VEZF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone receptor signaling pathway (GO:0060396)9.63355215
2cellular response to growth hormone stimulus (GO:0071378)8.66312471
3sequestering of actin monomers (GO:0042989)8.21542905
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.59602057
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.57330766
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99490792
7positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)5.86677103
8ATP synthesis coupled proton transport (GO:0015986)5.85177887
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85177887
10regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)5.70758298
11neurotransmitter catabolic process (GO:0042135)5.03016577
12positive regulation of heat generation (GO:0031652)4.80298323
13response to growth hormone (GO:0060416)4.79225110
14positive regulation of receptor internalization (GO:0002092)4.42313626
15regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.07548169
16regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.04520819
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.99919621
18proteasome assembly (GO:0043248)3.95919009
19T-helper 1 type immune response (GO:0042088)3.91879291
20positive regulation of T cell cytokine production (GO:0002726)3.88440965
21regulation of non-canonical Wnt signaling pathway (GO:2000050)3.84585181
22activated T cell proliferation (GO:0050798)3.73944577
23primitive streak formation (GO:0090009)3.70611659
24thalamus development (GO:0021794)3.69760124
25gonadal mesoderm development (GO:0007506)3.66389302
26regulation of fever generation (GO:0031620)3.66113124
27positive regulation of bone resorption (GO:0045780)3.61870295
28positive regulation of bone remodeling (GO:0046852)3.61870295
29regulation of heat generation (GO:0031650)3.60789808
30positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.58133476
31dopaminergic neuron differentiation (GO:0071542)3.54122604
32actin nucleation (GO:0045010)3.53057199
33replication fork processing (GO:0031297)3.43438582
34JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.40432616
35positive regulation of prostaglandin secretion (GO:0032308)3.39813827
36oxidative phosphorylation (GO:0006119)3.39157459
37purine nucleotide salvage (GO:0032261)3.38869814
38toxin transport (GO:1901998)3.36539248
39GPI anchor biosynthetic process (GO:0006506)3.36209172
40regulation of dopamine metabolic process (GO:0042053)3.33343034
41regulation of catecholamine metabolic process (GO:0042069)3.33343034
42regulation of receptor internalization (GO:0002090)3.30977044
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29531100
44protein polyglutamylation (GO:0018095)3.25634584
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24676372
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24676372
47germ cell migration (GO:0008354)3.21244402
48GPI anchor metabolic process (GO:0006505)3.20762912
49mannosylation (GO:0097502)3.19917987
50regulation of prostaglandin secretion (GO:0032306)3.15840680
51regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)3.09948650
52regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.09284220
53positive regulation of uterine smooth muscle contraction (GO:0070474)3.08177477
54regulation of immunoglobulin secretion (GO:0051023)3.07221074
55regulation of interleukin-6 biosynthetic process (GO:0045408)3.04007782
56negative regulation of telomere maintenance (GO:0032205)2.91334618
57purine nucleobase biosynthetic process (GO:0009113)2.90158856
58electron transport chain (GO:0022900)2.89938969
59respiratory electron transport chain (GO:0022904)2.89609187
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89406260
61hydrogen ion transmembrane transport (GO:1902600)2.89182941
62estrogen biosynthetic process (GO:0006703)2.88530735
63tachykinin receptor signaling pathway (GO:0007217)2.76381786
64mitochondrial respiratory chain complex assembly (GO:0033108)2.75935654
65regulation of uterine smooth muscle contraction (GO:0070472)2.74217840
66positive regulation of protein homodimerization activity (GO:0090073)2.74030942
67protein complex biogenesis (GO:0070271)2.64789527
68endoderm formation (GO:0001706)2.64391041
69epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.64194655
70anatomical structure maturation (GO:0071695)2.62958147
71ATP biosynthetic process (GO:0006754)2.62764582
72righting reflex (GO:0060013)2.61733339
73signal peptide processing (GO:0006465)2.58871417
74otic vesicle formation (GO:0030916)2.58491782
75signal transduction involved in regulation of gene expression (GO:0023019)2.56518098
76translational termination (GO:0006415)2.55487980
77positive regulation of icosanoid secretion (GO:0032305)2.52772520
78chemosensory behavior (GO:0007635)2.51536339
79positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.47952922
80proton transport (GO:0015992)2.46235210
81viral transcription (GO:0019083)2.46000332
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.45780096
83cellular ketone body metabolic process (GO:0046950)2.44998829
84hydrogen transport (GO:0006818)2.44822042
85cotranslational protein targeting to membrane (GO:0006613)2.44558231
86regulation of icosanoid secretion (GO:0032303)2.43485985
87protein targeting to ER (GO:0045047)2.40457671
88microglial cell activation (GO:0001774)2.40264256
89regulation of mesenchymal cell apoptotic process (GO:2001053)2.39981389
90nucleobase biosynthetic process (GO:0046112)2.39507551
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.39363621
92NADH dehydrogenase complex assembly (GO:0010257)2.39363621
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39363621
94platelet dense granule organization (GO:0060155)2.38059727
95dendrite morphogenesis (GO:0048813)2.37994527
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.36394478
97rRNA modification (GO:0000154)2.34312502
98regulation of memory T cell differentiation (GO:0043380)2.34296332
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.32762004
100regulation of activation of Janus kinase activity (GO:0010533)12.1221951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39182444
2EZH2_22144423_ChIP-Seq_EOC_Human3.49921441
3E2F7_22180533_ChIP-Seq_HELA_Human3.34477122
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.08454593
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.82143314
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.60134211
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52902209
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50463385
9VDR_22108803_ChIP-Seq_LS180_Human2.40786227
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16485678
11EWS_26573619_Chip-Seq_HEK293_Human2.14749522
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.13139763
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.11345752
14IGF1R_20145208_ChIP-Seq_DFB_Human2.09757361
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07349600
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05353419
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02661658
18FUS_26573619_Chip-Seq_HEK293_Human1.99418242
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88624374
20TAF15_26573619_Chip-Seq_HEK293_Human1.86959525
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82731063
22ELK1_19687146_ChIP-ChIP_HELA_Human1.77563773
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.72801278
24ZNF274_21170338_ChIP-Seq_K562_Hela1.71490338
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.70770550
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66797666
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64462389
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61514736
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59494949
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58926777
31MYC_18940864_ChIP-ChIP_HL60_Human1.56530704
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55714910
33BCAT_22108803_ChIP-Seq_LS180_Human1.55656787
34RNF2_27304074_Chip-Seq_NSC_Mouse1.53485349
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52695698
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.49619565
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.45449551
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44658876
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43773867
40P300_19829295_ChIP-Seq_ESCs_Human1.42992769
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.42842529
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42842529
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.42062461
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41960667
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41200597
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40259113
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38349422
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38031151
49ERG_20517297_ChIP-Seq_VCAP_Human1.37183689
50VDR_23849224_ChIP-Seq_CD4+_Human1.32381121
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.32098054
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29193461
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28032711
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25749062
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25704237
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25096010
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24858631
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24765915
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18234104
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.17812796
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17503374
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.16512945
63FOXP3_21729870_ChIP-Seq_TREG_Human1.16079609
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15187238
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13488116
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13448823
67AR_25329375_ChIP-Seq_VCAP_Human1.13365487
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13240708
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12447578
70TP53_22573176_ChIP-Seq_HFKS_Human1.11631032
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11614673
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11533008
73RUNX_20019798_ChIP-Seq_JUKART_Human1.10410972
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.09375899
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.08714810
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.08509131
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.07817981
78AR_20517297_ChIP-Seq_VCAP_Human1.07642162
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05737385
80IRF1_19129219_ChIP-ChIP_H3396_Human1.05413171
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04950490
82ER_23166858_ChIP-Seq_MCF-7_Human1.04550758
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.02676480
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.02005225
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.99038290
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96849382
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96797978
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96455056
89GATA3_21878914_ChIP-Seq_MCF-7_Human0.96268844
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.95586588
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.95367968
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94589590
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94014473
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92752841
95P53_22387025_ChIP-Seq_ESCs_Mouse0.92453258
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.92414173
97ERA_21632823_ChIP-Seq_H3396_Human0.92190066
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91540972
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91152300
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90535135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.10533693
2MP0004147_increased_porphyrin_level3.56054542
3MP0009840_abnormal_foam_cell3.43193940
4MP0006292_abnormal_olfactory_placode3.32520689
5MP0002234_abnormal_pharynx_morphology3.28341841
6MP0003880_abnormal_central_pattern3.22436690
7MP0005394_taste/olfaction_phenotype3.20851443
8MP0005499_abnormal_olfactory_system3.20851443
9MP0008789_abnormal_olfactory_epithelium3.15769994
10MP0003011_delayed_dark_adaptation2.67640127
11MP0001293_anophthalmia2.53066854
12MP0003890_abnormal_embryonic-extraembry2.39180030
13MP0001529_abnormal_vocalization2.37864989
14MP0000049_abnormal_middle_ear2.28092722
15MP0002102_abnormal_ear_morphology2.08356866
16MP0001905_abnormal_dopamine_level2.00740692
17MP0004885_abnormal_endolymph1.96059584
18MP0010030_abnormal_orbit_morphology1.94929524
19MP0002249_abnormal_larynx_morphology1.94211842
20MP0005423_abnormal_somatic_nervous1.89004579
21MP0008875_abnormal_xenobiotic_pharmacok1.81500840
22MP0004142_abnormal_muscle_tone1.78608555
23MP0009250_abnormal_appendicular_skeleto1.74819437
24MP0006276_abnormal_autonomic_nervous1.68876763
25MP0002653_abnormal_ependyma_morphology1.68276518
26MP0003724_increased_susceptibility_to1.62268800
27MP0003191_abnormal_cellular_cholesterol1.60075346
28MP0004133_heterotaxia1.57120878
29MP0001485_abnormal_pinna_reflex1.53490020
30MP0002282_abnormal_trachea_morphology1.50198608
31MP0003195_calcinosis1.47067494
32MP0002277_abnormal_respiratory_mucosa1.46302261
33MP0005377_hearing/vestibular/ear_phenot1.39584170
34MP0003878_abnormal_ear_physiology1.39584170
35MP0003937_abnormal_limbs/digits/tail_de1.34834523
36MP0002095_abnormal_skin_pigmentation1.31288881
37MP0002928_abnormal_bile_duct1.28683943
38MP0000538_abnormal_urinary_bladder1.27638152
39MP0009053_abnormal_anal_canal1.23546958
40MP0002148_abnormal_hypersensitivity_rea1.22167976
41MP0008961_abnormal_basal_metabolism1.21804908
42MP0002139_abnormal_hepatobiliary_system1.20038649
43MP0004782_abnormal_surfactant_physiolog1.19982046
44MP0000778_abnormal_nervous_system1.19585135
45MP0002233_abnormal_nose_morphology1.18500777
46MP0008995_early_reproductive_senescence1.15666803
47MP0003787_abnormal_imprinting1.10536357
48MP0005671_abnormal_response_to1.10184485
49MP0002405_respiratory_system_inflammati1.09679049
50MP0002160_abnormal_reproductive_system1.01774222
51MP0004043_abnormal_pH_regulation0.99689399
52MP0000631_abnormal_neuroendocrine_gland0.98870592
53MP0005187_abnormal_penis_morphology0.96654623
54MP0001984_abnormal_olfaction0.95771650
55MP0005391_vision/eye_phenotype0.95348418
56MP0000647_abnormal_sebaceous_gland0.92907365
57MP0002092_abnormal_eye_morphology0.91682269
58MP0009785_altered_susceptibility_to0.91228338
59MP0000026_abnormal_inner_ear0.90570412
60MP0003119_abnormal_digestive_system0.89679326
61MP0003828_pulmonary_edema0.89628177
62MP0005253_abnormal_eye_physiology0.88421331
63MP0002723_abnormal_immune_serum0.85168983
64MP0001963_abnormal_hearing_physiology0.84286106
65MP0000163_abnormal_cartilage_morphology0.84199695
66MP0003938_abnormal_ear_development0.84005354
67MP0002638_abnormal_pupillary_reflex0.83578287
68MP0002177_abnormal_outer_ear0.82511649
69MP0005410_abnormal_fertilization0.82493637
70MP0001286_abnormal_eye_development0.81428848
71MP0002933_joint_inflammation0.80176459
72MP0003436_decreased_susceptibility_to0.79680454
73MP0009764_decreased_sensitivity_to0.78239451
74MP0005551_abnormal_eye_electrophysiolog0.77176996
75MP0001800_abnormal_humoral_immune0.74301716
76MP0001188_hyperpigmentation0.73453528
77MP0002067_abnormal_sensory_capabilities0.72840152
78MP0000566_synostosis0.72552727
79MP0009379_abnormal_foot_pigmentation0.72322659
80MP0005389_reproductive_system_phenotype0.71902859
81MP0002752_abnormal_somatic_nervous0.70677745
82MP0002272_abnormal_nervous_system0.70618145
83MP0002938_white_spotting0.69094754
84MP0002116_abnormal_craniofacial_bone0.68669908
85MP0009697_abnormal_copulation0.68523270
86MP0008932_abnormal_embryonic_tissue0.66235717
87MP0003121_genomic_imprinting0.64092012
88MP0008872_abnormal_physiological_respon0.63917255
89MP0000230_abnormal_systemic_arterial0.62182855
90MP0001177_atelectasis0.62142833
91MP0002109_abnormal_limb_morphology0.61876945
92MP0004130_abnormal_muscle_cell0.61560107
93MP0005195_abnormal_posterior_eye0.61281692
94MP0002452_abnormal_antigen_presenting0.61070422
95MP0006072_abnormal_retinal_apoptosis0.60142678
96MP0002184_abnormal_innervation0.59697845
97MP0002697_abnormal_eye_size0.58992891
98MP0003385_abnormal_body_wall0.58756370
99MP0003122_maternal_imprinting0.58259243
100MP0000569_abnormal_digit_pigmentation0.57431730

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)4.08960793
2Increased hepatocellular lipid droplets (HP:0006565)3.94379494
3Type II lissencephaly (HP:0007260)3.90073924
4Abnormality of B cell number (HP:0010975)3.88625557
5Lipid accumulation in hepatocytes (HP:0006561)3.74040302
6Growth hormone deficiency (HP:0000824)3.57752373
7Retinal dysplasia (HP:0007973)3.57468117
8Pancreatic fibrosis (HP:0100732)3.28366674
9Cerebellar dysplasia (HP:0007033)3.28127603
103-Methylglutaconic aciduria (HP:0003535)3.26240726
11Pancreatic cysts (HP:0001737)3.22712278
12Abnormality of the phalanges of the 2nd finger (HP:0009541)3.21587019
13Renal cortical cysts (HP:0000803)3.20824134
14Severe short stature (HP:0003510)3.07824186
15Limb dystonia (HP:0002451)2.94281524
16Renal Fanconi syndrome (HP:0001994)2.92126446
17Abnormality of the renal cortex (HP:0011035)2.91853330
18Glycosuria (HP:0003076)2.76746441
19Abnormality of urine glucose concentration (HP:0011016)2.76746441
20Potter facies (HP:0002009)2.71899667
21Facial shape deformation (HP:0011334)2.71899667
22Congenital, generalized hypertrichosis (HP:0004540)2.71742910
23Abolished electroretinogram (ERG) (HP:0000550)2.71668836
24True hermaphroditism (HP:0010459)2.68332468
25Enlarged kidneys (HP:0000105)2.66715522
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65614106
27Abnormal number of erythroid precursors (HP:0012131)2.62310390
28Bile duct proliferation (HP:0001408)2.61787653
29Abnormal biliary tract physiology (HP:0012439)2.61787653
30IgM deficiency (HP:0002850)2.52486575
31Increased intramyocellular lipid droplets (HP:0012240)2.51714633
32Exertional dyspnea (HP:0002875)2.44235537
33Pancytopenia (HP:0001876)2.41200912
34Abnormal protein N-linked glycosylation (HP:0012347)2.39829630
35Abnormal protein glycosylation (HP:0012346)2.39829630
36Abnormal glycosylation (HP:0012345)2.39829630
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39829630
38Male pseudohermaphroditism (HP:0000037)2.36511024
39Lissencephaly (HP:0001339)2.36082875
40Adactyly (HP:0009776)2.35218860
41Disproportionate short-trunk short stature (HP:0003521)2.34283902
42Severe combined immunodeficiency (HP:0004430)2.33541963
43Mitochondrial inheritance (HP:0001427)2.30720340
44Nephronophthisis (HP:0000090)2.28106799
45Abnormality of the renal medulla (HP:0100957)2.28023514
46Duplicated collecting system (HP:0000081)2.23914262
47Chronic hepatic failure (HP:0100626)2.23609945
48Abnormality of cells of the erythroid lineage (HP:0012130)2.22673045
49Supernumerary spleens (HP:0009799)2.22664323
50Acute necrotizing encephalopathy (HP:0006965)2.21286393
51IgG deficiency (HP:0004315)2.20946493
52Recurrent bronchitis (HP:0002837)2.19956477
53Increased density of long bones (HP:0006392)2.16036509
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13095745
55Increased CSF lactate (HP:0002490)2.12333262
56Attenuation of retinal blood vessels (HP:0007843)2.11676388
57Abnormality of the renal collecting system (HP:0004742)2.11381168
58Hyperphosphaturia (HP:0003109)2.08107784
59Increased muscle lipid content (HP:0009058)2.07467544
60Molar tooth sign on MRI (HP:0002419)2.07339166
61Abnormality of midbrain morphology (HP:0002418)2.07339166
62Polymicrogyria (HP:0002126)2.06725281
63Abnormality of the phalanges of the 5th finger (HP:0004213)2.06593177
64Type I transferrin isoform profile (HP:0003642)2.01130302
65Generalized aminoaciduria (HP:0002909)2.00186406
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96530609
67Degeneration of the lateral corticospinal tracts (HP:0002314)1.96530609
68Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94414180
69Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93425487
70Premature ovarian failure (HP:0008209)1.93254798
71Acute encephalopathy (HP:0006846)1.93011077
72T lymphocytopenia (HP:0005403)1.92713597
73Anencephaly (HP:0002323)1.92579617
74Abnormal mitochondria in muscle tissue (HP:0008316)1.92527251
75Abnormality of the middle phalanges of the toes (HP:0010183)1.91790899
76Macrocytic anemia (HP:0001972)1.91405115
77Abnormality of renal resorption (HP:0011038)1.90999193
78Progressive macrocephaly (HP:0004481)1.88794898
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88238226
80Bell-shaped thorax (HP:0001591)1.87996874
81Genetic anticipation (HP:0003743)1.86886706
82Thyroiditis (HP:0100646)1.86168250
83Respiratory difficulties (HP:0002880)1.85895288
84Agitation (HP:0000713)1.83659994
85Large for gestational age (HP:0001520)1.83151117
86Type 2 muscle fiber atrophy (HP:0003554)1.82590507
87Depressed nasal ridge (HP:0000457)1.81151414
88Constricted visual fields (HP:0001133)1.80918628
89Pallor (HP:0000980)1.80843064
90Long nose (HP:0003189)1.80249191
91Congenital hepatic fibrosis (HP:0002612)1.78543133
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77745183
93Abnormality of the 2nd finger (HP:0004100)1.77533615
94Oligohydramnios (HP:0001562)1.77325800
95Hyperglycinemia (HP:0002154)1.75876315
96Persistence of primary teeth (HP:0006335)1.74564327
97Abnormality of DNA repair (HP:0003254)1.74508547
98Abnormal respiratory motile cilium morphology (HP:0005938)1.74105611
99Abnormal respiratory epithelium morphology (HP:0012253)1.74105611
100Sclerocornea (HP:0000647)1.73775464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.01542624
2ACVR1B3.78167509
3BCKDK3.73610202
4BLK3.68877596
5CDC72.38779474
6BMPR1B2.34003725
7GRK62.27569346
8MAP4K12.09089053
9TLK11.95570974
10TAOK31.78886151
11ZAK1.77543377
12TXK1.74230148
13MAP3K121.73183871
14TESK11.57813382
15FES1.54405023
16FLT31.52513030
17PASK1.47509873
18PLK41.40029157
19MAP3K111.37119931
20ADRBK11.37107292
21TEC1.35929988
22ITK1.33128588
23PIM11.33028273
24KDR1.30547695
25CDK191.29430023
26MATK1.28047743
27MAP2K21.26785978
28CDK81.26548972
29KIT1.21224341
30INSRR1.18111289
31ADRBK21.15346052
32CSK1.11131908
33TGFBR11.06260432
34GRK71.05748245
35PLK21.04838737
36PAK31.02734331
37WNK41.02524404
38FRK1.00165018
39SYK0.99955533
40MAPK130.99939896
41EIF2AK10.99593218
42CSF1R0.97750707
43EPHB20.97539552
44PIM20.96825501
45STK110.95249640
46ARAF0.92214188
47WNK30.89375523
48DYRK20.87256110
49EPHA40.81927025
50NME10.75343741
51SRPK10.71843643
52PINK10.71600137
53LYN0.71598271
54CSNK1G10.70992403
55ERBB30.69845463
56AKT30.69708257
57OXSR10.68860169
58JAK30.67708876
59PIK3CA0.66298522
60ERBB20.65191839
61PTK2B0.61624355
62LIMK10.60826834
63STK40.60736600
64TRIM280.60668196
65LCK0.59548969
66PNCK0.59402489
67TAOK10.59282414
68MAP3K130.59107945
69MAP3K10.57951768
70CAMK1G0.57665041
71VRK10.57074776
72CSNK1G20.56894244
73ZAP700.54855716
74FER0.54801809
75LRRK20.53770219
76TNIK0.52285469
77MAPK150.50909341
78PRKACB0.50829928
79PKN10.50718843
80MAP4K20.50673132
81STK100.50445285
82HIPK20.50169769
83MAP2K10.49088940
84RAF10.48011521
85INSR0.47154276
86FYN0.45593714
87PIK3CG0.42562249
88PRKCE0.42106744
89CAMK1D0.41419244
90TIE10.41199613
91CSNK1A10.40846105
92RPS6KA50.39670222
93CSNK2A20.39435911
94BTK0.38537215
95PRKCQ0.36220350
96CSNK2A10.35118124
97SGK4940.34730471
98SGK2230.34730471
99EIF2AK20.32160158
100CAMKK20.31615105

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.66254678
2Oxidative phosphorylation_Homo sapiens_hsa001903.62593893
3Caffeine metabolism_Homo sapiens_hsa002323.59718680
4Protein export_Homo sapiens_hsa030603.26003557
5Parkinsons disease_Homo sapiens_hsa050122.91630519
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81194084
7Proteasome_Homo sapiens_hsa030502.72039863
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70025175
9DNA replication_Homo sapiens_hsa030302.53152178
10Ribosome_Homo sapiens_hsa030102.51101892
11Homologous recombination_Homo sapiens_hsa034402.33956644
12Mismatch repair_Homo sapiens_hsa034302.22745702
13Tryptophan metabolism_Homo sapiens_hsa003802.16278824
14Alzheimers disease_Homo sapiens_hsa050102.04420277
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.04061976
16Fanconi anemia pathway_Homo sapiens_hsa034602.02547207
17Cardiac muscle contraction_Homo sapiens_hsa042601.89952431
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80568544
19Butanoate metabolism_Homo sapiens_hsa006501.74891306
20Primary immunodeficiency_Homo sapiens_hsa053401.72297103
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68735510
22Huntingtons disease_Homo sapiens_hsa050161.61161163
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50404903
24Peroxisome_Homo sapiens_hsa041461.43725311
25Nucleotide excision repair_Homo sapiens_hsa034201.33203769
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.29742556
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.27034229
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20670087
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20363400
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18980432
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18076315
32Regulation of autophagy_Homo sapiens_hsa041401.12303022
33One carbon pool by folate_Homo sapiens_hsa006701.11811739
34Hematopoietic cell lineage_Homo sapiens_hsa046400.97034509
35Steroid biosynthesis_Homo sapiens_hsa001000.95813559
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.94596446
37Phenylalanine metabolism_Homo sapiens_hsa003600.94149452
38Folate biosynthesis_Homo sapiens_hsa007900.94074815
39Nicotine addiction_Homo sapiens_hsa050330.89505269
40Basal transcription factors_Homo sapiens_hsa030220.88521092
41RNA polymerase_Homo sapiens_hsa030200.88350832
42Phototransduction_Homo sapiens_hsa047440.87865408
43RNA degradation_Homo sapiens_hsa030180.86341752
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82892041
45Antigen processing and presentation_Homo sapiens_hsa046120.82211143
46Morphine addiction_Homo sapiens_hsa050320.80057978
47Propanoate metabolism_Homo sapiens_hsa006400.76692710
48Spliceosome_Homo sapiens_hsa030400.75939424
49Purine metabolism_Homo sapiens_hsa002300.75862158
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70073502
51ABC transporters_Homo sapiens_hsa020100.70021852
52Tyrosine metabolism_Homo sapiens_hsa003500.68894357
53Taste transduction_Homo sapiens_hsa047420.67968134
54Fatty acid elongation_Homo sapiens_hsa000620.65556332
55GABAergic synapse_Homo sapiens_hsa047270.65323192
56Rheumatoid arthritis_Homo sapiens_hsa053230.63456222
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63380546
58Arachidonic acid metabolism_Homo sapiens_hsa005900.58433589
59Collecting duct acid secretion_Homo sapiens_hsa049660.57990932
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.57756339
61N-Glycan biosynthesis_Homo sapiens_hsa005100.57498677
62Fatty acid degradation_Homo sapiens_hsa000710.56302966
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.51650127
64Chemical carcinogenesis_Homo sapiens_hsa052040.50206409
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50113168
66Systemic lupus erythematosus_Homo sapiens_hsa053220.49317522
67Glutathione metabolism_Homo sapiens_hsa004800.48979797
68Hedgehog signaling pathway_Homo sapiens_hsa043400.48287359
69Base excision repair_Homo sapiens_hsa034100.47093556
70Pyrimidine metabolism_Homo sapiens_hsa002400.46156629
71Metabolic pathways_Homo sapiens_hsa011000.45965429
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45840152
73Legionellosis_Homo sapiens_hsa051340.45528179
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45199831
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.42095089
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41466298
77Olfactory transduction_Homo sapiens_hsa047400.41327582
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.40137953
79Type I diabetes mellitus_Homo sapiens_hsa049400.39945471
80Fatty acid metabolism_Homo sapiens_hsa012120.39035048
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38003147
82TGF-beta signaling pathway_Homo sapiens_hsa043500.35708873
83Retinol metabolism_Homo sapiens_hsa008300.35132068
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33743308
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.33097533
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30943837
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30070075
88Epstein-Barr virus infection_Homo sapiens_hsa051690.28911522
89Shigellosis_Homo sapiens_hsa051310.26675564
90Asthma_Homo sapiens_hsa053100.26436474
91Circadian entrainment_Homo sapiens_hsa047130.25900397
92Graft-versus-host disease_Homo sapiens_hsa053320.24518180
93Osteoclast differentiation_Homo sapiens_hsa043800.23194803
94Circadian rhythm_Homo sapiens_hsa047100.22497854
95Linoleic acid metabolism_Homo sapiens_hsa005910.22070510
96MAPK signaling pathway_Homo sapiens_hsa040100.21269662
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20786168
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20270546
99Allograft rejection_Homo sapiens_hsa053300.19852325
100Autoimmune thyroid disease_Homo sapiens_hsa053200.18892899

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