PC3_Human2.96424283
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61970314
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52123714
7IGF1R_20145208_ChIP-Seq_DFB_Human2.51914670
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20989221
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.18698124
10TAF15_26573619_Chip-Seq_HEK293_Human2.14374440
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12771133
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09361722
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.09231687
14EWS_26573619_Chip-Seq_HEK293_Human2.08227751
15FUS_26573619_Chip-Seq_HEK293_Human2.08194782
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07175053
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01351681
18P300_19829295_ChIP-Seq_ESCs_Human1.88373783
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77381930
20ER_23166858_ChIP-Seq_MCF-7_Human1.75887152
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73874170
22IRF1_19129219_ChIP-ChIP_H3396_Human1.65185146
23TP53_22573176_ChIP-Seq_HFKS_Human1.62766957
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61775247
25BCAT_22108803_ChIP-Seq_LS180_Human1.55181085
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54992337
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54743530
28CBP_20019798_ChIP-Seq_JUKART_Human1.54743530
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53271342
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49560667
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48267492
32REST_21632747_ChIP-Seq_MESCs_Mouse1.47785331
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45886300
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44219283
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.43818703
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.43428965
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42844849
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41490459
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.41056040
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40583861
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40583861
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.40253979
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39733874
44SMAD4_21799915_ChIP-Seq_A2780_Human1.36860882
45AR_25329375_ChIP-Seq_VCAP_Human1.36643652
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36440436
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35147937
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33726337
49RNF2_27304074_Chip-Seq_NSC_Mouse1.33233998
50TCF4_23295773_ChIP-Seq_U87_Human1.32901626
51STAT3_23295773_ChIP-Seq_U87_Human1.32728766
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31064295
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.31064295
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30620435
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30039871
56TCF4_22108803_ChIP-Seq_LS180_Human1.29648615
57MYC_18940864_ChIP-ChIP_HL60_Human1.29617248
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29236942
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29041890
60NANOG_19829295_ChIP-Seq_ESCs_Human1.28893041
61SOX2_19829295_ChIP-Seq_ESCs_Human1.28893041
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28586296
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.27346442
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27213361
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25842303
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.24175250
67RUNX2_22187159_ChIP-Seq_PCA_Human1.23543828
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.22940363
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20255962
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.20155715
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20120265
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18078213
73AR_20517297_ChIP-Seq_VCAP_Human1.18075454
74NCOR_22424771_ChIP-Seq_293T_Human1.16066808
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.14674291
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14206211
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13146052
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12978633
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10372673
80HOXB7_26014856_ChIP-Seq_BT474_Human1.09195110
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08929701
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08898506
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08268275
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.08155551
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.07628072
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06631407
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.06484171
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.06399802
89P53_22387025_ChIP-Seq_ESCs_Mouse1.06042015
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.05143767
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03878958
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03680622
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03636426
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02549556
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00851100
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.00522788
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98225054
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98120574
99MYC_19829295_ChIP-Seq_ESCs_Human0.97543706
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.97476307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.77084494
2MP0003195_calcinosis2.70344751
3MP0001968_abnormal_touch/_nociception2.67601065
4MP0003787_abnormal_imprinting2.53470030
5MP0002876_abnormal_thyroid_physiology2.35131146
6MP0005551_abnormal_eye_electrophysiolog2.34059324
7MP0001986_abnormal_taste_sensitivity2.24687336
8MP0002102_abnormal_ear_morphology2.19266846
9MP0002736_abnormal_nociception_after2.18906901
10MP0004885_abnormal_endolymph2.17651570
11MP0006292_abnormal_olfactory_placode2.14081355
12MP0002837_dystrophic_cardiac_calcinosis2.13180325
13MP0006072_abnormal_retinal_apoptosis2.11212960
14MP0008875_abnormal_xenobiotic_pharmacok2.08008802
15MP0003011_delayed_dark_adaptation2.03918098
16MP0008995_early_reproductive_senescence2.01845112
17MP0005084_abnormal_gallbladder_morpholo1.94179679
18MP0002138_abnormal_hepatobiliary_system1.90062549
19MP0003880_abnormal_central_pattern1.87643658
20MP0002638_abnormal_pupillary_reflex1.85985932
21MP0000569_abnormal_digit_pigmentation1.85888424
22MP0009745_abnormal_behavioral_response1.81749265
23MP0003136_yellow_coat_color1.80679340
24MP0008872_abnormal_physiological_respon1.80105567
25MP0005645_abnormal_hypothalamus_physiol1.78238778
26MP0003646_muscle_fatigue1.75483987
27MP0004133_heterotaxia1.73342844
28MP0002272_abnormal_nervous_system1.70956280
29MP0009046_muscle_twitch1.69786130
30MP0006276_abnormal_autonomic_nervous1.69197029
31MP0000427_abnormal_hair_cycle1.68569401
32MP0004043_abnormal_pH_regulation1.67604592
33MP0000372_irregular_coat_pigmentation1.66449279
34MP0005253_abnormal_eye_physiology1.66432319
35MP0004142_abnormal_muscle_tone1.65881615
36MP0002653_abnormal_ependyma_morphology1.65716350
37MP0005646_abnormal_pituitary_gland1.61613578
38MP0004147_increased_porphyrin_level1.55797665
39MP0001501_abnormal_sleep_pattern1.54142050
40MP0010386_abnormal_urinary_bladder1.40910401
41MP0002735_abnormal_chemical_nociception1.37505814
42MP0002163_abnormal_gland_morphology1.33868083
43MP0001486_abnormal_startle_reflex1.32606334
44MP0005174_abnormal_tail_pigmentation1.32170028
45MP0004145_abnormal_muscle_electrophysio1.30559436
46MP0002557_abnormal_social/conspecific_i1.29667498
47MP0002938_white_spotting1.28787625
48MP0001984_abnormal_olfaction1.28492474
49MP0002064_seizures1.27840705
50MP0002572_abnormal_emotion/affect_behav1.27464326
51MP0002733_abnormal_thermal_nociception1.27447879
52MP0005379_endocrine/exocrine_gland_phen1.26721418
53MP0000631_abnormal_neuroendocrine_gland1.26512292
54MP0001485_abnormal_pinna_reflex1.26246224
55MP0001970_abnormal_pain_threshold1.23733174
56MP0002160_abnormal_reproductive_system1.23415781
57MP0005389_reproductive_system_phenotype1.23270989
58MP0001529_abnormal_vocalization1.20273470
59MP0002928_abnormal_bile_duct1.20208110
60MP0004742_abnormal_vestibular_system1.12634707
61MP0005386_behavior/neurological_phenoty1.07315392
62MP0004924_abnormal_behavior1.07315392
63MP0003122_maternal_imprinting1.07000580
64MP0003121_genomic_imprinting1.06054802
65MP0003635_abnormal_synaptic_transmissio1.05102373
66MP0001188_hyperpigmentation1.04940745
67MP0001905_abnormal_dopamine_level1.04147948
68MP0003283_abnormal_digestive_organ1.03354199
69MP0001919_abnormal_reproductive_system1.01711109
70MP0005671_abnormal_response_to1.01274892
71MP0005195_abnormal_posterior_eye1.00024320
72MP0002234_abnormal_pharynx_morphology0.99897929
73MP0003252_abnormal_bile_duct0.99639306
74MP0002277_abnormal_respiratory_mucosa0.98768128
75MP0002067_abnormal_sensory_capabilities0.98382892
76MP0002063_abnormal_learning/memory/cond0.95930635
77MP0005085_abnormal_gallbladder_physiolo0.95818780
78MP0002734_abnormal_mechanical_nocicepti0.95271935
79MP0003718_maternal_effect0.91178782
80MP0005410_abnormal_fertilization0.88589604
81MP0005332_abnormal_amino_acid0.86137258
82MP0002751_abnormal_autonomic_nervous0.83897432
83MP0002184_abnormal_innervation0.83790382
84MP0000538_abnormal_urinary_bladder0.83617316
85MP0002752_abnormal_somatic_nervous0.83340911
86MP0000230_abnormal_systemic_arterial0.83248832
87MP0000383_abnormal_hair_follicle0.83113376
88MP0000778_abnormal_nervous_system0.83050985
89MP0005423_abnormal_somatic_nervous0.81854262
90MP0001440_abnormal_grooming_behavior0.79799824
91MP0002254_reproductive_system_inflammat0.79734018
92MP0002095_abnormal_skin_pigmentation0.79456445
93MP0003786_premature_aging0.75838043
94MP0001502_abnormal_circadian_rhythm0.74588577
95MP0005075_abnormal_melanosome_morpholog0.74424728
96MP0000026_abnormal_inner_ear0.74182367
97MP0005167_abnormal_blood-brain_barrier0.74083092
98MP0002229_neurodegeneration0.74016706
99MP0003698_abnormal_male_reproductive0.73315159
100MP0002210_abnormal_sex_determination0.72330605

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.34174530
2Pancreatic cysts (HP:0001737)4.13562561
3Abnormality of midbrain morphology (HP:0002418)4.00883257
4Molar tooth sign on MRI (HP:0002419)4.00883257
5Pancreatic fibrosis (HP:0100732)3.93765957
6True hermaphroditism (HP:0010459)3.70803166
7Nephronophthisis (HP:0000090)3.61619807
8Type II lissencephaly (HP:0007260)3.34016229
9Abnormality of the renal cortex (HP:0011035)3.22513367
10Chronic hepatic failure (HP:0100626)3.08310251
11Abnormality of the renal medulla (HP:0100957)3.07679828
12Abnormal rod and cone electroretinograms (HP:0008323)2.91637290
13Attenuation of retinal blood vessels (HP:0007843)2.80542958
14Tubular atrophy (HP:0000092)2.73373917
15Renal cortical cysts (HP:0000803)2.70531477
16Medial flaring of the eyebrow (HP:0010747)2.63272914
17Polydipsia (HP:0001959)2.60388208
18Abnormal drinking behavior (HP:0030082)2.60388208
19Inability to walk (HP:0002540)2.50944390
20Abolished electroretinogram (ERG) (HP:0000550)2.49823216
21Cystic liver disease (HP:0006706)2.48882970
22Abnormality of the renal collecting system (HP:0004742)2.47341449
23Acute necrotizing encephalopathy (HP:0006965)2.46595879
24Duplicated collecting system (HP:0000081)2.46097030
25Pendular nystagmus (HP:0012043)2.45257286
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44515442
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40345409
28Decreased central vision (HP:0007663)2.38439559
29Sclerocornea (HP:0000647)2.36798802
30Pachygyria (HP:0001302)2.35924131
31Lissencephaly (HP:0001339)2.34281118
32Large for gestational age (HP:0001520)2.33533221
33Methylmalonic acidemia (HP:0002912)2.30543163
34Increased CSF lactate (HP:0002490)2.28268541
35Progressive inability to walk (HP:0002505)2.26958130
36Mitochondrial inheritance (HP:0001427)2.24290666
37Progressive macrocephaly (HP:0004481)2.22427028
38Hyperventilation (HP:0002883)2.20780265
39Lipid accumulation in hepatocytes (HP:0006561)2.19632586
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.17716903
41Keratoconus (HP:0000563)2.15232535
42Increased corneal curvature (HP:0100692)2.15232535
43Abnormality of the pons (HP:0007361)2.14470246
44Abnormality of alanine metabolism (HP:0010916)2.13670685
45Hyperalaninemia (HP:0003348)2.13670685
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13670685
47Cerebellar dysplasia (HP:0007033)2.11780062
48Congenital hepatic fibrosis (HP:0002612)2.10916267
49Congenital, generalized hypertrichosis (HP:0004540)2.10835387
50Acute encephalopathy (HP:0006846)2.09454833
51Concave nail (HP:0001598)2.07840823
52Hemiparesis (HP:0001269)2.07371532
53Hypoplasia of the pons (HP:0012110)2.06544772
54Male pseudohermaphroditism (HP:0000037)2.03775124
55Increased hepatocellular lipid droplets (HP:0006565)2.02240504
56Polyuria (HP:0000103)2.02098747
57Optic disc pallor (HP:0000543)2.02065268
58Bile duct proliferation (HP:0001408)2.00431018
59Abnormal biliary tract physiology (HP:0012439)2.00431018
60Severe muscular hypotonia (HP:0006829)1.99332977
61Aplasia/Hypoplasia of the spleen (HP:0010451)1.98933374
62Anencephaly (HP:0002323)1.97514079
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.97436333
64Stomach cancer (HP:0012126)1.96863849
65Abnormal mitochondria in muscle tissue (HP:0008316)1.96775403
66Hypothermia (HP:0002045)1.96516117
67Methylmalonic aciduria (HP:0012120)1.96163834
68Furrowed tongue (HP:0000221)1.95940264
69Retinal dysplasia (HP:0007973)1.93567748
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91646087
71Decreased circulating renin level (HP:0003351)1.91382594
72Gaze-evoked nystagmus (HP:0000640)1.90995617
733-Methylglutaconic aciduria (HP:0003535)1.88928592
74Gait imbalance (HP:0002141)1.88024196
75Agitation (HP:0000713)1.87706678
76Asplenia (HP:0001746)1.87173168
77Thyroid-stimulating hormone excess (HP:0002925)1.85647299
78Bony spicule pigmentary retinopathy (HP:0007737)1.85380355
79Abnormality of DNA repair (HP:0003254)1.85338633
80Broad-based gait (HP:0002136)1.84160500
81Aplasia/hypoplasia of the uterus (HP:0008684)1.84135075
82Short tibia (HP:0005736)1.84115068
83Febrile seizures (HP:0002373)1.83789638
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.82671673
85Absent/shortened dynein arms (HP:0200106)1.82671673
86Postaxial foot polydactyly (HP:0001830)1.81997755
87Abnormal respiratory epithelium morphology (HP:0012253)1.79404813
88Abnormal respiratory motile cilium morphology (HP:0005938)1.79404813
89Constricted visual fields (HP:0001133)1.78911458
90Intestinal atresia (HP:0011100)1.78761952
91Ketosis (HP:0001946)1.78499601
92Congenital primary aphakia (HP:0007707)1.77626047
93Renal Fanconi syndrome (HP:0001994)1.75586367
94Absent thumb (HP:0009777)1.74153500
95Optic nerve hypoplasia (HP:0000609)1.73081042
96Abnormal albumin level (HP:0012116)1.71964458
97Hypoalbuminemia (HP:0003073)1.71964458
98Nephrogenic diabetes insipidus (HP:0009806)1.71155905
99Disproportionate short-trunk short stature (HP:0003521)1.70433861
100Stomatitis (HP:0010280)1.69393796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72535450
2TAOK33.98018109
3ADRBK23.27367058
4BMPR1B2.88477408
5TXK2.86920379
6GRK12.70761764
7MAP4K22.65556384
8WNK42.61087426
9TLK12.48070634
10ZAK2.37703132
11CASK2.35065406
12WNK32.16983585
13NUAK12.05430145
14PINK11.93827651
15MAPK131.85694565
16ACVR1B1.73371331
17INSRR1.70000310
18TNIK1.58398716
19STK391.57688844
20OXSR11.55703579
21DAPK21.50761288
22TAF11.45910274
23MAP3K41.37810971
24STK161.37691910
25BCKDK1.33759044
26TRIM281.32005889
27DYRK21.21787281
28PNCK1.21388994
29MKNK21.17442172
30MAP4K11.09462976
31VRK11.08473964
32ADRBK11.05608491
33TGFBR11.05596791
34PAK31.04594898
35MAP2K71.01959682
36PRKCE1.01516406
37PHKG20.99095243
38PHKG10.99095243
39PLK20.95059614
40TIE10.93836504
41MUSK0.91086585
42PRKCG0.89595141
43MARK10.89325485
44TEC0.86738457
45AKT30.86611219
46MAP2K60.83246817
47CAMKK20.80796075
48STK38L0.79832953
49PRKCQ0.79490682
50EPHA40.77679702
51NTRK30.76225364
52MAPKAPK30.75102598
53VRK20.67722848
54EIF2AK30.66060397
55MAPK150.65785362
56ITK0.63675883
57NLK0.62095817
58MAPKAPK50.59646208
59IRAK40.58819321
60IRAK10.58795132
61ERBB30.58154620
62CSNK1G20.57310284
63CSNK1G10.57301995
64RPS6KA50.56237001
65PLK30.55681299
66IKBKB0.54501413
67PIK3CA0.54120974
68MST40.52589015
69MKNK10.52272549
70PRKCI0.51327917
71CAMK2A0.51137193
72PRKACA0.47841497
73PTK2B0.47119592
74CSNK1G30.47087824
75FGFR20.46198445
76PKN10.43957623
77CSNK1A10.42533314
78SGK20.41299909
79BCR0.39803500
80CAMK10.39151792
81SIK20.38765585
82TSSK60.38259255
83LIMK10.37757098
84PLK40.37404074
85STK30.36638870
86SYK0.36239810
87MARK30.34437321
88STK110.34116285
89PRKG10.32885152
90PRKCA0.31843049
91MAP2K40.30756984
92PRKCZ0.30666096
93EPHA30.30354035
94DYRK1A0.29745220
95NTRK20.29545510
96CHUK0.28864818
97WEE10.26285830
98OBSCN0.25532352
99IGF1R0.25415352
100SGK2230.24744094

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.83882250
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.78412125
3Linoleic acid metabolism_Homo sapiens_hsa005912.68708801
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61140926
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.51878181
6Butanoate metabolism_Homo sapiens_hsa006502.49937581
7Oxidative phosphorylation_Homo sapiens_hsa001902.44709929
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.30622303
9Nitrogen metabolism_Homo sapiens_hsa009102.19112526
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15198253
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96976490
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95440831
13Nicotine addiction_Homo sapiens_hsa050331.93262965
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88940339
15Parkinsons disease_Homo sapiens_hsa050121.84843329
16Ether lipid metabolism_Homo sapiens_hsa005651.76294770
17Protein export_Homo sapiens_hsa030601.75774845
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74956001
19Tryptophan metabolism_Homo sapiens_hsa003801.68640897
20Caffeine metabolism_Homo sapiens_hsa002321.68530232
21Selenocompound metabolism_Homo sapiens_hsa004501.66497887
22Basal transcription factors_Homo sapiens_hsa030221.55582719
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.49883524
24RNA polymerase_Homo sapiens_hsa030201.44212371
25Olfactory transduction_Homo sapiens_hsa047401.41627410
26Homologous recombination_Homo sapiens_hsa034401.36115390
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.35046490
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30137362
29Propanoate metabolism_Homo sapiens_hsa006401.29538974
30Morphine addiction_Homo sapiens_hsa050321.28329466
31Taste transduction_Homo sapiens_hsa047421.24344298
32Peroxisome_Homo sapiens_hsa041461.21054458
33Fanconi anemia pathway_Homo sapiens_hsa034601.20982476
34Alzheimers disease_Homo sapiens_hsa050101.18882386
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18865648
36Huntingtons disease_Homo sapiens_hsa050161.16803044
37Cardiac muscle contraction_Homo sapiens_hsa042601.11771404
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.11643845
39Regulation of autophagy_Homo sapiens_hsa041401.11518342
40Arachidonic acid metabolism_Homo sapiens_hsa005901.09709103
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08661038
42Insulin secretion_Homo sapiens_hsa049111.04823949
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04677931
44Circadian entrainment_Homo sapiens_hsa047131.04362584
45Chemical carcinogenesis_Homo sapiens_hsa052041.04190863
46Sulfur metabolism_Homo sapiens_hsa009201.03221035
47Retinol metabolism_Homo sapiens_hsa008301.00919141
48RNA degradation_Homo sapiens_hsa030181.00592884
49Glutamatergic synapse_Homo sapiens_hsa047240.96471905
50Asthma_Homo sapiens_hsa053100.96255151
51ABC transporters_Homo sapiens_hsa020100.96144135
52Collecting duct acid secretion_Homo sapiens_hsa049660.95472702
53GABAergic synapse_Homo sapiens_hsa047270.94616516
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94300401
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93123191
56Type I diabetes mellitus_Homo sapiens_hsa049400.92147640
57Serotonergic synapse_Homo sapiens_hsa047260.91962412
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91671663
59Fat digestion and absorption_Homo sapiens_hsa049750.85911625
60Ovarian steroidogenesis_Homo sapiens_hsa049130.84102801
61One carbon pool by folate_Homo sapiens_hsa006700.83928814
62Primary immunodeficiency_Homo sapiens_hsa053400.80547431
63Proteasome_Homo sapiens_hsa030500.79552683
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78428843
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77225787
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74827887
67Salivary secretion_Homo sapiens_hsa049700.74105744
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71239630
69Steroid biosynthesis_Homo sapiens_hsa001000.70577311
70Purine metabolism_Homo sapiens_hsa002300.69528688
71Graft-versus-host disease_Homo sapiens_hsa053320.67057783
72Vitamin digestion and absorption_Homo sapiens_hsa049770.66372445
73Allograft rejection_Homo sapiens_hsa053300.65633585
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65066398
75Autoimmune thyroid disease_Homo sapiens_hsa053200.64845297
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62293376
77Metabolic pathways_Homo sapiens_hsa011000.61309027
78Calcium signaling pathway_Homo sapiens_hsa040200.60974204
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60788817
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60456259
81Long-term depression_Homo sapiens_hsa047300.59647307
82Fatty acid elongation_Homo sapiens_hsa000620.55093163
83Dopaminergic synapse_Homo sapiens_hsa047280.55090401
84beta-Alanine metabolism_Homo sapiens_hsa004100.54387658
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54128534
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52150388
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50894734
88Dorso-ventral axis formation_Homo sapiens_hsa043200.47944079
89Ribosome_Homo sapiens_hsa030100.45538983
90Glycerolipid metabolism_Homo sapiens_hsa005610.44788515
91Rheumatoid arthritis_Homo sapiens_hsa053230.43249377
92Hedgehog signaling pathway_Homo sapiens_hsa043400.42677677
93Cocaine addiction_Homo sapiens_hsa050300.42456257
94Fatty acid degradation_Homo sapiens_hsa000710.39427284
95Fatty acid metabolism_Homo sapiens_hsa012120.39304005
96Pyrimidine metabolism_Homo sapiens_hsa002400.37921788
97Mineral absorption_Homo sapiens_hsa049780.37717721
98Amphetamine addiction_Homo sapiens_hsa050310.33350375
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.30849618
100Sulfur relay system_Homo sapiens_hsa041220.30698879

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