VEZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)4.14794730
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.92868822
3definitive hemopoiesis (GO:0060216)3.91129652
4microtubule depolymerization (GO:0007019)3.90043249
5forebrain neuron differentiation (GO:0021879)3.82363183
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.78762294
7pyrimidine nucleobase catabolic process (GO:0006208)3.72262858
8otic vesicle formation (GO:0030916)3.66946985
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61090407
10neuronal stem cell maintenance (GO:0097150)3.55084506
11intraciliary transport (GO:0042073)3.48826514
12olfactory bulb development (GO:0021772)3.44003030
13ganglion development (GO:0061548)3.41530957
14epithelial cilium movement (GO:0003351)3.35230149
15neural tube formation (GO:0001841)3.34975373
16axonal fasciculation (GO:0007413)3.34735640
17regulation of growth hormone secretion (GO:0060123)3.28725329
18type B pancreatic cell development (GO:0003323)3.28613009
19presynaptic membrane assembly (GO:0097105)3.25166195
20paraxial mesoderm development (GO:0048339)3.23835128
21cerebral cortex radially oriented cell migration (GO:0021799)3.22300815
22negative regulation of oligodendrocyte differentiation (GO:0048715)3.13737931
23mitotic cytokinesis (GO:0000281)3.11267412
24cilium movement (GO:0003341)3.07443301
25lateral sprouting from an epithelium (GO:0060601)3.07205722
26positive regulation of histone deacetylation (GO:0031065)3.06612240
27cell proliferation in forebrain (GO:0021846)3.05796464
28photoreceptor cell differentiation (GO:0046530)3.03211601
29eye photoreceptor cell differentiation (GO:0001754)3.03211601
30centriole replication (GO:0007099)3.02725442
31cytoskeleton-dependent cytokinesis (GO:0061640)2.99340900
32regulation of oligodendrocyte differentiation (GO:0048713)2.99099347
33establishment of nucleus localization (GO:0040023)2.98669009
34positive regulation of mRNA processing (GO:0050685)2.97829210
35positive regulation of hormone biosynthetic process (GO:0046886)2.96730840
36axonemal dynein complex assembly (GO:0070286)2.92711382
37postsynaptic membrane organization (GO:0001941)2.91623972
38central nervous system projection neuron axonogenesis (GO:0021952)2.91362281
39embryonic retina morphogenesis in camera-type eye (GO:0060059)2.90940073
40positive regulation of neuroblast proliferation (GO:0002052)2.90386986
41neuron recognition (GO:0008038)2.89566271
42retinal ganglion cell axon guidance (GO:0031290)2.89138371
43nonmotile primary cilium assembly (GO:0035058)2.88181961
44neuron projection extension involved in neuron projection guidance (GO:1902284)2.87865303
45axon extension involved in axon guidance (GO:0048846)2.87865303
46limb development (GO:0060173)2.86174273
47appendage development (GO:0048736)2.86174273
48glandular epithelial cell development (GO:0002068)2.84441706
49embryonic camera-type eye morphogenesis (GO:0048596)2.83358928
50cytoplasmic mRNA processing body assembly (GO:0033962)2.82643695
51behavioral response to nicotine (GO:0035095)2.80875894
52regulation of development, heterochronic (GO:0040034)2.80151730
53mitotic sister chromatid cohesion (GO:0007064)2.80063724
54positive regulation of mRNA 3-end processing (GO:0031442)2.78573829
55presynaptic membrane organization (GO:0097090)2.77340712
56neuron fate determination (GO:0048664)2.73754791
57regulation of non-canonical Wnt signaling pathway (GO:2000050)2.72750283
58positive regulation of embryonic development (GO:0040019)2.71290641
59regulation of cardioblast proliferation (GO:0003264)2.70548777
60regulation of secondary heart field cardioblast proliferation (GO:0003266)2.70548777
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70327282
62nucleobase catabolic process (GO:0046113)2.70006067
63spermatid nucleus differentiation (GO:0007289)2.69316771
64cell-cell signaling involved in cell fate commitment (GO:0045168)2.67949473
65microtubule polymerization or depolymerization (GO:0031109)2.67889119
66mesenchyme morphogenesis (GO:0072132)2.67751961
67embryonic foregut morphogenesis (GO:0048617)2.67205782
68positive regulation of male gonad development (GO:2000020)2.66928613
69primitive streak formation (GO:0090009)2.65325659
70regulation of mRNA 3-end processing (GO:0031440)2.63198150
71glomerular filtration (GO:0003094)2.63141976
72interkinetic nuclear migration (GO:0022027)2.61913031
73central nervous system neuron axonogenesis (GO:0021955)2.60471702
74planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60309258
75regulation of heart morphogenesis (GO:2000826)2.60307120
76smoothened signaling pathway (GO:0007224)2.59920174
77regulation of timing of cell differentiation (GO:0048505)2.59718650
78cerebral cortex cell migration (GO:0021795)2.58720809
79neuroblast proliferation (GO:0007405)2.58192216
80head development (GO:0060322)2.57565859
81peptidyl-threonine dephosphorylation (GO:0035970)2.57393833
82metaphase plate congression (GO:0051310)2.56931688
83negative regulation of axon guidance (GO:1902668)2.56812895
84notochord development (GO:0030903)2.56704682
85dopaminergic neuron differentiation (GO:0071542)2.55554770
86positive regulation of Rho protein signal transduction (GO:0035025)2.54981946
87nucleosome disassembly (GO:0006337)2.53606017
88protein-DNA complex disassembly (GO:0032986)2.53606017
89somite rostral/caudal axis specification (GO:0032525)2.53002552
90regulation of mesenchymal cell apoptotic process (GO:2001053)2.51809998
91regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.51562279
92positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.51562279
93kidney mesenchyme development (GO:0072074)2.51325206
94endocardial cushion morphogenesis (GO:0003203)2.51284495
95cranial nerve morphogenesis (GO:0021602)2.50232908
96regulation of male gonad development (GO:2000018)2.49460603
97renal filtration (GO:0097205)2.47665705
98somite development (GO:0061053)2.47515123
99mitotic metaphase plate congression (GO:0007080)2.47228543
100neural precursor cell proliferation (GO:0061351)2.46986043
101negative regulation of RNA splicing (GO:0033119)2.46415131
102hindbrain development (GO:0030902)2.46390626
103cytokinetic process (GO:0032506)2.46343594
104left/right axis specification (GO:0070986)2.46079225
105cochlea morphogenesis (GO:0090103)2.45871638
106sister chromatid segregation (GO:0000819)2.45333596
107negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.44998106
108lymph vessel development (GO:0001945)2.44746387
109positive regulation of interleukin-8 secretion (GO:2000484)2.44384969
110establishment of tissue polarity (GO:0007164)2.44081353
111establishment of planar polarity (GO:0001736)2.44081353
112cilium organization (GO:0044782)2.43516714
113cilium assembly (GO:0042384)2.43077125
114embryonic hemopoiesis (GO:0035162)2.42740645
115dorsal/ventral neural tube patterning (GO:0021904)2.41966458
116exocrine pancreas development (GO:0031017)2.40764944
117face development (GO:0060324)2.40738112
118regulation of establishment of planar polarity (GO:0090175)2.40651822
119ventricular system development (GO:0021591)2.40641652
120developmental induction (GO:0031128)2.40504278
121generation of neurons (GO:0048699)2.39772049
122mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39492915
123spinal cord development (GO:0021510)2.39374384
124telencephalon cell migration (GO:0022029)2.38600605
125epithelial tube branching involved in lung morphogenesis (GO:0060441)2.38078234
126coronary vasculature morphogenesis (GO:0060977)2.36686869
127venous blood vessel morphogenesis (GO:0048845)2.36469630
128cilium morphogenesis (GO:0060271)2.35538456
129negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.35282236
130positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.34581627
131epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.34222748
132hippo signaling (GO:0035329)2.33722578
133regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.33500155
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.33383196
135positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.33304555
136positive regulation of gastrulation (GO:2000543)2.32744075
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.32460877
138regulation of translation, ncRNA-mediated (GO:0045974)2.32460877
139negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.32460877
140positive regulation of transcription regulatory region DNA binding (GO:2000679)2.31691573
141megakaryocyte development (GO:0035855)2.30935249
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.30664561
143outer ear morphogenesis (GO:0042473)2.28223995
144somatic stem cell division (GO:0048103)2.26946288
145atrial septum morphogenesis (GO:0060413)2.25777288
146pattern specification involved in kidney development (GO:0061004)2.25024691
147face morphogenesis (GO:0060325)2.24592600
148cell proliferation involved in metanephros development (GO:0072203)2.23443131
149vascular endothelial growth factor signaling pathway (GO:0038084)2.21177776
150cardiac myofibril assembly (GO:0055003)2.20716839
151lymphoid progenitor cell differentiation (GO:0002320)2.20294662
152photoreceptor cell maintenance (GO:0045494)2.18979712
153non-canonical Wnt signaling pathway (GO:0035567)2.18087630
154glomerulus development (GO:0032835)2.17447255
155blood vessel maturation (GO:0001955)2.16873649
156DNA topological change (GO:0006265)2.16763170
157positive regulation of protein deacetylation (GO:0090312)2.16712515
158regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.16000175
159cell migration involved in heart development (GO:0060973)2.15324950
160positive regulation of gene expression, epigenetic (GO:0045815)2.15288998
161radial glial cell differentiation (GO:0060019)2.14630778
162negative regulation of mRNA processing (GO:0050686)2.14405033
163glucocorticoid receptor signaling pathway (GO:0042921)2.13717567
164regulation of stem cell maintenance (GO:2000036)2.13712807
165embryonic eye morphogenesis (GO:0048048)2.12920947
166glomerular basement membrane development (GO:0032836)2.11450049
167positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.10295594
168positive regulation of mRNA catabolic process (GO:0061014)2.10292771
169positive regulation of hormone metabolic process (GO:0032352)2.09907173
170secretory granule organization (GO:0033363)2.09723975
171regulation of mesenchymal cell proliferation (GO:0010464)2.08244322
172urogenital system development (GO:0001655)2.07214570
173cell proliferation involved in kidney development (GO:0072111)2.06863123
174positive regulation by host of viral transcription (GO:0043923)2.06567701
175alternative mRNA splicing, via spliceosome (GO:0000380)2.05844884
176heart morphogenesis (GO:0003007)2.05725470
177gland morphogenesis (GO:0022612)2.05633813
178eye morphogenesis (GO:0048592)2.05490738
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.05184947
180mesodermal cell differentiation (GO:0048333)2.05147216
181epithelial cell fate commitment (GO:0072148)2.04287897
182negative regulation of erythrocyte differentiation (GO:0045647)2.04095316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.17082609
2TP63_19390658_ChIP-ChIP_HaCaT_Human3.59869006
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45397674
4EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.08134427
5SCL_19346495_ChIP-Seq_HPC-7_Human2.90644544
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.89906433
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.77138411
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.72654952
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70206325
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68737677
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.44334967
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43314489
13FUS_26573619_Chip-Seq_HEK293_Human2.42519529
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41408811
15IGF1R_20145208_ChIP-Seq_DFB_Human2.37667720
16TAF15_26573619_Chip-Seq_HEK293_Human2.37619495
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.28819226
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23109347
19MYC_22102868_ChIP-Seq_BL_Human2.13234681
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04049664
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.02854070
22DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.99103105
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.97971917
24CIITA_25753668_ChIP-Seq_RAJI_Human1.96130273
25GBX2_23144817_ChIP-Seq_PC3_Human1.94304830
26RUNX_20019798_ChIP-Seq_JUKART_Human1.93708179
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.92822974
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85468939
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.83506669
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82386550
31* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81365896
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76170082
33TCF7_22412390_ChIP-Seq_EML_Mouse1.75946100
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73303555
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69168808
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68858532
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68445844
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.67363965
39E2F7_22180533_ChIP-Seq_HELA_Human1.66440933
40P300_19829295_ChIP-Seq_ESCs_Human1.65568009
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65425722
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65425722
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64432795
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64415937
45EZH2_22144423_ChIP-Seq_EOC_Human1.63829898
46KDM2B_26808549_Chip-Seq_DND41_Human1.63795919
47* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.61324429
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.61270706
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58471363
50VDR_21846776_ChIP-Seq_THP-1_Human1.57009241
51* ISL1_27105846_Chip-Seq_CPCs_Mouse1.55527151
52* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55420570
53ZNF274_21170338_ChIP-Seq_K562_Hela1.55358812
54STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.54977225
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54450231
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.54025637
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53484333
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.52523313
59SMAD4_21799915_ChIP-Seq_A2780_Human1.52259863
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50074073
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49989234
62RNF2_27304074_Chip-Seq_NSC_Mouse1.49704366
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48982717
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.47538408
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45984947
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45885827
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.44278317
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43081980
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39788022
70VDR_24763502_ChIP-Seq_THP-1_Human1.39787485
71* RING1B_27294783_Chip-Seq_NPCs_Mouse1.39555131
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39250312
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37145052
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.36449873
75CLOCK_20551151_ChIP-Seq_293T_Human1.36297275
76AR_25329375_ChIP-Seq_VCAP_Human1.34899010
77* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32825026
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32769394
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31214634
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30629953
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29428402
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29149730
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28313690
84VDR_22108803_ChIP-Seq_LS180_Human1.27806790
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26980600
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.26367950
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26159767
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.25040889
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.24504570
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.24504570
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24283138
92AHR_22903824_ChIP-Seq_MCF-7_Human1.22719658
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22276629
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.22073570
95* ER_23166858_ChIP-Seq_MCF-7_Human1.21922553
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.20257560
97* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19970394
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.19612591
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17907422
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17868806
101BRD4_25478319_ChIP-Seq_HGPS_Human1.17791250
102TP53_16413492_ChIP-PET_HCT116_Human1.17192594
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16687362
104STAT3_23295773_ChIP-Seq_U87_Human1.16552253
105* UTX_26944678_Chip-Seq_JUKART_Human1.16486212
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16340533
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.15487968
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15296426
109SOX9_26525672_Chip-Seq_HEART_Mouse1.15296304
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15182936
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.15033322
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14423328
113EWS_26573619_Chip-Seq_HEK293_Human1.14287211
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.13961227
115* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13533012
116MAF_26560356_Chip-Seq_TH1_Human1.13299900
117UBF1/2_26484160_Chip-Seq_HMECs_Human1.13258849
118ELK1_19687146_ChIP-ChIP_HELA_Human1.12996120
119EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12886618
120RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12886618
121RNF2_27304074_Chip-Seq_ESCs_Mouse1.12543658
122* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12105064
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11686986
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10592314
125* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10250466
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09970247
127TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09724612
128TP53_18474530_ChIP-ChIP_U2OS_Human1.08433035
129BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08344365
130RUNX2_22187159_ChIP-Seq_PCA_Human1.07727286
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.07238577
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05401510
133NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04499466
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04499466
135CBP_20019798_ChIP-Seq_JUKART_Human1.03257882
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03257882
137* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02835688
138SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02627903
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02584210
140CJUN_26792858_Chip-Seq_BT549_Human1.02524164
141P53_22387025_ChIP-Seq_ESCs_Mouse1.02126072
142KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01701443
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01701443
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01701443
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01481850
146FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01278945
147GATA2_21666600_ChIP-Seq_HMVEC_Human1.00689840
148MYB_26560356_Chip-Seq_TH2_Human0.99264780
149SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98890770
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97545825
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.97154998
152CHD1_26751641_Chip-Seq_LNCaP_Human0.96512301
153TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94770526
154TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94577833
155SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94310981
156JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93877478
157SMAD_19615063_ChIP-ChIP_OVARY_Human0.92498040
158CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91294499
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91275545
160SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91115624
161SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90307439
162YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90084117
163* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90045791
164AR_21572438_ChIP-Seq_LNCaP_Human0.88803418
165* RING1B_27294783_Chip-Seq_ESCs_Mouse0.88690247
166NFI_21473784_ChIP-Seq_ESCs_Mouse0.88262011
167POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87972761
168E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87366995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.24077018
2MP0010030_abnormal_orbit_morphology2.81206193
3MP0003890_abnormal_embryonic-extraembry2.73859502
4MP0006072_abnormal_retinal_apoptosis2.58684555
5MP0000566_synostosis2.29482217
6MP0000049_abnormal_middle_ear2.24902556
7MP0000569_abnormal_digit_pigmentation2.18161754
8MP0002938_white_spotting2.14748997
9MP0000537_abnormal_urethra_morphology2.13299107
10MP0003787_abnormal_imprinting2.10601006
11MP0002234_abnormal_pharynx_morphology2.05374797
12MP0002009_preneoplasia1.95753696
13MP0000733_abnormal_muscle_development1.94167369
14MP0006054_spinal_hemorrhage1.90647126
15MP0004133_heterotaxia1.80984191
16MP0004808_abnormal_hematopoietic_stem1.80547779
17MP0003385_abnormal_body_wall1.80461177
18MP0000428_abnormal_craniofacial_morphol1.79603519
19* MP0001879_abnormal_lymphatic_vessel1.73309607
20MP0009250_abnormal_appendicular_skeleto1.73190679
21MP0002751_abnormal_autonomic_nervous1.66054249
22MP0003942_abnormal_urinary_system1.62972637
23MP0008789_abnormal_olfactory_epithelium1.61157757
24MP0005394_taste/olfaction_phenotype1.60395671
25MP0005499_abnormal_olfactory_system1.60395671
26MP0001529_abnormal_vocalization1.60181383
27MP0001293_anophthalmia1.58280606
28MP0001270_distended_abdomen1.57375720
29MP0002928_abnormal_bile_duct1.57230577
30MP0002396_abnormal_hematopoietic_system1.56151270
31MP0005253_abnormal_eye_physiology1.55268948
32* MP0003935_abnormal_craniofacial_develop1.51579529
33MP0000465_gastrointestinal_hemorrhage1.46958989
34MP0009384_cardiac_valve_regurgitation1.46865613
35MP0002249_abnormal_larynx_morphology1.45698883
36MP0005551_abnormal_eye_electrophysiolog1.44468818
37MP0006292_abnormal_olfactory_placode1.43959135
38MP0003937_abnormal_limbs/digits/tail_de1.43943481
39MP0002877_abnormal_melanocyte_morpholog1.43075318
40MP0003119_abnormal_digestive_system1.42784492
41MP0003941_abnormal_skin_development1.42231632
42MP0003011_delayed_dark_adaptation1.40948915
43MP0010368_abnormal_lymphatic_system1.39942219
44MP0006276_abnormal_autonomic_nervous1.38494818
45MP0002282_abnormal_trachea_morphology1.37727560
46MP0000647_abnormal_sebaceous_gland1.35354856
47MP0001984_abnormal_olfaction1.35214963
48MP0005391_vision/eye_phenotype1.34840574
49MP0000955_abnormal_spinal_cord1.32365929
50MP0005076_abnormal_cell_differentiation1.32169120
51MP0002932_abnormal_joint_morphology1.31938630
52MP0003122_maternal_imprinting1.31274618
53MP0003755_abnormal_palate_morphology1.31118842
54MP0000534_abnormal_ureter_morphology1.30949515
55MP0002116_abnormal_craniofacial_bone1.30902077
56MP0001286_abnormal_eye_development1.29344012
57MP0002177_abnormal_outer_ear1.28104126
58MP0002102_abnormal_ear_morphology1.25405717
59MP0003300_gastrointestinal_ulcer1.25244499
60MP0010678_abnormal_skin_adnexa1.24385779
61MP0000427_abnormal_hair_cycle1.22717230
62MP0004145_abnormal_muscle_electrophysio1.21487642
63MP0009278_abnormal_bone_marrow1.20589177
64MP0000631_abnormal_neuroendocrine_gland1.19988349
65MP0003567_abnormal_fetal_cardiomyocyte1.19900249
66MP0008057_abnormal_DNA_replication1.19280351
67MP0009697_abnormal_copulation1.19226968
68MP0009053_abnormal_anal_canal1.18283174
69MP0004084_abnormal_cardiac_muscle1.17620177
70MP0003283_abnormal_digestive_organ1.16509918
71MP0003943_abnormal_hepatobiliary_system1.15255068
72MP0002822_catalepsy1.14273006
73MP0002697_abnormal_eye_size1.13414561
74MP0003115_abnormal_respiratory_system1.13203042
75MP0002233_abnormal_nose_morphology1.11959795
76MP0002653_abnormal_ependyma_morphology1.11904919
77MP0005195_abnormal_posterior_eye1.10852856
78MP0005084_abnormal_gallbladder_morpholo1.10806944
79MP0008961_abnormal_basal_metabolism1.09450229
80MP0010630_abnormal_cardiac_muscle1.09170540
81MP0000026_abnormal_inner_ear1.08721575
82MP0002092_abnormal_eye_morphology1.08720896
83MP0000762_abnormal_tongue_morphology1.08481636
84MP0000432_abnormal_head_morphology1.08367610
85MP0003221_abnormal_cardiomyocyte_apopto1.07370562
86MP0003880_abnormal_central_pattern1.05885491
87MP0002152_abnormal_brain_morphology1.05837687
88MP0002166_altered_tumor_susceptibility1.05217216
89MP0003938_abnormal_ear_development1.03571391
90MP0002184_abnormal_innervation1.03175475
91MP0003121_genomic_imprinting1.02769604
92MP0001958_emphysema1.01971871
93* MP0002925_abnormal_cardiovascular_devel1.01411549
94MP0004233_abnormal_muscle_weight1.00618961
95MP0000767_abnormal_smooth_muscle0.99952869
96MP0008877_abnormal_DNA_methylation0.99147290
97* MP0002081_perinatal_lethality0.98943658
98MP0005248_abnormal_Harderian_gland0.98894561
99MP0000383_abnormal_hair_follicle0.98811043
100MP0005171_absent_coat_pigmentation0.98074326
101MP0000678_abnormal_parathyroid_gland0.97583714
102MP0005187_abnormal_penis_morphology0.96670130
103MP0009703_decreased_birth_body0.96451144
104MP0005623_abnormal_meninges_morphology0.95938858
105MP0002638_abnormal_pupillary_reflex0.93077188
106MP0003828_pulmonary_edema0.92556868
107MP0001324_abnormal_eye_pigmentation0.92109195
108MP0001299_abnormal_eye_distance/0.92051860
109MP0004215_abnormal_myocardial_fiber0.91921797
110MP0002752_abnormal_somatic_nervous0.91801080
111MP0004134_abnormal_chest_morphology0.91337375
112MP0004197_abnormal_fetal_growth/weight/0.90918058
113MP0003279_aneurysm0.90672535
114MP0005508_abnormal_skeleton_morphology0.90531648
115MP0002111_abnormal_tail_morphology0.88894409
116MP0002084_abnormal_developmental_patter0.88829466
117MP0004272_abnormal_basement_membrane0.87359680
118MP0004036_abnormal_muscle_relaxation0.86609098
119MP0002882_abnormal_neuron_morphology0.85416771
120* MP0002085_abnormal_embryonic_tissue0.84668511
121MP0000163_abnormal_cartilage_morphology0.83665889
122MP0002109_abnormal_limb_morphology0.83392041
123MP0000516_abnormal_urinary_system0.82995589
124MP0005367_renal/urinary_system_phenotyp0.82995589
125MP0002114_abnormal_axial_skeleton0.82874538
126MP0000003_abnormal_adipose_tissue0.82354523
127MP0000759_abnormal_skeletal_muscle0.81420543
128MP0001727_abnormal_embryo_implantation0.80869428
129MP0000266_abnormal_heart_morphology0.79109470
130MP0000778_abnormal_nervous_system0.78757525
131MP0002095_abnormal_skin_pigmentation0.78370843
132MP0004087_abnormal_muscle_fiber0.78277822
133MP0004885_abnormal_endolymph0.77581779
134MP0003861_abnormal_nervous_system0.77443085
135MP0003315_abnormal_perineum_morphology0.76587657
136MP0005503_abnormal_tendon_morphology0.76408692
137MP0000703_abnormal_thymus_morphology0.76346235
138MP0004142_abnormal_muscle_tone0.76016455
139MP0001340_abnormal_eyelid_morphology0.75836926
140MP0008007_abnormal_cellular_replicative0.75789778
141MP0003123_paternal_imprinting0.75494722
142MP0000751_myopathy0.75491780
143MP0002106_abnormal_muscle_physiology0.75304854
144MP0003950_abnormal_plasma_membrane0.75071344
145MP0002160_abnormal_reproductive_system0.74535096
146MP0004811_abnormal_neuron_physiology0.71469111
147MP0002557_abnormal_social/conspecific_i0.70972774
148MP0001346_abnormal_lacrimal_gland0.70738259

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)3.42060769
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.35820369
3True hermaphroditism (HP:0010459)3.29726800
4Abnormal rod and cone electroretinograms (HP:0008323)3.10740092
5Pendular nystagmus (HP:0012043)3.10165961
6Short 4th metacarpal (HP:0010044)3.00106312
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.00106312
8Chorioretinal atrophy (HP:0000533)2.94464095
9Abnormality of the fingertips (HP:0001211)2.92640756
10Volvulus (HP:0002580)2.81486454
11Cortical dysplasia (HP:0002539)2.81073597
12Central scotoma (HP:0000603)2.79623965
13Oligodactyly (hands) (HP:0001180)2.77436958
14Abnormality of the labia minora (HP:0012880)2.75527623
15Congenital stationary night blindness (HP:0007642)2.75416698
16Septo-optic dysplasia (HP:0100842)2.67156565
17Abnormal respiratory motile cilium morphology (HP:0005938)2.60009100
18Abnormal respiratory epithelium morphology (HP:0012253)2.60009100
19Pancreatic fibrosis (HP:0100732)2.58345224
20Missing ribs (HP:0000921)2.58226862
21Midline defect of the nose (HP:0004122)2.56914995
22Scotoma (HP:0000575)2.49230539
23Abnormality of the 4th metacarpal (HP:0010012)2.45259980
24Long eyelashes (HP:0000527)2.44567904
25Abnormal ciliary motility (HP:0012262)2.43206573
26Papillary thyroid carcinoma (HP:0002895)2.41916746
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.40534338
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.39231892
29Absent/shortened dynein arms (HP:0200106)2.39231892
30Abnormal respiratory motile cilium physiology (HP:0012261)2.37196882
31Rhinitis (HP:0012384)2.35121171
32Pancreatic cysts (HP:0001737)2.34761433
33Hepatoblastoma (HP:0002884)2.32049430
34Molar tooth sign on MRI (HP:0002419)2.31946817
35Abnormality of midbrain morphology (HP:0002418)2.31946817
36Abnormality of the left ventricular outflow tract (HP:0011103)2.31912082
37Subaortic stenosis (HP:0001682)2.31912082
38Keratoconus (HP:0000563)2.29034670
39Increased corneal curvature (HP:0100692)2.29034670
40Nephronophthisis (HP:0000090)2.28332596
41Gait imbalance (HP:0002141)2.26632114
42Severe visual impairment (HP:0001141)2.26325358
43Vaginal atresia (HP:0000148)2.25186312
44Congenital primary aphakia (HP:0007707)2.24374447
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.23554926
46Intestinal atresia (HP:0011100)2.23455773
47Rectal prolapse (HP:0002035)2.21969401
48Genital tract atresia (HP:0001827)2.21275681
49Medial flaring of the eyebrow (HP:0010747)2.20506754
50Macroorchidism (HP:0000053)2.20344720
51Specific learning disability (HP:0001328)2.19403798
52Oligodactyly (HP:0012165)2.18684631
53Renal duplication (HP:0000075)2.17929637
54Abolished electroretinogram (ERG) (HP:0000550)2.16868460
55Trigonocephaly (HP:0000243)2.13426474
56Shallow orbits (HP:0000586)2.13267732
57Nephrogenic diabetes insipidus (HP:0009806)2.12314421
58Abnormality of the renal medulla (HP:0100957)2.11552909
59Absent septum pellucidum (HP:0001331)2.11392464
60Colon cancer (HP:0003003)2.09746604
61Abnormality of the ischium (HP:0003174)2.06576670
62Posterior subcapsular cataract (HP:0007787)2.05985864
63Sensory axonal neuropathy (HP:0003390)2.05939079
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.05200991
65Progressive inability to walk (HP:0002505)2.04629199
66Retinal dysplasia (HP:0007973)2.04019922
67Sclerocornea (HP:0000647)2.03158995
68Hip dysplasia (HP:0001385)2.01928585
69Attenuation of retinal blood vessels (HP:0007843)2.01780194
70Abnormality of the right ventricle (HP:0001707)2.00230559
71Narrow palate (HP:0000189)1.99583706
72Hypoplastic ischia (HP:0003175)1.99484167
73Postaxial foot polydactyly (HP:0001830)1.98839332
74Hypoplastic iliac wings (HP:0002866)1.97055393
75Abnormality of the diencephalon (HP:0010662)1.96551116
76Chronic hepatic failure (HP:0100626)1.96090462
77Obsessive-compulsive behavior (HP:0000722)1.96029919
78Poor coordination (HP:0002370)1.95825958
79Abnormality of the septum pellucidum (HP:0007375)1.95809733
80Cystic hygroma (HP:0000476)1.94234658
8111 pairs of ribs (HP:0000878)1.94118639
82Abnormality of macular pigmentation (HP:0008002)1.93620373
83Morphological abnormality of the middle ear (HP:0008609)1.93243356
84Optic nerve hypoplasia (HP:0000609)1.93118120
85Broad metatarsal (HP:0001783)1.91747295
86Abnormal hair whorl (HP:0010721)1.91234148
87Increased nuchal translucency (HP:0010880)1.90480481
88High anterior hairline (HP:0009890)1.86375076
89Thick eyebrow (HP:0000574)1.85509271
90Thyroid carcinoma (HP:0002890)1.85432897
91Increased number of teeth (HP:0011069)1.85403732
92Postaxial hand polydactyly (HP:0001162)1.85328243
93Abnormality of the parietal bone (HP:0002696)1.85305015
94Abnormality of the hip-girdle musculature (HP:0001445)1.85181326
95Abnormality of the musculature of the pelvis (HP:0001469)1.85181326
96Aortic aneurysm (HP:0004942)1.84410788
97Hypoplastic labia majora (HP:0000059)1.84283860
98Rimmed vacuoles (HP:0003805)1.84280873
99Optic nerve coloboma (HP:0000588)1.83701749
100Curly hair (HP:0002212)1.83515980
101Type II diabetes mellitus (HP:0005978)1.82015694
102Supernumerary spleens (HP:0009799)1.81821292
103Drooling (HP:0002307)1.81398368
104Esophageal atresia (HP:0002032)1.80223771
105Increased density of long bones (HP:0006392)1.79313261
106Pigmentary retinal degeneration (HP:0001146)1.78894232
107Micropenis (HP:0000054)1.77925110
108Bicuspid aortic valve (HP:0001647)1.77786696
109Spinal cord lesions (HP:0100561)1.77083454
110Syringomyelia (HP:0003396)1.77083454
111Anencephaly (HP:0002323)1.74731922
112Type II lissencephaly (HP:0007260)1.74658666
113Short middle phalanx of the 5th finger (HP:0004220)1.74403935
114Cystic liver disease (HP:0006706)1.74266604
115Broad-based gait (HP:0002136)1.74065738
116Persistence of primary teeth (HP:0006335)1.72762740
117Occipital encephalocele (HP:0002085)1.72430617
118Male pseudohermaphroditism (HP:0000037)1.72022979
119Abnormality of the pubic bones (HP:0003172)1.71697874
120Germ cell neoplasia (HP:0100728)1.71160519
121Preaxial hand polydactyly (HP:0001177)1.71124014
122Labial hypoplasia (HP:0000066)1.70295716
123Synophrys (HP:0000664)1.70146827
124Gastrointestinal atresia (HP:0002589)1.69178395
125Abnormality of the metopic suture (HP:0005556)1.68353936
126Flat cornea (HP:0007720)1.67788822
127Neoplasm of the adrenal cortex (HP:0100641)1.67271785
128Pulmonic stenosis (HP:0001642)1.67167119
129Maternal diabetes (HP:0009800)1.66465326
130Large earlobe (HP:0009748)1.66430088
131Hyperacusis (HP:0010780)1.66260556
132Truncal obesity (HP:0001956)1.66021606
133Abnormality of the labia majora (HP:0012881)1.65476498
134Fibular hypoplasia (HP:0003038)1.64613469
135Sex reversal (HP:0012245)1.64500566
136Abnormal sex determination (HP:0012244)1.64500566
137Abnormal number of incisors (HP:0011064)1.64390625
138Scrotal hypoplasia (HP:0000046)1.64153347
139Calf muscle hypertrophy (HP:0008981)1.64054825
140Median cleft lip (HP:0000161)1.63759009
141Constricted visual fields (HP:0001133)1.63546777
142Dyschromatopsia (HP:0007641)1.62774486
143Hypoplastic female external genitalia (HP:0012815)1.62514916
144Lissencephaly (HP:0001339)1.62117993
145Bifid tongue (HP:0010297)1.62056668
146Anal stenosis (HP:0002025)1.61893297
147Excessive salivation (HP:0003781)1.61783743
148Deep philtrum (HP:0002002)1.61715687
149Abnormality of the nasal septum (HP:0000419)1.61258704
150Adrenal hypoplasia (HP:0000835)1.61091458
151Broad toe (HP:0001837)1.61015141
152Dental malocclusion (HP:0000689)1.61000437
153Anophthalmia (HP:0000528)1.60040534
154Broad thumb (HP:0011304)1.58593388
155Neoplasm of the small intestine (HP:0100833)1.57232522
156Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56860862
157Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.56757679
158Weak cry (HP:0001612)1.56476247
159Lip pit (HP:0100267)1.55826953
160Chin dimple (HP:0010751)1.55021904
161Arterial tortuosity (HP:0005116)1.55021395
162Hypoplasia of the iris (HP:0007676)1.54060492
163Abnormality of the intervertebral disk (HP:0005108)1.50074618
164Exercise-induced myalgia (HP:0003738)1.49615186
165Cutis marmorata (HP:0000965)1.49027782
166Aortic dissection (HP:0002647)1.48719413
167Broad ribs (HP:0000885)1.47656500
168Smooth philtrum (HP:0000319)1.46918753
169Down-sloping shoulders (HP:0200021)1.46742129
170Buphthalmos (HP:0000557)1.46011030
171Muscle fiber inclusion bodies (HP:0100299)1.45129460
172Short 5th finger (HP:0009237)1.44879453
173Asymmetry of the thorax (HP:0001555)1.44571727
174Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.43473811
175Proximal placement of thumb (HP:0009623)1.43333480
176Acute myeloid leukemia (HP:0004808)1.42748940
177Neoplasm of the rectum (HP:0100743)1.42688449
178Tapered finger (HP:0001182)1.42454451
179Broad hallux (HP:0010055)1.42162968
180Scapular winging (HP:0003691)1.42107458
181Exostoses (HP:0100777)1.41456995
182Hematochezia (HP:0002573)1.40338389
183Spondylolisthesis (HP:0003302)1.39778182
184Congenital sensorineural hearing impairment (HP:0008527)1.39254601
185Gastrointestinal stroma tumor (HP:0100723)1.38997260
186Low anterior hairline (HP:0000294)1.37206372
187Mitral regurgitation (HP:0001653)1.36759715
188Subacute progressive viral hepatitis (HP:0006572)1.35866122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.28284502
2CASK2.90804749
3DMPK2.87260143
4WEE12.69127092
5EPHB22.58733111
6MST42.37433278
7EEF2K2.37362989
8MAP3K102.34342065
9MAP3K42.25100436
10BRD42.21327583
11TTN2.16202378
12HIPK22.07358829
13DYRK32.00448369
14TRIB31.98518196
15TGFBR11.97523743
16MKNK11.90283438
17PDGFRA1.89949057
18CAMK1G1.88532225
19BRSK21.83888834
20TGFBR21.80592354
21WNK31.75197723
22MAP2K71.67302553
23MARK11.66781645
24RPS6KA41.66417064
25BCR1.63708382
26PTK61.51160994
27CDK91.50537451
28CAMK1D1.46345871
29NLK1.44103697
30PASK1.41881286
31EPHA31.41457775
32BTK1.41417355
33TRIM281.40973087
34TSSK61.40158423
35SIK11.30267720
36DYRK1B1.28720229
37MKNK21.27955652
38SIK31.27211271
39TIE11.24673119
40MAPK151.24612355
41LATS11.23450715
42LRRK21.20515050
43TNIK1.19403195
44MUSK1.18720519
45PDGFRB1.18575234
46IRAK21.18505168
47MAP2K41.18102290
48CDK191.16988548
49INSRR1.16978697
50KIT1.16978212
51ITK1.16790875
52NUAK11.16445399
53ERBB21.12078468
54DYRK21.11248923
55STK38L1.06007058
56ILK1.05945153
57SRPK11.05501552
58FGFR21.05197971
59EPHB11.04279934
60IRAK11.03587535
61FGFR31.02443453
62TAOK11.00658841
63PIK3CA0.98862124
64ERBB30.96962470
65MET0.96077212
66AKT30.95405748
67PLK40.95017279
68MAP4K10.94560029
69PLK30.93679538
70PLK10.93503003
71CSNK1A1L0.93499083
72PRKD20.93256822
73CDK60.91268625
74CDK30.89618723
75CDK120.89491524
76MTOR0.88829455
77SGK20.87684665
78TTK0.85441113
79MAP3K60.84747129
80JAK30.82850815
81KSR10.80774670
82PAK20.78359978
83STK100.78289841
84STK40.77601496
85CHUK0.77443111
86EPHA20.76997356
87PRKD10.75794275
88RPS6KA50.75028464
89OBSCN0.73449762
90PAK30.73333834
91TEC0.73285811
92MAP3K20.72181781
93DYRK1A0.71237413
94GRK10.69565250
95BMPR1B0.69470402
96RIPK10.69092871
97NEK90.68192554
98MAP2K20.67776305
99ROCK10.67401355
100NTRK20.66993843
101MAP3K70.66733979
102GSK3A0.66633996
103RPS6KB20.65813168
104YES10.64848315
105MARK20.62429997
106MAPK90.62106975
107WNK10.58888741
108MAPK130.58847443
109NEK20.58244154
110SGK4940.57026847
111SGK2230.57026847
112CSF1R0.56418831
113CSNK1G10.56222397
114FGFR10.55580562
115PRKAA20.54194423
116PKN20.53799521
117CHEK20.52610005
118STK110.52179039
119RPS6KA20.52019966
120CDC70.51897602
121UHMK10.51067668
122PKN10.50136243
123AKT10.50106588
124PHKG20.50001395
125PHKG10.50001395
126PRKCH0.49925607
127MAPKAPK50.48640993
128ATR0.45808960
129CSNK1G30.45292986
130AURKB0.45291090
131SIK20.44770752
132TYRO30.44732794
133STK30.44549910
134CCNB10.44210708
135ROCK20.44063622
136CAMK40.43975222
137BRSK10.43613227
138CDK80.43086719
139RPS6KA60.43064566
140MAPKAPK20.42957907
141ERBB40.42637214
142SGK30.42280870
143PAK40.42160846
144EPHA40.41759942
145STK390.40960319
146AKT20.40738411
147CDK40.40370091
148PRKACB0.40282112
149EIF2AK20.39404034
150VRK10.39249495
151TRPM70.39199664
152ZAK0.38939692
153MELK0.38097579
154MST1R0.35139037
155CHEK10.30104681
156ATM0.29928267

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.82086919
2Basal transcription factors_Homo sapiens_hsa030222.21967450
3Notch signaling pathway_Homo sapiens_hsa043301.83612445
4Basal cell carcinoma_Homo sapiens_hsa052171.80962716
5Fanconi anemia pathway_Homo sapiens_hsa034601.68355112
6Chronic myeloid leukemia_Homo sapiens_hsa052201.67744825
7MicroRNAs in cancer_Homo sapiens_hsa052061.62744967
8Transcriptional misregulation in cancer_Homo sapiens_hsa052021.62595651
9Regulation of autophagy_Homo sapiens_hsa041401.57880149
10Non-homologous end-joining_Homo sapiens_hsa034501.54915451
11Olfactory transduction_Homo sapiens_hsa047401.50582602
12Cocaine addiction_Homo sapiens_hsa050301.49363312
13Steroid biosynthesis_Homo sapiens_hsa001001.45730227
14Focal adhesion_Homo sapiens_hsa045101.43582344
15Small cell lung cancer_Homo sapiens_hsa052221.42705736
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41851875
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41144608
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39208668
19Adherens junction_Homo sapiens_hsa045201.37704824
20Hippo signaling pathway_Homo sapiens_hsa043901.37301581
21Viral myocarditis_Homo sapiens_hsa054161.36876708
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33062264
23ECM-receptor interaction_Homo sapiens_hsa045121.32752550
24Dilated cardiomyopathy_Homo sapiens_hsa054141.32580776
25Hedgehog signaling pathway_Homo sapiens_hsa043401.32575440
26Colorectal cancer_Homo sapiens_hsa052101.32566943
27Pancreatic cancer_Homo sapiens_hsa052121.30801668
28Proteoglycans in cancer_Homo sapiens_hsa052051.29395496
29Wnt signaling pathway_Homo sapiens_hsa043101.28437207
30Renal cell carcinoma_Homo sapiens_hsa052111.26013124
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25614426
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23618929
33Prostate cancer_Homo sapiens_hsa052151.23296157
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20943249
35Pathways in cancer_Homo sapiens_hsa052001.19931293
36Platelet activation_Homo sapiens_hsa046111.18655824
37B cell receptor signaling pathway_Homo sapiens_hsa046621.16677265
38HTLV-I infection_Homo sapiens_hsa051661.13492979
39Spliceosome_Homo sapiens_hsa030401.11754802
40Gap junction_Homo sapiens_hsa045401.11614930
41Non-small cell lung cancer_Homo sapiens_hsa052231.10041450
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.09961086
43Cell cycle_Homo sapiens_hsa041101.08691331
44TGF-beta signaling pathway_Homo sapiens_hsa043501.07611813
45Endometrial cancer_Homo sapiens_hsa052131.07505154
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06220283
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04999555
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03974699
49ErbB signaling pathway_Homo sapiens_hsa040121.02783459
50Acute myeloid leukemia_Homo sapiens_hsa052211.02502429
51FoxO signaling pathway_Homo sapiens_hsa040681.01760973
52Axon guidance_Homo sapiens_hsa043601.01360153
53Hepatitis B_Homo sapiens_hsa051611.00483447
54mRNA surveillance pathway_Homo sapiens_hsa030151.00353181
55Lysine degradation_Homo sapiens_hsa003100.99221597
56Long-term depression_Homo sapiens_hsa047300.98228299
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98039824
58T cell receptor signaling pathway_Homo sapiens_hsa046600.97723246
59Dopaminergic synapse_Homo sapiens_hsa047280.97137068
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95543872
61Prolactin signaling pathway_Homo sapiens_hsa049170.94950219
62Glioma_Homo sapiens_hsa052140.92783437
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91262238
64Toxoplasmosis_Homo sapiens_hsa051450.89961098
65Thyroid cancer_Homo sapiens_hsa052160.89871708
66Melanogenesis_Homo sapiens_hsa049160.87680254
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.87292557
68Protein export_Homo sapiens_hsa030600.86392230
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85677896
70RNA degradation_Homo sapiens_hsa030180.85529041
71Herpes simplex infection_Homo sapiens_hsa051680.83809496
72Circadian rhythm_Homo sapiens_hsa047100.82167962
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.81746439
74Melanoma_Homo sapiens_hsa052180.81607000
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81152696
76Hematopoietic cell lineage_Homo sapiens_hsa046400.80891484
77Osteoclast differentiation_Homo sapiens_hsa043800.80791871
78Primary immunodeficiency_Homo sapiens_hsa053400.79367069
79Insulin resistance_Homo sapiens_hsa049310.78979882
80Rap1 signaling pathway_Homo sapiens_hsa040150.78831604
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.78781566
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78190309
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74997753
84Leishmaniasis_Homo sapiens_hsa051400.74959799
85mTOR signaling pathway_Homo sapiens_hsa041500.74764650
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74739905
87N-Glycan biosynthesis_Homo sapiens_hsa005100.74552998
88Measles_Homo sapiens_hsa051620.74337376
89Viral carcinogenesis_Homo sapiens_hsa052030.73224267
90Nicotine addiction_Homo sapiens_hsa050330.73194634
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72919800
92Ribosome_Homo sapiens_hsa030100.72424430
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72249262
94cAMP signaling pathway_Homo sapiens_hsa040240.71751448
95Bladder cancer_Homo sapiens_hsa052190.71358508
96MAPK signaling pathway_Homo sapiens_hsa040100.70826480
97Dorso-ventral axis formation_Homo sapiens_hsa043200.70557752
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69682377
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69649241
100Tight junction_Homo sapiens_hsa045300.68904756
101RNA transport_Homo sapiens_hsa030130.68358104
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68288316
103Choline metabolism in cancer_Homo sapiens_hsa052310.68115296
104AMPK signaling pathway_Homo sapiens_hsa041520.67611299
105Cholinergic synapse_Homo sapiens_hsa047250.67108696
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65094238
107TNF signaling pathway_Homo sapiens_hsa046680.65039694
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64263259
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63874575
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63413060
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63223642
112Shigellosis_Homo sapiens_hsa051310.61659753
113VEGF signaling pathway_Homo sapiens_hsa043700.60991401
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60651618
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.60376349
116p53 signaling pathway_Homo sapiens_hsa041150.59713318
117Ras signaling pathway_Homo sapiens_hsa040140.59078595
118Alcoholism_Homo sapiens_hsa050340.58366632
119Estrogen signaling pathway_Homo sapiens_hsa049150.58272401
120Antigen processing and presentation_Homo sapiens_hsa046120.58129999
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57434790
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57103888
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56567793
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56352678
125Cardiac muscle contraction_Homo sapiens_hsa042600.55635214
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53520438
127Serotonergic synapse_Homo sapiens_hsa047260.53406212
128Amphetamine addiction_Homo sapiens_hsa050310.53226934
129Circadian entrainment_Homo sapiens_hsa047130.53203562
130Renin secretion_Homo sapiens_hsa049240.52009833
131Oxytocin signaling pathway_Homo sapiens_hsa049210.51980625
132Homologous recombination_Homo sapiens_hsa034400.51066074
133Oocyte meiosis_Homo sapiens_hsa041140.51034465
134Huntingtons disease_Homo sapiens_hsa050160.50913683
135Morphine addiction_Homo sapiens_hsa050320.50392565
136Glutamatergic synapse_Homo sapiens_hsa047240.49593073
137Insulin signaling pathway_Homo sapiens_hsa049100.48991130
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47620896
139Glucagon signaling pathway_Homo sapiens_hsa049220.44372860
140Type II diabetes mellitus_Homo sapiens_hsa049300.43407272
141Nitrogen metabolism_Homo sapiens_hsa009100.43120001
142Inositol phosphate metabolism_Homo sapiens_hsa005620.42230002
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41599505

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